id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
182,057,567
O=C(Nc1ccc(C(=O)O)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1ncccc1N
Nc1nc2cc(Br)ccn2n1
CCOC(=O)c1ncccc1Nc1nc(Nc2ccc(C(=O)N[Dy])c(C(=O)O)c2)nc(Nc2nc3cc(Br)ccn3n2)n1
sEH
1
221,637,403
O=C(Nc1cnccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC=Cc1cccnc1
N#Cc1ccnc(N)c1
N#Cc1ccnc(Nc2nc(NCC=Cc3cccnc3)nc(Nc3cnccc3C(=O)N[Dy])n2)c1
HSA
1
193,494,358
O=C(Nc1ccc(C(=O)O)cc1OC(F)(F)F)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
COc1cncc(N)c1
COc1cncc(Nc2nc(NCc3cnc4n3CCOC4)nc(Nc3ccc(C(=O)N[Dy])cc3OC(F)(F)F)n2)c1
HSA
1
63,211,896
N#Cc1ccc(C[C@@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
CC(=O)SCCN.Cl
NCc1ccc(NC(=O)c2ccco2)cc1
CC(=O)SCCNc1nc(NCc2ccc(NC(=O)c3ccco3)cc2)nc(N[C@H](CC(=O)N[Dy])Cc2ccc(C#N)cc2)n1
BRD4
1
62,463,522
Cn1cc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)c2ccccc21
Cc1cc(N)ccc1F
COc1nc(C)ccc1CN
COc1nc(C)ccc1CNc1nc(Nc2ccc(F)c(C)c2)nc(N[C@H](Cc2cn(C)c3ccccc23)C(=O)N[Dy])n1
BRD4
1
192,404,687
O=C(Nc1ccc(C(=O)O)cc1O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
CS(=O)CC(O)CN.Cl
CS(=O)CC(O)CNc1nc(NCc2cnc3n2CCOC3)nc(Nc2ccc(C(=O)N[Dy])cc2O)n1
sEH
1
82,147,460
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1ncccc1N
Cn1nccc1[C@@H]1OCC[C@H]1CN
Cc1ncccc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(NC[C@@H]2CCO[C@H]2c2ccnn2C)n1
sEH
1
273,987,981
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(F)cc1
Cl.Cn1cc(N)ccc1=O
Nc1n[nH]c2ccc([N+](=O)[O-])cc12
Cn1cc(Nc2nc(Nc3n[nH]c4ccc([N+](=O)[O-])cc34)nc(N[C@@H](CC(=O)N[Dy])c3ccc(F)cc3)n2)ccc1=O
BRD4
1
248,653,915
O=C(O)C[C@@H](Cc1ccc(F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
COc1ccc(CN)c(C)c1OC
CC(C)(C)c1cc(N)n[nH]1
COc1ccc(CNc2nc(Nc3cc(C(C)(C)C)[nH]n3)nc(N[C@@H](CC(=O)N[Dy])Cc3ccc(F)cc3)n2)c(C)c1OC
HSA
1
273,610,310
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(F)cc1
CN1CCN(CCN)CC1
Cl.Cl.NCc1cncc(F)c1
CN1CCN(CCNc2nc(NCc3cncc(F)c3)nc(N[C@@H](CC(=O)N[Dy])c3ccc(F)cc3)n2)CC1
sEH
1
18,698,124
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COC(=O)c1cc(N)ccc1Cl
COC(=O)c1sc(-c2ccc(Cl)cc2)cc1N
COC(=O)c1cc(Nc2nc(Nc3cc(-c4ccc(Cl)cc4)sc3C(=O)OC)nc(NC(C(=O)N[Dy])C(C)OC(C)(C)C)n2)ccc1Cl
BRD4
1
82,015,034
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CS(=O)(=O)NC1CCCC1CN.Cl
COc1cccc(N)n1
COc1cccc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NCC3CCCC3NS(C)(=O)=O)n2)n1
sEH
1
74,419,575
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1c(N)cccc1Br
Cl.Cn1cc(N)ccc1=O
Cc1c(Br)cccc1Nc1nc(Nc2ccc(=O)n(C)c2)nc(NC(Cc2ccccc2)C(=O)N[Dy])n1
BRD4
1
16,850,372
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Cl.NCc1cncc(F)c1
Cl.NCc1nc2ccccc2c(=O)[nH]1
CC(C)(C)OCC(Nc1nc(NCc2cncc(F)c2)nc(NCc2nc3ccccc3c(=O)[nH]2)n1)C(=O)N[Dy]
