row_id string | dataset_id string | source_dataset string | source_file string | source_table string | source_sha string | row_index int64 | split string | subject_type string | entry_id int64 | sequence_id int64 | target_sequence_id int64 | source_sequence_length int64 | target_sequence_length int64 | protein_id int64 | protein_name string | organism string | isoform int64 | protein_ids string | protein_names string | organisms string | isoforms string | uniprot_accessions string | interpro_accessions string | ec_numbers string | megascale_ids string | other_references string | mutations string | substitutions string | deletions string | insertions string | mutation_count int64 | substitution_count int64 | deletion_count int64 | insertion_count int64 | first_position int64 | first_source_aa string | first_target_aa string | conservation float64 | feature_types string | pdb_ids string | afdb_ids string | structure_ids string | structure_methods string | structure_resolution_min float64 | residue_positions string | residue_chain_names string | residue_secondary_structures string | residue_in_pocket_any bool | residue_in_tunnel_any bool | residue_asa_mean float64 | residue_bfactor_mean float64 | experiment_id int64 | experiment_dataset string | ph float64 | measure string | method string | buffer string | buffer_conc string | exp_temperature float64 | ion string | ion_conc string | pdb_chain_mutation string | tm float64 | dtm float64 | dg float64 | dg_text string | ddg float64 | dh float64 | dcp float64 | dhvh float64 | cm float64 | m_value float64 | trypsin_ml float64 | chymotrypsin_ml float64 | stabilizing float64 | stabilizing_text string | domainome_fitness float64 | domainome_fitness_std float64 | domainome_ddg float64 | domainome_ddg_std float64 | reversibility string | state string | measurement_types string | measurement_datasets string | annotation_types string | publication_id string | publication_type string | publication_title string | publication_year int64 | publication_doi string | publication_pmid string | publication_journal string | publication_url string | publication_author_count int64 | publication_authors string | annotations_json string | measurements_json string | features_json string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
fireprotdb:7010 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,010 | train | mutant | 1,594 | 117 | 1,794 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148W | V148W | 1 | 1 | 0 | 0 | 148 | V | W | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 3,037 | ProTherm | 7 | DSC | Thermal | Sodium phosphate | 20 mM | null | NaCl | 100 mM | 1STN_A:V66W | 46.3 | -7.8 | null | null | 67 | null | null | null | null | null | null | null | null | null | null | null | yes | 3.0 | TM|DTM|DH|STATE|REVERSIBILITY | AUTOMUTE_S1962.csv|Broom_S605.csv|Saraboji_S2204.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 273 | ARTICLE | Three-state thermodynamic analysis of the denaturation of staphylococcal nuclease mutants. | 1,994 | 10.1021/bi00201a035 | 8075087 | Biochemistry;33;10842-50 | 3 | Privalov P L|Carra J H|Anderson E A | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"IO... | [{"datasets":["AUTOMUTE_S1962.csv","Broom_S605.csv","Saraboji_S2204.csv"],"id":11038,"numValue":46.3,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Broom_S605.csv","Saraboji_S1791.csv","Saraboji_S2204.csv"],"id":11039,"numValue":-7.8,"references":[],"strValue":null,... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||
fireprotdb:7011 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,011 | train | mutant | 1,594 | 117 | 1,794 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148W | V148W | 1 | 1 | 0 | 0 | 148 | V | W | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 3,038 | ProTherm | 7 | DSC | Thermal | Sodium phosphate | 20 mM | null | NaCl | 100 mM | 1STN_A:V66W | 50.8 | null | null | null | 67 | null | null | null | null | null | null | null | null | null | null | null | yes | 3.0 | TM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 273 | ARTICLE | Three-state thermodynamic analysis of the denaturation of staphylococcal nuclease mutants. | 1,994 | 10.1021/bi00201a035 | 8075087 | Biochemistry;33;10842-50 | 3 | Privalov P L|Carra J H|Anderson E A | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"IO... | [{"datasets":[],"id":11043,"numValue":50.8,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":11044,"numValue":67.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":11045,"numValue":3.0,"references":[],"strValue":null,"type":"STATE"},{"datasets":[],"id":11046,"numValue":null,"references":[... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7012 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,012 | train | mutant | 1,594 | 117 | 1,794 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148W | V148W | 1 | 1 | 0 | 0 | 148 | V | W | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 3,509 | ProTherm | 7 | CD | Thermal | PIPES | 0.05 mM | null | 1STN_A:V66W | 43.1 | -10 | null | null | null | null | 42.8 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 320 | ARTICLE | Thermodynamics of the unfolding and spectroscopic properties of the V66W mutant of Staphylococcal nuclease and its 1-136 fragment. | 1,996 | 10.1021/bi9530090 | 8672513 | Biochemistry;35;8084-94 | 6 | Ionescu R|Eftink M R|Ramsay G D|Wong C Y|Wu J Q|Maki A H | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"PIPES","type":"BUFFER"},{"numValue":null,"strValue":"0.05 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1STN_A:V66W","type":"_PDB_... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":12908,"numValue":43.1,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":12909,"numValue":-10.0,"references":[],"strValue":nu... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:7013 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,013 | train | mutant | 1,594 | 117 | 1,794 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148W | V148W | 1 | 1 | 0 | 0 | 148 | V | W | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 11,356 | ProTherm | 7.3 | CD | GdnHCl | phosphate | 20 mM | 25 | 1STN_A:V66W | null | null | 1.3 | null | null | null | null | 0.34 | 3.87 | null | null | null | null | null | null | null | Unknown | DG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 759 | ARTICLE | Incorporation of tryptophan analogues into staphylococcal nuclease: stability toward thermal and guanidine-HCl induced unfolding. | 1,998 | 10.1021/bi971863g | 9636036 | Biochemistry;37;8947-53 | 2 | Eftink M R|Wong C Y | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CO... | [{"datasets":[],"id":39085,"numValue":1.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":39086,"numValue":3.87,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":39087,"numValue":0.34,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":39088,"numValue":null,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:7014 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,014 | train | mutant | 1,594 | 117 | 1,794 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148W | V148W | 1 | 1 | 0 | 0 | 148 | V | W | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 11,357 | ProTherm | 7.3 | CD | GdnHCl | phosphate | 20 mM | 25 | 1STN_A:V66W | null | null | 2.26 | null | null | null | null | 0.42 | 5.32 | null | null | null | null | null | null | null | Unknown | 3.0 | DG|M|CM|STATE|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 759 | ARTICLE | Incorporation of tryptophan analogues into staphylococcal nuclease: stability toward thermal and guanidine-HCl induced unfolding. | 1,998 | 10.1021/bi971863g | 9636036 | Biochemistry;37;8947-53 | 2 | Eftink M R|Wong C Y | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CO... | [{"datasets":[],"id":39089,"numValue":2.26,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":39090,"numValue":5.32,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":39091,"numValue":0.42,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":39092,"numValue":3.0,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:7015 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,015 | train | mutant | 1,594 | 117 | 1,794 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148W | V148W | 1 | 1 | 0 | 0 | 148 | V | W | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 11,358 | ProTherm | 7.3 | CD | GdnHCl | phosphate | 20 mM | 25 | 1STN_A:V66W | null | null | 2.75 | null | null | null | null | 0.92 | 2.98 | null | null | null | null | null | null | null | Unknown | 3.0 | DG|M|CM|STATE|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 759 | ARTICLE | Incorporation of tryptophan analogues into staphylococcal nuclease: stability toward thermal and guanidine-HCl induced unfolding. | 1,998 | 10.1021/bi971863g | 9636036 | Biochemistry;37;8947-53 | 2 | Eftink M R|Wong C Y | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CO... | [{"datasets":[],"id":39094,"numValue":2.75,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":39095,"numValue":2.98,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":39096,"numValue":0.92,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":39097,"numValue":3.0,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:7016 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,016 | train | mutant | 1,594 | 117 | 1,794 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148W | V148W | 1 | 1 | 0 | 0 | 148 | V | W | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 13,305 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66W | null | null | 2.32 | 3.01 | null | null | null | 0.35 | 6.6 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 265 | ARTICLE | The phase transition between a compact denatured state and a random coil state in staphylococcal nuclease is first-order. | 1,993 | 10.1006/jmbi.1993.1425 | 8355268 | J Mol Biol;232;718-24 | 3 | Gittis A G|Stites W E|Lattman E E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":48881,"numValue":2.32,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S983.csv"],"id":48882,"numValue":3.01,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48883,"numValue":6.6,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48884,"numValue":0.35,... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7017 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,017 | train | mutant | 1,594 | 117 | 1,794 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148W | V148W | 1 | 1 | 0 | 0 | 148 | V | W | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 13,308 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66W | null | null | 1.66 | 3.36 | null | null | null | 0.74 | 2.45 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 265 | ARTICLE | The phase transition between a compact denatured state and a random coil state in staphylococcal nuclease is first-order. | 1,993 | 10.1006/jmbi.1993.1425 | 8355268 | J Mol Biol;232;718-24 | 3 | Gittis A G|Stites W E|Lattman E E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":48896,"numValue":1.66,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48897,"numValue":3.36,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48898,"numValue":2.45,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48899,"numValue":0.74,"references":[],... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7018 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,018 | train | mutant | 1,594 | 117 | 1,794 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148W | V148W | 1 | 1 | 0 | 0 | 148 | V | W | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 13,477 | ProTherm | 7 | CD | GdnHCl | PIPES | 0.05 mM | 20 | 1STN_A:V66W | null | null | 1.3 | 4.02 | null | null | null | null | 3.87 | null | null | null | null | null | null | null | yes | DG|DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 320 | ARTICLE | Thermodynamics of the unfolding and spectroscopic properties of the V66W mutant of Staphylococcal nuclease and its 1-136 fragment. | 1,996 | 10.1021/bi9530090 | 8672513 | Biochemistry;35;8084-94 | 6 | Ionescu R|Eftink M R|Ramsay G D|Wong C Y|Wu J Q|Maki A H | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"PIPES","type":"BUFFER"},{"numValue":null,"strValue":"0.05 mM","type":"BUFFER_CONC... | [{"datasets":[],"id":49732,"numValue":1.