id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
229,184,700
O=C(Nc1ncc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1ccc(O)c(CN)n1.Cl.Cl
CC(O)(CN)c1ccsc1
Cc1ccc(O)c(CNc2nc(NCC(C)(O)c3ccsc3)nc(Nc3ncc(Br)cc3C(=O)N[Dy])n2)n1
BRD4
1
261,254,931
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccs1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
C=CCNC(=O)CN.Cl
C=CCNC(=O)CNc1nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])nc(N[C@H](CC(=O)N[Dy])c2cccs2)n1
BRD4
1
13,949,976
CC(C)(C)OC(=O)CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O
CC(C)(C)OC(=O)CCC(Nc1nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])nc(Nc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)n1)C(=O)N[Dy]
BRD4
1
18,199,182
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCCC1OCCc2ccccc21
Nc1ccc2c(c1)CCCC2=O
CC(C)CC(Nc1nc(NCCC2OCCc3ccccc32)nc(Nc2ccc3c(c2)CCCC3=O)n1)C(=O)N[Dy]
BRD4
1
83,178,929
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(O)ccc1N
Cc1n[nH]c(N)c1C
Cc1cc(O)ccc1Nc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2[nH]nc(C)c2C)n1
sEH
1
96,522,409
O=C(N[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Br.Br.NCC1CCCN1c1cccnn1
O=C(N[Dy])[C@H](Cc1ccc(Cl)cc1Cl)Nc1nc(NCc2cnc3n2CCOC3)nc(NCC2CCCN2c2cccnn2)n1
HSA
1
284,341,337
O=C(O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1ncco1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(Nc4ncco4)nc(N4[C@H](C(=O)N[Dy])C[C@@H]5CCCC[C@@H]54)n3)ccc2[nH]1
sEH
1
284,889,702
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.N#Cc1ccc(CN)nc1
CN1CC(CCN)CC1=O
CN1CC(CCNc2nc(NCc3ccc(C#N)cn3)nc(N3Cc4cc(O)ccc4C[C@H]3C(=O)N[Dy])n2)CC1=O
BRD4
1
190,447,662
O=C(Nc1ccc(C(=O)O)cc1Cl)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
N#Cc1c(N)cccc1F
N#Cc1c(F)cccc1Nc1nc(Nc2ccc(C(=O)N[Dy])cc2Cl)nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])n1
BRD4
1
52,082,514
Cc1cc(C)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
NCc1nc(-c2ccsc2)no1
Cc1cc(C)c(Nc2nc(NCc3nc(-c4ccsc4)no3)nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])n2)c(C(=O)N[Dy])c1
BRD4
1
131,498,036
O=C(N[C@H]1CC[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
Cc1cccc(CCCN)n1
Cc1cccc(CCCNc2nc(NCCC3CSC3)nc(N[C@H]3CC[C@@H](C(=O)N[Dy])C3)n2)n1
sEH
1
82,608,080
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cl)nc1Cl
Cl.NCCCNC(=O)C1CCC1
O=C(N[Dy])C1CCC(CNc2nc(NCCCNC(=O)C3CCC3)nc(Nc3ccc(Cl)nc3Cl)n2)CC1
sEH
1
200,972,992
