LiteFold/InterPro · Datasets at Hugging Face

IPR013854

13,854

Transcription factor AP-2, C-terminal

TF_AP2_C

Domain

7,552

false

Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence 5'-GCCNNNGGC-3' and stimulate target gene transcription [ , ]. Five different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, g...

[]

0

[ "PFAM", "PRINTS" ]

[ "PF03299", "PR01748" ]

[ "TF_AP-2", "AP2TNSCPFCT" ]

[ 7552, 6734 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-8864260", "R-BTA-8866904", "R-BTA-8866907", "R-BTA-8869496", "R-BTA-9834899", "R-CEL-3232118", "R-CEL-8866904", "R-CEL-8866907", "R-CEL-9834899", "R-CFA-8866904", "R-CFA-8866907", "R-CFA-9834899", "R-DRE-8866907", "R-HSA-3232118", "R-HSA-8864260", "R-HSA-8866904", "R-HSA-88669...

[ "REACTOME:R-BTA-8864260", "REACTOME:R-BTA-8866904", "REACTOME:R-BTA-8866907", "REACTOME:R-BTA-8869496", "REACTOME:R-BTA-9834899", "REACTOME:R-CEL-3232118", "REACTOME:R-CEL-8866904", "REACTOME:R-CEL-8866907", "REACTOME:R-CEL-9834899", "REACTOME:R-CFA-8866904", "REACTOME:R-CFA-8866907", "REACTOM...

38

[ "8j0k", "8j0l", "8j0q", "8j0r" ]

4

[ "PUB00010264", "PUB00010265", "PUB00010332", "PUB00010369", "PUB00010381", "PUB00099637", "PUB00099638" ]

[ "1998122", "2010091", "9632718", "10864206", "11137286", "27176626", "11694877" ]

[ "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins.", "Analysis of the DNA-binding and activation properties of the human transcription factor AP-2.", "Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human...

[ 1991, 1991, 1998, 2000, 2000, 2016, 2001 ]

7

[]

0

null

[ "Clostridia", "Eukaryota" ]

[ 2, 7550 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 52, 6, 13, 19, 24 ]

6

true

Domain

Transcription factor AP-2, C-terminal

TF_AP2_C

4

IPR013855

13,855

Cdc37, N-terminal domain

Cdc37_N_dom

Domain

3,714

false

Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This entry corresponds to the N-terminal kinase binding domain of these proteins [ ]. It is found N-terminal to a Hsp90 chaperone (heat shock protein 90) binding domain ( ). Expression of a construct consisting of only the ...

[ "GO:0019901" ]

[ "protein kinase binding" ]

[ "molecular_function" ]

1

[ "PFAM", "SMART" ]

[ "PF03234", "SM01071" ]

[ "CDC37_N", "CDC37_N" ]

[ 3434, 3643 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1227986", "R-BTA-5675482", "R-BTA-8863795", "R-BTA-9013418", "R-BTA-9652282", "R-CEL-114608", "R-CEL-1227986", "R-CEL-8863795", "R-CEL-9652282", "R-DME-114608", "R-DME-1227986", "R-DME-8863795", "R-DME-9013418", "R-DME-9652282", "R-HSA-1227986", "R-HSA-1236382", "R-HSA-5637810...

[ "REACTOME:R-BTA-1227986", "REACTOME:R-BTA-5675482", "REACTOME:R-BTA-8863795", "REACTOME:R-BTA-9013418", "REACTOME:R-BTA-9652282", "REACTOME:R-CEL-114608", "REACTOME:R-CEL-1227986", "REACTOME:R-CEL-8863795", "REACTOME:R-CEL-9652282", "REACTOME:R-DME-114608", "REACTOME:R-DME-1227986", "REACTOME:...

46

[ "2nca", "5fwk", "5fwl", "5fwm", "5fwp", "7z37", "7z38", "7zr0", "7zr5", "7zr6", "8fx4", "8gae", "8gft", "8u1l", "9kqn" ]

15

[ "PUB00033273" ]

[ "16098195" ]

[ "Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 3713, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 1, 3, 5, 2, 1, 6, 1, 1 ]

9

true

Domain

Cdc37, N-terminal domain

Cdc37_N_dom

6

IPR013856

13,856

Peptidase M4 domain

Peptidase_M4_domain

Domain

15,539

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[ "GO:0004222" ]

[ "metalloendopeptidase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF01447" ]

[ "Peptidase_M4" ]

[ 15539 ]

1

[ "EC" ]

[ "3.4.24" ]

[ "EC:3.4.24" ]

1

[ "1bqb", "1esp", "1ezm", "1fj3", "1fjo", "1fjq", "1fjt", "1fju", "1fjv", "1fjw", "1gxw", "1hyt", "1kei", "1kjo", "1kjp", "1kkk", "1kl6", "1kr6", "1kro", "1ks7", "1kto", "1l3f", "1lna", "1lnb", "1lnc", "1lnd", "1lne", "1lnf", "1npc", "1os0", "1pe5", "1pe7"...

263

[ "PUB00003579" ]

[ "7674922" ]

[ "Evolutionary families of metallopeptidases." ]

[ 1995 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 28, 14782, 690, 39 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Peptidase M4 domain

Peptidase_M4_domain

4

IPR013857

13,857

NADH:ubiquinone oxidoreductase intermediate-associated protein 30

NADH-UbQ_OxRdtase-assoc_prot30

Domain

9,616

false

Mitochondrial complex I intermediate-associated protein 30 (CIA30) is present in human and mouse, and also in Schizosaccharomyces pombe (Fission yeast) which does not contain the NADH dehydrogenase component of complex I, or many of the other essential subunits. This means it is not directly involved in oxidative phosp...

[]

0

[ "PFAM" ]

[ "PF08547" ]

[ "CIA30" ]

[ 9616 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-6799198", "R-HSA-6799198", "R-MMU-6799198" ]

[ "REACTOME:R-DME-6799198", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-6799198" ]

3

[ "7zkp", "7zkq" ]

2

[ "PUB00019330", "PUB00033275", "PUB00088969" ]

[ "1518044", "11935339", "23226344" ]

[ "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction.", "CIA30 complex I assembly factor: a candidate for human complex I deficiency?", "Expression of yeast NDI1 rescues a Drosophil...

[ 1992, 2002, 2012 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcina lacustris Z-7289", "metagenomes" ]

[ 2020, 7565, 1, 30 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 24, 1, 4, 1, 6, 3, 1, 14, 2, 1, 18 ]

11

true

Domain

NADH:ubiquinone oxidoreductase intermediate-associated protein 30

NADH-UbQ_OxRdtase-assoc_prot30

8

IPR013858

13,858

Peptidase M10 serralysin, C-terminal

Peptidase_M10B_C

Domain

6,206

false

Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N-terminal, while this domain at the C-terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the hemolysin-type calci...

[ "GO:0005509", "GO:0005615" ]

[ "calcium ion binding", "extracellular space" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08548" ]

[ "Peptidase_M10_C" ]

[ 6206 ]

1

[ "EC" ]

[ "3.4.24.40" ]

[ "EC:3.4.24.40" ]

1

[ "1af0", "1akl", "1g9k", "1go7", "1go8", "1h71", "1jiw", "1k7g", "1k7i", "1k7q", "1kap", "1o0q", "1o0t", "1om6", "1om7", "1om8", "1omj", "1sat", "1smp", "1srp", "2ml1", "2ml2", "3hb2", "3hbu", "3hbv", "3hda", "3u1r", "3vi1", "4i35", "5d7w", "6ixx" ]

31

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6178, 10, 18 ]

3

[]

0

true

Domain

Peptidase M10 serralysin, C-terminal

Peptidase_M10B_C

6

IPR013859

13,859

SWI/SNF and RSC complexes subunit Ssr4, N-terminal

Ssr4_N

Domain

1,266

false

This is the N-terminal domain of the SWI/SNF and RSC complexes subunit Ssr4 from S. pombe, a member of the chromatin structure remodeling complex (RSC) and the SWI/SNF complex [ , ]. RSC is involved in transcription regulation and nucleosome positioning which controls, particularly, membrane and organelle development g...

[ "GO:0006338" ]

[ "chromatin remodeling" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08549" ]

[ "SWI-SNF_Ssr4_N" ]

[ 1266 ]

1

[]

0

[ "7k7v", "7k7w", "7k82" ]

3

[ "PUB00066307", "PUB00101211" ]

[ "18622392", "33263569" ]

[ "Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.", "The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein." ]

[ 2008, 2020 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1266 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Domain

SWI/SNF and RSC complexes subunit Ssr4, N-terminal

Ssr4_N

9

IPR013860

13,860

Nitrogen regulatory protein areA, GATA-like domain

AreA_GATA

Domain

6,395

false

This entry represents fungal proteins containing GATA domains, including nitrogen regulatory protein areA, a transcription activator that binds the consensus DNA element 5'-CGATAG-3' and mediates nitrogen metabolite repression [ ]. The entry also contains that is thought to be a negative regulator of RAS-cAMP pathway i...

[]

0

[ "PFAM" ]

[ "PF08550" ]

[ "GATA_AreA" ]

[ 6395 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-SCE-9018519", "R-SPO-9018519" ]

[ "REACTOME:R-SCE-9018519", "REACTOME:R-SPO-9018519" ]

2

[]

0

[ "PUB00089490" ]

[ "1970293" ]

[ "The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans. Mutations affecting specificity of gene activation alter a loop residue of a putative zinc finger." ]

[ 1990 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadota" ]

[ 6393, 2 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 1, 4, 3, 2 ]

5

true

Domain

Nitrogen regulatory protein areA, GATA-like domain

AreA_GATA

7

IPR013861

13,861

TMEM115/Pdh1/Rbl19

Family

4,993

false

This entry represents a group of eukaryotic transmembrane proteins, including TMEM115 from animals, Pdh1 from fission yeasts and Rbl19 from Arabisopsis. Human TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport [ ]. Budding yeast TMEM115 homologue, YOL107W, has been shown to lo...