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":49733,"numValue":4.02,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49734,"numValue":3.87,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":49735,"numValue":null,"references":[],"... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:7019 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,019 | train | mutant | 1,597 | 117 | 1,797 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148A | V148A | 1 | 1 | 0 | 0 | 148 | V | A | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 2,993 | ProTherm | 7 | CD | Thermal | Sodium phosphate | 20 mM | null | NaCl | 100 mM | 1STN_A:V66A | 42.2 | -11.9 | null | null | null | 1.97 | 59.33 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DCP|DHVH|REVERSIBILITY | Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv|AUTOMUTE_S1962.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 266 | ARTICLE | Thermodynamics of staphylococcal nuclease denaturation. II. The A-state. | 1,994 | 10.1002/pro.5560030610 | 8069224 | Protein Sci;3;952-9 | 3 | Privalov P L|Carra J H|Anderson E A | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION... | [{"datasets":["Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10866,"numValue":42.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10867,"numValue":-11.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":["AUTOMUTE_S1... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7020 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,020 | train | mutant | 1,597 | 117 | 1,797 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148A | V148A | 1 | 1 | 0 | 0 | 148 | V | A | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 3,043 | ProTherm | 5 | DSC | Thermal | Sodium acetate | 20 mM | null | NaCl | 100 mM | 1STN_A:V66A | 36.3 | -14.5 | null | null | 38.3 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 274 | ARTICLE | Thermodynamics of staphylococcal nuclease denaturation. I. The acid-denatured state. | 1,994 | 10.1002/pro.5560030609 | 8069223 | Protein Sci;3;944-51 | 3 | Privalov P L|Carra J H|Anderson E A | [{"numValue":5.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":11065,"numValue":36.3,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv"],"id":11066,"numValue":-14.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":["AUTOM... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7021 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,021 | train | mutant | 1,597 | 117 | 1,797 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148A | V148A | 1 | 1 | 0 | 0 | 148 | V | A | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 3,044 | ProTherm | 6 | DSC | Thermal | Sodium acetate | 20 mM | null | NaCl | 100 mM | 1STN_A:V66A | 41.2 | -12.2 | null | null | 53.8 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 274 | ARTICLE | Thermodynamics of staphylococcal nuclease denaturation. I. The acid-denatured state. | 1,994 | 10.1002/pro.5560030609 | 8069223 | Protein Sci;3;944-51 | 3 | Privalov P L|Carra J H|Anderson E A | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":11069,"numValue":41.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv"],"id":11070,"numValue":-12.2,"references":[],"strValue":null,"type":"DTM"},{"datasets":["AUTOM... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7022 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,022 | train | mutant | 1,597 | 117 | 1,797 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148A | V148A | 1 | 1 | 0 | 0 | 148 | V | A | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 3,045 | ProTherm | 7 | DSC | Thermal | Sodium phosphate | 20 mM | null | NaCl | 100 mM | 1STN_A:V66A | 42.2 | -11.9 | null | null | 59.3 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 274 | ARTICLE | Thermodynamics of staphylococcal nuclease denaturation. I. The acid-denatured state. | 1,994 | 10.1002/pro.5560030609 | 8069223 | Protein Sci;3;944-51 | 3 | Privalov P L|Carra J H|Anderson E A | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"IO... | [{"datasets":[],"id":11073,"numValue":42.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":11074,"numValue":-11.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":11075,"numValue":59.3,"references":[],"strValue":null,"type":"DH"},{"datasets":[],... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7023 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,023 | train | mutant | 1,597 | 117 | 1,797 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148A | V148A | 1 | 1 | 0 | 0 | 148 | V | A | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 3,046 | ProTherm | 8 | DSC | Thermal | Sodium phosphate | 20 mM | null | NaCl | 100 mM | 1STN_A:V66A | 42.4 | -11.1 | null | null | 60.3 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 274 | ARTICLE | Thermodynamics of staphylococcal nuclease denaturation. I. The acid-denatured state. | 1,994 | 10.1002/pro.5560030609 | 8069223 | Protein Sci;3;944-51 | 3 | Privalov P L|Carra J H|Anderson E A | [{"numValue":8.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"IO... | [{"datasets":[],"id":11077,"numValue":42.4,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":11078,"numValue":-11.1,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":11079,"numValue":60.3,"references":[],"strValue":null,"type":"DH"},{"datasets":[],... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7024 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,024 | train | mutant | 1,597 | 117 | 1,797 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148A | V148A | 1 | 1 | 0 | 0 | 148 | V | A | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 12,703 | ProTherm | 7 | Fluorescence | Pressure | Bis-Tris | 10 mM | 21 | 1STN_A:V66A | null | null | 2.2 | null | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 817 | ARTICLE | Probing the contribution of internal cavities to the volume change of protein unfolding under pressure. | 1,998 | 10.1002/pro.5560071020 | 9792110 | Protein Sci;7;2217-22 | 2 | Royer C A|Frye K J | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":21.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Pressure","type":"METHOD"},{"numValue":null,"strValue":"Bis-Tris","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type"... | [{"datasets":[],"id":46070,"numValue":2.2,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":46071,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:7025 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,025 | train | mutant | 1,597 | 117 | 1,797 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148A | V148A | 1 | 1 | 0 | 0 | 148 | V | A | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 13,426 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66A | null | null | 3.28 | 2.2 | null | null | null | 0.4 | 1.1 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 850 | ARTICLE | Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease. | 1,990 | 10.1021/bi00487a007 | 2261461 | Biochemistry;29;8033-41 | 3 | Shortle D|Stites W E|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":49478,"numValue":3.28,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":49479,"numValue":2.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49480,"numValue":1.1,"references":[],"strValue":nu... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7026 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,026 | train | mutant | 5,871 | 117 | 6,440 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148G | V148G | 1 | 1 | 0 | 0 | 148 | V | G | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 12,702 | ProTherm | 7 | Fluorescence | Pressure | Bis-Tris | 10 mM | 21 | 1STN_A:V66G | null | null | 2 | null | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 817 | ARTICLE | Probing the contribution of internal cavities to the volume change of protein unfolding under pressure. | 1,998 | 10.1002/pro.5560071020 | 9792110 | Protein Sci;7;2217-22 | 2 | Royer C A|Frye K J | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":21.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Pressure","type":"METHOD"},{"numValue":null,"strValue":"Bis-Tris","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type"... | [{"datasets":[],"id":46068,"numValue":2.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":46069,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:7027 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,027 | train | mutant | 5,871 | 117 | 6,440 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148G | V148G | 1 | 1 | 0 | 0 | 148 | V | G | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 13,427 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66G | null | null | 1.08 | 4.4 | null | null | null | 0.1 | 1.17 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 850 | ARTICLE | Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease. | 1,990 | 10.1021/bi00487a007 | 2261461 | Biochemistry;29;8033-41 | 3 | Shortle D|Stites W E|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":49483,"numValue":1.08,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":49484,"numValue":4.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49485,"numValue":1.17,"references":[],"strValue":n... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7030 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,030 | train | mutant | 5,942 | 117 | 6,512 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148M | V148M | 1 | 1 | 0 | 0 | 148 | V | M | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 12,803 | ProTherm | 8.8 | Fluorescence | GdnHCl | Tris-HCl | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66M | null | null | 5.1 | 0.1 | null | null | null | 0.88 | 0.89 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 826 | ARTICLE | In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core. | 1,991 | 10.1016/0022-2836(91)80195-z | 1920420 | J Mol Biol;221;7-14 | 4 | Shortle D|Gittis A G|Stites W E|Lattman E E | [{"numValue":8.8,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"... | [{"datasets":[],"id":46536,"numValue":5.1,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":46537,"numValue":0.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46538,"numValue":0.89,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":4653... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7031 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,031 | train | mutant | 5,942 | 117 | 6,512 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148M | V148M | 1 | 1 | 0 | 0 | 148 | V | M | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 12,805 | ProTherm | 9.6 | Fluorescence | GdnHCl | ethanolamine-HCl | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66M | null | null | 4.4 | 0.1 | null | null | null | 0.77 | 0.86 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 826 | ARTICLE | In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core. | 1,991 | 10.1016/0022-2836(91)80195-z | 1920420 | J Mol Biol;221;7-14 | 4 | Shortle D|Gittis A G|Stites W E|Lattman E E | [{"numValue":9.6,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"ethanolamine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":46546,"numValue":4.4,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":46547,"numValue":0.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46548,"numValue":0.86,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":4654... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7032 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,032 | train | mutant | 5,943 | 117 | 6,513 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148K | V148K | 1 | 1 | 0 | 0 | 148 | V | K | 8 | CONSERVATION | 1STN | 140 | null | 148 | A | H | true | false | 2.6959 | 13.088571 | 12,804 | ProTherm | 8.8 | Fluorescence | GdnHCl | Tris-HCl | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66K | null | null | 0 | 5.2 | null | null | null | 0 | 1.24 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 826 | ARTICLE | In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core. | 1,991 | 10.1016/0022-2836(91)80195-z | 1920420 | J Mol Biol;221;7-14 | 4 | Shortle D|Gittis A G|Stites W E|Lattman E E | [{"numValue":8.8,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"... | [{"datasets":[],"id":46541,"numValue":0.0,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":46542,"numValue":5.