id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
258,896,700
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc(Cl)c1
Cn1ncc2cc(N)ccc21
NCc1cnc(-c2ccccc2)s1
Cn1ncc2cc(Nc3nc(NCc4cnc(-c5ccccc5)s4)nc(N[C@H](CC(=O)N[Dy])c4cccc(Cl)c4)n3)ccc21
BRD4
1
123,189,062
O=C(N[C@H](Cc1ccc(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CC1CN(S(=O)(=O)CCN)CC(C)O1
C=CCSCCN
C=CCSCCNc1nc(NCCS(=O)(=O)N2CC(C)OC(C)C2)nc(N[C@H](Cc2ccc(F)c(F)c2)C(=O)N[Dy])n1
sEH
1
81,984,818
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1ccc([N+](=O)[O-])c(N)n1
Cn1nnc(N)n1
COc1ccc([N+](=O)[O-])c(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3nnn(C)n3)n2)n1
sEH
1
55,551,666
Cc1ccc(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1nccnc1Cl
Cl.Cn1cc(N)ccc1=O
Cc1ccc(C(=O)N[Dy])cc1Nc1nc(Nc2ccc(=O)n(C)c2)nc(Nc2nccnc2Cl)n1
BRD4
1
104,334,529
O=C(N[C@@H](Cc1cccnc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1c(F)cccc1F
Nc1ncnc2[nH]ncc12
O=C(N[Dy])[C@H](Cc1cccnc1)Nc1nc(Nc2c(F)cccc2F)nc(Nc2ncnc3[nH]ncc23)n1
HSA
1
82,192,985
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCCn1cnc2ccsc2c1=O
Cc1nc(N)ccc1Cl
Cc1nc(Nc2nc(NCCn3cnc4ccsc4c3=O)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)ccc1Cl
sEH
1
131,289,842
O=C(N[C@H]1CC[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
Cl.NCC12CC3CC(CC(C3)C1)C2
Nc1ccc2nccnc2c1Br
O=C(N[Dy])[C@@H]1CC[C@H](Nc2nc(NCC34CC5CC(CC(C5)C3)C4)nc(Nc3ccc4nccnc4c3Br)n2)C1
sEH
1
81,847,637
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CN(C)c1nc(Cl)c(CN)s1.Cl.Cl
Cl.NCCNC(N)=O
CN(C)c1nc(Cl)c(CNc2nc(NCCNC(N)=O)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)s1
sEH
1
166,802,672
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1ncccc1N
Nc1ncnc(=O)[nH]1
CCOC(=O)c1ncccc1Nc1nc(Nc2ncnc(=O)[nH]2)nc(Nc2cc(C(=O)N[Dy])ccc2Cl)n1
sEH
1
285,859,742
O=C(O)[C@@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cc1ccncc1N
N#Cc1c[nH]nc1N
Cc1ccncc1Nc1nc(Nc2n[nH]cc2C#N)nc(N2Cc3ccccc3C[C@H]2C(=O)N[Dy])n1
sEH
1
91,887,125
O=C(N[C@@H](Cc1cc(F)c(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)nnc1Cl
NCC1CN2CCN1CC2
Cc1cc(Nc2nc(NCC3CN4CCN3CC4)nc(N[C@@H](Cc3cc(F)c(F)c(F)c3)C(=O)N[Dy])n2)nnc1Cl
sEH
1
1,365,427
C#CC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COc1ccc(O)c(N)c1
N#Cc1nc[nH]c1N
C#CC[C@@H](Nc1nc(Nc2cc(OC)ccc2O)nc(Nc2[nH]cnc2C#N)n1)C(=O)N[Dy]
HSA
1
188,044,485
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc(Cl)s1
CCSc1ccc(CN)cc1