[ "GO:0006890", "GO:0016020" ]

[ "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF08551", "PTHR13377" ]

[ "DUF1751", "" ]

[ 4432, 4598 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6807878", "R-HSA-6807878", "R-MMU-6807878" ]

[ "REACTOME:R-BTA-6807878", "REACTOME:R-HSA-6807878", "REACTOME:R-MMU-6807878" ]

3

[]

0

[ "PUB00016470", "PUB00075338" ]

[ "14562095", "24806965" ]

[ "Global analysis of protein localization in budding yeast.", "TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport." ]

[ 2003, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "mine drainage metagenome" ]

[ 75, 4917, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 2, 4, 1, 3, 3, 2, 9, 2, 1, 1, 29 ]

12

true

Family

TMEM115/Pdh1/Rbl19

9

IPR013862

13,862

Inositolphosphorylceramide synthase subunit Kei1

Kei1

Family

1,602

false

Kei1 is a subunit of Saccharomyces cerevisiae inositol phosphorylceramide (IPC) synthase [ ]. It is localised to the Golgi and is cleaved by the late Golgi processing endopeptidase Kex2 [ ]. Kei1 is essential for both the activity and the Golgi localization of IPC synthase [ ].

[ "GO:0070917", "GO:0006673" ]

[ "inositol phosphoceramide synthase regulator activity", "inositol phosphoceramide metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF08552", "PTHR28077" ]

[ "Kei1", "" ]

[ 1602, 1545 ]

2

[ "GP" ]

[ "GenProp1423" ]

[ "GP:GenProp1423" ]

1

[ "9ivc" ]

1

[ "PUB00092487" ]

[ "19726565" ]

[ "Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization." ]

[ 2009 ]

1

[]

0

null

[ "Burkholderia cenocepacia", "Eukaryota" ]

[ 1, 1601 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Inositolphosphorylceramide synthase subunit Kei1

Kei1

7

IPR013865

13,865

Protein FAM32A

FAM32A

Family

4,499

false

FAM32A, also known as OTAG12, has been linked to ovarian tumour in humans and mice [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08555", "PTHR13282" ]

[ "FAM32A", "" ]

[ 3857, 4086 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-72163", "R-DRE-72163", "R-HSA-72163", "R-MMU-72163", "R-RNO-72163" ]

[ "REACTOME:R-BTA-72163", "REACTOME:R-DRE-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163" ]

5

[ "6qdv", "7w5a", "7w5b", "8c6j", "9fmd" ]

5

[ "PUB00092488" ]

[ "21339736" ]

[ "Anti-proliferative and pro-apoptotic actions of a novel human and mouse ovarian tumor-associated gene OTAG-12: downregulation, alternative splicing and drug sensitization." ]

[ 2011 ]

1

[]

0

null

[ "Eukaryota", "Streptomyces montanus", "human gut metagenome" ]

[ 4497, 1, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 3, 2, 1, 1, 5, 1, 1, 4, 5, 1, 67 ]

11

true

Family

Protein FAM32A

FAM32A

2

IPR013866

13,866

Sphingolipid delta4-desaturase, N-terminal

Sphingolipid_d4-desaturase_N

Domain

5,217

false

This small domain appears to be specific to sphingolipid delta 4-desaturase. Sphingolipids are important membrane signalling molecules involved in many different cellular functions in eukaryotes. Sphingolipid delta 4-desaturase catalyses the formation of (E)-sphing-4-enine [ ]. Some proteins with this domain have bifun...

[]

0

[ "PFAM", "SMART" ]

[ "PF08557", "SM01269" ]

[ "Lipid_DES", "Lipid_DES" ]

[ 5201, 5037 ]

2

[ "EC", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.19.17", "GenProp1665", "GenProp1671", "PWY-5129", "R-BTA-1660661", "R-BTA-6798695", "R-CEL-1660661", "R-CEL-6798695", "R-DME-1660661", "R-DME-6798695", "R-GGA-1660661", "R-GGA-433584", "R-GGA-6798695", "R-HSA-1660661", "R-HSA-6798695", "R-MMU-1660661", "R-MMU-6798695", "R-RNO...

[ "EC:1.14.19.17", "GP:GenProp1665", "GP:GenProp1671", "METACYC:PWY-5129", "REACTOME:R-BTA-1660661", "REACTOME:R-BTA-6798695", "REACTOME:R-CEL-1660661", "REACTOME:R-CEL-6798695", "REACTOME:R-DME-1660661", "REACTOME:R-DME-6798695", "REACTOME:R-GGA-1660661", "REACTOME:R-GGA-433584", "REACTOME:R-...

23

[]

0

[ "PUB00014620" ]

[ "11937514" ]

[ "Identification and characterization of a sphingolipid delta 4-desaturase family." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Emiliania huxleyi virus 86 (isolate United Kingdom/English Channel/1999)", "Eukaryota", "metagenomes" ]

[ 300, 1, 4913, 3 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 5, 2, 2, 1, 3, 4, 1, 1, 6, 1, 10 ]

11

true

Domain

Sphingolipid delta4-desaturase, N-terminal

Sphingolipid_d4-desaturase_N

5

IPR013867

13,867

Telomere repeat-binding factor, dimerisation domain

Telomere_rpt-bd_fac_dimer_dom

Domain

2,967

false

Telomeres function to shield chromosome ends from degradation and end-to-end fusions, as well as preventing the activation of DNA damage checkpoints. Telomeric repeat binding factor (TRF) proteins TRF1 and TRF2 are major components of vertebrate telomeres required for regulation of telomere stability. TRF1 and TRF2 bin...

[ "GO:0042162", "GO:0042803" ]

[ "telomeric DNA binding", "protein homodimerization activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM" ]

[ "PF08558" ]

[ "TRF" ]

[ 2967 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-GGA-418124", "R-HSA-110328", "R-HSA-110329", "R-HSA-110330", "R-HSA-110331", "R-HSA-1221632", "R-HSA-171306", "R-HSA-171319", "R-HSA-174411", "R-HSA-174414", "R-HSA-174417", "R-HSA-174430", "R-HSA-174437", "R-HSA-2559586", "R-HSA-9670095", "R-MMU-110330", "R-MMU-110331", "R-MMU-...

[ "REACTOME:R-GGA-418124", "REACTOME:R-HSA-110328", "REACTOME:R-HSA-110329", "REACTOME:R-HSA-110330", "REACTOME:R-HSA-110331", "REACTOME:R-HSA-1221632", "REACTOME:R-HSA-171306", "REACTOME:R-HSA-171319", "REACTOME:R-HSA-174411", "REACTOME:R-HSA-174414", "REACTOME:R-HSA-174417", "REACTOME:R-HSA-17...

25

[ "1h6o", "1h6p", "3bqo", "3bu8", "3bua", "3l82", "4m7c", "4rqi", "4zmi", "5wir", "5wqd", "5xup", "6j67", "6k5s", "7c5d", "8ox1", "8w8g", "8x6e", "9q9m" ]

19

[ "PUB00013264", "PUB00033335", "PUB00033336" ]

[ "11545737", "15316005", "9034194" ]

[ "Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.", "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.", "Regulation of telomere length and function by a Myb-domain protein in fission yeast." ]

[ 2001, 2004, 1997 ]

3

[]

0

null

[ "Opisthokonta" ]

[ 2967 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 15, 15, 7, 1, 8, 1, 2 ]

7

true

Domain

Telomere repeat-binding factor, dimerisation domain

Telomere_rpt-bd_fac_dimer_dom

4

IPR013869

13,869

Protein of unknown function DUF1757

DUF1757

Family

765

false

This entry shows proteins that are about 150 amino acids in length and have no known function.

[]

0

[ "PFAM" ]

[ "PF08560" ]

[ "DUF1757" ]

[ 765 ]

1

[]

0

[ "8iuf" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 765 ]

1

[ "Caenorhabditis elegans" ]

[ 4 ]

1

true

Family

Protein of unknown function DUF1757

DUF1757

1

IPR013870

13,870

Large ribosomal subunit protein mL54

Ribosomal_mL54

Family

3,964

false

This entry represents the large ribosomal subunit protein mL54 from eukaryotes [ ], previously known as MRPL37 in yeast [ ] and MRPL54 in human [ ]. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08561", "PTHR28595" ]

[ "Ribosomal_L37", "" ]

[ 3938, 3800 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-5389840", "R-DRE-5419276", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-DRE-5389840", "REACTOME:R-DRE-5419276", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383" ]

9

[ "3j9m", "4v1a", "5aj4", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu3", "6vlz", "6vmi", "6ydp", "6ydw", "6ywe", "6yws", "6ywv", "6ywx", "6ywy", "6z1p", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g", "7a5h", "7a5i"...

92

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00033319", "PUB00080279", "PUB00089008" ]

[ "11297922", "11290319", "11114498", "15543521", "24524803", "25838379" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Analysis of the meiotic role of the mitochondrial ribosomal proteins Mrps17 and Mrpl37 in Saccharomyces cerevisiae.", "A new system for naming ribosomal prote...

[ 2001, 2001, 2000, 2004, 2014, 2015 ]

6

[]

0

null

[ "Eukaryota" ]

[ 3964 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 1, 2, 1, 1, 1, 2, 2, 1, 1, 6 ]

12

true

Family

Large ribosomal subunit protein mL54

Ribosomal_mL54

3

IPR013871

13,871

Cysteine-rich secretory protein

Cysteine_rich_secretory

Domain

2,029

false

This entry is found on Crisp proteins which contain and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling [ ]. It contains 10 conserved cysteines which are all involved in disulphide bonds and is...

[]

0

[ "PFAM" ]

[ "PF08562" ]

[ "Crisp" ]

[ 2029 ]

1

[ "REACTOME" ]

[ "R-HSA-6798695" ]

[ "REACTOME:R-HSA-6798695" ]

1

[ "1rc9", "1wvr", "1xta", "1xx5", "2a05", "2cq7", "2dda", "2ddb", "2epf", "2giz", "3mz8", "6imf" ]

12

[ "PUB00033277" ]

[ "16339766" ]

[ "The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling." ]

[ 2006 ]

1

[]

0

null

[ "Bilateria", "Escherichia coli" ]

[ 2028, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 8, 8, 10 ]

4

true

Domain

Cysteine-rich secretory protein

Cysteine_rich_secretory

6

IPR013873

13,873

Cdc37, C-terminal

Cdc37_C

Domain

3,674

false

Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This entry corresponds to the C-terminal domain whose function is unclear. It is found C-terminal to the Hsp90 chaperone (heat shock protein 90) binding domain ( ) and the N-terminal kinase binding domain of Cdc37 ( ) [ ].