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46543,"numValue":1.24,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":46544,"numValue":0.0,"... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7034 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,034 | train | mutant | 6,711 | 117 | 7,353 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G170V | V148L|G170V | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|170 | A | H|E | true | false | 1.549506 | 10.844286 | 14,462 | ProTherm | 7 | DSC | Thermal | phosphate | 0.05 M | null | NaCl | 0.1 M | 1STN_A:V66L 1STN_A:G88V | 57.8 | 6.4 | null | null | 54.5 | 1.22 | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|DCP|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 16 | ARTICLE | Thermal unfolding of staphylococcal nuclease and several mutant forms thereof studied by differential scanning calorimetry. | 1,993 | 10.1002/pro.5560020408 | 8518730 | Protein Sci;2;567-76 | 3 | Tanaka A|Sturtevant J M|Flanagan J | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"0.05 M","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"... | [{"datasets":[],"id":53459,"numValue":57.8,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":53460,"numValue":6.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":53461,"numValue":54.5,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":53462,"numValue":1.22,"references":[],... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7035 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,035 | train | mutant | 6,711 | 117 | 7,353 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G170V | V148L|G170V | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|170 | A | H|E | true | false | 1.549506 | 10.844286 | 14,464 | ProTherm | 5 | DSC | Thermal | phosphate | 0.05 M | null | NaCl | 0.1 M | 1STN_A:V66L 1STN_A:G88V | 57.9 | 10.9 | null | null | 25.3 | 0.97 | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|DCP|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 16 | ARTICLE | Thermal unfolding of staphylococcal nuclease and several mutant forms thereof studied by differential scanning calorimetry. | 1,993 | 10.1002/pro.5560020408 | 8518730 | Protein Sci;2;567-76 | 3 | Tanaka A|Sturtevant J M|Flanagan J | [{"numValue":5.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"0.05 M","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"... | [{"datasets":[],"id":53469,"numValue":57.9,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":53470,"numValue":10.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":53471,"numValue":25.3,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":53472,"numValue":0.97,"references":[]... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7037 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,037 | train | mutant | 6,711 | 117 | 7,353 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G170V | V148L|G170V | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|170 | A | H|E | true | false | 1.549506 | 10.844286 | 15,066 | ProTherm | 5 | DSC | Thermal | phosphate | 0.05 M | 47 | NaCl | 0.1 M | 1STN_A:V66L 1STN_A:G88V | null | null | null | -1.2 | null | 0.97 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 16 | ARTICLE | Thermal unfolding of staphylococcal nuclease and several mutant forms thereof studied by differential scanning calorimetry. | 1,993 | 10.1002/pro.5560020408 | 8518730 | Protein Sci;2;567-76 | 3 | Tanaka A|Sturtevant J M|Flanagan J | [{"numValue":5.0,"strValue":null,"type":"PH"},{"numValue":47.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"0.05 M","type":"BUFFER... | [{"datasets":[],"id":55327,"numValue":0.97,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55328,"numValue":-1.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55329,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7039 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,039 | train | mutant | 6,711 | 117 | 7,353 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G170V | V148L|G170V | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|170 | A | H|E | true | false | 1.549506 | 10.844286 | 15,538 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:G88V | null | null | null | 2 | null | null | null | null | 0.57 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57028,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57029,"numValue":0.57,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57030,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7040 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,040 | train | mutant | 6,711 | 117 | 7,353 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G170V | V148L|G170V | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|170 | A | H|E | true | false | 1.549506 | 10.844286 | 15,586 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:G88V | null | null | 3.5 | 2.1 | null | null | null | 0.89 | 0.57 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 843 | ARTICLE | Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation. | 1,986 | 10.1002/prot.340010113 | 3449854 | Proteins;1;81-9 | 2 | Shortle D|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57174,"numValue":3.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":57175,"numValue":2.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57176,"numValue":0.57,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57177,"numValue":0.89,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7041 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,041 | train | mutant | 6,711 | 117 | 7,353 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G170V | V148L|G170V | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|170 | A | H|E | true | false | 1.549506 | 10.844286 | 15,591 | ProTherm | 7 | Fluorescence | Urea | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:G88V | null | null | 4.7 | 1.4 | null | null | null | 3.17 | 0.75 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 843 | ARTICLE | Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation. | 1,986 | 10.1002/prot.340010113 | 3449854 | Proteins;1;81-9 | 2 | Shortle D|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","t... | [{"datasets":[],"id":57199,"numValue":4.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":57200,"numValue":1.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57201,"numValue":0.75,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57202,"numValue":3.17,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7042 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,042 | train | mutant | 6,712 | 117 | 7,354 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G161S|G170V | V148L|G161S|G170V | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|161|170 | A | H|S|E | true | false | 7.351935 | 11.52369 | 14,463 | ProTherm | 7 | DSC | Thermal | phosphate | 0.05 M | null | NaCl | 0.1 M | 1STN_A:V66L 1STN_A:G79S 1STN_A:G88V | 56.1 | 4.7 | null | null | 26.5 | 2.22 | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|DCP|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 16 | ARTICLE | Thermal unfolding of staphylococcal nuclease and several mutant forms thereof studied by differential scanning calorimetry. | 1,993 | 10.1002/pro.5560020408 | 8518730 | Protein Sci;2;567-76 | 3 | Tanaka A|Sturtevant J M|Flanagan J | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"0.05 M","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"... | [{"datasets":[],"id":53464,"numValue":56.1,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":53465,"numValue":4.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":53466,"numValue":26.5,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":53467,"numValue":2.22,"references":[],... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7931,"numValue":6.0,"position":161,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7043 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,043 | train | mutant | 6,712 | 117 | 7,354 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G161S|G170V | V148L|G161S|G170V | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|161|170 | A | H|S|E | true | false | 7.351935 | 11.52369 | 14,465 | ProTherm | 5 | DSC | Thermal | phosphate | 0.05 M | null | NaCl | 0.1 M | 1STN_A:V66L 1STN_A:G79S 1STN_A:G88V | 54.3 | 7.3 | null | null | 12.3 | 1.78 | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|DCP|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 16 | ARTICLE | Thermal unfolding of staphylococcal nuclease and several mutant forms thereof studied by differential scanning calorimetry. | 1,993 | 10.1002/pro.5560020408 | 8518730 | Protein Sci;2;567-76 | 3 | Tanaka A|Sturtevant J M|Flanagan J | [{"numValue":5.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"0.05 M","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"... | [{"datasets":[],"id":53474,"numValue":54.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":53475,"numValue":7.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":53476,"numValue":12.3,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":53477,"numValue":1.78,"references":[],... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7931,"numValue":6.0,"position":161,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7044 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,044 | train | mutant | 6,712 | 117 | 7,354 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G161S|G170V | V148L|G161S|G170V | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|161|170 | A | H|S|E | true | false | 7.351935 | 11.52369 | 14,678 | ProTherm | 7 | DSC | Thermal | Sodium phosphate | 20 mM | null | NaCl | 100 mM | 1STN_A:V66L 1STN_A:G79S 1STN_A:G88V | 57.6 | 3.5 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 268 | ARTICLE | Energetics of denaturation and m values of staphylococcal nuclease mutants. | 1,995 | 10.1021/bi00006a025 | 7849061 | Biochemistry;34;2034-41 | 2 | Privalov P L|Carra J H | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"IO... | [{"datasets":[],"id":54286,"numValue":57.6,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":54287,"numValue":3.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":54288,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7931,"numValue":6.0,"position":161,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7045 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,045 | train | mutant | 6,712 | 117 | 7,354 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G161S|G170V | V148L|G161S|G170V | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|161|170 | A | H|S|E | true | false | 7.351935 | 11.52369 | 15,065 | ProTherm | 7 | DSC | Thermal | phosphate | 0.05 M | 47 | NaCl | 0.1 M | 1STN_A:V66L 1STN_A:G79S 1STN_A:G88V | null | null | null | -0.3 | null | 2.22 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 16 | ARTICLE | Thermal unfolding of staphylococcal nuclease and several mutant forms thereof studied by differential scanning calorimetry. | 1,993 | 10.1002/pro.5560020408 | 8518730 | Protein Sci;2;567-76 | 3 | Tanaka A|Sturtevant J M|Flanagan J | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":47.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"0.05 M","type":"BUFFER... | [{"datasets":[],"id":55324,"numValue":2.22,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55325,"numValue":-0.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55326,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7931,"numValue":6.0,"position":161,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7046 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,046 | train | mutant | 6,712 | 117 | 7,354 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G161S|G170V | V148L|G161S|G170V | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|161|170 | A | H|S|E | true | false | 7.351935 | 11.52369 | 15,067 | ProTherm | 5 | DSC | Thermal | phosphate | 0.05 M | 47 | NaCl | 0.1 M | 1STN_A:V66L 1STN_A:G79S 1STN_A:G88V | null | null | null | -0.5 | null | 1.78 | null | null | null | null | null | null | null | null | null | null | yes | DCP|DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 16 | ARTICLE | Thermal unfolding of staphylococcal nuclease and several mutant forms thereof studied by differential scanning calorimetry. | 1,993 | 10.1002/pro.5560020408 | 8518730 | Protein Sci;2;567-76 | 3 | Tanaka A|Sturtevant J M|Flanagan J | [{"numValue":5.0,"strValue":null,"type":"PH"},{"numValue":47.