O=C(Nc1ccc(F)c(C(=O)O)c1F)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
COc1ncc(N)cc1C(F)(F)F
COc1ncc(Nc2nc(NCc3cncc(F)c3)nc(Nc3ccc(F)c(C(=O)N[Dy])c3F)n2)cc1C(F)(F)F
HSA
1
237,201,111
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
NCC[C@@H]1COC[C@H]1O
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
O=C(CC(Nc1nc(NCC[C@@H]2COC[C@H]2O)nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])n1)c1ccc(Br)cc1)N[Dy]
BRD4
1
10,762,005
C=CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1ccc2c(c1)CNC2=O
Cl.NCc1cc(Br)no1
C=CC[C@H](Nc1nc(NCc2cc(Br)no2)nc(Nc2ccc3c(c2)CNC3=O)n1)C(=O)N[Dy]
BRD4
1
187,685,432
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
COc1cncc(N)c1
Cl.NCc1cc(Br)no1
COc1cncc(Nc2nc(NCc3cc(Br)no3)nc(Nc3ccc(C(=O)N[Dy])cc3)n2)c1
sEH
1
28,493,790
COc1c(F)ccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
CNC(=O)c1ccc(N)cc1F
NCc1ccc(C(=O)N2CCCC2)cc1
CNC(=O)c1ccc(Nc2nc(NCc3ccc(C(=O)N4CCCC4)cc3)nc(Nc3c(C(=O)N[Dy])ccc(F)c3OC)n2)cc1F
BRD4
1
69,136,367
N#Cc1ccc([C@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Cl.Cl.NCc1ccc(O)c2ncccc12
Nc1nc(=O)[nH]cc1Br
N#Cc1ccc([C@H](CC(=O)N[Dy])Nc2nc(NCc3ccc(O)c4ncccc34)nc(Nc3nc(=O)[nH]cc3Br)n2)cc1
sEH
1
271,831,469
O=C(O)C[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1(O)C2C3CC4C5C3CC2C5C41
COC(=O)c1ccc(N)cc1C
COC(=O)c1ccc(Nc2nc(NCC3(O)C4C5CC6C7C5CC4C7C63)nc(N[C@H](CC(=O)N[Dy])Cc3ccc([N+](=O)[O-])cc3)n2)cc1C
sEH
1
108,751,300
O=C(N[C@@H](Cc1csc2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cl)cn1
Nc1nc(=O)[nH]cc1Br
O=C(N[Dy])[C@H](Cc1csc2ccccc12)Nc1nc(Nc2ccc(Cl)cn2)nc(Nc2nc(=O)[nH]cc2Br)n1
HSA
1
65,277,760
N#Cc1ccc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Nc1cccc2ocnc12
Cn1ccc2cc(N)ccc21
Cn1ccc2cc(Nc3nc(Nc4cccc5ocnc45)nc(N[C@H](Cc4ccc(C#N)cc4)C(=O)N[Dy])n3)ccc21
HSA
1
102,878,746
O=C(N[C@@H](Cc1ccccc1F)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC=Cc1cccnc1
Cc1c(Br)cncc1CN.Cl.Cl
Cc1c(Br)cncc1CNc1nc(NCC=Cc2cccnc2)nc(N[C@@H](Cc2ccccc2F)C(=O)N[Dy])n1
HSA
1
138,172,654
O=C(Nc1c(C(=O)O)ccc(Br)c1F)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
Cl.NCCCN1C(=O)CCC1=O
O=C(N[Dy])c1ccc(Br)c(F)c1Nc1nc(NCCCN2C(=O)CCC2=O)nc(Nc2ccc(Cn3ccnc3)cc2)n1
HSA
1
262,877,890
O=C(O)C[C@H](C/C=C/c1ccccc1)NC(=O)OCC1c2ccccc2-c2ccccc21
CSC1(CN)CCOCC1.Cl
Cc1cc(CN)c(C)o1
CSC1(CNc2nc(NCc3cc(C)oc3C)nc(N[C@@H](C/C=C/c3ccccc3)CC(=O)N[Dy])n2)CCOCC1
HSA
1
284,907,291
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1(O)C2C3CC4C5C3CC2C5C41
