id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
274,810,357
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc(Cl)c1Cl
COc1ccc(N)cc1Cl.Cl
Cc1cc(N)cnc1Br
COc1ccc(Nc2nc(Nc3cnc(Br)c(C)c3)nc(N[C@@H](CC(=O)N[Dy])c3cccc(Cl)c3Cl)n2)cc1Cl
HSA
0
241,384,961
O=C(O)COC[C@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCCNC(=O)c1ccno1
COc1ccncc1CN
COc1ccncc1CNc1nc(NCCNC(=O)c2ccno2)nc(N2CCC[C@@H]2COCC(=O)N[Dy])n1
sEH
0
88,800,834
O=C(N[C@@H](CC1CC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CC(C(N)=O)=NO1
Nc1nc(-c2ccccc2Cl)cs1
NC(=O)C1=NOC(CNc2nc(Nc3nc(-c4ccccc4Cl)cs3)nc(N[C@@H](CC3CC3)C(=O)N[Dy])n2)C1
BRD4
0
201,716,869
O=C(Nc1ccc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CNC(=O)C(O)CN.Cl
C=CCOCCN
C=CCOCCNc1nc(NCC(O)C(=O)NC)nc(Nc2ccc(F)cc2C(=O)N[Dy])n1
HSA
0
223,274,297
O=C(Nc1nc(-c2ccc(C(=O)O)cc2)cs1)OCC1c2ccccc2-c2ccccc21
Nc1cnc(Cl)nc1
Cl.NCCS(=O)(=O)C1CCOCC1
O=C(N[Dy])c1ccc(-c2csc(Nc3nc(NCCS(=O)(=O)C4CCOCC4)nc(Nc4cnc(Cl)nc4)n3)n2)cc1
sEH
0
158,030,288
O=C(Nc1cc(Br)c(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CC(CN)S(N)(=O)=O.Cl
Cc1ccncc1N
Cc1ccncc1Nc1nc(NCC(C)S(N)(=O)=O)nc(Nc2cc(Br)c(F)cc2C(=O)N[Dy])n1
sEH
0
36,595,785
COc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
Cl.NCc1ccc(-c2c[nH]c(=O)[nH]c2=O)cc1
COC(=O)c1occc1N
COC(=O)c1occc1Nc1nc(NCc2ccc(-c3c[nH]c(=O)[nH]c3=O)cc2)nc(Nc2ccc(OC)cc2C(=O)N[Dy])n1
BRD4
0
180,714,701
O=C(Nc1ccc(Br)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)C(O)CCC2
CC12CCC(CN)(C1)OC2.Cl
CC12CCC(CNc3nc(Nc4ccc(Br)c(C(=O)N[Dy])c4)nc(Nc4ccc5c(c4)C(O)CCC5)n3)(C1)OC2
sEH
0
212,570,591
O=C(Nc1cccc(F)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCON(C)C(=O)CN.Cl
COc1ncc(N)cc1C(F)(F)F
CCON(C)C(=O)CNc1nc(Nc2cnc(OC)c(C(F)(F)F)c2)nc(Nc2cccc(F)c2C(=O)N[Dy])n1
sEH
0
134,240,009
O=C(Nc1c(Br)cc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cc(C#N)c(F)cc1N
NCCc1ccc(N2CCOCC2)c(F)c1
COc1cc(C#N)c(F)cc1Nc1nc(NCCc2ccc(N3CCOCC3)c(F)c2)nc(Nc2c(Br)cc(F)cc2C(=O)N[Dy])n1
sEH
0
255,874,438
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
Nc1ccc([N+](=O)[O-])c(Br)c1
CCOC(=O)c1sc(N)nc1C
CCOC(=O)c1sc(Nc2nc(Nc3ccc([N+](=O)[O-])c(Br)c3)nc(N[C@H](CC(=O)N[Dy])c3ccc(Br)cc3)n2)nc1C
HSA
0
167,351,678
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cscc1C(F)(F)F
Nc1nccc(-c2cccnc2)n1
O=C(N[Dy])c1ccc(Cl)c(Nc2nc(NCc3cscc3C(F)(F)F)nc(Nc3nccc(-c4cccnc4)n3)n2)c1
sEH
0
190,185,304
O=C(Nc1ccc(C(=O)O)cc1Cl)OCC1c2ccccc2-c2ccccc21
