id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
74,146,432
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CC(CN)c1c(Cl)cccc1Cl
COC(=O)c1ccc2nc(N)sc2c1
COC(=O)c1ccc2nc(Nc3nc(NCC(C)c4c(Cl)cccc4Cl)nc(NC(Cc4ccccc4)C(=O)N[Dy])n3)sc2c1
HSA
1
130,059,424
O=C(N[C@H]1CCC[C@@H]1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1ccncc1N
Cl.Cl.NCc1nccn1-c1ccccc1
Cc1ccncc1Nc1nc(NCc2nccn2-c2ccccc2)nc(N[C@H]2CCC[C@@H]2C(=O)N[Dy])n1
HSA
1
65,121,960
N#Cc1ccc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Nc1c2ccccc2nc2ccccc12
Cl.Cn1cc(N)ccc1=O
Cn1cc(Nc2nc(Nc3c4ccccc4nc4ccccc34)nc(N[C@H](Cc3ccc(C#N)cc3)C(=O)N[Dy])n2)ccc1=O
BRD4
1
82,513,574
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1cc(F)cc(F)c1
NCC1CCCn2ccnc21
O=C(N[Dy])C1CCC(CNc2nc(NCc3cc(F)cc(F)c3)nc(NCC3CCCn4ccnc43)n2)CC1
sEH
1
237,373,713
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
Nc1ccc2c(c1)CNC2=O
CC(C)(C)OC(=O)N1CCC(n2cc(N)cn2)CC1
CC(C)(C)OC(=O)N1CCC(n2cc(Nc3nc(Nc4ccc5c(c4)CNC5=O)nc(NC(CC(=O)N[Dy])c4ccc(Br)cc4)n3)cn2)CC1
BRD4
1
82,334,768
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCCc1cc(Br)c(Br)s1
Cl.Cl.NCc1ccc2scnc2c1
O=C(N[Dy])C1CCC(CNc2nc(NCCc3cc(Br)c(Br)s3)nc(NCc3ccc4scnc4c3)n2)CC1
sEH
1
126,738,012
O=C(N[C@H](Cc1ccccc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)ccc1O
Br.NCc1cccc(Br)n1
Cc1cc(Nc2nc(NCc3cccc(Br)n3)nc(N[C@H](Cc3ccccc3Cl)C(=O)N[Dy])n2)ccc1O
BRD4
1
81,924,041
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC1(CN)CCOC1.Cl
Cc1[nH][nH]c(=O)c1CCN
COC1(CNc2nc(NCCc3c(C)[nH][nH]c3=O)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)CCOC1
sEH
1
269,201,316
O=C(O)C[C@H](Cc1ccc(F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1ccc(O)c(N)c1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
CCOC(=O)c1ccc(O)c(Nc2nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])nc(N[C@H](CC(=O)N[Dy])Cc3ccc(F)cc3)n2)c1
BRD4
1
81,973,043
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cc1Cl.Cl
CO[C@@H]1COC[C@H]1n1cc(CN)nn1.Cl
COc1ccc(Nc2nc(NCc3cn([C@@H]4COC[C@H]4OC)nn3)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)cc1Cl
sEH
1
294,668,498
[N-]=[N+]=NCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Cl.NCc1cncc(F)c1
Cn1cc(C(F)F)c(CN)n1
Cn1cc(C(F)F)c(CNc2nc(NCc3cncc(F)c3)nc(N[C@@H](CCCN=[N+]=[N-])C(=O)N[Dy])n2)n1
sEH
1
111,159,858
O=C(N[C@H](C(=O)O)C1CC1)OCC1c2ccccc2-c2ccccc21
CC(C)(C)c1ocnc1CN.Cl
Nc1ccc2c(c1)CNC2=O
CC(C)(C)c1ocnc1CNc1nc(Nc2ccc3c(c2)CNC3=O)nc(N[C@H](C(=O)N[Dy])C2CC2)n1