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"0.05 M","type":"BUFFER... | [{"datasets":[],"id":55330,"numValue":1.78,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":55331,"numValue":-0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55332,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7931,"numValue":6.0,"position":161,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7047 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,047 | train | mutant | 6,712 | 117 | 7,354 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G161S|G170V | V148L|G161S|G170V | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|161|170 | A | H|S|E | true | false | 7.351935 | 11.52369 | 15,511 | ProTherm | 7 | Fluorescence | GdnHCl | Na3PO4 | 25 mM | 20 | NaCl | 0.1 M | 1STN_A:V66L 1STN_A:G79S 1STN_A:G88V | null | null | 2.6 | 3 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 837 | ARTICLE | Stability mutants of staphylococcal nuclease: large compensating enthalpy-entropy changes for the reversible denaturation reaction. | 1,988 | 10.1021/bi00413a027 | 3167015 | Biochemistry;27;4761-8 | 3 | Freire E|Shortle D|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Na3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":56945,"numValue":2.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":56946,"numValue":3.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":56947,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7931,"numValue":6.0,"position":161,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7048 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,048 | train | mutant | 6,712 | 117 | 7,354 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G161S|G170V | V148L|G161S|G170V | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|161|170 | A | H|S|E | true | false | 7.351935 | 11.52369 | 15,587 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:G79S 1STN_A:G88V | null | null | 2.6 | 3 | null | null | null | 0.76 | 0.51 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 843 | ARTICLE | Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation. | 1,986 | 10.1002/prot.340010113 | 3449854 | Proteins;1;81-9 | 2 | Shortle D|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57179,"numValue":2.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":57180,"numValue":3.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57181,"numValue":0.51,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57182,"numValue":0.76,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7931,"numValue":6.0,"position":161,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7049 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,049 | train | mutant | 6,712 | 117 | 7,354 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G161S|G170V | V148L|G161S|G170V | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|161|170 | A | H|S|E | true | false | 7.351935 | 11.52369 | 15,592 | ProTherm | 7 | Fluorescence | Urea | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:G79S 1STN_A:G88V | null | null | 2.7 | 3.4 | null | null | null | 2.61 | 0.57 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 843 | ARTICLE | Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation. | 1,986 | 10.1002/prot.340010113 | 3449854 | Proteins;1;81-9 | 2 | Shortle D|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","t... | [{"datasets":[],"id":57204,"numValue":2.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":57205,"numValue":3.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57206,"numValue":0.57,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57207,"numValue":2.61,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7931,"numValue":6.0,"position":161,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7940,"numValue":6.0,"position":170,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7050 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,050 | train | mutant | 7,275 | 117 | 7,930 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G161S | V148L|G161S | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|161 | A | H|S | true | false | 10.826347 | 12.985536 | 15,585 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:G79S | null | null | 2.3 | 3.3 | null | null | null | 0.56 | 0.61 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 843 | ARTICLE | Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation. | 1,986 | 10.1002/prot.340010113 | 3449854 | Proteins;1;81-9 | 2 | Shortle D|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57169,"numValue":2.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":57170,"numValue":3.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57171,"numValue":0.61,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57172,"numValue":0.56,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7931,"numValue":6.0,"position":161,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7051 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,051 | train | mutant | 7,275 | 117 | 7,930 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|G161S | V148L|G161S | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|161 | A | H|S | true | false | 10.826347 | 12.985536 | 15,590 | ProTherm | 7 | Fluorescence | Urea | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:G79S | null | null | 2.5 | 3.6 | null | null | null | 1.88 | 0.7 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 843 | ARTICLE | Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation. | 1,986 | 10.1002/prot.340010113 | 3449854 | Proteins;1;81-9 | 2 | Shortle D|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","t... | [{"datasets":[],"id":57194,"numValue":2.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":57195,"numValue":3.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57196,"numValue":0.7,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57197,"numValue":1.88,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7931,"numValue":6.0,"position":161,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7052 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,052 | train | mutant | 8,013 | 117 | 8,740 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I174V|V181I | V148I|I174V|V181I | 3 | 3 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|174|181 | A | H|E | true | false | 1.391327 | 9.685059 | 17,165 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I92V 1STN_A:V99I | null | null | 4.9 | 0.5 | null | null | null | 0.75 | 6.53 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63229,"numValue":4.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63230,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63231,"numValue":6.53,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63232,"numValue":0.75,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7053 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,053 | train | mutant | 8,014 | 117 | 8,741 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I174V|V181I | V148L|I174V|V181I | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|174|181 | A | H|E | true | false | 1.391327 | 9.685059 | 17,166 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I92V 1STN_A:V99I | null | null | 5 | 0.4 | null | null | null | 0.85 | 5.94 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63234,"numValue":5.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63235,"numValue":0.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63236,"numValue":5.94,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63237,"numValue":0.85,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7055 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,055 | train | mutant | 8,016 | 117 | 8,743 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I174V|V181L | V148L|I174V|V181L | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|174|181 | A | H|E | true | false | 1.391327 | 9.685059 | 17,168 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I92V 1STN_A:V99L | null | null | 5.5 | -0.1 | null | null | null | 0.9 | 6.14 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63244,"numValue":5.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63245,"numValue":-0.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63246,"numValue":6.14,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63247,"numValue":0.9,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7056 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,056 | train | mutant | 8,017 | 117 | 8,744 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I174L|V181L | V148L|I174L|V181L | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|174|181 | A | H|E | true | false | 1.391327 | 9.685059 | 17,169 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I92L 1STN_A:V99L | null | null | 4.7 | 0.7 | null | null | null | 0.79 | 5.88 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63249,"numValue":4.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63250,"numValue":0.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63251,"numValue":5.88,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63252,"numValue":0.79,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7057 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,057 | train | mutant | 8,018 | 117 | 8,745 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I174L|V181L | V148I|I174L|V181L | 3 | 3 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|174|181 | A | H|E | true | false | 1.391327 | 9.685059 | 17,170 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I92L 1STN_A:V99L | null | null | 3.3 | 2.1 | null | null | null | 0.53 | 6.2 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63254,"numValue":3.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63255,"numValue":2.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63256,"numValue":6.2,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63257,"numValue":0.53,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7058 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,058 | train | mutant | 8,019 | 117 | 8,746 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I174L|V181I | V148L|I174L|V181I | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|174|181 | A | H|E | true | false | 1.391327 | 9.685059 | 17,171 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I92L 1STN_A:V99I | null | null | 4 | 1.4 | null | null | null | 0.71 | 5.55 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63259,"numValue":4.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63260,"numValue":1.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63261,"numValue":5.55,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63262,"numValue":0.71,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7059 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,059 | train | mutant | 8,020 | 117 | 8,747 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I174L|V181I | V148I|I174L|V181I | 3 | 3 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|174|181 | A | H|E | true | false | 1.391327 | 9.685059 | 17,172 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I92L 1STN_A:V99I | null | null | 3.3 | 2.1 | null | null | null | 0.57 | 5.74 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63264,"numValue":3.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63265,"numValue":2.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63266,"numValue":5.74,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63267,"numValue":0.57,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7061 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,061 | train | mutant | 8,046 | 117 | 8,773 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154V|I174L | V148I|I154V|I174L | 3 | 3 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174 | A | H|E | true | false | 5.680885 | 10.98494 | 17,198 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72V 1STN_A:I92L | null | null | 3.4 | 2 | null | null | null | 0.5 | 6.79 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63394,"numValue":3.