Cl.NCCNC(=O)c1ccno1
COC(=O)c1c[nH]nc1N
COC(=O)c1c[nH]nc1Nc1nc(NCCNC(=O)c2ccno2)nc(Nc2ccc(C(=O)N[Dy])cc2Cl)n1
HSA
0
217,291,099
O=C(Nc1cccnc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCCn1cc(C2CC2)nn1
Nc1cc(CO)ccn1
O=C(N[Dy])c1ncccc1Nc1nc(NCCn2cc(C3CC3)nn2)nc(Nc2cc(CO)ccn2)n1
HSA
0
250,660,248
O=C(O)C[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
CC1CCCC(CN)O1
Cl.Cn1cc(CN)c(=O)[nH]c1=O
CC1CCCC(CNc2nc(NCc3cn(C)c(=O)[nH]c3=O)nc(N[C@@H](CC(=O)N[Dy])Cc3ccc([N+](=O)[O-])cc3)n2)O1
BRD4
0
141,820,974
O=C(Nc1c(C(=O)O)cnn1CCO)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cncc(N)c1
Cl.NCc1nc2ccccc2c(=O)[nH]1
COC(=O)c1cncc(Nc2nc(NCc3nc4ccccc4c(=O)[nH]3)nc(Nc3c(C(=O)N[Dy])cnn3CCO)n2)c1
BRD4
0
33,462,518
COc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)cc1OC
NCCN1CC[C@@H](O)C1
COC(=O)c1cc(N)cc(F)c1
COC(=O)c1cc(F)cc(Nc2nc(NCCN3CC[C@@H](O)C3)nc(Nc3cc(OC)c(OC)cc3C(=O)N[Dy])n2)c1
sEH
0
259,504,797
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc([N+](=O)[O-])c1
COC1(C(F)(F)CN)CCOCC1.Cl
NCc1cn(C(F)F)c2ccccc12
COC1(C(F)(F)CNc2nc(NCc3cn(C(F)F)c4ccccc34)nc(N[C@H](CC(=O)N[Dy])c3cccc([N+](=O)[O-])c3)n2)CCOCC1
BRD4
0
149,231,907
O=C(Nc1c(F)cc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1nccc2cccnc12
Cc1ccc(N)nn1
Cc1ccc(Nc2nc(Nc3c(F)cc(Br)cc3C(=O)N[Dy])nc(Nc3nccc4cccnc34)n2)nn1
BRD4
0
5,085,478
C#CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCC(O)COc1cccc(Cl)c1Cl
Cc1cc(CN)c(C)s1
C#CC[C@H](Nc1nc(NCc2cc(C)sc2C)nc(NCC(O)COc2cccc(Cl)c2Cl)n1)C(=O)N[Dy]
HSA
0
106,600,144
O=C(N[C@@H](Cc1cccs1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(N2CCOCC2)cc1
COc1cccc(F)c1CN
COc1cccc(F)c1CNc1nc(Nc2ccc(N3CCOCC3)cc2)nc(N[C@@H](Cc2cccs2)C(=O)N[Dy])n1
HSA
0
215,380,737
O=C(Nc1cccc([N+](=O)[O-])c1C(=O)O)OCC1c2ccccc2-c2ccccc21
NCC1CC2(CC2)CO1
Cn1nccc1N
Cn1nccc1Nc1nc(NCC2CC3(CC3)CO2)nc(Nc2cccc([N+](=O)[O-])c2C(=O)N[Dy])n1
BRD4
0
175,270,951
O=C(Nc1cc(F)cc(F)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CCC2=O
Cl.NCC1(O)C2C3CC4C5C3CC2C5C41
O=C1CCc2cc(Nc3nc(NCC4(O)C5C6CC7C8C6CC5C8C74)nc(Nc4cc(F)cc(F)c4C(=O)N[Dy])n3)ccc21
HSA
0
277,413,257
O=C(O)C[C@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cn1ccc2cc(N)ccc21
Nc1ccc(N2CCOCC2)cn1
Cn1ccc2cc(Nc3nc(Nc4ccc(N5CCOCC5)cn4)nc(N4Cc5ccccc5C[C@@H]4CC(=O)N[Dy])n3)ccc21
sEH
0
190,834,493
O=C(Nc1ccc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(N)cc(O)c1
CC(C)(C)c1ccc(O)c(N)c1
COC(=O)c1cc(O)cc(Nc2nc(Nc3cc(C(C)(C)C)ccc3O)nc(Nc3ccc(C(=O)N[Dy])cc3F)n2)c1
