id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
261,296,431
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccs1
Nc1ccc(F)nc1
CCOC(=O)c1cc(N)[nH]n1
CCOC(=O)c1cc(Nc2nc(Nc3ccc(F)nc3)nc(N[C@H](CC(=O)N[Dy])c3cccs3)n2)[nH]n1
HSA
1
81,579,951
O=C(NC1(C(=O)O)CCc2ccccc21)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)COC2=O
Cl.Cn1cc(N)ccc1=O
Cn1cc(Nc2nc(Nc3ccc4c(c3)COC4=O)nc(NC3(C(=O)N[Dy])CCc4ccccc43)n2)ccc1=O
BRD4
1
63,758,554
N#Cc1ccc(C[C@@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Cl.NCC1CCCC1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCC4CCCC4)nc(N[C@H](CC(=O)N[Dy])Cc4ccc(C#N)cc4)n3)ccc2[nH]1
HSA
1
139,261,376
O=C(Nc1c(C(=O)O)ccc2ccccc12)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
COc1ccnc(N)n1
COc1ccnc(Nc2nc(Nc3ccc(Cn4ccnc4)cc3)nc(Nc3c(C(=O)N[Dy])ccc4ccccc34)n2)n1
sEH
1
188,082,967
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Cn1cncc1C(CN)N1CCCC1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCC(c4cncn4C)N4CCCC4)nc(Nc4ccc(C(=O)N[Dy])cc4)n3)ccc2[nH]1
HSA
1
83,260,556
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC1CCN(C(N)=O)C1
NCC1(Cc2ccccc2)CC1
NC(=O)N1CCC(CNc2nc(NCC3(Cc4ccccc4)CC3)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)C1
sEH
1
225,992,125
O=C(Nc1nc2cc(C(=O)O)ccc2[nH]1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC=Cc1cccnc1
Cl.Cl.Cn1cncc1CN
Cn1cncc1CNc1nc(NCC=Cc2cccnc2)nc(Nc2nc3cc(C(=O)N[Dy])ccc3[nH]2)n1
HSA
1
83,151,044
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(F)ncc1CN
CCC1=NN(Cc2ccccc2C)C(=O)C1CCN
CCC1=NN(Cc2ccccc2C)C(=O)C1CCNc1nc(NCc2cnc(F)cc2C)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
106,406,468
O=C(N[C@@H](Cc1cccs1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCC1(CO)CC=CC1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCC4(CO)CC=CC4)nc(N[C@@H](Cc4cccs4)C(=O)N[Dy])n3)ccc2[nH]1
sEH
1
167,197,072
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Nc1n[nH]c2ccc([N+](=O)[O-])cc12
O=C(N[Dy])c1ccc(Cl)c(Nc2nc(NCc3cncc(F)c3)nc(Nc3n[nH]c4ccc([N+](=O)[O-])cc34)n2)c1
HSA
1
82,613,588
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(F)c(Cl)c1F
CCc1cc(N)n[nH]1
CCc1cc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3ccc(F)c(Cl)c3F)n2)n[nH]1
sEH
1
125,218,738
O=C(N[C@H](Cc1ccc(I)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cncc(F)c1
COC(=O)c1ccc2nc(N)sc2c1
COC(=O)c1ccc2nc(Nc3nc(Nc4cncc(F)c4)nc(N[C@H](Cc4ccc(I)cc4)C(=O)N[Dy])n3)sc2c1
HSA
1
66,694,872
N#Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
COc1c(N)cccc1F
COc1nc(C)ccc1CN
COc1nc(C)ccc1CNc1nc(Nc2cccc(F)c2OC)nc(N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[Dy])n1
BRD4
1
55,646,247
Cc1ccc(C(CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
CC1CC(CN)C(C)O1
Cl.Cn1cc(N)ccc1=O