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63395,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63396,"numValue":6.79,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63397,"numValue":0.5,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7062 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,062 | train | mutant | 8,047 | 117 | 8,774 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154L|I174L | V148L|I154L|I174L | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174 | A | H|E | true | false | 5.680885 | 10.98494 | 17,199 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72L 1STN_A:I92L | null | null | 3.9 | 1.5 | null | null | null | 0.66 | 6 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63399,"numValue":3.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63400,"numValue":1.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63401,"numValue":6.0,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63402,"numValue":0.66,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7063 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,063 | train | mutant | 8,048 | 117 | 8,775 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154V|I174L | V148L|I154V|I174L | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174 | A | H|E | true | false | 5.680885 | 10.98494 | 17,200 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72V 1STN_A:I92L | null | null | 4.1 | 1.3 | null | null | null | 0.65 | 6.27 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63404,"numValue":4.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63405,"numValue":1.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63406,"numValue":6.27,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63407,"numValue":0.65,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7064 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,064 | train | mutant | 8,049 | 117 | 8,776 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154L|I174V | V148I|I154L|I174V | 3 | 3 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174 | A | H|E | true | false | 5.680885 | 10.98494 | 17,201 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72L 1STN_A:I92V | null | null | 4 | 1.4 | null | null | null | 0.61 | 6.53 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63409,"numValue":4.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63410,"numValue":1.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63411,"numValue":6.53,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63412,"numValue":0.61,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7065 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,065 | train | mutant | 8,050 | 117 | 8,777 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154V|I174V | V148I|I154V|I174V | 3 | 3 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174 | A | H|E | true | false | 5.680885 | 10.98494 | 17,202 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72V 1STN_A:I92V | null | null | 4 | 1.4 | null | null | null | 0.59 | 6.79 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63414,"numValue":4.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63415,"numValue":1.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63416,"numValue":6.79,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63417,"numValue":0.59,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7066 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,066 | train | mutant | 8,051 | 117 | 8,778 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154L|I174V | V148L|I154L|I174V | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174 | A | H|E | true | false | 5.680885 | 10.98494 | 17,203 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72L 1STN_A:I92V | null | null | 4.6 | 0.8 | null | null | null | 0.69 | 6.6 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63419,"numValue":4.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63420,"numValue":0.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63421,"numValue":6.6,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63422,"numValue":0.69,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7067 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,067 | train | mutant | 8,052 | 117 | 8,779 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154V|I174V | V148L|I154V|I174V | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174 | A | H|E | true | false | 5.680885 | 10.98494 | 17,204 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72V 1STN_A:I92V | null | null | 4.9 | 0.5 | null | null | null | 0.75 | 6.6 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63424,"numValue":4.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63425,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63426,"numValue":6.6,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63427,"numValue":0.75,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7068 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,068 | train | mutant | 8,053 | 117 | 8,780 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154L|V181L | V148I|I154L|V181L | 3 | 3 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|181 | A | H|E | true | false | 5.546514 | 10.104643 | 17,205 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72L 1STN_A:V99L | null | null | 3.5 | 1.9 | null | null | null | 0.58 | 6 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63429,"numValue":3.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63430,"numValue":1.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63431,"numValue":6.0,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63432,"numValue":0.58,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7069 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,069 | train | mutant | 8,054 | 117 | 8,781 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154V|V181L | V148I|I154V|V181L | 3 | 3 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|181 | A | H|E | true | false | 5.546514 | 10.104643 | 17,206 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72V 1STN_A:V99L | null | null | 3.8 | 1.6 | null | null | null | 0.6 | 6.4 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63434,"numValue":3.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63435,"numValue":1.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63436,"numValue":6.4,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63437,"numValue":0.6,"references":[],"str... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7070 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,070 | train | mutant | 8,055 | 117 | 8,782 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154L|V181L | V148L|I154L|V181L | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|181 | A | H|E | true | false | 5.546514 | 10.104643 | 17,207 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72L 1STN_A:V99L | null | null | 4.6 | 0.8 | null | null | null | 0.78 | 5.88 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63439,"numValue":4.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63440,"numValue":0.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63441,"numValue":5.88,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63442,"numValue":0.78,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7071 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,071 | train | mutant | 8,056 | 117 | 8,783 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154V|V181L | V148L|I154V|V181L | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|181 | A | H|E | true | false | 5.546514 | 10.104643 | 17,208 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72V 1STN_A:V99L | null | null | 4.9 | 0.5 | null | null | null | 0.79 | 6.14 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63444,"numValue":4.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63445,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63446,"numValue":6.14,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63447,"numValue":0.79,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7072 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,072 | train | mutant | 8,057 | 117 | 8,784 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154L|V181I | V148I|I154L|V181I | 3 | 3 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|181 | A | H|E | true | false | 5.546514 | 10.104643 | 17,209 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72L 1STN_A:V99I | null | null | 3.5 | 1.9 | null | null | null | 0.63 | 5.55 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63449,"numValue":3.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63450,"numValue":1.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63451,"numValue":5.55,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63452,"numValue":0.63,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7073 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,073 | train | mutant | 8,058 | 117 | 8,785 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154V|V181I | V148I|I154V|V181I | 3 | 3 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|181 | A | H|E | true | false | 5.546514 | 10.104643 | 17,210 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72V 1STN_A:V99I | null | null | 4.6 | 0.8 | null | null | null | 0.73 | 6.4 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63454,"numValue":4.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63455,"numValue":0.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63456,"numValue":6.4,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63457,"numValue":0.73,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7074 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,074 | train | mutant | 8,059 | 117 | 8,786 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154L|V181I | V148L|I154L|V181I | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|181 | A | H|E | true | false | 5.546514 | 10.104643 | 17,211 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72L 1STN_A:V99I | null | null | 4.4 | 1 | null | null | null | 0.75 | 5.88 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63459,"numValue":4.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63460,"numValue":1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63461,"numValue":5.88,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63462,"numValue":0.75,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7075 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,075 | train | mutant | 8,060 | 117 | 8,787 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154V|V181I | V148L|I154V|V181I | 3 | 3 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|181 | A | H|E | true | false | 5.546514 | 10.104643 | 17,212 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72V 1STN_A:V99I | null | null | 4.6 | 0.8 | null | null | null | 0.75 | 6.2 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63464,"numValue":4.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63465,"numValue":0.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63466,"numValue":6.2,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63467,"numValue":0.75,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7076 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,076 | train | mutant | 8,077 | 117 | 8,804 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154V|I174V|V181I | V148I|I154V|I174V|V181I | 4 | 4 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,229 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72V 1STN_A:I92V 1STN_A:V99I | null | null | 4.4 | 1 | null | null | null | 0.67 | 6.6 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63549,"numValue":4.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63550,"numValue":1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63551,"numValue":6.6,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63552,"numValue":0.67,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7077 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,077 | train | mutant | 8,078 | 117 | 8,805 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154V|I174V|V181L | V148I|I154V|I174V|V181L | 4 | 4 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,230 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72V 1STN_A:I92V 1STN_A:V99L | null | null | 3.7 | 1.7 | null | null | null | 0.54 | 6.92 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63554,"numValue":3.