id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
19,290,390
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCCC1SCCS1
NCc1cccc(C(=O)N2CCCC2)c1
CC(OC(C)(C)C)C(Nc1nc(NCCC2SCCS2)nc(NCc2cccc(C(=O)N3CCCC3)c2)n1)C(=O)N[Dy]
BRD4
1
83,233,133
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1ncc(N)cc1Br
Cl.NCC1C=CCC1
Cc1ncc(Nc2nc(NCC3C=CCC3)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)cc1Br
sEH
1
89,984,296
O=C(N[C@@H](CCC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Cc1cc(N)n[nH]1
Cc1cc(Nc2nc(NCc3cnc4n3CCOC4)nc(N[C@@H](CCC3CCCCC3)C(=O)N[Dy])n2)n[nH]1
HSA
1
104,479,207
O=C(N[C@@H](Cc1cccnc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccc(N2CCOCC2)c1
COC(=O)c1sc(-c2ccc(Cl)cc2)cc1N
COC(=O)c1sc(-c2ccc(Cl)cc2)cc1Nc1nc(Nc2cccc(N3CCOCC3)c2)nc(N[C@@H](Cc2cccnc2)C(=O)N[Dy])n1
HSA
1
81,809,132
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCN1CCN(Cc2ccc(N)nc2)CC1
Cl.NCC1CCCC1
CCN1CCN(Cc2ccc(Nc3nc(NCC4CCCC4)nc(NCC4CCC(C(=O)N[Dy])CC4)n3)nc2)CC1
sEH
1
82,438,634
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCC1(CO)CC2C=CC1C2
CN(C)c1ncccc1CN.Cl.Cl
CN(C)c1ncccc1CNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(NCC2(CO)CC3C=CC2C3)n1
sEH
1
152,088,775
O=C(Nc1c(F)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
NCC(O)c1ccc(Cl)s1.O=C(O)C(F)(F)F
O=C(N[Dy])c1cccc(F)c1Nc1nc(NCc2cnc3n2CCOC3)nc(NCC(O)c2ccc(Cl)s2)n1
HSA
1
180,783,664
O=C(Nc1ccc(Br)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1cnc(Cl)cn1
COC(=O)c1c[nH]nc1N
COC(=O)c1c[nH]nc1Nc1nc(Nc2ccc(Br)c(C(=O)N[Dy])c2)nc(Nc2cnc(Cl)cn2)n1
HSA
1
119,595,201
O=C(N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)c(F)c(Cl)c1
CC1(C)CC(CN)C(C)(C)O1
CC1(C)CC(CNc2nc(Nc3cc(Cl)c(F)c(Cl)c3)nc(N[C@H](Cc3ccc(-c4ccccc4)cc3)C(=O)N[Dy])n2)C(C)(C)O1
BRD4
1
274,425,229
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(F)cc1
Nc1ccc2cnccc2c1
CCOC(=O)c1cc(N)[nH]n1
CCOC(=O)c1cc(Nc2nc(Nc3ccc4cnccc4c3)nc(N[C@@H](CC(=O)N[Dy])c3ccc(F)cc3)n2)[nH]n1
HSA
1
200,277,796
O=C(Nc1ccc(Cl)nc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
Cl.Cl.NCC=Cc1cccnc1
O=C(N[Dy])c1nc(Cl)ccc1Nc1nc(NCC=Cc2cccnc2)nc(Nc2ccc(Cn3ccnc3)cc2)n1
HSA
1
65,077,455
N#Cc1ccc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
NCc1c(F)cccc1N1CCCC1
Nc1cccc(OC(F)F)c1
N#Cc1ccc(C[C@@H](Nc2nc(NCc3c(F)cccc3N3CCCC3)nc(Nc3cccc(OC(F)F)c3)n2)C(=O)N[Dy])cc1
BRD4
1
196,041,862
O=C(Nc1ccc(C(=O)O)nc1)OCC1c2ccccc2-c2ccccc21
Nc1cncc(F)c1
Nc1cn2nc(Cl)ccc2n1
O=C(N[Dy])c1ccc(Nc2nc(Nc3cncc(F)c3)nc(Nc3cn4nc(Cl)ccc4n3)n2)cn1
HSA
1
252,175,474
O=C(O)C[C@@H](Cc1cccc(F)c1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
NCC1CCC2CC2C1
O=C(C[C@@H](Cc1cccc(F)c1)Nc1nc(NCc2cncc(F)c2)nc(NCC2CCC3CC3C2)n1)N[Dy]
HSA
