id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
83,530,601
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCC1(CO)CCOC1
NCc1cc2c(s1)CCSC2
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NCc3cc4c(s3)CCSC4)nc(NCC3(CO)CCOC3)n2)CC1
sEH
1
82,157,822
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1sc(C)c(CN)c1Br.Cl
Cc1cc(CN)ccc1Oc1ccc(Cl)cc1Cl.Cl
Cc1cc(CNc2nc(NCc3c(C)sc(C)c3Br)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)ccc1Oc1ccc(Cl)cc1Cl
sEH
1
97,540,295
O=C(N[C@@H](Cc1ccc(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1OCCc2ccsc21
Cl.NCC12CC3CC(CC(C3)C1)C2
O=C(N[Dy])[C@H](Cc1ccc(F)c(F)c1)Nc1nc(NCC2OCCc3ccsc32)nc(NCC23CC4CC(CC(C4)C2)C3)n1
sEH
1
85,057,595
O=C(N[C@@H](C(=O)O)C1CCCC1)OCC1c2ccccc2-c2ccccc21
CC1CN(S(=O)(=O)CCN)CC(C)O1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCCS(=O)(=O)N4CC(C)OC(C)C4)nc(N[C@@H](C(=O)N[Dy])C4CCCC4)n3)ccc2[nH]1
sEH
1
285,141,657
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
NC[C@@H]1CCC(=O)N1
Cl.NCC1Cc2ccccc2NC1=O
O=C1CC[C@@H](CNc2nc(NCC3Cc4ccccc4NC3=O)nc(N3Cc4cc(O)ccc4C[C@H]3C(=O)N[Dy])n2)N1
BRD4
1
275,244,142
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc(Cl)c1Cl
N#Cc1c(N)cccc1F
Cc1cc(N)n[nH]1
Cc1cc(Nc2nc(Nc3cccc(F)c3C#N)nc(N[C@@H](CC(=O)N[Dy])c3cccc(Cl)c3Cl)n2)n[nH]1
HSA
1
16,129,620
CC(C)(C)OC(=O)N1C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)[C@H](C(=O)O)C1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Nc1nc(F)cc(F)n1
CC(C)(C)OC(=O)N1C[C@@H](Nc2nc(Nc3nc(F)cc(F)n3)nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])n2)[C@H](C(=O)N[Dy])C1
BRD4
1
227,268,733
O=C(Nc1nc2ccc(C(=O)O)cc2s1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cocn1
COC(=O)c1cc(Cl)nc(Cl)c1N
COC(=O)c1cc(Cl)nc(Cl)c1Nc1nc(NCc2cocn2)nc(Nc2nc3ccc(C(=O)N[Dy])cc3s2)n1
HSA
1
167,550,457
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)ncn1
Cl.Cl.NCc1cncc(F)c1
O=C(N[Dy])c1ccc(Cl)c(Nc2nc(NCc3cncc(F)c3)nc(Nc3cc(Cl)ncn3)n2)c1
HSA
1
98,866,165
O=C(N[C@@H](Cc1ccc(F)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCc1ccccc1CS(=O)(=O)N1CCOCC1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCc4ccccc4CS(=O)(=O)N4CCOCC4)nc(N[C@@H](Cc4ccc(F)cc4)C(=O)N[Dy])n3)ccc2[nH]1
HSA
1
83,138,093
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(C#N)cnc1N
Cl.NCc1cc(F)c(Cl)cc1F
Cc1cc(C#N)cnc1Nc1nc(NCc2cc(F)c(Cl)cc2F)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
226,663,123
O=C(Nc1nc2ccc(C(=O)O)cc2s1)OCC1c2ccccc2-c2ccccc21
CC(CN)OC(C)(C)C.Cl
Cc1ccc(CN)c(Cl)n1
Cc1ccc(CNc2nc(NCC(C)OC(C)(C)C)nc(Nc3nc4ccc(C(=O)N[Dy])cc4s3)n2)c(Cl)n1
HSA
1
190,226,749
O=C(Nc1ccc(C(=O)O)cc1Cl)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Nc1cn2nc(Cl)ccc2n1
O=C(N[Dy])c1ccc(Nc2nc(NCc3cnc4n3CCOC4)nc(Nc3cn4nc(Cl)ccc4n3)n2)c(Cl)c1
HSA
1
81,798,800