BRD4
1
167,591,696
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
Nc1nc(=O)[nH]cc1Br
O=C(N[Dy])c1ccc(Cl)c(Nc2nc(Nc3ccc(Cn4ccnc4)cc3)nc(Nc3nc(=O)[nH]cc3Br)n2)c1
sEH
1
31,209,130
COc1cc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)cn1
N#Cc1cc(N)ccc1F
COC(=O)c1scc(C)c1N
COC(=O)c1scc(C)c1Nc1nc(Nc2ccc(F)c(C#N)c2)nc(Nc2cnc(OC)cc2C(=O)N[Dy])n1
HSA
1
82,379,192
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1nnc2c(=O)[nH]ccn12
CSc1nnc(CN)s1
CSc1nnc(CNc2nc(NCc3nnc4c(=O)[nH]ccn34)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)s1
sEH
1
154,570,137
O=C(Nc1c(I)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNC2=O
COc1cc(CN)sn1.Cl.Cl
COc1cc(CNc2nc(Nc3ccc4c(c3)CNC4=O)nc(Nc3c(I)cccc3C(=O)N[Dy])n2)sn1
BRD4
1
98,619,324
O=C(N[C@@H](Cc1ccc(F)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CCCOC1
Cl.Cn1cc(N)ccc1=O
Cn1cc(Nc2nc(NCC3CCCOC3)nc(N[C@@H](Cc3ccc(F)cc3)C(=O)N[Dy])n2)ccc1=O
BRD4
1
83,217,548
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cnc(Cl)cc1N
Cl.NCC1CCCC1
Cc1cnc(Cl)cc1Nc1nc(NCC2CCCC2)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
18,545,970
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
CC(C)(C#N)c1ccc(N)cc1
CN1CC(CCN)CC1=O
CC(OC(C)(C)C)C(Nc1nc(NCCC2CC(=O)N(C)C2)nc(Nc2ccc(C(C)(C)C#N)cc2)n1)C(=O)N[Dy]
BRD4
1
81,842,690
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCn1cc2cc(N)ccc2n1
CCC(C)(O)CCN
CCn1cc2cc(Nc3nc(NCCC(C)(O)CC)nc(NCC4CCC(C(=O)N[Dy])CC4)n3)ccc2n1
sEH
1
83,791,688
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cccc2ocnc12
Cl.NC[C@@H]1C[C@@H]2O[C@H]1[C@H]1C[C@H]12
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NC[C@@H]3C[C@@H]4O[C@H]3[C@H]3C[C@H]34)nc(Nc3cccc4ocnc34)n2)CC1
sEH
1
50,165,979
Cc1cc(C(=O)O)ccc1NC(=O)OCC1c2ccccc2-c2ccccc21
CC(CCN)S(C)=O
Nc1nc(Cl)c2[nH]cnc2n1
Cc1cc(C(=O)N[Dy])ccc1Nc1nc(NCCC(C)S(C)=O)nc(Nc2nc(Cl)c3[nH]cnc3n2)n1
BRD4
1
81,800,267
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCC(CC)(CN)OC
Cl.Cl.NCc1ccc2scnc2c1
CCC(CC)(CNc1nc(NCc2ccc3scnc3c2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1)OC
sEH
1
82,219,187
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cnsc1
Nc1cc(Cl)ccn1
O=C(N[Dy])C1CCC(CNc2nc(NCc3cnsc3)nc(Nc3cc(Cl)ccn3)n2)CC1
sEH
1
40,805,384
COc1nccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
CCOC(=O)c1c[nH]nc1N
CCOC(=O)c1c[nH]nc1Nc1nc(NCc2ccc(O)c3ncccc23)nc(Nc2c(C(=O)N[Dy])ccnc2OC)n1
sEH
1
16,128,180