sEH
1
212,544,822
O=C(Nc1cccc(F)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCC(CN)Oc1ccccc1C.Cl
Nc1ccc(F)c(Cl)c1
CCC(CNc1nc(Nc2ccc(F)c(Cl)c2)nc(Nc2cccc(F)c2C(=O)N[Dy])n1)Oc1ccccc1C
BRD4
1
55,376,957
Cc1ccc(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
Cl.Cl.Cn1ccnc1Cn1c(CCCN)nc2c1CCCC2
Cc1ccc(C(=O)N[Dy])cc1Nc1nc(NCCCc2nc3c(n2Cc2nccn2C)CCCC3)nc(Nc2ccc(Cn3ccnc3)cc2)n1
sEH
1
82,975,187
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(N)ccc1F
COc1cccc(-c2cc(N)on2)c1
COC(=O)c1cc(Nc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3cc(-c4cccc(OC)c4)no3)n2)ccc1F
sEH
1
280,409,926
O=C(O)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Cc1ccncc1N
COC(=O)c1ccc2nc(N)sc2c1
COC(=O)c1ccc2nc(Nc3nc(Nc4cnccc4C)nc(N4CCC[C@H]4C(=O)N[Dy])n3)sc2c1
HSA
1
81,935,474
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COCc1ccc(N)cc1
Nc1ncccc1C=O
COCc1ccc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3ncccc3C=O)n2)cc1
sEH
1
44,144,198
C[C@@H](OCc1ccccc1)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.NCC1CCC2(CCC2)CO1
Cc1nnsc1CN
Cc1nnsc1CNc1nc(NCC2CCC3(CCC3)CO2)nc(N[C@H](C(=O)N[Dy])[C@@H](C)OCc2ccccc2)n1
sEH
1
165,502,522
O=C(Nc1cc(C(=O)O)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2cnccc12
Nc1cccc2ocnc12
O=C(N[Dy])c1ccc(C(=O)O)c(Nc2nc(Nc3cccc4cnccc34)nc(Nc3cccc4ocnc34)n2)c1
HSA
1
117,558,682
O=C(N[C@H](CCC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2cnccc12
NCc1cccs1
O=C(N[Dy])[C@@H](CCC1CCCCC1)Nc1nc(NCc2cccs2)nc(Nc2cccc3cnccc23)n1
HSA
1
183,540,800
O=C(Nc1ccc(C(=O)O)c(C(F)(F)F)c1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Cl.Cl.NCC#Cc1cccnc1
O=C(N[Dy])c1ccc(Nc2nc(NCC#Cc3cccnc3)nc(NCc3cncc(F)c3)n2)cc1C(F)(F)F
sEH
1
203,602,089
O=C(Nc1ccc(I)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNC2=O
Nc1cc[nH]c(=O)c1
O=C1NCc2cc(Nc3nc(Nc4cc[nH]c(=O)c4)nc(Nc4ccc(I)cc4C(=O)N[Dy])n3)ccc21
BRD4
1
82,214,660
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cn[nH]c1
Cn1ccc(N)n1
Cn1ccc(Nc2nc(NCc3cn[nH]c3)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)n1
sEH
1
82,500,434
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NC[C@]1(CO)COC[C@H]2CCCN21
Nc1[nH]c(=O)ncc1F
O=C(N[Dy])C1CCC(CNc2nc(NC[C@]3(CO)COC[C@H]4CCCN43)nc(Nc3[nH]c(=O)ncc3F)n2)CC1
sEH
1
82,340,681
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NC[C@@H]1CCCO1
CCOC(=O)c1csc(N)n1
CCOC(=O)c1csc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NC[C@@H]3CCCO3)n2)n1
sEH
1
253,887,878
O=C(O)C[C@@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
CC(C)(CN)CCC#N
NCC1(Cc2ccccc2)CC1
CC(C)(CCC#N)CNc1nc(NCC2(Cc3ccccc3)CC2)nc(N[C@@H](CC(=O)N[Dy])Cc2cccs2)n1
sEH
1
102,591,543
O=C(N[C@@H](Cc1ccccc1F)C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1ccc(N)cc1C
NCc1cccnc1OC(F)F