sEH
0
293,477,379
O=C(O)[C@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cc1ccccc1-c1csc(N)n1
Cl.NCC1CCCC2(CCC2)C1O
Cc1ccccc1-c1csc(Nc2nc(NCC3CCCC4(CCC4)C3O)nc(N3Cc4ccccc4C[C@@H]3C(=O)N[Dy])n2)n1
BRD4
0
183,681,588
O=C(Nc1ccc(C(=O)O)c(C(F)(F)F)c1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1ccc[nH]c1=O
N#Cc1ccc2nc(N)sc2c1
N#Cc1ccc2nc(Nc3nc(NCc4ccc[nH]c4=O)nc(Nc4ccc(C(=O)N[Dy])c(C(F)(F)F)c4)n3)sc2c1
BRD4
0
226,678,058
O=C(Nc1nc2ccc(C(=O)O)cc2s1)OCC1c2ccccc2-c2ccccc21
CC1(C)CC(CCN)C(=O)N1.Cl
Cl.NCC1CC2(C1)CC2(F)F
CC1(C)CC(CCNc2nc(NCC3CC4(C3)CC4(F)F)nc(Nc3nc4ccc(C(=O)N[Dy])cc4s3)n2)C(=O)N1
sEH
0
287,993,977
O=C(O)[C@H]1CC2CCCCC2N1C(=O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)n(C(C)C)n1
NCCc1ccc(N2CCOCC2)c(F)c1
Cc1cc(Nc2nc(NCCc3ccc(N4CCOCC4)c(F)c3)nc(N3C4CCCCC4C[C@@H]3C(=O)N[Dy])n2)n(C(C)C)n1
HSA
0
44,160,816
C[C@@H](OCc1ccccc1)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.NCC=C(Cl)Cl
Cl.NCc1nc2cc(F)ccc2o1
C[C@@H](OCc1ccccc1)[C@H](Nc1nc(NCC=C(Cl)Cl)nc(NCc2nc3cc(F)ccc3o2)n1)C(=O)N[Dy]
BRD4
0
285,805,215
O=C(O)[C@@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)ccc1Cl
Nc1cccc(OC(F)F)c1
Cc1cc(Nc2nc(Nc3cccc(OC(F)F)c3)nc(N3Cc4ccccc4C[C@H]3C(=O)N[Dy])n2)ccc1Cl
BRD4
0
95,520,403
O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCC1(O)CCCC1
NC/C=C/Br
O=C(N[Dy])[C@H](Cc1ccc(Cl)c(Cl)c1)Nc1nc(NC/C=C/Br)nc(NCC2(O)CCCC2)n1
HSA
0
231,463,614
O=C(Nc1ncc(C(=O)O)s1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
COc1ccc(N)nc1
COc1ccc(Nc2nc(NCc3ccc(O)c4ncccc34)nc(Nc3ncc(C(=O)N[Dy])s3)n2)nc1
BRD4
0
99,215,731
O=C(N[C@@H](Cc1ccc(F)cc1F)C(=O)O)OCC1c2ccccc2-c2ccccc21
CC1(F)CCN(CCN)C1.Cl.Cl
Cc1sc(CN)nc1C(C)C
Cc1sc(CNc2nc(NCCN3CCC(C)(F)C3)nc(N[C@@H](Cc3ccc(F)cc3F)C(=O)N[Dy])n2)nc1C(C)C
HSA
0
234,275,634
O=C(O)C1CN(C(=O)OCC2c3ccccc3-c3ccccc32)C1
CC(C)(CN)C(=O)N1CCCC1
COC(=O)Cc1nc(N)sc1C
COC(=O)Cc1nc(Nc2nc(NCC(C)(C)C(=O)N3CCCC3)nc(N3CC(C(=O)N[Dy])C3)n2)sc1C
BRD4
0
138,654,398
O=C(Nc1c(C(=O)O)ccc2ccccc12)OCC1c2ccccc2-c2ccccc21
COc1cncc(N)n1
Cl.NC[C@@H]1C[C@@H]2O[C@H]1[C@H]1C[C@H]12
COc1cncc(Nc2nc(NC[C@@H]3C[C@@H]4O[C@H]3[C@H]3C[C@H]34)nc(Nc3c(C(=O)N[Dy])ccc4ccccc34)n2)n1
sEH
0
12,778,319
CC(C)(C)OC(=O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCc1c(Br)cncc1Br
Nc1n[nH]c2c(Cl)cc([N+](=O)[O-])cc12
CC(C)(C)OC(=O)CC(Nc1nc(NCc2c(Br)cncc2Br)nc(Nc2n[nH]c3c(Cl)cc([N+](=O)[O-])cc23)n1)C(=O)N[Dy]
sEH
0
23,207,300