Cc1ccc(C(CC(=O)N[Dy])Nc2nc(NCC3CC(C)OC3C)nc(Nc3ccc(=O)n(C)c3)n2)cc1
BRD4
1
105,920,395
O=C(N[C@@H](Cc1cccs1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cc(F)ccc1N
Cc1cc2cc(CN)ccc2[nH]1
COc1cc(F)ccc1Nc1nc(NCc2ccc3[nH]c(C)cc3c2)nc(N[C@@H](Cc2cccs2)C(=O)N[Dy])n1
HSA
1
107,861,091
O=C(N[C@@H](Cc1csc2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21
C=C(Cl)CN.Cl
COc1cc(CN)sn1.Cl.Cl
C=C(Cl)CNc1nc(NCc2cc(OC)ns2)nc(N[C@@H](Cc2csc3ccccc23)C(=O)N[Dy])n1
BRD4
1
18,232,374
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCc1cc(-c2ccccc2)[nH]n1
N#Cc1cccnc1N
CC(C)CC(Nc1nc(NCc2cc(-c3ccccc3)[nH]n2)nc(Nc2ncccc2C#N)n1)C(=O)N[Dy]
BRD4
1
187,889,871
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc[n+]([O-])c1
C=CCOCCN
C=CCOCCNc1nc(NCc2ccc[n+]([O-])c2)nc(Nc2ccc(C(=O)N[Dy])cc2)n1
BRD4
1
63,053,560
Cn1cc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)c2ccccc21
Nc1ccc2c(c1)CC(=O)N2
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(Nc4ccc5c(c4)CC(=O)N5)nc(N[C@H](Cc4cn(C)c5ccccc45)C(=O)N[Dy])n3)ccc2[nH]1
HSA
1
55,584,684
Cc1ccc(C(CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
CC(=O)SCCN.Cl
CCSc1ccc(CN)cc1
CCSc1ccc(CNc2nc(NCCSC(C)=O)nc(NC(CC(=O)N[Dy])c3ccc(C)cc3)n2)cc1
BRD4
1
54,982,027
Cc1ccc(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
CC(C)(CN)C(=O)N1CCCC1
Cc1ccc(C(=O)N[Dy])cc1Nc1nc(NCc2cncc(F)c2)nc(NCC(C)(C)C(=O)N2CCCC2)n1
HSA
1
21,901,607
CCOc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(Cl)cc1C(=O)O
CCOC(=O)c1ncccc1N
Cc1ccc(C)c(CN)n1
CCOC(=O)c1ncccc1Nc1nc(NCc2nc(C)ccc2C)nc(Nc2cc(OCC)c(C(=O)N[Dy])cc2Cl)n1
sEH
1
82,050,812
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(C#N)cnc1N
NCC1(O)CCCC1
Cc1cc(C#N)cnc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(NCC2(O)CCCC2)n1
sEH
1
249,272,775
O=C(O)C[C@@H](Cc1ccc(F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
CC(CN)c1nccs1
CC(CNc1nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])nc(N[C@@H](CC(=O)N[Dy])Cc2ccc(F)cc2)n1)c1nccs1
BRD4
1
83,757,812
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)OCCCO2
Nc1c2c(cc3c1CCC3)CCC2
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(Nc3ccc4c(c3)OCCCO4)nc(Nc3c4c(cc5c3CCC5)CCC4)n2)CC1
sEH
1
243,973,303
O=C(O)C[C@@H](Cc1ccc(Br)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cnccn1
Nc1nc(Br)cn2ccnc12
O=C(C[C@@H](Cc1ccc(Br)cc1)Nc1nc(Nc2cnccn2)nc(Nc2nc(Br)cn3ccnc23)n1)N[Dy]
HSA
1
216,579,069
O=C(Nc1ccccc1C(=O)c1ccccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)cnc1Cl
Nc1nc(F)nc2nc[nH]c12
O=C(N[Dy])c1ccccc1C(=O)c1ccccc1Nc1nc(Nc2cc(Cl)cnc2Cl)nc(Nc2nc(F)nc3nc[nH]c23)n1
BRD4
1
17,299,311
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1ccc2c(c1)CNC2=O
Nc1cccc(N2CCOCC2)c1
CC(C)(C)OCC(Nc1nc(Nc2cccc(N3CCOCC3)c2)nc(Nc2ccc3c(c2)CNC3=O)n1)C(=O)N[Dy]
BRD4
1
188,047,603