Nc1ccc2c(c1)CC(=O)N2
O=C1Cc2cc(Nc3nc(NCC4(O)C5C6CC7C8C6CC5C8C74)nc(N4Cc5cc(O)ccc5C[C@H]4C(=O)N[Dy])n3)ccc2N1
BRD4
1
209,599,087
O=C(Nc1cccc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cc1ccncc1N
Nc1nc(Cl)c2[nH]cnc2n1
Cc1ccncc1Nc1nc(Nc2cccc(C(=O)N[Dy])c2)nc(Nc2nc(Cl)c3[nH]cnc3n2)n1
HSA
1
82,479,023
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCCCCN1CCCC1
COc1ccc([N+](=O)[O-])c(N)n1
COc1ccc([N+](=O)[O-])c(Nc2nc(NCCCCN3CCCC3)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)n1
sEH
1
282,569,431
O=C(O)[C@@H]1CSCN1C(=O)OCC1c2ccccc2-c2ccccc21
Cc1ccc(N)nn1
Nc1n[nH]c2cc(Cl)ccc12
Cc1ccc(Nc2nc(Nc3n[nH]c4cc(Cl)ccc34)nc(N3CSC[C@H]3C(=O)N[Dy])n2)nn1
HSA
1
82,614,149
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(F)c(Cl)c1F
Cc1ccsc1CN
Cc1ccsc1CNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2ccc(F)c(Cl)c2F)n1
sEH
1
13,734,347
CC(C)(C)OC(=O)CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.NCc1csc(=O)[nH]1
Cl.Cl.NCC=Cc1cccnc1
CC(C)(C)OC(=O)CCC(Nc1nc(NCC=Cc2cccnc2)nc(NCc2csc(=O)[nH]2)n1)C(=O)N[Dy]
sEH
1
82,574,816
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cc(F)c(F)cc1[N+](=O)[O-]
Cc1ccc(N)c(CO)c1
Cc1ccc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3cc(F)c(F)cc3[N+](=O)[O-])n2)c(CO)c1
sEH
1
50,765,892
Cc1cc(C(=O)O)ccc1NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1ccnc(C(N)=O)c1
Br.Br.NCC1CCCN1c1cccnn1
Cc1cc(C(=O)N[Dy])ccc1Nc1nc(NCc2ccnc(C(N)=O)c2)nc(NCC2CCCN2c2cccnn2)n1
BRD4
1
82,903,862
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1cnc(SC)nc1N
COc1ccc(N)cc1Cl.Cl
CCOC(=O)c1cnc(SC)nc1Nc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2ccc(OC)c(Cl)c2)n1
sEH
1
222,068,989
O=C(Nc1cnccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
Nc1nc2ccc(Cl)cc2o1
O=C(N[Dy])c1ccncc1Nc1nc(Nc2ccc(Cn3ccnc3)cc2)nc(Nc2nc3ccc(Cl)cc3o2)n1
HSA
1
83,028,482
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1c(F)ccc(F)c1CN.Cl
COC(=O)c1sc(-c2ccc(Cl)cc2)cc1N
COC(=O)c1sc(-c2ccc(Cl)cc2)cc1Nc1nc(NCc2c(F)ccc(F)c2OC)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
227,577,876
O=C(Nc1nc2ccc(C(=O)O)cc2s1)OCC1c2ccccc2-c2ccccc21
Nc1ccc2cn[nH]c2c1
Cn1c(N)cc(=O)n(C)c1=O
Cn1c(Nc2nc(Nc3ccc4cn[nH]c4c3)nc(Nc3nc4ccc(C(=O)N[Dy])cc4s3)n2)cc(=O)n(C)c1=O
BRD4
1
81,908,942
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1scnc1N
CC(CN)OC(C)(C)C.Cl
COC(=O)c1scnc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(NCC(C)OC(C)(C)C)n1
sEH
1
17,617,548