CC(C)(C)OC(=O)N1C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)[C@H](C(=O)O)C1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
CSc1nnc(CN)s1
CSc1nnc(CNc2nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])nc(N[C@@H]3CN(C(=O)OC(C)(C)C)C[C@H]3C(=O)N[Dy])n2)s1
BRD4
1
107,036,596
O=C(N[C@@H](Cc1ccsc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ccc(O)c(N)c1
Nc1ccc2c(c1)CC(=O)N2
COc1ccc(O)c(Nc2nc(Nc3ccc4c(c3)CC(=O)N4)nc(N[C@@H](Cc3ccsc3)C(=O)N[Dy])n2)c1
HSA
1
83,228,528
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1nc(Cl)ccc1N
Cl.NCCOc1ccc(F)c(F)c1
Cc1nc(Cl)ccc1Nc1nc(NCCOc2ccc(F)c(F)c2)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
19,390,065
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cc(F)cc(F)c1[N+](=O)[O-]
Br.Br.NCC1CCCN1c1cccnn1
CC(OC(C)(C)C)C(Nc1nc(NCC2CCCN2c2cccnn2)nc(Nc2cc(F)cc(F)c2[N+](=O)[O-])n1)C(=O)N[Dy]
BRD4
1
257,610,941
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Cl)cc1
Cl.Cl.NCc1ccc(O)c2ncccc12
Nc1nc2c(s1)CCCC2
O=C(C[C@@H](Nc1nc(NCc2ccc(O)c3ncccc23)nc(Nc2nc3c(s2)CCCC3)n1)c1ccc(Cl)cc1)N[Dy]
sEH
1
30,499,042
COc1cc(C(=O)O)c(N)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1nncs1
COC(=O)c1nc(N)sc1Br
COC(=O)c1nc(Nc2nc(Nc3nncs3)nc(Nc3cc(N)c(C(=O)N[Dy])cc3OC)n2)sc1Br
HSA
1
18,922,449
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cc1ccc2cccc(N)c2n1
Nc1ccc2c(c1)CNC2=O
Cc1ccc2cccc(Nc3nc(Nc4ccc5c(c4)CNC5=O)nc(NC(C(=O)N[Dy])C(C)OC(C)(C)C)n3)c2n1
BRD4
1
7,331,659
C=CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCc1c(Br)cncc1Br
NCC1(c2ccc(Cl)cc2Cl)CCCC1
C=CCC(Nc1nc(NCc2c(Br)cncc2Br)nc(NCC2(c3ccc(Cl)cc3Cl)CCCC2)n1)C(=O)N[Dy]
HSA
1
83,581,733
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCCc1coc2ccccc12
Cl.Cl.NCc1nccn1-c1ccccc1
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NCCc3coc4ccccc34)nc(NCc3nccn3-c3ccccc3)n2)CC1
sEH
1
187,830,585
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Cc1ncccc1N
Cc1ccc(CN)c(OC2CCOC2)c1
Cc1ccc(CNc2nc(Nc3ccc(C(=O)N[Dy])cc3)nc(Nc3cccnc3C)n2)c(OC2CCOC2)c1
BRD4
1
72,464,651
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CC(=O)N(Cc2ccccc2)C1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCC4CC(=O)N(Cc5ccccc5)C4)nc(NC(CC4CCCCC4)C(=O)N[Dy])n3)ccc2[nH]1
sEH
1
82,647,626
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1
COc1ncc(N)cc1C(F)(F)F
COc1ncc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3ccc([N+](=O)[O-])c(C(F)(F)F)c3)n2)cc1C(F)(F)F
sEH
1
59,734,825
Cc1cccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