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Nc1nncs1
O=C(N[Dy])c1ccc(Nc2nc(NCc3cnc4n3CCOC4)nc(Nc3nncs3)n2)cc1
HSA
1
59,669,117
Cc1cccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
NCc1cnn(Cc2ccccc2)c1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCc4cnn(Cc5ccccc5)c4)nc(Nc4c(C)cccc4C(=O)N[Dy])n3)ccc2[nH]1
sEH
1
152,084,786
O=C(Nc1c(F)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1ccnc(C(N)=O)c1
Cl.Cl.NCc1cncc(F)c1
NC(=O)c1cc(CNc2nc(NCc3cncc(F)c3)nc(Nc3c(F)cccc3C(=O)N[Dy])n2)ccn1
sEH
1
83,140,484
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(C)c(N)c([N+](=O)[O-])c1
CO[C@@H]1COC[C@H]1n1cc(CN)nn1.Cl
CO[C@@H]1COC[C@H]1n1cc(CNc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3c(C)cc(C)cc3[N+](=O)[O-])n2)nn1
sEH
1
286,238,301
O=C(O)[C@@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
NCc1c(F)cccc1N1CCCC1
COc1ccc(N)cc1OC
COc1ccc(Nc2nc(NCc3c(F)cccc3N3CCCC3)nc(N3Cc4ccccc4C[C@H]3C(=O)N[Dy])n2)cc1OC
BRD4
1
190,655,839
O=C(Nc1ccc(C(=O)O)cc1Cl)OCC1c2ccccc2-c2ccccc21
Nc1nncs1
NCc1ccc(F)nc1
O=C(N[Dy])c1ccc(Nc2nc(NCc3ccc(F)nc3)nc(Nc3nncs3)n2)c(Cl)c1
HSA
1
82,621,868
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(F)cn1
COC(=O)c1ccc(N)cc1O
COC(=O)c1ccc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3ccc(F)cn3)n2)cc1O
sEH
1
138,855,890
O=C(Nc1c(C(=O)O)ccc2ccccc12)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Cl.NCCCNC(=O)c1ccc(F)cc1
O=C(NCCCNc1nc(NCc2ccc(O)c3ncccc23)nc(Nc2c(C(=O)N[Dy])ccc3ccccc23)n1)c1ccc(F)cc1
sEH
1
82,038,638
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1c(Br)cncc1CN.Cl.Cl
Nc1ccc(-c2ncc[nH]2)cc1
Cc1c(Br)cncc1CNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2ccc(-c3ncc[nH]3)cc2)n1
sEH
1
65,156,979
N#Cc1ccc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Cl.NCc1ccc(-c2nnn[nH]2)cc1
N#Cc1ccc(C[C@@H](Nc2nc(NCc3ccc(-c4nnn[nH]4)cc3)nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])n2)C(=O)N[Dy])cc1
BRD4
1
231,834,421
O=C(Nc1ncc(C(=O)O)s1)OCC1c2ccccc2-c2ccccc21
Nc1cc(F)c(F)cc1[N+](=O)[O-]
CCOC(=O)c1ncccc1N
CCOC(=O)c1ncccc1Nc1nc(Nc2ncc(C(=O)N[Dy])s2)nc(Nc2cc(F)c(F)cc2[N+](=O)[O-])n1
HSA
1
155,394,989
O=C(Nc1c(OC(F)(F)F)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cn1cncc1C(CN)N1CCCC1
Nc1ccc2c(c1)CC(=O)N2
Cn1cncc1C(CNc1nc(Nc2ccc3c(c2)CC(=O)N3)nc(Nc2c(OC(F)(F)F)cccc2C(=O)N[Dy])n1)N1CCCC1
sEH
1
188,457,238
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Nc1nccc(-c2cccnc2)n1
Nc1n[nH]c2ccc([N+](=O)[O-])cc12
O=C(N[Dy])c1ccc(Nc2nc(Nc3nccc(-c4cccnc4)n3)nc(Nc3n[nH]c4ccc([N+](=O)[O-])cc34)n2)cc1
HSA
1
95,544,526
O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
NCC1CSCCN1Cc1ccccc1
O=C(N[Dy])[C@H](Cc1ccc(Cl)c(Cl)c1)Nc1nc(NCCC2CSC2)nc(NCC2CSCCN2Cc2ccccc2)n1
HSA
1
81,965,156
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1ccc(CN)c(C)c1OC
