row_id
string
dataset_id
string
source_dataset
string
source_file
string
source_table
string
source_sha
string
row_index
int64
split
string
subject_type
string
entry_id
int64
sequence_id
int64
target_sequence_id
int64
source_sequence_length
int64
target_sequence_length
int64
protein_id
int64
protein_name
string
organism
string
isoform
int64
protein_ids
string
protein_names
string
organisms
string
isoforms
string
uniprot_accessions
string
interpro_accessions
string
ec_numbers
string
megascale_ids
string
other_references
string
mutations
string
substitutions
string
deletions
string
insertions
string
mutation_count
int64
substitution_count
int64
deletion_count
int64
insertion_count
int64
first_position
int64
first_source_aa
string
first_target_aa
string
conservation
float64
feature_types
string
pdb_ids
string
afdb_ids
string
structure_ids
string
structure_methods
string
structure_resolution_min
float64
residue_positions
string
residue_chain_names
string
residue_secondary_structures
string
residue_in_pocket_any
bool
residue_in_tunnel_any
bool
residue_asa_mean
float64
residue_bfactor_mean
float64
experiment_id
int64
experiment_dataset
string
ph
float64
measure
string
method
string
buffer
string
buffer_conc
string
exp_temperature
float64
ion
string
ion_conc
string
pdb_chain_mutation
string
tm
float64
dtm
float64
dg
float64
dg_text
string
ddg
float64
dh
float64
dcp
float64
dhvh
float64
cm
float64
m_value
float64
trypsin_ml
float64
chymotrypsin_ml
float64
stabilizing
float64
stabilizing_text
string
domainome_fitness
float64
domainome_fitness_std
float64
domainome_ddg
float64
domainome_ddg_std
float64
reversibility
string
state
string
measurement_types
string
measurement_datasets
string
annotation_types
string
publication_id
string
publication_type
string
publication_title
string
publication_year
int64
publication_doi
string
publication_pmid
string
publication_journal
string
publication_url
string
publication_author_count
int64
publication_authors
string
annotations_json
string
measurements_json
string
features_json
string
fireprotdb:2767
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,767
train
mutant
171
41
199
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A129M
A129M
1
1
0
0
129
A
M
9
CONSERVATION
1L63|2LZM
49|80
null
129
A
H
true
false
0.335927
17.62
6,780
ProTherm
5.4
CD
Thermal
Acetic acid,Sodium acetate
1.4 mM,8.6 mM
65.3
NaCl
0.10 M
2LZM_A:A129M
null
null
null
1.9
null
2.5
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
34
ARTICLE
Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme.
1,996
10.1006/jmbi.1996.0338
8676387
J Mol Biol;259;542-59
5
Baldwin E|Xu J|Hajiseyedjavadi O|Baase W A|Matthews B W
[{"numValue":5.4,"strValue":null,"type":"PH"},{"numValue":65.3,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid,Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"1.4 mM...
[{"datasets":[],"id":24042,"numValue":2.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":24043,"numValue":1.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":24044,"numValue":null,"references...
[{"id":6920,"numValue":9.0,"position":129,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2768
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,768
train
mutant
171
41
199
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A129M
A129M
1
1
0
0
129
A
M
9
CONSERVATION
1L63|2LZM
49|80
null
129
A
H
true
false
0.335927
17.62
6,813
ProTherm
5.4
CD, Fluorescence
Thermal
acetic acid, sodium acetate
1.4 mM, 8.6 mM
65.3
Sodium Chloride
0.10 M
1L63_A:A129M
null
null
null
1.9
null
null
null
null
null
null
null
null
null
null
null
null
Yes(80%)
2.0
DDG|STATE|REVERSIBILITY
khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
215
ARTICLE
Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
1,999
10.1021/bi9915519
10545167
Biochemistry;38;14451-60
6
Lu J|Baase W A|Matthews B W|Gassner N C|Lindstrom J D|Dahlquist F W
[{"numValue":5.4,"strValue":null,"type":"PH"},{"numValue":65.3,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD, Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"acetic acid, sodium acetate","type":"BUFFER"},{"numValue":null,"st...
[{"datasets":["khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":24141,"numValue":1.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":24142,"numValue":2.0,"references":[],"strValue":null,"type":"STATE"},{"datasets":[],"id":24143,"numValue":null,"references":[],"strValue":"Yes(80%...
[{"id":6920,"numValue":9.0,"position":129,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2769
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,769
train
mutant
435
41
481
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A129V
A129V
1
1
0
0
129
A
V
9
CONSERVATION
1L63|2LZM
49|80
null
129
A
H
true
false
0.335927
17.62
708
ProTherm
1.99
CD
Thermal
Unknown
null
KCl
0.2 M
2LZM_A:A129V
38.5
-2.9
null
null
null
null
78
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1925.csv|EASE-MM_S1676.csv|HotMuSiC_S1626.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S2760.csv|PoPMuSiC-2.0_S2648.csv|Saraboji_S1396.csv|STRUM_Q3421.csv|SVM-WIN31_SVM-3D12_S1634.csv|SVM-WIN31_SVM-3D12_S1681.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
79
ARTICLE
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants.
1,989
10.1073/pnas.86.21.8237
2682639
Proc Natl Acad Sci U S A;86;8237-41
4
Baase W A|Matthews B W|Matsumura M|Karpusas M
[{"numValue":1.99,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue":null,"strValue":"0.2 M","type":"ION_CONC"},{"numValu...
[{"datasets":["AUTOMUTE_S1925.csv","EASE-MM_S1676.csv","HotMuSiC_S1626.csv","I_Mutant2.0_S1948.csv","I_Mutant2.0_S2087.csv","iPTREE-STAB_S1859.csv","M47andM8_S2760.csv","PoPMuSiC-2.0_S2648.csv","Saraboji_S1396.csv","STRUM_Q3421.csv","SVM-WIN31_SVM-3D12_S1634.csv","SVM-WIN31_SVM-3D12_S1681.csv"],"id":2748,"numValue":38....
[{"id":6920,"numValue":9.0,"position":129,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2770
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,770
train
mutant
435
41
481
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A129V
A129V
1
1
0
0
129
A
V
9
CONSERVATION
1L63|2LZM
49|80
null
129
A
H
true
false
0.335927
17.62
710
ProTherm
2.8
CD
Thermal
Unknown
null
KCl
0.2 M
2LZM_A:A129V
50.2
-1.9
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
79
ARTICLE
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants.
1,989
10.1073/pnas.86.21.8237
2682639
Proc Natl Acad Sci U S A;86;8237-41
4
Baase W A|Matthews B W|Matsumura M|Karpusas M
[{"numValue":2.8,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue":null,"strValue":"0.2 M","type":"ION_CONC"},{"numValue...
[{"datasets":[],"id":2755,"numValue":50.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":2756,"numValue":-1.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":2757,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6920,"numValue":9.0,"position":129,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2771
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,771
train
mutant
435
41
481
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A129V
A129V
1
1
0
0
129
A
V
9
CONSERVATION
1L63|2LZM
49|80
null
129
A
H
true
false
0.335927
17.62
7,463
ProTherm
2.8
CD
Thermal
Unknown
52.1
KCl
0.2 M
2LZM_A:A129V
null
null
null
0.7
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
79
ARTICLE
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants.
1,989
10.1073/pnas.86.21.8237
2682639
Proc Natl Acad Sci U S A;86;8237-41
4
Baase W A|Matthews B W|Matsumura M|Karpusas M
[{"numValue":2.8,"strValue":null,"type":"PH"},{"numValue":52.1,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numV...
[{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":25922,"numValue":0.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":25923,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6920,"numValue":9.0,"position":129,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2772
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,772
train
mutant
435
41
481
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A129V
A129V
1
1
0
0
129
A
V
9
CONSERVATION
1L63|2LZM
49|80
null
129
A
H
true
false
0.335927
17.62
8,056
ProTherm
1.99
CD
Thermal
Unknown
41.4
KCl
0.2 M
2LZM_A:A129V
null
null
null
0.8
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
79
ARTICLE
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants.
1,989
10.1073/pnas.86.21.8237
2682639
Proc Natl Acad Sci U S A;86;8237-41
4
Baase W A|Matthews B W|Matsumura M|Karpusas M
[{"numValue":1.99,"strValue":null,"type":"PH"},{"numValue":41.4,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"num...
[{"datasets":["capriotti_S1615_map.csv","potapov_with_uniprot_mapping.csv"],"id":27427,"numValue":0.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27428,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6920,"numValue":9.0,"position":129,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2773
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,773
train
mutant
1,966
41
2,196
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A129F
A129F
1
1
0
0
129
A
F
9
CONSERVATION
1L63|2LZM
49|80
null
129
A
H
true
false
0.335927
17.62
3,786
ProTherm
3
CD
Thermal
phosphoric acid,Potassium phosphate,
3 mM,17 mM,
null
KCl
25 mM
2LZM_A:A129F
49.4
-2.3
null
null
null
null
94
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
350
ARTICLE
The introduction of strain and its effects on the structure and stability of T4 lysozyme.
2,000
10.1006/jmbi.1999.3300
10623513
J Mol Biol;295;127-45
3
Liu R|Baase W A|Matthews B W
[{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphoric acid,Potassium phosphate,","type":"BUFFER"},{"numValue":null,"strValue":"3 mM,17 mM,","type":"BUFFER_CONC"},{"numValue":null,"st...
[{"datasets":["STRUM_Q3421.csv"],"id":13978,"numValue":49.4,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv","STRUM_Q3421.csv"],"id":13979,"numValue":-2.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":["STRUM_Q3421.csv"],"id":13980,"numValue":94.0,"referenc...
[{"id":6920,"numValue":9.0,"position":129,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2774
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,774
train
mutant
1,967
41
2,197
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A129W
A129W
1
1
0
0
129
A
W
9
CONSERVATION
1L63|2LZM
49|80
null
129
A
H
true
false
0.335927
17.62
3,787
ProTherm
3
CD
Thermal
phosphoric acid,Potassium phosphate,
3 mM,17 mM,
null
KCl
25 mM
2LZM_A:A129W
46.6
-5.1
null
null
null
null
80
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
EASE-MM_S543.csv|PoPMuSiC-2.0_S2648.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
350
ARTICLE
The introduction of strain and its effects on the structure and stability of T4 lysozyme.
2,000
10.1006/jmbi.1999.3300
10623513
J Mol Biol;295;127-45
3
Liu R|Baase W A|Matthews B W
[{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphoric acid,Potassium phosphate,","type":"BUFFER"},{"numValue":null,"strValue":"3 mM,17 mM,","type":"BUFFER_CONC"},{"numValue":null,"st...
[{"datasets":["EASE-MM_S543.csv","PoPMuSiC-2.0_S2648.csv","STRUM_Q3421.csv"],"id":13982,"numValue":46.6,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv","STRUM_Q3421.csv"],"id":13983,"numValue":-5.1,"references":[],"strValue":null,"type":"DTM"},{"datasets":["STRUM_Q342...