Cl.Cl.NCCC(=O)Nc1ccncc1
Cc1cccc(C(=O)N[Dy])c1Nc1nc(NCCC(=O)Nc2ccncc2)nc(Nc2ccc(Cn3ccnc3)cc2)n1
HSA
1
99,605,447
O=C(N[C@@H](Cc1ccc(F)cc1F)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC1CCN(CC(F)F)CC1
NCc1cc2c(s1)CCSC2
O=C(N[Dy])[C@H](Cc1ccc(F)cc1F)Nc1nc(NCc2cc3c(s2)CCSC3)nc(NCC2CCN(CC(F)F)CC2)n1
sEH
1
20,982,813
CCCCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COc1ccccc1OCCCCN
CN(C)c1ncccc1CN.Cl.Cl
CCCCC(Nc1nc(NCCCCOc2ccccc2OC)nc(NCc2cccnc2N(C)C)n1)C(=O)N[Dy]
BRD4
1
17,234,466
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1ccc(Cl)c(C(F)(F)F)c1
Cc1cnc(F)c(CN)c1
Cc1cnc(F)c(CNc2nc(Nc3ccc(Cl)c(C(F)(F)F)c3)nc(NC(COC(C)(C)C)C(=O)N[Dy])n2)c1
BRD4
1
236,843,686
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
Cc1cnc(N)cn1
Nc1ncnc(=O)[nH]1
Cc1cnc(Nc2nc(Nc3ncnc(=O)[nH]3)nc(NC(CC(=O)N[Dy])c3ccc(Br)cc3)n2)cn1
HSA
1
258,223,449
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc(Cl)c1
CC(=O)SCCN.Cl
CCC(C)(O)CCN
CCC(C)(O)CCNc1nc(NCCSC(C)=O)nc(N[C@H](CC(=O)N[Dy])c2cccc(Cl)c2)n1
BRD4
1
25,098,311
CN(C(=O)OCC1c2ccccc2-c2ccccc21)[C@@H](CC1CCCCC1)C(=O)O
CC(C)(CN)CCC#N
NCC1(Cc2ccccc2)CC1
CN(c1nc(NCC(C)(C)CCC#N)nc(NCC2(Cc3ccccc3)CC2)n1)[C@@H](CC1CCCCC1)C(=O)N[Dy]
sEH
1
82,297,586
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCCC1CCCC1(F)F
Nc1n[nH]c2cc(Cl)ccc12
O=C(N[Dy])C1CCC(CNc2nc(NCCC3CCCC3(F)F)nc(Nc3n[nH]c4cc(Cl)ccc34)n2)CC1
sEH
1
116,445,091
O=C(N[C@H](CC1CCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2cnccc2c1
Cc1ccc([N+](=O)[O-])c(N)n1
Cc1ccc([N+](=O)[O-])c(Nc2nc(Nc3ccc4cnccc4c3)nc(N[C@H](CC3CCCC3)C(=O)N[Dy])n2)n1
HSA
1
54,726,087
Cc1ccc(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
COc1cc(N)ccn1
Nc1ccc2c(c1)CNC2=O
COc1cc(Nc2nc(Nc3ccc4c(c3)CNC4=O)nc(Nc3cc(C(=O)N[Dy])ccc3C)n2)ccn1
BRD4
1
252,072,764
O=C(O)C[C@@H](Cc1cccc(F)c1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1ccccc1-c1csc(N)n1
CC(C)(CN)CCC#N
Cc1ccccc1-c1csc(Nc2nc(NCC(C)(C)CCC#N)nc(N[C@@H](CC(=O)N[Dy])Cc3cccc(F)c3)n2)n1
sEH
1
228,942,910
O=C(Nc1ncc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CN1CCN(CCN)CC1
Cl.NCc1nnc2ncccn12
CN1CCN(CCNc2nc(NCc3nnc4ncccn34)nc(Nc3ncc(Br)cc3C(=O)N[Dy])n2)CC1
HSA
1
183,540,322
O=C(Nc1ccc(C(=O)O)c(C(F)(F)F)c1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
COC(=O)c1c[nH]nc1N
COC(=O)c1c[nH]nc1Nc1nc(NCc2cncc(F)c2)nc(Nc2ccc(C(=O)N[Dy])c(C(F)(F)F)c2)n1
HSA
1
81,947,864
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1cc(C#N)c(F)cc1N