CC(C)(C)OC(=O)N1CCC(n2cc(N)cn2)CC1
COc1ccc(CNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3cnn(C4CCN(C(=O)OC(C)(C)C)CC4)c3)n2)c(C)c1OC
sEH
1
81,779,858
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC1(C)CCOC1CCN
Nc1nc2ccc(Cl)cc2s1
CC1(C)CCOC1CCNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2nc3ccc(Cl)cc3s2)n1
sEH
1
82,036,907
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1c(Br)cncc1CN.Cl.Cl
CC(C)(C)c1nnc(CN)s1.Cl
Cc1c(Br)cncc1CNc1nc(NCc2nnc(C(C)(C)C)s2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1
sEH
1
38,425,711
COc1cccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
COc1cncc(N)n1
Cl.NCCS(=O)(=O)Nc1ccccc1
COc1cncc(Nc2nc(NCCS(=O)(=O)Nc3ccccc3)nc(Nc3c(OC)cccc3C(=O)N[Dy])n2)n1
HSA
1
81,855,470
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CN1CC(CCN)CC1=O
Cl.NCC1CC12CCOCC2
CN1CC(CCNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NCC3CC34CCOCC4)n2)CC1=O
sEH
1
184,999,392
O=C(Nc1ccc(C(=O)O)c(Cl)c1)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
NCc1ccon1
O=C(N[Dy])c1ccc(Nc2nc(NCc3ccon3)nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])n2)cc1Cl
BRD4
1
81,937,619
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CO[C@@H]1COC[C@H]1n1cc(CN)nn1.Cl
Cc1cc(N)cc(Cl)c1
CO[C@@H]1COC[C@H]1n1cc(CNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3cc(C)cc(Cl)c3)n2)nn1
sEH
1
188,370,964
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Nc1cccc(CN2CCCCC2)c1
Cl.Nc1cccc2c(=O)cc(-c3nn[nH]n3)oc12
O=C(N[Dy])c1ccc(Nc2nc(Nc3cccc(CN4CCCCC4)c3)nc(Nc3cccc4c(=O)cc(-c5nn[nH]n5)oc34)n2)cc1
HSA
1
82,756,016
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1nc(NCc2ccc(F)cc2)ccc1[N+](=O)[O-]
Nc1ccc(N2CCOCC2)c(F)c1
O=C(N[Dy])C1CCC(CNc2nc(Nc3ccc(N4CCOCC4)c(F)c3)nc(Nc3nc(NCc4ccc(F)cc4)ccc3[N+](=O)[O-])n2)CC1
sEH
1
180,966,748
O=C(Nc1ccc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1ncccc1N
COc1cncc(N)n1
CCOC(=O)c1ncccc1Nc1nc(Nc2cncc(OC)n2)nc(Nc2ccc(Br)cc2C(=O)N[Dy])n1
HSA
1
285,011,850
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cocn1
COc1ncccc1N
COc1ncccc1Nc1nc(NCc2cocn2)nc(N2Cc3cc(O)ccc3C[C@H]2C(=O)N[Dy])n1
BRD4
1
253,780,931
O=C(O)C[C@@H](Cc1ccccc1Cl)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cncc(F)c1
CCSc1ccc(CN)cc1
CCSc1ccc(CNc2nc(Nc3cncc(F)c3)nc(N[C@@H](CC(=O)N[Dy])Cc3ccccc3Cl)n2)cc1
sEH
1
105,968,135
O=C(N[C@@H](Cc1cccs1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cncc(N)n1
Cl.Cl.Cn1cncc1CN
COc1cncc(Nc2nc(NCc3cncn3C)nc(N[C@@H](Cc3cccs3)C(=O)N[Dy])n2)n1
sEH
1
270,752,420
O=C(O)C[C@H](Cc1ccc(I)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CC2CC1C1CC21
COC(=O)c1cc(N)cc(F)c1
COC(=O)c1cc(F)cc(Nc2nc(NCC3CC4CC3C3CC43)nc(N[C@H](CC(=O)N[Dy])Cc3ccc(I)cc3)n2)c1
sEH
1
119,449,391
O=C(N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