CCSc1ccc(CNc2nc(NCc3cnc(Cl)s3)nc(Nc3ccc(C(=O)N[Dy])cc3)n2)cc1
BRD4
1
267,794,340
O=C(O)C[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
COc1ccc([N+](=O)[O-])c(N)n1
COc1ccc([N+](=O)[O-])c(Nc2nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])nc(N[C@H](CC(=O)N[Dy])Cc3ccc(Cl)c(Cl)c3)n2)n1
BRD4
1
81,966,692
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1ccc(CN)c(C)c1OC
NCC(O)c1ccc(Cl)s1.O=C(O)C(F)(F)F
COc1ccc(CNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NCC(O)c3ccc(Cl)s3)n2)c(C)c1OC
sEH
1
243,726,140
O=C(O)C[C@@H](Cc1ccc(Br)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
NCCN1CCC2(C1)OCCO2
Nc1ccc(Cl)c(C(F)(F)F)c1
O=C(C[C@@H](Cc1ccc(Br)cc1)Nc1nc(NCCN2CCC3(C2)OCCO3)nc(Nc2ccc(Cl)c(C(F)(F)F)c2)n1)N[Dy]
sEH
1
200,633,613
O=C(Nc1ccc(F)c(C(=O)O)c1F)OCC1c2ccccc2-c2ccccc21
CNC(=O)c1ccc(N)cc1F
Cn1nccc1[C@@H]1OCC[C@H]1CN
CNC(=O)c1ccc(Nc2nc(NC[C@@H]3CCO[C@H]3c3ccnn3C)nc(Nc3ccc(F)c(C(=O)N[Dy])c3F)n2)cc1F
BRD4
1
280,650,085
O=C(O)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Nc1nccc2cccnc12
O=C(N[Dy])[C@@H]1CCCN1c1nc(NCc2cnc3n2CCOC3)nc(Nc2nccc3cccnc23)n1
HSA
1
174,103,380
O=C(Nc1cc(F)c(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Cn1cc(C(F)F)c(CN)n1
Cn1cc(C(F)F)c(CNc2nc(Nc3cc(F)c(F)cc3C(=O)N[Dy])nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])n2)n1
BRD4
1
188,343,914
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)C(O)CCC2
Nc1cc2cccnc2c2ncccc12
O=C(N[Dy])c1ccc(Nc2nc(Nc3ccc4c(c3)C(O)CCC4)nc(Nc3cc4cccnc4c4ncccc34)n2)cc1
sEH
1
51,183,964
Cc1cc(C(=O)O)ccc1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1nccc2cccnc12
Nc1ccc(F)cc1Cl
Cc1cc(C(=O)N[Dy])ccc1Nc1nc(Nc2ccc(F)cc2Cl)nc(Nc2nccc3cccnc23)n1
HSA
1
264,413,489
O=C(O)C[C@H](Cc1c(F)c(F)c(F)c(F)c1F)NC(=O)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
COc1ccc(Cl)c(N)c1.Cl
COc1ccc(Cl)c(Nc2nc(NCCC3CSC3)nc(N[C@H](CC(=O)N[Dy])Cc3c(F)c(F)c(F)c(F)c3F)n2)c1
sEH
1
81,850,823
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CN(CC(F)(F)F)C(=O)CN.Cl
COc1ccc([N+](=O)[O-])c(N)n1
COc1ccc([N+](=O)[O-])c(Nc2nc(NCC(=O)N(C)CC(F)(F)F)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)n1
sEH
1
202,051,322
O=C(Nc1ccc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
NCc1ccc(CN2CCCC2=O)cc1
O=C(N[Dy])c1cc(F)ccc1Nc1nc(NCc2ccc(CN3CCCC3=O)cc2)nc(NCc2ccc(O)c3ncccc23)n1
sEH
1
106,162,207
O=C(N[C@@H](Cc1cccs1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NC[C@@H]1CCO[C@H]1c1cn[nH]c1
Nc1nc[nH]n1