[{"id":6920,"numValue":9.0,"position":129,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2775
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,775
train
mutant
6,720
41
7,362
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A129M|F153A
A129M|F153A
2
2
0
0
129
A
M
9
CONSERVATION
1L63|2LZM
49|80
null
129|153
A
H
true
false
0.53304
17.304545
14,479
ProTherm
5.4
CD
Thermal
Acetic acid,Sodium acetate,
1.4 mM,8.6 mM,
null
NaCl
0.10 M
2LZM_A:A129M 2LZM_A:F153A
52.6
-12.7
null
null
null
2.5
94
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DCP|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
34
ARTICLE
Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme.
1,996
10.1006/jmbi.1996.0338
8676387
J Mol Biol;259;542-59
5
Baldwin E|Xu J|Hajiseyedjavadi O|Baase W A|Matthews B W
[{"numValue":5.4,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid,Sodium acetate,","type":"BUFFER"},{"numValue":null,"strValue":"1.4 mM,8.6 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue...
[{"datasets":[],"id":53535,"numValue":52.6,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":53536,"numValue":-12.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":53537,"numValue":2.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":53538,"numValue":94.0,"references":[...
[{"id":6920,"numValue":9.0,"position":129,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6944,"numValue":7.0,"position":153,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2776
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,776
train
mutant
6,720
41
7,362
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A129M|F153A
A129M|F153A
2
2
0
0
129
A
M
9
CONSERVATION
1L63|2LZM
49|80
null
129|153
A
H
true
false
0.53304
17.304545
14,910
ProTherm
5.4
CD
Thermal
Acetic acid,Sodium acetate
1.4 mM,8.6 mM
65.3
NaCl
0.10 M
2LZM_A:A129M 2LZM_A:F153A
null
null
null
4.3
null
2.5
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
34
ARTICLE
Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme.
1,996
10.1006/jmbi.1996.0338
8676387
J Mol Biol;259;542-59
5
Baldwin E|Xu J|Hajiseyedjavadi O|Baase W A|Matthews B W
[{"numValue":5.4,"strValue":null,"type":"PH"},{"numValue":65.3,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid,Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"1.4 mM...
[{"datasets":[],"id":54966,"numValue":2.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":54967,"numValue":4.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":54968,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6920,"numValue":9.0,"position":129,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6944,"numValue":7.0,"position":153,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2777
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,777
train
mutant
236
41
266
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A130S
A130S
1
1
0
0
130
A
S
7
CONSERVATION
1L63|2LZM
49|80
null
130
A
H
true
false
9.026523
18.654
422
ProTherm
3
CD
Thermal
Potassium phosphate
20 mM
null
KCl
25 mM
2LZM_A:A130S
48.66
-2.89
null
null
null
null
107
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
44
ARTICLE
Energetic cost and structural consequences of burying a hydroxyl group within the core of a protein determined from Ala-->Ser and Val-->Thr substitutions in T4 lysozyme.
1,993
10.1021/bi00093a013
8218201
Biochemistry;32;11363-73
6
Xu J|Blaber M|Gassner N|Heinz D W|Matthews B W|Lindstrom J D
[{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"I...
[{"datasets":[],"id":1739,"numValue":48.66,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":1740,"numValue":-2.89,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":1741,"numValue":107.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[]...
[{"id":6921,"numValue":7.0,"position":130,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2778
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,778
train
mutant
236
41
266
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A130S
A130S
1
1
0
0
130
A
S
7
CONSERVATION
1L63|2LZM
49|80
null
130
A
H
true
false
9.026523
18.654
7,591
ProTherm
3
CD
Thermal
Potassium phosphate
20 mM
51.55
KCl
25 mM
2LZM_A:A130S
null
null
null
1
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
44
ARTICLE
Energetic cost and structural consequences of burying a hydroxyl group within the core of a protein determined from Ala-->Ser and Val-->Thr substitutions in T4 lysozyme.
1,993
10.1021/bi00093a013
8218201
Biochemistry;32;11363-73
6
Xu J|Blaber M|Gassner N|Heinz D W|Matthews B W|Lindstrom J D
[{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":51.55,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type...
[{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":26239,"numValue":1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26240,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6921,"numValue":7.0,"position":130,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2779
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,779
train
mutant
4,336
41
4,845
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A130G
A130G
1
1
0
0
130
A
G
7
CONSERVATION
1L63|2LZM
49|80
null
130
A
H
true
false
9.026523
18.654
10,026
ProTherm
6
CD
Urea
Potassium phosphate
20 mM
25
NaCl
100 mM
2LZM_A:A130G
null
null
12.8
2.1
null
null
null
null
2.6
null
null
null
null
null
null
null
Unknown
DG|DDG|M|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
664
ARTICLE
Exploring subdomain cooperativity in T4 lysozyme II: uncovering the C-terminal subdomain as a hidden intermediate in the kinetic folding pathway.
2,007
10.1110/ps.062632807
17400925
Protein Sci;16;852-62
3
Marqusee Susan|Cellitti Jason|Bernstein Rachel
[{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"B...
[{"datasets":[],"id":34441,"numValue":12.8,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":34442,"numValue":2.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":34443,"numValue":2.6,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":34444,"numValue":null,...
[{"id":6921,"numValue":7.0,"position":130,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2780
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,780
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
583
ProTherm
2.02
CD
Thermal
Unknown
null
KCl
0.2 M
2LZM_A:V131A
41.25
1
null
null
null
2.4
88.7
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DCP|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv|M47andM8_S2760.csv
PH|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
63
ARTICLE
Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability.
1,992
10.1002/pro.5560010608
1304917
Protein Sci;1;761-76
3
Baase W A|Zhang X J|Matthews B W
[{"numValue":2.02,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue":null,"strValue":"0.2 M","type":"ION_CONC"},{"numValu...
[{"datasets":[],"id":2320,"numValue":41.25,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":2321,"numValue":1.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":2322,"numValue":2.4,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id"...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2781
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,781
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
903
ProTherm
3
CD
Thermal
KH2PO4,H3PO4,
17 mM,3 mM,
null
KCl
25 mM
2LZM_A:V131A
54.14
0.72
null
null
null
1.8
123
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DCP|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
97
ARTICLE
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive.
1,995
10.1093/protein/8.10.1017
8771182
Protein Eng;8;1017-22
5
Baase W A|Zhang X J|Matthews B W|Shoichet B K|Wilson K P
[{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4,H3PO4,","type":"BUFFER"},{"numValue":null,"strValue":"17 mM,3 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"I...
[{"datasets":[],"id":3346,"numValue":54.14,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3347,"numValue":0.72,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3348,"numValue":1.8,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2782
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,782
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
910
ProTherm
5.4
CD
Thermal
Acetic acid,Sodium acetate,
1.4 mM,8.6 mM,
null
NaCl
100 mM
2LZM_A:V131A
67.38
0.87
null
null
null
2.5
140
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DCP|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
97
ARTICLE
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive.
1,995
10.1093/protein/8.10.1017
8771182
Protein Eng;8;1017-22
5
Baase W A|Zhang X J|Matthews B W|Shoichet B K|Wilson K P
[{"numValue":5.4,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid,Sodium acetate,","type":"BUFFER"},{"numValue":null,"strValue":"1.4 mM,8.6 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue...
[{"datasets":[],"id":3381,"numValue":67.38,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3382,"numValue":0.87,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3383,"numValue":2.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2783
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,783
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
949
ProTherm
3.01
CD
Thermal
KH2PO4,H3PO4,
17 mM,3 mM,
null
KCl
25 mM
2LZM_A:V131A
53.74
0.66
null
null
null
null
128
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4,H3PO4,","type":"BUFFER"},{"numValue":null,"strValue":"17 mM,3 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"...
[{"datasets":[],"id":3557,"numValue":53.74,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3558,"numValue":0.66,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3559,"numValue":128.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2784
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,784
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
993
ProTherm
2.03
CD
Thermal
Unknown
null
KCl
0.2 M
2LZM_A:V131A
42.03
0.56
null
null
null
null
84.8
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
103
ARTICLE
A mutant T4 lysozyme (Val 131----Ala) designed to increase thermostability by the reduction of strain within an alpha-helix.
1,990
10.1002/prot.340070208
2326253
Proteins;7;198-204
3
Baase W A|Matthews B W|Dao-Pin S
[{"numValue":2.03,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue":null,"strValue":"0.2 M","type":"ION_CONC"},{"numValu...
[{"datasets":[],"id":3721,"numValue":42.03,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3722,"numValue":0.56,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3723,"numValue":84.8,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2785
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,785
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
996
ProTherm
2.83
CD
Thermal
Unknown
null
KCl
0.2 M
2LZM_A:V131A
52
0.9
null
null
null
null
106.3
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
103
ARTICLE
A mutant T4 lysozyme (Val 131----Ala) designed to increase thermostability by the reduction of strain within an alpha-helix.
1,990
10.1002/prot.340070208
2326253
Proteins;7;198-204
3
Baase W A|Matthews B W|Dao-Pin S
[{"numValue":2.83,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue":null,"strValue":"0.2 M","type":"ION_CONC"},{"numValu...
[{"datasets":[],"id":3733,"numValue":52.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3734,"numValue":0.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3735,"numValue":106.3,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"i...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2787
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,787
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
6,725
ProTherm
5.4
CD
Thermal
Acetic acid, Sodium acetate
1.4 mM, 8.6 mM
66.51
NaCl
100 mM
2LZM_A:V131A
null
null
null
-0.39
null
2.5
null
null
null
null
null
null
null
null
null
null
Unknown
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|guerios_625_map.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
97
ARTICLE
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive.
1,995
10.1093/protein/8.10.1017
8771182
Protein Eng;8;1017-22
5
Baase W A|Zhang X J|Matthews B W|Shoichet B K|Wilson K P
[{"numValue":5.4,"strValue":null,"type":"PH"},{"numValue":66.51,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid, Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"1.4 ...
[{"datasets":[],"id":23897,"numValue":2.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","potapov_with_uniprot_mapping.csv"],"id":23898,"numValue":-0.39,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":23899,"numValue":null,"references":[],"st...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2788
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,788
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
7,340
ProTherm
3
CD
Thermal
KH2PO4, H3PO4
17 mM, 3 mM
53.42
KCl
25 mM
2LZM_A:V131A
null
null
null
-0.33
null
1.8
null
null
null
null
null
null
null
null
null
null
Unknown
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
97
ARTICLE
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive.
1,995
10.1093/protein/8.10.1017
8771182
Protein Eng;8;1017-22
5
Baase W A|Zhang X J|Matthews B W|Shoichet B K|Wilson K P
[{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":53.42,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4, H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"17 mM, 3 mM","type...