1
160,018,878
O=C(Nc1cc(Br)cc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNC2=O
Nc1nc(=O)[nH]cc1Br
O=C(N[Dy])c1cc(Br)cc(Nc2nc(Nc3ccc4c(c3)CNC4=O)nc(Nc3nc(=O)[nH]cc3Br)n2)c1
BRD4
1
123,870,491
O=C(N[C@H](Cc1ccc(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
Nc1cc(Cl)ccc1F
O=C(N[Dy])[C@@H](Cc1ccc(F)c(F)c1)Nc1nc(NCCC2CSC2)nc(Nc2cc(Cl)ccc2F)n1
sEH
1
74,851,985
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
Nc1n[nH]c2cc(F)ccc12
O=C(N[Dy])C(Cc1ccccc1)Nc1nc(NCCC2CSC2)nc(Nc2n[nH]c3cc(F)ccc23)n1
sEH
1
83,719,901
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(N2CCOCC2)c(F)c1
Cc1conc1CN
Cc1conc1CNc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2ccc(N3CCOCC3)c(F)c2)n1
sEH
1
82,033,106
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CSc1ccc(CN)cc1C#N.Cl
Nc1ccc2cc(Br)ccc2c1
CSc1ccc(CNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3ccc4cc(Br)ccc4c3)n2)cc1C#N
sEH
1
157,596,558
O=C(Nc1cc(Br)c(Cl)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
N#Cc1cccnc1N
Cl.NCCS(=O)(=O)Nc1ccccc1
N#Cc1cccnc1Nc1nc(NCCS(=O)(=O)Nc2ccccc2)nc(Nc2cc(Br)c(Cl)cc2C(=O)N[Dy])n1
BRD4
1
240,188,888
O=C(O)CNC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
COc1ccc(N)nc1
COc1ccc(Nc2nc(NCC(=O)N[Dy])nc(NCc3cncc(F)c3)n2)nc1
sEH
1
83,001,980
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(C)(CN)C1CC1
NCc1cc2c(s1)CCSC2
COC(C)(CNc1nc(NCc2cc3c(s2)CCSC3)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1)C1CC1
sEH
1
167,971,051
O=C(Nc1cc(Cl)cc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cncc(N)c1
Cl.NCc1ccc(-c2nnn[nH]2)cc1
COC(=O)c1cncc(Nc2nc(NCc3ccc(-c4nnn[nH]4)cc3)nc(Nc3cc(Cl)cc(C(=O)N[Dy])c3)n2)c1
HSA
1
72,180,919
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ccc(O)c(N)c1
N#Cc1nc[nH]c1N
COc1ccc(O)c(Nc2nc(Nc3[nH]cnc3C#N)nc(NC(CC3CCCCC3)C(=O)N[Dy])n2)c1
HSA
1
159,717,133
O=C(Nc1cc(Br)cc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Nc1ncnc(Cl)c1Cl
O=C(N[Dy])c1cc(Br)cc(Nc2nc(NCc3cnc4n3CCOC4)nc(Nc3ncnc(Cl)c3Cl)n2)c1
HSA
1
139,717,740
O=C(Nc1c(C(=O)O)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cc1[N+](=O)[O-]
Cl.Cl.NCc1nc2c(s1)CCC2
COc1ccc(Nc2nc(NCc3nc4c(s3)CCC4)nc(Nc3c(C(=O)O)cccc3C(=O)N[Dy])n2)cc1[N+](=O)[O-]
BRD4
1
165,162,601
O=C(Nc1cc(C(=O)O)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
CCOC(=O)c1ccc(O)c(N)c1
CCOC(=O)c1ccc(O)c(Nc2nc(NCc3cnc4n3CCOC4)nc(Nc3cc(C(=O)N[Dy])ccc3C(=O)O)n2)c1
HSA
1
163,532,480
O=C(Nc1cc(C(=O)O)ccc1Br)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1ncccc1N
Cc1cc(N)n[nH]1
CCOC(=O)c1ncccc1Nc1nc(Nc2cc(C)[nH]n2)nc(Nc2cc(C(=O)N[Dy])ccc2Br)n1
sEH
1
29,667,729
COc1cc(C(=O)O)c(N)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
COc1cc2c(cc1CN)OCO2