[]

0

[ "PFAM", "SMART" ]

[ "PF08564", "SM01069" ]

[ "CDC37_C", "CDC37_C" ]

[ 3605, 3653 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1227986", "R-BTA-5675482", "R-BTA-8863795", "R-BTA-9013418", "R-BTA-9652282", "R-CEL-114608", "R-CEL-1227986", "R-CEL-8863795", "R-CEL-9652282", "R-DME-114608", "R-DME-1227986", "R-DME-8863795", "R-DME-9013418", "R-DME-9652282", "R-DRE-114608", "R-HSA-1227986", "R-HSA-1236382"...

[ "REACTOME:R-BTA-1227986", "REACTOME:R-BTA-5675482", "REACTOME:R-BTA-8863795", "REACTOME:R-BTA-9013418", "REACTOME:R-BTA-9652282", "REACTOME:R-CEL-114608", "REACTOME:R-CEL-1227986", "REACTOME:R-CEL-8863795", "REACTOME:R-CEL-9652282", "REACTOME:R-DME-114608", "REACTOME:R-DME-1227986", "REACTOME:...

47

[ "1us7", "2n5x", "5fwk", "5fwl", "5fwm", "5fwp", "7z37", "7z38", "7zr0", "7zr5", "7zr6", "8fx4", "8gae", "8gft", "8u1l", "9kqn" ]

16

[ "PUB00033273" ]

[ "16098195" ]

[ "Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonas aeruginosa", "Pseudomonas phage phiCTX", "bird metagenome" ]

[ 3671, 1, 1, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 3, 3, 6, 1, 1, 8, 1, 1 ]

9

true

Domain

Cdc37, C-terminal

Cdc37_C

2

IPR013874

13,874

Cdc37, Hsp90 binding

Cdc37_Hsp90-bd

Domain

4,873

false

Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This entry corresponds to the Hsp90 chaperone (heat shock protein 90) binding domain of Cdc37 [ ]. It is found between the N-terminal Cdc37 domain ( ), which is predominantly involved in kinase binding, and the C-terminal d...

[]

0

[ "PFAM", "SMART" ]

[ "PF08565", "SM01070" ]

[ "CDC37_M", "CDC37_M" ]

[ 4737, 4824 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-114608", "R-BTA-1227986", "R-BTA-5675482", "R-BTA-8863795", "R-BTA-9013418", "R-BTA-9652282", "R-CEL-114608", "R-CEL-1227986", "R-CEL-8863795", "R-CEL-9652282", "R-DME-114608", "R-DME-1227986", "R-DME-8863795", "R-DME-9013418", "R-DME-9652282", "R-DRE-114608", "R-HSA-114608", ...

[ "REACTOME:R-BTA-114608", "REACTOME:R-BTA-1227986", "REACTOME:R-BTA-5675482", "REACTOME:R-BTA-8863795", "REACTOME:R-BTA-9013418", "REACTOME:R-BTA-9652282", "REACTOME:R-CEL-114608", "REACTOME:R-CEL-1227986", "REACTOME:R-CEL-8863795", "REACTOME:R-CEL-9652282", "REACTOME:R-DME-114608", "REACTOME:R...

52

[ "1us7", "2k5b", "2w0g", "5fwk", "5fwl", "5fwm", "5fwp", "7z37", "7z38", "7zr0", "7zr5", "7zr6", "8fx4", "8gae", "8gft", "8u1l", "9kqn" ]

17

[ "PUB00033273" ]

[ "16098195" ]

[ "Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 4872, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 3, 3, 3, 6, 5, 1, 19, 1, 1 ]

9

true

Domain

Cdc37, Hsp90 binding

Cdc37_Hsp90-bd

3

IPR013875

13,875

Mitochondrial import protein Pam17

Pam17

Family

1,709

false

The presequence translocase-associated motor (PAM) drives the completion of preprotein translocation into the mitochondrial matrix. The Pam17 subunit is required for formation of a stable complex between cochaperones Pam16 and Pam18 and promotes the association of Pam16-Pam18 with the presequence translocase [ ]. Mitoc...

[ "GO:0001405" ]

[ "PAM complex, Tim23 associated import motor" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF08566", "PTHR28021" ]

[ "Pam17", "" ]

[ 1709, 1693 ]

2

[]

0

[]

0

[ "PUB00033306" ]

[ "16107694" ]

[ "Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor." ]

[ 2005 ]

1

[]

0

null

[ "Opisthokonta", "marine sediment metagenome" ]

[ 1708, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Mitochondrial import protein Pam17

Pam17

8

IPR013876

13,876

TFIIH p62 subunit, N-terminal

TFIIH_BTF_p62_N

Domain

3,907

false

The N-terminal region of the TFIIH basal transcription factor complex p62 subunit (BTF2-p62) forms an interaction with the 3' endonuclease XPG, which is essential for activity. The 3' endonuclease XPG is a major component of the nucleotide excision repair machinery. The structure of the N-terminal region reveals that i...

[]

0

[ "PFAM" ]

[ "PF08567" ]

[ "PH_TFIIH" ]

[ 3907 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DDI-113418", "R-DDI-5696395", "R-DDI-674695", "R-DDI-6781823", "R-DDI-6782135", "R-DDI-6782210", "R-DDI-6796648", "R-DDI-72086", "R-DDI-73772", "R-DDI-73776", "R-DDI-73779", "R-DDI-75953", "R-DDI-76042", "R-DDI-77075", "R-DME-112382", "R-DME-113418", "R-DME-5696395", "R-DME-5696...

[ "REACTOME:R-DDI-113418", "REACTOME:R-DDI-5696395", "REACTOME:R-DDI-674695", "REACTOME:R-DDI-6781823", "REACTOME:R-DDI-6782135", "REACTOME:R-DDI-6782210", "REACTOME:R-DDI-6796648", "REACTOME:R-DDI-72086", "REACTOME:R-DDI-73772", "REACTOME:R-DDI-73776", "REACTOME:R-DDI-73779", "REACTOME:R-DDI-75...

107

[ "1pfj", "1y5o", "2gs0", "2k2u", "2l2i", "2lox", "2m14", "2mkr", "2n0y", "2n23", "2rnr", "2ruk", "2rvb", "5gow", "5oqj", "5oqm", "5urn", "5xv8", "6gym", "6nmi", "6o9l", "6o9m", "7ad8", "7bmu", "7bmv", "7bmw", "7bmx", "7bmy", "7bmz", "7bul", "7dti", "7egb"...

85

[ "PUB00029837", "PUB00033333" ]

[ "15195146", "15909982" ]

[ "TFIIH contains a PH domain involved in DNA nucleotide excision repair.", "NMR structure of the amino-terminal domain from the Tfb1 subunit of TFIIH and characterization of its phosphoinositide and VP16 binding sites." ]

[ 2004, 2005 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3907 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizo...

[ 10, 1, 1, 2, 6, 6, 1, 3, 1, 1 ]

10

true

Domain

TFIIH p62 subunit, N-terminal

TFIIH_BTF_p62_N

1

IPR013877

13,877

YAP-binding/ALF4/Glomulin

YAP-bd/ALF4/Glomulin

Family

4,029

false

This entry contains a number of protein families with apparently unrelated functions. The yeast YAP binding proteins are stress response and redox homeostasis proteins, induced by hydrogen peroxide or induced in response to alkylating agent methyl methanesulphonate (MMS) [ , ]. Aberrant root formation protein 4 (ALF4) ...

[]

0

[ "PFAM" ]

[ "PF08568" ]

[ "Kinetochor_Ybp2" ]

[ 4029 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-983168", "R-MMU-983168" ]

[ "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168" ]

2

[ "4f52" ]

1

[ "PUB00044263", "PUB00053725", "PUB00053726", "PUB00053727", "PUB00053728" ]

[ "11571281", "12743123", "9990050", "14731255", "12604780" ]

[ "Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor.", "Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor.", "Global response of Saccharomyces cerevisiae to an alkylating agent.", "Arabidopsis ALF4 encodes a nuclear-localized protein required...

[ 2001, 2003, 1999, 2004, 2003 ]

5

[]

[ "IPR019516", "IPR040347" ]

0

2

0

[ "Eukaryota" ]

[ 4029 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 11, 7, 1, 4, 5, 1, 3, 4, 2, 1, 12 ]

11

true

Family

YAP-binding/ALF4/Glomulin

YAP-bd/ALF4/Glomulin

9

IPR013878

13,878

Mo25-like

Mo25

Family

7,947

false

Mo25-like proteins are involved in both polarised growth and cytokinesis. In fission yeast Mo25 is localised alternately to the spindle pole body and to the site of cell division in a cell cycle dependent manner [ , ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08569", "PTHR10182" ]

[ "Mo25", "" ]

[ 7938, 7854 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-380972", "R-BTA-6798695", "R-CEL-6798695", "R-DME-6798695", "R-HSA-380972", "R-HSA-6798695", "R-MMU-380972", "R-MMU-6798695", "R-SCE-6798695", "R-SPO-6798695" ]

[ "REACTOME:R-BTA-380972", "REACTOME:R-BTA-6798695", "REACTOME:R-CEL-6798695", "REACTOME:R-DME-6798695", "REACTOME:R-HSA-380972", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-380972", "REACTOME:R-MMU-6798695", "REACTOME:R-SCE-6798695", "REACTOME:R-SPO-6798695" ]

10

[ "1upk", "1upl", "2wtk", "3gni", "3zhp", "4fza", "4fzd", "4fzf", "4kzg", "4nzw", "4o27", "8vsu" ]

12

[ "PUB00033297", "PUB00033298" ]

[ "16325501", "16096637" ]

[ "The fission yeast MO25 protein functions in polar growth and cell separation.", "Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis." ]

[ 2005, 2005 ]

2

[]

0

null

[ "Eukaryota" ]

[ 7947 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 20, 4, 5, 2, 8, 5, 1, 9, 11, 1, 1, 57 ]

12

true

Family

Mo25-like

Mo25

8

IPR013879

13,879

Protein of unknown function DUF1761

DUF1761

Family

4,464

false

This entry represents a family of conserved proteins with unknown function.