[{"datasets":[],"id":25601,"numValue":1.8,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv"],"id":25602,"numValue":-0.33,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":25603,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2789
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,789
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
7,387
ProTherm
3.01
CD
Thermal
KH2PO4, H3PO4
17 mM, 3 mM
53.08
KCl
25 mM
2LZM_A:V131A
null
null
null
-0.26
null
2.4
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":53.08,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4, H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"17 mM, 3 mM","typ...
[{"datasets":[],"id":25727,"numValue":2.4,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv"],"id":25728,"numValue":-0.26,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":25729,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2790
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,790
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
7,611
ProTherm
2.83
CD
Thermal
K2HPO4, NaH2PO4
1.05 M, 1.26 M
51.1
KCl
0.2 M
2LZM_A:V131A
null
null
null
-0.3
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
103
ARTICLE
A mutant T4 lysozyme (Val 131----Ala) designed to increase thermostability by the reduction of strain within an alpha-helix.
1,990
10.1002/prot.340070208
2326253
Proteins;7;198-204
3
Baase W A|Matthews B W|Dao-Pin S
[{"numValue":2.83,"strValue":null,"type":"PH"},{"numValue":51.1,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"K2HPO4, NaH2PO4","type":"BUFFER"},{"numValue":null,"strValue":"1.05 M, 1.26 M",...
[{"datasets":["capriotti_S1615_map.csv"],"id":26287,"numValue":-0.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26288,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2791
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,791
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
8,052
ProTherm
2.03
CD
Thermal
K2HPO4, NaH2PO4
1.05 M, 1.26 M
41.47
KCl
0.2 M
2LZM_A:V131A
null
null
null
-0.15
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
103
ARTICLE
A mutant T4 lysozyme (Val 131----Ala) designed to increase thermostability by the reduction of strain within an alpha-helix.
1,990
10.1002/prot.340070208
2326253
Proteins;7;198-204
3
Baase W A|Matthews B W|Dao-Pin S
[{"numValue":2.03,"strValue":null,"type":"PH"},{"numValue":41.47,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"K2HPO4, NaH2PO4","type":"BUFFER"},{"numValue":null,"strValue":"1.05 M, 1.26 M"...
[{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":27419,"numValue":-0.15,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27420,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2792
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,792
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
8,069
ProTherm
2
CD
Thermal
HCl
40.8
KCl
0.20 M
2LZM_A:V131A
null
null
null
-0.26
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
314
ARTICLE
Toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in T4 lysozyme.
1,991
10.1021/bi00222a001
1998663
Biochemistry;30;2012-7
3
Baase W A|Zhang X J|Matthews B W
[{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":40.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"HCl","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue...
[{"datasets":["capriotti_S1615_map.csv"],"id":27453,"numValue":-0.26,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27454,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2793
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,793
train
mutant
334
41
372
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A
V131A
1
1
0
0
131
V
A
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
8,071
ProTherm
2.02
CD
Thermal
Unknown
40.75
KCl
0.2 M
2LZM_A:V131A
null
null
null
-0.27
null
2.4
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
63
ARTICLE
Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability.
1,992
10.1002/pro.5560010608
1304917
Protein Sci;1;761-76
3
Baase W A|Zhang X J|Matthews B W
[{"numValue":2.02,"strValue":null,"type":"PH"},{"numValue":40.75,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"nu...
[{"datasets":[],"id":27458,"numValue":2.4,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv"],"id":27459,"numValue":-0.27,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27460,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2794
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,794
train
mutant
565
41
616
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131L
V131L
1
1
0
0
131
V
L
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
950
ProTherm
3.01
CD
Thermal
KH2PO4,H3PO4,
17 mM,3 mM,
null
KCl
25 mM
2LZM_A:V131L
53.31
0.23
null
null
null
null
121
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4,H3PO4,","type":"BUFFER"},{"numValue":null,"strValue":"17 mM,3 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"...
[{"datasets":[],"id":3561,"numValue":53.31,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3562,"numValue":0.23,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3563,"numValue":121.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2795
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,795
train
mutant
565
41
616
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131L
V131L
1
1
0
0
131
V
L
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
7,388
ProTherm
3.01
CD
Thermal
KH2PO4, H3PO4
17 mM, 3 mM
53.08
KCl
25 mM
2LZM_A:V131L
null
null
null
-0.09
null
2.4
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":53.08,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4, H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"17 mM, 3 mM","typ...
[{"datasets":[],"id":25730,"numValue":2.4,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":25731,"numValue":-0.09,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":25732,"numValue":null,"referenc...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2796
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,796
train
mutant
566
41
617
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131M
V131M
1
1
0
0
131
V
M
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
951
ProTherm
3.01
CD
Thermal
KH2PO4,H3PO4,
17 mM,3 mM,
null
KCl
25 mM
2LZM_A:V131M
53.4
0.32
null
null
null
null
126
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4,H3PO4,","type":"BUFFER"},{"numValue":null,"strValue":"17 mM,3 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"...
[{"datasets":[],"id":3565,"numValue":53.4,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3566,"numValue":0.32,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3567,"numValue":126.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2797
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,797
train
mutant
566
41
617
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131M
V131M
1
1
0
0
131
V
M
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
7,389
ProTherm
3.01
CD
Thermal
KH2PO4, H3PO4
17 mM, 3 mM
53.08
KCl
25 mM
2LZM_A:V131M
null
null
null
-0.12
null
2.4
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":53.08,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4, H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"17 mM, 3 mM","typ...
[{"datasets":[],"id":25733,"numValue":2.4,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":25734,"numValue":-0.12,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":25735,"numValue":null,"referenc...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2798
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,798
train
mutant
567
41
618
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131I
V131I
1
1
0
0
131
V
I
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
952
ProTherm
3.01
CD
Thermal
KH2PO4,H3PO4,
17 mM,3 mM,
null
KCl
25 mM
2LZM_A:V131I
53.49
0.41
null
null
null
null
127
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4,H3PO4,","type":"BUFFER"},{"numValue":null,"strValue":"17 mM,3 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"...
[{"datasets":[],"id":3569,"numValue":53.49,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3570,"numValue":0.41,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3571,"numValue":127.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2799
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,799
train
mutant
567
41
618
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131I
V131I
1
1
0
0
131
V
I
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
7,390
ProTherm
3.01
CD
Thermal
KH2PO4, H3PO4
17 mM, 3 mM
53.08
KCl
25 mM
2LZM_A:V131I
null
null
null
-0.16
null
2.4
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":53.08,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4, H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"17 mM, 3 mM","typ...
[{"datasets":[],"id":25736,"numValue":2.4,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":25737,"numValue":-0.16,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":25738,"numValue":null,"referenc...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2800
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,800
train
mutant
568
41
619
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131T
V131T
1
1
0
0
131
V
T
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
953
ProTherm
3.01
CD
Thermal
KH2PO4,H3PO4,
17 mM,3 mM,
null
KCl
25 mM
2LZM_A:V131T
52.75
-0.33
null
null
null
null
122
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4,H3PO4,","type":"BUFFER"},{"numValue":null,"strValue":"17 mM,3 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"...
[{"datasets":[],"id":3573,"numValue":52.75,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3574,"numValue":-0.33,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3575,"numValue":122.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[]...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2801
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,801
train
mutant
568
41
619
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131T
V131T
1
1
0
0
131
V
T
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
994
ProTherm
2.03
CD
Thermal
Unknown
null
KCl
0.2 M
2LZM_A:V131T
41.06
-0.41
null
null
null
null
82.4
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
103
ARTICLE
A mutant T4 lysozyme (Val 131----Ala) designed to increase thermostability by the reduction of strain within an alpha-helix.
1,990
10.1002/prot.340070208
2326253
Proteins;7;198-204
3
Baase W A|Matthews B W|Dao-Pin S
[{"numValue":2.03,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue":null,"strValue":"0.2 M","type":"ION_CONC"},{"numValu...
[{"datasets":[],"id":3725,"numValue":41.06,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3726,"numValue":-0.41,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3727,"numValue":82.4,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2802
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,802
train
mutant
568
41
619
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131T
V131T
1
1
0
0
131
V
T
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
997
ProTherm
2.83
CD
Thermal
Unknown
null
KCl
0.2 M
2LZM_A:V131T
50.95
-0.1
null
null
null
null
106.3
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
103
ARTICLE
A mutant T4 lysozyme (Val 131----Ala) designed to increase thermostability by the reduction of strain within an alpha-helix.
1,990
10.1002/prot.340070208
2326253
Proteins;7;198-204
3
Baase W A|Matthews B W|Dao-Pin S
[{"numValue":2.83,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue":null,"strValue":"0.2 M","type":"ION_CONC"},{"numValu...
[{"datasets":[],"id":3737,"numValue":50.95,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3738,"numValue":-0.1,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3739,"numValue":106.3,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2804
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,804
train
mutant
568
41
619
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131T
V131T
1
1
0
0
131
V
T
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
7,612
ProTherm
2.83
CD
Thermal
K2HPO4, NaH2PO4
1.05 M, 1.26 M
51.1
KCl
0.2 M
2LZM_A:V131T
null
null
null
0.05
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
103
ARTICLE
A mutant T4 lysozyme (Val 131----Ala) designed to increase thermostability by the reduction of strain within an alpha-helix.
1,990
10.1002/prot.340070208
2326253
Proteins;7;198-204
3
Baase W A|Matthews B W|Dao-Pin S
[{"numValue":2.83,"strValue":null,"type":"PH"},{"numValue":51.1,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"K2HPO4, NaH2PO4","type":"BUFFER"},{"numValue":null,"strValue":"1.05 M, 1.26 M",...
[{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":26289,"numValue":0.05,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26290,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2805
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,805
train
mutant
568
41
619
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131T
V131T
1
1
0
0
131
V
T
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
8,053
ProTherm
2.03
CD
Thermal
K2HPO4, NaH2PO4
1.05 M, 1.26 M
41.47
KCl
0.2 M
2LZM_A:V131T
null
null
null
0.11
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
103
ARTICLE
A mutant T4 lysozyme (Val 131----Ala) designed to increase thermostability by the reduction of strain within an alpha-helix.
1,990
10.1002/prot.340070208
2326253
Proteins;7;198-204
3
Baase W A|Matthews B W|Dao-Pin S
[{"numValue":2.03,"strValue":null,"type":"PH"},{"numValue":41.47,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"K2HPO4, NaH2PO4","type":"BUFFER"},{"numValue":null,"strValue":"1.05 M, 1.26 M"...
[{"datasets":["capriotti_S1615_map.csv"],"id":27421,"numValue":0.11,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27422,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2806
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,806
train
mutant
569
41
620
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131E
V131E
1
1
0
0
131
V
E
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
954
ProTherm
3.01
CD
Thermal
KH2PO4,H3PO4,
17 mM,3 mM,
null
KCl
25 mM
2LZM_A:V131E
53.6
0.52
null
null
null
null
128
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4,H3PO4,","type":"BUFFER"},{"numValue":null,"strValue":"17 mM,3 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"...