COC(=O)c1ccc(Nc2nc(NCc3cccnc3OC(F)F)nc(N[C@@H](Cc3ccccc3F)C(=O)N[Dy])n2)cc1C
BRD4
1
238,406,611
O=C(O)CC1(CNC(=O)OCC2c3ccccc3-c3ccccc32)CCCCC1
Nc1ccc(Cn2ccnc2)cc1
Cl.Cl.NCc1cncc(F)c1
O=C(CC1(CNc2nc(NCc3cncc(F)c3)nc(Nc3ccc(Cn4ccnc4)cc3)n2)CCCCC1)N[Dy]
HSA
1
153,594,187
O=C(Nc1c(I)c(C(=O)O)c(I)c(C(=O)O)c1I)OCC1c2ccccc2-c2ccccc21
Nc1ncccc1CO
Cl.NCc1nnc2ncccn12
O=C(O)c1c(I)c(Nc2nc(NCc3nnc4ncccn34)nc(Nc3ncccc3CO)n2)c(I)c(C(=O)N[Dy])c1I
HSA
1
83,580,308
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCCc1ccncc1F
Cl.NCc1nc2ccccc2c(=O)[nH]1
O=c1[nH]c(CNc2nc(NCCc3ccncc3F)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)nc2ccccc12
sEH
1
66,638,137
N#Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
COC(=O)c1cc(N)ccc1Cl
NCc1ccon1
COC(=O)c1cc(Nc2nc(NCc3ccon3)nc(N[C@@H](Cc3ccc(C#N)cc3)C(=O)N[Dy])n2)ccc1Cl
HSA
1
208,205,222
O=C(Nc1cccc(Br)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1ncccc1N
Cc1ccc(C)c(CN)n1
CCOC(=O)c1ncccc1Nc1nc(NCc2nc(C)ccc2C)nc(Nc2cccc(Br)c2C(=O)N[Dy])n1
sEH
1
271,785,335
O=C(O)C[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
CC12CCC(CN)(C1)OC2.Cl
CC12CCC(CNc3nc(NCc4cncc(F)c4)nc(N[C@H](CC(=O)N[Dy])Cc4ccc([N+](=O)[O-])cc4)n3)(C1)OC2
sEH
1
276,432,735
O=C(O)C[C@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
NCc1c[nH]c2ccccc12
COc1ccc2nnc(CN)n2n1
COc1ccc2nnc(CNc3nc(NCc4c[nH]c5ccccc45)nc(N4CCC[C@@H]4CC(=O)N[Dy])n3)n2n1
BRD4
1
284,966,832
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCCNC(=O)c1ccn[nH]1
Nc1c(O)ncnc1O
O=C(NCCNc1nc(Nc2c(O)ncnc2O)nc(N2Cc3cc(O)ccc3C[C@H]2C(=O)N[Dy])n1)c1ccn[nH]1
BRD4
1
82,082,570
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)ncc1[N+](=O)[O-]
CCc1cc(N)n[nH]1
CCc1cc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3cc(C)c([N+](=O)[O-])cn3)n2)n[nH]1
sEH
1
258,370,530
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc(Cl)c1
CNC(=O)c1ccc(N)cc1F
CC1(C)NC(=O)N(CCCN)C1=O.Cl
CNC(=O)c1ccc(Nc2nc(NCCCN3C(=O)NC(C)(C)C3=O)nc(N[C@H](CC(=O)N[Dy])c3cccc(Cl)c3)n2)cc1F
BRD4
1
213,561,027
O=C(Nc1cccc(I)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
CC(=O)SCCN.Cl
CCOC(=O)c1cnc(N)[nH]1
CCOC(=O)c1cnc(Nc2nc(NCCSC(C)=O)nc(Nc3cccc(I)c3C(=O)N[Dy])n2)[nH]1
BRD4
1
163,586,448
O=C(Nc1cc(C(=O)O)ccc1Br)OCC1c2ccccc2-c2ccccc21
CNC(=O)c1ccc(N)cc1F
CCSc1ccc(CN)cc1
CCSc1ccc(CNc2nc(Nc3ccc(C(=O)NC)c(F)c3)nc(Nc3cc(C(=O)N[Dy])ccc3Br)n2)cc1
BRD4
1
31,379,991
COc1cc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)cn1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Cc1cc(N)ncn1
COc1cc(C(=O)N[Dy])c(Nc2nc(Nc3cc(C)ncn3)nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])n2)cn1
BRD4
1
229,606,263
O=C(Nc1ncc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
NCc1ccccc1CS(=O)(=O)N1CCOCC1
Cl.Cn1cc(N)ccc1=O
Cn1cc(Nc2nc(NCc3ccccc3CS(=O)(=O)N3CCOCC3)nc(Nc3ncc(Br)cc3C(=O)N[Dy])n2)ccc1=O