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COC(=O)c1ccc(N)cc1OC
Cc1nn(C)c2ncc(CN)cc12.Cl
COC(=O)c1ccc(Nc2nc(NCc3cnc4c(c3)c(C)nn4C)nc(NC(CC(C)C)C(=O)N[Dy])n2)cc1OC
BRD4
1
163,065,321
O=C(Nc1cc(C(=O)O)cc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
NCC1(CO)CCOC1
Nc1nccc(=O)[nH]1
O=C(O)c1cc(Nc2nc(NCC3(CO)CCOC3)nc(Nc3nccc(=O)[nH]3)n2)cc(C(=O)N[Dy])c1
BRD4
1
260,167,443
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc([N+](=O)[O-])c1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
CN1CCN(Cc2ccc(N)cc2C(F)(F)F)CC1
CN1CCN(Cc2ccc(Nc3nc(Nc4cc(N5CCNCC5)ccc4[N+](=O)[O-])nc(N[C@H](CC(=O)N[Dy])c4cccc([N+](=O)[O-])c4)n3)cc2C(F)(F)F)CC1
BRD4
1
83,023,076
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COCc1ccccc1CN
CC(CN)S(C)=O
COCc1ccccc1CNc1nc(NCC(C)S(C)=O)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
67,164,674
N#Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
N#Cc1cc(N)ccc1F
Br.Br.NCC1CCCN1c1cccnn1
N#Cc1ccc(C[C@H](Nc2nc(NCC3CCCN3c3cccnn3)nc(Nc3ccc(F)c(C#N)c3)n2)C(=O)N[Dy])cc1
sEH
1
236,638,748
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
COCCNC(=O)CN.Cl
Cc1cc2cc(CN)ccc2[nH]1
COCCNC(=O)CNc1nc(NCc2ccc3[nH]c(C)cc3c2)nc(NC(CC(=O)N[Dy])c2ccc(Br)cc2)n1
sEH
1
74,207,814
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CCON(CC)C(=O)CN.Cl
COc1cc(CN)sn1.Cl.Cl
CCON(CC)C(=O)CNc1nc(NCc2cc(OC)ns2)nc(NC(Cc2ccccc2)C(=O)N[Dy])n1
BRD4
1
227,152,644
O=C(Nc1nc2ccc(C(=O)O)cc2s1)OCC1c2ccccc2-c2ccccc21
Cl.NCC(=O)NC1CCC1
Cl.Cn1cc(N)ccc1=O
Cn1cc(Nc2nc(NCC(=O)NC3CCC3)nc(Nc3nc4ccc(C(=O)N[Dy])cc4s3)n2)ccc1=O
BRD4
1
105,459,084
O=C(N[C@@H](Cc1ccco1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
CC(C)(C)OC(=O)N1CCC(n2cc(N)cn2)CC1
CC(C)(C)OC(=O)N1CCC(n2cc(Nc3nc(Nc4cc(N5CCNCC5)ccc4[N+](=O)[O-])nc(N[C@@H](Cc4ccco4)C(=O)N[Dy])n3)cn2)CC1
BRD4
1
257,135,298
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Cl)cc1
CC(=O)SCCN.Cl
Cn1cc(-c2ccccc2CN)cn1
CC(=O)SCCNc1nc(NCc2ccccc2-c2cnn(C)c2)nc(N[C@H](CC(=O)N[Dy])c2ccc(Cl)cc2)n1
BRD4
1
74,283,678
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1nc(Cl)c(Cl)nc1N
Nc1cc(Cl)c(O)c(Cl)c1
COC(=O)c1nc(Cl)c(Cl)nc1Nc1nc(Nc2cc(Cl)c(O)c(Cl)c2)nc(NC(Cc2ccccc2)C(=O)N[Dy])n1
BRD4
1
292,246,257
O=C(O)[C@H]1C[C@H](O)CN1C(=O)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cc1OC
CCOC(=O)c1nonc1N
CCOC(=O)c1nonc1Nc1nc(Nc2ccc(OC)c(OC)c2)nc(N2C[C@@H](O)C[C@@H]2C(=O)N[Dy])n1
BRD4
1
195,934,207
O=C(Nc1ccc(C(=O)O)nc1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(F)cn1