CCS(=O)(=O)c1cc(C(=O)O)c(OC)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1c(Br)cncc1CN.Cl.Cl
Cl.NCc1nc2ccccc2o1
CCS(=O)(=O)c1cc(C(=O)N[Dy])c(OC)cc1Nc1nc(NCc2nc3ccccc3o2)nc(NCc2cncc(Br)c2C)n1
sEH
0
100,442,328
O=C(N[C@@H](Cc1ccc(I)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COC1(CN)CCC1
Cl.NCCNC(=O)c1ccccc1F
COC1(CNc2nc(NCCNC(=O)c3ccccc3F)nc(N[C@@H](Cc3ccc(I)cc3)C(=O)N[Dy])n2)CCC1
BRD4
0
130,825,614
O=C(N[C@H]1CC[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
CCC(CC)(CN)OC
Nc1ncccc1C=O
CCC(CC)(CNc1nc(Nc2ncccc2C=O)nc(N[C@H]2CC[C@@H](C(=O)N[Dy])C2)n1)OC
BRD4
0
85,309,924
O=C(N[C@@H](C(=O)O)C1CCCC1)OCC1c2ccccc2-c2ccccc21
Cc1c([C@@H]2[C@@H](CN)CC(=O)N2C)cnn1C
Cn1nccc1N
Cc1c([C@@H]2[C@@H](CNc3nc(Nc4ccnn4C)nc(N[C@@H](C(=O)N[Dy])C4CCCC4)n3)CC(=O)N2C)cnn1C
HSA
0
240,746,728
O=C(O)CNC(=O)OCC1c2ccccc2-c2ccccc21
Nc1nccc(Cl)n1
CN(Cc1ccco1)Cc1ccccc1CN
CN(Cc1ccco1)Cc1ccccc1CNc1nc(NCC(=O)N[Dy])nc(Nc2nccc(Cl)n2)n1
HSA
0
277,289,341
O=C(O)C[C@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CC2CC1C1CC21
CC(C)(CN)C(=O)N1CCCC1
CC(C)(CNc1nc(NCC2CC3CC2C2CC32)nc(N2Cc3ccccc3C[C@@H]2CC(=O)N[Dy])n1)C(=O)N1CCCC1
HSA
0
129,833,604
O=C(N[C@H]1CCC[C@@H]1C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cnc(N)cn1
CCC1=NN(Cc2ccccc2C)C(=O)C1CCN
CCC1=NN(Cc2ccccc2C)C(=O)C1CCNc1nc(Nc2cnc(C(=O)OC)cn2)nc(N[C@H]2CCC[C@@H]2C(=O)N[Dy])n1
BRD4
0
293,904,908
O=C(O)[C@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
NCc1cn(-c2ccccc2)nc1-c1ccncc1
Nc1ncnc2[nH]ncc12
O=C(N[Dy])[C@H]1Cc2ccccc2CN1c1nc(NCc2cn(-c3ccccc3)nc2-c2ccncc2)nc(Nc2ncnc3[nH]ncc23)n1
sEH
0
24,946,274
CCc1cccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c1C(=O)O
Nc1cccc(CN2CCCCC2)c1
Cc1cc(Cl)ncc1N
CCc1cccc(Nc2nc(Nc3cccc(CN4CCCCC4)c3)nc(Nc3cnc(Cl)cc3C)n2)c1C(=O)N[Dy]
sEH
0
221,209,825
O=C(Nc1cnccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CC(C)CC(C)(CN)NC(=O)c1cc(Cl)c(Cl)[nH]1.Cl
Cc1ccsc1CN
Cc1ccsc1CNc1nc(NCC(C)(CC(C)C)NC(=O)c2cc(Cl)c(Cl)[nH]2)nc(Nc2cnccc2C(=O)N[Dy])n1
HSA
0
221,203,739
O=C(Nc1cnccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CC(C)(C)c1ocnc1CN.Cl
Cl.Cl.NCCc1nnc2c(=O)[nH]ccn12
CC(C)(C)c1ocnc1CNc1nc(NCCc2nnc3c(=O)[nH]ccn23)nc(Nc2cnccc2C(=O)N[Dy])n1
sEH
0
112,117,563
O=C(N[C@H](C(=O)O)C1CC1)OCC1c2ccccc2-c2ccccc21
Nc1cccc2ocnc12
Cl.Cl.NCc1ccncc1C(F)(F)F
O=C(N[Dy])[C@@H](Nc1nc(NCc2ccncc2C(F)(F)F)nc(Nc2cccc3ocnc23)n1)C1CC1
BRD4
0
185,027,113
O=C(Nc1ccc(C(=O)O)c(Cl)c1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(F)c(C(F)(F)F)c1
