row_id string | dataset_id string | source_dataset string | source_file string | source_table string | source_sha string | row_index int64 | split string | subject_type string | entry_id int64 | sequence_id int64 | target_sequence_id int64 | source_sequence_length int64 | target_sequence_length int64 | protein_id int64 | protein_name string | organism string | isoform int64 | protein_ids string | protein_names string | organisms string | isoforms string | uniprot_accessions string | interpro_accessions string | ec_numbers string | megascale_ids string | other_references string | mutations string | substitutions string | deletions string | insertions string | mutation_count int64 | substitution_count int64 | deletion_count int64 | insertion_count int64 | first_position int64 | first_source_aa string | first_target_aa string | conservation float64 | feature_types string | pdb_ids string | afdb_ids string | structure_ids string | structure_methods string | structure_resolution_min float64 | residue_positions string | residue_chain_names string | residue_secondary_structures string | residue_in_pocket_any bool | residue_in_tunnel_any bool | residue_asa_mean float64 | residue_bfactor_mean float64 | experiment_id int64 | experiment_dataset string | ph float64 | measure string | method string | buffer string | buffer_conc string | exp_temperature float64 | ion string | ion_conc string | pdb_chain_mutation string | tm float64 | dtm float64 | dg float64 | dg_text string | ddg float64 | dh float64 | dcp float64 | dhvh float64 | cm float64 | m_value float64 | trypsin_ml float64 | chymotrypsin_ml float64 | stabilizing float64 | stabilizing_text string | domainome_fitness float64 | domainome_fitness_std float64 | domainome_ddg float64 | domainome_ddg_std float64 | reversibility string | state string | measurement_types string | measurement_datasets string | annotation_types string | publication_id string | publication_type string | publication_title string | publication_year int64 | publication_doi string | publication_pmid string | publication_journal string | publication_url string | publication_author_count int64 | publication_authors string | annotations_json string | measurements_json string | features_json string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
fireprotdb:5461488 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,488 | train | mutant | 5,053,153 | 5,059,372 | 5,059,818 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1936I | K1936I | 1 | 1 | 0 | 0 | 1,936 | K | I | 7 | CONSERVATION | null | false | false | null | null | 5,439,656 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12871994,"numValue":null,"references":[],"strValue":"NA","type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12871995,"numValue":null,"references":[],"strValue":"NA","type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461559,"numValue":7.0,"position":1936,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461489 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,489 | train | mutant | 5,053,613 | 5,059,372 | 5,060,278 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1936L | K1936L | 1 | 1 | 0 | 0 | 1,936 | K | L | 7 | CONSERVATION | null | false | false | null | null | 5,440,117 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.14957 | 0.035299 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872916,"numValue":-0.149569636295427,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872917,"numValue":0.0352992823545486,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461559,"numValue":7.0,"position":1936,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461490 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,490 | train | mutant | 5,053,614 | 5,059,372 | 5,060,279 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1936M | K1936M | 1 | 1 | 0 | 0 | 1,936 | K | M | 7 | CONSERVATION | null | false | false | null | null | 5,440,118 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.124446 | 0.04095 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872918,"numValue":-0.124445952035588,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872919,"numValue":0.0409501334323402,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461559,"numValue":7.0,"position":1936,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461491 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,491 | train | mutant | 5,053,615 | 5,059,372 | 5,060,280 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1936N | K1936N | 1 | 1 | 0 | 0 | 1,936 | K | N | 7 | CONSERVATION | null | false | false | null | null | 5,440,119 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.316743 | 0.45033 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872920,"numValue":-0.316743330518217,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872921,"numValue":0.450330081079137,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461559,"numValue":7.0,"position":1936,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461492 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,492 | train | mutant | 5,053,616 | 5,059,372 | 5,060,281 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1936P | K1936P | 1 | 1 | 0 | 0 | 1,936 | K | P | 7 | CONSERVATION | null | false | false | null | null | 5,440,120 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.240004 | 0.054629 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872922,"numValue":-0.240003860296864,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872923,"numValue":0.054629432144846,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461559,"numValue":7.0,"position":1936,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461493 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,493 | train | mutant | 5,053,617 | 5,059,372 | 5,060,282 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1936Q | K1936Q | 1 | 1 | 0 | 0 | 1,936 | K | Q | 7 | CONSERVATION | null | false | false | null | null | 5,440,121 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.130159 | 0.046864 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872924,"numValue":-0.130159267344842,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872925,"numValue":0.0468643186228883,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461559,"numValue":7.0,"position":1936,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461494 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,494 | train | mutant | 5,053,618 | 5,059,372 | 5,060,283 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1936R | K1936R | 1 | 1 | 0 | 0 | 1,936 | K | R | 7 | CONSERVATION | null | false | false | null | null | 5,440,122 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.076213 | 0.023609 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872926,"numValue":-0.07621280199584,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872927,"numValue":0.0236094050180111,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461559,"numValue":7.0,"position":1936,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461495 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,495 | train | mutant | 5,053,619 | 5,059,372 | 5,060,284 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1936S | K1936S | 1 | 1 | 0 | 0 | 1,936 | K | S | 7 | CONSERVATION | null | false | false | null | null | 5,440,123 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.095156 | 0.037003 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872928,"numValue":-0.0951558391410791,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872929,"numValue":0.0370029505703268,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461559,"numValue":7.0,"position":1936,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461496 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,496 | train | mutant | 5,053,620 | 5,059,372 | 5,060,285 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1936T | K1936T | 1 | 1 | 0 | 0 | 