NCC1CS(=O)(=O)c2ccccc21
COc1cc(C#N)c(F)cc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(NCC2CS(=O)(=O)c3ccccc32)n1
sEH
1
125,377,294
O=C(N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CCC(CN)Oc1ccccc1C.Cl
CCOC(=O)c1nonc1N
CCOC(=O)c1nonc1Nc1nc(NCC(CC)Oc2ccccc2C)nc(N[C@H](Cc2ccc([N+](=O)[O-])cc2)C(=O)N[Dy])n1
HSA
1
83,131,886
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1c(N)cccc1F
Nc1cc(C(F)(F)F)cnc1Cl
Cc1c(F)cccc1Nc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2cc(C(F)(F)F)cnc2Cl)n1
sEH
1
289,209,016
O=C(O)[C@H]1CCCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Nc1nc(Br)cn2ccnc12
O=C(N[Dy])[C@H]1CCCCN1c1nc(NCc2ccc(O)c3ncccc23)nc(Nc2nc(Br)cn3ccnc23)n1
HSA
1
19,441,326
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1ccc(N2CCC=C(N3CCOCC3)C2=O)cc1
Cc1cc(N)ccc1F
Cc1cc(Nc2nc(Nc3ccc(N4CCC=C(N5CCOCC5)C4=O)cc3)nc(NC(C(=O)N[Dy])C(C)OC(C)(C)C)n2)ccc1F
BRD4
1
237,292,077
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
CCON(CC)C(=O)CN.Cl
CCON(CC)C(=O)CNc1nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])nc(NC(CC(=O)N[Dy])c2ccc(Br)cc2)n1
BRD4
1
123,613,400
O=C(N[C@H](Cc1ccc(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
NCC1CCC(C(F)F)CC1
O=C(N[Dy])[C@@H](Cc1ccc(F)c(F)c1)Nc1nc(NCc2cncc(F)c2)nc(NCC2CCC(C(F)F)CC2)n1
sEH
1
236,683,041
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
COc1ccc(N)cc1OC
Cc1conc1CN
COc1ccc(Nc2nc(NCc3nocc3C)nc(NC(CC(=O)N[Dy])c3ccc(Br)cc3)n2)cc1OC
BRD4
1
104,152,471
O=C(N[C@@H](Cc1cccnc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Nc1ncc(Cl)c(Cl)n1
O=C(N[Dy])[C@H](Cc1cccnc1)Nc1nc(NCc2cnc3n2CCOC3)nc(Nc2ncc(Cl)c(Cl)n2)n1
HSA
1
103,258,806
O=C(N[C@@H](Cc1ccccc1F)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)c(F)c(Cl)c1
Cl.NCCS(=O)(=O)Nc1ccccc1
O=C(N[Dy])[C@H](Cc1ccccc1F)Nc1nc(NCCS(=O)(=O)Nc2ccccc2)nc(Nc2cc(Cl)c(F)c(Cl)c2)n1
BRD4
1
83,089,040
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1cnc(N)nc1
Nc1n[nH]c2cc(Cl)ccc12
COc1cnc(Nc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3n[nH]c4cc(Cl)ccc34)n2)nc1
sEH
1
180,260,038
O=C(Nc1ccc(Br)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Cn1cc(-c2ccccc2CN)cn1
Cn1cc(-c2ccccc2CNc2nc(NCc3ccc(O)c4ncccc34)nc(Nc3ccc(Br)c(C(=O)N[Dy])c3)n2)cn1
HSA
1
217,960,362
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
CC(F)(F)CN.Cl
NC[C@@H]1CCC(=O)N1
CC(F)(F)CNc1nc(NC[C@@H]2CCC(=O)N2)nc(Nc2ccnc(C(=O)N[Dy])c2)n1
BRD4
1
192,246,496
