row_id string | dataset_id string | source_dataset string | source_file string | source_table string | source_sha string | row_index int64 | split string | subject_type string | entry_id int64 | sequence_id int64 | target_sequence_id int64 | source_sequence_length int64 | target_sequence_length int64 | protein_id int64 | protein_name string | organism string | isoform int64 | protein_ids string | protein_names string | organisms string | isoforms string | uniprot_accessions string | interpro_accessions string | ec_numbers string | megascale_ids string | other_references string | mutations string | substitutions string | deletions string | insertions string | mutation_count int64 | substitution_count int64 | deletion_count int64 | insertion_count int64 | first_position int64 | first_source_aa string | first_target_aa string | conservation float64 | feature_types string | pdb_ids string | afdb_ids string | structure_ids string | structure_methods string | structure_resolution_min float64 | residue_positions string | residue_chain_names string | residue_secondary_structures string | residue_in_pocket_any bool | residue_in_tunnel_any bool | residue_asa_mean float64 | residue_bfactor_mean float64 | experiment_id int64 | experiment_dataset string | ph float64 | measure string | method string | buffer string | buffer_conc string | exp_temperature float64 | ion string | ion_conc string | pdb_chain_mutation string | tm float64 | dtm float64 | dg float64 | dg_text string | ddg float64 | dh float64 | dcp float64 | dhvh float64 | cm float64 | m_value float64 | trypsin_ml float64 | chymotrypsin_ml float64 | stabilizing float64 | stabilizing_text string | domainome_fitness float64 | domainome_fitness_std float64 | domainome_ddg float64 | domainome_ddg_std float64 | reversibility string | state string | measurement_types string | measurement_datasets string | annotation_types string | publication_id string | publication_type string | publication_title string | publication_year int64 | publication_doi string | publication_pmid string | publication_journal string | publication_url string | publication_author_count int64 | publication_authors string | annotations_json string | measurements_json string | features_json string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
fireprotdb:1113 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,113 | train | mutant | 6,679 | 30 | 7,321 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | A47S | A47S | 1 | 1 | 0 | 0 | 47 | A | S | 4 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 47 | A | H | true | false | 61.153226 | 13.953 | 14,396 | ProTherm | 7 | CD | Urea | MOPS | 30 mM | 0 | 1RN1_A:A21S | null | null | null | 0.4 | null | null | null | 3.99 | 1.22 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 895 | ARTICLE | Helix propensities are identical in proteins and peptides. | 1,997 | 10.1021/bi9707180 | 9283083 | Biochemistry;36;10923-9 | 3 | Pace C N|Scholtz J M|Myers J K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":0.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"n... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":53201,"numValue":0.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":53202,"numValue":1.22,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":53203,"numValue":3.99,"references"... | [{"id":6494,"numValue":4.0,"position":47,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1114 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,114 | train | mutant | 6,680 | 30 | 7,322 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | A47T | A47T | 1 | 1 | 0 | 0 | 47 | A | T | 4 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 47 | A | H | true | false | 61.153226 | 13.953 | 14,388 | ProTherm | 2.5 | CD | Urea | glycine | 30 mM | 0 | 1RN1_A:A21T | null | null | null | 0.57 | null | null | null | 2.43 | 1.6 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 895 | ARTICLE | Helix propensities are identical in proteins and peptides. | 1,997 | 10.1021/bi9707180 | 9283083 | Biochemistry;36;10923-9 | 3 | Pace C N|Scholtz J M|Myers J K | [{"numValue":2.5,"strValue":null,"type":"PH"},{"numValue":0.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"glycine","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":53169,"numValue":0.57,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":53170,"numValue":1.6,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":53171,"numValue":2.43,"references"... | [{"id":6494,"numValue":4.0,"position":47,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1115 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,115 | train | mutant | 6,681 | 30 | 7,323 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | A47V | A47V | 1 | 1 | 0 | 0 | 47 | A | V | 4 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 47 | A | H | true | false | 61.153226 | 13.953 | 14,389 | ProTherm | 2.5 | CD | Urea | glycine | 30 mM | 0 | 1RN1_A:A21V | null | null | null | 0.66 | null | null | null | 2.38 | 1.77 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 895 | ARTICLE | Helix propensities are identical in proteins and peptides. | 1,997 | 10.1021/bi9707180 | 9283083 | Biochemistry;36;10923-9 | 3 | Pace C N|Scholtz J M|Myers J K | [{"numValue":2.5,"strValue":null,"type":"PH"},{"numValue":0.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"glycine","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":53173,"numValue":0.66,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":53174,"numValue":1.77,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":53175,"numValue":2.38,"references... | [{"id":6494,"numValue":4.0,"position":47,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1116 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,116 | train | mutant | 6,682 | 30 | 7,324 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | A47W | A47W | 1 | 1 | 0 | 0 | 47 | A | W | 4 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 47 | A | H | true | false | 61.153226 | 13.953 | 14,390 | ProTherm | 2.5 | CD | Urea | glycine | 30 mM | 0 | 1RN1_A:A21W | null | null | null | 0.3 | null | null | null | 2.6 | 1.56 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 895 | ARTICLE | Helix propensities are identical in proteins and peptides. | 1,997 | 10.1021/bi9707180 | 9283083 | Biochemistry;36;10923-9 | 3 | Pace C N|Scholtz J M|Myers J K | [{"numValue":2.5,"strValue":null,"type":"PH"},{"numValue":0.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"glycine","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":53177,"numValue":0.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":53178,"numValue":1.56,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":53179,"numValue":2.6,"references":... | [{"id":6494,"numValue":4.0,"position":47,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1117 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,117 | train | mutant | 6,683 | 30 | 7,325 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | A47Y | A47Y | 1 | 1 | 0 | 0 | 47 | A | Y | 4 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 47 | A | H | true | false | 61.153226 | 13.953 | 14,391 | ProTherm | 2.5 | CD | Urea | glycine | 30 mM | 0 | 1RN1_A:A21Y | null | null | null | 0.39 | null | null | null | 2.54 | 1.69 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 895 | ARTICLE | Helix propensities are identical in proteins and peptides. | 1,997 | 10.1021/bi9707180 | 9283083 | Biochemistry;36;10923-9 | 3 | Pace C N|Scholtz J M|Myers J K | [{"numValue":2.5,"strValue":null,"type":"PH"},{"numValue":0.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"glycine","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":53181,"numValue":0.39,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":53182,"numValue":1.69,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":53183,"numValue":2.54,"references... | [{"id":6494,"numValue":4.0,"position":47,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1118 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,118 | train | mutant | 7,139 | 30 | 7,794 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | A47G|G49A | A47G|G49A | 2 | 2 | 0 | 0 | 47 | A | G | 4 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 47|49 | A | H | true | false | 30.576613 | 12.870875 | 15,377 | ProTherm | 7.4 | Fluorescence | Urea | Sodium acetate | 50 mM | 25 | 1RN1_A:A21G 1RN1_A:G23A | null | null | 6 | null | null | null | null | 4.7 | 1.37 | null | null | null | null | null | null | null | yes | DG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 731 | ARTICLE | Hydrogen-exchange stabilities of RNase T1 and variants with buried and solvent-exposed Ala --> Gly mutations in the helix. | 1,999 | 10.1021/bi9919450 | 10600109 | Biochemistry;38;16481-90 | 4 | Steyaert J|Langhorst U|Pace C N|Huyghues-Despointes B M | [{"numValue":7.4,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"50 mM","typ... | [{"datasets":[],"id":56444,"numValue":6.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":56445,"numValue":1.37,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":56446,"numValue":4.7,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":56447,"numValue":null,"references":[],"st... | [{"id":6494,"numValue":4.0,"position":47,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6496,"numValue":9.0,"position":49,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:1120 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,120 | train | mutant | 30 | 30 | 32 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y50W | Y50W | 1 | 1 | 0 | 0 | 50 | Y | W | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 50 | A | H | true | false | 33.631191 | 11.895 | 30 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | null | Mops | 50 mM | 1RN1_A:Y24W | 58.8 | 1.6 | null | null | 106.12 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM, 2 mM","type":"BUFFER_CONC"},{"numValue":null,"strVal... | [{"datasets":[],"id":89,"numValue":58.8,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":90,"numValue":1.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":91,"numValue":106.12,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":92,"... | [{"id":6497,"numValue":6.0,"position":50,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1121 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,121 | train | mutant | 30 | 30 | 32 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y50W | Y50W | 1 | 1 | 0 | 0 | 50 | Y | W | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 50 | A | H | true | false | 33.631191 | 11.895 | 8,549 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:Y24W | null | null | null | -1.24 | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":29013,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","potapov_with_uniprot_mapping.csv"],"id":29014,"numValue":-1.24,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":29015,"numValue":null,"references":[]... | [{"id":6497,"numValue":6.0,"position":50,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1122 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,122 | train | mutant | 30 | 30 | 32 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y50W | Y50W | 1 | 1 | 0 | 0 | 50 | Y | W | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 50 | A | H | true | false | 33.631191 | 11.895 | 8,555 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:Y24W | null | null | 9.03 | null | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":29031,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":29032,"numValue":9.03,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":29033,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6497,"numValue":6.0,"position":50,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1123 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,123 | train | mutant | 6,692 | 30 | 7,334 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y50W|W85Y | Y50W|W85Y | 2 | 2 | 0 | 0 | 50 | Y | W | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 50|85 | A | H|E | true | false | 17.562769 | 11.28 | 14,433 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | null | Mops | 50 mM | 1RN1_A:Y24W 1RN1_A:W59Y | 56.6 | -0.6 | null | null | 100.62 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM, 2 mM","type":"BUFFER_CONC"},{"numValue":null,"strVal... | [{"datasets":[],"id":53362,"numValue":56.6,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":53363,"numValue":-0.