1,936 | K | T | 7 | CONSERVATION | null | false | false | null | null | 5,440,124 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.08614 | 0.069931 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872930,"numValue":-0.0861403830536963,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872931,"numValue":0.0699308689919316,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461559,"numValue":7.0,"position":1936,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461497 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,497 | train | mutant | 5,053,621 | 5,059,372 | 5,060,286 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1936V | K1936V | 1 | 1 | 0 | 0 | 1,936 | K | V | 7 | CONSERVATION | null | false | false | null | null | 5,440,125 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.131274 | 0.054248 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872932,"numValue":-0.131274240077281,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872933,"numValue":0.0542475631834304,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461559,"numValue":7.0,"position":1936,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461498 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,498 | train | mutant | 5,053,622 | 5,059,372 | 5,060,287 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1936W | K1936W | 1 | 1 | 0 | 0 | 1,936 | K | W | 7 | CONSERVATION | null | false | false | null | null | 5,440,126 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.180091 | 0.035925 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872934,"numValue":-0.180090634929213,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872935,"numValue":0.0359253873809273,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461559,"numValue":7.0,"position":1936,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461499 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,499 | train | mutant | 5,053,623 | 5,059,372 | 5,060,288 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1936Y | K1936Y | 1 | 1 | 0 | 0 | 1,936 | K | Y | 7 | CONSERVATION | null | false | false | null | null | 5,440,127 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.201449 | 0.10552 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872936,"numValue":-0.201448986355822,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872937,"numValue":0.105520255844149,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461559,"numValue":7.0,"position":1936,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461500 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,500 | train | mutant | 5,053,154 | 5,059,372 | 5,059,819 | 2,610 | 2,609 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | delS1937 | delS1937 | 1 | 0 | 1 | 0 | 1,937 | S | - | 6 | CONSERVATION | null | false | false | null | null | 5,439,657 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.958524 | 0.112055 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12871996,"numValue":-0.958523898373913,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12871997,"numValue":0.112054713612954,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461501 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,501 | train | mutant | 5,053,155 | 5,059,372 | 5,059,820 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937A | S1937A | 1 | 1 | 0 | 0 | 1,937 | S | A | 6 | CONSERVATION | null | false | false | null | null | 5,439,658 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.096649 | 0.032272 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12871998,"numValue":-0.0966489090624896,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12871999,"numValue":0.0322721773832,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461502 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,502 | train | mutant | 5,053,156 | 5,059,372 | 5,059,821 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937C | S1937C | 1 | 1 | 0 | 0 | 1,937 | S | C | 6 | CONSERVATION | null | false | false | null | null | 5,439,659 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.141523 | 0.070113 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872000,"numValue":-0.141523341737438,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872001,"numValue":0.0701128800110018,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461503 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,503 | train | mutant | 5,053,157 | 5,059,372 | 5,059,822 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937D | S1937D | 1 | 1 | 0 | 0 | 1,937 | S | D | 6 | CONSERVATION | null | false | false | null | null | 5,439,660 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.057737 | 0.051225 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872002,"numValue":-0.0577366366836974,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872003,"numValue":0.0512254075134849,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461504 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,504 | train | mutant | 5,053,158 | 5,059,372 | 5,059,823 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937E | S1937E | 1 | 1 | 0 | 0 | 1,937 | S | E | 6 | CONSERVATION | null | false | false | null | null | 5,439,661 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.064853 | 0.034614 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872004,"numValue":-0.0648528673534882,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872005,"numValue":0.0346137627127204,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461505 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,505 | train | mutant | 5,053,159 | 5,059,372 | 5,059,824 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937F | S1937F | 1 | 1 | 0 | 0 | 1,937 | S | F | 6 | CONSERVATION | null | false | false | null | null | 5,439,662 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.15544 | 0.042345 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872006,"numValue":-0.155440262113961,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872007,"numValue":0.0423450820735179,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461506 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,506 | train | mutant | 5,053,160 | 5,059,372 | 5,059,825 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937G | S1937G | 1 | 1 | 0 | 0 | 1,937 | S | G | 6 | CONSERVATION | null | false | false | null | null | 5,439,663 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.127759 | 0.029933 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872008,"numValue":-0.127758672175451,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872009,"numValue":0.0299333288885632,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461507 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,507 | train | mutant | 5,053,161 | 5,059,372 | 5,059,826 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937H | S1937H | 1 | 1 | 0 | 0 | 1,937 | S | H | 6 | CONSERVATION | null | false | false | null | null | 5,439,664 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.135359 | 0.130543 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872010,"numValue":-0.135358793651565,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872011,"numValue":0.13054274620913,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461508 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,508 | train | mutant | 5,053,162 | 5,059,372 | 5,059,827 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937I | S1937I | 1 | 1 | 0 | 0 | 1,937 | S | I | 6 | CONSERVATION | null | false | false | null | null | 5,439,665 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.177645 | 0.127418 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872012,"numValue":-0.177644502507136,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872013,"numValue":0.127417556755329,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461509 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,509 | train | mutant | 