Nc1nc(Cl)c2cn[nH]c2n1
O=C(N[Dy])c1ccc(Nc2nc(Nc3ccc(F)c(C(F)(F)F)c3)nc(Nc3nc(Cl)c4cn[nH]c4n3)n2)cc1Cl
HSA
0
234,482,265
O=C(O)C1CN(C(=O)OCC2c3ccccc3-c3ccccc32)C1
COc1cc(F)c(Cl)cc1N
Cc1cc(CN)cc(Cl)n1.Cl.Cl
COc1cc(F)c(Cl)cc1Nc1nc(NCc2cc(C)nc(Cl)c2)nc(N2CC(C(=O)N[Dy])C2)n1
BRD4
0
219,105,812
O=C(Nc1cnc(Cl)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCOCCCN
NCc1ccc2[nH]ccc2c1
CCOCCCNc1nc(NCc2ccc3[nH]ccc3c2)nc(Nc2cnc(Cl)cc2C(=O)N[Dy])n1
sEH
0
191,115,835
O=C(Nc1ccc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
Cl.Cl.Cn1ccnc1Cn1c(CCCN)nc2c1CCCC2
Cc1cccc(CCCN)n1
Cc1cccc(CCCNc2nc(NCCCc3nc4c(n3Cc3nccn3C)CCCC4)nc(Nc3ccc(C(=O)N[Dy])cc3F)n2)n1
HSA
0
80,299,119
O=C(NC1(C(=O)O)CCOCC1)OCC1c2ccccc2-c2ccccc21
NCCC1OCCc2ccccc21
NCC1CCCCC(F)(F)C1
O=C(N[Dy])C1(Nc2nc(NCCC3OCCc4ccccc43)nc(NCC3CCCCC(F)(F)C3)n2)CCOCC1
BRD4
0
291,641,583
O=C(O)[C@H]1COCCN1C(=O)OCC1c2ccccc2-c2ccccc21
NCC1CC2(CC2)CO1
Cl.Cl.NCC(O)c1ccncc1
O=C(N[Dy])[C@H]1COCCN1c1nc(NCC2CC3(CC3)CO2)nc(NCC(O)c2ccncc2)n1
BRD4
0
124,931,805
O=C(N[C@H](Cc1ccc(I)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCC1(N2CCOCC2)CC1
CCOC(=O)c1ncccc1N
CCOC(=O)c1ncccc1Nc1nc(NCC2(N3CCOCC3)CC2)nc(N[C@H](Cc2ccc(I)cc2)C(=O)N[Dy])n1
BRD4
0
191,325,367
O=C(Nc1ccc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
Cl.NCc1nc2cc(F)ccc2o1
NCc1ccc(CN2CCCC2=O)cc1
O=C(N[Dy])c1ccc(Nc2nc(NCc3ccc(CN4CCCC4=O)cc3)nc(NCc3nc4cc(F)ccc4o3)n2)c(F)c1
HSA
0
124,082,565
O=C(N[C@H](Cc1ccc(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccc(-n2cncn2)c1
Nc1ccc(N2CCOCC2)cc1
O=C(N[Dy])[C@@H](Cc1ccc(F)c(F)c1)Nc1nc(Nc2ccc(N3CCOCC3)cc2)nc(Nc2cccc(-n3cncn3)c2)n1
BRD4
0
22,220,437
CCOc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(Cl)cc1C(=O)O
Cc1nc(Cl)ccc1N
COc1nc(Br)ccc1N
CCOc1cc(Nc2nc(Nc3ccc(Cl)nc3C)nc(Nc3ccc(Br)nc3OC)n2)c(Cl)cc1C(=O)N[Dy]
HSA
0
106,851,050
O=C(N[C@@H](Cc1ccsc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CCC#CCN
Cl.Cl.NCC#Cc1cccnc1
CCC#CCNc1nc(NCC#Cc2cccnc2)nc(N[C@@H](Cc2ccsc2)C(=O)N[Dy])n1
sEH
0
72,861,742
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CCC2=O
Cn1nnc(N)n1
Cn1nnc(Nc2nc(Nc3ccc4c(c3)CCC4=O)nc(NC(CC3CCCCC3)C(=O)N[Dy])n2)n1
HSA
0
106,076,770
O=C(N[C@@H](Cc1cccs1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1cccc(OCCCN)c1C.Cl
Cc1cc(N)nn1C
Cc1cccc(OCCCNc2nc(Nc3cc(C)n(C)n3)nc(N[C@@H](Cc3cccs3)C(=O)N[Dy])n2)c1C
HSA
0
19,844,190
CCC(C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COc1c(N)cccc1F