N#Cc1cc(N)ccc1Cl
NCC1CCC(C(F)F)CC1
N#Cc1cc(Nc2nc(NCC3CCC(C(F)F)CC3)nc(N[C@H](Cc3ccc(-c4ccccc4)cc3)C(=O)N[Dy])n2)ccc1Cl
sEH
1
83,610,740
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1ccccc1CN1CCCC1=O
CC(CN)Cn1cccn1
CC(CNc1nc(NCc2ccccc2CN2CCCC2=O)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1)Cn1cccn1
sEH
1
93,865,591
O=C(N[C@@H](Cc1ccc(C(F)(F)F)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(N)ccc1C
Cc1cc2cc(CN)ccc2[nH]1
COC(=O)c1cc(Nc2nc(NCc3ccc4[nH]c(C)cc4c3)nc(N[C@@H](Cc3ccc(C(F)(F)F)cc3)C(=O)N[Dy])n2)ccc1C
HSA
1
82,603,541
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cl)cc1F
Cc1nc(CN)sc1C
Cc1nc(CNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3ccc(Cl)cc3F)n2)sc1C
sEH
1
249,070,699
O=C(O)C[C@@H](Cc1ccc(F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1nnc2ncccn12
Nc1ccc2nccnc2c1Br
O=C(C[C@@H](Cc1ccc(F)cc1)Nc1nc(NCc2nnc3ncccn23)nc(Nc2ccc3nccnc3c2Br)n1)N[Dy]
HSA
1
82,885,109
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCC#CCN
NCC1(Cc2ccccc2)CC1
CCC#CCNc1nc(NCC2(Cc3ccccc3)CC2)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
83,596,712
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1cc(-c2ccccc2)[nH]n1
NCc1ccccc1N1CCOCC1
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NCc3cc(-c4ccccc4)[nH]n3)nc(NCc3ccccc3N3CCOCC3)n2)CC1
sEH
1
81,844,538
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CN(C)C1(CN)CCSC1
CC(CN)Cn1cccn1
CC(CNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(NCC2(N(C)C)CCSC2)n1)Cn1cccn1
sEH
1
73,669,363
O=C(NC(CCc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1nnc2ncccn12
NCC1CN2CCN1CC2
O=C(N[Dy])C(CCc1ccccc1)Nc1nc(NCc2nnc3ncccn23)nc(NCC2CN3CCN2CC3)n1
HSA
1
195,086,714
O=C(Nc1ccc(C(=O)O)nc1)OCC1c2ccccc2-c2ccccc21
CC1(C)CC(CCN)C(=O)N1.Cl
Nc1nnn[nH]1
CC1(C)CC(CCNc2nc(Nc3ccc(C(=O)N[Dy])nc3)nc(Nc3nnn[nH]3)n2)C(=O)N1
sEH
1
192,406,223
O=C(Nc1ccc(C(=O)O)cc1O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Nc1ccc2ncoc2c1
O=C(N[Dy])c1ccc(Nc2nc(NCc3cnc4n3CCOC4)nc(Nc3ccc4ncoc4c3)n2)c(O)c1
sEH
1
81,927,554
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC1CCC(CCN)CC1
Cl.NCc1cc2ccccc2[nH]c1=O
COC1CCC(CCNc2nc(NCc3cc4ccccc4[nH]c3=O)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)CC1
sEH
1
286,112,090
O=C(O)[C@@H]1Cc2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1nnc(-c2ccncc2)[nH]1
COc1cncc(N)n1
COc1cncc(Nc2nc(NCc3nnc(-c4ccncc4)[nH]3)nc(N3Cc4ccccc4C[C@H]3C(=O)N[Dy])n2)n1
sEH
1
195,488,482
O=C(Nc1ccc(C(=O)O)nc1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC=Cc1cccnc1
CNC(=O)c1ccc(N)cc1F
CNC(=O)c1ccc(Nc2nc(NCC=Cc3cccnc3)nc(Nc3ccc(C(=O)N[Dy])nc3)n2)cc1F
HSA
1
51,660,491
Cc1cc(C)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
Cl.Cl.Cn1ccnc1Cn1c(CCCN)nc2c1CCCC2
COc1cncc(N)n1