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63555,"numValue":1.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63556,"numValue":6.92,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63557,"numValue":0.54,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7078 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,078 | train | mutant | 8,079 | 117 | 8,806 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154V|I174L|V181I | V148I|I154V|I174L|V181I | 4 | 4 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,231 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72V 1STN_A:I92L 1STN_A:V99I | null | null | 3.4 | 2 | null | null | null | 0.51 | 6.66 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63559,"numValue":3.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63560,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63561,"numValue":6.66,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63562,"numValue":0.51,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7079 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,079 | train | mutant | 8,080 | 117 | 8,807 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154V|I174L|V181L | V148I|I154V|I174L|V181L | 4 | 4 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,232 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72V 1STN_A:I92L 1STN_A:V99L | null | null | 3 | 2.4 | null | null | null | 0.42 | 7.05 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63564,"numValue":3.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63565,"numValue":2.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63566,"numValue":7.05,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63567,"numValue":0.42,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7080 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,080 | train | mutant | 8,081 | 117 | 8,808 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154L|I174V|V181I | V148I|I154L|I174V|V181I | 4 | 4 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,233 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72L 1STN_A:I92V 1STN_A:V99I | null | null | 3.8 | 1.6 | null | null | null | 0.59 | 6.53 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63569,"numValue":3.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63570,"numValue":1.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63571,"numValue":6.53,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63572,"numValue":0.59,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7081 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,081 | train | mutant | 8,082 | 117 | 8,809 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154L|I174V|V181L | V148I|I154L|I174V|V181L | 4 | 4 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,234 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72L 1STN_A:I92V 1STN_A:V99L | null | null | 3.6 | 1.8 | null | null | null | 0.52 | 6.86 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63574,"numValue":3.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63575,"numValue":1.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63576,"numValue":6.86,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63577,"numValue":0.52,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7082 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,082 | train | mutant | 8,083 | 117 | 8,810 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154L|I174L|V181I | V148I|I154L|I174L|V181I | 4 | 4 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,235 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72L 1STN_A:I92L 1STN_A:V99I | null | null | 2.1 | 3.3 | null | null | null | 0.41 | 5.22 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63579,"numValue":2.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63580,"numValue":3.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63581,"numValue":5.22,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63582,"numValue":0.41,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7083 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,083 | train | mutant | 8,084 | 117 | 8,811 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154L|I174L|V181L | V148I|I154L|I174L|V181L | 4 | 4 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,236 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72L 1STN_A:I92L 1STN_A:V99L | null | null | 2.4 | 3 | null | null | null | 0.42 | 5.75 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63584,"numValue":2.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63585,"numValue":3.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63586,"numValue":5.75,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63587,"numValue":0.42,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7085 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,085 | train | mutant | 8,086 | 117 | 8,813 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154V|I174V|V181L | V148L|I154V|I174V|V181L | 4 | 4 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,238 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72V 1STN_A:I92V 1STN_A:V99L | null | null | 4.7 | 0.7 | null | null | null | 0.71 | 6.66 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63594,"numValue":4.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63595,"numValue":0.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63596,"numValue":6.66,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63597,"numValue":0.71,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7086 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,086 | train | mutant | 8,087 | 117 | 8,814 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154V|I174L|V181I | V148L|I154V|I174L|V181I | 4 | 4 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,239 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72V 1STN_A:I92L 1STN_A:V99I | null | null | 3.6 | 1.8 | null | null | null | 0.57 | 6.33 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63599,"numValue":3.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63600,"numValue":1.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63601,"numValue":6.33,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63602,"numValue":0.57,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7087 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,087 | train | mutant | 8,088 | 117 | 8,815 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154V|I174L|V181L | V148L|I154V|I174L|V181L | 4 | 4 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,240 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72V 1STN_A:I92L 1STN_A:V99L | null | null | 4 | 1.4 | null | null | null | 0.62 | 6.53 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63604,"numValue":4.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63605,"numValue":1.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63606,"numValue":6.53,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63607,"numValue":0.62,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7088 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,088 | train | mutant | 8,089 | 117 | 8,816 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154L|I174V|V181I | V148L|I154L|I174V|V181I | 4 | 4 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,241 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72L 1STN_A:I92V 1STN_A:V99I | null | null | 4.4 | 1 | null | null | null | 0.69 | 6.33 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63609,"numValue":4.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63610,"numValue":1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63611,"numValue":6.33,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63612,"numValue":0.69,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7089 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,089 | train | mutant | 8,090 | 117 | 8,817 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154L|I174V|V181L | V148L|I154L|I174V|V181L | 4 | 4 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,242 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72L 1STN_A:I92V 1STN_A:V99L | null | null | 4.7 | 0.7 | null | null | null | 0.71 | 6.6 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63614,"numValue":4.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63615,"numValue":0.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63616,"numValue":6.6,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63617,"numValue":0.71,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7091 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,091 | train | mutant | 8,092 | 117 | 8,819 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154L|I174L|V181L | V148L|I154L|I174L|V181L | 4 | 4 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154|174|181 | A | H|E | true | false | 4.395035 | 9.90442 | 17,244 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72L 1STN_A:I92L 1STN_A:V99L | null | null | 4.1 | 1.3 | null | null | null | 0.65 | 6.4 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63624,"numValue":4.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63625,"numValue":1.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63626,"numValue":6.4,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63627,"numValue":0.65,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:7092 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,092 | train | mutant | 8,104 | 117 | 8,831 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I154L | V148L|I154L | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|154 | A | H|E | true | false | 8.051029 | 11.825536 | 17,256 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I72L | null | null | 4.5 | 0.9 | null | null | null | 0.75 | 0.89 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 986 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles. | 2,001 | 10.1021/bi011268l | 11705392 | Biochemistry;40;14004-11 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63684,"numValue":4.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63685,"numValue":0.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63686,"numValue":0.89,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63687,"numValue":0.75,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7094 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,094 | train | mutant | 8,106 | 117 | 8,833 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154V | V148I|I154V | 2 | 2 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154 | A | H|E | true | false | 8.051029 | 11.825536 | 17,258 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72V | null | null | 4.2 | 1.2 | null | null | null | 0.63 | 0.99 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 986 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles. | 2,001 | 10.1021/bi011268l | 11705392 | Biochemistry;40;14004-11 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63694,"numValue":4.2,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63695,"numValue":1.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63696,"numValue":0.99,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63697,"numValue":0.63,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7095 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,095 | train | mutant | 8,107 | 117 | 8,834 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I154L | V148I|I154L | 2 | 2 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|154 | A | H|E | true | false | 8.051029 | 11.825536 | 17,259 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I72L | null | null | 3.7 | 1.7 | null | null | null | 0.64 | 0.87 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 986 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles. | 2,001 | 10.1021/bi011268l | 11705392 | Biochemistry;40;14004-11 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63699,"numValue":3.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63700,"numValue":1.