O=C(N[Dy])[C@H](Cc1cccs1)Nc1nc(NC[C@@H]2CCO[C@H]2c2cn[nH]c2)nc(Nc2nc[nH]n2)n1
HSA
1
72,061,774
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CN1CCN(CCN)CC1
Nc1cc[nH]n1
CN1CCN(CCNc2nc(Nc3cc[nH]n3)nc(NC(CC3CCCCC3)C(=O)N[Dy])n2)CC1
HSA
1
75,142,881
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ncc(F)cc1[N+](=O)[O-]
CN1CC(CCN)CC1=O
CN1CC(CCNc2nc(Nc3ncc(F)cc3[N+](=O)[O-])nc(NC(Cc3ccccc3)C(=O)N[Dy])n2)CC1=O
BRD4
1
192,400,781
O=C(Nc1ccc(C(=O)O)cc1O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1ccnc(C(N)=O)c1
CC1CCc2nc(CN)sc2C1
CC1CCc2nc(CNc3nc(NCc4ccnc(C(N)=O)c4)nc(Nc4ccc(C(=O)N[Dy])cc4O)n3)sc2C1
sEH
1
81,748,049
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(C)(CN)C(=O)N1CCCC1
Cl.NCc1ccc(-c2nnn[nH]2)cc1
CC(C)(CNc1nc(NCc2ccc(-c3nnn[nH]3)cc2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1)C(=O)N1CCCC1
sEH
1
146,886,710
O=C(Nc1c(Cl)cc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
CC(CN)c1nccs1
CC(CNc1nc(Nc2ccc(Cn3ccnc3)cc2)nc(Nc2c(Cl)cc(F)cc2C(=O)N[Dy])n1)c1nccs1
sEH
1
123,144,860
O=C(N[C@H](Cc1ccc(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CC(C)(CN)CCC#N
CC1CN(S(=O)(=O)CCN)CC(C)O1
CC1CN(S(=O)(=O)CCNc2nc(NCC(C)(C)CCC#N)nc(N[C@H](Cc3ccc(F)c(F)c3)C(=O)N[Dy])n2)CC(C)O1
sEH
1
64,516,089
N#Cc1ccc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
COc1c(N)cccc1F
NCc1cccs1
COc1c(F)cccc1Nc1nc(NCc2cccs2)nc(N[C@H](Cc2ccc(C#N)cc2)C(=O)N[Dy])n1
BRD4
1
17,441,359
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
C=C(Cl)CN.Cl
Nc1nnn[nH]1
C=C(Cl)CNc1nc(Nc2nnn[nH]2)nc(NC(CC(C)C)C(=O)N[Dy])n1
HSA
1
61,228,647
Cc1ccccc1[C@@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
COC1(OC)CC(CN)C1
COC(=O)c1ccc(N)cc1C
COC(=O)c1ccc(Nc2nc(NCC3CC(OC)(OC)C3)nc(N[C@H](CC(=O)N[Dy])c3ccccc3C)n2)cc1C
BRD4
1
238,224,254
O=C(O)CC1(CNC(=O)OCC2c3ccccc3-c3ccccc32)CCCCC1
N#Cc1ncc(N)cc1C(F)(F)F
Cl.NCC1(O)C2C3CC4C5C3CC2C5C41
N#Cc1ncc(Nc2nc(NCC3(CC(=O)N[Dy])CCCCC3)nc(NCC3(O)C4C5CC6C7C5CC4C7C63)n2)cc1C(F)(F)F
sEH
1
218,760,051
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)ncn1
Cn1cc(N)cn1
Cn1cc(Nc2nc(Nc3ccnc(C(=O)N[Dy])c3)nc(Nc3cc(Cl)ncn3)n2)cn1
BRD4
1
129,946,639
O=C(N[C@H]1CCC[C@@H]1C(=O)O)OCC1c2ccccc2-c2ccccc21
CS(=O)(=O)CC1(CN)CCOCC1.Cl
Cl.Cl.NCc1nc2c(s1)CCC2
CS(=O)(=O)CC1(CNc2nc(NCc3nc4c(s3)CCC4)nc(N[C@H]3CCC[C@@H]3C(=O)N[Dy])n2)CCOCC1
HSA
1
71,910,031
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
C#Cc1ccc(N)cc1
NCc1cc2c(s1)CCSC2
C#Cc1ccc(Nc2nc(NCc3cc4c(s3)CCSC4)nc(NC(CC3CCCCC3)C(=O)N[Dy])n2)cc1