Cl.Cn1cc(N)ccc1=O
COc1cc2c(cc1CNc1nc(Nc3ccc(=O)n(C)c3)nc(Nc3cc(N)c(C(=O)N[Dy])cc3OC)n1)OCO2
BRD4
1
81,774,578
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(O)CCN
CS(=O)(=O)Nc1ccc(-c2csc(N)n2)cc1
CC(O)CCNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2nc(-c3ccc(NS(C)(=O)=O)cc3)cs2)n1
sEH
1
84,414,762
O=C(NCc1cccc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.Cn1cc(N)ccc1=O
COc1nc(C)ccc1CN
COc1nc(C)ccc1CNc1nc(NCc2cccc(C(=O)N[Dy])c2)nc(Nc2ccc(=O)n(C)c2)n1
BRD4
1
87,018,066
O=C(N[C@@H](C(=O)O)C1CCCCC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNC2=O
COC(=O)c1ccsc1N
COC(=O)c1ccsc1Nc1nc(Nc2ccc3c(c2)CNC3=O)nc(N[C@@H](C(=O)N[Dy])C2CCCCC2)n1
BRD4
1
203,140,898
O=C(Nc1ccc(I)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
NCCS(=O)Cc1ccccc1
O=C(N[Dy])c1cc(I)ccc1Nc1nc(NCCS(=O)Cc2ccccc2)nc(NCc2ccc(O)c3ncccc23)n1
sEH
1
159,347,243
O=C(Nc1cc(Br)cc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
COc1ccnc(N)c1
Nc1n[nH]c2ccc([N+](=O)[O-])cc12
COc1ccnc(Nc2nc(Nc3cc(Br)cc(C(=O)N[Dy])c3)nc(Nc3n[nH]c4ccc([N+](=O)[O-])cc34)n2)c1
sEH
1
83,694,248
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cl)nc1
Cl.NCC(F)(F)C(F)(F)F
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NCC(F)(F)C(F)(F)F)nc(Nc3ccc(Cl)nc3)n2)CC1
sEH
1
19,074,314
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.NCC1(O)C2C3CC4C5C3CC2C5C41
Cn1c(=O)cc(N)[nH]c1=O
CC(OC(C)(C)C)C(Nc1nc(NCC2(O)C3C4CC5C6C4CC3C6C52)nc(Nc2cc(=O)n(C)c(=O)[nH]2)n1)C(=O)N[Dy]
sEH
1
82,543,337
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1cn(C(F)F)c2ccccc12
NCc1cnns1
O=C(N[Dy])C1CCC(CNc2nc(NCc3cnns3)nc(NCc3cn(C(F)F)c4ccccc34)n2)CC1
sEH
1
240,654,871
O=C(O)CNC(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2ncoc2c1
Cl.NCc1ccnc(C(N)=O)c1
NC(=O)c1cc(CNc2nc(NCC(=O)N[Dy])nc(Nc3ccc4ncoc4c3)n2)ccn1
HSA
1
253,315,010
O=C(O)C[C@@H](Cc1ccccc1Cl)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CC(=O)N(Cc2ccccc2)C1
Nc1ccc(Br)c(F)n1
O=C(C[C@@H](Cc1ccccc1Cl)Nc1nc(NCC2CC(=O)N(Cc3ccccc3)C2)nc(Nc2ccc(Br)c(F)n2)n1)N[Dy]
sEH
1
285,438,011
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1nncs1
NCc1nc2ccccc2s1
O=C(N[Dy])[C@@H]1Cc2ccc(O)cc2CN1c1nc(NCc2nc3ccccc3s2)nc(Nc2nncs2)n1
sEH
1
81,956,000
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1cc(F)ccc1N
Cl.NCC1CCC2(CCC2)CO1
COc1cc(F)ccc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(NCC2CCC3(CCC3)CO2)n1
sEH
1
258,078,423
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Cl)cc1
Nc1ccc2c(c1)OCO2
NCc1cc2c(s1)CCSC2
O=C(C[C@@H](Nc1nc(NCc2cc3c(s2)CCSC3)nc(Nc2ccc3c(c2)OCO3)n1)c1ccc(Cl)cc1)N[Dy]
BRD4
1
82,356,647
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1ccc[nH]c1=O
Cc1ccc(N)c(CO)c1