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCC(C)(O)CCN
N#Cc1ccc2nc(N)sc2c1
CCC(C)(O)CCNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2nc3ccc(C#N)cc3s2)n1
sEH
1
82,030,517
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CSSCCN.Cl
N#CC1=C(N)CCC1
CSSCCNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(NC2=C(C#N)CCC2)n1
sEH
1
192,760,510
O=C(Nc1ccc(C(=O)O)cc1O)OCC1c2ccccc2-c2ccccc21
Nc1ccncc1Cl
Cl.Cl.NCc1ccc(O)c2ncccc12
O=C(N[Dy])c1ccc(Nc2nc(NCc3ccc(O)c4ncccc34)nc(Nc3ccncc3Cl)n2)c(O)c1
HSA
1
82,695,851
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O
Cc1sc(CN)nc1C(C)C
Cc1sc(CNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)n2)nc1C(C)C
sEH
1
82,042,970
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1c(N)cccc1F
CN(C)c1cccnc1CN
Cc1c(F)cccc1Nc1nc(NCc2ncccc2N(C)C)nc(NCC2CCC(C(=O)N[Dy])CC2)n1
sEH
1
207,903,505
O=C(Nc1cccc(-c2cccc(C(=O)O)c2)c1O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
CCOC(=O)c1nnc(N)o1
CCOC(=O)c1nnc(Nc2nc(Nc3ccc(Cn4ccnc4)cc3)nc(Nc3cccc(-c4cccc(C(=O)N[Dy])c4)c3O)n2)o1
HSA
1
209,653,039
O=C(Nc1cccc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC=Cc1cccnc1
Cl.NCCN1C(=O)SC(=Cc2cccs2)C1=O
O=C(N[Dy])c1cccc(Nc2nc(NCC=Cc3cccnc3)nc(NCCN3C(=O)SC(=Cc4cccs4)C3=O)n2)c1
HSA
1
275,503,122
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc(Cl)c1Cl
Nc1ccc2c(c1)CNC2=O
NCc1ccsc1Br
O=C(C[C@H](Nc1nc(NCc2ccsc2Br)nc(Nc2ccc3c(c2)CNC3=O)n1)c1cccc(Cl)c1Cl)N[Dy]
BRD4
1
28,754,917
COc1c(F)ccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1csc(N)n1
NCc1nccs1
COc1c(F)ccc(C(=O)N[Dy])c1Nc1nc(NCc2nccs2)nc(Nc2nc(C)cs2)n1
HSA
1
172,607,407
O=C(Nc1cc(F)c(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC=Cc1cccnc1
CN1C(=O)Cc2cc(CN)ccc21.Cl
CN1C(=O)Cc2cc(CNc3nc(NCC=Cc4cccnc4)nc(Nc4cc(F)c(Br)cc4C(=O)N[Dy])n3)ccc21
HSA
1
215,559,268
O=C(Nc1cccc([N+](=O)[O-])c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(N2CCOCC2)cn1
CC(O)(CN)c1ccsc1
CC(O)(CNc1nc(Nc2ccc(N3CCOCC3)cn2)nc(Nc2cccc([N+](=O)[O-])c2C(=O)N[Dy])n1)c1ccsc1
HSA
1
17,617,248
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COC(=O)c1ccc(N)cc1OC
CS(=O)(=O)c1ccc(N)cc1
COC(=O)c1ccc(Nc2nc(Nc3ccc(S(C)(=O)=O)cc3)nc(NC(CC(C)C)C(=O)N[Dy])n2)cc1OC
BRD4
1
19,474,968
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1ccc2c(c1)CCC2=O
NCC1CCCn2ccnc21
CC(OC(C)(C)C)C(Nc1nc(NCC2CCCn3ccnc32)nc(Nc2ccc3c(c2)CCC3=O)n1)C(=O)N[Dy]
BRD4
1
260,521,896
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccs1
CN(C)c1ncccc1CN.Cl.Cl
Cn1nccc1[C@@H]1OCC[C@H]1CN
CN(C)c1ncccc1CNc1nc(NC[C@@H]2CCO[C@H]2c2ccnn2C)nc(N[C@H](CC(=O)N[Dy])c2cccs2)n1
BRD4
1
82,579,016
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cc(F)cc(F)c1[N+](=O)[O-]
Nc1cc(-c2ccccc2)[nH]n1
O=C(N[Dy])C1CCC(CNc2nc(Nc3cc(-c4ccccc4)[nH]n3)nc(Nc3cc(F)cc(F)c3[N+](=O)[O-])n2)CC1