HSA
1
206,383,690
O=C(Nc1ccc2cc(C(=O)O)ccc2c1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC=Cc1cccnc1
COc1ccc(N)nc1
COc1ccc(Nc2nc(NCC=Cc3cccnc3)nc(Nc3ccc4cc(C(=O)N[Dy])ccc4c3)n2)nc1
HSA
1
74,975,338
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(C(=O)N2CCOCC2)cc1
CCOC(=O)c1nonc1N
CCOC(=O)c1nonc1Nc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2)nc(NC(Cc2ccccc2)C(=O)N[Dy])n1
HSA
1
218,465,811
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CCCC1
Cl.NCCn1cnc2sccc2c1=O
O=C(N[Dy])c1cc(Nc2nc(NCCn3cnc4sccc4c3=O)nc(NCC3CCCC3)n2)ccn1
BRD4
1
122,907,915
O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cl)c(C(F)(F)F)c1
Cl.Cl.NCC(O)c1ccncc1
O=C(N[Dy])[C@@H](Cc1ccc(Cl)cc1)Nc1nc(NCC(O)c2ccncc2)nc(Nc2ccc(Cl)c(C(F)(F)F)c2)n1
BRD4
1
17,214,329
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cc(F)ccn1
Cl.NCC12CC3CC(CC(C3)C1)C2
CC(C)(C)OCC(Nc1nc(NCC23CC4CC(CC(C4)C2)C3)nc(Nc2cc(F)ccn2)n1)C(=O)N[Dy]
sEH
1
273,785,980
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(F)cc1
Cc1c(Br)cncc1CN.Cl.Cl
Cl.Cl.Cn1cncc1CN
Cc1c(Br)cncc1CNc1nc(NCc2cncn2C)nc(N[C@@H](CC(=O)N[Dy])c2ccc(F)cc2)n1
HSA
1
270,684,755
O=C(O)C[C@H](Cc1ccc(I)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Nc1nc(OCc2ccccc2)c2nc[nH]c2n1
O=C(C[C@H](Cc1ccc(I)cc1)Nc1nc(NCc2ccc(O)c3ncccc23)nc(Nc2nc(OCc3ccccc3)c3nc[nH]c3n2)n1)N[Dy]
sEH
1
278,468,758
O=C(O)Cc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Cl.NCc1cnc2n1CCOC2
COC(=O)c1cncc(N)c1
COC(=O)c1cncc(Nc2nc(NCc3cnc4n3CCOC4)nc(Nc3ccc(CC(=O)N[Dy])cc3)n2)c1
HSA
1
191,156,387
O=C(Nc1ccc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
CCOC(=O)c1cc(N)[nH]n1
CCOC(=O)c1cc(Nc2nc(NCc3ccc(O)c4ncccc34)nc(Nc3ccc(C(=O)N[Dy])cc3F)n2)[nH]n1
sEH
1
209,835,763
O=C(Nc1cccc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
COc1ccc(CN)cc1CN1CCOCC1.Cl.Cl
COc1ccc(CNc2nc(NCc3cnc4n3CCOC4)nc(Nc3cccc(C(=O)N[Dy])c3)n2)cc1CN1CCOCC1
HSA
1
210,360,303
O=C(Nc1cccc(C(=O)O)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCC#CCN
NCc1ccc(CN2CCCC2=O)cc1
CCC#CCNc1nc(NCc2ccc(CN3CCCC3=O)cc2)nc(Nc2cccc(C(=O)N[Dy])c2C(=O)O)n1
BRD4
1
123,228,870
O=C(N[C@H](Cc1ccc(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CCOc1cc(N)ccn1
Cc1cc(CN)c(C)s1
CCOc1cc(Nc2nc(NCc3cc(C)sc3C)nc(N[C@H](Cc3ccc(F)c(F)c3)C(=O)N[Dy])n2)ccn1
BRD4
1
83,546,078
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCC1CCC(C(F)F)CC1
CC(C)c1nc(N)sc1Br
CC(C)c1nc(Nc2nc(NCC3CCC(C(F)F)CC3)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)sc1Br