O=C(Nc1ccc(C(=O)O)cc1O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Cc1ccc(S(C)(=O)=O)cc1N
Cc1ccc(S(C)(=O)=O)cc1Nc1nc(NCc2ccc(O)c3ncccc23)nc(Nc2ccc(C(=O)N[Dy])cc2O)n1
HSA
1
74,332,833
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cc(F)ccc1N
CNC(=O)c1cc(Oc2ccc(N)cc2)ccn1
CNC(=O)c1cc(Oc2ccc(Nc3nc(Nc4ccc(F)cc4OC)nc(NC(Cc4ccccc4)C(=O)N[Dy])n3)cc2)ccn1
BRD4
1
125,070,960
O=C(N[C@H](Cc1ccc(I)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Cl.Cl.NCc1nc2cnccc2s1
O=C(N[Dy])[C@@H](Cc1ccc(I)cc1)Nc1nc(NCc2nc3cnccc3s2)nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])n1
BRD4
1
95,073,932
O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cncc(N)n1
Cl.NCc1ccc(-c2nnn[nH]2)cc1
COc1cncc(Nc2nc(NCc3ccc(-c4nnn[nH]4)cc3)nc(N[C@@H](Cc3ccc(Cl)c(Cl)c3)C(=O)N[Dy])n2)n1
sEH
1
268,330,280
O=C(O)C[C@H](Cc1ccc(Cl)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
CSSCCN.Cl
NCC1(Cc2ccccc2)CC1
CSSCCNc1nc(NCC2(Cc3ccccc3)CC2)nc(N[C@H](CC(=O)N[Dy])Cc2ccc(Cl)cc2)n1
sEH
1
268,686,910
O=C(O)C[C@H](Cc1ccc(Cl)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Nc1ccc(O)cc1Cl
N#Cc1ccsc1N
N#Cc1ccsc1Nc1nc(Nc2ccc(O)cc2Cl)nc(N[C@H](CC(=O)N[Dy])Cc2ccc(Cl)cc2)n1
HSA
1
210,217,726
O=C(Nc1cccc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1nc(-c2cccnc2)cs1
Cl.Cl.NCc1ccc(-n2cncn2)cc1
O=C(N[Dy])c1cccc(Nc2nc(NCc3ccc(-n4cncn4)cc3)nc(Nc3nc(-c4cccnc4)cs3)n2)c1
HSA
1
34,762,807
COc1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1
Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O
Cc1cc2cc(CN)ccc2[nH]1
COc1ccc(C(=O)N[Dy])c(Nc2nc(NCc3ccc4[nH]c(C)cc4c3)nc(Nc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)n2)c1
HSA
1
2,048,871
C#CC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1ccc2c(c1)CNC2=O
NCc1ccc(F)nc1
C#CC[C@@H](Nc1nc(NCc2ccc(F)nc2)nc(Nc2ccc3c(c2)CNC3=O)n1)C(=O)N[Dy]
BRD4
1
259,590,819
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc([N+](=O)[O-])c1
COc1nc(Cl)ncc1N
NCc1ccc(CN2CCCC2=O)cc1
COc1nc(Cl)ncc1Nc1nc(NCc2ccc(CN3CCCC3=O)cc2)nc(N[C@H](CC(=O)N[Dy])c2cccc([N+](=O)[O-])c2)n1
BRD4
1
272,780,932
O=C(O)C[C@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1ccnc(Cl)c1N
Cl.Cl.NCc1ncc[nH]1
Cc1ccnc(Cl)c1Nc1nc(NCc2ncc[nH]2)nc(N[C@H](CC(=O)N[Dy])Cc2cccs2)n1
HSA
1
201,341,583
O=C(Nc1ccc(F)c(C(=O)O)c1F)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Cl.Cn1cc(CN)c(=O)[nH]c1=O
Cn1cc(CNc2nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])nc(Nc3ccc(F)c(C(=O)N[Dy])c3F)n2)c(=O)[nH]c1=O
BRD4
1
113,313,681