Nc1nncs1
O=C(N[Dy])c1ccc(Nc2nc(Nc3ccc(F)cn3)nc(Nc3nncs3)n2)cn1
HSA
1
203,299,885
O=C(Nc1ccc(I)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
NCc1noc2c1COCC2
O=C(N[Dy])c1cc(I)ccc1Nc1nc(NCc2noc3c2COCC3)nc(NCc2cnc3n2CCOC3)n1
HSA
1
16,813,363
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Cl.NCC=Cc1cccnc1
Cl.NCc1ccc(-c2nnn[nH]2)cc1
CC(C)(C)OCC(Nc1nc(NCC=Cc2cccnc2)nc(NCc2ccc(-c3nnn[nH]3)cc2)n1)C(=O)N[Dy]
HSA
1
251,084,540
O=C(O)C[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
CCOC(=O)c1c[nH]nc1N
CCOC(=O)c1c[nH]nc1Nc1nc(NCc2cncc(F)c2)nc(N[C@@H](CC(=O)N[Dy])Cc2ccc([N+](=O)[O-])cc2)n1
sEH
1
126,137,228
O=C(N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)c(O)c(Cl)c1
NCC1CCN(c2ccncc2)CC1
O=C(N[Dy])[C@@H](Cc1ccc([N+](=O)[O-])cc1)Nc1nc(NCC2CCN(c3ccncc3)CC2)nc(Nc2cc(Cl)c(O)c(Cl)c2)n1
sEH
1
74,782,389
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cn1nccc1CN1C[C@@H](F)C[C@H]1CN
Cl.NCc1cc(Br)no1
Cn1nccc1CN1C[C@@H](F)C[C@H]1CNc1nc(NCc2cc(Br)no2)nc(NC(Cc2ccccc2)C(=O)N[Dy])n1
BRD4
1
83,187,914
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1ccc(N)c(Cl)n1
Cl.Cl.NCc1ccc2ccccc2n1
Cc1ccc(Nc2nc(NCc3ccc4ccccc4n3)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)c(Cl)n1
sEH
1
82,567,781
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)nc(Cl)n1
COC(=O)c1sc(-c2ccc(Cl)cc2)cc1N
COC(=O)c1sc(-c2ccc(Cl)cc2)cc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2cc(Cl)nc(Cl)n2)n1
sEH
1
81,909,494
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1scnc1N
CS(=O)(=O)c1cccc(N)c1
COC(=O)c1scnc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2cccc(S(C)(=O)=O)c2)n1
sEH
1
83,657,264
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)ncn1
Cl.NCC1CC12CCOCC2
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NCC3CC34CCOCC4)nc(Nc3cc(Cl)ncn3)n2)CC1
sEH
1
278,759,978
O=C(O)Cc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Nc1ccc([N+](=O)[O-])cn1
NCC1CCCCC(F)(F)C1
O=C(Cc1ccc(Nc2nc(NCC3CCCCC(F)(F)C3)nc(Nc3ccc([N+](=O)[O-])cn3)n2)cc1)N[Dy]
sEH
1
67,224,734
N#Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
NCCC1CSC1
Cc1n[nH]c(N)c1C
Cc1n[nH]c(Nc2nc(NCCC3CSC3)nc(N[C@@H](Cc3ccc(C#N)cc3)C(=O)N[Dy])n2)c1C
sEH
1
62,962,776
Cn1cc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)c2ccccc21
Nc1cc(Cl)ncn1
Cc1ccsc1CN
Cc1ccsc1CNc1nc(Nc2cc(Cl)ncn2)nc(N[C@H](Cc2cn(C)c3ccccc23)C(=O)N[Dy])n1
BRD4
1
192,709,472
O=C(Nc1ccc(C(=O)O)cc1O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNCC2