sEH
1
260,401,992
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccs1
CC(=O)SCCN.Cl
Cl.Cl.NCc1ncc[nH]1
CC(=O)SCCNc1nc(NCc2ncc[nH]2)nc(N[C@H](CC(=O)N[Dy])c2cccs2)n1
BRD4
1
104,968,012
O=C(N[C@@H](Cc1ccco1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1cc(O)ccc1N
CC(C)c1nc(N)sc1Br
Cc1cc(O)ccc1Nc1nc(Nc2nc(C(C)C)c(Br)s2)nc(N[C@@H](Cc2ccco2)C(=O)N[Dy])n1
HSA
1
128,636,626
O=C(N[C@H]1C=C[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
CC1CCCC(CN)O1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCC4CCCC(C)O4)nc(N[C@H]4C=C[C@@H](C(=O)N[Dy])C4)n3)ccc2[nH]1
HSA
1
208,025,180
O=C(Nc1cccc(-c2cccc(C(=O)O)c2)c1O)OCC1c2ccccc2-c2ccccc21
Nc1cncc(Cl)n1
Cl.NCc1nnc2ncccn12
O=C(N[Dy])c1cccc(-c2cccc(Nc3nc(NCc4nnc5ncccn45)nc(Nc4cncc(Cl)n4)n3)c2O)c1
sEH
1
126,727,986
O=C(N[C@H](Cc1ccccc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1cc(F)ccc1N
Cc1ccsc1CN
Cc1cc(F)ccc1Nc1nc(NCc2sccc2C)nc(N[C@H](Cc2ccccc2Cl)C(=O)N[Dy])n1
BRD4
1
82,389,938
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Nc1ncns1
Cc1csc(N)n1
Cc1csc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3ncns3)n2)n1
sEH
1
17,822,619
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cc1ccc(N)c(Cl)n1
CC(CN)Sc1ccccc1
Cc1ccc(Nc2nc(NCC(C)Sc3ccccc3)nc(NC(CC(C)C)C(=O)N[Dy])n2)c(Cl)n1
BRD4
1
148,459,729
O=C(Nc1c(F)cc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cncc(N)n1
Nc1nc2ccccc2[nH]1
COc1cncc(Nc2nc(Nc3nc4ccccc4[nH]3)nc(Nc3c(F)cc(Br)cc3C(=O)N[Dy])n2)n1
HSA
1
82,007,717
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1nc(Cl)ncc1N
Nc1cccc(OC(F)F)c1
COc1nc(Cl)ncc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2cccc(OC(F)F)c2)n1
sEH
1
192,195,972
O=C(Nc1ccc(C(=O)O)cc1O)OCC1c2ccccc2-c2ccccc21
Cc1nnc(CCCN)s1.Cl
COC(=O)c1scc(C)c1N
COC(=O)c1scc(C)c1Nc1nc(NCCCc2nnc(C)s2)nc(Nc2ccc(C(=O)N[Dy])cc2O)n1
BRD4
1
82,337,756
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCCn1cnc2sccc2c1=O
Cl.NCc1ccc[nH]c1=O
O=C(N[Dy])C1CCC(CNc2nc(NCCn3cnc4sccc4c3=O)nc(NCc3ccc[nH]c3=O)n2)CC1
sEH
1
274,333,251
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(F)cc1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
NCC1CCN(c2ccncc2)CC1
O=C(C[C@H](Nc1nc(NCC2CCN(c3ccncc3)CC2)nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])n1)c1ccc(F)cc1)N[Dy]
BRD4
1
246,445,178
O=C(O)C[C@@H](Cc1ccc(Cl)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
COCc1ccccc1CN
Cc1nnc(N)s1
COCc1ccccc1CNc1nc(Nc2nnc(C)s2)nc(N[C@@H](CC(=O)N[Dy])Cc2ccc(Cl)cc2)n1
sEH
1
113,566,203
O=C(N[C@H](C(=O)O)C1CCCCC1)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cc1OC
Cl.Cl.NCc1cc(Br)cc2cccnc12
COc1ccc(Nc2nc(NCc3cc(Br)cc4cccnc34)nc(N[C@H](C(=O)N[Dy])C3CCCCC3)n2)cc1OC
BRD4
1
258,996,619
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc(Cl)c1