Cc1ccc(Nc2nc(NCc3ccc[nH]c3=O)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)c(CO)c1
sEH
1
83,607,785
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1cccc(C(F)(F)F)n1
Nc1cc2cccnc2c2ncccc12
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NCc3cccc(C(F)(F)F)n3)nc(Nc3cc4cccnc4c4ncccc34)n2)CC1
sEH
1
258,712,016
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc(Cl)c1
Cl.Cl.NCc1cncc(F)c1
Nc1n[nH]c2cc(Cl)ccc12
O=C(C[C@@H](Nc1nc(NCc2cncc(F)c2)nc(Nc2n[nH]c3cc(Cl)ccc23)n1)c1cccc(Cl)c1)N[Dy]
sEH
1
81,987,560
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1cccc(F)c1CN
Cl.NCCc1ccno1
COc1cccc(F)c1CNc1nc(NCCc2ccno2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1
sEH
1
54,733,203
Cc1ccc(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
COc1ccc(CN)c(C)c1OC
Nc1ccc2c(c1)COC2=O
COc1ccc(CNc2nc(Nc3ccc4c(c3)COC4=O)nc(Nc3cc(C(=O)N[Dy])ccc3C)n2)c(C)c1OC
BRD4
1
166,770,345
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
CC1CC(CN)C(C)O1
Nc1ccc2c(c1)CNC2=O
CC1CC(CNc2nc(Nc3ccc4c(c3)CNC4=O)nc(Nc3cc(C(=O)N[Dy])ccc3Cl)n2)C(C)O1
BRD4
1
17,456,043
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
CC(=O)c1cccc(N)c1
NCc1ccccc1CN1CCCC1=O
CC(=O)c1cccc(Nc2nc(NCc3ccccc3CN3CCCC3=O)nc(NC(CC(C)C)C(=O)N[Dy])n2)c1
BRD4
1
82,320,737
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCCNC(=O)c1ccn[nH]1
CCC(C)(O)CCN
CCC(C)(O)CCNc1nc(NCCNC(=O)c2ccn[nH]2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1
sEH
1
182,451,295
O=C(Nc1ccc(C(=O)O)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Cl.NCC1CCCC1
O=C(O)c1cc(Nc2nc(NCc3cncc(F)c3)nc(NCC3CCCC3)n2)ccc1C(=O)N[Dy]
HSA
1
233,965,896
O=C(O)C1CCN(C(=O)OCC2c3ccccc3-c3ccccc32)C1
NCc1ccccc1CS(=O)(=O)N1CCOCC1
Nc1ccc2ncccc2c1
O=C(N[Dy])C1CCN(c2nc(NCc3ccccc3CS(=O)(=O)N3CCOCC3)nc(Nc3ccc4ncccc4c3)n2)C1
BRD4
1
289,819,600
O=C(O)[C@H]1CCN1C(=O)OCC1c2ccccc2-c2ccccc21
C=CCSCCN
Nc1nc2ccc(Cl)cc2o1
C=CCSCCNc1nc(Nc2nc3ccc(Cl)cc3o2)nc(N2CC[C@@H]2C(=O)N[Dy])n1
HSA
1
263,589,783
O=C(O)C[C@H](C/C=C/c1ccccc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1nc(-c2ccc(F)cc2)cs1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
O=C(C[C@H](C/C=C/c1ccccc1)Nc1nc(Nc2nc(-c3ccc(F)cc3)cs2)nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])n1)N[Dy]
BRD4
1
22,802,941
CCOc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(Cl)cc1C(=O)O
Nc1cn[nH]c1
NCCc1ncc(Br)s1
CCOc1cc(Nc2nc(NCCc3ncc(Br)s3)nc(Nc3cn[nH]c3)n2)c(Cl)cc1C(=O)N[Dy]
HSA
1
108,479,450
O=C(N[C@@H](Cc1csc2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCCc1cc(Br)c(Br)s1
Cl.NCc1nnc2c(=O)[nH]ccn12
O=C(N[Dy])[C@H](Cc1csc2ccccc12)Nc1nc(NCCc2cc(Br)c(Br)s2)nc(NCc2nnc3c(=O)[nH]ccn23)n1
sEH
1
46,714,902
Cc1c(Br)ccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNC2=O