sEH
1
246,839,708
O=C(O)C[C@@H](Cc1ccc(Cl)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCCS(=O)(=O)c1ccc(Cl)cc1
CS(=O)(=O)Nc1ccc(-c2csc(N)n2)cc1
CS(=O)(=O)Nc1ccc(-c2csc(Nc3nc(NCCS(=O)(=O)c4ccc(Cl)cc4)nc(N[C@@H](CC(=O)N[Dy])Cc4ccc(Cl)cc4)n3)n2)cc1
sEH
1
29,923,453
COc1cc(C(=O)O)c(N)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
NCCN1CC[C@@H](O)C1
COc1cc(C(=O)N[Dy])c(N)cc1Nc1nc(NCCN2CC[C@@H](O)C2)nc(NCc2cncc(F)c2)n1
HSA
1
32,076,652
COc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c(OC)c1
Cl.Cl.NCCn1cccnc1=O
COC(=O)c1sccc1N
COC(=O)c1sccc1Nc1nc(NCCn2cccnc2=O)nc(Nc2cc(OC)cc(OC)c2C(=O)N[Dy])n1
HSA
1
270,945,289
O=C(O)C[C@H](Cc1ccc(I)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
NCC1CN2CCN1CC2
Nc1n[nH]c2ncccc12
O=C(C[C@H](Cc1ccc(I)cc1)Nc1nc(NCC2CN3CCN2CC3)nc(Nc2n[nH]c3ncccc23)n1)N[Dy]
HSA
1
228,838,659
O=C(Nc1ncc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CC(C)c1nnc([C@H]2C[C@H](CN)[C@H](O)C2)[nH]1
Nc1ncccc1C=O
CC(C)c1nnc([C@H]2C[C@H](CNc3nc(Nc4ncccc4C=O)nc(Nc4ncc(Br)cc4C(=O)N[Dy])n3)[C@H](O)C2)[nH]1
BRD4
1
273,450,919
O=C(O)C[C@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1nnc(S)s1
Nc1nc2cc(Br)ccn2n1
O=C(C[C@H](Cc1cccs1)Nc1nc(Nc2nc3cc(Br)ccn3n2)nc(Nc2nnc(S)s2)n1)N[Dy]
HSA
1
111,651,297
O=C(N[C@H](C(=O)O)C1CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cn1cc(CN)c(Br)n1
Cl.Cn1cc(N)ccc1=O
Cn1cc(CNc2nc(Nc3ccc(=O)n(C)c3)nc(N[C@H](C(=O)N[Dy])C3CC3)n2)c(Br)n1
BRD4
1
82,842,320
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(C)Cn1cnc2c(N)nc3ccccc3c21
NCc1cnns1
CC(C)Cn1cnc2c(Nc3nc(NCc4cnns4)nc(NC[C@H]4CC[C@H](C(=O)N[Dy])CC4)n3)nc3ccccc3c21
sEH
1
217,196,673
O=C(Nc1cccnc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1ccc(C#N)cc1N
NCCS(=O)Cc1ccccc1
Cc1ccc(C#N)cc1Nc1nc(NCCS(=O)Cc2ccccc2)nc(Nc2cccnc2C(=O)N[Dy])n1
BRD4
1
41,869,546
CS(=O)(=O)c1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1
Cl.Cl.NCC=Cc1cccnc1
COC(=O)c1cscc1N.Cl
COC(=O)c1cscc1Nc1nc(NCC=Cc2cccnc2)nc(Nc2cc(S(C)(=O)=O)ccc2C(=O)N[Dy])n1
HSA
1
270,829,831
O=C(O)C[C@H](Cc1ccc(I)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cc(F)c(Cl)cc1F
Nc1cc(Cl)nc(Cl)c1[N+](=O)[O-]
O=C(C[C@H](Cc1ccc(I)cc1)Nc1nc(NCc2cc(F)c(Cl)cc2F)nc(Nc2cc(Cl)nc(Cl)c2[N+](=O)[O-])n1)N[Dy]
HSA
1
65,202,416
N#Cc1ccc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Nc1ccc(N2CCC=C(N3CCOCC3)C2=O)cc1
NCc1cn2cc(Cl)ccc2n1