BRD4
1
272,761,598
O=C(O)C[C@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1ccc(N)cc1Br
NCC1CCC(C(F)F)CC1
Cc1ccc(Nc2nc(NCC3CCC(C(F)F)CC3)nc(N[C@H](CC(=O)N[Dy])Cc3cccs3)n2)cc1Br
sEH
1
255,786,165
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
Nc1cc(Cl)c(F)c(Cl)c1
Cc1ccsc1CN
Cc1ccsc1CNc1nc(Nc2cc(Cl)c(F)c(Cl)c2)nc(N[C@H](CC(=O)N[Dy])c2ccc(Br)cc2)n1
BRD4
1
82,663,700
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CCCC2=O
NCCc1ncc(Br)s1
O=C1CCCc2cc(Nc3nc(NCCc4ncc(Br)s4)nc(NCC4CCC(C(=O)N[Dy])CC4)n3)ccc21
sEH
1
102,796,043
O=C(N[C@@H](Cc1ccccc1F)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1ccc(C#N)cc1N
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(Nc4cc(C#N)ccc4C)nc(N[C@@H](Cc4ccccc4F)C(=O)N[Dy])n3)ccc2[nH]1
sEH
1
126,567,646
O=C(N[C@H](Cc1ccccc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cncc(N)c1
Cl.NCCS(=O)(=O)Nc1ccccc1
COC(=O)c1cncc(Nc2nc(NCCS(=O)(=O)Nc3ccccc3)nc(N[C@H](Cc3ccccc3Cl)C(=O)N[Dy])n2)c1
HSA
1
203,589,035
O=C(Nc1ccc(I)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc([N+](=O)[O-])cn1
Cl.NCC12CC3CC(CC(C3)C1)C2
O=C(N[Dy])c1cc(I)ccc1Nc1nc(NCC23CC4CC(CC(C4)C2)C3)nc(Nc2ccc([N+](=O)[O-])cn2)n1
sEH
1
229,085,742
O=C(Nc1ncc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1nc(Br)ccc1N
Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O
COc1nc(Br)ccc1Nc1nc(Nc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)nc(Nc2ncc(Br)cc2C(=O)N[Dy])n1
BRD4
1
257,282,718
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Cl)cc1
CNC(=O)c1ccc(N)cc1F
N#CC1=C(N)CCC1
CNC(=O)c1ccc(Nc2nc(NC3=C(C#N)CCC3)nc(N[C@H](CC(=O)N[Dy])c3ccc(Cl)cc3)n2)cc1F
BRD4
1
18,362,808
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1ccc(O)cc1C(F)(F)F
Nc1[nH]c(=O)ncc1F
CC(C)CC(Nc1nc(Nc2ccc(O)cc2C(F)(F)F)nc(Nc2[nH]c(=O)ncc2F)n1)C(=O)N[Dy]
BRD4
1
82,063,130
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(F)ccc1N
Nc1cn[nH]c1
Cc1cc(F)ccc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2cn[nH]c2)n1
sEH
1
273,215,122
O=C(O)C[C@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1
NCCc1ccc(N2CCOCC2)c(F)c1
O=C(C[C@H](Cc1cccs1)Nc1nc(NCCc2ccc(N3CCOCC3)c(F)c2)nc(Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)N[Dy]
HSA
1
280,985,624
O=C(O)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2cnccc12
CCSc1ccc(CN)cc1
CCSc1ccc(CNc2nc(Nc3cccc4cnccc34)nc(N3CCC[C@H]3C(=O)N[Dy])n2)cc1
sEH
1
292,977,614
O=C(O)[C@H]1C[C@H](O)CN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2ocnc12
Cl.NCCN1C(=O)SC(=Cc2cccs2)C1=O
O=C(N[Dy])[C@H]1C[C@H](O)CN1c1nc(NCCN2C(=O)SC(=Cc3cccs3)C2=O)nc(Nc2cccc3ocnc23)n1
sEH
1
83,611,328
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1ccccc1CN1CCCC1=O
NCc1cc(C(F)F)on1
O=C1CCCN1Cc1ccccc1CNc1nc(NCc2cc(C(F)F)on2)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