NCc1nc2c(s1)CCCC2
Cc1c(Br)ccc(C(=O)N[Dy])c1Nc1nc(NCc2nc3c(s2)CCCC3)nc(Nc2ccc3c(c2)CNC3=O)n1
BRD4
1
74,500,263
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1ccnc(Cl)c1N
Nc1c(F)cccc1F
Cc1ccnc(Cl)c1Nc1nc(Nc2c(F)cccc2F)nc(NC(Cc2ccccc2)C(=O)N[Dy])n1
BRD4
1
229,288,734
O=C(Nc1ncc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc[n+]([O-])c1
NCc1cnns1
O=C(N[Dy])c1cc(Br)cnc1Nc1nc(NCc2ccc[n+]([O-])c2)nc(NCc2cnns2)n1
BRD4
1
27,189,459
COC(=O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1nc(Cl)ccc1Cl
Nc1ccc2c(c1)CNC2=O
COC(=O)CC(Nc1nc(Nc2ccc3c(c2)CNC3=O)nc(Nc2nc(Cl)ccc2Cl)n1)C(=O)N[Dy]
BRD4
1
277,138,580
O=C(O)C[C@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cc1ccnc(Cl)c1N
Cl.NCC1(O)C2C3CC4C5C3CC2C5C41
Cc1ccnc(Cl)c1Nc1nc(NCC2(O)C3C4CC5C6C4CC3C6C52)nc(N2Cc3ccccc3C[C@@H]2CC(=O)N[Dy])n1
sEH
1
89,826,533
O=C(N[C@@H](CCC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
NCCc1nccc(C2CC2)n1
O=C(N[Dy])[C@H](CCC1CCCCC1)Nc1nc(NCCc2nccc(C3CC3)n2)nc(NCc2ccc(O)c3ncccc23)n1
sEH
1
19,281,876
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCCC(O)C1CCCC1
CC(CCN)S(C)=O
CC(OC(C)(C)C)C(Nc1nc(NCCC(O)C2CCCC2)nc(NCCC(C)S(C)=O)n1)C(=O)N[Dy]
BRD4
1
147,570,517
O=C(Nc1c(Cl)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
CCOC(=O)c1cnn(C)c1N
CCOC(=O)c1cnn(C)c1Nc1nc(NCc2ccc(O)c3ncccc23)nc(Nc2c(Cl)cccc2C(=O)N[Dy])n1
HSA
1
82,620,467
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(F)cc1F
Cc1cccc(N)c1Cl
Cc1cccc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3ccc(F)cc3F)n2)c1Cl
sEH
1
169,108,809
O=C(Nc1cc(Cl)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cc(CN)c(Br)cn1
Cl.Cn1cc(N)ccc1=O
COc1cc(CNc2nc(Nc3ccc(=O)n(C)c3)nc(Nc3cc(Cl)ccc3C(=O)N[Dy])n2)c(Br)cn1
BRD4
1
51,646,009
Cc1cc(C)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
Cc1nccn1-c1ncccc1CN
COc1cncc(N)n1
COc1cncc(Nc2nc(NCc3cccnc3-n3ccnc3C)nc(Nc3c(C)cc(C)cc3C(=O)N[Dy])n2)n1
HSA
1
65,879,092
N#Cc1ccc(C[C@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Cl.Cl.NCc1cncc(F)c1
Nc1cc(F)c(F)cc1Br
N#Cc1ccc(C[C@H](CC(=O)N[Dy])Nc2nc(NCc3cncc(F)c3)nc(Nc3cc(F)c(F)cc3Br)n2)cc1
HSA
1
218,083,014
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1ccc(N)cc1OC
CC1(C)NC(=O)N(CCCN)C1=O.Cl
COC(=O)c1ccc(Nc2nc(NCCCN3C(=O)NC(C)(C)C3=O)nc(Nc3ccnc(C(=O)N[Dy])c3)n2)cc1OC
BRD4
1
174,250,802
O=C(Nc1cc(F)c(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cncc(F)c1
COC(=O)c1nc(N)sc1Br
COC(=O)c1nc(Nc2nc(Nc3cncc(F)c3)nc(Nc3cc(F)c(F)cc3C(=O)N[Dy])n2)sc1Br
sEH
1
234,095,775
O=C(O)C1CCN(C(=O)OCC2c3ccccc3-c3ccccc32)C1
Nc1ccc2[nH]ncc2c1
Cl.NCCS(=O)(=O)Nc1ccccc1
O=C(N[Dy])C1CCN(c2nc(NCCS(=O)(=O)Nc3ccccc3)nc(Nc3ccc4[nH]ncc4c3)n2)C1
BRD4
1
82,364,117