N#Cc1ccc(C[C@@H](Nc2nc(NCc3cn4cc(Cl)ccc4n3)nc(Nc3ccc(N4CCC=C(N5CCOCC5)C4=O)cc3)n2)C(=O)N[Dy])cc1
sEH
1
82,331,459
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCCS(=O)(=O)c1ccc(Cl)cc1
Nc1ccc(N2CCC(N3CCOCC3)CC2)cc1
O=C(N[Dy])C1CCC(CNc2nc(NCCS(=O)(=O)c3ccc(Cl)cc3)nc(Nc3ccc(N4CCC(N5CCOCC5)CC4)cc3)n2)CC1
sEH
1
285,261,618
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(F)c([N+](=O)[O-])c1
Cl.Cn1cc(N)ccc1=O
Cn1cc(Nc2nc(Nc3ccc(F)c([N+](=O)[O-])c3)nc(N3Cc4cc(O)ccc4C[C@H]3C(=O)N[Dy])n2)ccc1=O
BRD4
1
82,757,783
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ncc(Cl)c(Cl)n1
CCSC1CCC1(O)CN
CCSC1CCC1(O)CNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2ncc(Cl)c(Cl)n2)n1
sEH
1
118,532,475
O=C(N[C@H](Cc1cc(F)cc(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Nc1cc(Cl)nnc1Cl
O=C(N[Dy])[C@@H](Cc1cc(F)cc(F)c1)Nc1nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])nc(Nc2cc(Cl)nnc2Cl)n1
BRD4
1
187,648,026
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
COc1ccc(CN)c(C)c1OC
C=CCOCCCN
C=CCOCCCNc1nc(NCc2ccc(OC)c(OC)c2C)nc(Nc2ccc(C(=O)N[Dy])cc2)n1
BRD4
1
84,438,059
O=C(NCc1cccc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.NCC1(O)C2C3CC4C5C3CC2C5C41
Nc1c(F)cccc1F
O=C(N[Dy])c1cccc(CNc2nc(NCC3(O)C4C5CC6C7C5CC4C7C63)nc(Nc3c(F)cccc3F)n2)c1
sEH
1
246,224,366
O=C(O)C[C@@H](Cc1ccc(Cl)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
C=C(C)COCCN.Cl
Cc1cc2cc(CN)ccc2[nH]1
C=C(C)COCCNc1nc(NCc2ccc3[nH]c(C)cc3c2)nc(N[C@@H](CC(=O)N[Dy])Cc2ccc(Cl)cc2)n1
sEH
1
128,932,234
O=C(N[C@H]1C=C[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)on1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc(Nc2nc(NCc3ccc4[nH]c(C)cc4c3)nc(N[C@H]3C=C[C@@H](C(=O)N[Dy])C3)n2)on1
HSA
1
18,756,132
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COc1c(N)cccc1F
NCc1cc2c(s1)CCSC2
COc1c(F)cccc1Nc1nc(NCc2cc3c(s2)CCSC3)nc(NC(C(=O)N[Dy])C(C)OC(C)(C)C)n1
BRD4
1
81,959,453
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1cc(N)ccn1
Cn1cc(C2(CN)CCCO2)cn1
COc1cc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NCC3(c4cnn(C)c4)CCCO3)n2)ccn1
sEH
1
19,295,910
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCCN1CC2CCC1C2
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
CC(OC(C)(C)C)C(Nc1nc(NCCN2CC3CCC2C3)nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])n1)C(=O)N[Dy]
BRD4
1
191,683,621
O=C(Nc1ccc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
Nc1cncc(Cl)n1
Cl.Cl.NCc1ccc(O)c2ncccc12
O=C(N[Dy])c1ccc(Nc2nc(NCc3ccc(O)c4ncccc34)nc(Nc3cncc(Cl)n3)n2)c(F)c1