65,413,747
N#Cc1ccc(C[C@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
CC(C)CC(C)(CN)NC(=O)c1cc(Cl)c(Cl)[nH]1.Cl
CCOC(=O)c1cnn(C)c1N
CCOC(=O)c1cnn(C)c1Nc1nc(NCC(C)(CC(C)C)NC(=O)c2cc(Cl)c(Cl)[nH]2)nc(N[C@@H](CC(=O)N[Dy])Cc2ccc(C#N)cc2)n1
HSA
1
83,049,404
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1cc2c(cc1CN)OCO2
N#Cc1ccnc(N)c1
COc1cc2c(cc1CNc1nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3cc(C#N)ccn3)n1)OCO2
sEH
1
18,620,133
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
CCN1CCN(Cc2ccc(N)nc2)CC1
COc1ccc(N)cc1OC
CCN1CCN(Cc2ccc(Nc3nc(Nc4ccc(OC)c(OC)c4)nc(NC(C(=O)N[Dy])C(C)OC(C)(C)C)n3)nc2)CC1
BRD4
1
260,402,115
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccs1
CC(=O)SCCN.Cl
Cl.NCCNC(N)=O
CC(=O)SCCNc1nc(NCCNC(N)=O)nc(N[C@H](CC(=O)N[Dy])c2cccs2)n1
BRD4
1
81,800,204
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCC(CC)(CN)OC
Cl.Cl.NCC(O)c1ccncc1
CCC(CC)(CNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(NCC(O)c2ccncc2)n1)OC
sEH
1
153,588,316
O=C(Nc1c(I)c(C(=O)O)c(I)c(C(=O)O)c1I)OCC1c2ccccc2-c2ccccc21
Nc1nccc(-c2cccnc2)n1
COC(=O)c1sc(C)cc1N
COC(=O)c1sc(C)cc1Nc1nc(Nc2nccc(-c3cccnc3)n2)nc(Nc2c(I)c(C(=O)O)c(I)c(C(=O)N[Dy])c2I)n1
HSA
1
285,071,631
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
N#Cc1ncc(N)cc1C(F)(F)F
CC(CCN)S(C)=O
CC(CCNc1nc(Nc2cnc(C#N)c(C(F)(F)F)c2)nc(N2Cc3cc(O)ccc3C[C@H]2C(=O)N[Dy])n1)S(C)=O
BRD4
1
81,837,662
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCS(=O)(=O)N1CC(CN)C1.Cl
Nc1nc(-c2ccc(Cl)cc2)cs1
CCS(=O)(=O)N1CC(CNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3nc(-c4ccc(Cl)cc4)cs3)n2)C1
sEH
1
81,816,761
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1cnc(SC)nc1N
Cc1nc(N)ccc1[N+](=O)[O-]
CCOC(=O)c1cnc(SC)nc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2ccc([N+](=O)[O-])c(C)n2)n1
sEH
1
82,757,759
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ncc(Cl)c(Cl)n1
CCOC(=O)c1cnn(C)c1N
CCOC(=O)c1cnn(C)c1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2ncc(Cl)c(Cl)n2)n1
sEH
1
82,386,824
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Nc1ccc(O)cc1Cl
NCc1nc(-c2ccsc2)no1
O=C(N[Dy])C1CCC(CNc2nc(NCc3nc(-c4ccsc4)no3)nc(Nc3ccc(O)cc3Cl)n2)CC1
sEH
1
213,708,507
O=C(Nc1cccc(I)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
CNC(=O)c1ccc(N)cc1F
Cc1cc(Cl)nc(Cl)c1N
CNC(=O)c1ccc(Nc2nc(Nc3cccc(I)c3C(=O)N[Dy])nc(Nc3c(C)cc(Cl)nc3Cl)n2)cc1F
BRD4
1
82,185,137
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCCNC(=O)c1cnccn1
Cc1nc(CCN)sc1C
Cc1nc(CCNc2nc(NCCNC(=O)c3cnccn3)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)sc1C
sEH
1
55,327,428
Cc1ccc(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)c(O)c(Cl)c1
NCC1(c2ccc3c(c2)OCO3)CCCCC1
Cc1ccc(C(=O)N[Dy])cc1Nc1nc(NCC2(c3ccc4c(c3)OCO4)CCCCC2)nc(Nc2cc(Cl)c(O)c(Cl)c2)n1