CCSC1CCC1(O)CN
CCSC1CCC1(O)CNc1nc(Nc2cccc(F)c2OC)nc(NC(C(=O)N[Dy])C(C)CC)n1
BRD4
0
56,669,682
Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
C=CCSCCN
COC(=O)c1cscc1N.Cl
C=CCSCCNc1nc(Nc2cscc2C(=O)OC)nc(N[C@@H](Cc2ccc(C)cc2)C(=O)N[Dy])n1
BRD4
0
212,815,518
O=C(Nc1cccc(F)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)ccc1O
Cc1nc(N)ccc1[N+](=O)[O-]
Cc1cc(Nc2nc(Nc3ccc([N+](=O)[O-])c(C)n3)nc(Nc3cccc(F)c3C(=O)N[Dy])n2)ccc1O
BRD4
0
185,682,663
O=C(Nc1ccc(C(=O)O)c(F)c1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC=Cc1cccnc1
COC(=O)c1cc(OC)c(OC)cc1N
COC(=O)c1cc(OC)c(OC)cc1Nc1nc(NCC=Cc2cccnc2)nc(Nc2ccc(C(=O)N[Dy])c(F)c2)n1
BRD4
0
214,433,704
O=C(Nc1cccc(I)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cl)c(C(F)(F)F)c1
Cl.NCC1CC2(C1)CC2(F)F
O=C(N[Dy])c1c(I)cccc1Nc1nc(NCC2CC3(C2)CC3(F)F)nc(Nc2ccc(Cl)c(C(F)(F)F)c2)n1
HSA
0
264,400,184
O=C(O)C[C@H](Cc1c(F)c(F)c(F)c(F)c1F)NC(=O)OCC1c2ccccc2-c2ccccc21
NCC1CCC(C(F)F)CC1
CCC1=NN(Cc2ccccc2C)C(=O)C1CCN
CCC1=NN(Cc2ccccc2C)C(=O)C1CCNc1nc(NCC2CCC(C(F)F)CC2)nc(N[C@H](CC(=O)N[Dy])Cc2c(F)c(F)c(F)c(F)c2F)n1
sEH
0
21,323,677
CCCCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.NCCc1c[nH]c2cc(Cl)ccc12
Cl.NCC1CC(=O)N(Cc2ccccc2)C1
CCCCC(Nc1nc(NCCc2c[nH]c3cc(Cl)ccc23)nc(NCC2CC(=O)N(Cc3ccccc3)C2)n1)C(=O)N[Dy]
HSA
0
291,994,626
O=C(O)[C@H]1C[C@H](O)CN1C(=O)OCC1c2ccccc2-c2ccccc21
C=CCOCCCN
CN(C)c1cccnc1CN
C=CCOCCCNc1nc(NCc2ncccc2N(C)C)nc(N2C[C@@H](O)C[C@@H]2C(=O)N[Dy])n1
BRD4
0
62,925,499
Cn1cc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)c2ccccc21
NCc1cccnc1
Cl.NCCNC(=O)c1ccno1
Cn1cc(C[C@@H](Nc2nc(NCCNC(=O)c3ccno3)nc(NCc3cccnc3)n2)C(=O)N[Dy])c2ccccc21
HSA
0
67,253,401
N#Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
NCc1c(Br)cncc1Br
CCOC(=O)c1c(C)csc1N
CCOC(=O)c1c(C)csc1Nc1nc(NCc2c(Br)cncc2Br)nc(N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[Dy])n1
HSA
0
227,535,814
O=C(Nc1nc2ccc(C(=O)O)cc2s1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(N2CCOCC2)c(F)c1
N#Cc1cccc(N)n1
N#Cc1cccc(Nc2nc(Nc3ccc(N4CCOCC4)c(F)c3)nc(Nc3nc4ccc(C(=O)N[Dy])cc4s3)n2)n1
HSA
0
47,092,902
Cc1cc(Br)c(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
COc1cc(F)c(Cl)cc1N
NCc1nc(-c2ccsc2)no1
COc1cc(F)c(Cl)cc1Nc1nc(NCc2nc(-c3ccsc3)no2)nc(Nc2cc(C(=O)N[Dy])c(Br)cc2C)n1
BRD4
0
149,377,391
O=C(Nc1c(F)cc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
CCON(CC)C(=O)CN.Cl
Nc1cccc(OC(F)F)c1
CCON(CC)C(=O)CNc1nc(Nc2cccc(OC(F)F)c2)nc(Nc2c(F)cc(C(=O)N[Dy])cc2F)n1