HSA
1
8,502,384
C=CCC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Cc1c(N)cccc1F
C=CCC[C@@H](Nc1nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])nc(Nc2cccc(F)c2C)n1)C(=O)N[Dy]
BRD4
1
7,016,281
C=CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Cl.NCCc1nc2c(s1)COCC2
Cl.Cl.NCc1cncc(F)c1
C=CCC(Nc1nc(NCCc2nc3c(s2)COCC3)nc(NCc2cncc(F)c2)n1)C(=O)N[Dy]
HSA
1
82,212,125
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cn2cc(Br)ccc2n1
COC(=O)c1nc(N)sc1Br
COC(=O)c1nc(Nc2nc(NCc3cn4cc(Br)ccc4n3)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)sc1Br
sEH
1
116,816,760
O=C(N[C@H](CCC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cc(N)ccn1
NCc1ccc2[nH]ccc2c1
COc1cc(Nc2nc(NCc3ccc4[nH]ccc4c3)nc(N[C@H](CCC3CCCCC3)C(=O)N[Dy])n2)ccn1
BRD4
1
70,236,274
N#Cc1cccc(C[C@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)c1
Cl.Cl.NCc1cncc(F)c1
CNC(=O)c1cc(Oc2ccc(N)cc2)ccn1
CNC(=O)c1cc(Oc2ccc(Nc3nc(NCc4cncc(F)c4)nc(N[C@@H](CC(=O)N[Dy])Cc4cccc(C#N)c4)n3)cc2)ccn1
HSA
1
82,507,379
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1c[nH]c2ccccc12
Nc1ncc(Cl)nc1Cl
O=C(N[Dy])C1CCC(CNc2nc(NCc3c[nH]c4ccccc34)nc(Nc3ncc(Cl)nc3Cl)n2)CC1
sEH
1
96,365,923
O=C(N[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Nc1ncc(-c2ccccc2)s1
O=C(N[Dy])[C@H](Cc1ccc(Cl)cc1Cl)Nc1nc(NCc2ccc(O)c3ncccc23)nc(Nc2ncc(-c3ccccc3)s2)n1
HSA
1
83,447,954
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1ccsc1C(F)(F)F
Cc1n[nH]c(N)c1C
Cc1n[nH]c(Nc2nc(NCc3ccsc3C(F)(F)F)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)c1C
sEH
1
288,418,421
O=C(O)[C@H]1CC2CCCCC2N1C(=O)OCC1c2ccccc2-c2ccccc21
NCc1c(F)cccc1N1CCCC1
Cl.Cl.N=C(N)CCCN
N=C(CCCN)Nc1nc(NCc2c(F)cccc2N2CCCC2)nc(N2C3CCCCC3C[C@@H]2C(=O)N[Dy])n1
sEH
1
82,190,819
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCCn1cc(C2CC2)nn1
Nc1cn2nc(Cl)ccc2n1
O=C(N[Dy])C1CCC(CNc2nc(NCCn3cc(C4CC4)nn3)nc(Nc3cn4nc(Cl)ccc4n3)n2)CC1
sEH
1
90,182,679
O=C(N[C@@H](CCC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)c(O)c(Cl)c1
NCC(O)c1ccc(Cl)s1.O=C(O)C(F)(F)F
O=C(N[Dy])[C@H](CCC1CCCCC1)Nc1nc(NCC(O)c2ccc(Cl)s2)nc(Nc2cc(Cl)c(O)c(Cl)c2)n1
BRD4
1
47,292,504
Cc1cc(Br)c(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1nnc(CCCN)s1.Cl
COc1nc(Br)ccc1N
COc1nc(Br)ccc1Nc1nc(NCCCc2nnc(C)s2)nc(Nc2cc(C(=O)N[Dy])c(Br)cc2C)n1
BRD4
1
82,549,361
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1c2ccccc2nc2ccccc12
N#CC1=C(N)CCC1