[]

0

[ "PFAM" ]

[ "PF08570" ]

[ "DUF1761" ]

[ 4464 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5, 3223, 1175, 61 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Family

Protein of unknown function DUF1761

DUF1761

6

IPR013880

13,880

Yos1-like

Yos1

Family

3,870

false

In yeast, Yos1 is a subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08571", "PTHR15858" ]

[ "Yos1", "" ]

[ 3870, 3624 ]

2

[]

0

[]

0

[ "PUB00033378", "PUB00087174" ]

[ "15659647", "28915629" ]

[ "Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex.", "IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation." ]

[ 2005, 2017 ]

2

[]

0

null

[ "Eukaryota", "Vibrio vulnificus" ]

[ 3869, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 1, 3, 2, 1, 8, 6, 1, 1, 4 ]

12

true

Family

Yos1-like

Yos1

5

IPR013881

13,881

Pre-mRNA-splicing factor 3 domain

Pre-mRNA_splic_Prp3_dom

Domain

5,120

false

This entry represents a domain that is located centrally in mammal U4/U6 small nuclear ribonucleoprotein Prp3 and Protein RDM16 from Arabidopsis thaliana and towards the N-terminal end in Prp3 from yeast. Pre-mRNA processing factor 3 (PRP3) is a U4/U6-associated splicing factor. It plays a key role in the recognition o...

[]

0

[ "PFAM" ]

[ "PF08572" ]

[ "PRP3" ]

[ 5120 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163" ]

2

[ "3jcm", "3jcr", "5gan", "5gap", "5nrl", "5o9z", "5zwm", "5zwo", "6ah0", "6ahd", "6qw6", "6qx9", "8h6e", "8h6j", "8h6k", "8h6l", "8q7n", "8qo9", "8qoz", "8qp8", "8qp9", "8qpa", "8qpb", "8qpe", "8qxd", "8qzs", "8r08", "8r09", "8r0a", "8r0b", "8rm5", "8y6o"...

32

[ "PUB00033315", "PUB00062917", "PUB00062918", "PUB00083217", "PUB00100667" ]

[ "11773002", "12714658", "17932117", "24068953", "26829225" ]

[ "Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa.", "Mutations in the pre-mRNA splicing-factor genes PRPF3, PRPF8, and PRPF31 in Spanish families with autosomal dominant retinitis pigmentosa.", "Mutation in the splicing factor Hprp3p li...

[ 2002, 2003, 2008, 2013, 2016 ]

5

[]

0

null

[ "Eukaryota" ]

[ 5120 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 1, 2, 5, 2, 1, 4, 4, 1, 1, 12 ]

12

true

Domain

Pre-mRNA-splicing factor 3 domain

Pre-mRNA_splic_Prp3_dom

5

IPR013882

13,882

DNA endonuclease activator Ctp1, C-terminal

Ctp1_C

Domain

3,538

false

This entry represents the C-terminal domain of the fission yeast Ctip (Ctp1) protein. Proteins containing this domain include DNA endonuclease RBBP8 (also known as CtBP-interacting protein, CtIP) from animals, protein gamma response 1 (GR1) from Arabidopsis and SAE2 from S. cerevisiae [ , ]. SAE2 is a protein involved ...

[ "GO:0006281" ]

[ "DNA repair" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08573" ]

[ "SAE2" ]

[ 3538 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DRE-5693607", "R-HSA-5685938", "R-HSA-5685939", "R-HSA-5685942", "R-HSA-5693554", "R-HSA-5693568", "R-HSA-5693579", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6804756", "R-HSA-69473", "R-HSA-8953750", "R-HSA-912446", "R-HSA-9701192", "R-HSA-9704331", "R-HSA-9704646", "R-HSA-9709570"...

[ "REACTOME:R-DRE-5693607", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5685939", "REACTOME:R-HSA-5685942", "REACTOME:R-HSA-5693554", "REACTOME:R-HSA-5693568", "REACTOME:R-HSA-5693579", "REACTOME:R-HSA-5693607", "REACTOME:R-HSA-5693616", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-69473", "REACTOME:...

36

[]

0

[ "PUB00033325", "PUB00033326", "PUB00044219", "PUB00055958", "PUB00072956", "PUB00079215", "PUB00098332" ]

[ "16374511", "16162495", "17936710", "18042458", "17965729", "11023598", "33836577" ]

[ "The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling.", "The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.", "Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break r...

[ 2006, 2005, 2007, 2007, 2007, 2000, 2021 ]

7

[]

0

null

[ "Eukaryota" ]

[ 3538 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 5, 3, 3, 2, 1, 3, 4, 1, 1, 6 ]

10

true

Domain

DNA endonuclease activator Ctp1, C-terminal

Ctp1_C

1

IPR013883

13,883

Transcription factor Iwr1 domain

TF_Iwr1_dom

Domain

3,721

false

Iwr1 is involved in transcription from polymerase II promoters; it interacts with with most of the polymerase II subunits [ ]. Deletion of this protein results in hypersensitivity to the K1 killer toxin [ ].

[]

0

[ "PFAM" ]

[ "PF08574" ]

[ "Iwr1" ]

[ 3721 ]

1

[]

0

[]

0

[ "PUB00033286", "PUB00054162", "PUB00090608" ]

[ "12663529", "19679657", "20010803" ]

[ "A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin.", "The yeast RNA polymerase II-associated factor Iwr1p is involved in the basal and regulated transcription of specific genes.", "RNA-directed DNA methylation and plant development require an IWR1-type transcriptio...

[ 2003, 2009, 2010 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3721 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizo...

[ 4, 1, 2, 2, 2, 1, 1, 3, 1, 1 ]

10

true

Domain

Transcription factor Iwr1 domain

TF_Iwr1_dom

8

IPR013885

13,885

Protein of unknown function DUF1764, eukaryotic

DUF1764_euk

Family

1,388

false

This entry consists of eukaryotic proteins of unknown function, including many hypothetical proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08576", "PTHR34066" ]

[ "DUF1764", "" ]

[ 1384, 1234 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1388 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 3, 3, 1, 2 ]

4

true

Family

Protein of unknown function DUF1764, eukaryotic

DUF1764_euk

6

IPR013886

13,886

PI31 proteasome regulator, C-terminal

PI31_Prot_C

Domain

2,909

false

This entry represents the C-terminal of the PI31 protein. PI31 is a cellular regulator of proteasome formation and of proteasome-mediated antigen processing [ ].

[]

0

[ "PFAM" ]

[ "PF08577" ]

[ "PI31_Prot_C" ]

[ 2909 ]

1

[ "REACTOME" ]

[ "R-HSA-9907900" ]

[ "REACTOME:R-HSA-9907900" ]

1

[ "7teo", "8fz6" ]

2

[ "PUB00033312" ]

[ "12374861" ]

[ "PI31 is a modulator of proteasome formation and antigen processing." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2909 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 1, 8, 4, 1, 4, 1, 1, 3 ]

8

true

Domain

PI31 proteasome regulator, C-terminal

PI31_Prot_C

9

IPR013887

13,887

Uncharacterised protein family UPF0592

UPF0592

Family

1,980

false

This entry represents a conserved region found in hypothetical proteins from fungi, mycetozoa and entamoebidae.

[]

0

[ "PFAM" ]

[ "PF08578" ]

[ "DUF1765" ]

[ 1980 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1980 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Uncharacterised protein family UPF0592

UPF0592

4

IPR013888

13,888

Ribonuclease P, Rpm2, mitochondrial

RNase_P_Rpm2_mt

Family

175

false

Ribonuclease P (RNase P) generates mature tRNA molecules by cleaving their 5' ends. Rpm2 is a protein subunit of the yeast mitochondrial RNase P. It has the ability to act as a transcriptional activator in the nucleus, where it plays a role in defining the steady-state levels of mRNAs for some nucleus-encoded mitochond...

[]

0

[ "PFAM" ]

[ "PF08579" ]

[ "RPM2" ]

[ 175 ]

1

[]

0

[]

0

[ "PUB00033322", "PUB00033602", "PUB00033603" ]

[ "16024791", "8668158", "11404323" ]

[ "Rpm2p, a component of yeast mitochondrial RNase P, acts as a transcriptional activator in the nucleus.", "Yeast mitochondrial RNase P RNA synthesis is altered in an RNase P protein subunit mutant: insights into the biogenesis of a mitochondrial RNA-processing enzyme.", "Rpm2, the protein subunit of mitochondri...

[ 2005, 1996, 2001 ]

3

[]

0

null

[ "Fungi" ]

[ 175 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Ribonuclease P, Rpm2, mitochondrial

RNase_P_Rpm2_mt

4

IPR013890

13,890

Transcriptional repressor Tup1, N-terminal

Tscrpt_rep_Tup1_N

Domain

2,057

false

The N-terminal region of the Tup protein has been shown to interact with the Ssn6 transcriptional co-repressor [ ].

[]

0

[ "PFAM" ]

[ "PF08581" ]

[ "Tup_N" ]

[ 2057 ]

1

[]

0

[ "3vp8", "3vp9" ]

2

[ "PUB00033338" ]

[ "12234489" ]

[ "Mutations of the WD repeats that compromise Tup1 repression function maintain structural integrity of the WD domain trypsin-resistant core." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2057 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2 ]

3

true

Domain

Transcriptional repressor Tup1, N-terminal

Tscrpt_rep_Tup1_N

4

IPR013892

13,892

Cytochrome c oxidase biogenesis protein Cmc1-like

Cyt_c_biogenesis_Cmc1-like

Family

7,459

false

Cmc1 is a metallo-chaperone like protein which is known to localise to the inner mitochondrial membrane in Saccharomyces cerevisiae. It is essential for full expression of cytochrome c oxidase and respiration [ ]. Cmc1 contains two Cx9C motifs and is able to bind copper(I). Cmc1 is thought to play a role in mitochondri...

[]

0

[ "PFAM" ]

[ "PF08583" ]

[ "Cmc1" ]

[ 7459 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9864848", "R-HSA-1268020", "R-HSA-9864848", "R-MMU-9864848" ]

[ "REACTOME:R-BTA-9864848", "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-9864848", "REACTOME:R-MMU-9864848" ]

4

[ "8a22", "8apn", "8apo" ]

3

[ "PUB00044676" ]

[ "18443040" ]

[ "Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota" ]

[ 7459 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 2, 3, 3, 12, 8, 2, 5, 13, 2, 2, 5 ]

12

true

Family

Cytochrome c oxidase biogenesis protein Cmc1-like

Cyt_c_biogenesis_Cmc1-like

4

IPR013893

13,893

Ribonuclease P protein subunit Rpp40

RNase_P_Rpp40

Family

3,224

false

Ribonuclease P (Rnp) is a ubiquitous ribozyme that catalyzes a Mg2 -dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) in all three domains of life [ ]. In bacteria, the catalytic RNA (typically ~120kDa) is aided by a small protein cofactor (~14kDa) [ ]. Archaeal and eukaryote RNase P co...