[{"datasets":[],"id":3577,"numValue":53.6,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3578,"numValue":0.52,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3579,"numValue":128.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2808
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,808
train
mutant
570
41
621
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131S
V131S
1
1
0
0
131
V
S
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
955
ProTherm
3.01
CD
Thermal
KH2PO4,H3PO4,
17 mM,3 mM,
null
KCl
25 mM
2LZM_A:V131S
52.96
-0.12
null
null
null
null
124
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4,H3PO4,","type":"BUFFER"},{"numValue":null,"strValue":"17 mM,3 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"...
[{"datasets":[],"id":3581,"numValue":52.96,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3582,"numValue":-0.12,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3583,"numValue":124.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[]...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2809
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,809
train
mutant
570
41
621
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131S
V131S
1
1
0
0
131
V
S
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
7,393
ProTherm
3.01
CD
Thermal
KH2PO4, H3PO4
17 mM, 3 mM
53.08
KCl
25 mM
2LZM_A:V131S
null
null
null
0.05
null
2.4
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":53.08,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4, H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"17 mM, 3 mM","typ...
[{"datasets":[],"id":25745,"numValue":2.4,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":25746,"numValue":0.05,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":25747,"numValue":null,"reference...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2810
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,810
train
mutant
571
41
622
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131D
V131D
1
1
0
0
131
V
D
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
956
ProTherm
3.01
CD
Thermal
KH2PO4,H3PO4,
17 mM,3 mM,
null
KCl
25 mM
2LZM_A:V131D
53.3
0.22
null
null
null
null
123
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4,H3PO4,","type":"BUFFER"},{"numValue":null,"strValue":"17 mM,3 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"...
[{"datasets":[],"id":3585,"numValue":53.3,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3586,"numValue":0.22,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3587,"numValue":123.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2811
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,811
train
mutant
571
41
622
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131D
V131D
1
1
0
0
131
V
D
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
7,394
ProTherm
3.01
CD
Thermal
KH2PO4, H3PO4
17 mM, 3 mM
53.08
KCl
25 mM
2LZM_A:V131D
null
null
null
-0.08
null
2.4
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":53.08,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4, H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"17 mM, 3 mM","typ...
[{"datasets":[],"id":25748,"numValue":2.4,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":25749,"numValue":-0.08,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":25750,"numValue":null,"referenc...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2812
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,812
train
mutant
572
41
623
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131G
V131G
1
1
0
0
131
V
G
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
957
ProTherm
3.01
CD
Thermal
KH2PO4,H3PO4,
17 mM,3 mM,
null
KCl
25 mM
2LZM_A:V131G
51.28
-1.8
null
null
null
null
123
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4,H3PO4,","type":"BUFFER"},{"numValue":null,"strValue":"17 mM,3 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"...
[{"datasets":[],"id":3589,"numValue":51.28,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3590,"numValue":-1.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3591,"numValue":123.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2813
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,813
train
mutant
572
41
623
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131G
V131G
1
1
0
0
131
V
G
2
CONSERVATION
1L63|2LZM
49|80
null
131
A
H
true
false
94.547905
19.562143
7,395
ProTherm
3.01
CD
Thermal
KH2PO4, H3PO4
17 mM, 3 mM
53.08
KCl
25 mM
2LZM_A:V131G
null
null
null
0.68
null
2.4
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
99
ARTICLE
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
1,994
10.1006/jmbi.1994.1016
8289284
J Mol Biol;235;600-24
6
Blaber M|Baase W A|Zhang X J|Matthews B W|Lindstrom J D|Pepiot S D
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":53.08,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4, H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"17 mM, 3 mM","typ...
[{"datasets":[],"id":25751,"numValue":2.4,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":25752,"numValue":0.68,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":25753,"num...
[{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2815
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,815
train
mutant
6,747
41
7,389
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A|N132A
V131A|N132A
2
2
0
0
131
V
A
2
BINDING_SITE|CONSERVATION
1L63|2LZM
49|80
null
131|132
A
H
true
false
68.516007
18.620759
14,719
ProTherm
2
CD
Thermal
HCl
null
KCl
0.20 M
2LZM_A:V131A 2LZM_A:N132A
43.1
2.3
null
null
null
null
82
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
314
ARTICLE
Toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in T4 lysozyme.
1,991
10.1021/bi00222a001
1998663
Biochemistry;30;2012-7
3
Baase W A|Zhang X J|Matthews B W
[{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"HCl","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue":null,"strValue":"0.20 M","type":"ION_CONC"},{"numValue":n...
[{"datasets":[],"id":54427,"numValue":43.1,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":54428,"numValue":2.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":54429,"numValue":82.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":54430,"numValue":null,"references":[...
[{"id":23,"numValue":null,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6923,"numValue":6.0,"position":132,"positionArray":null,"positionRange...
fireprotdb:2816
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,816
train
mutant
6,747
41
7,389
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A|N132A
V131A|N132A
2
2
0
0
131
V
A
2
BINDING_SITE|CONSERVATION
1L63|2LZM
49|80
null
131|132
A
H
true
false
68.516007
18.620759
15,100
ProTherm
2
CD
Thermal
HCl
40.8
KCl
0.20 M
2LZM_A:V131A 2LZM_A:N132A
null
null
null
-0.62
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
314
ARTICLE
Toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in T4 lysozyme.
1,991
10.1021/bi00222a001
1998663
Biochemistry;30;2012-7
3
Baase W A|Zhang X J|Matthews B W
[{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":40.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"HCl","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue...
[{"datasets":[],"id":55415,"numValue":-0.62,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55416,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":23,"numValue":null,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6923,"numValue":6.0,"position":132,"positionArray":null,"positionRange...
fireprotdb:2817
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,817
train
mutant
6,747
41
7,389
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
V131A|N132A
V131A|N132A
2
2
0
0
131
V
A
2
BINDING_SITE|CONSERVATION
1L63|2LZM
49|80
null
131|132
A
H
true
false
68.516007
18.620759
15,104
ProTherm
2.02
CD
Thermal
Unknown
40.75
KCl
0.2 M
2LZM_A:V131A 2LZM_A:N132A
null
null
null
-0.57
null
2.4
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
63
ARTICLE
Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability.
1,992
10.1002/pro.5560010608
1304917
Protein Sci;1;761-76
3
Baase W A|Zhang X J|Matthews B W
[{"numValue":2.02,"strValue":null,"type":"PH"},{"numValue":40.75,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"nu...
[{"datasets":[],"id":55425,"numValue":2.4,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55426,"numValue":-0.57,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55427,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":23,"numValue":null,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":6922,"numValue":2.0,"position":131,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6923,"numValue":6.0,"position":132,"positionArray":null,"positionRange...
fireprotdb:2818
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,818
train
mutant
538
41
589
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N132M
N132M
1
1
0
0
132
N
M
6
BINDING_SITE|CONSERVATION
1L63|2LZM
49|80
null
132
A
H
true
false
42.48411
17.679375
921
ProTherm
5.4
CD
Thermal
Acetic acid,Sodium acetate,
1.4 mM,8.6 mM,
null
NaCl
100 mM
2LZM_A:N132M
70.08
3.6
null
null
null
3.5
134
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DCP|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
98
ARTICLE
A relationship between protein stability and protein function.
1,995
10.1073/pnas.92.2.452
7831309
Proc Natl Acad Sci U S A;92;452-6
4
Kuroki R|Baase W A|Matthews B W|Shoichet B K
[{"numValue":5.4,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid,Sodium acetate,","type":"BUFFER"},{"numValue":null,"strValue":"1.4 mM,8.6 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue...
[{"datasets":[],"id":3436,"numValue":70.08,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3437,"numValue":3.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3438,"numValue":3.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id"...
[{"id":23,"numValue":null,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":6923,"numValue":6.0,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2819
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,819
train
mutant
538
41
589
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N132M
N132M
1
1
0
0
132
N
M
6
BINDING_SITE|CONSERVATION
1L63|2LZM
49|80
null
132
A
H
true
false
42.48411
17.679375
6,736
ProTherm
5.4
CD
Thermal
Acetic acid, Sodium acetate
1.4 mM, 8.6 mM
66.48
NaCl
100 mM
2LZM_A:N132M
null
null
null
-1.5
null
3.5
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
98
ARTICLE
A relationship between protein stability and protein function.
1,995
10.1073/pnas.92.2.452
7831309
Proc Natl Acad Sci U S A;92;452-6
4
Kuroki R|Baase W A|Matthews B W|Shoichet B K
[{"numValue":5.4,"strValue":null,"type":"PH"},{"numValue":66.48,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid, Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"1.4 ...
[{"datasets":[],"id":23930,"numValue":3.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":23931,"numValue":-1.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":23932,"numValue":null,"reference...
[{"id":23,"numValue":null,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":6923,"numValue":6.0,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2820
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,820
train
mutant
539
41
590
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N132F
N132F
1
1
0
0
132
N
F
6
BINDING_SITE|CONSERVATION
1L63|2LZM
49|80
null
132
A
H
true
false
42.48411
17.679375
922
ProTherm
5.4
CD
Thermal
Acetic acid,Sodium acetate,
1.4 mM,8.6 mM,
null
NaCl
100 mM
2LZM_A:N132F
69.78
3.3
null
null
null
3.5
134
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DCP|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv|AUTOMUTE_S1925.csv|EASE-MM_S1676.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S2760.csv|Saraboji_S1396.csv|STRUM_Q3421.csv|SVM-WIN31_SVM-3D12_S1634.csv|SVM-WIN31_SVM-3D12_S1681.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
98
ARTICLE
A relationship between protein stability and protein function.
1,995
10.1073/pnas.92.2.452
7831309
Proc Natl Acad Sci U S A;92;452-6
4
Kuroki R|Baase W A|Matthews B W|Shoichet B K
[{"numValue":5.4,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid,Sodium acetate,","type":"BUFFER"},{"numValue":null,"strValue":"1.4 mM,8.6 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue...
[{"datasets":[],"id":3441,"numValue":69.78,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3442,"numValue":3.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":["AUTOMUTE_S1925.csv","EASE-MM_S1676.csv","I_Mutant2.0_S1948.csv","I_Mutant2.0_S2087.csv","iP...
[{"id":23,"numValue":null,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":6923,"numValue":6.0,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2821
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,821
train
mutant
539
41
590
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N132F
N132F
1
1
0
0
132
N
F
6
BINDING_SITE|CONSERVATION
1L63|2LZM
49|80
null
132
A
H
true
false
42.48411
17.679375
6,737
ProTherm
5.4
CD
Thermal
Acetic acid, Sodium acetate
1.4 mM, 8.6 mM
66.48
NaCl
100 mM
2LZM_A:N132F
null
null
null
-1.3
null
3.5
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
98
ARTICLE
A relationship between protein stability and protein function.