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":53364,"numValue":100.62,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":53365,"numValue":null,"references":... | [{"id":6497,"numValue":6.0,"position":50,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1124 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,124 | train | mutant | 6,692 | 30 | 7,334 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y50W|W85Y | Y50W|W85Y | 2 | 2 | 0 | 0 | 50 | Y | W | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 50|85 | A | H|E | true | false | 17.562769 | 11.28 | 15,147 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:Y24W 1RN1_A:W59Y | null | null | null | -0.29 | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":55572,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55573,"numValue":-0.29,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55574,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6497,"numValue":6.0,"position":50,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1125 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,125 | train | mutant | 6,692 | 30 | 7,334 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y50W|W85Y | Y50W|W85Y | 2 | 2 | 0 | 0 | 50 | Y | W | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 50|85 | A | H|E | true | false | 17.562769 | 11.28 | 15,152 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:Y24W 1RN1_A:W59Y | null | null | 8.1 | null | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":55587,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55588,"numValue":8.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":55589,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6497,"numValue":6.0,"position":50,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1126 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,126 | train | mutant | 640 | 30 | 693 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Q51K | Q51K | 1 | 1 | 0 | 0 | 51 | Q | K | 3 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 51 | A | H | true | false | 105.524045 | 22.143889 | 1,057 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | null | 1RN1_A:Q25K | 51.7 | 3.4 | null | null | null | null | 107 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 109 | ARTICLE | Conformational stability and activity of ribonuclease T1 and mutants. Gln25----Lys, Glu58----Ala, and the double mutant. | 1,989 | 2663837 | J Biol Chem;264;11621-5 | 4 | Steyaert J|Stanssens P|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:Q25K","type"... | [{"datasets":[],"id":3948,"numValue":51.7,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3949,"numValue":3.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3950,"numValue":107.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"i... | [{"id":6498,"numValue":3.0,"position":51,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:1127 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,127 | train | mutant | 640 | 30 | 693 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Q51K | Q51K | 1 | 1 | 0 | 0 | 51 | Q | K | 3 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 51 | A | H | true | false | 105.524045 | 22.143889 | 3,013 | ProTherm | 5 | DSC | Thermal | Sodium borate-NaOH | 10 mM | null | NaCl | 80 mM | 1RN1_A:Q25K | 61.2 | 2.4 | null | null | 121.5 | 1.14 | 114.8 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|DCP|DHVH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 269 | ARTICLE | Energetics of ribonuclease T1 structure. | 1,994 | 10.1021/bi00177a023 | 8136367 | Biochemistry;33;3312-9 | 4 | Yu Y|Privalov P L|Pace C N|Makhatadze G I | [{"numValue":5.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium borate-NaOH","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10930,"numValue":61.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10931,"numValue":2.4,"references":[],"strValue":null... | [{"id":6498,"numValue":3.0,"position":51,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1128 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,128 | train | mutant | 640 | 30 | 693 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Q51K | Q51K | 1 | 1 | 0 | 0 | 51 | Q | K | 3 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 51 | A | H | true | false | 105.524045 | 22.143889 | 3,014 | ProTherm | 6 | DSC | Thermal | Sodium borate-NaOH | 10 mM | null | NaCl | 80 mM | 1RN1_A:Q25K | 56.9 | 2.8 | null | null | 112.4 | 0.99 | 110.5 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|DCP|DHVH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 269 | ARTICLE | Energetics of ribonuclease T1 structure. | 1,994 | 10.1021/bi00177a023 | 8136367 | Biochemistry;33;3312-9 | 4 | Yu Y|Privalov P L|Pace C N|Makhatadze G I | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium borate-NaOH","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10936,"numValue":56.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10937,"numValue":2.8,"references":[],"strValue":null... | [{"id":6498,"numValue":3.0,"position":51,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1129 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,129 | train | mutant | 640 | 30 | 693 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Q51K | Q51K | 1 | 1 | 0 | 0 | 51 | Q | K | 3 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 51 | A | H | true | false | 105.524045 | 22.143889 | 3,015 | ProTherm | 6.5 | DSC | Thermal | Sodium borate-NaOH | 10 mM | null | NaCl | 80 mM | 1RN1_A:Q25K | 54 | 2.9 | null | null | 109.3 | 1.19 | 108.6 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|DCP|DHVH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv|STRUM_Q3421.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 269 | ARTICLE | Energetics of ribonuclease T1 structure. | 1,994 | 10.1021/bi00177a023 | 8136367 | Biochemistry;33;3312-9 | 4 | Yu Y|Privalov P L|Pace C N|Makhatadze G I | [{"numValue":6.5,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium borate-NaOH","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":10942,"numValue":54.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10943,"numValue":2.9,"references":[],"strValue":null,"type":"DTM"},{"d... | [{"id":6498,"numValue":3.0,"position":51,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1131 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,131 | train | mutant | 640 | 30 | 693 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Q51K | Q51K | 1 | 1 | 0 | 0 | 51 | Q | K | 3 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 51 | A | H | true | false | 105.524045 | 22.143889 | 3,017 | ProTherm | 8.6 | DSC | Thermal | Sodium borate-NaOH | 10 mM | null | NaCl | 80 mM | 1RN1_A:Q25K | 46.6 | 3.2 | null | null | 97.6 | 1.15 | 102.2 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|DCP|DHVH|REVERSIBILITY | AUTOMUTE_S1925.csv|EASE-MM_S1676.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|M47andM8_S2760.csv|PON-TStab_dataset.csv|STRUM_Q3421.csv|SVM-WIN31_SVM-3D12_S1634.csv|SVM-WIN31_SVM-3D12_S1681.csv|AUTOMUTE_S1749.csv|iPTREE-STAB_S1859.csv|Saraboji_S1791.csv|M47andM8_S1810.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 269 | ARTICLE | Energetics of ribonuclease T1 structure. | 1,994 | 10.1021/bi00177a023 | 8136367 | Biochemistry;33;3312-9 | 4 | Yu Y|Privalov P L|Pace C N|Makhatadze G I | [{"numValue":8.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium borate-NaOH","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"... | [{"datasets":["AUTOMUTE_S1925.csv","EASE-MM_S1676.csv","I_Mutant2.0_S1948.csv","I_Mutant2.0_S2087.csv","M47andM8_S2760.csv","PON-TStab_dataset.csv","STRUM_Q3421.csv","SVM-WIN31_SVM-3D12_S1634.csv","SVM-WIN31_SVM-3D12_S1681.csv"],"id":10954,"numValue":46.6,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOM... | [{"id":6498,"numValue":3.0,"position":51,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1132 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,132 | train | mutant | 640 | 30 | 693 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Q51K | Q51K | 1 | 1 | 0 | 0 | 51 | Q | K | 3 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 51 | A | H | true | false | 105.524045 | 22.143889 | 3,018 | ProTherm | 9.7 | DSC | Thermal | Sodium borate-NaOH | 10 mM | null | NaCl | 80 mM | 1RN1_A:Q25K | 44 | 3.3 | null | null | 94 | 1.38 | 105 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|DCP|DHVH|REVERSIBILITY | AUTOMUTE_S1925.csv|EASE-MM_S1676.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|M47andM8_S2760.csv|PON-TStab_dataset.csv|STRUM_Q3421.csv|SVM-WIN31_SVM-3D12_S1634.csv|SVM-WIN31_SVM-3D12_S1681.csv|AUTOMUTE_S1749.csv|iPTREE-STAB_S1859.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 269 | ARTICLE | Energetics of ribonuclease T1 structure. | 1,994 | 10.1021/bi00177a023 | 8136367 | Biochemistry;33;3312-9 | 4 | Yu Y|Privalov P L|Pace C N|Makhatadze G I | [{"numValue":9.7,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium borate-NaOH","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"... | [{"datasets":["AUTOMUTE_S1925.csv","EASE-MM_S1676.csv","I_Mutant2.0_S1948.csv","I_Mutant2.0_S2087.csv","M47andM8_S2760.csv","PON-TStab_dataset.csv","STRUM_Q3421.csv","SVM-WIN31_SVM-3D12_S1634.csv","SVM-WIN31_SVM-3D12_S1681.csv"],"id":10960,"numValue":44.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOM... | [{"id":6498,"numValue":3.0,"position":51,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1133 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,133 | train | mutant | 640 | 30 | 693 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Q51K | Q51K | 1 | 1 | 0 | 0 | 51 | Q | K | 3 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 51 | A | H | true | false | 105.524045 | 22.143889 | 7,759 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | 48.6 | 1RN1_A:Q25K | null | null | null | -0.93 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 109 | ARTICLE | Conformational stability and activity of ribonuclease T1 and mutants. Gln25----Lys, Glu58----Ala, and the double mutant. | 1,989 | 2663837 | J Biol Chem;264;11621-5 | 4 | Steyaert J|Stanssens P|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":48.6,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUF... | [{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","potapov_with_uniprot_mapping.csv"],"id":26643,"numValue":-0.93,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26644,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":6498,"numValue":3.0,"position":51,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:1134 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,134 | train | mutant | 640 | 30 | 693 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Q51K | Q51K | 1 | 1 | 0 | 0 | 51 | Q | K | 3 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 51 | A | H | true | false | 105.524045 | 22.143889 | 8,891 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30 mM | 25 | 1RN1_A:Q25K | null | null | 6.39 | -0.77 | null | null | null | 5.3 | 1.21 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 109 | ARTICLE | Conformational stability and activity of ribonuclease T1 and mutants. Gln25----Lys, Glu58----Ala, and the double mutant. | 1,989 | 2663837 | J Biol Chem;264;11621-5 | 4 | Steyaert J|Stanssens P|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":[],"id":30130,"numValue":6.39,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":30131,"numValue":-0.77,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30132,"numValue":1.21,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":30133,"numValue":5.... | [{"id":6498,"numValue":3.0,"position":51,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:1135 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,135 | train | mutant | 6,799 | 30 | 7,441 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Q51K|E84A | Q51K|E84A | 2 | 2 | 0 | 0 | 51 | Q | K | 3 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 51|84 | A | H|E | true | true | 58.979321 | 18.800555 | 14,596 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | null | 1RN1_A:Q25K 1RN1_A:E58A | 48.8 | -0.5 | null | null | null | null | 93 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 109 | ARTICLE | Conformational stability and activity of ribonuclease T1 and mutants. Gln25----Lys, Glu58----Ala, and the double mutant. | 1,989 | 2663837 | J Biol Chem;264;11621-5 | 4 | Steyaert J|Stanssens P|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:Q25K 1RN1_A:... | [{"datasets":[],"id":53972,"numValue":48.8,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":53973,"numValue":-0.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":53974,"numValue":93.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":53975,"numValue":null,"references":... | [{"id":4,"numValue":null,"position":84,"positionArray":null,"positionRange":null,"strValue":"Proton acceptor","type":"ACTIVE_SITE"},{"id":6498,"numValue":3.0,"position":51,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6531,"numValue":9.0,"position":84,"positionArray":null,"posit... | ||||||||||||||