[ "GO:0001682", "GO:0030677" ]

[ "tRNA 5'-leader removal", "ribonuclease P complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF08584", "PTHR15396" ]

[ "Ribonuc_P_40", "" ]

[ 3202, 3092 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6784531", "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226" ]

[ "REACTOME:R-HSA-6784531", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226" ]

4

[ "6ahr", "6ahu", "6ahv" ]

3

[ "PUB00006321", "PUB00007201", "PUB00088366" ]

[ "7731988", "10024167", "28971852" ]

[ "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.", "Rpp14 and Rpp29, two protein subunits of human ribonuclease P.", "Chance and necessity in the evolution of RNase P." ]

[ 1995, 1999, 2018 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3224 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 4, 3, 1, 6, 1 ]

6

true

Family

Ribonuclease P protein subunit Rpp40

RNase_P_Rpp40

1

IPR013894

13,894

RecQ mediated genome instability protein 1, OB-fold domain

RMI1_OB

Domain

6,853

false

This entry represents the the OB-fold domain of RMI1 (RecQ-mediated genome instability protein 1) and similar proteins [ ]. This domain forms a stable complex with Bloom syndrome protein BLM and DNA topoisomerase 3-alpha [ ].

[]

0

[ "PFAM" ]

[ "PF08585" ]

[ "RMI1_N_C" ]

[ 6853 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-5685938", "R-BTA-5685942", "R-BTA-5693568", "R-BTA-5693579", "R-BTA-5693607", "R-BTA-5693616", "R-BTA-6804756", "R-BTA-69473", "R-HSA-5685938", "R-HSA-5685942", "R-HSA-5693554", "R-HSA-5693568", "R-HSA-5693579", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6804756", "R-HSA-69473",...

[ "REACTOME:R-BTA-5685938", "REACTOME:R-BTA-5685942", "REACTOME:R-BTA-5693568", "REACTOME:R-BTA-5693579", "REACTOME:R-BTA-5693607", "REACTOME:R-BTA-5693616", "REACTOME:R-BTA-6804756", "REACTOME:R-BTA-69473", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5685942", "REACTOME:R-HSA-5693554", "REACTOME:...

30

[ "3nbi", "4cgy", "4cht", "5gvd", "5gve", "9c9w", "9c9y", "9ca0", "9ca1", "9ca4", "9cag", "9cah", "9caj", "9cak", "9cal" ]

15

[ "PUB00075424", "PUB00075425" ]

[ "18923082", "18923083" ]

[ "RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.", "BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome." ]

[ 2008, 2008 ]

2

[]

0

null

[ "Eukaryota" ]

[ 6853 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 3, 8, 1, 5, 3, 1, 7, 6, 1, 1, 11 ]

12

true

Domain

RecQ mediated genome instability protein 1, OB-fold domain

RMI1_OB

6

IPR013895

13,895

Chromatin structure-remodeling complex protein Rsc14

Rsc14

Family

58

false

RSC is an ATP-dependent chromatin remodelling complex found in yeast. The RSC components Rsc7/Npl6 and Rsc14/Ldb7 interact physically and/or functionally with Rsc3, Rsc30, and Htl1 to form a module important for a broad range of RSC functions [ ].

[ "GO:0006338", "GO:0016586" ]

[ "chromatin remodeling", "RSC-type complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08586" ]

[ "Rsc14" ]

[ 58 ]

1

[]

0

[ "6v8o", "6v92" ]

2

[ "PUB00033276" ]

[ "16204215" ]

[ "The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles." ]

[ 2006 ]

1

[]

0

null

[ "Saccharomycetaceae" ]

[ 58 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Chromatin structure-remodeling complex protein Rsc14

Rsc14

2

IPR013896

13,896

Carbon catabolite-derepressing protein kinase, ubiquitin-associated domain

SNF1_UBA

Domain

1,672

false

This ubiquitin-associated (UBA) domain is found in yeast carbon catabolite-derepressing protein kinases (Snf1) and similar proteins from fungi. Mutations in this domain significantly alter SNF1 kinase activation and biological activity [ ]. Snf1, also called yeast adenosine monophosphate (AMP)-activated protein kinase ...

[ "GO:0004674" ]

[ "protein serine/threonine kinase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "CDD" ]

[ "PF08587", "cd14334" ]

[ "UBA_2", "UBA_SNF1_fungi" ]

[ 1604, 1500 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.11.1", "R-SCE-1632852", "R-SCE-163680", "R-SCE-200425", "R-SCE-380972", "R-SPO-1632852", "R-SPO-163680", "R-SPO-200425", "R-SPO-380972", "R-SPO-5628897" ]

[ "EC:2.7.11.1", "REACTOME:R-SCE-1632852", "REACTOME:R-SCE-163680", "REACTOME:R-SCE-200425", "REACTOME:R-SCE-380972", "REACTOME:R-SPO-1632852", "REACTOME:R-SPO-163680", "REACTOME:R-SPO-200425", "REACTOME:R-SPO-380972", "REACTOME:R-SPO-5628897" ]

10

[ "3h4j" ]

1

[ "PUB00042779", "PUB00080318", "PUB00080319", "PUB00080320", "PUB00080324", "PUB00080326" ]

[ "17981722", "8985180", "17438333", "23472170", "12546680", "25869125" ]

[ "SNF1/AMPK pathways in yeast.", "Glucose regulates protein interactions within the yeast SNF1 protein kinase complex.", "Regulation of snf1 protein kinase in response to environmental stress.", "The AMPK family member Snf1 protects Saccharomyces cerevisiae cells upon glutathione oxidation.", "Snf1 protein k...

[ 2008, 1996, 2007, 2013, 2003, 2015 ]

6

[]

0

null

[ "Eukaryota" ]

[ 1672 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Carbon catabolite-derepressing protein kinase, ubiquitin-associated domain

SNF1_UBA

7

IPR013897

13,897

Domain of unknown function at the cortex 1

Duc1

Domain

2,936

false

This entry includes the Duc1 (Domain of Unknown Function at the Cortex 1) protein, which is involved in maintaining proper plasma membrane lipid composition and cytokinetic ring anchoring in Schizosaccharomyces pombe [ ]. Duc1 localises to the plasma membrane, except at the cell division site, and its localization is c...

[]

0

[ "PFAM" ]

[ "PF08588" ]

[ "Duc1" ]

[ 2936 ]

1

[]

0

[]

0

[ "PUB00155608" ]

[ "39239853" ]

[ "Fission yeast Duc1 links to ER-PM contact sites and influences PM lipid composition and cytokinetic ring anchoring." ]

[ 2024 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2936 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2 ]

2

true

Domain

Domain of unknown function at the cortex 1

Duc1

5

IPR013900

13,900

Ribonucleotide reductase inhibitor

RNR_inhibitor

Family

1,193

false

This entry includes Schizosaccharomyces pombe (Fission yeast) Spd1. Spd1p inhibits fission yeast RNR activity by interacting with the Cdc22p [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08591", "PTHR28081" ]

[ "RNR_inhib", "" ]

[ 1167, 1045 ]

2

[]

0

[]

0

[ "PUB00033320" ]

[ "16317005" ]

[ "The Schizosaccharomyces pombe replication inhibitor Spd1 regulates ribonucleotide reductase activity and dNTPs by binding to the large Cdc22 subunit." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1193 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2 ]

3

true

Family

Ribonucleotide reductase inhibitor

RNR_inhibitor

4

IPR013901

13,901

Anthrone oxygenase

MdpH-2

Family

10,253

false

This family consists of anthrone oxygenases found in bacteria and fungi, and similar proteins involved in the synthesis of different products. GedH from Aspergillus terreus is part of the gene cluster that mediates the biosynthesis of geodin [ ], EncC from Neosartorya fumigata is involved in the biosynthesis of endocro...

[]

0

[ "PFAM" ]

[ "PF08592" ]

[ "Anthrone_oxy" ]

[ 10253 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.10.3.-", "PWY-5399", "PWY-5404", "PWY-5439", "PWY-5476", "PWY-5780", "PWY-5787", "PWY-7079" ]

[ "EC:1.10.3.-", "METACYC:PWY-5399", "METACYC:PWY-5404", "METACYC:PWY-5439", "METACYC:PWY-5476", "METACYC:PWY-5780", "METACYC:PWY-5787", "METACYC:PWY-7079" ]

8

[]

0

[ "PUB00081405", "PUB00081406", "PUB00081407", "PUB00086983" ]

[ "24009710", "22492455", "21351751", "20139316" ]

[ "Heterologous reconstitution of the intact geodin gene cluster in Aspergillus nidulans through a simple and versatile PCR based approach.", "Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus.", "Genome-based deletion analysis reveals the prenyl xanthone biosynthes...

[ 2013, 2012, 2011, 2010 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "metagenomes" ]

[ 6513, 3723, 8, 9 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Family

Anthrone oxygenase

MdpH-2

1

IPR013902

13,902

Mug135-like, C-terminal domain

Mug135-like_C

Domain

569

false

This entry represents a conserved domain found at the C-terminal end of certain meiotically up-regulated gene products (MUG) from fungi [ ], including Meiotically up-regulated gene 135 protein from Schizosaccharomyces pombe (Mug135, also known as Tdk1, ). Mug135 is a killer meiotic driver (KMD), a selfish genetic eleme...

[]

0

[ "PFAM" ]

[ "PF08593" ]

[ "Mug135_C" ]

[ 569 ]

1

[]

0

[ "9ja5", "9ja6" ]

2

[ "PUB00044889", "PUB00053363", "PUB00159004", "PUB00159007" ]

[ "16303567", "16823372", "39485795", "39485800" ]

[ "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.", "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.", "A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring.", "St...

[ 2005, 2006, 2024, 2024 ]

4

[]

0

null

[ "Eukaryota" ]

[ 569 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 7 ]

1

true

Domain

Mug135-like, C-terminal domain

Mug135-like_C

6

IPR013903

13,903

Meiotic expression up-regulated protein

Meiotic_expression

Family

24

false

This family of proteins appear to be specific to Schizosaccharomyces (Fission yeast). Their exact function is unknown, but they are up-regulated in meiosis and some of them have been shown to be required for critical meiotic events [ ].