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63701,"numValue":0.87,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63702,"numValue":0.64,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7096 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,096 | train | mutant | 8,128 | 117 | 8,855 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I174L | V148I|I174L | 2 | 2 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|174 | A | H|E | true | false | 1.818248 | 11.196161 | 17,280 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I92L | null | null | 3.5 | 1.9 | null | null | null | 0.59 | 0.88 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 986 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles. | 2,001 | 10.1021/bi011268l | 11705392 | Biochemistry;40;14004-11 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63804,"numValue":3.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63805,"numValue":1.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63806,"numValue":0.88,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63807,"numValue":0.59,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7097 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,097 | train | mutant | 8,129 | 117 | 8,856 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|I174V | V148I|I174V | 2 | 2 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|174 | A | H|E | true | false | 1.818248 | 11.196161 | 17,281 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:I92V | null | null | 4.7 | 0.7 | null | null | null | 0.69 | 1 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 986 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles. | 2,001 | 10.1021/bi011268l | 11705392 | Biochemistry;40;14004-11 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63809,"numValue":4.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63810,"numValue":0.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63811,"numValue":1.0,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63812,"numValue":0.69,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7098 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,098 | train | mutant | 8,130 | 117 | 8,857 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I174L | V148L|I174L | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|174 | A | H|E | true | false | 1.818248 | 11.196161 | 17,282 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I92L | null | null | 4.4 | 1 | null | null | null | 0.79 | 0.83 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 986 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles. | 2,001 | 10.1021/bi011268l | 11705392 | Biochemistry;40;14004-11 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63814,"numValue":4.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63815,"numValue":1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63816,"numValue":0.83,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63817,"numValue":0.79,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7099 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,099 | train | mutant | 8,131 | 117 | 8,858 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|I174V | V148L|I174V | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|174 | A | H|E | true | false | 1.818248 | 11.196161 | 17,283 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:I92V | null | null | 5.5 | -0.1 | null | null | null | 0.89 | 0.92 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 986 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles. | 2,001 | 10.1021/bi011268l | 11705392 | Biochemistry;40;14004-11 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63819,"numValue":5.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63820,"numValue":-0.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63821,"numValue":0.92,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63822,"numValue":0.89,"references":[],"... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7100 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,100 | train | mutant | 8,132 | 117 | 8,859 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|V181I | V148I|V181I | 2 | 2 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|181 | A | H | true | false | 1.616692 | 9.875714 | 17,284 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:V99I | null | null | 4.7 | 0.7 | null | null | null | 0.8 | 0.88 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 986 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles. | 2,001 | 10.1021/bi011268l | 11705392 | Biochemistry;40;14004-11 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63824,"numValue":4.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63825,"numValue":0.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63826,"numValue":0.88,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63827,"numValue":0.8,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7101 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,101 | train | mutant | 8,133 | 117 | 8,860 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148I|V181L | V148I|V181L | 2 | 2 | 0 | 0 | 148 | V | I | 8 | CONSERVATION | 1STN | 140 | null | 148|181 | A | H | true | false | 1.616692 | 9.875714 | 17,285 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66I 1STN_A:V99L | null | null | 4.1 | 1.3 | null | null | null | 0.7 | 0.86 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 986 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles. | 2,001 | 10.1021/bi011268l | 11705392 | Biochemistry;40;14004-11 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63829,"numValue":4.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63830,"numValue":1.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63831,"numValue":0.86,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63832,"numValue":0.7,"references":[],"st... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7102 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,102 | train | mutant | 8,134 | 117 | 8,861 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|V181I | V148L|V181I | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|181 | A | H | true | false | 1.616692 | 9.875714 | 17,286 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:V99I | null | null | 4.8 | 0.6 | null | null | null | 0.89 | 0.81 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 986 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles. | 2,001 | 10.1021/bi011268l | 11705392 | Biochemistry;40;14004-11 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63834,"numValue":4.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63835,"numValue":0.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63836,"numValue":0.81,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63837,"numValue":0.89,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7103 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,103 | train | mutant | 8,135 | 117 | 8,862 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V148L|V181L | V148L|V181L | 2 | 2 | 0 | 0 | 148 | V | L | 8 | CONSERVATION | 1STN | 140 | null | 148|181 | A | H | true | false | 1.616692 | 9.875714 | 17,287 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V66L 1STN_A:V99L | null | null | 5.4 | 0 | null | null | null | 0.97 | 0.84 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 986 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles. | 2,001 | 10.1021/bi011268l | 11705392 | Biochemistry;40;14004-11 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63839,"numValue":5.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63840,"numValue":0.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63841,"numValue":0.84,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63842,"numValue":0.97,"references":[],"s... | [{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7951,"numValue":7.0,"position":181,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7104 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,104 | train | mutant | 1,284 | 117 | 1,434 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | E149F | E149F | 1 | 1 | 0 | 0 | 149 | E | F | 3 | CONSERVATION | 1STN | 140 | null | 149 | A | H | true | false | 89.564317 | 20.093333 | 2,448 | ProTherm | 7 | CD | Thermal | Phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:E67F | 46.1 | -6.6 | null | null | null | null | 80 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 225 | ARTICLE | Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation. | 2,007 | 10.1016/j.bpc.2006.10.014 | 17134819 | Biophys Chem;125;490-6 | 2 | Byrne Michael P|Stites Wesley E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"nu... | [{"datasets":[],"id":9002,"numValue":46.1,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":9003,"numValue":-6.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":9004,"numValue":80.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":9005,"numValue":null,"references":[],"... | [{"id":7919,"numValue":3.0,"position":149,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7105 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,105 | train | mutant | 1,284 | 117 | 1,434 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | E149F | E149F | 1 | 1 | 0 | 0 | 149 | E | F | 3 | CONSERVATION | 1STN | 140 | null | 149 | A | H | true | false | 89.564317 | 20.093333 | 2,543 | ProTherm | 7 | Fluorescence | Thermal | Phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:E67F | 48 | -5 | null | null | null | null | 68 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | PoPMuSiC-2.0_S2648.csv|STRUM_Q3421.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 225 | ARTICLE | Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation. | 2,007 | 10.1016/j.bpc.2006.10.014 | 17134819 | Biophys Chem;125;490-6 | 2 | Byrne Michael P|Stites Wesley E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"... | [{"datasets":["PoPMuSiC-2.0_S2648.csv","STRUM_Q3421.csv"],"id":9382,"numValue":48.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["PoPMuSiC-2.0_S2648.csv","STRUM_Q3421.csv"],"id":9383,"numValue":-5.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":9384,"numValue":68.0,"references":[],"strV... | [{"id":7919,"numValue":3.0,"position":149,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7106 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,106 | train | mutant | 1,284 | 117 | 1,434 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | E149F | E149F | 1 | 1 | 0 | 0 | 149 | E | F | 3 | CONSERVATION | 1STN | 140 | null | 149 | A | H | true | false | 89.564317 | 20.093333 | 13,348 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 600 mM | 1STN_A:E67F | null | null | 4.1 | 1.4 | null | null | null | 0.64 | 0.97 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 845 | ARTICLE | Stability effects of increasing the hydrophobicity of solvent-exposed side chains in staphylococcal nuclease. | 1,998 | 10.1021/bi9725069 | 9578580 | Biochemistry;37;6939-48 | 4 | Stites W E|Schwehm J M|Kristyanne E S|Biggers C C | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":49095,"numValue":4.1,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":49096,"numValue":1.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49097,"numValue":0.97,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":49098,"numValue":0.64,... | [{"id":7919,"numValue":3.0,"position":149,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7107 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,107 | train | mutant | 5,966 | 117 | 6,536 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | E149A | E149A | 1 | 1 | 0 | 0 | 149 | E | A | 3 | CONSERVATION | 1STN | 140 | null | 149 | A | H | true | false | 89.564317 | 20.093333 | 12,836 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:E67A | null | null | 4.6 | 1 | null | null | null | 0.64 | 1.02 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 827 | ARTICLE | Contributions of the ionizable amino acids to the stability of staphylococcal nuclease. | 1,996 | 10.1021/bi960171+ | 8639591 | Biochemistry;35;6443-9 | 3 | Shortle D|Garcia-Moreno B|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":46696,"numValue":4.6,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":46697,"numValue":1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46698,"numValue":1.02,"references":[],"strValue":nu... | [{"id":7919,"numValue":3.0,"position":149,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7108 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,108 | train | mutant | 5,967 | 117 | 6,537 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | E149G | E149G | 1 | 1 | 0 | 0 | 149 | E | G | 3 | CONSERVATION | 1STN | 140 | null | 149 | A | H | true | false | 89.564317 | 20.093333 | 12,837 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:E67G | null | null | 4.7 | 0.9 | null | null | null | 0.64 | 1.04 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 827 | ARTICLE | Contributions of the ionizable amino acids to the stability of staphylococcal nuclease. | 1,996 | 10.1021/bi960171+ | 8639591 | Biochemistry;35;6443-9 | 3 | Shortle D|Garcia-Moreno B|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":46701,"numValue":4.7,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":46702,"numValue":0.