BRD4
1
285,709,929
O=C(O)[C@@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cc1OC
NCc1nc2c(s1)CCCCC2
COc1ccc(Nc2nc(NCc3nc4c(s3)CCCCC4)nc(N3Cc4ccccc4C[C@H]3C(=O)N[Dy])n2)cc1OC
BRD4
1
173,500,476
O=C(Nc1cc(F)c(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ccc(O)c(N)c1
NCc1ccc(CN2CCCC2=O)cc1
COc1ccc(O)c(Nc2nc(NCc3ccc(CN4CCCC4=O)cc3)nc(Nc3cc(F)c(F)cc3C(=O)N[Dy])n2)c1
BRD4
1
208,386,862
O=C(Nc1cccc(Br)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cncc(N)n1
Nc1cc(Br)cn2ccnc12
COc1cncc(Nc2nc(Nc3cccc(Br)c3C(=O)N[Dy])nc(Nc3cc(Br)cn4ccnc34)n2)n1
HSA
1
81,749,741
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(C)(CN)CCC#N
Cl.Cl.NCc1cncc(F)c1
CC(C)(CCC#N)CNc1nc(NCc2cncc(F)c2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1
sEH
1
100,013,874
O=C(N[C@@H](Cc1ccc(F)cc1F)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
CC1(C)CC(CCN)C(=O)N1.Cl
CC1(C)CC(CCNc2nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])nc(N[C@@H](Cc3ccc(F)cc3F)C(=O)N[Dy])n2)C(=O)N1
BRD4
1
119,693,820
O=C(N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2[nH]ncc2c1
Cl.NCCS(=O)(=O)Nc1ccccc1
O=C(N[Dy])[C@@H](Cc1ccc(-c2ccccc2)cc1)Nc1nc(NCCS(=O)(=O)Nc2ccccc2)nc(Nc2ccc3[nH]ncc3c2)n1
BRD4
1
82,357,436
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cccc2cc[nH]c12
COc1ccc(N)nc1
COc1ccc(Nc2nc(NCc3cccc4cc[nH]c34)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)nc1
sEH
1
195,782,402
O=C(Nc1ccc(C(=O)O)nc1)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
Cc1cc(N)n[nH]1
Cc1cc(Nc2nc(NCCC3CSC3)nc(Nc3ccc(C(=O)N[Dy])nc3)n2)n[nH]1
sEH
1
163,566,093
O=C(Nc1cc(C(=O)O)ccc1Br)OCC1c2ccccc2-c2ccccc21
CN1CC(CCN)CC1=O
Nc1nc2c(Br)cccc2s1
CN1CC(CCNc2nc(Nc3nc4c(Br)cccc4s3)nc(Nc3cc(C(=O)N[Dy])ccc3Br)n2)CC1=O
BRD4
1
3,946,958
C#CC[C@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Nc1cc(O)ccn1
Cl.NCC1(O)C2C3CC4C5C3CC2C5C41
C#CC[C@H](CC(=O)N[Dy])Nc1nc(NCC2(O)C3C4CC5C6C4CC3C6C52)nc(Nc2cc(O)ccn2)n1
sEH
1
226,886,083
O=C(Nc1nc2ccc(C(=O)O)cc2s1)OCC1c2ccccc2-c2ccccc21
COc1ccc([N+](=O)[O-])c(N)n1
CCOC(=O)c1cnc(N)[nH]1
CCOC(=O)c1cnc(Nc2nc(Nc3nc4ccc(C(=O)N[Dy])cc4s3)nc(Nc3nc(OC)ccc3[N+](=O)[O-])n2)[nH]1
HSA
1
265,503,245
O=C(O)C[C@H](Cc1ccc(Br)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
COC1(CN)CCOC1.Cl
COC1(CNc2nc(NCCC3CSC3)nc(N[C@H](CC(=O)N[Dy])Cc3ccc(Br)cc3)n2)CCOC1
sEH
1
82,457,084
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCC12CCCC(CO1)C2
NCCC1CCOC1
O=C(N[Dy])C1CCC(CNc2nc(NCCC3CCOC3)nc(NCC34CCCC(CO3)C4)n2)CC1
sEH
1
161,728,838
O=C(Nc1cc(Br)cnc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NC[C@@H]1CCO[C@H]1c1cn[nH]c1
Nc1cncc(F)c1
O=C(N[Dy])c1ncc(Br)cc1Nc1nc(NC[C@@H]2CCO[C@H]2c2cn[nH]c2)nc(Nc2cncc(F)c2)n1
sEH
1
104,879,728
O=C(N[C@@H](Cc1ccco1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cncc(N)n1