1,995
10.1073/pnas.92.2.452
7831309
Proc Natl Acad Sci U S A;92;452-6
4
Kuroki R|Baase W A|Matthews B W|Shoichet B K
[{"numValue":5.4,"strValue":null,"type":"PH"},{"numValue":66.48,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid, Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"1.4 ...
[{"datasets":[],"id":23933,"numValue":3.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":23934,"numValue":-1.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":23935,"numValue":null,"reference...
[{"id":23,"numValue":null,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":6923,"numValue":6.0,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2823
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,823
train
mutant
540
41
591
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N132I
N132I
1
1
0
0
132
N
I
6
BINDING_SITE|CONSERVATION
1L63|2LZM
49|80
null
132
A
H
true
false
42.48411
17.679375
6,738
ProTherm
5.4
CD
Thermal
Acetic acid, Sodium acetate
1.4 mM, 8.6 mM
66.48
NaCl
100 mM
2LZM_A:N132I
null
null
null
-1.2
null
3.5
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
98
ARTICLE
A relationship between protein stability and protein function.
1,995
10.1073/pnas.92.2.452
7831309
Proc Natl Acad Sci U S A;92;452-6
4
Kuroki R|Baase W A|Matthews B W|Shoichet B K
[{"numValue":5.4,"strValue":null,"type":"PH"},{"numValue":66.48,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid, Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"1.4 ...
[{"datasets":[],"id":23936,"numValue":3.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":23937,"numValue":-1.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":23938,"numValue":null,"reference...
[{"id":23,"numValue":null,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":6923,"numValue":6.0,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2824
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,824
train
mutant
42
41
46
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133A
L133A
1
1
0
0
133
L
A
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
42
ProTherm
3.01
CD
Thermal
Potassium phosphate
0.020 M
null
KCl
0.025 M
2LZM_A:L133A
42.9
-8.9
null
null
null
2.5
91.5
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DCP|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
5
ARTICLE
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect.
1,992
10.1126/science.1553543
1553543
Science;255;178-83
5
Blaber M|Eriksson A E|Baase W A|Zhang X J|Heinz D W
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"0.020 M","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type"...
[{"datasets":[],"id":141,"numValue":42.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":142,"numValue":-8.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":143,"numValue":2.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":14...
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2825
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,825
train
mutant
42
41
46
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133A
L133A
1
1
0
0
133
L
A
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
584
ProTherm
2.02
CD
Thermal
Unknown
null
KCl
0.2 M
2LZM_A:L133A
23.75
-17
null
null
null
2.4
53
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DCP|DHVH|REVERSIBILITY
M47andM8_S2760.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv
MEASURE|PH|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
63
ARTICLE
Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability.
1,992
10.1002/pro.5560010608
1304917
Protein Sci;1;761-76
3
Baase W A|Zhang X J|Matthews B W
[{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":2.02,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue":null,"strValue":"0.2 M","type":"ION_CONC"},{"numValu...
[{"datasets":["M47andM8_S2760.csv"],"id":2325,"numValue":23.75,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":2326,"numValue":-17.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":2327,"numValue":2.4,"references":[],"strValue":null,"type":"DCP...
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2826
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,826
train
mutant
42
41
46
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133A
L133A
1
1
0
0
133
L
A
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
7,503
ProTherm
3.01
CD
Thermal
Potassium phosphate
0.020 M
51.8
KCl
0.025 M
2LZM_A:L133A
null
null
null
4.3
null
2.5
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|guerios_625_map.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
5
ARTICLE
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect.
1,992
10.1126/science.1553543
1553543
Science;255;178-83
5
Blaber M|Eriksson A E|Baase W A|Zhang X J|Heinz D W
[{"numValue":3.01,"strValue":null,"type":"PH"},{"numValue":51.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"0.020 M","ty...
[{"datasets":[],"id":26006,"numValue":2.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","potapov_with_uniprot_mapping.csv"],"id":26007,"numValue":4.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26008,"numValue":null,"references":[],"strV...
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2827
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,827
train
mutant
42
41
46
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133A
L133A
1
1
0
0
133
L
A
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
8,072
ProTherm
2.02
CD
Thermal
Unknown
40.75
KCl
0.2 M
2LZM_A:L133A
null
null
null
4.19
null
2.4
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
63
ARTICLE
Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability.
1,992
10.1002/pro.5560010608
1304917
Protein Sci;1;761-76
3
Baase W A|Zhang X J|Matthews B W
[{"numValue":2.02,"strValue":null,"type":"PH"},{"numValue":40.75,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"nu...
[{"datasets":[],"id":27461,"numValue":2.4,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":27462,"numValue":4.19,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27463,"numValue":null,"references":[],"strValue":"yes","type":"REVE...
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2828
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,828
train
mutant
168
41
196
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133M
L133M
1
1
0
0
133
L
M
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
305
ProTherm
5.42
CD
Thermal
Acetic acid,Sodium acetate,
1.4 mM,8.6 mM,
null
NaCl
0.1 M
2LZM_A:L133M
64.3
-1
null
null
null
2.5
128
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DCP|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
33
ARTICLE
A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme.
1,996
10.1073/pnas.93.22.12155
8901549
Proc Natl Acad Sci U S A;93;12155-8
3
Baase W A|Matthews B W|Gassner N C
[{"numValue":5.42,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid,Sodium acetate,","type":"BUFFER"},{"numValue":null,"strValue":"1.4 mM,8.6 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValu...
[{"datasets":[],"id":1250,"numValue":64.3,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":1251,"numValue":-1.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":1252,"numValue":2.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id"...
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2829
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,829
train
mutant
168
41
196
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133M
L133M
1
1
0
0
133
L
M
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
6,776
ProTherm
5.42
CD
Thermal
Acetic acid,Sodium acetate
1.4 mM,8.6 mM
65.3
NaCl
0.1 M
2LZM_A:L133M
null
null
null
0.4
null
2.5
null
null
null
null
null
null
null
null
null
null
Unknown
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
33
ARTICLE
A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme.
1,996
10.1073/pnas.93.22.12155
8901549
Proc Natl Acad Sci U S A;93;12155-8
3
Baase W A|Matthews B W|Gassner N C
[{"numValue":5.42,"strValue":null,"type":"PH"},{"numValue":65.3,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid,Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"1.4 m...
[{"datasets":[],"id":24030,"numValue":2.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":24031,"numValue":0.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":24032,"numValue":null,"references...
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2830
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,830
train
mutant
340
41
379
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133D
L133D
1
1
0
0
133
L
D
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
596
ProTherm
3
CD
Thermal
Potassium phosphate
20 mM
null
KCl
25 mM
2LZM_A:L133D
36.7
-14.9
null
null
null
1.8
47.9
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DCP|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
65
ARTICLE
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme.
1,991
10.1021/bi00113a006
1747370
Biochemistry;30;11521-9
5
Baase W A|Matthews B W|Dao-pin S|Anderson D E|Dahlquist F W
[{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"I...
[{"datasets":[],"id":2365,"numValue":36.7,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":2366,"numValue":-14.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":2367,"numValue":1.8,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id...
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2832
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,832
train
mutant
340
41
379
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133D
L133D
1
1
0
0
133
L
D
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
599
ProTherm
6.5
CD
Thermal
Potassium phosphate
20 mM
null
KCl
25 mM
2LZM_A:L133D
44
-17.9
null
null
null
1.8
50.8
null
null
null
null
null
null
null
null
null
yes(50-75%)
TM|DTM|DCP|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
65
ARTICLE
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme.
1,991
10.1021/bi00113a006
1747370
Biochemistry;30;11521-9
5
Baase W A|Matthews B W|Dao-pin S|Anderson D E|Dahlquist F W
[{"numValue":6.5,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"I...
[{"datasets":[],"id":2380,"numValue":44.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":2381,"numValue":-17.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":2382,"numValue":1.8,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id...
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2833
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,833
train
mutant
340
41
379
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133D
L133D
1
1
0
0
133
L
D
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
601
ProTherm
10.4
CD
Thermal
Potassium phosphate
20 mM
null
KCl
25 mM
2LZM_A:L133D
28.9
-19
null
null
null
1.8
47.1
null
null
null
null
null
null
null
null
null
yes(20%)
TM|DTM|DCP|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv|AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
65
ARTICLE
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme.
1,991
10.1021/bi00113a006
1747370
Biochemistry;30;11521-9
5
Baase W A|Matthews B W|Dao-pin S|Anderson D E|Dahlquist F W
[{"numValue":10.4,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"...
[{"datasets":[],"id":2390,"numValue":28.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":2391,"numValue":-19.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":2392,"numValue":1.8,"refe...
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2834
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,834
train
mutant
340
41
379
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133D
L133D
1
1
0
0
133
L
D
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
7,005
ProTherm
4.4
CD
Thermal
Potassium phosphate
20 mM
64.6
KCl
25 mM
2LZM_A:L133D
null
null
null
5.5
null
1.8
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
65
ARTICLE
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme.
1,991
10.1021/bi00113a006
1747370
Biochemistry;30;11521-9
5
Baase W A|Matthews B W|Dao-pin S|Anderson D E|Dahlquist F W
[{"numValue":4.4,"strValue":null,"type":"PH"},{"numValue":64.6,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type"...
[{"datasets":[],"id":24656,"numValue":1.8,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv"],"id":24657,"numValue":5.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":24658,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2835
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,835
train
mutant
340
41
379
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133D
L133D
1
1
0
0
133
L
D
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
7,075
ProTherm
6.5
CD
Thermal
Potassium phosphate
20 mM
61.9
KCl
25 mM
2LZM_A:L133D
null
null
null
5.7
null
1.8
null
null
null
null
null
null
null
null
null
null
yes(50-75%)
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
65
ARTICLE
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme.
1,991
10.1021/bi00113a006
1747370
Biochemistry;30;11521-9
5
Baase W A|Matthews B W|Dao-pin S|Anderson D E|Dahlquist F W
[{"numValue":6.5,"strValue":null,"type":"PH"},{"numValue":61.9,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type"...
[{"datasets":[],"id":24824,"numValue":1.8,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv"],"id":24825,"numValue":5.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":24826,"numValue":null,"references":[],"strValue":"yes(50-75%)","type":"REVERSIBILITY"}]
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2836
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,836
train
mutant
340
41
379
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133D
L133D
1
1
0
0
133
L
D
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
7,581
ProTherm
3
CD
Thermal
Potassium phosphate
20 mM
51.6
KCl
25 mM
2LZM_A:L133D
null
null
null
4.9
null
1.8
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
65
ARTICLE
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme.
1,991
10.1021/bi00113a006
1747370
Biochemistry;30;11521-9
5
Baase W A|Matthews B W|Dao-pin S|Anderson D E|Dahlquist F W
[{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":51.6,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type"...
