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pretty_name: DisProt Protein Disorder Annotations
license: cc-by-4.0
tags:
- biology
- proteins
- intrinsic-disorder
- disprot
- annotation
- parquet
configs:
- config_name: default
data_files:
- split: train
path: data/train-*.parquet
- split: test
path: data/test-*.parquet
---
# DisProt Protein Disorder Annotations
DisProt is a manually curated database of intrinsically disordered proteins and regions, including experimental evidence and functional annotations for protein disorder.
## Splits
The split is deterministic by DisProt ID: `sha256(disprot_id) % 10`. Bucket `0` is `test`; buckets `1` through `9` are `train`.
| Split | Rows |
|---|---:|
| train | 2,875 |
| test | 324 |
| total | 3,199 |
## Dataset Statistics
| Field | Value |
|---|---:|
| Protein entries | 3,199 |
| Curated region rows | 13,396 |
## Usage
```bash
pip install datasets
```
Load all splits:
```python
from datasets import load_dataset
ds = load_dataset("LiteFold/DisProt")
print(ds)
print(ds["train"][0]["disprot_id"])
```
Load one split:
```python
from datasets import load_dataset
train = load_dataset("LiteFold/DisProt", split="train")
```
Filter proteins with high disorder content:
```python
from datasets import load_dataset
ds = load_dataset("LiteFold/DisProt", split="train")
high_disorder = ds.filter(lambda row: row["disorder_content"] is not None and row["disorder_content"] >= 0.5)
print(high_disorder[0])
```
Load the region-level metadata:
```python
import pandas as pd
from huggingface_hub import hf_hub_download
path = hf_hub_download(
repo_id="LiteFold/DisProt",
repo_type="dataset",
filename="metadata/regions.parquet",
)
regions = pd.read_parquet(path)
print(regions.head())
```
## Key Columns
| Column | Description |
|---|---|
| `disprot_id` | DisProt protein identifier. |
| `accession` | UniProt accession. |
| `name` | Protein name. |
| `organism` | Organism name. |
| `ncbi_taxon_id` | NCBI taxonomy ID. |
| `length` | Protein sequence length. |
| `disorder_content` | Fraction of sequence annotated as disordered. |
| `dataset_labels` | DisProt dataset labels. |
| `sequence` | Protein sequence. |
| `region_count` | Number of curated region annotations. |
| `region_ids` | Curated region IDs. |
| `region_starts` | Region start positions. |
| `region_ends` | Region end positions. |
| `region_terms` | Region term names. |
| `evidence_codes` | Region evidence codes. |
| `reference_ids` | Region reference IDs. |
| `cross_refs` | Region cross-references such as PDB IDs. |
| `feature_databases` | Feature sources such as Pfam or Gene3D. |
| `feature_ids` | Feature IDs. |
| `gene_names` | Gene names and synonyms. |
| `split_bucket` | Deterministic split bucket from `sha256(disprot_id) % 10`. |
# Citation
```
@article{quaglia2022disprot,
title = {{DisProt} in 2022: improved quality and accessibility of protein intrinsic disorder annotation},
author = {Quaglia, Federica and M{\'e}sz{\'a}ros, B{\'a}lint and Salladini, Elisa and others},
journal = {Nucleic Acids Research},
volume = {50},
number = {D1},
pages = {D480--D487},
year = {2022},
doi = {10.1093/nar/gkab1082}
}
``` |