CC(CN)c1nccs1
COc1cncc(Nc2nc(NCC(C)c3nccs3)nc(N[C@@H](Cc3ccco3)C(=O)N[Dy])n2)n1
HSA
1
81,881,177
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(F)c(F)cc1N
NC[C@@H]1CCC(=O)N1
COC(=O)c1cc(F)c(F)cc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(NC[C@@H]2CCC(=O)N2)n1
sEH
1
218,087,355
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1ccnc(N)c1
COc1ccc(CN)cc1CN1CCOCC1.Cl.Cl
COC(=O)c1ccnc(Nc2nc(NCc3ccc(OC)c(CN4CCOCC4)c3)nc(Nc3ccnc(C(=O)N[Dy])c3)n2)c1
BRD4
1
71,581,822
O=C(CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)OC1CCCCC1
NCCC1CSC1
CCOC(=O)c1c[nH]nc1N
CCOC(=O)c1c[nH]nc1Nc1nc(NCCC2CSC2)nc(N[C@@H](CCC(=O)OC2CCCCC2)C(=O)N[Dy])n1
HSA
1
82,217,945
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cnsc1
Cc1cc(C)c(N)c([N+](=O)[O-])c1
Cc1cc(C)c(Nc2nc(NCc3cnsc3)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)c([N+](=O)[O-])c1
sEH
1
284,434,476
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
CC1CC(CN)C(C)O1
CC1CC(CN)C(C)O1
CC1CC(CNc2nc(NCC3CC(C)OC3C)nc(N3Cc4cc(O)ccc4C[C@H]3C(=O)N[Dy])n2)C(C)O1
BRD4
1
28,592,058
COc1c(F)ccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cc1OC
NCc1nc2ccccc2s1
COc1ccc(Nc2nc(NCc3nc4ccccc4s3)nc(Nc3c(C(=O)N[Dy])ccc(F)c3OC)n2)cc1OC
BRD4
1
83,225,594
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1csc(N)n1
Nc1cc[nH]n1
Cc1csc(Nc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3cc[nH]n3)n2)n1
sEH
1
218,507,130
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.NCCNC(=O)c1ccc(Cl)cc1
COc1nc(C)ccc1CN
COc1nc(C)ccc1CNc1nc(NCCNC(=O)c2ccc(Cl)cc2)nc(Nc2ccnc(C(=O)N[Dy])c2)n1
BRD4
1
203,547,139
O=C(Nc1ccc(I)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
Cl.NCc1nc(-c2ccco2)n[nH]1
O=C(N[Dy])c1cc(I)ccc1Nc1nc(NCc2nc(-c3ccco3)n[nH]2)nc(Nc2ccc(Cn3ccnc3)cc2)n1
HSA
1
103,923,697
O=C(N[C@@H](Cc1cccnc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1cnc(N)cn1
Nc1ncnc2[nH]ncc12
Cc1cnc(Nc2nc(Nc3ncnc4[nH]ncc34)nc(N[C@@H](Cc3cccnc3)C(=O)N[Dy])n2)cn1
HSA
1
67,335,828
N#Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
COC1(OC)CC(CN)C1
COC1(OC)CC(CNc2nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])nc(N[C@@H](Cc3ccc(C#N)cc3)C(=O)N[Dy])n2)C1
BRD4
1
115,663,131
O=C(N[C@H](CC1CCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1ccc(N)cc1OC
COc1cccc(F)c1CN
COC(=O)c1ccc(Nc2nc(NCc3c(F)cccc3OC)nc(N[C@H](CC3CCCC3)C(=O)N[Dy])n2)cc1OC
BRD4
1
82,966,772
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(Cl)ccc1N
Nc1nc2cc(Br)ccn2n1
COC(=O)c1cc(Cl)ccc1Nc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2nc3cc(Br)ccn3n2)n1
sEH
1
50,011,363
Cc1cc(Br)cc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cccc(OC(F)F)c1
Nc1nc2cccc(Br)n2n1
Cc1cc(Br)cc(C(=O)N[Dy])c1Nc1nc(Nc2cccc(OC(F)F)c2)nc(Nc2nc3cccc(Br)n3n2)n1
HSA
1