fireprotdb:1136 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,136 | train | mutant | 6,799 | 30 | 7,441 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Q51K|E84A | Q51K|E84A | 2 | 2 | 0 | 0 | 51 | Q | K | 3 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 51|84 | A | H|E | true | true | 58.979321 | 18.800555 | 15,060 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | 48.6 | 1RN1_A:Q25K 1RN1_A:E58A | null | null | null | -0.06 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 109 | ARTICLE | Conformational stability and activity of ribonuclease T1 and mutants. Gln25----Lys, Glu58----Ala, and the double mutant. | 1,989 | 2663837 | J Biol Chem;264;11621-5 | 4 | Steyaert J|Stanssens P|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":48.6,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUF... | [{"datasets":[],"id":55311,"numValue":-0.06,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55312,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":4,"numValue":null,"position":84,"positionArray":null,"positionRange":null,"strValue":"Proton acceptor","type":"ACTIVE_SITE"},{"id":6498,"numValue":3.0,"position":51,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6531,"numValue":9.0,"position":84,"positionArray":null,"posit... | ||||||||||||||
fireprotdb:1138 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,138 | train | mutant | 651 | 30 | 704 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N62A | N62A | 1 | 1 | 0 | 0 | 62 | N | A | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 62 | A | T | false | true | 81.591732 | 27.28375 | 1,068 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | null | 1RN1_A:N36A | 50.9 | 0 | null | null | null | null | 111 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DHVH|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:N36A","type"... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":3992,"numValue":50.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","Saraboji_S1791.csv"],"id":3993,"numValue":0.0,"references":[],"strValue":null,"type... | [{"id":6509,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1139 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,139 | train | mutant | 651 | 30 | 704 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N62A | N62A | 1 | 1 | 0 | 0 | 62 | N | A | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 62 | A | T | false | true | 81.591732 | 27.28375 | 7,632 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | 50.9 | 1RN1_A:N36A | null | null | null | 0 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":50.9,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUF... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv"],"id":26329,"numValue":0.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":26330,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY... | [{"id":6509,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1140 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,140 | train | mutant | 651 | 30 | 704 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N62A | N62A | 1 | 1 | 0 | 0 | 62 | N | A | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 62 | A | T | false | true | 81.591732 | 27.28375 | 8,902 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30 mM | 25 | 1RN1_A:N36A | null | null | null | -0.03 | null | null | null | 5.31 | 1.31 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":30176,"numValue":-0.03,"references":[],"strValue":null,"type":"DDG"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":30177,"numValu... | [{"id":6509,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1141 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,141 | train | mutant | 4,346 | 30 | 4,856 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | P65A | P65A | 1 | 1 | 0 | 0 | 65 | P | A | 9 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 65 | A | S | true | false | 9.467264 | 11.424286 | 10,300 | ProTherm | 5 | Fluorescence | GdnHCl | Sodium acetate | 0.1 M | 25 | 1RN1_A:P39A | null | null | 4.88 | 5.12 | null | null | null | 1.71 | 2.63 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 670 | ARTICLE | Stability and folding kinetics of ribonuclease T1 are strongly altered by the replacement of cis-proline 39 with alanine. | 1,993 | 10.1006/jmbi.1993.1336 | 8515459 | J Mol Biol;231;897-912 | 4 | Hahn U|Landt O|Schmid F X|Mayr L M | [{"numValue":5.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","t... | [{"datasets":[],"id":35309,"numValue":4.88,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":35310,"numValue":5.12,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":35311,"numValue":2.63,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":35312,"numValue":1.71,"references":[],... | [{"id":6512,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:1143 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,143 | train | mutant | 4,346 | 30 | 4,856 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | P65A | P65A | 1 | 1 | 0 | 0 | 65 | P | A | 9 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 65 | A | S | true | false | 9.467264 | 11.424286 | 14,000 | ProTherm | 8 | Fluorescence | GdnHCl | Tris | 0.1 M | 10 | 1RN1_A:P39A | null | null | 4.11 | 4.33 | null | null | null | 1.43 | 2.87 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 670 | ARTICLE | Stability and folding kinetics of ribonuclease T1 are strongly altered by the replacement of cis-proline 39 with alanine. | 1,993 | 10.1006/jmbi.1993.1336 | 8515459 | J Mol Biol;231;897-912 | 4 | Hahn U|Landt O|Schmid F X|Mayr L M | [{"numValue":8.0,"strValue":null,"type":"PH"},{"numValue":10.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Tris","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","type":"BUFF... | [{"datasets":[],"id":51856,"numValue":4.11,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv"],"id":51857,"numValue":4.33,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":51858,"numValue":2.87,"references":[],"strValue":null,"type":"M"},{"... | [{"id":6512,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1144 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,144 | train | mutant | 33 | 30 | 35 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | H66T | H66T | 1 | 1 | 0 | 0 | 66 | H | T | 9 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 66 | A | E | true | true | 62.29325 | 13.775 | 33 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | null | Mops | 50 mM | 1RN1_A:H40T | 56.7 | -0.5 | null | null | 100.14 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM, 2 mM","type":"BUFFER_CONC"},{"numValue":null,"strVal... | [{"datasets":[],"id":101,"numValue":56.7,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":102,"numValue":-0.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":103,"numValue":100.14,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":... | [{"id":3,"numValue":null,"position":66,"positionArray":null,"positionRange":null,"strValue":null,"type":"ACTIVE_SITE"},{"id":6513,"numValue":9.0,"position":66,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1145 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,145 | train | mutant | 33 | 30 | 35 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | H66T | H66T | 1 | 1 | 0 | 0 | 66 | H | T | 9 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 66 | A | E | true | true | 62.29325 | 13.775 | 8,552 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:H40T | null | null | null | 0.26 | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":29022,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":29023,"numValue":0.26,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":29024,... | [{"id":3,"numValue":null,"position":66,"positionArray":null,"positionRange":null,"strValue":null,"type":"ACTIVE_SITE"},{"id":6513,"numValue":9.0,"position":66,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1147 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,147 | train | mutant | 6,695 | 30 | 7,337 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | H66T|W85Y | H66T|W85Y | 2 | 2 | 0 | 0 | 66 | H | T | 9 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 66|85 | A | E | true | true | 31.893799 | 12.22 | 14,436 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | null | Mops | 50 mM | 1RN1_A:H40T 1RN1_A:W59Y | 53.9 | -3.3 | null | null | 92.5 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM, 2 mM","type":"BUFFER_CONC"},{"numValue":null,"strVal... | [{"datasets":[],"id":53374,"numValue":53.9,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":53375,"numValue":-3.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":53376,"numValue":92.5,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":53377,"numValue":null,"references":[]... | [{"id":3,"numValue":null,"position":66,"positionArray":null,"positionRange":null,"strValue":null,"type":"ACTIVE_SITE"},{"id":6513,"numValue":9.0,"position":66,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":nul... | |||||||||||
fireprotdb:1148 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,148 | train | mutant | 6,695 | 30 | 7,337 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | H66T|W85Y | H66T|W85Y | 2 | 2 | 0 | 0 | 66 | H | T | 9 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 66|85 | A | E | true | true | 31.893799 | 12.22 | 15,150 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:H40T 1RN1_A:W59Y | null | null | null | 0.93 | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":55581,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55582,"numValue":0.93,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55583,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":3,"numValue":null,"position":66,"positionArray":null,"positionRange":null,"strValue":null,"type":"ACTIVE_SITE"},{"id":6513,"numValue":9.0,"position":66,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":nul... | |||||||||||
fireprotdb:1149 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,149 | train | mutant | 6,695 | 30 | 7,337 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | H66T|W85Y | H66T|W85Y | 2 | 2 | 0 | 0 | 66 | H | T | 9 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 66|85 | A | E | true | true | 31.893799 | 12.22 | 15,155 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:H40T 1RN1_A:W59Y | null | null | 6.88 | null | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":55596,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55597,"numValue":6.88,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":55598,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":3,"numValue":null,"position":66,"positionArray":null,"positionRange":null,"strValue":null,"type":"ACTIVE_SITE"},{"id":6513,"numValue":9.0,"position":66,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":nul... | |||||||||||
fireprotdb:1150 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,150 | train | mutant | 31 | 30 | 33 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y68W | Y68W | 1 | 1 | 0 | 0 | 68 | Y | W | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 68 | A | L|E | true | true | 13.303211 | 14.945417 | 31 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | null | Mops | 50 mM | 1RN1_A:Y42W | 56.6 | -0.6 | null | null | 96.08 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM, 2 mM","type":"BUFFER_CONC"},{"numValue":null,"strVal... | [{"datasets":[],"id":93,"numValue":56.6,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":94,"numValue":-0.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":95,"numValue":96.08,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":96,"... | [{"id":6515,"numValue":8.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1151 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,151 | train | mutant | 31 | 30 | 33 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y68W | Y68W | 1 | 1 | 0 | 0 | 68 | Y | W | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 68 | A | L|E | true | true | 13.303211 | 14.945417 | 8,550 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:Y42W | null | null | null | 0.14 | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":29016,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":29017,"numValue":0.14,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":29018,... | [{"id":6515,"numValue":8.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1152 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,152 | train | mutant | 31 | 30 | 33 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y68W | Y68W | 1 | 1 | 0 | 0 | 68 | Y | W | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 68 | A | L|E | true | true | 13.303211 | 14.945417 | 8,556 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:Y42W | null | null | 7.67 | null | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":29034,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":29035,"numValue":7.67,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":29036,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6515,"numValue":8.