5,053,163 | 5,059,372 | 5,059,828 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937K | S1937K | 1 | 1 | 0 | 0 | 1,937 | S | K | 6 | CONSERVATION | null | false | false | null | null | 5,439,666 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | 0.009815 | 0.069905 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872014,"numValue":0.00981534782901337,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872015,"numValue":0.0699050185515177,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461510 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,510 | train | mutant | 5,053,164 | 5,059,372 | 5,059,829 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937L | S1937L | 1 | 1 | 0 | 0 | 1,937 | S | L | 6 | CONSERVATION | null | false | false | null | null | 5,439,667 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.13152 | 0.02597 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872016,"numValue":-0.131519865258438,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872017,"numValue":0.0259703643786744,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461511 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,511 | train | mutant | 5,053,165 | 5,059,372 | 5,059,830 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937M | S1937M | 1 | 1 | 0 | 0 | 1,937 | S | M | 6 | CONSERVATION | null | false | false | null | null | 5,439,668 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.121212 | 0.063072 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872018,"numValue":-0.121212347122613,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872019,"numValue":0.0630715328234062,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461512 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,512 | train | mutant | 5,053,166 | 5,059,372 | 5,059,831 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937N | S1937N | 1 | 1 | 0 | 0 | 1,937 | S | N | 6 | CONSERVATION | null | false | false | null | null | 5,439,669 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | 0.003148 | 0.055978 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872020,"numValue":0.00314759010234493,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872021,"numValue":0.0559782547688583,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461515 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,515 | train | mutant | 5,053,169 | 5,059,372 | 5,059,834 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937R | S1937R | 1 | 1 | 0 | 0 | 1,937 | S | R | 6 | CONSERVATION | null | false | false | null | null | 5,439,672 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.004032 | 0.029583 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872026,"numValue":-0.00403211673785707,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872027,"numValue":0.0295831934126307,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461516 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,516 | train | mutant | 5,053,609 | 5,059,372 | 5,060,274 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937T | S1937T | 1 | 1 | 0 | 0 | 1,937 | S | T | 6 | CONSERVATION | null | false | false | null | null | 5,440,113 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.067543 | 0.039358 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872908,"numValue":-0.0675427850677237,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872909,"numValue":0.0393576543083989,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461517 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,517 | train | mutant | 5,053,610 | 5,059,372 | 5,060,275 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937V | S1937V | 1 | 1 | 0 | 0 | 1,937 | S | V | 6 | CONSERVATION | null | false | false | null | null | 5,440,114 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.126921 | 0.044742 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872910,"numValue":-0.126921062709374,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872911,"numValue":0.0447423424441005,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461518 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,518 | train | mutant | 5,053,611 | 5,059,372 | 5,060,276 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937W | S1937W | 1 | 1 | 0 | 0 | 1,937 | S | W | 6 | CONSERVATION | null | false | false | null | null | 5,440,115 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.137918 | 0.02584 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872912,"numValue":-0.137917619274734,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872913,"numValue":0.0258403302237814,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461519 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,519 | train | mutant | 5,053,612 | 5,059,372 | 5,060,277 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | S1937Y | S1937Y | 1 | 1 | 0 | 0 | 1,937 | S | Y | 6 | CONSERVATION | null | false | false | null | null | 5,440,116 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.06521 | 0.045273 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872914,"numValue":-0.065210265791238,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872915,"numValue":0.0452726904476083,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461560,"numValue":6.0,"position":1937,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461520 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,520 | train | mutant | 5,053,170 | 5,059,372 | 5,059,835 | 2,610 | 2,609 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | delI1938 | delI1938 | 1 | 0 | 1 | 0 | 1,938 | I | - | 7 | CONSERVATION | null | false | false | null | null | 5,439,673 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.717557 | 0.139821 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872028,"numValue":-0.717557168968027,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872029,"numValue":0.139821306423145,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461521 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,521 | train | mutant | 5,053,171 | 5,059,372 | 5,059,836 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938A | I1938A | 1 | 1 | 0 | 0 | 1,938 | I | A | 7 | CONSERVATION | null | false | false | null | null | 5,439,674 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.115451 | 0.047097 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872030,"numValue":-0.115451194699426,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872031,"numValue":0.047097478556087,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461522 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,522 | train | mutant | 5,053,172 | 5,059,372 | 5,059,837 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938C | I1938C | 1 | 1 | 0 | 0 | 1,938 | I | C | 7 | CONSERVATION | null | false | false | null | null | 5,439,675 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.116333 | 0.064934 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872032,"numValue":-0.116332961501442,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872033,"numValue":0.0649338224693749,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461523 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,523 | train | mutant | 5,053,173 | 5,059,372 | 5,059,838 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938D | I1938D | 1 | 1 | 0 | 0 | 1,938 | I | D | 7 | CONSERVATION | null | false | false | null | null | 5,439,676 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.170101 | 0.053132 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872034,"numValue":-0.170101417589943,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872035,"numValue":0.0531319004926168,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461524 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,524 | train | mutant | 5,053,174 | 5,059,372 | 5,059,839 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938E | I1938E | 1 | 1 | 0 | 0 | 1,938 | I | E | 7 | CONSERVATION | null | false | false | null | null | 5,439,677 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.103204 | 0.043578 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872036,"numValue":-0.103203513615816,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872037,"numValue":0.0435780238887499,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461525 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,525 | train | mutant | 5,053,175 | 5,059,372 | 5,059,840 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938F | I1938F | 1 | 1 | 0 | 0 | 1,938 | I | F | 7 | CONSERVATION | null | false | false | null | null | 5,439,678 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.464451 | 0.127408 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872038,"numValue":-0.464450539176,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872039,"numValue":0.127408081326992,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461526 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,526 | train | mutant | 5,053,176 | 5,059,372 | 5,059,841 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938G | I1938G | 1 | 1 | 0 | 0 | 1,938 | I | G | 7 | CONSERVATION | null | false | false | null | null | 5,439,679 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.167825 | 0.031513 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872040,"numValue":-0.167825474900128,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872041,"numValue":0.031513324365657,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461527 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,527 | train | mutant | 5,053,177 | 5,059,372 | 5,059,842 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938H | I1938H | 1 | 1 | 0 | 0 | 1,938 | I | H | 7 | CONSERVATION | null | false | false | null | null | 5,439,680 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.180622 | 0.066756 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872042,"numValue":-0.180622362849469,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872043,"numValue":0.0667560485324247,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461528 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,528 | train | mutant | 5,053,597 | 5,059,372 | 5,060,262 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938K | I1938K | 1 | 1 | 0 | 0 | 1,938 | I | K | 7 | CONSERVATION | null | false | false | null | null | 5,440,101 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.194098 | 0.047153 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872884,"numValue":-0.19409770986661,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872885,"numValue":0.0471534571788336,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461529 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,529 | train | mutant | 5,053,598 | 5,059,372 | 5,060,263 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938L | I1938L | 1 | 1 | 0 | 0 | 1,938 | I | L | 7 | CONSERVATION | null | false | false | null | null | 5,440,102 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.102366 | 0.042438 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872886,"numValue":-0.102365904149739,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872887,"numValue":0.0424381068612278,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461530 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,530 | train | mutant | 5,053,599 | 5,059,372 | 5,060,264 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938M | I1938M | 1 | 1 | 0 | 0 | 1,938 | I | M | 7 | CONSERVATION | null | false | false | null | null | 5,440,103 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.019574 | 0.062314 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872888,"numValue":-0.0195741190713559,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872889,"numValue":0.0623143265065159,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461531 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,531 | train | mutant | 5,053,600 | 5,059,372 | 5,060,265 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938N | I1938N | 1 | 1 | 0 | 0 | 1,938 | I | N | 7 | CONSERVATION | null | false | false | null | null | 5,440,104 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.218258 | 0.056766 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872890,"numValue":-0.218258212236297,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872891,"numValue":0.056765911248656,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461532 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,532 | train | mutant | 5,053,601 | 5,059,372 | 5,060,266 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938P | I1938P | 1 | 1 | 0 | 0 | 1,938 | I | P | 7 | CONSERVATION | null | false | false | null | null | 5,440,105 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.19716 | 0.099497 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872892,"numValue":-0.197159745130574,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872893,"numValue":0.099496781247154,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461533 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,533 | train | mutant | 5,053,602 | 5,059,372 | 5,060,267 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938Q | I1938Q | 1 | 1 | 0 | 0 | 1,938 | I | Q | 7 | CONSERVATION | null | false | false | null | null | 5,440,106 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.188049 | 0.063909 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872894,"numValue":-0.188049074787575,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872895,"numValue":0.0639085443255598,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461534 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,534 | train | mutant | 5,053,603 | 5,059,372 | 5,060,268 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938R | I1938R | 1 | 1 | 0 | 0 | 1,938 | I | R | 7 | CONSERVATION | null | false | false | null | null | 5,440,107 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.249541 | 0.033364 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872896,"numValue":-0.249541384887266,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872897,"numValue":0.0333636639325875,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461535 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,535 | train | mutant | 5,053,604 | 5,059,372 | 5,060,269 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938S | I1938S | 1 | 1 | 0 | 0 | 1,938 | I | S | 7 | CONSERVATION | null | false | false | null | null | 5,440,108 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.175278 | 0.032312 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872898,"numValue":-0.175278405256447,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872899,"numValue":0.0323120569772192,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461536 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,536 | train | mutant | 5,053,605 | 5,059,372 | 5,060,270 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938T | I1938T | 1 | 1 | 0 | 0 | 1,938 | I | T | 7 | CONSERVATION | null | false | false | null | null | 5,440,109 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.085616 | 0.047439 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872900,"numValue":-0.0856164746616795,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872901,"numValue":0.0474390999456838,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461537 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,537 | train | mutant | 5,053,606 | 5,059,372 | 5,060,271 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938V | I1938V | 1 | 1 | 0 | 0 | 1,938 | I | V | 7 | CONSERVATION | null | false | false | null | null | 5,440,110 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.024196 | 0.025319 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872902,"numValue":-0.0241959202328877,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872903,"numValue":0.0253194576486103,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461538 