NCc1c(Br)cncc1Br
CSc1nnc(CN)s1
CSc1nnc(CNc2nc(NCc3c(Br)cncc3Br)nc(N[C@H](CC(=O)N[Dy])c3cccc(Cl)c3)n2)s1
HSA
1
71,989,684
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CC1CC(CN)C(C)O1
Nc1n[nH]c2ncccc12
CC1CC(CNc2nc(Nc3n[nH]c4ncccc34)nc(NC(CC3CCCCC3)C(=O)N[Dy])n2)C(C)O1
HSA
1
229,065,468
O=C(Nc1ncc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cccc(-c2cc(N)on2)c1
Br.Br.NCC1CCCN1c1cccnn1
COc1cccc(-c2cc(Nc3nc(NCC4CCCN4c4cccnn4)nc(Nc4ncc(Br)cc4C(=O)N[Dy])n3)on2)c1
BRD4
1
148,856,092
O=C(Nc1c(F)cc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cn1cncc1C(CN)N1CCCC1
Cl.Cl.Cn1cncc1CN
Cn1cncc1CNc1nc(NCC(c2cncn2C)N2CCCC2)nc(Nc2c(F)cc(Br)cc2C(=O)N[Dy])n1
HSA
1
18,805,599
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COc1ccccc1OCCCCN
NCc1cccs1
COc1ccccc1OCCCCNc1nc(NCc2cccs2)nc(NC(C(=O)N[Dy])C(C)OC(C)(C)C)n1
BRD4
1
19,649,211
CCC(C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
CC(C)(CN)C(=O)N1CCCC1
Nc1ccc2c(c1)CNC2=O
CCC(C)C(Nc1nc(NCC(C)(C)C(=O)N2CCCC2)nc(Nc2ccc3c(c2)CNC3=O)n1)C(=O)N[Dy]
BRD4
1
81,794,468
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC1CN(S(=O)(=O)CCN)CC(C)O1
Nc1cc(Br)ccn1
CC1CN(S(=O)(=O)CCNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3cc(Br)ccn3)n2)CC(C)O1
sEH
1
198,073,992
O=C(Nc1ccc(Cl)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
NCc1cn2cccc(F)c2n1
O=C(N[Dy])c1cc(Nc2nc(NCc3cn4cccc(F)c4n3)nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])n2)ccc1Cl
BRD4
1
127,249,298
O=C(N[C@H](Cc1ccccc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCCC2)ccn1
Nc1n[nH]c2ccc([N+](=O)[O-])cc12
O=C(N[Dy])[C@@H](Cc1ccccc1Cl)Nc1nc(Nc2cc(N3CCCC3)ccn2)nc(Nc2n[nH]c3ccc([N+](=O)[O-])cc23)n1
sEH
1
99,890,444
O=C(N[C@@H](Cc1ccc(F)cc1F)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCC1CCC(C(F)F)CC1
NCC1CCC(C(F)F)CC1
O=C(N[Dy])[C@H](Cc1ccc(F)cc1F)Nc1nc(NCC2CCC(C(F)F)CC2)nc(NCC2CCC(C(F)F)CC2)n1
sEH
1
83,378,516
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCC=C(Cl)Cl
Cl.Cl.NCCn1cc(C2CC2)nn1
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NCC=C(Cl)Cl)nc(NCCn3cc(C4CC4)nn3)n2)CC1
sEH
1
82,117,556
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1ccccc1-n1nc(C)c(CN)c1C.Cl.Cl
Cl.NCCC1CN(c2ncnc3[nH]ncc23)c2ccccc21
Cc1ccccc1-n1nc(C)c(CNc2nc(NCCC3CN(c4ncnc5[nH]ncc45)c4ccccc43)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)c1C
sEH
1
21,192,252
CCCCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Cl.NCc1cc2n(n1)CCCO2
Nc1ccc2c(c1)CCCC2=O
CCCCC(Nc1nc(NCc2cc3n(n2)CCCO3)nc(Nc2ccc3c(c2)CCCC3=O)n1)C(=O)N[Dy]
BRD4
1
82,141,289
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1nc(Cl)ccc1N
NCCC(O)C1CCCC1
Cc1nc(Cl)ccc1Nc1nc(NCCC(O)C2CCCC2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1
sEH
1
81,716,255
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