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnoc1C1CC1
CC(CN)Oc1ccc(Cl)cc1
CC(CNc1nc(NCc2cnoc2C2CC2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1)Oc1ccc(Cl)cc1
sEH
1
211,870,060
O=C(Nc1cccc(Cl)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Nc1ccncn1
O=C(N[Dy])c1c(Cl)cccc1Nc1nc(NCc2cncc(F)c2)nc(Nc2ccncn2)n1
HSA
1
285,346,204
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2cnccc12
Nc1cc(-c2ccccc2)[nH]n1
O=C(N[Dy])[C@@H]1Cc2ccc(O)cc2CN1c1nc(Nc2cc(-c3ccccc3)[nH]n2)nc(Nc2cccc3cnccc23)n1
HSA
1
83,472,254
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Nc1cc(O)ccn1
COc1ccc2nc(N)sc2c1
COc1ccc2nc(Nc3nc(NC[C@H]4CC[C@H](C(=O)N[Dy])CC4)nc(Nc4cc(O)ccn4)n3)sc2c1
sEH
1
285,951,968
O=C(O)[C@@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Nc1n[nH]c2c(Cl)cc([N+](=O)[O-])cc12
O=C(N[Dy])[C@@H]1Cc2ccccc2CN1c1nc(NCc2cncc(F)c2)nc(Nc2n[nH]c3c(Cl)cc([N+](=O)[O-])cc23)n1
sEH
1
112,721,619
O=C(N[C@H](C(=O)O)C1CCCC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cnsc1
Nc1ccc2c(c1)CNC2=O
O=C1NCc2cc(Nc3nc(NCc4cnsc4)nc(N[C@H](C(=O)N[Dy])C4CCCC4)n3)ccc21
BRD4
1
128,594,540
O=C(N[C@H]1C=C[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
CC(C)(CN)CCC#N
Cl.NCC1CC(=O)N(Cc2ccccc2)C1
CC(C)(CCC#N)CNc1nc(NCC2CC(=O)N(Cc3ccccc3)C2)nc(N[C@H]2C=C[C@@H](C(=O)N[Dy])C2)n1
sEH
1
14,058,402
CC(C)(C)OC(=O)CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cccc2[nH]ccc12
COCc1ccccc1CN
COCc1ccccc1CNc1nc(Nc2cccc3[nH]ccc23)nc(NC(CCC(=O)OC(C)(C)C)C(=O)N[Dy])n1
BRD4
1
152,336,051
O=C(Nc1c(F)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
Cl.Cl.NCc1ccc2scnc2c1
O=C(N[Dy])c1cccc(F)c1Nc1nc(NCc2ccc3scnc3c2)nc(Nc2ccc(Cn3ccnc3)cc2)n1
sEH
1
184,235,615
O=C(Nc1ccc(C(=O)O)c(Cl)c1)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1ncccc1N
COc1ccc2nnc(CN)n2n1
CCOC(=O)c1ncccc1Nc1nc(NCc2nnc3ccc(OC)nn23)nc(Nc2ccc(C(=O)N[Dy])c(Cl)c2)n1
sEH
1
179,780,655
O=C(Nc1ccc(Br)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
C=CCSCCN
Cl.Cn1cc(N)ccc1=O
C=CCSCCNc1nc(Nc2ccc(Br)c(C(=O)N[Dy])c2)nc(Nc2ccc(=O)n(C)c2)n1
BRD4
1
16,966,528
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.NCCc1c[nH]c2cc(Cl)ccc12
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCCc4c[nH]c5cc(Cl)ccc45)nc(NC(COC(C)(C)C)C(=O)N[Dy])n3)ccc2[nH]1
HSA
1
258,089,847
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Cl)cc1
Nc1cccc(-n2cncn2)c1
CNC(=O)c1ccc(N)cc1F
CNC(=O)c1ccc(Nc2nc(Nc3cccc(-n4cncn4)c3)nc(N[C@H](CC(=O)N[Dy])c3ccc(Cl)cc3)n2)cc1F
BRD4
1
82,965,614
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(Cl)ccc1N
Br.Br.NCC1CCCN1c1cccnn1
COC(=O)c1cc(Cl)ccc1Nc1nc(NCC2CCCN2c2cccnn2)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
51,714,620
Cc1cc(C)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