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1153 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,153 | train | mutant | 643 | 30 | 696 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y68F | Y68F | 1 | 1 | 0 | 0 | 68 | Y | F | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 68 | A | L|E | true | true | 13.303211 | 14.945417 | 1,060 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | null | 1RN1_A:Y42F | 54.3 | 3.4 | null | null | null | null | 106 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:Y42F","type"... | [{"datasets":[],"id":3960,"numValue":54.3,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3961,"numValue":3.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3962,"numValue":106.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"i... | [{"id":6515,"numValue":8.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1154 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,154 | train | mutant | 643 | 30 | 696 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y68F | Y68F | 1 | 1 | 0 | 0 | 68 | Y | F | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 68 | A | L|E | true | true | 13.303211 | 14.945417 | 7,624 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | 50.9 | 1RN1_A:Y42F | null | null | null | -1.15 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | capriotti_S1615_map.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":50.9,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUF... | [{"datasets":["capriotti_S1615_map.csv"],"id":26313,"numValue":-1.15,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26314,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6515,"numValue":8.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1155 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,155 | train | mutant | 643 | 30 | 696 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y68F | Y68F | 1 | 1 | 0 | 0 | 68 | Y | F | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 68 | A | L|E | true | true | 13.303211 | 14.945417 | 8,894 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30 mM | 25 | 1RN1_A:Y42F | null | null | null | -1.14 | null | null | null | 6.24 | 1.17 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":30144,"numValue":-1.14,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30145,"numValue":1.17,"references":[],"strValue":null,"type":"M"},{"dat... | [{"id":6515,"numValue":8.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1156 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,156 | train | mutant | 6,693 | 30 | 7,335 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y68W|W85Y | Y68W|W85Y | 2 | 2 | 0 | 0 | 68 | Y | W | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 68|85 | A | L|E | true | true | 7.39878 | 12.805208 | 14,434 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | null | Mops | 50 mM | 1RN1_A:Y42W 1RN1_A:W59Y | 53.7 | -3.5 | null | null | 91.78 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM, 2 mM","type":"BUFFER_CONC"},{"numValue":null,"strVal... | [{"datasets":[],"id":53366,"numValue":53.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":53367,"numValue":-3.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":53368,"numValue":91.78,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":53369,"numValue":null,"references":[... | [{"id":6515,"numValue":8.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1157 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,157 | train | mutant | 6,693 | 30 | 7,335 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y68W|W85Y | Y68W|W85Y | 2 | 2 | 0 | 0 | 68 | Y | W | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 68|85 | A | L|E | true | true | 7.39878 | 12.805208 | 15,148 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:Y42W 1RN1_A:W59Y | null | null | null | 1.03 | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":55575,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55576,"numValue":1.03,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55577,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6515,"numValue":8.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1158 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,158 | train | mutant | 6,693 | 30 | 7,335 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y68W|W85Y | Y68W|W85Y | 2 | 2 | 0 | 0 | 68 | Y | W | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 68|85 | A | L|E | true | true | 7.39878 | 12.805208 | 15,153 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:Y42W 1RN1_A:W59Y | null | null | 6.76 | null | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":55590,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55591,"numValue":6.76,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":55592,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6515,"numValue":8.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1160 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,160 | train | mutant | 652 | 30 | 705 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70A | N70A | 1 | 1 | 0 | 0 | 70 | N | A | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 1,098 | ProTherm | 7 | CD | Thermal | MOPS | 30 mM | null | 1RN1_A:N44A | 45.6 | -5.2 | null | null | null | null | 86.8 | null | null | null | null | null | null | null | null | null | Yes | 2.0 | TM|DTM|DHVH|STATE|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv|HotMuSiC_S1626.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:N44A","type":"_PDB_CHA... | [{"datasets":[],"id":4111,"numValue":45.6,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":4112,"numValue":-5.2,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":4113,"numValue":86.8,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"i... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1161 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,161 | train | mutant | 652 | 30 | 705 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70A | N70A | 1 | 1 | 0 | 0 | 70 | N | A | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 3,309 | ProTherm | 7 | CD | Thermal | MOPS | 30 mM | null | 1RN1_A:N44A | 45.6 | -5.2 | null | null | null | null | 86.8 | null | null | null | null | null | null | null | null | null | yes (>95%) | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:N44A","type":"_PDB_CHA... | [{"datasets":[],"id":12176,"numValue":45.6,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":12177,"numValue":-5.2,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":12178,"numValue":86.8,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[]... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1163 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,163 | train | mutant | 652 | 30 | 705 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70A | N70A | 1 | 1 | 0 | 0 | 70 | N | A | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 7,637 | ProTherm | 7 | CD | Thermal | MOPS | 30 mM | 50.8 | 1RN1_A:N44A | null | null | null | 1.6 | null | null | null | null | null | null | null | null | null | null | null | null | yes (>95%) | DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":50.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"}... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":26339,"numValue":1.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26340,"numValue":null,"references":[],"strValue":"yes (>95%)","type":"REVERSIBILITY"}] | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1164 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,164 | train | mutant | 652 | 30 | 705 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70A | N70A | 1 | 1 | 0 | 0 | 70 | N | A | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 8,903 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30 mM | 25 | 1RN1_A:N44A | null | null | null | 2.08 | null | null | null | 3.59 | 1.3 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv"],"id":30180,"numValue":2.08,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30181,"numValue":1.3,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":30182,"numValue":3.59,"references":[],"strValue":null,"type":"CM"},{"dataset... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1165 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,165 | train | mutant | 652 | 30 | 705 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70A | N70A | 1 | 1 | 0 | 0 | 70 | N | A | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 8,914 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30 mM | 25 | 1RN1_A:N44A | null | null | 4.12 | 2 | null | null | null | 3.51 | 1.17 | null | null | null | null | null | null | null | Yes | 2.0 | DG|DDG|M|CM|STATE|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":[],"id":30235,"numValue":4.12,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":30236,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30237,"numValue":1.17,"references":[],"strValue":n... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1166 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,166 | train | mutant | 652 | 30 | 705 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70A | N70A | 1 | 1 | 0 | 0 | 70 | N | A | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 10,697 | ProTherm | 7 | CD | Urea | MOPS | 30 mM | 25 | 1RN1_A:N44A | null | null | 4.12 | 2 | null | null | null | 3.51 | 1.17 | null | null | null | null | null | null | null | yes (>95%) | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"... | [{"datasets":[],"id":36722,"numValue":4.12,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":36723,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":36724,"numValue":1.17,"references":[],"strValue":n... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1168 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,168 | train | mutant | 668 | 30 | 724 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70D | N70D | 1 | 1 | 0 | 0 | 70 | N | D | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 3,307 | ProTherm | 7 | CD | Thermal | MOPS | 30 mM | null | 1RN1_A:N44D | 45.3 | -5.5 | null | null | null | null | 84.2 | null | null | null | null | null | null | null | null | null | yes (>95%) | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:N44D","type":"_PDB_CHA... | [{"datasets":[],"id":12168,"numValue":45.3,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":12169,"numValue":-5.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":12170,"numValue":84.2,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[]... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1169 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,169 | train | mutant | 668 | 30 | 724 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70D | N70D | 1 | 1 | 0 | 0 | 70 | N | D | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 7,635 | ProTherm | 7 | CD | Thermal | MOPS | 30 mM | 50.8 | 1RN1_A:N44D | null | null | null | 1.6 | null | null | null | null | null | null | null | null | null | null | null | null | yes (>95%) | DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":50.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"}... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":26335,"numValue":1.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26336,"numValue":null,"references":[],"strValue":"yes (>95%)","type":"REVERSIBILITY"}] | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1170 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,170 | train | mutant | 668 | 30 | 724 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70D | N70D | 1 | 1 | 0 | 0 | 70 | N | D | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 8,912 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30 mM | 25 | 1RN1_A:N44D | null | null | 4.43 | 2 | null | null | null | 3.54 | 1.25 | null | null | null | null | null | null | null | Yes | 2.0 | DG|DDG|M|CM|STATE|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":[],"id":30223,"numValue":4.43,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv"],"id":30224,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30225,"numValue":1.25,"references":[],"strValue":null,"type":"M"},{"d... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1171 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,171 | train | mutant | 668 | 30 | 724 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70D | N70D | 1 | 1 | 0 | 0 | 70 | N | D | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 8,915 | ProTherm | 2.7 | Fluorescence | Urea | glycine | 30 mM | 25 | 1RN1_A:N44D | null | null | 5.71 | null | null | null | null | 3.45 | 1.66 | null | null | null | null | null | null | null | Yes | 2.0 | DG|M|CM|STATE|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":2.7,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"glycine","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUF... | [{"datasets":[],"id":30241,"numValue":5.71,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":30242,"numValue":1.66,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":30243,"numValue":3.45,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":30244,"numValue":2.0,"references":[],"s... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1172 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,172 | train | mutant | 668 | 30 | 724 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70D | N70D | 1 | 1 | 0 | 0 | 70 | N | D | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 10,695 | ProTherm | 7 | CD | Urea | MOPS | 30 mM | 25 | 1RN1_A:N44D | null | null | 4.43 | 2 | null | null | null | 3.54 | 1.25 | null | null | null | null | null | null | null | yes (>95%) | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"... | [{"datasets":[],"id":36712,"numValue":4.43,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv"],"id":36713,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":36714,"numValue":1.25,"references":[],"strValue":null,"type":"M"},{"d... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1173 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,173 | train | mutant | 668 | 30 | 724 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70D | N70D | 1 | 1 | 0 | 0 | 70 | N | D | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 10,698 | ProTherm | 2.7 | CD | Urea | glycine | 30 mM | 25 | 1RN1_A:N44D | null | null | 5.71 | 0.5 | null | null | null | 3.45 | 1.66 | null | null | null | null | null | null | null | yes (>95%) | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":2.7,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"glycine","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"}... | [{"datasets":[],"id":36727,"numValue":5.71,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":36728,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":36729,"numValue":1.66,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":36730,"numValue":3.45,"references":[],"... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:1174 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,174 | train | mutant | 669 | 30 | 725 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70S | N70S | 1 | 1 | 0 | 0 | 70 | N | S | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 1,097 | ProTherm | 7 | CD | Thermal | MOPS | 30 mM | null | 1RN1_A:N44S | 45.8 | -5 | null | null | null | null | 89.6 | null | null | null | null | null | null | null | null | null | Yes | 2.0 | TM|DTM|DHVH|STATE|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:N44S","type":"_PDB_CHA... | [{"datasets":[],"id":4106,"numValue":45.8,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":4107,"numValue":-5.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":4108,"numValue":89.6,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"i... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1175 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,175 | train | mutant | 669 | 30 | 725 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70S | N70S | 1 | 1 | 0 | 0 | 70 | N | S | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 3,308 | ProTherm | 7 | CD | Thermal | MOPS | 30 mM | null | 1RN1_A:N44S | 45.8 | -5 | null | null | null | null | 89.6 | null | null | null | null | null | null | null | null | null | yes (>95%) | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:N44S","type":"_PDB_CHA... | [{"datasets":[],"id":12172,"numValue":45.8,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":12173,"numValue":-5.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":12174,"numValue":89.6,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[]... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1176 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,176 | train | mutant | 669 | 30 | 725 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70S | N70S | 1 | 1 | 0 | 0 | 70 | N | S | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 7,636 | ProTherm | 7 | CD | Thermal | MOPS | 30 mM | 50.8 | 1RN1_A:N44S | null | null | null | 1.5 | null | null | null | null | null | null | null | null | null | null | null | null | yes (>95%) | DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":50.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"}... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":26337,"numValue":1.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26338,"numValue":null,"references":[],"strValue":"yes (>95%)","type":"REVERSIBILITY"}] | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1177 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,177 | train | mutant | 669 | 30 | 725 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70S | N70S | 1 | 1 | 0 | 0 | 70 | N | S | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 8,913 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30 mM | 25 | 1RN1_A:N44S | null | null | 4.39 | 1.9 | null | null | null | 3.6 | 1.22 | null | null | null | null | null | null | null | Yes | 2.0 | DG|DDG|M|CM|STATE|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":[],"id":30229,"numValue":4.39,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":30230,"numValue":1.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30231,"numValue":1.22,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":30232,"numValue":3.6,... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1178 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,178 | train | mutant | 669 | 30 | 725 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | N70S | N70S | 1 | 1 | 0 | 0 | 70 | N | S | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 70 | A | L | true | true | 37.443961 | 14.67375 | 10,696 | ProTherm | 7 | CD | Urea | MOPS | 30 mM | 25 | 1RN1_A:N44S | null | null | 4.39 | 1.9 | null | null | null | 3.6 | 1.22 | null | null | null | null | null | null | null | yes (>95%) | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 114 | ARTICLE | Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1. | 1,998 | 10.1021/bi9815243 | 9819211 | Biochemistry;37;16192-200 | 7 | Giletto A|Sevcik J|Urbanikova L|Dauter Z|Pace C N|Hebert E J|Wilson K S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"... | [{"datasets":[],"id":36717,"numValue":4.39,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":36718,"numValue":1.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":36719,"numValue":1.22,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":36720,"numValue":3.6,... | [{"id":6517,"numValue":8.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1179 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,179 | train | mutant | 32 | 30 | 34 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y71W | Y71W | 1 | 1 | 0 | 0 | 71 | Y | W | 5 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 71 | A | L|T | true | true | 165.428457 | 23.737954 | 32 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | null | Mops | 50 mM | 1RN1_B:Y45W | 55.9 | -1.3 | null | null | 106.84 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM, 2 mM","type":"BUFFER_CONC"},{"numValue":null,"strVal... | [{"datasets":[],"id":97,"numValue":55.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":98,"numValue":-1.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":99,"numValue":106.84,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":100... | [{"id":6518,"numValue":5.0,"position":71,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1180 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,180 | train | mutant | 32 | 30 | 34 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y71W | Y71W | 1 | 1 | 0 | 0 | 71 | Y | W | 5 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 71 | A | L|T | true | true | 165.428457 | 23.737954 | 2,917 | ProTherm | 7 | Absorbance | Thermal | Sodium cacodylate | 10 mM | null | 1RN1_B:Y45W | 56 | -1.6 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 255 | ARTICLE | Impact of point mutations on the structure and thermal stability of ribonuclease T1 in aqueous solution probed by Fourier transform infrared spectroscopy. | 1,994 | 10.1021/bi00201a021 | 8075073 | Biochemistry;33;10725-30 | 7 | Backmann J|Fabian H|Schultz C|Hahn U|Saenger W|Naumann D|Mantsch H H | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Absorbance","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium cacodylate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_B:Y... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10580,"numValue":56.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10581,"numValue":-1.6,"references":[],"strValue":nul... | [{"id":6518,"numValue":5.0,"position":71,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1181 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,181 | train | mutant | 32 | 30 | 34 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y71W | Y71W | 1 | 1 | 0 | 0 | 71 | Y | W | 5 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 71 | A | L|T | true | true | 165.428457 | 23.737954 | 8,551 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_B:Y45W | null | null | null | -0.74 | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|khan_protherm_data_mapped.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":29019,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","khan_protherm_data_mapped.csv"],"id":29020,"numValue":-0.74,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":29021,"numValue":null,"references":[],"s... | [{"id":6518,"numValue":5.0,"position":71,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1182 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,182 | train | mutant | 32 | 30 | 34 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y71W | Y71W | 1 | 1 | 0 | 0 | 71 | Y | W | 5 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 71 | A | L|T | true | true | 165.428457 | 23.737954 | 8,557 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_B:Y45W | null | null | 8.56 | null | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":29037,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":29038,"numValue":8.56,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":29039,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6518,"numValue":5.0,"position":71,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1183 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,183 | train | mutant | 6,694 | 30 | 7,336 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y71W|W85Y | Y71W|W85Y | 2 | 2 | 0 | 0 | 71 | Y | W | 5 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 71|85 | A | L|E|T | true | true | 83.461402 | 17.201477 | 14,435 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | null | Mops | 50 mM | 1RN1_A:W59Y 1RN1_B:Y45W | 52.8 | -4.4 | null | null | 95.12 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM, 2 mM","type":"BUFFER_CONC"},{"numValue":null,"strVal... | [{"datasets":[],"id":53370,"numValue":52.8,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":53371,"numValue":-4.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":53372,"numValue":95.12,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":53373,"numValue":null,"references":[... | [{"id":6518,"numValue":5.0,"position":71,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1184 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,184 | train | mutant | 6,694 | 30 | 7,336 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y71W|W85Y | Y71W|W85Y | 2 | 2 | 0 | 0 | 71 | Y | W | 5 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 71|85 | A | L|E|T | true | true | 83.461402 | 17.201477 | 14,671 | ProTherm | 7 | Absorbance | Thermal | Sodium cacodylate | 10 mM | null | 1RN1_A:W59Y 1RN1_B:Y45W | 53.1 | -4.5 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 255 | ARTICLE | Impact of point mutations on the structure and thermal stability of ribonuclease T1 in aqueous solution probed by Fourier transform infrared spectroscopy. | 1,994 | 10.1021/bi00201a021 | 8075073 | Biochemistry;33;10725-30 | 7 | Backmann J|Fabian H|Schultz C|Hahn U|Saenger W|Naumann D|Mantsch H H | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Absorbance","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium cacodylate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:W... | [{"datasets":[],"id":54253,"numValue":53.1,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":54254,"numValue":-4.