[{"datasets":[],"id":26216,"numValue":1.8,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":26217,"numValue":4.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26218,"numValue":null,"references":[],"strValue":"yes","type":"REVER...
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2837
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,837
train
mutant
434
41
480
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133F
L133F
1
1
0
0
133
L
F
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
707
ProTherm
1.99
CD
Thermal
Unknown
null
KCl
0.2 M
2LZM_A:L133F
40.7
-0.7
null
null
null
null
83
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv|AUTOMUTE_S1925.csv|EASE-MM_S1676.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S2760.csv|PoPMuSiC-2.0_S2648.csv|Saraboji_S1396.csv|STRUM_Q3421.csv|SVM-WIN31_SVM-3D12_S1634.csv|SVM-WIN31_SVM-3D12_S1681.csv
PH|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
79
ARTICLE
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants.
1,989
10.1073/pnas.86.21.8237
2682639
Proc Natl Acad Sci U S A;86;8237-41
4
Baase W A|Matthews B W|Matsumura M|Karpusas M
[{"numValue":1.99,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue":null,"strValue":"0.2 M","type":"ION_CONC"},{"numValu...
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fireprotdb:2838
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,838
train
mutant
434
41
480
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133F
L133F
1
1
0
0
133
L
F
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
709
ProTherm
2.86
CD
Thermal
Unknown
null
KCl
0.2 M
2LZM_A:L133F
51.3
-0.8
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
79
ARTICLE
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants.
1,989
10.1073/pnas.86.21.8237
2682639
Proc Natl Acad Sci U S A;86;8237-41
4
Baase W A|Matthews B W|Matsumura M|Karpusas M
[{"numValue":2.86,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue":null,"strValue":"0.2 M","type":"ION_CONC"},{"numValu...
[{"datasets":[],"id":2752,"numValue":51.3,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":2753,"numValue":-0.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":2754,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2839
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,839
train
mutant
434
41
480
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133F
L133F
1
1
0
0
133
L
F
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
1,429
ProTherm
5.35
CD
Thermal
sodium chloride, acetic acid, sodium acetate
0.10 M, 1.4 mM, 8.6 mM
null
2LZM_A:L133F
64.8
-0.7
null
null
null
null
130
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
151
ARTICLE
Repacking the Core of T4 lysozyme by automated design.
2,003
10.1016/s0022-2836(03)00856-8
12963380
J Mol Biol;332;741-56
6
Mooers Blaine H M|Datta Deepshikha|Baase Walter A|Zollars Eric S|Mayo Stephen L|Matthews Brian W
[{"numValue":5.35,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium chloride, acetic acid, sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"0.10 M, 1.4 mM, 8.6 mM","type":"BUFFER_CONC"},...
[{"datasets":[],"id":5219,"numValue":64.8,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":5220,"numValue":-0.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":5221,"numValue":130.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"...
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2840
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,840
train
mutant
434
41
480
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133F
L133F
1
1
0
0
133
L
F
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
7,085
ProTherm
5.35
CD
Thermal
sodium chloride, acetic acid, sodium acetate
0.10 M, 1.4 mM, 8.6 mM
61
2LZM_A:L133F
null
null
null
0.3
null
2.5
null
null
null
null
null
null
null
null
null
null
Unknown
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
151
ARTICLE
Repacking the Core of T4 lysozyme by automated design.
2,003
10.1016/s0022-2836(03)00856-8
12963380
J Mol Biol;332;741-56
6
Mooers Blaine H M|Datta Deepshikha|Baase Walter A|Zollars Eric S|Mayo Stephen L|Matthews Brian W
[{"numValue":5.35,"strValue":null,"type":"PH"},{"numValue":61.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium chloride, acetic acid, sodium acetate","type":"BUFFER"},{"numValue":null...
[{"datasets":[],"id":24854,"numValue":2.5,"references":[],"strValue":null,"type":"DCP"},{"datasets":["capriotti_S1615_map.csv","potapov_with_uniprot_mapping.csv"],"id":24855,"numValue":0.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":24856,"numValue":null,"references":[],"strValue":"Unknown","type"...
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2841
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,841
train
mutant
434
41
480
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133F
L133F
1
1
0
0
133
L
F
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
7,462
ProTherm
2.86
CD
Thermal
Unknown
52.1
KCl
0.2 M
2LZM_A:L133F
null
null
null
0.3
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
79
ARTICLE
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants.
1,989
10.1073/pnas.86.21.8237
2682639
Proc Natl Acad Sci U S A;86;8237-41
4
Baase W A|Matthews B W|Matsumura M|Karpusas M
[{"numValue":2.86,"strValue":null,"type":"PH"},{"numValue":52.1,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"num...
[{"datasets":["capriotti_S1615_map.csv","potapov_with_uniprot_mapping.csv"],"id":25920,"numValue":0.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":25921,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2842
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,842
train
mutant
434
41
480
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
L133F
L133F
1
1
0
0
133
L
F
7
CONSERVATION
1L63|2LZM
49|80
null
133
A
H
true
false
1.679637
15.7625
8,055
ProTherm
1.99
CD
Thermal
Unknown
41.4
KCl
0.2 M
2LZM_A:L133F
null
null
null
0.2
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
79
ARTICLE
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants.
1,989
10.1073/pnas.86.21.8237
2682639
Proc Natl Acad Sci U S A;86;8237-41
4
Baase W A|Matthews B W|Matsumura M|Karpusas M
[{"numValue":1.99,"strValue":null,"type":"PH"},{"numValue":41.4,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"KCl","type":"ION"},{"num...
[{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27425,"numValue":0.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27426,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6924,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2843
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,843
train
mutant
237
41
267
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A134S
A134S
1
1
0
0
134
A
S
6
CONSERVATION
1L63|2LZM
49|80
null
134
A
H
true
false
29.453611
17.493
423
ProTherm
3
CD
Thermal
Potassium phosphate
20 mM
null
KCl
25 mM
2LZM_A:A134S
51.11
-0.44
null
null
null
null
111
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
44
ARTICLE
Energetic cost and structural consequences of burying a hydroxyl group within the core of a protein determined from Ala-->Ser and Val-->Thr substitutions in T4 lysozyme.
1,993
10.1021/bi00093a013
8218201
Biochemistry;32;11363-73
6
Xu J|Blaber M|Gassner N|Heinz D W|Matthews B W|Lindstrom J D
[{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"I...
[{"datasets":[],"id":1743,"numValue":51.11,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":1744,"numValue":-0.44,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":1745,"numValue":111.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[]...
[{"id":6925,"numValue":6.0,"position":134,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2844
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,844
train
mutant
237
41
267
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
A134S
A134S
1
1
0
0
134
A
S
6
CONSERVATION
1L63|2LZM
49|80
null
134
A
H
true
false
29.453611
17.493
7,592
ProTherm
3
CD
Thermal
Potassium phosphate
20 mM
51.55
KCl
25 mM
2LZM_A:A134S
null
null
null
0.1
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
44
ARTICLE
Energetic cost and structural consequences of burying a hydroxyl group within the core of a protein determined from Ala-->Ser and Val-->Thr substitutions in T4 lysozyme.
1,993
10.1021/bi00093a013
8218201
Biochemistry;32;11363-73
6
Xu J|Blaber M|Gassner N|Heinz D W|Matthews B W|Lindstrom J D
[{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":51.55,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type...
[{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":26241,"numValue":0.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26242,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6925,"numValue":6.0,"position":134,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2845
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,845
train
mutant
57
41
63
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
K135E
K135E
1
1
0
0
135
K
E
5
CONSERVATION
1L63|2LZM
49|80
null
135
A
S
true
false
146.699309
30.577222
71
ProTherm
2.8
CD
Thermal
Potassium phosphate
20 mM
null
KCl
25 mM
2LZM_A:K135E
50.2
-0.7
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv|HotMuSiC_S1626.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
8
ARTICLE
Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability.
1,991
10.1016/0022-2836(91)80181-s
1942034
J Mol Biol;221;873-87
5
Baase W A|Dao-pin S|S?derlind E|Wozniak J A|Sauer U
[{"numValue":2.8,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"I...
[{"datasets":[],"id":242,"numValue":50.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":243,"numValue":-0.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":["HotMuSiC_S1626.csv"],"id":244,"numValue":null,"references":[],"strValue":"yes","type":"REVERS...
[{"id":6926,"numValue":5.0,"position":135,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2846
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,846
train
mutant
57
41
63
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
K135E
K135E
1
1
0
0
135
K
E
5
CONSERVATION
1L63|2LZM
49|80
null
135
A
S
true
false
146.699309
30.577222
76
ProTherm
5.3
CD
Thermal
Potassium phosphate
20 mM
null
KCl
25 mM
2LZM_A:K135E
64.4
-2.3
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
8
ARTICLE
Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability.
1,991
10.1016/0022-2836(91)80181-s
1942034
J Mol Biol;221;873-87
5
Baase W A|Dao-pin S|S?derlind E|Wozniak J A|Sauer U
[{"numValue":5.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"I...
[{"datasets":[],"id":257,"numValue":64.4,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":258,"numValue":-2.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":259,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6926,"numValue":5.0,"position":135,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2847
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,847
train
mutant
57
41
63
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
K135E
K135E
1
1
0
0
135
K
E
5
CONSERVATION
1L63|2LZM
49|80
null
135
A
S
true
false
146.699309
30.577222
6,712
ProTherm
5.3
CD
Thermal
Potassium phosphate
20 mM
66.7
KCl
25 mM
2LZM_A:K135E
null
null
null
1
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
8
ARTICLE
Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability.
1,991
10.1016/0022-2836(91)80181-s
1942034
J Mol Biol;221;873-87
5
Baase W A|Dao-pin S|S?derlind E|Wozniak J A|Sauer U
[{"numValue":5.3,"strValue":null,"type":"PH"},{"numValue":66.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type"...
[{"datasets":["capriotti_S1615_map.csv"],"id":23867,"numValue":1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":23868,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6926,"numValue":5.0,"position":135,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2848
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,848
train
mutant
57
41
63
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
K135E
K135E
1
1
0
0
135
K
E
5
CONSERVATION
1L63|2LZM
49|80
null
135
A
S
true
false
146.699309
30.577222
7,616
ProTherm
2.8
CD
Thermal
Potassium phosphate
20 mM
50.9
KCl
25 mM
2LZM_A:K135E
null
null
null
0.2
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
8
ARTICLE
Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability.
1,991
10.1016/0022-2836(91)80181-s
1942034
J Mol Biol;221;873-87
5
Baase W A|Dao-pin S|S?derlind E|Wozniak J A|Sauer U
[{"numValue":2.8,"strValue":null,"type":"PH"},{"numValue":50.9,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type"...