Cl.Cl.NCc1cncc(F)c1
Nc1ncnc2[nH]ncc12
Cc1cc(C)c(Nc2nc(NCc3cncc(F)c3)nc(Nc3ncnc4[nH]ncc34)n2)c(C(=O)N[Dy])c1
sEH
1
282,032,293
O=C(O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2[nH]ncc2c1
Cl.NCc1nnc2ncccn12
O=C(N[Dy])[C@@H]1CCCN1C(=O)[C@@H]1CCCN1c1nc(NCc2nnc3ncccn23)nc(Nc2ccc3[nH]ncc3c2)n1
HSA
1
16,789,908
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cc1nnc(N)s1
NCc1cc2c(s1)CCSC2
Cc1nnc(Nc2nc(NCc3cc4c(s3)CCSC4)nc(NC(COC(C)(C)C)C(=O)N[Dy])n2)s1
BRD4
1
82,858,577
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(F)(F)CN.Cl
Cc1sc(N)c(C#N)c1C
Cc1sc(Nc2nc(NCC(C)(F)F)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)c(C#N)c1C
sEH
1
284,861,720
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
NCc1cn2cccc(F)c2n1
O=C(N[Dy])[C@@H]1Cc2ccc(O)cc2CN1c1nc(NCc2cncc(F)c2)nc(NCc2cn3cccc(F)c3n2)n1
sEH
1
106,665,853
O=C(N[C@@H](Cc1cccs1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2cnccc12
Cn1ccc(S(=O)(=O)NCCN)c1
Cn1ccc(S(=O)(=O)NCCNc2nc(Nc3cccc4cnccc34)nc(N[C@@H](Cc3cccs3)C(=O)N[Dy])n2)c1
HSA
1
14,307,037
CC(C)(C)OC(=O)N1CCN(C(=O)OCC2c3ccccc3-c3ccccc32)C1C(=O)O
CN1C(=O)Cc2cc(CN)ccc21.Cl
CCOC(=O)c1coc(N)n1
CCOC(=O)c1coc(Nc2nc(NCc3ccc4c(c3)CC(=O)N4C)nc(N3CCN(C(=O)OC(C)(C)C)C3C(=O)N[Dy])n2)n1
HSA
1
103,993,288
O=C(N[C@@H](Cc1cccnc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
NCc1cn2cc(Cl)ccc2n1
O=C(N[Dy])[C@H](Cc1cccnc1)Nc1nc(NCc2cn3cc(Cl)ccc3n2)nc(NCc2ccc(O)c3ncccc23)n1
HSA
1
116,240,342
O=C(N[C@H](CC1CCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
CCSc1ccc(CN)cc1
CCSc1ccc(CNc2nc(NCCC3CSC3)nc(N[C@H](CC3CCCC3)C(=O)N[Dy])n2)cc1
sEH
1
235,017,661
O=C(O)C1CN(C(=O)OCC2c3ccccc3-c3ccccc32)C1
NCCN1CC[C@@H](O)C1
Nc1cc(C2CC2)[nH]n1
O=C(N[Dy])C1CN(c2nc(NCCN3CC[C@@H](O)C3)nc(Nc3cc(C4CC4)[nH]n3)n2)C1
HSA
1
33,585,350
COc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)cc1OC
Nc1ccc(Cn2ccnc2)cc1
Cc1ccncc1N
COc1cc(Nc2nc(Nc3ccc(Cn4ccnc4)cc3)nc(Nc3cnccc3C)n2)c(C(=O)N[Dy])cc1OC
sEH
1
18,123,349
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cn1cncc1C(CN)N1CCCC1
Nc1ccc2c(c1)CC(=O)N2
CC(C)CC(Nc1nc(NCC(c2cncn2C)N2CCCC2)nc(Nc2ccc3c(c2)CC(=O)N3)n1)C(=O)N[Dy]
HSA
1
63,697,991
N#Cc1ccc(C[C@@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Cl.Cl.NCc1cncc(F)c1
CC(CN)Cn1cccn1
CC(CNc1nc(NCc2cncc(F)c2)nc(N[C@H](CC(=O)N[Dy])Cc2ccc(C#N)cc2)n1)Cn1cccn1
sEH
1
82,778,213
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ncccc1CO
NCc1nc2ccccc2s1
O=C(N[Dy])C1CCC(CNc2nc(NCc3nc4ccccc4s3)nc(Nc3ncccc3CO)n2)CC1
sEH
1
82,613,453
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(F)c(Cl)c1F
CC1(C)CC(CCN)C(=O)N1.Cl
CC1(C)CC(CCNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3ccc(F)c(Cl)c3F)n2)C(=O)N1
sEH
1