[]

0

[ "PFAM" ]

[ "PF08594" ]

[ "UPF0300" ]

[ 24 ]

1

[]

0

[]

0

[ "PUB00044889" ]

[ "16303567" ]

[ "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events." ]

[ 2005 ]

1

[]

0

null

[ "Schizosaccharomyces" ]

[ 24 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 6 ]

1

true

Family

Meiotic expression up-regulated protein

Meiotic_expression

2

IPR013904

13,904

Transcriptional regulatory protein RXT2, N-terminal

RXT2_N

Domain

1,338

false

The entry represents the N-terminal region of RXT2. RXT2, also known as RAF60, is a component of the Rpd3 histone deacetylase complex (HDAC). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events [ ].

[]

0

[ "PFAM" ]

[ "PF08595" ]

[ "RXT2_N" ]

[ 1338 ]

1

[]

0

[ "8ga8", "8hpo", "8i03" ]

3

[ "PUB00057841" ]

[ "16275642" ]

[ "Raf60, a novel component of the Rpd3 histone deacetylase complex required for Rpd3 activity in Saccharomyces cerevisiae." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1338 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Transcriptional regulatory protein RXT2, N-terminal

RXT2_N

4

IPR013905

13,905

Lethal giant larvae (Lgl)-like, C-terminal domain

Lgl_C_dom

Domain

5,951

false

The Lethal giant larvae (Lgl) tumour suppressor protein is conserved from yeast to mammals. The Lgl protein functions in cell polarity, at least in part, by regulating SNARE-mediated membrane delivery events at the cell surface [ ]. The N-terminal half of Lgl members contains WD40 repeats (see ), while the C-terminal h...

[]

0

[ "PFAM" ]

[ "PF08596" ]

[ "Lgl_C" ]

[ 5951 ]

1

[]

0

[ "2oaj", "9y48" ]

2

[ "PUB00033291" ]

[ "15964280" ]

[ "Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular function." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5951 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 3, 17, 1, 10, 8, 1, 4, 18, 2, 1, 11 ]

11

true

Domain

Lethal giant larvae (Lgl)-like, C-terminal domain

Lgl_C_dom

3

IPR013906

13,906

Eukaryotic translation initiation factor 3 subunit J

eIF3j

Family

5,049

false

This shows protein subunits of the eukaryotic translation initiation factor 3 J (eIF3j). It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribo...

[ "GO:0003743", "GO:0005737", "GO:0005852" ]

[ "translation initiation factor activity", "cytoplasm", "eukaryotic translation initiation factor 3 complex" ]

[ "molecular_function", "cellular_component", "cellular_component" ]

3

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_03009", "PF08597", "PTHR21681" ]

[ "eIF3j", "eIF3_subunit", "" ]

[ 3560, 5032, 4784 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-DDI-156827", "R-DDI-72689", "R-DDI-72695", "R-DDI-72702", "R-DME-156827", "R-DME-72649", "R-DME-72689", "R-DME-72695", "R-DME-72702", "R-DRE-156827", "R-DRE-72689", "R-DRE-72695", "R-DRE-72702", "R-GGA...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-72689", "REACTOME:R-DDI-72695", "REACTOME:R-DDI-72702", "REACTOME:R-DME-156827", "REACTOME:R-DME-72649", "REACTOME:R-DME-72689", "...

53

[ "3bpj", "6ybw", "6zce", "6zmw", "6zvj", "7a1g", "8cah" ]

7

[ "PUB00005773", "PUB00033288", "PUB00064796" ]

[ "8995409", "11387228", "14688252" ]

[ "Conservation and diversity of eukaryotic translation initiation factor eIF3.", "A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met.", "The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomp...

[ 1997, 2001, 2004 ]

3

[]

0

null

[ "Eukaryota" ]

[ 5049 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 3, 2, 3, 5, 1, 5, 4, 1, 1, 11 ]

12

true

Family

Eukaryotic translation initiation factor 3 subunit J

eIF3j

2

IPR013907

13,907

Sds3-like

Sds3

Family

8,532

false

Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins [ ]. This entry represents...

[]

0

[ "PFAM", "PANTHER", "SMART" ]

[ "PF08598", "PTHR21964", "SM01401" ]

[ "Sds3", "", "Sds3" ]

[ 7998, 7472, 7836 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3214815", "R-HSA-3214815", "R-HSA-427413", "R-HSA-5689880", "R-HSA-9679191", "R-MMU-3214815", "R-MMU-5689880", "R-RNO-3214815", "R-SCE-3214815", "R-SCE-5689880", "R-SPO-3214815", "R-SPO-5689880" ]

[ "REACTOME:R-BTA-3214815", "REACTOME:R-HSA-3214815", "REACTOME:R-HSA-427413", "REACTOME:R-HSA-5689880", "REACTOME:R-HSA-9679191", "REACTOME:R-MMU-3214815", "REACTOME:R-MMU-5689880", "REACTOME:R-RNO-3214815", "REACTOME:R-SCE-3214815", "REACTOME:R-SCE-5689880", "REACTOME:R-SPO-3214815", "REACTOME...

12

[ "4zqa", "7sxi", "8ga8", "8hpo", "8i03" ]

5

[ "PUB00033327" ]

[ "15451426" ]

[ "Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota", "Microcystis aeruginosa BLCC-F158" ]

[ 8531, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 11, 3, 13, 7, 2, 14, 2, 2 ]

8

true

Family

Sds3-like

Sds3

8

IPR013908

13,908

Nibrin, C-terminal

Nibrin_C

Domain

1,214

false

This is the C-terminal region of Nibrin (also known as DNA damage repair protein Nbs1) that has been identified to be necessary for the binding of Mre11 and Tel1 [ ]. Nibrin (also known as Nbs1 or p95) plays an important role in the DNA damage response (DDR) and DNA repair. It is part of the nuclear MRN complex, which ...

[]

0

[ "PFAM", "SMART" ]

[ "PF08599", "SM01348" ]

[ "Nbs1_C", "Nbs1_C" ]

[ 1161, 1203 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DRE-5693548", "R-GGA-217106", "R-GGA-351433", "R-GGA-351442", "R-GGA-351444", "R-HSA-2559586", "R-HSA-5685938", "R-HSA-5685939", "R-HSA-5685942", "R-HSA-5693548", "R-HSA-5693554", "R-HSA-5693565", "R-HSA-5693568", "R-HSA-5693571", "R-HSA-5693579", "R-HSA-5693607", "R-HSA-5693616",...

[ "REACTOME:R-DRE-5693548", "REACTOME:R-GGA-217106", "REACTOME:R-GGA-351433", "REACTOME:R-GGA-351442", "REACTOME:R-GGA-351444", "REACTOME:R-HSA-2559586", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5685939", "REACTOME:R-HSA-5685942", "REACTOME:R-HSA-5693548", "REACTOME:R-HSA-5693554", "REACTOME:R-...

51

[ "7sid", "8bah", "9q9i", "9q9j", "9q9m" ]

5

[ "PUB00033299", "PUB00062775", "PUB00073633", "PUB00073634", "PUB00073635", "PUB00073636", "PUB00073637", "PUB00073638", "PUB00073639" ]

[ "15964794", "9705271", "22373003", "25119968", "12422221", "10888888", "19759395", "15668383", "11448772" ]

[ "ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.", "Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.", "Nijmegen breakage syndrome (NBS).", "The role of nibrin in doxorubicin-induced apoptosis and cell senescence...

[ 2005, 1998, 2012, 2014, 2002, 2000, 2009, 2005, 2001 ]

9

[]

0

null

[ "Eukaryota" ]

[ 1214 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 4, 12, 1, 1, 4 ]

5

true

Domain

Nibrin, C-terminal

Nibrin_C

5

IPR013909

13,909

NuBaID, C-terminal domain

NuBaID_C

Domain

3,637

false

This entry represents the C-terminal zinc finger domain of Zinc finger C3HC-type protein 1 (ZC3HC1, also known as Nuclear-interacting partner of ALK (NIPA)) and mRNA export factor Rsm1 which is a homologue from S. pombe. These proteins contain a C3HC-type zinc finger ( ) at the N terminus followed by the domain represe...

[ "GO:0008270" ]

[ "zinc ion binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF08600" ]

[ "NuBaID_C" ]

[ 3637 ]

1

[ "REACTOME" ]

[ "R-HSA-9725371" ]

[ "REACTOME:R-HSA-9725371" ]

1

[]

0

[ "PUB00014077", "PUB00016374", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812", "PUB00053671", "PUB00154435", "PUB00154436", "PUB00154437", "PUB00154463", "PUB00154464" ]

[ "12665246", "15357289", "17210253", "15963892", "15718139", "10529348", "11179890", "16009132", "34440706", "35609216", "36857168", "36271106", "16162818" ]

[ "Zinc fingers--folds for many occasions.", "Schizosaccharomyces pombe rsm1 genetically interacts with spmex67, which is involved in mRNA export.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a gri...

[ 2002, 2004, 2007, 2005, 2005, 1999, 2001, 2005, 2021, 2022, 2023, 2022, 2005 ]

13

[]

0

null

[ "Biformimicrobium ophioploci", "Eukaryota" ]

[ 1, 3636 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 10, 2, 4, 4, 1, 6, 3, 1, 18 ]

9

true

Domain

NuBaID, C-terminal domain

NuBaID_C

2

IPR013910

13,910

Transcription factor PAP1

TF_PAP1

Domain

1,985

false

The transcription factor Pap1 regulates antioxidant-gene transcription in response to H2O2 [ ]. This region is cysteine rich. Alkylation of cysteine residues following treatment with a cysteine alkylating agent can mask the accessibility of the nuclear exporter Crm1, triggering nuclear accumulation and Pap1 dependent t...

[]

0

[ "PFAM" ]

[ "PF08601" ]

[ "PAP1" ]

[ 1985 ]

1

[]

0

[ "1sse" ]

1

[ "PUB00033307", "PUB00033308" ]

[ "15956211", "12100563" ]

[ "A cysteine-sulfinic acid in peroxiredoxin regulates H2O2-sensing by the antioxidant Pap1 pathway.", "Diethylmaleate activates the transcription factor Pap1 by covalent modification of critical cysteine residues." ]

[ 2005, 2002 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1985 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 2, 1 ]

3

true

Domain

Transcription factor PAP1

TF_PAP1

7

IPR013911

13,911

Mitochondrial inner membrane i-AAA protease complex subunit Mgr1

i-AAA_Mgr1

Family

138

false

This entry represents Mitochondrial inner membrane i-AAA protease complex subunit MGR1 and similar proteins from Saccharomycetes. Mgr1 has been shown to be required for mitochondrial viability in yeast lacking mitochondrial DNA. It is a mitochondrial inner membrane protein, which interacts with Yme1 and is a subunit of...