sEH
0
261,696,143
O=C(O)C[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
COCc1ccc(N)cc1
Nc1ccnc(-c2ccccc2)c1
COCc1ccc(Nc2nc(Nc3ccnc(-c4ccccc4)c3)nc(N3CCC[C@H]3CC(=O)N[Dy])n2)cc1
sEH
0
48,425,483
Cc1cc(Br)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
Cl.Cl.NC[C@@H]1CCO[C@H]1c1cn[nH]c1
Nc1nc2ccccc2o1
Cc1cc(Br)c(Nc2nc(NC[C@@H]3CCO[C@H]3c3cn[nH]c3)nc(Nc3nc4ccccc4o3)n2)c(C(=O)N[Dy])c1
sEH
0
129,497,332
O=C(N[C@H]1C=C[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
Nc1ccc([N+](=O)[O-])cn1
Cl.NCC(=O)NC1CCC1
O=C(CNc1nc(Nc2ccc([N+](=O)[O-])cn2)nc(N[C@H]2C=C[C@@H](C(=O)N[Dy])C2)n1)NC1CCC1
HSA
0
193,459,566
O=C(Nc1ccc(C(=O)O)cc1OC(F)(F)F)OCC1c2ccccc2-c2ccccc21
Cl.NCCOCC(F)F
Nc1nc(Cl)c(C=O)c(Cl)n1
O=Cc1c(Cl)nc(Nc2nc(NCCOCC(F)F)nc(Nc3ccc(C(=O)N[Dy])cc3OC(F)(F)F)n2)nc1Cl
BRD4
0
275,077,181
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc(Cl)c1Cl
Cl.Cn1nnc(CN)c1C(F)F
C=C(C)COCCN.Cl
C=C(C)COCCNc1nc(NCc2nnn(C)c2C(F)F)nc(N[C@@H](CC(=O)N[Dy])c2cccc(Cl)c2Cl)n1
sEH
0
293,216,185
O=C(O)[C@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
CN1C(=O)Cc2cc(CN)ccc21.Cl
NCc1nccs1
CN1C(=O)Cc2cc(CNc3nc(NCc4nccs4)nc(N4Cc5ccccc5C[C@@H]4C(=O)N[Dy])n3)ccc21
HSA
0
41,277,465
COc1nccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2cn[nH]c2c1
Nc1ccc2c(c1)oc1ccccc12
COc1nccc(C(=O)N[Dy])c1Nc1nc(Nc2ccc3cn[nH]c3c2)nc(Nc2ccc3c(c2)oc2ccccc23)n1
BRD4
0
90,553,875
O=C(N[C@@H](Cc1c(F)c(F)c(F)c(F)c1F)C(=O)O)OCC1c2ccccc2-c2ccccc21
CCn1cc2cc(N)ccc2n1
Cc1cc(CN)cc(Cl)n1.Cl.Cl
CCn1cc2cc(Nc3nc(NCc4cc(C)nc(Cl)c4)nc(N[C@@H](Cc4c(F)c(F)c(F)c(F)c4F)C(=O)N[Dy])n3)ccc2n1
BRD4
0
8,357,444
C=CCC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCC1(CO)CC2C=CC1C2
CC1(C)CC(CCN)C(=O)N1.Cl
C=CCC[C@@H](Nc1nc(NCCC2CC(C)(C)NC2=O)nc(NCC2(CO)CC3C=CC2C3)n1)C(=O)N[Dy]
sEH
0
164,212,936
O=C(Nc1cc(C(=O)O)ccc1Br)OCC1c2ccccc2-c2ccccc21
NCc1c(Br)cncc1Br
Cc1cnc(F)c(CN)c1
Cc1cnc(F)c(CNc2nc(NCc3c(Br)cncc3Br)nc(Nc3cc(C(=O)N[Dy])ccc3Br)n2)c1
HSA
0
61,424,607
Cc1ccccc1[C@@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1ccnc(Cl)c1N
CC(C)c1nc(N)sc1Br
Cc1ccccc1[C@@H](CC(=O)N[Dy])Nc1nc(Nc2nc(C(C)C)c(Br)s2)nc(Nc2c(C)ccnc2Cl)n1
BRD4
0
290,133,586
O=C(O)[C@H]1CCN1C(=O)OCC1c2ccccc2-c2ccccc21
Cc1c(CN)oc2ccc(F)cc12.Cl
Cc1cnc(O)c(N)c1
Cc1cnc(O)c(Nc2nc(NCc3oc4ccc(F)cc4c3C)nc(N3CC[C@@H]3C(=O)N[Dy])n2)c1
HSA
0
161,929,787
O=C(Nc1cc(Br)cnc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cn1ccnc1N
Cl.NCc1ccc(-c2nnn[nH]2)cc1