C=C(C)COCCN.Cl
Cn1cc(C(F)F)c(CN)n1
C=C(C)COCCNc1nc(NCc2nn(C)cc2C(F)F)nc(NCC2CCC(C(=O)N[Dy])CC2)n1
sEH
1
7,600,543
C=CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1ncc([N+](=O)[O-])s1
Cl.NCc1nnc2ncccn12
C=CCC(Nc1nc(NCc2nnc3ncccn23)nc(Nc2ncc([N+](=O)[O-])s2)n1)C(=O)N[Dy]
HSA
1
8,619,149
C=CCC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cccc2cnccc12
Cl.NCc1nnc2ncccn12
C=CCC[C@@H](Nc1nc(NCc2nnc3ncccn23)nc(Nc2cccc3cnccc23)n1)C(=O)N[Dy]
sEH
1
81,886,139
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(N)ccc1C
Nc1cnc(Cl)cc1Cl
COC(=O)c1cc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3cnc(Cl)cc3Cl)n2)ccc1C
sEH
1
82,141,169
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1nc(Cl)ccc1N
N#Cc1c(N)cccc1F
Cc1nc(Cl)ccc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2cccc(F)c2C#N)n1
sEH
1
72,403,073
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Cc1ccc(CN)c(Cl)n1
Cc1ccc(CNc2nc(NCc3ccc(O)c4ncccc34)nc(NC(CC3CCCCC3)C(=O)N[Dy])n2)c(Cl)n1
sEH
1
42,436,487
CS(=O)(=O)c1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1
Nc1nc(C2CC2)cs1
CCOC(=O)c1ncccc1N
CCOC(=O)c1ncccc1Nc1nc(Nc2nc(C3CC3)cs2)nc(Nc2cc(S(C)(=O)=O)ccc2C(=O)N[Dy])n1
sEH
1
208,017,221
O=C(Nc1cccc(-c2cccc(C(=O)O)c2)c1O)OCC1c2ccccc2-c2ccccc21
Nc1cn[nH]c1
Nc1nc(F)nc2nc[nH]c12
O=C(N[Dy])c1cccc(-c2cccc(Nc3nc(Nc4cn[nH]c4)nc(Nc4nc(F)nc5nc[nH]c45)n3)c2O)c1
sEH
1
82,071,086
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)ccc1F
CCC1COCCN1CCN.Cl.Cl
CCC1COCCN1CCNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2ccc(F)c(C)c2)n1
sEH
1
257,193,555
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Cl)cc1
CC1=CCN(CCN)CC1.Cl.Cl
CC(=O)SCCN.Cl
CC(=O)SCCNc1nc(NCCN2CC=C(C)CC2)nc(N[C@H](CC(=O)N[Dy])c2ccc(Cl)cc2)n1
BRD4
1
74,740,759
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Cl.Cn1c(CN)n[nH]c1=O
Cn1c(CNc2nc(NCc3cnc4n3CCOC4)nc(NC(Cc3ccccc3)C(=O)N[Dy])n2)n[nH]c1=O
HSA
1
94,638,028
O=C(N[C@@H](Cc1ccc(C(F)(F)F)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2[nH]ncc2c1
Cl.NCc1nnc2ncccn12
O=C(N[Dy])[C@H](Cc1ccc(C(F)(F)F)cc1)Nc1nc(NCc2nnc3ncccn23)nc(Nc2ccc3[nH]ncc3c2)n1
HSA
1
18,088,209
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.NCc1cnoc1C1CC1
Cl.NCC1CCCC2(CCC2)C1O
CC(C)CC(Nc1nc(NCc2cnoc2C2CC2)nc(NCC2CCCC3(CCC3)C2O)n1)C(=O)N[Dy]
BRD4
1
214,037,317
O=C(Nc1cccc(I)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Nc1ccc2c(c1)COC2=O
O=C1OCc2cc(Nc3nc(NCc4ccc(O)c5ncccc45)nc(Nc4cccc(I)c4C(=O)N[Dy])n3)ccc21
HSA
1
112,081,680
O=C(N[C@H](C(=O)O)C1CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)COC2=O
NCCc1ncc(Br)s1
O=C1OCc2cc(Nc3nc(NCCc4ncc(Br)s4)nc(N[C@H](C(=O)N[Dy])C4CC4)n3)ccc21
BRD4
1
174,824,350
O=C(Nc1cc(F)cc(F)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Cc1ccsc1CN