[ "GO:0005743" ]

[ "mitochondrial inner membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF08602" ]

[ "Mgr1" ]

[ 138 ]

1

[]

0

[]

0

[ "PUB00033295", "PUB00033614", "PUB00090697" ]

[ "16267274", "8861950", "18843051" ]

[ "A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex.", "AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP-dependent degradation of inner membrane proteins in mitochondria.", "Mgr3p and Mgr1p are adapto...

[ 2006, 1996, 2008 ]

3

[]

0

null

[ "Dikarya" ]

[ 138 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mitochondrial inner membrane i-AAA protease complex subunit Mgr1

i-AAA_Mgr1

4

IPR013912

13,912

Adenylate cyclase-associated CAP, C-terminal

Adenylate_cyclase-assoc_CAP_C

Domain

6,929

false

Cyclase-associated proteins (CAPs) are highly conserved actin-binding proteins present in a wide range of organisms including yeast, fly, plants, and mammals. CAPs are multifunctional proteins that contain several structural domains. CAP is involved in species-specific signalling pathways [ , , , ]. In Drosophila, CAP ...

[ "GO:0003779", "GO:0007010" ]

[ "actin binding", "cytoskeleton organization" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF08603" ]

[ "CAP_C" ]

[ 6929 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6798695", "R-HSA-114608", "R-HSA-428890", "R-HSA-6798695", "R-MMU-6798695", "R-RNO-6798695", "R-SCE-6798695", "R-SPO-6798695" ]

[ "REACTOME:R-DDI-6798695", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-428890", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-6798695", "REACTOME:R-SCE-6798695", "REACTOME:R-SPO-6798695" ]

8

[ "1k4z", "1k8f", "1kq5", "2b0r", "6fm2" ]

5

[ "PUB00007159", "PUB00026629", "PUB00042568", "PUB00042569", "PUB00042570", "PUB00042571", "PUB00042579", "PUB00042580" ]

[ "12351838", "15311924", "11919151", "17635992", "10658207", "10594005", "17376963", "15004221" ]

[ "Crystallization of cyclase-associated protein from Dictyostelium discoideum.", "Crystal structure of the actin binding domain of the cyclase-associated protein.", "Cyclase-associated proteins: CAPacity for linking signal transduction and actin polymerization.", "Arabidopsis CAP1 - a key regulator of actin or...

[ 2002, 2004, 2002, 2007, 2000, 2000, 2007, 2004 ]

8

[ "IPR017901" ]

[]

1

0

1

[ "Eukaryota", "Viruses", "metagenomes" ]

[ 6917, 9, 3 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 4, 3, 3, 13, 9, 1, 5, 9, 1, 1, 18 ]

12

true

Domain

Adenylate cyclase-associated CAP, C-terminal

Adenylate_cyclase-assoc_CAP_C

4

IPR013913

13,913

Nucleoporin Nup153, N-terminal

Nup153_N

Domain

1,579

false

Nuclear pore complex protein Nup153 is a component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. The N-terminal domain of Nup153 has NPC targeting activity and is found before the middle domain, which contains four zinc finger motifs of the C2C2-type [ , ].

[]

0

[ "PFAM" ]

[ "PF08604" ]

[ "Nup153" ]

[ 1579 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R-HSA-165054", "R-HSA-168271", "R-HSA-168276", "R-HSA-168325", "R-HSA-168333", "R-HSA-170822", "R-HSA-180746", "R-HSA-180910", "R-HSA-191859", "R-HSA-3108214", "R-HSA-3232142", "R-HSA-3301854", "R-HSA...

[ "REACTOME:R-HSA-1169408", "REACTOME:R-HSA-159227", "REACTOME:R-HSA-159230", "REACTOME:R-HSA-159231", "REACTOME:R-HSA-159236", "REACTOME:R-HSA-165054", "REACTOME:R-HSA-168271", "REACTOME:R-HSA-168276", "REACTOME:R-HSA-168325", "REACTOME:R-HSA-168333", "REACTOME:R-HSA-170822", "REACTOME:R-HSA-18...

58

[]

0

[ "PUB00075544", "PUB00075547" ]

[ "10202161", "9745047" ]

[ "Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain.", "Amino-terminal sequences that direct nucleoporin nup153 to the inner surface of the nuclear envelope." ]

[ 1999, 1998 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1579 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 30, 1, 5, 6 ]

4

true

Domain

Nucleoporin Nup153, N-terminal

Nup153_N

5

IPR013914

13,914

Rad9-like Rad53-binding domain, fungi

Rad9_Rad53-bd_dom_fun

Domain

359

false

This entry represents a Rad53 binding domain (tudor domain) from yeast Rad9. In Saccharomyces cerevisiae (Baker s yeast), Rad9 is a key adaptor protein in DNA damage checkpoint pathways. DNA damage induces Rad9 phosphorylation and promotes the interaction between Rad9 and phosphorylated Rad53 [ ]. This interaction is a...

[]

0

[ "PFAM" ]

[ "PF08605" ]

[ "Rad9_Rad53_bind" ]

[ 359 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-SCE-3232118", "R-SCE-5693565" ]

[ "REACTOME:R-SCE-3232118", "REACTOME:R-SCE-5693565" ]

2

[]

0

[ "PUB00005866", "PUB00020219" ]

[ "10518219", "9755168" ]

[ "The FHA domain is a modular phosphopeptide recognition motif.", "The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage." ]

[ 1999, 1998 ]

2

[]

0

null

[ "Dikarya" ]

[ 359 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

Rad9-like Rad53-binding domain, fungi

Rad9_Rad53-bd_dom_fun

3

IPR013915

13,915

Prp19, coiled-coil region

Prp19_cc

Domain

4,947

false

This entry represents the coiled-coil region of Prp19. Prp19, also known as DNA repair protein Pso4 (psoralen-sensitive mutant 4), is a ubiquitously expressed multifunctional E3 ubiquitin ligase with pleiotropic activities in DNA damage signalling, repair, and replicative senescence. It functions as a critical componen...

[]

0

[ "PFAM" ]

[ "PF08606" ]

[ "Prp19" ]

[ 4947 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "2.3.2.27", "PWY-7511", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-72163", "R-CEL-6781823", "R-CEL-6782135", "R-CEL-6782210", "R-CEL-72163", "R-DDI-6781823", "R-DDI-6782135", "R-DDI-6782210", "R-DDI-72163", "R-HSA-6781823", "R-HSA-6781827", "R-HSA-6782135", "R-HSA-67...

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-72163", "REACTOME:R-CEL-6781823", "REACTOME:R-CEL-6782135", "REACTOME:R-CEL-6782210", "REACTOME:R-CEL-72163", "REACTOME:R-DDI-6781823", "REACTOME:R-DDI-6782135", "...

34

[ "3jb9", "5gm6", "5gmk", "5lj5", "5m88", "5mq0", "5mqf", "5wsg", "5xjc", "5y88", "5ylz", "5yzg", "5z56", "5z57", "6bk8", "6exn", "6ff7", "6icz", "6id0", "6id1", "6j6g", "6j6h", "6j6n", "6j6q", "6qdv", "7a5p", "7b9v", "7dco", "7w59", "7w5a", "7w5b", "8c6j"...

48

[ "PUB00027592", "PUB00033314", "PUB00039586", "PUB00067554", "PUB00078520", "PUB00090460", "PUB00092514", "PUB00137580", "PUB00137581", "PUB00137582", "PUB00137583", "PUB00155379" ]

[ "12627222", "16332694", "16388587", "20595234", "24332808", "17981804", "28502770", "21536736", "26292707", "26364595", "26130721", "28962858" ]

[ "Structural insights into the U-box, a domain associated with multi-ubiquitination.", "SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly.", "The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquit...

[ 2003, 2005, 2006, 2010, 2014, 2008, 2017, 2011, 2015, 2016, 2015, 2017 ]

12

[]

0

null

[ "Eukaryota", "Kitasatospora terrestris" ]

[ 4946, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 1, 1, 3, 1, 1, 1, 9, 1, 1, 17 ]

12

true

Domain

Prp19, coiled-coil region

Prp19_cc

4

IPR013919

13,919

Peroxisome membrane protein, Pex16

Pex16

Family

4,474

false

Pex16 is a peripheral protein located at the matrix face of the peroxisomal membrane [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08610", "PTHR13299" ]

[ "Pex16", "" ]

[ 4463, 4283 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9603798", "R-DDI-9603798", "R-DRE-9603798", "R-HSA-9603798", "R-MMU-9603798", "R-SPO-9603798", "R-XTR-9603798" ]

[ "REACTOME:R-BTA-9603798", "REACTOME:R-DDI-9603798", "REACTOME:R-DRE-9603798", "REACTOME:R-HSA-9603798", "REACTOME:R-MMU-9603798", "REACTOME:R-SPO-9603798", "REACTOME:R-XTR-9603798" ]

7

[]

0

[ "PUB00033311" ]

[ "9182661" ]

[ "Enlarged peroxisomes are present in oleic acid-grown Yarrowia lipolytica overexpressing the PEX16 gene encoding an intraperoxisomal peripheral membrane peroxin." ]

[ 1997 ]

1

[]

0

null

[ "Eukaryota", "Halomonas marinisediminis" ]

[ 4473, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Ze...

[ 3, 2, 1, 5, 2, 1, 4, 7, 1, 9 ]

10

true

Family

Peroxisome membrane protein, Pex16

Pex16

1

IPR013920

13,920

Protein of unknown function DUF1774, fungi

DUF1774_fun

Family

1,500

false

This is a fungal protein of unknown function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08611", "PTHR37992" ]

[ "DUF1774", "" ]

[ 1052, 1483 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 3, 1497 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Protein of unknown function DUF1774, fungi

DUF1774_fun

9

IPR013921

13,921

Mediator complex, subunit Med20

Mediator_Med20

Family

3,396

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF08612", "PTHR12465" ]

[ "Med20", "" ]

[ 3368, 2503 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-9841922", "R-GGA-212436", "R-GGA-9841922", "R-HSA-1989781", "R-HSA-212436", "R-HSA-381340", "R-HSA-9833110", "R-HSA-9841922", "R-RNO-9841922" ]

[ "REACTOME:R-DME-9841922", "REACTOME:R-GGA-212436", "REACTOME:R-GGA-9841922", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-212436", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9841922", "REACTOME:R-RNO-9841922" ]

9

[ "2hzm", "2hzs", "3j1o", "3rj1", "4gwp", "4gwq", "4v1o", "5n9j", "5oqm", "5sva", "5u0p", "5u0s", "6w1s", "7emf", "7ena", "7enc", "7enj", "7lbm", "7nvr", "7ui9", "7uif", "7uig", "7uio", "8cen", "8ceo", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw", "8trh"...