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,538 | train | mutant | 5,053,607 | 5,059,372 | 5,060,272 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938W | I1938W | 1 | 1 | 0 | 0 | 1,938 | I | W | 7 | CONSERVATION | null | false | false | null | null | 5,440,111 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.314566 | 0.054699 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872904,"numValue":-0.314566281862014,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872905,"numValue":0.0546990719433985,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461539 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,539 | train | mutant | 5,053,608 | 5,059,372 | 5,060,273 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | I1938Y | I1938Y | 1 | 1 | 0 | 0 | 1,938 | I | Y | 7 | CONSERVATION | null | false | false | null | null | 5,440,112 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.336283 | 0.122846 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872906,"numValue":-0.336282951670871,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872907,"numValue":0.122846214549551,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461561,"numValue":7.0,"position":1938,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461540 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,540 | train | mutant | 5,053,178 | 5,059,372 | 5,059,843 | 2,610 | 2,609 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | delR1939 | delR1939 | 1 | 0 | 1 | 0 | 1,939 | R | - | 8 | CONSERVATION | null | false | false | null | null | 5,439,681 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -1.086644 | 0.138433 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872044,"numValue":-1.08664432952404,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872045,"numValue":0.138433478152387,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461541 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,541 | train | mutant | 5,053,179 | 5,059,372 | 5,059,844 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939A | R1939A | 1 | 1 | 0 | 0 | 1,939 | R | A | 8 | CONSERVATION | null | false | false | null | null | 5,439,682 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.081632 | 0.028545 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872046,"numValue":-0.0816321950377555,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872047,"numValue":0.0285451648380635,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461542 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,542 | train | mutant | 5,053,180 | 5,059,372 | 5,059,845 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939C | R1939C | 1 | 1 | 0 | 0 | 1,939 | R | C | 8 | CONSERVATION | null | false | false | null | null | 5,439,683 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.095121 | 0.032791 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872048,"numValue":-0.0951213412223774,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872049,"numValue":0.0327909018879665,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461543 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,543 | train | mutant | 5,053,181 | 5,059,372 | 5,059,846 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939D | R1939D | 1 | 1 | 0 | 0 | 1,939 | R | D | 8 | CONSERVATION | null | false | false | null | null | 5,439,684 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.174525 | 0.040089 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872050,"numValue":-0.174524510739752,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872051,"numValue":0.0400891527762726,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461544 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,544 | train | mutant | 5,053,182 | 5,059,372 | 5,059,847 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939E | R1939E | 1 | 1 | 0 | 0 | 1,939 | R | E | 8 | CONSERVATION | null | false | false | null | null | 5,439,685 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.112331 | 0.028203 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872052,"numValue":-0.112330742959793,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872053,"numValue":0.0282025591078529,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461545 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,545 | train | mutant | 5,053,183 | 5,059,372 | 5,059,848 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939F | R1939F | 1 | 1 | 0 | 0 | 1,939 | R | F | 8 | CONSERVATION | null | false | false | null | null | 5,439,686 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.164307 | 0.050438 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872054,"numValue":-0.164306687192552,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872055,"numValue":0.0504375670447875,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461546 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,546 | train | mutant | 5,053,184 | 5,059,372 | 5,059,849 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939G | R1939G | 1 | 1 | 0 | 0 | 1,939 | R | G | 8 | CONSERVATION | null | false | false | null | null | 5,439,687 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.121528 | 0.024784 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872056,"numValue":-0.121528348057921,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872057,"numValue":0.0247839303575748,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461547 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,547 | train | mutant | 5,053,185 | 5,059,372 | 5,059,850 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939H | R1939H | 1 | 1 | 0 | 0 | 1,939 | R | H | 8 | CONSERVATION | null | false | false | null | null | 5,439,688 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.085102 | 0.065112 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872058,"numValue":-0.0851017657146499,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872059,"numValue":0.0651123376993501,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461548 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,548 | train | mutant | 5,053,186 | 5,059,372 | 5,059,851 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939I | R1939I | 1 | 1 | 0 | 0 | 1,939 | R | I | 8 | CONSERVATION | null | false | false | null | null | 5,439,689 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.107443 | 0.081895 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872060,"numValue":-0.107442617865884,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872061,"numValue":0.0818954371560621,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461550 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,550 | train | mutant | 5,053,188 | 5,059,372 | 5,059,853 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939L | R1939L | 1 | 1 | 0 | 0 | 1,939 | R | L | 8 | CONSERVATION | null | false | false | null | null | 5,439,691 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.112045 | 0.028722 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872064,"numValue":-0.112044640220693,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872065,"numValue":0.0287217389851464,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461552 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,552 | train | mutant | 5,053,190 | 5,059,372 | 5,059,855 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939N | R1939N | 1 | 1 | 0 | 0 | 1,939 | R | N | 8 | CONSERVATION | null | false | false | null | null | 5,439,693 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872068,"numValue":null,"references":[],"strValue":"NA","type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872069,"numValue":null,"references":[],"strValue":"NA","type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461553 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,553 | train | mutant | 5,053,191 | 5,059,372 | 5,059,856 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939P | R1939P | 1 | 1 | 0 | 0 | 1,939 | R | P | 8 | CONSERVATION | null | false | false | null | null | 5,439,694 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.177017 | 0.042709 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872070,"numValue":-0.177016640386765,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872071,"numValue":0.0427093340977832,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461554 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,554 | train | mutant | 5,053,192 | 5,059,372 | 5,059,857 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939Q | R1939Q | 1 | 1 | 0 | 0 | 1,939 | R | Q | 8 | CONSERVATION | null | false | false | null | null | 5,439,695 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.062137 | 0.029245 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872072,"numValue":-0.0621367312210394,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872073,"numValue":0.029244649237382,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461555 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,555 | train | mutant | 5,053,592 | 5,059,372 | 5,060,257 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939S | R1939S | 1 | 1 | 0 | 0 | 1,939 | R | S | 8 | CONSERVATION | null | false | false | null | null | 5,440,096 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.11279 | 0.02566 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872874,"numValue":-0.1127902552369,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872875,"numValue":0.0256599843042538,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461556 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,556 | train | mutant | 5,053,593 | 5,059,372 | 5,060,258 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939T | R1939T | 1 | 1 | 0 | 0 | 1,939 | R | T | 8 | CONSERVATION | null | false | false | null | null | 5,440,097 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.113502 | 0.033233 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872876,"numValue":-0.113501832306654,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872877,"numValue":0.033232898421818,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461557 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,557 | train | mutant | 5,053,594 | 5,059,372 | 5,060,259 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939V | R1939V | 1 | 1 | 0 | 0 | 1,939 | R | V | 8 | CONSERVATION | null | false | false | null | null | 5,440,098 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.108605 | 0.035004 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872878,"numValue":-0.108605427712256,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872879,"numValue":0.0350035201982125,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461558 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,558 | train | mutant | 5,053,595 | 5,059,372 | 5,060,260 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939W | R1939W | 1 | 1 | 0 | 0 | 1,939 | R | W | 8 | CONSERVATION | null | false | false | null | null | 5,440,099 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.142734 | 0.030338 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872880,"numValue":-0.142733988697743,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872881,"numValue":0.0303380630704943,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461559 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,559 | train | mutant | 5,053,596 | 5,059,372 | 5,060,261 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | R1939Y | R1939Y | 1 | 1 | 0 | 0 | 1,939 | R | Y | 8 | CONSERVATION | null | false | false | null | null | 5,440,100 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.143554 | 0.047029 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872882,"numValue":-0.143554119218346,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872883,"numValue":0.0470288046992581,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461562,"numValue":8.0,"position":1939,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461560 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,560 | train | mutant | 5,053,193 | 5,059,372 | 5,059,858 | 2,610 | 2,609 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | delK1940 | delK1940 | 1 | 0 | 1 | 0 | 1,940 | K | - | 8 | CONSERVATION | null | false | false | null | null | 5,439,696 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -1.13589 | 0.462412 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872074,"numValue":-1.13588960250127,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872075,"numValue":0.462411942166853,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461561 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,561 | train | mutant | 5,053,194 | 5,059,372 | 5,059,859 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940A | K1940A | 1 | 1 | 0 | 0 | 1,940 | K | A | 8 | CONSERVATION | null | false | false | null | null | 5,439,697 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.142413 | 0.035366 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872076,"numValue":-0.142412928067693,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872077,"numValue":0.0353659691312602,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461562 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,562 | train | mutant | 5,053,195 | 5,059,372 | 5,059,860 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940C | K1940C | 1 | 1 | 0 | 0 | 1,940 | K | C | 8 | CONSERVATION | null | false | false | null | null | 5,439,698 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.202342 | 0.047791 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872078,"numValue":-0.202341792491822,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872079,"numValue":0.0477913006970159,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461563 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,563 | train | mutant | 5,053,196 | 5,059,372 | 5,059,861 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940D | K1940D | 1 | 1 | 0 | 0 | 1,940 | K | D | 8 | CONSERVATION | null | false | false | null | null | 5,439,699 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.097318 | 0.041096 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872080,"numValue":-0.0973177087130535,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872081,"numValue":0.0410957100495389,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461566 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,566 | train | mutant | 5,053,199 | 5,059,372 | 5,059,864 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940G | K1940G | 1 | 1 | 0 | 0 | 1,940 | K | G | 8 | CONSERVATION | null | false | false | null | null | 5,439,702 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.178678 | 0.026971 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872086,"numValue":-0.17867806015144,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872087,"numValue":0.0269706062329571,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461567 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,567 | train | mutant | 5,053,200 | 5,059,372 | 5,059,865 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940H | K1940H | 1 | 1 | 0 | 0 | 1,940 | K | H | 8 | CONSERVATION | null | false | false | null | null | 5,439,703 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | 0.059874 | 0.162765 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872088,"numValue":0.059874127726456,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872089,"numValue":0.162765090198835,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461568 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,568 | train | mutant | 5,053,201 | 5,059,372 | 5,059,866 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940I | K1940I | 1 | 1 | 0 | 0 | 1,940 | K | I | 8 | CONSERVATION | null | false | false | null | null | 5,439,704 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.430252 | 0.314525 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872090,"numValue":-0.430251602436362,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872091,"numValue":0.314525114345696,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461569 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,569 | train | mutant | 5,053,581 | 5,059,372 | 5,060,246 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940L | K1940L | 1 | 1 | 0 | 0 | 1,940 | K | L | 8 | CONSERVATION | null | false | false | null | null | 5,440,085 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.174536 | 0.053316 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872852,"numValue":-0.174535550073737,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872853,"numValue":0.0533162113729338,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461570 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,570 | train | mutant | 5,053,582 | 5,059,372 | 5,060,247 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940M | K1940M | 1 | 1 | 0 | 0 | 1,940 | K | M | 8 | CONSERVATION | null | false | false | null | null | 5,440,086 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.232718 | 0.07434 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872854,"numValue":-0.23271835983931,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872855,"numValue":0.0743404849548353,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461571 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,571 | train | mutant | 5,053,583 | 5,059,372 | 5,060,248 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940N | K1940N | 1 | 1 | 0 | 0 | 1,940 | K | N | 8 | CONSERVATION | null | false | false | null | null | 5,440,087 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.087547 | 0.086159 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872856,"numValue":-0.0875465182199784,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872857,"numValue":0.0861592419159199,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461572 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,572 | train | mutant | 5,053,584 | 5,059,372 | 5,060,249 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940P | K1940P | 1 | 1 | 0 | 0 | 1,940 | K | P | 8 | CONSERVATION | null | false | false | null | null | 5,440,088 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.30021 | 0.100805 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872858,"numValue":-0.300209628015106,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872859,"numValue":0.100804666340974,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461573 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,573 | train | mutant | 5,053,585 | 5,059,372 | 5,060,250 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940Q | K1940Q | 1 | 1 | 0 | 0 | 1,940 | K | Q | 8 | CONSERVATION | null | false | false | null | null | 5,440,089 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.174717 | 0.073953 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872860,"numValue":-0.174716779139983,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872861,"numValue":0.0739533723097771,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461574 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,574 | train | mutant | 5,053,586 | 5,059,372 | 5,060,251 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940R | K1940R | 1 | 1 | 0 | 0 | 1,940 | K | R | 8 | CONSERVATION | null | false | false | null | null | 5,440,090 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.056795 | 0.066308 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872862,"numValue":-0.0567946135170157,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872863,"numValue":0.066307851572652,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461575 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,575 | train | mutant | 5,053,587 | 5,059,372 | 5,060,252 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940S | K1940S | 1 | 1 | 0 | 0 | 1,940 | K | S | 8 | CONSERVATION | null | false | false | null | null | 5,440,091 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.154771 | 0.054123 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872864,"numValue":-0.154770542518898,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872865,"numValue":0.0541225887232803,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461576 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,576 | train | mutant | 5,053,588 | 5,059,372 | 5,060,253 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940T | K1940T | 1 | 1 | 0 | 0 | 1,940 | K | T | 8 | CONSERVATION | null | false | false | null | null | 5,440,092 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.149358 | 0.193993 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872866,"numValue":-0.149357589088474,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872867,"numValue":0.193993158174331,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461577 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,577 | train | mutant | 5,053,589 | 5,059,372 | 5,060,254 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940V | K1940V | 1 | 1 | 0 | 0 | 1,940 | K | V | 8 | CONSERVATION | null | false | false | null | null | 5,440,093 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.179131 | 0.037547 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872868,"numValue":-0.179130672844806,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872869,"numValue":0.0375465089768361,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461578 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,578 | train | mutant | 5,053,590 | 5,059,372 | 5,060,255 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940W | K1940W | 1 | 1 | 0 | 0 | 1,940 | K | W | 8 | CONSERVATION | null | false | false | null | null | 5,440,094 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.384796 | 0.069145 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872870,"numValue":-0.384796224810477,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872871,"numValue":0.0691453283844809,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461579 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,579 | train | mutant | 5,053,591 | 5,059,372 | 5,060,256 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | K1940Y | K1940Y | 1 | 1 | 0 | 0 | 1,940 | K | Y | 8 | CONSERVATION | null | false | false | null | null | 5,440,095 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872872,"numValue":null,"references":[],"strValue":"NA","type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872873,"numValue":null,"references":[],"strValue":"NA","type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461563,"numValue":8.0,"position":1940,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461580 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,580 | train | mutant | 5,053,202 | 5,059,372 | 5,059,867 | 2,610 | 2,609 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | delN1941 | delN1941 | 1 | 0 | 1 | 0 | 1,941 | N | - | 5 | CONSERVATION | null | false | false | null | null | 5,439,705 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.867749 | 0.171909 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872092,"numValue":-0.867749147716833,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872093,"numValue":0.171909108529913,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461581 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,581 | train | mutant | 5,053,203 | 5,059,372 | 5,059,868 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941A | N1941A | 1 | 1 | 0 | 0 | 1,941 | N | A | 5 | CONSERVATION | null | false | false | null | null | 5,439,706 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.06245 | 0.039136 