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46703,"numValue":1.04,"references":[],"strValue":nu... | [{"id":7919,"numValue":3.0,"position":149,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7109 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,109 | train | mutant | 6,055 | 117 | 6,640 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | E149Q | E149Q | 1 | 1 | 0 | 0 | 149 | E | Q | 3 | CONSERVATION | 1STN | 140 | null | 149 | A | H | true | false | 89.564317 | 20.093333 | 12,932 | ProTherm | 7 | Fluorescence | GdnHCl | sodium phosphate | 25 mM | 20 | sodium chloride | 100 mM | 1STN_A:E67Q | null | null | 4.9 | 0.5 | null | null | null | 0.72 | 6.8 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 828 | ARTICLE | Changes in stability upon charge reversal and neutralization substitution in staphylococcal nuclease are dominated by favorable electrostatic effects. | 2,003 | 10.1021/bi0266434 | 12549934 | Biochemistry;42;1118-28 | 5 | Stites Wesley E|Schwehm Jeffery M|Fitch Carolyn A|Dang Bao N|Garc?a-Moreno E Bertrand | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":47176,"numValue":4.9,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":47177,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":47178,"numValue":6.8,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":47179... | [{"id":7919,"numValue":3.0,"position":149,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7110 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,110 | train | mutant | 6,141 | 117 | 6,729 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | N150G | N150G | 1 | 1 | 0 | 0 | 150 | N | G | 4 | CONSERVATION | 1STN | 140 | null | 150 | A | T | true | false | 110.091032 | 25.15875 | 13,054 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:N68G | null | null | 5 | 0.5 | null | null | null | 0.77 | 0.96 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 833 | ARTICLE | Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state. | 1,992 | 10.1021/bi00140a005 | 1610820 | Biochemistry;31;5717-28 | 3 | Shortle D|Meeker A K|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":47739,"numValue":5.0,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":47740,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":47741,"numValue":0.96,"references... | [{"id":7920,"numValue":4.0,"position":150,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7111 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,111 | train | mutant | 6,142 | 117 | 6,730 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | N150A | N150A | 1 | 1 | 0 | 0 | 150 | N | A | 4 | CONSERVATION | 1STN | 140 | null | 150 | A | T | true | false | 110.091032 | 25.15875 | 13,055 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:N68A | null | null | 5 | 0.5 | null | null | null | 0.76 | 0.97 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 833 | ARTICLE | Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state. | 1,992 | 10.1021/bi00140a005 | 1610820 | Biochemistry;31;5717-28 | 3 | Shortle D|Meeker A K|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":47744,"numValue":5.0,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":47745,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":47746,"numValue":0.97,"references... | [{"id":7920,"numValue":4.0,"position":150,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7112 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,112 | train | mutant | 1,604 | 117 | 1,804 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | A151T | A151T | 1 | 1 | 0 | 0 | 151 | A | T | 6 | CONSERVATION | 1STN | 140 | null | 151 | A | L | true | false | 25.186647 | 15.826 | 3,007 | ProTherm | 7 | DSC | Thermal | Sodium phosphate | 20 mM | null | NaCl | 100 mM | 1STN_A:A69T | 40.5 | -13.7 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 268 | ARTICLE | Energetics of denaturation and m values of staphylococcal nuclease mutants. | 1,995 | 10.1021/bi00006a025 | 7849061 | Biochemistry;34;2034-41 | 2 | Privalov P L|Carra J H | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"IO... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10912,"numValue":40.5,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10913,"numValue":-13.7,"references":[],"strValue":null,"type":"DTM"},{"da... | [{"id":7921,"numValue":6.0,"position":151,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7113 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,113 | train | mutant | 1,604 | 117 | 1,804 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | A151T | A151T | 1 | 1 | 0 | 0 | 151 | A | T | 6 | CONSERVATION | 1STN | 140 | null | 151 | A | L | true | false | 25.186647 | 15.826 | 13,122 | ProTherm | 7 | Fluorescence | GdnHCl | Na3PO4 | 25 mM | 20 | NaCl | 0.1 M | 1STN_A:A69T | null | null | 2.9 | 2.7 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 837 | ARTICLE | Stability mutants of staphylococcal nuclease: large compensating enthalpy-entropy changes for the reversible denaturation reaction. | 1,988 | 10.1021/bi00413a027 | 3167015 | Biochemistry;27;4761-8 | 3 | Freire E|Shortle D|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Na3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":48050,"numValue":2.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48051,"numValue":2.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48052,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7921,"numValue":6.0,"position":151,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7114 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,114 | train | mutant | 1,604 | 117 | 1,804 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | A151T | A151T | 1 | 1 | 0 | 0 | 151 | A | T | 6 | CONSERVATION | 1STN | 140 | null | 151 | A | L | true | false | 25.186647 | 15.826 | 13,303 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:A69T | null | null | null | 2.63 | null | null | null | null | 1.13 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":["SAAFEC_S983.csv"],"id":48875,"numValue":2.63,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48876,"numValue":1.13,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48877,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7921,"numValue":6.0,"position":151,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7115 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,115 | train | mutant | 1,604 | 117 | 1,804 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | A151T | A151T | 1 | 1 | 0 | 0 | 151 | A | T | 6 | CONSERVATION | 1STN | 140 | null | 151 | A | L | true | false | 25.186647 | 15.826 | 13,315 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:A69T | null | null | 2.9 | 2.7 | null | null | null | 0.37 | 1.15 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 843 | ARTICLE | Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation. | 1,986 | 10.1002/prot.340010113 | 3449854 | Proteins;1;81-9 | 2 | Shortle D|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":48931,"numValue":2.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48932,"numValue":2.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48933,"numValue":1.15,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48934,"numValue":0.37,"references":[],"s... | [{"id":7921,"numValue":6.0,"position":151,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7116 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,116 | train | mutant | 1,604 | 117 | 1,804 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | A151T | A151T | 1 | 1 | 0 | 0 | 151 | A | T | 6 | CONSERVATION | 1STN | 140 | null | 151 | A | L | true | false | 25.186647 | 15.826 | 13,321 | ProTherm | 7 | Fluorescence | Urea | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:A69T | null | null | 3.2 | 3.9 | null | null | null | 1.22 | 1.11 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 843 | ARTICLE | Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation. | 1,986 | 10.1002/prot.340010113 | 3449854 | Proteins;1;81-9 | 2 | Shortle D|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","t... | [{"datasets":[],"id":48961,"numValue":3.2,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48962,"numValue":3.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48963,"numValue":1.11,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48964,"numValue":1.22,"references":[],"s... | [{"id":7921,"numValue":6.0,"position":151,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7117 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,117 | train | mutant | 6,095 | 117 | 6,683 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | A151G | A151G | 1 | 1 | 0 | 0 | 151 | A | G | 6 | CONSERVATION | 1STN | 140 | null | 151 | A | L | true | false | 25.186647 | 15.826 | 13,006 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:A69G | null | null | 3.5 | 2 | null | null | null | 0.48 | 1.05 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 833 | ARTICLE | Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state. | 1,992 | 10.1021/bi00140a005 | 1610820 | Biochemistry;31;5717-28 | 3 | Shortle D|Meeker A K|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":47501,"numValue":3.5,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":47502,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":47503,"numValue":1.05,"references":[],"strValue":nu... | [{"id":7921,"numValue":6.0,"position":151,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:7119 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,119 | train | mutant | 7,215 | 117 | 7,870 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | A151T|A172S | A151T|A172S | 2 | 2 | 0 | 0 | 151 | A | T | 6 | CONSERVATION | 1STN | 140 | null | 151|172 | A | L|E | true | false | 12.593324 | 11.821 | 15,524 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:A69T 1STN_A:A90S | null | null | null | 4.7 | null | null | null | null | 1.3 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":56986,"numValue":4.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":56987,"numValue":1.3,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":56988,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7921,"numValue":6.0,"position":151,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7942,"numValue":8.0,"position":172,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:7120 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 7,120 | train | mutant | 7,242 | 117 | 7,897 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | E157V|A151T | E157V|A151T | 2 | 2 | 0 | 0 | 157 | E | V | 6 | CONSERVATION | 1STN | 140 | null | 151|157 | A | L|E | true | false | 15.992276 | 14.353555 | 15,552 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:A69T 1STN_A:E75V | null | null | null | 4.35 | null | null | null | null | 1.03 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57070,"numValue":4.35,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57071,"numValue":1.03,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57072,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7921,"numValue":6.0,"position":151,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7927,"numValue":8.0,"position":157,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] |
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