COc1cncc(Nc2nc(NCCCc3nc4c(n3Cc3nccn3C)CCCC4)nc(Nc3c(C)cc(C)cc3C(=O)N[Dy])n2)n1
sEH
1
126,161,730
O=C(N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Nc1ccnc(Cl)c1
O=C(N[Dy])[C@@H](Cc1ccc([N+](=O)[O-])cc1)Nc1nc(Nc2ccnc(Cl)c2)nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])n1
BRD4
1
118,311,010
O=C(N[C@H](Cc1cc(F)cc(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Nc1ccc(F)c(C(F)(F)F)c1
O=C(N[Dy])[C@@H](Cc1cc(F)cc(F)c1)Nc1nc(NCc2cnc3n2CCOC3)nc(Nc2ccc(F)c(C(F)(F)F)c2)n1
HSA
1
82,553,123
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cc(Br)ccc1CO
Cl.NCc1cc(Br)no1
O=C(N[Dy])C1CCC(CNc2nc(NCc3cc(Br)no3)nc(Nc3cc(Br)ccc3CO)n2)CC1
sEH
1
69,769,958
N#Cc1cccc(C[C@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)c1
CC(C)(CN)CCC#N
NCC1CCC(C(F)F)CC1
CC(C)(CCC#N)CNc1nc(NCC2CCC(C(F)F)CC2)nc(N[C@@H](CC(=O)N[Dy])Cc2cccc(C#N)c2)n1
sEH
1
41,266,569
COc1nccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNC2=O
Cc1nnc(N)o1
COc1nccc(C(=O)N[Dy])c1Nc1nc(Nc2ccc3c(c2)CNC3=O)nc(Nc2nnc(C)o2)n1
BRD4
1
82,850,168
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(CN)Oc1ccc(Cl)cc1
Cc1[nH][nH]c(=O)c1CCN
Cc1[nH][nH]c(=O)c1CCNc1nc(NCC(C)Oc2ccc(Cl)cc2)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
47,913,715
Cc1cc(Br)c(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1nccc(Cl)n1
Nc1nc2ccc(Cl)cc2o1
Cc1cc(Br)c(C(=O)N[Dy])cc1Nc1nc(Nc2nccc(Cl)n2)nc(Nc2nc3ccc(Cl)cc3o2)n1
HSA
1
88,687,501
O=C(N[C@@H](CC1CC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1nnc(N)s1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(Nc4nnc(C)s4)nc(N[C@@H](CC4CC4)C(=O)N[Dy])n3)ccc2[nH]1
HSA
1
268,860,939
O=C(O)C[C@H](Cc1ccc(Cl)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)c(O)c(Cl)c1
N#Cc1ccsc1N
N#Cc1ccsc1Nc1nc(Nc2cc(Cl)c(O)c(Cl)c2)nc(N[C@H](CC(=O)N[Dy])Cc2ccc(Cl)cc2)n1
BRD4
1
67,478,958
N#Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Nc1cnc(Cl)cc1Cl
COc1ccc2nnc(CN)n2n1
COc1ccc2nnc(CNc3nc(Nc4cnc(Cl)cc4Cl)nc(N[C@@H](Cc4ccc(C#N)cc4)C(=O)N[Dy])n3)n2n1
BRD4
1
83,004,932
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(CN)C1CCOC1
Cl.NCc1ccsc1C(F)(F)F
COC(CNc1nc(NCc2ccsc2C(F)(F)F)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1)C1CCOC1
sEH
1
257,136,969
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Cl)cc1
CC(=O)c1ccc(N)c(F)c1
N#Cc1cnc2c(C#N)cnn2c1N
CC(=O)c1ccc(Nc2nc(Nc3c(C#N)cnc4c(C#N)cnn34)nc(N[C@H](CC(=O)N[Dy])c3ccc(Cl)cc3)n2)c(F)c1
BRD4
1
82,857,119
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(CN)c1c(Cl)cccc1Cl
Cl.NCC1CCCC1
CC(CNc1nc(NCC2CCCC2)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1)c1c(Cl)cccc1Cl
sEH
1
72,760,110
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)c(O)c(Cl)c1
Nc1ncnc2[nH]cnc12
O=C(N[Dy])C(CC1CCCCC1)Nc1nc(Nc2cc(Cl)c(O)c(Cl)c2)nc(Nc2ncnc3[nH]cnc23)n1
BRD4
1
167,642,636