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872094,"numValue":-0.0624499723228511,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872095,"numValue":0.0391358924875392,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461582 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,582 | train | mutant | 5,053,204 | 5,059,372 | 5,059,869 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941C | N1941C | 1 | 1 | 0 | 0 | 1,941 | N | C | 5 | CONSERVATION | null | false | false | null | null | 5,439,707 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.230608 | 0.095957 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872096,"numValue":-0.230607547187014,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872097,"numValue":0.0959566508272084,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461583 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,583 | train | mutant | 5,053,205 | 5,059,372 | 5,059,870 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941D | N1941D | 1 | 1 | 0 | 0 | 1,941 | N | D | 5 | CONSERVATION | null | false | false | null | null | 5,439,708 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.125276 | 0.056489 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872098,"numValue":-0.125275741973426,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872099,"numValue":0.0564887779684188,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461584 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,584 | train | mutant | 5,053,206 | 5,059,372 | 5,059,871 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941E | N1941E | 1 | 1 | 0 | 0 | 1,941 | N | E | 5 | CONSERVATION | null | false | false | null | null | 5,439,709 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.135066 | 0.035974 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872100,"numValue":-0.135065791328725,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872101,"numValue":0.0359740432454642,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461585 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,585 | train | mutant | 5,053,207 | 5,059,372 | 5,059,872 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941F | N1941F | 1 | 1 | 0 | 0 | 1,941 | N | F | 5 | CONSERVATION | null | false | false | null | null | 5,439,710 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.18146 | 0.039758 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872102,"numValue":-0.181460432287796,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872103,"numValue":0.0397579819561811,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461586 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,586 | train | mutant | 5,053,208 | 5,059,372 | 5,059,873 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941G | N1941G | 1 | 1 | 0 | 0 | 1,941 | N | G | 5 | CONSERVATION | null | false | false | null | null | 5,439,711 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.100161 | 0.028915 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872104,"numValue":-0.100161257158574,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872105,"numValue":0.0289151251179432,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461587 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,587 | train | mutant | 5,053,209 | 5,059,372 | 5,059,874 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941H | N1941H | 1 | 1 | 0 | 0 | 1,941 | N | H | 5 | CONSERVATION | null | false | false | null | null | 5,439,712 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | 0.012288 | 0.050748 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872106,"numValue":0.0122881586415527,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872107,"numValue":0.0507475423436287,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461588 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,588 | train | mutant | 5,053,210 | 5,059,372 | 5,059,875 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941I | N1941I | 1 | 1 | 0 | 0 | 1,941 | N | I | 5 | CONSERVATION | null | false | false | null | null | 5,439,713 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.31189 | 0.070726 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872108,"numValue":-0.311889703343009,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872109,"numValue":0.0707263909971932,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461589 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,589 | train | mutant | 5,053,211 | 5,059,372 | 5,059,876 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941K | N1941K | 1 | 1 | 0 | 0 | 1,941 | N | K | 5 | CONSERVATION | null | false | false | null | null | 5,439,714 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | 0.046333 | 0.038213 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872110,"numValue":0.0463330046776568,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872111,"numValue":0.0382131513575506,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461590 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,590 | train | mutant | 5,053,212 | 5,059,372 | 5,059,877 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941L | N1941L | 1 | 1 | 0 | 0 | 1,941 | N | L | 5 | CONSERVATION | null | false | false | null | null | 5,439,715 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.161114 | 0.021562 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872112,"numValue":-0.16111401980977,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872113,"numValue":0.0215621191330738,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461591 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,591 | train | mutant | 5,053,213 | 5,059,372 | 5,059,878 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941M | N1941M | 1 | 1 | 0 | 0 | 1,941 | N | M | 5 | CONSERVATION | null | false | false | null | null | 5,439,716 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.228562 | 0.04234 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872114,"numValue":-0.228562050594127,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872115,"numValue":0.0423404823510244,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461592 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,592 | train | mutant | 5,053,573 | 5,059,372 | 5,060,238 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941P | N1941P | 1 | 1 | 0 | 0 | 1,941 | N | P | 5 | CONSERVATION | null | false | false | null | null | 5,440,077 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.263062 | 0.048475 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872836,"numValue":-0.263062269157094,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872837,"numValue":0.0484751874373588,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||||||||||||||
fireprotdb:5461593 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 5,461,593 | train | mutant | 5,053,574 | 5,059,372 | 5,060,239 | 2,610 | 2,610 | 8,257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | 8257 | E3 ubiquitin-protein ligase HECTD1 | Homo sapiens | 1 | Q9ULT8 | IPR002110|IPR036770|IPR011989|IPR016024|IPR041200|IPR008979|IPR000569|IPR035983|IPR045322|IPR010606|IPR037252|IPR012919 | 2.3.2.26 | N1941Q | N1941Q | 1 | 1 | 0 | 0 | 1,941 | N | Q | 5 | CONSERVATION | null | false | false | null | null | 5,440,078 | Domainome FITNESS | null | null | null | null | null | null | null | null | null | null | null | null | null | null | -0.054258 | 0.02122 | null | null | DOMAINOME_FITNESS|DOMAINOME_FITNESS_STD | 1910 | ARTICLE | Site-saturation mutagenesis of 500 human protein domains. | 2,025 | 10.1038/s41586-024-08370-4 | 39779847 | Nature;637;885-894 | 1 | Beltran Antoni | [{"datasets":[],"id":12872838,"numValue":-0.054257866561816,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS"},{"datasets":[],"id":12872839,"numValue":0.0212200193723375,"references":[],"strValue":null,"type":"DOMAINOME_FITNESS_STD"}] | [{"id":1461564,"numValue":5.0,"position":1941,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] |
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