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":54255,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6518,"numValue":5.0,"position":71,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:1185 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,185 | train | mutant | 6,694 | 30 | 7,336 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y71W|W85Y | Y71W|W85Y | 2 | 2 | 0 | 0 | 71 | Y | W | 5 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 71|85 | A | L|E|T | true | true | 83.461402 | 17.201477 | 15,149 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:W59Y 1RN1_B:Y45W | null | null | null | 0.91 | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":55578,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55579,"numValue":0.91,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55580,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6518,"numValue":5.0,"position":71,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1186 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,186 | train | mutant | 6,694 | 30 | 7,336 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y71W|W85Y | Y71W|W85Y | 2 | 2 | 0 | 0 | 71 | Y | W | 5 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 71|85 | A | L|E|T | true | true | 83.461402 | 17.201477 | 15,154 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:W59Y 1RN1_B:Y45W | null | null | 6.91 | null | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":55593,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55594,"numValue":6.91,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":55595,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6518,"numValue":5.0,"position":71,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1187 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,187 | train | mutant | 4,687 | 30 | 5,225 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | D75A | D75A | 1 | 1 | 0 | 0 | 75 | D | A | 3 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 75 | A | L | true | false | 136.573511 | 22.70875 | 11,047 | ProTherm | 7 | CD | Urea | MOPS | 30 mM | 25 | 1RN1_A:D49A | null | null | null | 0.5 | null | null | null | 5.67 | 1.21 | null | null | null | null | null | null | null | Unknown | DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 366 | ARTICLE | Increasing protein stability by altering long-range coulombic interactions. | 1,999 | 10.1110/ps.8.9.1843 | 10493585 | Protein Sci;8;1843-9 | 5 | Grimsley G R|Shaw K L|Fee L R|Alston R W|Huyghues-Despointes B M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"... | [{"datasets":["SAAFEC_S1262.csv"],"id":38008,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":38009,"numValue":1.21,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":38010,"numValue":5.67,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":38011,"numValue":null... | [{"id":6522,"numValue":3.0,"position":75,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1188 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,188 | train | mutant | 4,687 | 30 | 5,225 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | D75A | D75A | 1 | 1 | 0 | 0 | 75 | D | A | 3 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 75 | A | L | true | false | 136.573511 | 22.70875 | 11,048 | ProTherm | 2.5 | CD | Urea | glycine | 30 mM | 25 | 1RN1_A:D49A | null | null | null | -0.4 | null | null | null | 3.42 | 1.69 | null | null | null | null | null | null | null | Unknown | DDG|M|CM|REVERSIBILITY | guerios_625_map.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 366 | ARTICLE | Increasing protein stability by altering long-range coulombic interactions. | 1,999 | 10.1110/ps.8.9.1843 | 10493585 | Protein Sci;8;1843-9 | 5 | Grimsley G R|Shaw K L|Fee L R|Alston R W|Huyghues-Despointes B M | [{"numValue":2.5,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"glycine","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"}... | [{"datasets":["guerios_625_map.csv"],"id":38012,"numValue":-0.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":38013,"numValue":1.69,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":38014,"numValue":3.42,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":38015,"numValue":... | [{"id":6522,"numValue":3.0,"position":75,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1189 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,189 | train | mutant | 4,733 | 30 | 5,272 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | D75H | D75H | 1 | 1 | 0 | 0 | 75 | D | H | 3 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 75 | A | L | true | false | 136.573511 | 22.70875 | 11,148 | ProTherm | 7 | CD | Thermal | MOPS | 30 mM | 25 | 1RN1_A:D49H | null | null | null | -1.1 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 750 | ARTICLE | Charge-charge interactions influence the denatured state ensemble and contribute to protein stability. | 2,000 | 10.1110/ps.9.7.1395 | 10933506 | Protein Sci;9;1395-8 | 3 | Pace C N|Shaw K L|Alston R W | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"}... | [{"datasets":["khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":38350,"numValue":-1.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":38351,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":6522,"numValue":3.0,"position":75,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1190 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,190 | train | mutant | 7,281 | 30 | 7,951 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | S80G|P81N | S80G|P81N | 2 | 2 | 0 | 0 | 80 | S | G | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 80|81 | A | S|L | false | false | 63.710654 | 21.898155 | 15,606 | ProTherm | 8 | CD | Urea | Tris-HCl | 0.1 M | 15 | NaCl | 2.5 M | 1RN1_A:S54G 1RN1_A:P55N | null | null | 2.44 | null | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 937 | ARTICLE | Folding mechanism of ribonuclease T1 in the absence of the disulfide bonds. | 1,994 | 10.1021/bi00252a029 | 7981223 | Biochemistry;33;14608-19 | 2 | Schmid F X|M?cke M | [{"numValue":8.0,"strValue":null,"type":"PH"},{"numValue":15.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","type":"BUFFER_CONC"... | [{"datasets":[],"id":57262,"numValue":2.44,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":57263,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":6527,"numValue":6.0,"position":80,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6528,"numValue":5.0,"position":81,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1191 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,191 | train | mutant | 7,281 | 30 | 7,951 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | S80G|P81N | S80G|P81N | 2 | 2 | 0 | 0 | 80 | S | G | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 80|81 | A | S|L | false | false | 63.710654 | 21.898155 | 15,610 | ProTherm | 8 | Absorbance | Urea | Tris-HCl | 0.1 M | 15 | NaCl | 2.8 M | 1RN1_A:S54G 1RN1_A:P55N | null | null | 5.98 | null | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 938 | ARTICLE | Intact disulfide bonds decelerate the folding of ribonuclease T1. | 1,994 | 10.1006/jmbi.1994.1408 | 8014991 | J Mol Biol;239;713-25 | 2 | Schmid F X|M?cke M | [{"numValue":8.0,"strValue":null,"type":"PH"},{"numValue":15.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Absorbance","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","type":"BUFF... | [{"datasets":[],"id":57276,"numValue":5.98,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":57277,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":6527,"numValue":6.0,"position":80,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6528,"numValue":5.0,"position":81,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1192 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,192 | train | mutant | 7,281 | 30 | 7,951 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | S80G|P81N | S80G|P81N | 2 | 2 | 0 | 0 | 80 | S | G | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 80|81 | A | S|L | false | false | 63.710654 | 21.898155 | 15,612 | ProTherm | 5 | CD | GdnHCl | Na acetate | 0.1 M | 10 | 1RN1_A:S54G 1RN1_A:P55N | null | null | 11.21 | null | null | null | null | null | 2.8 | null | null | null | null | null | null | null | Unknown | DG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 939 | ARTICLE | Structure of a rapidly formed intermediate in ribonuclease T1 folding. | 1,992 | 10.1002/pro.5560010910 | 1304394 | Protein Sci;1;1162-72 | 3 | Kiefhaber T|Willaert K|Schmid F X | [{"numValue":5.0,"strValue":null,"type":"PH"},{"numValue":10.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Na acetate","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","type":"BUFFER_C... | [{"datasets":[],"id":57281,"numValue":11.21,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":57282,"numValue":2.8,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57283,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":6527,"numValue":6.0,"position":80,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6528,"numValue":5.0,"position":81,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:1193 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,193 | train | mutant | 644 | 30 | 697 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y82F | Y82F | 1 | 1 | 0 | 0 | 82 | Y | F | 5 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 82 | A | L|E | false | false | 23.259251 | 16.395417 | 1,061 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | null | 1RN1_A:Y56F | 48.8 | -2.1 | null | null | null | null | 99 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:Y56F","type"... | [{"datasets":[],"id":3964,"numValue":48.8,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3965,"numValue":-2.1,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3966,"numValue":99.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"i... | [{"id":6529,"numValue":5.0,"position":82,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1194 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,194 | train | mutant | 644 | 30 | 697 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y82F | Y82F | 1 | 1 | 0 | 0 | 82 | Y | F | 5 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 82 | A | L|E | false | false | 23.259251 | 16.395417 | 7,625 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | 50.9 | 1RN1_A:Y56F | null | null | null | 0.71 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":50.9,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUF... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":26315,"numValue":0.71,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26316,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6529,"numValue":5.0,"position":82,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1195 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,195 | train | mutant | 644 | 30 | 697 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y82F | Y82F | 1 | 1 | 0 | 0 | 82 | Y | F | 5 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 82 | A | L|E | false | false | 23.259251 | 16.395417 | 8,895 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30 mM | 25 | 1RN1_A:Y56F | null | null | null | 0.78 | null | null | null | 4.65 | 1.26 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|guerios_625_map.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","guerios_625_map.csv","potapov_with_uniprot_mapping.csv"],"id":30148,"numValue":0.78,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30149,"numValue":1.26,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":30150,"numValue":4... | [{"id":6529,"numValue":5.0,"position":82,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1197 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,197 | train | mutant | 645 | 30 | 698 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y83F | Y83F | 1 | 1 | 0 | 0 | 83 | Y | F | 4 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 83 | A | E | true | false | 23.585322 | 14.775417 | 7,626 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | 50.9 | 1RN1_A:Y57F | null | null | null | 0.44 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":50.9,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUF... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":26317,"numValue":0.44,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26318,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6530,"numValue":4.0,"position":83,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1198 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,198 | train | mutant | 645 | 30 | 698 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y83F | Y83F | 1 | 1 | 0 | 0 | 83 | Y | F | 4 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 83 | A | E | true | false | 23.585322 | 14.775417 | 8,896 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30 mM | 25 | 1RN1_A:Y57F | null | null | null | 0.5 | null | null | null | 4.88 | 1.29 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|guerios_625_map.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","guerios_625_map.csv","potapov_with_uniprot_mapping.csv"],"id":30152,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30153,"numValue":1.29,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":30154,"numValue":4.... | [{"id":6530,"numValue":4.0,"position":83,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1200 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,200 | train | mutant | 641 | 30 | 694 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | E84A | E84A | 1 | 1 | 0 | 0 | 84 | E | A | 9 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 84 | A | E | true | true | 12.434597 | 15.457222 | 7,760 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | 48.6 | 1RN1_A:E58A | null | null | null | 0.78 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|khan_protherm_data_mapped.