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CCC2=O
Cl.Cl.NCc1cncc(F)c1
O=C(N[Dy])c1ccc(Cl)c(Nc2nc(NCc3cncc(F)c3)nc(Nc3ccc4c(c3)CCC4=O)n2)c1
sEH
1
200,961,185
O=C(Nc1ccc(F)c(C(=O)O)c1F)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Cc1ccc([N+](=O)[O-])c(N)n1
Cc1ccc([N+](=O)[O-])c(Nc2nc(NCc3ccc(O)c4ncccc34)nc(Nc3ccc(F)c(C(=O)N[Dy])c3F)n2)n1
sEH
1
83,175,629
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)on1
NCCC(=O)N1CCN(c2ccccn2)CC1
Cc1cc(Nc2nc(NCCC(=O)N3CCN(c4ccccn4)CC3)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)on1
sEH
1
18,418,927
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cccc2c(=O)[nH][nH]c(=O)c12
Nc1ccc2nccn2c1
CC(C)CC(Nc1nc(Nc2ccc3nccn3c2)nc(Nc2cccc3c(=O)[nH][nH]c(=O)c23)n1)C(=O)N[Dy]
HSA
1
3,787,948
C#CC[C@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ncc[nH]1
Nc1ncc(-c2ccccc2)s1
C#CC[C@H](CC(=O)N[Dy])Nc1nc(NCc2ncc[nH]2)nc(Nc2ncc(-c3ccccc3)s2)n1
HSA
1
179,328,391
O=C(Nc1cc2ccccc2cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
COc1cncc(N)c1
COc1cncc(Nc2nc(NCc3cnc4n3CCOC4)nc(Nc3cc4ccccc4cc3C(=O)N[Dy])n2)c1
HSA
1
167,117,752
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
Cc1csc(N)n1
Cn1c(=O)cc(N)[nH]c1=O
Cc1csc(Nc2nc(Nc3cc(=O)n(C)c(=O)[nH]3)nc(Nc3cc(C(=O)N[Dy])ccc3Cl)n2)n1
HSA
1
212,960,026
O=C(Nc1cccc(F)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Nc1nnc(S)s1
O=C(N[Dy])c1c(F)cccc1Nc1nc(NCc2cncc(F)c2)nc(Nc2nnc(S)s2)n1
HSA
1
18,307,200
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Cl.NCC1CCOC2(CCOCC2)C1
CC(C)CC(Nc1nc(NCC2CCOC3(CCOCC3)C2)nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])n1)C(=O)N[Dy]
BRD4
1
38,786,692
COc1cccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Nc1ccnc(Cl)c1
COc1cccc(C(=O)N[Dy])c1Nc1nc(NCc2cnc3n2CCOC3)nc(Nc2ccnc(Cl)c2)n1
HSA
1
81,823,142
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1ncccc1N
Nc1ccc(CC2COC(=O)N2)cc1
CCOC(=O)c1ncccc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2ccc(CC3COC(=O)N3)cc2)n1
sEH
1
179,328,739
O=C(Nc1cc2ccccc2cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Cc1nc(Cl)c(N)c(Cl)n1
Cc1nc(Cl)c(Nc2nc(NCc3cnc4n3CCOC4)nc(Nc3cc4ccccc4cc3C(=O)N[Dy])n2)c(Cl)n1
HSA
1
251,226,905
O=C(O)C[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cccc2cc[nH]c12
NCc1sncc1Br
O=C(C[C@@H](Cc1ccc([N+](=O)[O-])cc1)Nc1nc(NCc2sncc2Br)nc(NCc2cccc3cc[nH]c23)n1)N[Dy]
sEH
1
121,102,599
O=C(N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(N)ccc1Cl
CCC1=NN(Cc2ccccc2C)C(=O)C1CCN
CCC1=NN(Cc2ccccc2C)C(=O)C1CCNc1nc(Nc2ccc(Cl)c(C(=O)OC)c2)nc(N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[Dy])n1
BRD4
1
284,718,330
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)ccc1O
NCc1cn2cc(Cl)ccc2n1
Cc1cc(Nc2nc(NCc3cn4cc(Cl)ccc4n3)nc(N3Cc4cc(O)ccc4C[C@H]3C(=O)N[Dy])n2)ccc1O
BRD4
1