N#CC1=C(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3c4ccccc4nc4ccccc34)n2)CCC1
sEH
1
160,150,867
O=C(Nc1cc(Br)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
C#CCOc1cccc(CN)c1.Cl
Cl.NCCN1C(=O)SC(=Cc2cccs2)C1=O
C#CCOc1cccc(CNc2nc(NCCN3C(=O)SC(=Cc4cccs4)C3=O)nc(Nc3cc(Br)ccc3C(=O)N[Dy])n2)c1
HSA
1
186,395,790
O=C(Nc1ccc(C(=O)O)c([N+](=O)[O-])c1)OCC1c2ccccc2-c2ccccc21
CCC(CN)Oc1ccccc1C.Cl
Nc1cc(Cl)c(O)c(Cl)c1
CCC(CNc1nc(Nc2cc(Cl)c(O)c(Cl)c2)nc(Nc2ccc(C(=O)N[Dy])c([N+](=O)[O-])c2)n1)Oc1ccccc1C
BRD4
1
73,503,827
O=C(NC(CCc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
CN(C)C1(CN)CCSC1
CN(C)C1(CNc2nc(NCc3cncc(F)c3)nc(NC(CCc3ccccc3)C(=O)N[Dy])n2)CCSC1
sEH
1
180,778,789
O=C(Nc1ccc(Br)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1cn[nH]c1
NCc1cn2cc(Cl)ccc2n1
O=C(N[Dy])c1cc(Nc2nc(NCc3cn4cc(Cl)ccc4n3)nc(Nc3cn[nH]c3)n2)ccc1Br
HSA
1
83,872,502
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ncco1
Cl.NCC(F)(F)C(N)=O
NC(=O)C(F)(F)CNc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2ncco2)n1
sEH
1
60,575,978
Cc1cccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c1C(=O)O
Cl.NCc1cnc2n1CCOC2
COC(=O)c1cncc(N)c1
COC(=O)c1cncc(Nc2nc(NCc3cnc4n3CCOC4)nc(Nc3cccc(C)c3C(=O)N[Dy])n2)c1
sEH
1
217,015,429
O=C(Nc1cccnc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(CN)C1CCCOC1
Cc1cc2cc(CN)ccc2[nH]1
COC(CNc1nc(NCc2ccc3[nH]c(C)cc3c2)nc(Nc2cccnc2C(=O)N[Dy])n1)C1CCCOC1
HSA
1
83,608,073
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1cccc(C(F)(F)F)n1
Nc1nc(-c2ccccc2Cl)cs1
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NCc3cccc(C(F)(F)F)n3)nc(Nc3nc(-c4ccccc4Cl)cs3)n2)CC1
sEH
1
28,192,797
COC(=O)c1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1
Nc1ccc2c(c1)CNC2=O
Cc1ccc(CN)c(OC2CCOC2)c1
COC(=O)c1ccc(C(=O)N[Dy])c(Nc2nc(NCc3ccc(C)cc3OC3CCOC3)nc(Nc3ccc4c(c3)CNC4=O)n2)c1
BRD4
1
119,891,540
O=C(N[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CC(CN)S(=O)(=O)N1CCN(c2ccccc2)CC1.Cl.Cl
NCc1cc(F)cc(F)c1
CC(CNc1nc(NCc2cc(F)cc(F)c2)nc(N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[Dy])n1)S(=O)(=O)N1CCN(c2ccccc2)CC1
sEH
1
53,924,062
Cc1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1C
Cl.NC1CCC(=O)CC1
Cl.Cl.Cn1cncc1CN
Cc1ccc(C(=O)N[Dy])c(Nc2nc(NCc3cncn3C)nc(NC3CCC(=O)CC3)n2)c1C
HSA
1
83,219,411
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cnc(Cl)nc1N
Cl.NCCC(=O)NCc1ccccc1
Cc1cnc(Cl)nc1Nc1nc(NCCC(=O)NCc2ccccc2)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1