Cl.Cl.Cn1cncc1CN
Cn1cncc1CNc1nc(Nc2ccc3c(c2)CNCC3)nc(Nc2ccc(C(=O)N[Dy])cc2O)n1
sEH
1
121,104,508
O=C(N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(N)ccc1F
Cl.Cl.NCc1cncc(F)c1
COC(=O)c1cc(Nc2nc(NCc3cncc(F)c3)nc(N[C@H](Cc3ccc(Cl)c(Cl)c3)C(=O)N[Dy])n2)ccc1F
HSA
1
200,973,065
O=C(Nc1ccc(F)c(C(=O)O)c1F)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Cc1cc(CN)c(C)o1
Cc1cc(CNc2nc(NCc3cncc(F)c3)nc(Nc3ccc(F)c(C(=O)N[Dy])c3F)n2)c(C)o1
sEH
1
75,054,664
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2cnccc2c1
CC(CN)Cn1cccn1
CC(CNc1nc(Nc2ccc3cnccc3c2)nc(NC(Cc2ccccc2)C(=O)N[Dy])n1)Cn1cccn1
HSA
1
127,270,256
O=C(N[C@H](Cc1ccccc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cl)cc1F
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(Nc4ccc(Cl)cc4F)nc(N[C@H](Cc4ccccc4Cl)C(=O)N[Dy])n3)ccc2[nH]1
sEH
1
33,327,285
COc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)cc1OC
Cl.NCc1ccc(-c2c[nH]c(=O)[nH]c2=O)cc1
Cl.Cn1cc(N)ccc1=O
COc1cc(Nc2nc(NCc3ccc(-c4c[nH]c(=O)[nH]c4=O)cc3)nc(Nc3ccc(=O)n(C)c3)n2)c(C(=O)N[Dy])cc1OC
BRD4
1
13,950,138
CC(C)(C)OC(=O)CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Nc1nc2ccccc2[nH]1
CC(C)(C)OC(=O)CCC(Nc1nc(Nc2nc3ccccc3[nH]2)nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])n1)C(=O)N[Dy]
BRD4
1
81,823,958
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCOC(CN)CN(C)C
COC1CCC(CCN)CC1
CCOC(CNc1nc(NCCC2CCC(OC)CC2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1)CN(C)C
sEH
1
122,975,937
O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)COC2=O
Cn1cc(C(F)F)c(CN)n1
Cn1cc(C(F)F)c(CNc2nc(Nc3ccc4c(c3)COC4=O)nc(N[C@H](Cc3ccc(Cl)cc3)C(=O)N[Dy])n2)n1
BRD4
1
83,246,114
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1sc(C)c(CN)c1Br.Cl
Nc1ccc2c(c1)CNC2=O
Cc1sc(C)c(CNc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3ccc4c(c3)CNC4=O)n2)c1Br
sEH
1
83,024,846
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CO[C@@H]1COC[C@H]1n1cc(CN)nn1.Cl
CCSc1ccc(CN)cc1
CCSc1ccc(CNc2nc(NCc3cn([C@@H]4COC[C@H]4OC)nn3)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)cc1
sEH
1
201,849,466
O=C(Nc1ccc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cncc(N)n1
Cc1cc(CN)c(C)o1
COc1cncc(Nc2nc(NCc3cc(C)oc3C)nc(Nc3ccc(F)cc3C(=O)N[Dy])n2)n1
HSA
1
285,141,645
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
NC[C@@H]1CCC(=O)N1
Cl.NCC1CCCC2(CCC2)C1O
O=C1CC[C@@H](CNc2nc(NCC3CCCC4(CCC4)C3O)nc(N3Cc4cc(O)ccc4C[C@H]3C(=O)N[Dy])n2)N1
BRD4
1
164,568,762