Cn1ccnc1Nc1nc(NCc2ccc(-c3nnn[nH]3)cc2)nc(Nc2cc(Br)cnc2C(=O)N[Dy])n1
sEH
0
195,671,311
O=C(Nc1ccc(C(=O)O)nc1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc(Cl)s1
Nc1ncnc2[nH]cnc12
O=C(N[Dy])c1ccc(Nc2nc(NCc3cnc(Cl)s3)nc(Nc3ncnc4[nH]cnc34)n2)cn1
HSA
0
103,303,115
O=C(N[C@@H](Cc1ccccc1F)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cl)c(F)c1
NCC1(O)CC1
O=C(N[Dy])[C@H](Cc1ccccc1F)Nc1nc(NCC2(O)CC2)nc(Nc2ccc(Cl)c(F)c2)n1
sEH
0
167,497,258
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
NCc1cccc(C(F)(F)F)c1
C#CCOc1ccc(CN)cc1.Cl
C#CCOc1ccc(CNc2nc(NCc3cccc(C(F)(F)F)c3)nc(Nc3cc(C(=O)N[Dy])ccc3Cl)n2)cc1
HSA
0
96,736,576
O=C(N[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(F)c(F)cc1[N+](=O)[O-]
Cl.Cl.NCCNC(=O)c1cnccn1
O=C(NCCNc1nc(Nc2cc(F)c(F)cc2[N+](=O)[O-])nc(N[C@@H](Cc2ccc(Cl)cc2Cl)C(=O)N[Dy])n1)c1cnccn1
HSA
0
269,651,411
O=C(O)C[C@H](Cc1ccc(F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1(F)CCOC1
Nc1cncc(F)c1
O=C(C[C@H](Cc1ccc(F)cc1)Nc1nc(NCC2(F)CCOC2)nc(Nc2cncc(F)c2)n1)N[Dy]
sEH
0
157,166,085
O=C(Nc1cc(Br)c(Cl)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ccccc1OCCCCN
COc1ccc2nnc(CN)n2n1
COc1ccc2nnc(CNc3nc(NCCCCOc4ccccc4OC)nc(Nc4cc(Br)c(Cl)cc4C(=O)N[Dy])n3)n2n1
BRD4
0
138,396,058
O=C(Nc1c(C(=O)O)ccc2ccccc12)OCC1c2ccccc2-c2ccccc21
CC(C)(C)c1nnc(CN)s1.Cl
NCC1(c2ccc3c(c2)OCO3)CCCCC1
CC(C)(C)c1nnc(CNc2nc(NCC3(c4ccc5c(c4)OCO5)CCCCC3)nc(Nc3c(C(=O)N[Dy])ccc4ccccc34)n2)s1
HSA
0
65,823,333
N#Cc1ccc(C[C@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Cc1sc(CCN)nc1-c1ccccc1.Cl.Cl
Nc1nccnc1Br
Cc1sc(CCNc2nc(Nc3nccnc3Br)nc(N[C@@H](CC(=O)N[Dy])Cc3ccc(C#N)cc3)n2)nc1-c1ccccc1
BRD4
0
69,680,495
N#Cc1ccc([C@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Nc1nc(Cl)ccc1Cl
CC1(C)NC(=O)N(CCCN)C1=O.Cl
CC1(C)NC(=O)N(CCCNc2nc(Nc3nc(Cl)ccc3Cl)nc(N[C@@H](CC(=O)N[Dy])c3ccc(C#N)cc3)n2)C1=O
sEH
0
63,405,221
N#Cc1ccc(C[C@@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
COC1(CN)CCC1
Nc1n[nH]c2cc(F)ccc12
COC1(CNc2nc(Nc3n[nH]c4cc(F)ccc34)nc(N[C@H](CC(=O)N[Dy])Cc3ccc(C#N)cc3)n2)CCC1
sEH
0
282,155,781
O=C(O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1ncccc1CO
Nc1ncnc2[nH]ncc12
O=C(N[Dy])[C@@H]1CCCN1C(=O)[C@@H]1CCCN1c1nc(Nc2ncccc2CO)nc(Nc2ncnc3[nH]ncc23)n1
BRD4
0
34,888,439
COc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1OC
CC(C)(C#N)c1ccc(N)cc1
Cc1ccc(CN)nc1C.Cl.Cl
COc1ccc(C[C@H](Nc2nc(NCc3ccc(C)c(C)n3)nc(Nc3ccc(C(C)(C)C#N)cc3)n2)C(=O)N[Dy])cc1OC
sEH
0