Cc1ccsc1CNc1nc(NCc2cncc(F)c2)nc(Nc2cc(F)cc(F)c2C(=O)N[Dy])n1
HSA
1
254,354,339
O=C(O)C[C@@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Cc1cc(N)n[nH]1
Cc1cc(Nc2nc(NCc3cncc(F)c3)nc(N[C@@H](CC(=O)N[Dy])Cc3cccs3)n2)n[nH]1
sEH
1
81,761,240
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(CN)OC(C)(C)C.Cl
COc1cc(C)c(N)cn1
COc1cc(C)c(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NCC(C)OC(C)(C)C)n2)cn1
sEH
1
128,340,942
O=C(N[C@H](Cc1csc2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Nc1ccc(Cl)c(F)c1
O=C(N[Dy])[C@@H](Cc1csc2ccccc12)Nc1nc(Nc2ccc(Cl)c(F)c2)nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])n1
BRD4
1
83,186,915
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1ccc(N)c(CO)c1
NCC(c1cccc(F)c1)N1CCOCC1
Cc1ccc(Nc2nc(NCC(c3cccc(F)c3)N3CCOCC3)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)c(CO)c1
sEH
1
268,630,073
O=C(O)C[C@H](Cc1ccc(Cl)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCCS(=O)(=O)c1ccc(Cl)cc1
COC1(OC)CC(CN)C1
COC1(OC)CC(CNc2nc(NCCS(=O)(=O)c3ccc(Cl)cc3)nc(N[C@H](CC(=O)N[Dy])Cc3ccc(Cl)cc3)n2)C1
sEH
1
81,896,852
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cccc(N)n1
COC1(CN)CCC1
COC(=O)c1cccc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NCC3(OC)CCC3)n2)n1
sEH
1
273,750,005
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(F)cc1
COc1cncc(N)c1
CCOC(=O)c1c[nH]nc1N
CCOC(=O)c1c[nH]nc1Nc1nc(Nc2cncc(OC)c2)nc(N[C@@H](CC(=O)N[Dy])c2ccc(F)cc2)n1
sEH
1
82,107,461
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1ccc(S(C)(=O)=O)cc1N
Cl.NCCCNC(=O)c1ccc(F)cc1
Cc1ccc(S(C)(=O)=O)cc1Nc1nc(NCCCNC(=O)c2ccc(F)cc2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1
sEH
1
57,066,905
Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Cc1ccnc(Cl)c1N
Cl.NCC12CC3CC(CC(C3)C1)C2
Cc1ccc(C[C@H](Nc2nc(NCC34CC5CC(CC(C5)C3)C4)nc(Nc3c(C)ccnc3Cl)n2)C(=O)N[Dy])cc1
sEH
1
58,754,893
Cc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
Nc1ccncc1[N+](=O)[O-]
NCc1cn2cccc(F)c2n1
Cc1ccc(Nc2nc(NCc3cn4cccc(F)c4n3)nc(Nc3ccncc3[N+](=O)[O-])n2)c(C(=O)N[Dy])c1
HSA
1
198,432,372
O=C(Nc1ccc(Cl)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CN1C(=O)Cc2cc(CN)ccc21.Cl
NCc1ccc(CN2CCCC2=O)cc1
CN1C(=O)Cc2cc(CNc3nc(NCc4ccc(CN5CCCC5=O)cc4)nc(Nc4ccc(Cl)cc4C(=O)N[Dy])n3)ccc21
BRD4
1
16,505,658
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
CNC(=O)C(O)CN.Cl
NCc1ccc(Oc2cccnc2)c(F)c1
CNC(=O)C(O)CNc1nc(NCc2ccc(Oc3cccnc3)c(F)c2)nc(NC(COC(C)(C)C)C(=O)N[Dy])n1
BRD4
1
214,241,224
O=C(Nc1cccc(I)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
N#Cc1cc(F)ccc1N
CCOC(=O)c1ncccc1N
CCOC(=O)c1ncccc1Nc1nc(Nc2ccc(F)cc2C#N)nc(Nc2cccc(I)c2C(=O)N[Dy])n1
HSA
1
232,566,419
O=C(O)C1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Nc1ccnc(-c2ccccc2)c1
O=C(N[Dy])C1CCCN1c1nc(NCc2cncc(F)c2)nc(Nc2ccnc(-c3ccccc3)c2)n1