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 109 | ARTICLE | Conformational stability and activity of ribonuclease T1 and mutants. Gln25----Lys, Glu58----Ala, and the double mutant. | 1,989 | 2663837 | J Biol Chem;264;11621-5 | 4 | Steyaert J|Stanssens P|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":48.6,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUF... | [{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","khan_protherm_data_mapped.csv"],"id":26645,"numValue":0.78,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26646,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":4,"numValue":null,"position":84,"positionArray":null,"positionRange":null,"strValue":"Proton acceptor","type":"ACTIVE_SITE"},{"id":6531,"numValue":9.0,"position":84,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:1201 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,201 | train | mutant | 641 | 30 | 694 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | E84A | E84A | 1 | 1 | 0 | 0 | 84 | E | A | 9 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 84 | A | E | true | true | 12.434597 | 15.457222 | 8,892 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30 mM | 25 | 1RN1_A:E58A | null | null | 4.72 | 0.9 | null | null | null | 3.92 | 1.2 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 109 | ARTICLE | Conformational stability and activity of ribonuclease T1 and mutants. Gln25----Lys, Glu58----Ala, and the double mutant. | 1,989 | 2663837 | J Biol Chem;264;11621-5 | 4 | Steyaert J|Stanssens P|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":[],"id":30135,"numValue":4.72,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":30136,"numValue":0.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30137,"numValue":1.2,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":30138,"numValue":3.92,"references":[],"s... | [{"id":4,"numValue":null,"position":84,"positionArray":null,"positionRange":null,"strValue":"Proton acceptor","type":"ACTIVE_SITE"},{"id":6531,"numValue":9.0,"position":84,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:1202 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,202 | train | mutant | 641 | 30 | 694 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | E84A | E84A | 1 | 1 | 0 | 0 | 84 | E | A | 9 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 84 | A | E | true | true | 12.434597 | 15.457222 | 10,521 | ProTherm | 6.01 | Fluorescence | Urea | MES | 30 mM | 25 | NaCl | 0.2 M | 1RN1_A:E58A | null | null | 7.6 | 0.64 | null | null | null | 5.67 | 1.34 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 686 | ARTICLE | Contribution of histidine residues to the conformational stability of ribonuclease T1 and mutant Glu-58----Ala. | 1,990 | 10.1021/bi00485a005 | 1980207 | Biochemistry;29;7572-6 | 4 | Pace C N|McNutt M|Mullins L S|Raushel F M | [{"numValue":6.01,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MES","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":[],"id":36152,"numValue":7.6,"references":[],"strValue":null,"type":"DG"},{"datasets":["potapov_with_uniprot_mapping.csv"],"id":36153,"numValue":0.64,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":36154,"numValue":1.34,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":36155... | [{"id":4,"numValue":null,"position":84,"positionArray":null,"positionRange":null,"strValue":"Proton acceptor","type":"ACTIVE_SITE"},{"id":6531,"numValue":9.0,"position":84,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1203 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,203 | train | mutant | 641 | 30 | 694 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | E84A | E84A | 1 | 1 | 0 | 0 | 84 | E | A | 9 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 84 | A | E | true | true | 12.434597 | 15.457222 | 10,522 | ProTherm | 8.01 | Fluorescence | Urea | HEPPSO | 30 mM | 25 | NaCl | 0.2 mM | 1RN1_A:E58A | null | null | 6.63 | -0.71 | null | null | null | 4.89 | 1.36 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 686 | ARTICLE | Contribution of histidine residues to the conformational stability of ribonuclease T1 and mutant Glu-58----Ala. | 1,990 | 10.1021/bi00485a005 | 1980207 | Biochemistry;29;7572-6 | 4 | Pace C N|McNutt M|Mullins L S|Raushel F M | [{"numValue":8.01,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"HEPPSO","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUF... | [{"datasets":[],"id":36157,"numValue":6.63,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv"],"id":36158,"numValue":-0.71,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":36159,"numValue":1.36,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":36160,"numValue"... | [{"id":4,"numValue":null,"position":84,"positionArray":null,"positionRange":null,"strValue":"Proton acceptor","type":"ACTIVE_SITE"},{"id":6531,"numValue":9.0,"position":84,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1204 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,204 | train | mutant | 29 | 30 | 31 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | W85Y | W85Y | 1 | 1 | 0 | 0 | 85 | W | Y | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 85 | A | E | true | false | 1.494348 | 10.665 | 29 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | null | Mops | 50 mM | 1RN1_A:W59Y | 54.3 | -2.9 | null | null | 91.78 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM, 2 mM","type":"BUFFER_CONC"},{"numValue":null,"strVal... | [{"datasets":[],"id":85,"numValue":54.3,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":86,"numValue":-2.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":87,"numValue":91.78,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":88,"... | [{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1205 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,205 | train | mutant | 29 | 30 | 31 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | W85Y | W85Y | 1 | 1 | 0 | 0 | 85 | W | Y | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 85 | A | E | true | false | 1.494348 | 10.665 | 2,916 | ProTherm | 7 | Absorbance | Thermal | Sodium cacodylate | 10 mM | null | 1RN1_A:W59Y | 53.4 | -4.2 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 255 | ARTICLE | Impact of point mutations on the structure and thermal stability of ribonuclease T1 in aqueous solution probed by Fourier transform infrared spectroscopy. | 1,994 | 10.1021/bi00201a021 | 8075073 | Biochemistry;33;10725-30 | 7 | Backmann J|Fabian H|Schultz C|Hahn U|Saenger W|Naumann D|Mantsch H H | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Absorbance","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium cacodylate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:W... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10577,"numValue":53.4,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10578,"numValue":-4.2,"references":[],"strValue":nul... | [{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1206 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,206 | train | mutant | 29 | 30 | 31 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | W85Y | W85Y | 1 | 1 | 0 | 0 | 85 | W | Y | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 85 | A | E | true | false | 1.494348 | 10.665 | 3,632 | ProTherm | 7 | Absorbance | Thermal | Sodium cacodylate-D2O | 100 mM | null | 1RN1_A:W59Y | 65 | 20 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 341 | ARTICLE | New structural insights into the refolding of ribonuclease T1 as seen by time-resolved Fourier-transform infrared spectroscopy. | 1,999 | 10.1002/(sici)1097-0134(19990215)34:3<303::aid-prot4>3.0.co;2-h | 10024018 | Proteins;34;303-16 | 3 | Fabian H|Naumann D|Reinst?dler D | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Absorbance","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium cacodylate-D2O","type":"BUFFER"},{"numValue":null,"strValue":"100 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":13344,"numValue":65.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":13345,"numValue":20.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":["AUTOMUTE_S19... | [{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1207 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,207 | train | mutant | 29 | 30 | 31 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | W85Y | W85Y | 1 | 1 | 0 | 0 | 85 | W | Y | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 85 | A | E | true | false | 1.494348 | 10.665 | 8,548 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:W59Y | null | null | null | 0.93 | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":29010,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":29011,"numValue":0.93,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":29012,... | [{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:1208 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,208 | train | mutant | 29 | 30 | 31 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | W85Y | W85Y | 1 | 1 | 0 | 0 | 85 | W | Y | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 85 | A | E | true | false | 1.494348 | 10.665 | 8,554 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:W59Y | null | null | 6.88 | null | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":29028,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":29029,"numValue":6.88,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":29030,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:1209 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,209 | train | mutant | 6,696 | 30 | 7,338 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | W85Y|H118A | W85Y|H118A | 2 | 2 | 0 | 0 | 85 | W | Y | 8 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 85|118 | A | E|L|S | true | true | 23.837804 | 11.534 | 14,437 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | null | Mops | 50 mM | 1RN1_A:W59Y 1RN1_A:H92A | 53.2 | -4 | null | null | 87 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM, 2 mM","type":"BUFFER_CONC"},{"numValue":null,"strVal... | [{"datasets":[],"id":53378,"numValue":53.2,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":53379,"numValue":-4.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":53380,"numValue":87.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":53381,"numValue":null,"references":[]... | [{"id":5,"numValue":null,"position":118,"positionArray":null,"positionRange":null,"strValue":"Proton donor","type":"ACTIVE_SITE"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6565,"numValue":9.0,"position":118,"positionArray":null,"positi... | |||||||||||
fireprotdb:1210 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,210 | train | mutant | 6,696 | 30 | 7,338 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | W85Y|H118A | W85Y|H118A | 2 | 2 | 0 | 0 | 85 | W | Y | 8 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 85|118 | A | E|L|S | true | true | 23.837804 | 11.534 | 15,151 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:W59Y 1RN1_A:H92A | null | null | null | 1.53 | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":55584,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55585,"numValue":1.53,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55586,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":5,"numValue":null,"position":118,"positionArray":null,"positionRange":null,"strValue":"Proton donor","type":"ACTIVE_SITE"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6565,"numValue":9.0,"position":118,"positionArray":null,"positi... | |||||||||||
fireprotdb:1211 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,211 | train | mutant | 6,696 | 30 | 7,338 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | W85Y|H118A | W85Y|H118A | 2 | 2 | 0 | 0 | 85 | W | Y | 8 | ACTIVE_SITE|CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 85|118 | A | E|L|S | true | true | 23.837804 | 11.534 | 15,156 | ProTherm | 6 | DSC | Thermal | sodium acetate, calcium acetate | 20 mM, 2 mM | 25 | Mops | 50 mM | 1RN1_A:W59Y 1RN1_A:H92A | null | null | 6.26 | null | null | 0.98 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 3 | ARTICLE | X-ray crystallographic and calorimetric studies of the effects of the mutation Trp59-->Tyr in ribonuclease T1. | 1,994 | 10.1111/j.1432-1033.1994.tb18652.x | 8125111 | Eur J Biochem;220;527-34 | 4 | Schluckebier G|Backmann J|Granzin J|Schubert W D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium acetate, calcium acetate","type":"BUFFER"},{"numValue":null,"strValue":"... | [{"datasets":[],"id":55599,"numValue":0.98,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55600,"numValue":6.26,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":55601,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":5,"numValue":null,"position":118,"positionArray":null,"positionRange":null,"strValue":"Proton donor","type":"ACTIVE_SITE"},{"id":6532,"numValue":8.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6565,"numValue":9.0,"position":118,"positionArray":null,"positi... | |||||||||||