O=C(Nc1cc(C(=O)O)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CC(CN)S(N)(=O)=O.Cl
Nc1ccc2c(c1)COC2=O
CC(CNc1nc(Nc2ccc3c(c2)COC3=O)nc(Nc2cc(C(=O)N[Dy])ccc2C(=O)O)n1)S(N)(=O)=O
BRD4
1
83,139,269
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(C)c(CN)c(=O)[nH]1.Cl
COC(=O)c1scc(C)c1N
COC(=O)c1scc(C)c1Nc1nc(NCc2c(C)cc(C)[nH]c2=O)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
82,182,002
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCCCN1CCNC(=O)C1
COC(=O)c1nccnc1N
COC(=O)c1nccnc1Nc1nc(NCCCN2CCNC(=O)C2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1
sEH
1
110,071,979
O=C(N[C@@H]1CC[C@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
CC(C)(CN)CCC#N
Cc1cc(CN)cc(Cl)n1.Cl.Cl
Cc1cc(CNc2nc(NCC(C)(C)CCC#N)nc(N[C@@H]3CC[C@H](C(=O)N[Dy])C3)n2)cc(Cl)n1
sEH
1
22,545,046
CCOc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(Cl)cc1C(=O)O
NCC1CN2CCN1CC2
COc1ccc2nc(N)sc2c1
CCOc1cc(Nc2nc(NCC3CN4CCN3CC4)nc(Nc3nc4ccc(OC)cc4s3)n2)c(Cl)cc1C(=O)N[Dy]
HSA
1
47,501,254
Cc1cc(Br)c(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Cc1cc([N+](=O)[O-])c(N)cc1Cl
Cc1cc([N+](=O)[O-])c(Nc2nc(NCc3cnc4n3CCOC4)nc(Nc3cc(C(=O)N[Dy])c(Br)cc3C)n2)cc1Cl
HSA
1
103,992,733
O=C(N[C@@H](Cc1cccnc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Cc1ccc(CN)c(Cl)n1
Cc1ccc(CNc2nc(NCc3ccc(O)c4ncccc34)nc(N[C@@H](Cc3cccnc3)C(=O)N[Dy])n2)c(Cl)n1
HSA
1
82,524,611
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1ccccc1CS(=O)(=O)N1CCOCC1
CN1CCN(Cc2cccc(N)c2)CC1
CN1CCN(Cc2cccc(Nc3nc(NCc4ccccc4CS(=O)(=O)N4CCOCC4)nc(NCC4CCC(C(=O)N[Dy])CC4)n3)c2)CC1
sEH
1
66,647,019
N#Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
COC(=O)c1ccc(N)cc1OC
NCC1CSCCN1Cc1ccccc1
COC(=O)c1ccc(Nc2nc(NCC3CSCCN3Cc3ccccc3)nc(N[C@@H](Cc3ccc(C#N)cc3)C(=O)N[Dy])n2)cc1OC
BRD4
1
82,132,871
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cnc(N)cn1
CC(C)(C)c1ocnc1CN.Cl
Cc1cnc(Nc2nc(NCc3ncoc3C(C)(C)C)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)cn1
sEH
1
258,107,038
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Cl)cc1
Nc1cccc2cnccc12
NCCS(=O)Cc1ccccc1
O=C(C[C@@H](Nc1nc(NCCS(=O)Cc2ccccc2)nc(Nc2cccc3cnccc23)n1)c1ccc(Cl)cc1)N[Dy]
HSA
1
20,109,621
CCC(C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Cl.NCc1ccc[n+]([O-])c1
NCc1ccc(NC(=O)c2ccco2)cc1
CCC(C)C(Nc1nc(NCc2ccc(NC(=O)c3ccco3)cc2)nc(NCc2ccc[n+]([O-])c2)n1)C(=O)N[Dy]
BRD4
1
83,586,119
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NC[C@@H]1C[C@@H]2C=C[C@H]1C2