O=C(N[C@H](C(=O)O)C1CCCCC1)OCC1c2ccccc2-c2ccccc21
C=CCOC(C)CN
Cl.Cn1cc(N)ccc1=O
C=CCOC(C)CNc1nc(Nc2ccc(=O)n(C)c2)nc(N[C@H](C(=O)N[Dy])C2CCCCC2)n1
BRD4
1
207,510,851
O=C(Nc1cccc(-c2cccc(C(=O)O)c2)c1O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
NCc1cn2cc(Cl)ccc2n1
O=C(N[Dy])c1cccc(-c2cccc(Nc3nc(NCc4cncc(F)c4)nc(NCc4cn5cc(Cl)ccc5n4)n3)c2O)c1
sEH
1
83,633,420
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1c2c(cc3c1CCC3)CCC2
CC1(C)CCOC1CCN
CC1(C)CCOC1CCNc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2c3c(cc4c2CCC4)CCC3)n1
sEH
1
244,010,450
O=C(O)C[C@@H](Cc1ccc(Br)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1ncc([N+](=O)[O-])s1
CC(CN)S(=O)(=O)N1CCN(c2ccccc2)CC1.Cl.Cl
CC(CNc1nc(Nc2ncc([N+](=O)[O-])s2)nc(N[C@@H](CC(=O)N[Dy])Cc2ccc(Br)cc2)n1)S(=O)(=O)N1CCN(c2ccccc2)CC1
sEH
1
55,706,479
Cc1ccc(C(CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
CN(CC(F)(F)F)C(=O)CN.Cl
Cc1cc2cc(CN)ccc2[nH]1
Cc1ccc(C(CC(=O)N[Dy])Nc2nc(NCC(=O)N(C)CC(F)(F)F)nc(NCc3ccc4[nH]c(C)cc4c3)n2)cc1
HSA
1
83,554,952
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCCC(=O)NC1CCCC1
Cc1cc(N)cc(Cl)c1
Cc1cc(Cl)cc(Nc2nc(NCCC(=O)NC3CCCC3)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)c1
sEH
1
58,259,926
Cc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
Cl.Cl.NCc1ncc[nH]1
COc1cncc(N)n1
COc1cncc(Nc2nc(NCc3ncc[nH]3)nc(Nc3ccc(C)cc3C(=O)N[Dy])n2)n1
HSA
1
9,477,163
C=CC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCCC(=O)NC1CCCC1
Nc1nccc(=O)[nH]1
C=CC[C@@H](Nc1nc(NCCC(=O)NC2CCCC2)nc(Nc2nccc(=O)[nH]2)n1)C(=O)N[Dy]
HSA
1
218,624,841
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
NCC(O)COc1ccccc1Br
CC(C)(C)OC(=O)N1CCC(n2cc(N)cn2)CC1
CC(C)(C)OC(=O)N1CCC(n2cc(Nc3nc(NCC(O)COc4ccccc4Br)nc(Nc4ccnc(C(=O)N[Dy])c4)n3)cn2)CC1
BRD4
1
82,276,670
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CCCC1
Nc1cncc(F)c1
O=C(N[Dy])C1CCC(CNc2nc(NCC3CCCC3)nc(Nc3cncc(F)c3)n2)CC1
sEH
1
95,333,492
O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1(O)C2C3CC4C5C3CC2C5C41
Nc1nc2ccc(Cl)cc2s1
O=C(N[Dy])[C@H](Cc1ccc(Cl)c(Cl)c1)Nc1nc(NCC2(O)C3C4CC5C6C4CC3C6C52)nc(Nc2nc3ccc(Cl)cc3s2)n1
sEH
1
123,078,250
O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ncc([N+](=O)[O-])s1
Cl.Cl.NCc1cncc(F)c1
O=C(N[Dy])[C@@H](Cc1ccc(Cl)cc1)Nc1nc(NCc2cncc(F)c2)nc(Nc2ncc([N+](=O)[O-])s2)n1
HSA
1
91,170,059