sEH
1
17,360,694
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cnc(Cl)cc1Cl
Cl.Cl.NCC#Cc1cccnc1
CC(C)(C)OCC(Nc1nc(NCC#Cc2cccnc2)nc(Nc2cnc(Cl)cc2Cl)n1)C(=O)N[Dy]
BRD4
1
200,731,230
O=C(Nc1ccc(F)c(C(=O)O)c1F)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cc1OC
CS(=O)(=O)Nc1cccc(N)c1
COc1ccc(Nc2nc(Nc3cccc(NS(C)(=O)=O)c3)nc(Nc3ccc(F)c(C(=O)N[Dy])c3F)n2)cc1OC
BRD4
1
82,412,333
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
N#Cc1cc(N)ccc1Cl
Nc1n[nH]c2c(F)c(F)ccc12
N#Cc1cc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3n[nH]c4c(F)c(F)ccc34)n2)ccc1Cl
sEH
1
188,394,630
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Nc1cccnc1[N+](=O)[O-]
COc1c(F)ccc(F)c1CN.Cl
COc1c(F)ccc(F)c1CNc1nc(Nc2ccc(C(=O)N[Dy])cc2)nc(Nc2cccnc2[N+](=O)[O-])n1
BRD4
1
83,634,152
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1c2c(cc3c1CCC3)CCC2
Cc1cnc(CN)o1.Cl
Cc1cnc(CNc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3c4c(cc5c3CCC5)CCC4)n2)o1
sEH
1
17,457,426
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
CC(C)(C#N)c1ccc(N)cc1
Cl.Cl.NCC(=O)NCCN1CCOCC1
CC(C)CC(Nc1nc(NCC(=O)NCCN2CCOCC2)nc(Nc2ccc(C(C)(C)C#N)cc2)n1)C(=O)N[Dy]
BRD4
1
58,880,578
Cc1cccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
CC(C)c1nnc([C@H]2C[C@H](CN)[C@H](O)C2)[nH]1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NC[C@H]4C[C@H](c5nnc(C(C)C)[nH]5)C[C@H]4O)nc(Nc4c(C)cccc4C(=O)N[Dy])n3)ccc2[nH]1
HSA
1
72,861,852
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CCC2=O
NCC1CCC(F)(F)CC1
O=C1CCc2cc(Nc3nc(NCC4CCC(F)(F)CC4)nc(NC(CC4CCCCC4)C(=O)N[Dy])n3)ccc21
BRD4
1
236,948,718
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
Cl.Cn1nnc(CN)c1C(F)F
COc1ccc(N)cc1OC
COc1ccc(Nc2nc(NCc3nnn(C)c3C(F)F)nc(NC(CC(=O)N[Dy])c3ccc(Br)cc3)n2)cc1OC
BRD4
1
102,193,755
O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
COC(=O)c1cc(N)ccc1Cl
COC(=O)c1cc(Nc2nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])nc(N[C@@H](Cc3ccc([N+](=O)[O-])cc3)C(=O)N[Dy])n2)ccc1Cl
BRD4
1
244,881,826
O=C(O)C[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(-c2ccccc2)[nH]n1
CCOC(=O)c1nnc(N)o1
CCOC(=O)c1nnc(Nc2nc(Nc3cc(-c4ccccc4)[nH]n3)nc(N[C@@H](CC(=O)N[Dy])Cc3ccc(C(F)(F)F)cc3)n2)o1
HSA
1
82,175,024
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC1CCN(CC(F)F)CC1
NCc1cc(F)cc(F)c1
O=C(N[Dy])C1CCC(CNc2nc(NCc3cc(F)cc(F)c3)nc(NCC3CCN(CC(F)F)CC3)n2)CC1
sEH
1
115,139,700
O=C(N[C@H](C(=O)O)c1ccsc1)OCC1c2ccccc2-c2ccccc21
NCC1CCC(C(F)F)CC1
Nc1ccc2c(c1)CNC2=O
O=C1NCc2cc(Nc3nc(NCC4CCC(C(F)F)CC4)nc(N[C@H](C(=O)N[Dy])c4ccsc4)n3)ccc21
BRD4
1
82,401,842
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cn1ncc2cc(N)ccc21
Nc1nc(-c2ccccc2Cl)cs1
Cn1ncc2cc(Nc3nc(NCC4CCC(C(=O)N[Dy])CC4)nc(Nc4nc(-c5ccccc5Cl)cs4)n3)ccc21
sEH
1