Nc1cccc2c(=O)[nH][nH]c(=O)c12
O=c1[nH][nH]c(=O)c2c(Nc3nc(NC[C@@H]4C[C@@H]5C=C[C@H]4C5)nc(NC[C@H]4CC[C@H](C(=O)N[Dy])CC4)n3)cccc12
sEH
1
82,779,902
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ncccc1F
Cl.NCC1CCCOC1
O=C(N[Dy])C1CCC(CNc2nc(NCC3CCCOC3)nc(Nc3ncccc3F)n2)CC1
sEH
1
123,726,836
O=C(N[C@H](Cc1ccc(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCCS(=O)(=O)c1ccc(Cl)cc1
COc1cccc(F)c1CN
COc1cccc(F)c1CNc1nc(NCCS(=O)(=O)c2ccc(Cl)cc2)nc(N[C@H](Cc2ccc(F)c(F)c2)C(=O)N[Dy])n1
sEH
1
213,711,104
O=C(Nc1cccc(I)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(Cl)ccc1N
Nc1nc(Cl)c2[nH]cnc2n1
COC(=O)c1cc(Cl)ccc1Nc1nc(Nc2nc(Cl)c3[nH]cnc3n2)nc(Nc2cccc(I)c2C(=O)N[Dy])n1
sEH
1
13,258,839
CC(C)(C)OC(=O)CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COC(=O)c1ccc(N)cc1OC
CNC(=O)COCCN.Cl
CNC(=O)COCCNc1nc(Nc2ccc(C(=O)OC)c(OC)c2)nc(NC(CCC(=O)OC(C)(C)C)C(=O)N[Dy])n1
BRD4
1
167,712,146
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
Nc1cncc(F)c1
CCOC(=O)c1nnc(N)o1
CCOC(=O)c1nnc(Nc2nc(Nc3cncc(F)c3)nc(Nc3cc(C(=O)N[Dy])ccc3Cl)n2)o1
sEH
1
281,613,747
O=C(O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cn1cc(CN)c(Br)n1
COc1nc(C)ccc1CN
COc1nc(C)ccc1CNc1nc(NCc2cn(C)nc2Br)nc(N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)N[Dy])n1
BRD4
1
81,592,771
O=C(NC1(C(=O)O)CCc2ccccc21)OCC1c2ccccc2-c2ccccc21
Nc1ccc2ncoc2c1
Cc1nc(Cl)ccc1N
Cc1nc(Cl)ccc1Nc1nc(Nc2ccc3ncoc3c2)nc(NC2(C(=O)N[Dy])CCc3ccccc32)n1
HSA
1
157,535,779
O=C(Nc1cc(Br)c(Cl)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
CN(CC(F)(F)F)C(=O)CN.Cl
CN(CC(F)(F)F)C(=O)CNc1nc(NCc2cnc3n2CCOC3)nc(Nc2cc(Br)c(Cl)cc2C(=O)N[Dy])n1
HSA
1
126,103,221
O=C(N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCc1ccccc1CS(=O)(=O)N1CCOCC1
Nc1ccc2ncccc2c1
O=C(N[Dy])[C@@H](Cc1ccc([N+](=O)[O-])cc1)Nc1nc(NCc2ccccc2CS(=O)(=O)N2CCOCC2)nc(Nc2ccc3ncccc3c2)n1
BRD4
1
264,289,095
O=C(O)C[C@H](Cc1c(F)c(F)c(F)c(F)c1F)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cc(C(F)(F)F)co1
Cl.Cn1cc(CN)c(Br)n1
Cn1cc(CNc2nc(NCc3cc(C(F)(F)F)co3)nc(N[C@H](CC(=O)N[Dy])Cc3c(F)c(F)c(F)c(F)c3F)n2)c(Br)n1
BRD4
1
18,216,264
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCCc1ccncc1F
NCC1(c2ccc(Cl)cc2Cl)CCCC1
CC(C)CC(Nc1nc(NCCc2ccncc2F)nc(NCC2(c3ccc(Cl)cc3Cl)CCCC2)n1)C(=O)N[Dy]
BRD4
1
82,509,923
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1cc(-c2ccccc2)[nH]n1
Nc1nccnc1Br
O=C(N[Dy])C1CCC(CNc2nc(NCc3cc(-c4ccccc4)[nH]n3)nc(Nc3nccnc3Br)n2)CC1
sEH
1