O=C(N[C@@H](Cc1c(F)c(F)c(F)c(F)c1F)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCC1CC2(CC2)CO1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCC4CC5(CC5)CO4)nc(N[C@@H](Cc4c(F)c(F)c(F)c(F)c4F)C(=O)N[Dy])n3)ccc2[nH]1
sEH
1
214,138,722
O=C(Nc1cccc(I)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCCCNC(=O)C1CCC1
Nc1ccc2c(c1)CNC2=O
O=C1NCc2cc(Nc3nc(NCCCNC(=O)C4CCC4)nc(Nc4cccc(I)c4C(=O)N[Dy])n3)ccc21
BRD4
1
204,537,574
O=C(Nc1ccc([N+](=O)[O-])c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
NCc1cc(=O)c(O)co1
Cc1nnc(N)o1
Cc1nnc(Nc2nc(NCc3cc(=O)c(O)co3)nc(Nc3ccc([N+](=O)[O-])c(C(=O)N[Dy])c3)n2)o1
HSA
1
103,856,099
O=C(N[C@@H](Cc1cccnc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)cc(F)c1
Cl.Cl.NCc1cncc(F)c1
Cc1cc(F)cc(Nc2nc(NCc3cncc(F)c3)nc(N[C@@H](Cc3cccnc3)C(=O)N[Dy])n2)c1
sEH
1
44,429,478
C[C@@H](OCc1ccccc1)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cc(Cl)c(O)c(Cl)c1
CC(CN)c1c(Cl)cccc1Cl
CC(CNc1nc(Nc2cc(Cl)c(O)c(Cl)c2)nc(N[C@H](C(=O)N[Dy])[C@@H](C)OCc2ccccc2)n1)c1c(Cl)cccc1Cl
BRD4
1
139,262,401
O=C(Nc1c(C(=O)O)ccc2ccccc12)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
NCC1CSCCN1Cc1ccccc1
O=C(N[Dy])c1ccc2ccccc2c1Nc1nc(NCC2CSCCN2Cc2ccccc2)nc(Nc2ccc(Cn3ccnc3)cc2)n1
HSA
1
238,539,154
O=C(O)CC1(CNC(=O)OCC2c3ccccc3-c3ccccc32)CCCCC1
Nc1nc(-c2cccnc2)cs1
CCC1=NN(Cc2ccccc2C)C(=O)C1CCN
CCC1=NN(Cc2ccccc2C)C(=O)C1CCNc1nc(NCC2(CC(=O)N[Dy])CCCCC2)nc(Nc2nc(-c3cccnc3)cs2)n1
HSA
1
18,075,396
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.NCc1ccc(-c2c[nH]c(=O)[nH]c2=O)cc1
Cl.NCCNC(=O)c1ccn[nH]1
CC(C)CC(Nc1nc(NCCNC(=O)c2ccn[nH]2)nc(NCc2ccc(-c3c[nH]c(=O)[nH]c3=O)cc2)n1)C(=O)N[Dy]
BRD4
1
83,734,772
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1
CC(CN)c1nccs1
CC(CNc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)n1)c1nccs1
sEH
1
17,107,271
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCCC1CSC1
NCC1CC2(CC2)CO1
CC(C)(C)OCC(Nc1nc(NCCC2CSC2)nc(NCC2CC3(CC3)CO2)n1)C(=O)N[Dy]
sEH
1
82,272,557
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CC2CC1C1CC21
COC(=O)c1cc(N)cc(O)c1
COC(=O)c1cc(O)cc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NCC3CC4CC3C3CC43)n2)c1
sEH
1
284,655,225
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
COc1ncccc1N
Cc1cnc(F)c(CN)c1
COc1ncccc1Nc1nc(NCc2cc(C)cnc2F)nc(N2Cc3cc(O)ccc3C[C@H]2C(=O)N[Dy])n1
BRD4
1
83,368,163
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CCN(c2ccc(Br)cc2)C1
Nc1cc(-c2ccccc2)[nH]n1
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NCC3CCN(c4ccc(Br)cc4)C3)nc(Nc3cc(-c4ccccc4)[nH]n3)n2)CC1
sEH
1