[{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":26297,"numValue":0.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":26298,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6926,"numValue":5.0,"position":135,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2849
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,849
train
mutant
57
41
63
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
K135E
K135E
1
1
0
0
135
K
E
5
CONSERVATION
1L63|2LZM
49|80
null
135
A
S
true
false
146.699309
30.577222
11,154
ProTherm
5.3
CD
Thermal
Potassium phosphate
20 mM
25
KCl
25 mM
2LZM_A:K135E
null
null
null
1
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
750
ARTICLE
Charge-charge interactions influence the denatured state ensemble and contribute to protein stability.
2,000
10.1110/ps.9.7.1395
10933506
Protein Sci;9;1395-8
3
Pace C N|Shaw K L|Alston R W
[{"numValue":5.3,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type"...
[{"datasets":["capriotti_S1615_map.csv"],"id":38362,"numValue":1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":38363,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":6926,"numValue":5.0,"position":135,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2850
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,850
train
mutant
1,882
41
2,110
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
K135C
K135C
1
1
0
0
135
K
C
5
CONSERVATION
1L63|2LZM
49|80
null
135
A
S
true
false
146.699309
30.577222
3,627
ProTherm
2.4
CD
Thermal
Potassium phosphate
20 mM
null
KCl
25 mM
2LZM_A:K135C
33.8
-2.6
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Broom_S605.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
338
ARTICLE
Protein folding: assignment of the energetic changes of reversible chemical modifications to the folded or unfolded states.
1,992
10.1021/bi00149a004
1510962
Biochemistry;31;7765-72
4
Lu J|Baase W A|Dahlquist F W|Muchmore D C
[{"numValue":2.4,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"I...
[{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":13332,"numValue":33.8,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Broom_S605.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":13333,"numValue":-2.6,"references":...
[{"id":6926,"numValue":5.0,"position":135,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2852
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,852
train
mutant
6,704
41
7,346
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
K135E|K147E
K135E|K147E
2
2
0
0
135
K
E
5
CONSERVATION
1L63|2LZM
49|80
null
135|147
A
S|H
true
false
119.150183
30.829722
14,453
ProTherm
5.3
CD
Thermal
Potassium phosphate
20 mM
null
KCl
25 mM
2LZM_A:K135E 2LZM_A:K147E
63
-3.7
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
8
ARTICLE
Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability.
1,991
10.1016/0022-2836(91)80181-s
1942034
J Mol Biol;221;873-87
5
Baase W A|Dao-pin S|S?derlind E|Wozniak J A|Sauer U
[{"numValue":5.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"I...
[{"datasets":[],"id":53427,"numValue":63.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":53428,"numValue":-3.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":53429,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6926,"numValue":5.0,"position":135,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6938,"numValue":3.0,"position":147,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2853
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,853
train
mutant
6,704
41
7,346
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
K135E|K147E
K135E|K147E
2
2
0
0
135
K
E
5
CONSERVATION
1L63|2LZM
49|80
null
135|147
A
S|H
true
false
119.150183
30.829722
14,890
ProTherm
5.3
CD
Thermal
Potassium phosphate
20 mM
66.7
KCl
25 mM
2LZM_A:K135E 2LZM_A:K147E
null
null
null
1.5
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
8
ARTICLE
Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability.
1,991
10.1016/0022-2836(91)80181-s
1942034
J Mol Biol;221;873-87
5
Baase W A|Dao-pin S|S?derlind E|Wozniak J A|Sauer U
[{"numValue":5.3,"strValue":null,"type":"PH"},{"numValue":66.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type"...
[{"datasets":[],"id":54915,"numValue":1.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":54916,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6926,"numValue":5.0,"position":135,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6938,"numValue":3.0,"position":147,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2854
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,854
train
mutant
6,704
41
7,346
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
K135E|K147E
K135E|K147E
2
2
0
0
135
K
E
5
CONSERVATION
1L63|2LZM
49|80
null
135|147
A
S|H
true
false
119.150183
30.829722
15,037
ProTherm
2.8
CD
Thermal
Potassium phosphate
20 mM
50.9
KCl
25 mM
2LZM_A:K135E 2LZM_A:K147E
null
null
null
0.3
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
8
ARTICLE
Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability.
1,991
10.1016/0022-2836(91)80181-s
1942034
J Mol Biol;221;873-87
5
Baase W A|Dao-pin S|S?derlind E|Wozniak J A|Sauer U
[{"numValue":2.8,"strValue":null,"type":"PH"},{"numValue":50.9,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type"...
[{"datasets":[],"id":55263,"numValue":0.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55264,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6926,"numValue":5.0,"position":135,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":6938,"numValue":3.0,"position":147,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2855
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,855
train
mutant
132
41
150
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
W138Y
W138Y
1
1
0
0
138
W
Y
9
CONSERVATION
1L63|2LZM
49|80
null
138
A
H
true
true
14.821883
15.446786
244
ProTherm
2
CD
Thermal
Unknown
null
2LZM_A:W138Y
46.85
null
null
null
null
2.1
104
null
null
null
null
null
null
null
null
null
Unknown
TM|DCP|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION
22
ARTICLE
Mutations and protein stability.
1,981
10.1002/bip.1981.360200921
7306671
Biopolymers;20;1989-99
4
Lindorfer M|Hawkes R|Grutter M|Schellman J A
[{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"2LZM_A:W138Y","type":"_PDB_CHAIN_MUTATION"}]
[{"datasets":[],"id":998,"numValue":46.85,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":999,"numValue":2.1,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":1000,"numValue":104.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":1001,"numValue":null,"references":[],"s...
[{"id":6929,"numValue":9.0,"position":138,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2856
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,856
train
mutant
132
41
150
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
W138Y
W138Y
1
1
0
0
138
W
Y
9
CONSERVATION
1L63|2LZM
49|80
null
138
A
H
true
true
14.821883
15.446786
249
ProTherm
2
CD
Thermal
Unknown
null
2LZM_A:W138Y
34
-3
null
null
null
2.1
null
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DCP|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv|EASE-MM_S1676.csv|HotMuSiC_S1626.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S2760.csv|PON-TStab_dataset.csv|PoPMuSiC-2.0_S2648.csv|Saraboji_S1396.csv|STRUM_Q3421.csv|SVM-WIN31_SVM-3D12_S1634.csv|SVM-WIN31_SVM-3D12_S1681.csv
PH|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION
22
ARTICLE
Mutations and protein stability.
1,981
10.1002/bip.1981.360200921
7306671
Biopolymers;20;1989-99
4
Lindorfer M|Hawkes R|Grutter M|Schellman J A
[{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"2LZM_A:W138Y","type":"_PDB_CHAIN_MUTATION"}]
[{"datasets":[],"id":1018,"numValue":34.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":1019,"numValue":-3.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":1020,"numValue":2.1,"references":[],"strValue":null,"type":"DCP"},{"datasets":["EASE-...
[{"id":6929,"numValue":9.0,"position":138,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2859
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,859
train
mutant
132
41
150
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
W138Y
W138Y
1
1
0
0
138
W
Y
9
CONSERVATION
1L63|2LZM
49|80
null
138
A
H
true
true
14.821883
15.446786
12,618
ProTherm
7
Gel electrophoresis
Urea
imidazole,MOPS,
0.05 M,0.05 M,
22
2LZM_A:W138Y
null
null
null
2.87
null
null
null
4.9
null
null
null
null
null
null
null
null
Unknown
DDG|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
809
ARTICLE
Correlation between mutational destabilization of phage T4 lysozyme and increased unfolding rates.
1,991
10.1021/bi00216a038
1988046
Biochemistry;30;589-94
4
Alber T|Wozniak J A|Goldenberg D P|Klemm J D
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":22.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Gel electrophoresis","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"imidazole,MOPS,","type":"BUFFER"},{"numValue":null,"strValue":"0.0...
[{"datasets":["SAAFEC_S1262.csv"],"id":45757,"numValue":2.87,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":45758,"numValue":4.9,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":45759,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":6929,"numValue":9.0,"position":138,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2860
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,860
train
mutant
1,877
41
2,105
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
T142C
T142C
1
1
0
0
142
T
C
9
CONSERVATION
1L63|2LZM
49|80
null
142
A
S
true
true
25.225749
14.916429
3,621
ProTherm
2.4
CD
Thermal
Potassium phosphate
20 mM
null
KCl
25 mM
2LZM_A:T142C
35.9
-0.5
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1962.csv|Saraboji_S2204.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv|AUTOMUTE_S1925.csv|EASE-MM_S1676.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S1810.csv|M47andM8_S2760.csv|SVM-WIN31_SVM-3D12_S1634.csv|SVM-WIN31_SVM-3D12_S1681.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
338
ARTICLE
Protein folding: assignment of the energetic changes of reversible chemical modifications to the folded or unfolded states.
1,992
10.1021/bi00149a004
1510962
Biochemistry;31;7765-72
4
Lu J|Baase W A|Dahlquist F W|Muchmore D C
[{"numValue":2.4,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"I...
[{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":13314,"numValue":35.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv"],"id":13315,"numValue":-0.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":["AUTOMU...
[{"id":6933,"numValue":9.0,"position":142,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2861
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,861
train
mutant
1,600
41
1,800
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
P143A
P143A
1
1
0
0
143
P
A
5
CONSERVATION
1L63|2LZM
49|80
null
143
A
H
false
false
55.024902
16.895714
2,999
ProTherm
2
CD
Thermal
phosphate
50 mM
null
2LZM_A:P143A
36.9
-5
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
267
ARTICLE
Purification and molecular properties of rabbit lung indolamine N-methyltransferase.
1,982
10.1021/bi00535a054
7074100
Biochemistry;21;1464-70
4
Irace G|Colonna G|Camardella M|Della Pietra G
[{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"50 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2LZM_A:P143A","type":"_P...
[{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10888,"numValue":36.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv"],"id":10889,"numValue":-5.0,"references":[],"strValue":null,"type":"DTM"},{"...
[{"id":6934,"numValue":5.0,"position":143,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2862
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,862
train
mutant
1,600
41
1,800
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
P143A
P143A
1
1
0
0
143
P
A
5
CONSERVATION
1L63|2LZM
49|80
null
143
A
H
false
false
55.024902
16.895714
4,656
ProTherm
2
CD
Thermal
Phosphate buffer
50 mM
null
2LZM_A:P143A
36.9
-5
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|STATE|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
457
ARTICLE
Folding kinetics of T4 lysozyme and nine mutants at 12 degrees C.
1,992
10.1021/bi00120a025
1737005
Biochemistry;31;1464-76
4
Nicholson H|Baase W A|Schellman J A|Chen B L
[{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate buffer","type":"BUFFER"},{"numValue":null,"strValue":"50 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2LZM_A:P143A","ty...
[{"datasets":[],"id":17216,"numValue":36.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":17217,"numValue":-5.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":17218,"numValue":2.0,"references":[],"strValue":null,"type":"STATE"},{"datasets":[]...