fireprotdb:1212 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,212 | train | mutant | 5,801 | 30 | 6,357 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | I87V | I87V | 1 | 1 | 0 | 0 | 87 | I | V | 8 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 87 | A | L|B | true | false | 7.978055 | 10.35 | 12,519 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30mM | 25 | 9RNT_A:I61V | null | null | 4.6 | 1.8 | null | null | null | 3.64 | 1.23 | null | null | null | null | null | null | null | yes | 2.0 | DG|DDG|M|CM|STATE|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 519 | ARTICLE | Contribution of hydrophobic interactions to protein stability. | 2,011 | 10.1016/j.jmb.2011.02.053 | 21377472 | J Mol Biol;408;514-28 | 11 | Scholtz J Martin|Pace C Nick|Trevino Saul R|Fu Hailong|Landua John|Gajiwala Ketan|Shirley Bret A|Grimsley Gerald R|Fryar Katrina Lee|Hendricks Marsha McNutt|Iimura Satoshi | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30mM","type":"BUFFER_... | [{"datasets":[],"id":45391,"numValue":4.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":45392,"numValue":1.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":45393,"numValue":1.23,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":45394,"numValue":3.64,"references":[],"s... | [{"id":6534,"numValue":8.0,"position":87,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1214 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,214 | train | mutant | 649 | 30 | 702 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | S90A | S90A | 1 | 1 | 0 | 0 | 90 | S | A | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 90 | A | T | false | false | 85.737686 | 18.9225 | 7,630 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | 50.9 | 1RN1_A:S64A | null | null | null | 1.56 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | capriotti_S1615_map.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":50.9,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUF... | [{"datasets":["capriotti_S1615_map.csv"],"id":26325,"numValue":1.56,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26326,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6537,"numValue":6.0,"position":90,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1215 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,215 | train | mutant | 649 | 30 | 702 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | S90A | S90A | 1 | 1 | 0 | 0 | 90 | S | A | 6 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 90 | A | T | false | false | 85.737686 | 18.9225 | 8,900 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30 mM | 25 | 1RN1_A:S64A | null | null | null | 1.44 | null | null | null | 4.11 | 1.38 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":30168,"numValue":1.44,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30169,"numValue":1.38,"references":[],"strValue":null,"type":"M"},{"data... | [{"id":6537,"numValue":6.0,"position":90,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1216 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,216 | train | mutant | 646 | 30 | 699 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y94F | Y94F | 1 | 1 | 0 | 0 | 94 | Y | F | 9 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 94 | A | L | true | false | 10.453242 | 13.1 | 1,063 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | null | 1RN1_A:Y68F | 46.9 | -4 | null | null | null | null | 89 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1749.csv|HotMuSiC_S1626.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:Y68F","type"... | [{"datasets":[],"id":3972,"numValue":46.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","HotMuSiC_S1626.csv","Saraboji_S1791.csv"],"id":3973,"numValue":-4.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3974,"numValue":89.0,"references":[],"strValue":null,"type":"DHV... | [{"id":6541,"numValue":9.0,"position":94,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1217 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,217 | train | mutant | 646 | 30 | 699 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y94F | Y94F | 1 | 1 | 0 | 0 | 94 | Y | F | 9 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 94 | A | L | true | false | 10.453242 | 13.1 | 7,627 | ProTherm | 7 | Fluorescence | Thermal | MOPS | 30 mM | 50.9 | 1RN1_A:Y68F | null | null | null | 1.35 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":50.9,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUF... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":26319,"numValue":1.35,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26320,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":6541,"numValue":9.0,"position":94,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1218 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,218 | train | mutant | 646 | 30 | 699 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | Y94F | Y94F | 1 | 1 | 0 | 0 | 94 | Y | F | 9 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 94 | A | L | true | false | 10.453242 | 13.1 | 8,897 | ProTherm | 7 | Fluorescence | Urea | MOPS | 30 mM | 25 | 1RN1_A:Y68F | null | null | null | 1.36 | null | null | null | 4.17 | 1.32 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | capriotti_S1615_map.csv|capriotti_S388_map.csv|guerios_625_map.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 110 | ARTICLE | Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. | 1,992 | 10.1021/bi00118a013 | 1731929 | Biochemistry;31;725-32 | 4 | Stanssens P|Hahn U|Shirley B A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER... | [{"datasets":["capriotti_S1615_map.csv","capriotti_S388_map.csv","guerios_625_map.csv","potapov_with_uniprot_mapping.csv"],"id":30156,"numValue":1.36,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30157,"numValue":1.32,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":30158,"numValue":4... | [{"id":6541,"numValue":9.0,"position":94,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1220 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,220 | train | mutant | 4,803 | 30 | 5,344 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | P99V | P99V | 1 | 1 | 0 | 0 | 99 | P | V | 9 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 99 | A | L | false | false | 29.73664 | 13.674286 | 11,283 | ProTherm | 8 | Fluorescence | GdnHCl | PIPES | 0.1 M | 25 | 1RN1_A:P73V | null | null | null | -2.01 | null | null | null | 1.66 | 2.7 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 753 | ARTICLE | The role of a trans-proline in the folding mechanism of ribonuclease T1. | 1,996 | 10.1111/j.1432-1033.1996.00516.x | 8917450 | Eur J Biochem;241;516-24 | 5 | Hahn U|Schindler T|Landt O|Schmid F X|Mayr L M | [{"numValue":8.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"PIPES","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","type":"BUF... | [{"datasets":["SAAFEC_S1262.csv"],"id":38866,"numValue":-2.01,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":38867,"numValue":2.7,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":38868,"numValue":1.66,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":38869,"numValue":nul... | [{"id":6546,"numValue":9.0,"position":99,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1221 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,221 | train | mutant | 4,803 | 30 | 5,344 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | P99V | P99V | 1 | 1 | 0 | 0 | 99 | P | V | 9 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 99 | A | L | false | false | 29.73664 | 13.674286 | 14,097 | ProTherm | 5 | Fluorescence | GdnHCl | Sodium acetate | 0.1 M | 10 | 1RN1_A:P73V | null | null | null | -1.53 | null | null | null | 3.43 | 3.01 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 753 | ARTICLE | The role of a trans-proline in the folding mechanism of ribonuclease T1. | 1,996 | 10.1111/j.1432-1033.1996.00516.x | 8917450 | Eur J Biochem;241;516-24 | 5 | Hahn U|Schindler T|Landt O|Schmid F X|Mayr L M | [{"numValue":5.0,"strValue":null,"type":"PH"},{"numValue":10.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","t... | [{"datasets":[],"id":52146,"numValue":-1.53,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":52147,"numValue":3.01,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":52148,"numValue":3.43,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":52149,"numValue":null,"references":[]... | [{"id":6546,"numValue":9.0,"position":99,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:1222 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,222 | train | mutant | 4,803 | 30 | 5,344 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | P99V | P99V | 1 | 1 | 0 | 0 | 99 | P | V | 9 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 99 | A | L | false | false | 29.73664 | 13.674286 | 14,098 | ProTherm | 8 | Fluorescence | GdnHCl | PIPES | 0.1 M | 10 | 1RN1_A:P73V | null | null | null | -2.44 | null | null | null | 2.44 | 3.18 | null | null | null | null | null | null | null | yes | DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 753 | ARTICLE | The role of a trans-proline in the folding mechanism of ribonuclease T1. | 1,996 | 10.1111/j.1432-1033.1996.00516.x | 8917450 | Eur J Biochem;241;516-24 | 5 | Hahn U|Schindler T|Landt O|Schmid F X|Mayr L M | [{"numValue":8.0,"strValue":null,"type":"PH"},{"numValue":10.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"PIPES","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","type":"BUF... | [{"datasets":[],"id":52150,"numValue":-2.44,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":52151,"numValue":3.18,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":52152,"numValue":2.44,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":52153,"numValue":null,"references":[]... | [{"id":6546,"numValue":9.0,"position":99,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:1223 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,223 | train | mutant | 1,885 | 30 | 2,114 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | D102N | D102N | 1 | 1 | 0 | 0 | 102 | D | N | 9 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 102 | A | L|E | false | false | 10.063041 | 9.579375 | 3,633 | ProTherm | 7 | DSC | Thermal | MOPS | 30 mM | null | 1RN1_A:D76N | 37 | -13.8 | null | null | 76 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|Broom_S605.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 342 | ARTICLE | Buried, charged, non-ion-paired aspartic acid 76 contributes favorably to the conformational stability of ribonuclease T1. | 1,999 | 10.1021/bi991422s | 10529213 | Biochemistry;38;13379-84 | 2 | Giletto A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1RN1_A:D76N","type":"_PDB_CH... | [{"datasets":["AUTOMUTE_S1962.csv","Broom_S605.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":13347,"numValue":37.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":13348,"numValue":-13.8,"references"... | [{"id":6549,"numValue":9.0,"position":102,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:1224 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 1,224 | train | mutant | 1,885 | 30 | 2,114 | 130 | 130 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | 2 | Guanyl-specific ribonuclease T1 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 1 | P00651 | IPR000026|IPR016191|IPR051386|IPR048269 | 4.6.1.24 | D102N | D102N | 1 | 1 | 0 | 0 | 102 | D | N | 9 | CONSERVATION | 1YGW|1RN1|9RNT | 135|350|420 | null | 102 | A | L|E | false | false | 10.063041 | 9.579375 | 10,906 | ProTherm | 7 | DSC | Urea | MOPS | 30 mM | 25 | 1RN1_A:D76N | null | null | 2.58 | 3.51 | null | null | null | 1.8 | 1.44 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 342 | ARTICLE | Buried, charged, non-ion-paired aspartic acid 76 contributes favorably to the conformational stability of ribonuclease T1. | 1,999 | 10.1021/bi991422s | 10529213 | Biochemistry;38;13379-84 | 2 | Giletto A|Pace C N | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"MOPS","type":"BUFFER"},{"numValue":null,"strValue":"30 mM","type":"BUFFER_CONC"},{... | [{"datasets":[],"id":37560,"numValue":2.58,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":37561,"numValue":3.51,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":37562,"numValue":1.44,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":37563,"numValue":1.8,"references":[],"... | [{"id":6549,"numValue":9.0,"position":102,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] |
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