[{"id":6934,"numValue":5.0,"position":143,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2863
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,863
train
mutant
1,600
41
1,800
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
P143A
P143A
1
1
0
0
143
P
A
5
CONSERVATION
1L63|2LZM
49|80
null
143
A
H
false
false
55.024902
16.895714
13,901
ProTherm
5.7
CD
GdnHCl
Phosphate buffer
50 mM
12
2LZM_A:P143A
null
null
17.2
null
null
null
null
3.01
null
null
null
null
null
null
null
null
yes
2.0
DG|CM|STATE|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
457
ARTICLE
Folding kinetics of T4 lysozyme and nine mutants at 12 degrees C.
1,992
10.1021/bi00120a025
1737005
Biochemistry;31;1464-76
4
Nicholson H|Baase W A|Schellman J A|Chen B L
[{"numValue":5.7,"strValue":null,"type":"PH"},{"numValue":12.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Phosphate buffer","type":"BUFFER"},{"numValue":null,"strValue":"50 mM","type":"BU...
[{"datasets":[],"id":51445,"numValue":17.2,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":51446,"numValue":3.01,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":51447,"numValue":2.0,"references":[],"strValue":null,"type":"STATE"},{"datasets":[],"id":51448,"numValue":null,"references":[...
[{"id":6934,"numValue":5.0,"position":143,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2864
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,864
train
mutant
507
41
557
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N144H
N144H
1
1
0
0
144
N
H
6
CONSERVATION
1L63|2LZM
49|80
null
144
A
H
false
false
101.804914
19.459375
822
ProTherm
2
CD
Thermal
HCl
0.01 N
null
KCl
200 mM
2LZM_A:N144H
37.2
-2.3
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
89
ARTICLE
Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme.
1,991
10.1021/bi00105a002
1911773
Biochemistry;30;9816-28
4
Nicholson H|Matthews B W|Dao-pin S|Anderson D E
[{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.01 N","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue...
[{"datasets":[],"id":3113,"numValue":37.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3114,"numValue":-2.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3115,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6935,"numValue":6.0,"position":144,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2865
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,865
train
mutant
507
41
557
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N144H
N144H
1
1
0
0
144
N
H
6
CONSERVATION
1L63|2LZM
49|80
null
144
A
H
false
false
101.804914
19.459375
827
ProTherm
6.7
CD
Thermal
HCl
0.01 N
null
KCl
200 mM
2LZM_A:N144H
63.1
0.7
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
89
ARTICLE
Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme.
1,991
10.1021/bi00105a002
1911773
Biochemistry;30;9816-28
4
Nicholson H|Matthews B W|Dao-pin S|Anderson D E
[{"numValue":6.7,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.01 N","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue...
[{"datasets":[],"id":3128,"numValue":63.1,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3129,"numValue":0.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3130,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6935,"numValue":6.0,"position":144,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2866
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,866
train
mutant
507
41
557
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N144H
N144H
1
1
0
0
144
N
H
6
CONSERVATION
1L63|2LZM
49|80
null
144
A
H
false
false
101.804914
19.459375
7,066
ProTherm
6.7
CD
Thermal
HCl
0.01 N
62.4
KCl
200 mM
2LZM_A:N144H
null
null
null
-0.3
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
89
ARTICLE
Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme.
1,991
10.1021/bi00105a002
1911773
Biochemistry;30;9816-28
4
Nicholson H|Matthews B W|Dao-pin S|Anderson D E
[{"numValue":6.7,"strValue":null,"type":"PH"},{"numValue":62.4,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.01 N","type":"BUFFER_CONC"}...
[{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":24806,"numValue":-0.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":24807,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6935,"numValue":6.0,"position":144,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2867
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,867
train
mutant
507
41
557
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N144H
N144H
1
1
0
0
144
N
H
6
CONSERVATION
1L63|2LZM
49|80
null
144
A
H
false
false
101.804914
19.459375
8,161
ProTherm
2
CD
Thermal
HCl
0.01 N
39.5
KCl
200 mM
2LZM_A:N144H
null
null
null
0.6
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
89
ARTICLE
Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme.
1,991
10.1021/bi00105a002
1911773
Biochemistry;30;9816-28
4
Nicholson H|Matthews B W|Dao-pin S|Anderson D E
[{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":39.5,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.01 N","type":"BUFFER_CONC"}...
[{"datasets":["capriotti_S1615_map.csv"],"id":27712,"numValue":0.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27713,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6935,"numValue":6.0,"position":144,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2868
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,868
train
mutant
528
41
579
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N144D
N144D
1
1
0
0
144
N
D
6
CONSERVATION
1L63|2LZM
49|80
null
144
A
H
false
false
101.804914
19.459375
901
ProTherm
3
CD
Thermal
KH2PO4,H3PO4,
17 mM,3 mM,
null
KCl
25 mM
2LZM_A:N144D
54.36
0.94
null
null
null
1.8
125
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DCP|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
97
ARTICLE
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive.
1,995
10.1093/protein/8.10.1017
8771182
Protein Eng;8;1017-22
5
Baase W A|Zhang X J|Matthews B W|Shoichet B K|Wilson K P
[{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"KH2PO4,H3PO4,","type":"BUFFER"},{"numValue":null,"strValue":"17 mM,3 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"I...
[{"datasets":[],"id":3336,"numValue":54.36,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":3337,"numValue":0.94,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":3338,"numValue":1.8,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id...
[{"id":6935,"numValue":6.0,"position":144,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2869
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,869
train
mutant
528
41
579
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N144D
N144D
1
1
0
0
144
N
D
6
CONSERVATION
1L63|2LZM
49|80
null
144
A
H
false
false
101.804914
19.459375
908
ProTherm
5.4
CD
Thermal
Acetic acid,Sodium acetate,
1.4 mM,8.6 mM,
null
NaCl
100 mM
2LZM_A:N144D
67.5
0.99
null
null
null
2.5
142
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DCP|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
97
ARTICLE
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive.
1,995
10.1093/protein/8.10.1017
8771182
Protein Eng;8;1017-22
5
Baase W A|Zhang X J|Matthews B W|Shoichet B K|Wilson K P
[{"numValue":5.4,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Acetic acid,Sodium acetate,","type":"BUFFER"},{"numValue":null,"strValue":"1.4 mM,8.6 mM,","type":"BUFFER_CONC"},{"numValue":null,"strValue...
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fireprotdb:2870
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,870
train
mutant
528
41
579
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N144D
N144D
1
1
0
0
144
N
D
6
CONSERVATION
1L63|2LZM
49|80
null
144
A
H
false
false
101.804914
19.459375
3,298
ProTherm
2
CD
Thermal
HCl
0.01 N
null
KCl
200 mM
2LZM_A:N144D
40.7
-0.2
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
89
ARTICLE
Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme.
1,991
10.1021/bi00105a002
1911773
Biochemistry;30;9816-28
4
Nicholson H|Matthews B W|Dao-pin S|Anderson D E
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fireprotdb:2871
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,871
train
mutant
528
41
579
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N144D
N144D
1
1
0
0
144
N
D
6
CONSERVATION
1L63|2LZM
49|80
null
144
A
H
false
false
101.804914
19.459375
3,303
ProTherm
6.9
CD
Thermal
phosphate
10 mM
null
KCl
150 mM
2LZM_A:N144D
67.5
1.4
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
89
ARTICLE
Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme.
1,991
10.1021/bi00105a002
1911773
Biochemistry;30;9816-28
4
Nicholson H|Matthews B W|Dao-pin S|Anderson D E
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fireprotdb:2872
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,872
train
mutant
528
41
579
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N144D
N144D
1
1
0
0
144
N
D
6
CONSERVATION
1L63|2LZM
49|80
null
144
A
H
false
false
101.804914
19.459375
6,723
ProTherm
5.4
CD
Thermal
Acetic acid, Sodium acetate
1.4 mM, 8.6 mM
66.51
NaCl
100 mM
2LZM_A:N144D
null
null
null
-0.41
null
2.5
null
null
null
null
null
null
null
null
null
null
Unknown
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
97
ARTICLE
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive.
1,995
10.1093/protein/8.10.1017
8771182
Protein Eng;8;1017-22
5
Baase W A|Zhang X J|Matthews B W|Shoichet B K|Wilson K P
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[{"id":6935,"numValue":6.0,"position":144,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2873
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,873
train
mutant
528
41
579
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N144D
N144D
1
1
0
0
144
N
D
6
CONSERVATION
1L63|2LZM
49|80
null
144
A
H
false
false
101.804914
19.459375
6,753
ProTherm
6.9
CD
Thermal
phosphate
10 mM
66.1
KCl
150 mM
2LZM_A:N144D
null
null
null
-0.5
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv|guerios_625_map.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
89
ARTICLE
Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme.
1,991
10.1021/bi00105a002
1911773
Biochemistry;30;9816-28
4
Nicholson H|Matthews B W|Dao-pin S|Anderson D E
[{"numValue":6.9,"strValue":null,"type":"PH"},{"numValue":66.1,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_C...
[{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","potapov_with_uniprot_mapping.csv"],"id":23976,"numValue":-0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":23977,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6935,"numValue":6.0,"position":144,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2875
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,875
train
mutant
528
41
579
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N144D
N144D
1
1
0
0
144
N
D
6
CONSERVATION
1L63|2LZM
49|80
null
144
A
H
false
false
101.804914
19.459375
8,067
ProTherm
2
CD
Thermal
HCl
0.01 N
40.9
KCl
200 mM
2LZM_A:N144D
null
null
null
0.1
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
89
ARTICLE
Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme.
1,991
10.1021/bi00105a002
1911773
Biochemistry;30;9816-28
4
Nicholson H|Matthews B W|Dao-pin S|Anderson D E
[{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":40.9,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.01 N","type":"BUFFER_CONC"}...
[{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":27449,"numValue":0.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27450,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":6935,"numValue":6.0,"position":144,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:2876
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
2,876
train
mutant
1,774
41
1,987
164
164
4
Endolysin
Enterobacteria phage T4
1
4
Endolysin
Enterobacteria phage T4
1
P00720
IPR034690|IPR002196|IPR023346|IPR023347|IPR052619|IPR001165
3.2.1.17
N144E
N144E
1
1
0
0
144
N
E
6
CONSERVATION
1L63|2LZM
49|80
null
144
A
H
false
false
101.804914
19.459375
3,410
ProTherm
2
CD
Thermal
HCl
10 mM
null
KCl
0.15 M
2LZM_A:N144E
39.4
0.9
null
null
null
null
83
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
302
ARTICLE
Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis.
1,991
10.1021/bi00243a015
1854726
Biochemistry;30;7142-53
4
Nicholson H|Matthews B W|Sauer U|Sun D P
[{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"KCl","type":"ION"},{"numValue"...
[{"datasets":[],"id":12579,"numValue":39.4,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":12580,"numValue":0.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":12581,"numValue":83.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],...
[{"id":6935,"numValue":6.0,"position":144,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]