32

[ "PUB00033332", "PUB00033372" ]

[ "9933582", "15175151" ]

[ "The human homologue of Drosophila TRF-proximal protein is associated with an RNA polymerase II-SRB complex.", "A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II." ]

[ 1999, 2004 ]

2

[]

[ "IPR016532" ]

0

1

0

[ "Eukaryota" ]

[ 3396 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea ma...

[ 11, 2, 2, 2, 5, 2, 2, 6, 1, 1, 5 ]

11

true

Family

Mediator complex, subunit Med20

Mediator_Med20

5

IPR013922

13,922

Cyclin PHO80-like

Cyclin_PHO80-like

Family

22,407

false

Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [ ], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essenti...

[ "GO:0019901", "GO:0000079" ]

[ "protein kinase binding", "regulation of cyclin-dependent protein serine/threonine kinase activity" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF08613", "PTHR15615" ]

[ "Cyclin", "" ]

[ 17587, 21478 ]

2

[]

0

[ "2pk9", "2pmi", "4krc", "4krd" ]

4

[ "PUB00014101", "PUB00014103", "PUB00033650", "PUB00055074" ]

[ "11056549", "12910258", "8108735", "15197472" ]

[ "Cyclin' on the viral path to destruction.", "Cell cycle regulation and neural differentiation.", "Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85.", "Molecular characterization of Arabidopsis PHO80-like proteins, a novel class of CDKA;1-interacting cyclins." ]

[ 2000, 2003, 1994, 2004 ]

4

[]

[ "IPR012104", "IPR012389" ]

0

2

0

[ "Bacteria", "Eukaryota", "Viruses", "organismal metagenomes" ]

[ 11, 22384, 4, 8 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 27, 1, 1, 2, 5, 6, 7, 25, 3, 10, 3, 24 ]

12

true

Family

Cyclin PHO80-like

Cyclin_PHO80-like

8

IPR013923

13,923

Autophagy-related protein 16 domain

Autophagy-rel_prot_16_dom

Domain

5,545

false

This entry represents the coiled-coil domain (CC) of autophagy protein 16 (Apg16), which is required for self-assembly. Atg16 is required for the function of the Apg12p-Apg5p conjugate. Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the forma...

[]

0

[ "PFAM" ]

[ "PF08614" ]

[ "ATG16" ]

[ 5545 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-1632852", "R-HSA-1632852", "R-MMU-1632852", "R-XTR-1632852" ]

[ "REACTOME:R-DDI-1632852", "REACTOME:R-HSA-1632852", "REACTOME:R-MMU-1632852", "REACTOME:R-XTR-1632852" ]

4

[ "3a7p", "4tq0", "5d7g", "5npv", "5npw", "6rgo", "6sur", "6y09", "6zay", "7xfr", "8zqg" ]

11

[ "PUB00009838", "PUB00009839", "PUB00033271", "PUB00097434" ]

[ "10712513", "11689437", "10406794", "2306415" ]

[ "Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways.", "The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.", "Apg16p is required for the function of the Apg12p-Apg5p conjugate in the ye...

[ 2000, 2001, 1999, 1990 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Haloarcula", "marine sediment metagenome" ]

[ 11, 5519, 13, 2 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 4, 2, 2, 20, 7, 1, 3, 12, 1, 5 ]

10

true

Domain

Autophagy-related protein 16 domain

Autophagy-rel_prot_16_dom

1

IPR013924

13,924

Ribonuclease H2, subunit C

RNase_H2_suC

Family

3,756

false

Whereas bacterial and archaeal RNases H2 are active as single polypeptides, eukaryotic RNase H2 is a heterotrimeric complex of the RNase H2A, RNase H2B, and RNase H2C proteins that are all required for proper function and activity , ]. RNase H2 is an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. I...

[ "GO:0006401", "GO:0032299" ]

[ "RNA catabolic process", "ribonuclease H2 complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "CDD" ]

[ "PF08615", "cd09271" ]

[ "RNase_H2_suC", "RNase_H2-C" ]

[ 3742, 3237 ]

2

[]

0

[ "3kio", "3p56", "3p5j", "3puf", "8yjz" ]

5

[ "PUB00044465", "PUB00079406" ]

[ "14734815", "19923215" ]

[ "RNase H2 of Saccharomyces cerevisiae is a complex of three proteins.", "The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction." ]

[ 2004, 2010 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3756 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 5, 1, 1, 2, 3, 4, 1, 2, 5, 1, 7 ]

11

true

Family

Ribonuclease H2, subunit C

RNase_H2_suC

1

IPR013926

13,926

CGI121/TPRKB

Family

4,881

false

This entry represents the EKC/KEOPS complex subunit Cgi121 from fungi and its homologue, TPRKB from mammals. This entry also includes archaeal homologues [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08617", "PTHR15840" ]

[ "CGI-121", "" ]

[ 4871, 4056 ]

2

[ "REACTOME" ]

[ "R-HSA-6782315" ]

[ "REACTOME:R-HSA-6782315" ]

1

[ "1zd0", "2k8y", "3enh", "3enp", "4ww5", "4ww7", "4ww9", "4wwa", "4xah", "6wqx", "7kjt", "7sza", "7szb", "7szc", "7szd", "8k20", "8unk", "8up5", "9d85" ]

19

[ "PUB00033274", "PUB00035406", "PUB00048273", "PUB00059910" ]

[ "12659830", "16564010", "18951093", "21183954" ]

[ "Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein.", "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.", "Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.", "The highly conserve...

[ 2003, 2006, 2008, 2011 ]

4

[]

[ "IPR016799" ]

0

1

0

[ "Archaea", "Desulfofervidus auxilii", "Eukaryota", "ecological metagenomes" ]

[ 690, 1, 4167, 23 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "S...

[ 2, 1, 6, 4, 6, 1, 2, 6, 1, 1, 5 ]

11

true

Family

CGI121/TPRKB

3

IPR013927

13,927

Transcription factor Opi1/Ccg-8

TF_Opi1_Ccg-8

Family

1,793

false

This entry represents a family of fungal transcription factors, including Transcriptional repressor OPI1 from Saccharomyces cerevisiae and Transcription factor ccg-8 from Neurospora crassa. Opi1 is a leucine zipper containing yeast transcription factor that negatively regulates phospholipid biosynthesis [ ]. It repress...

[ "GO:0003714" ]

[ "transcription corepressor activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF08618", "PTHR38406" ]

[ "Opi1", "" ]

[ 1762, 1762 ]

2

[]

0

[]

0

[ "PUB00033304", "PUB00033670", "PUB00152808", "PUB00152809" ]

[ "16407309", "1985968", "24342650", "30603874" ]

[ "Casein kinase II phosphorylation of the yeast phospholipid synthesis transcription factor Opi1p.", "The OPI1 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper.", "Transcription factor CCG-8 as a new regula...

[ 2006, 1991, 2014, 2019 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1793 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

Transcription factor Opi1/Ccg-8

TF_Opi1_Ccg-8

9

IPR013928

13,928

Alkali metal cation/H+ antiporter Nha1, C-terminal

Cation/H_antiporter_C

Domain

1,271

false

The C terminus of the plasma membrane Nha1 antiporter plays an important role in the immediate cell response to hypo-osmotic shock which prevents an excessive loss of ions and water [ ]. This protein is found C-terminal to .

[ "GO:0015385", "GO:0006814", "GO:0016020" ]

[ "sodium:proton antiporter activity", "sodium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF08619" ]

[ "Nha1_C" ]

[ 1271 ]

1

[]

0

[]

0

[ "PUB00033301" ]

[ "16402204" ]

[ "Functional study of the Nha1p C-terminus: involvement in cell response to changes in external osmolarity." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1271 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Domain

Alkali metal cation/H+ antiporter Nha1, C-terminal

Cation/H_antiporter_C

9

IPR013929

13,929

RPAP1, C-terminal

RPAP1_C

Domain

4,285

false

This entry represents the C-terminal region that contains the motif GLHHH. This region is conserved from yeast to humans. In Saccharomyces cerevisiae (Bakers yeast), inhibition of RNA polymerase II-associated protein 1 (RPAP1) synthesis leads to global changes in gene expression that closely resemble those observed upo...

[]

0

[ "PFAM" ]

[ "PF08620" ]

[ "RPAP1_C" ]

[ 4285 ]

1

[]

0

[]

0

[ "PUB00033321" ]

[ "15282305" ]

[ "RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4285 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 6, 2, 3, 3, 2, 1, 3, 3, 1, 1, 10 ]

11

true

Domain

RPAP1, C-terminal

RPAP1_C

9

IPR013930

13,930

RPAP1, N-terminal

RPAP1_N

Domain

4,169

false

This entry represents the N-terminal region of RPAP-1 that is conserved from yeast to humans. In Saccharomyces cerevisiae (Bakers yeast), inhibition of RNA polymerase II-associated protein 1 (RPAP1) synthesis leads to global changes in gene expression that closely resemble those observed upon loss of the RNAPII subunit...

[]

0

[ "PFAM" ]

[ "PF08621" ]

[ "RPAP1_N" ]

[ 4169 ]

1

[]

0

[]

0

[ "PUB00033321" ]

[ "15282305" ]

[ "RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4169 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 2, 2, 3, 3, 3, 1, 3, 3, 1, 1, 9 ]

12

true

Domain

RPAP1, N-terminal

RPAP1_N

1

IPR013931

13,931

Svf1-like, N-terminal

Svf1-like_N

Domain

1,880

false

This entry represents the N-terminal domain of the stress survival proteins, such as survival factor 1 (Svf1). The protein Svf1 is required for yeast survival under conditions of oxidative stress, including cold stress [ ]. Cells deficient in Svf1 have increased levels of reactive oxygen species (ROS) under certain con...

[ "GO:0006979" ]

[ "response to oxidative stress" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08622" ]

[ "Svf1" ]

[ 1880 ]

1

[]

0

[]

0

[ "PUB00033375", "PUB00074949", "PUB00106854" ]

[ "16034825", "17057230", "36897280" ]

[ "Svf1 inhibits reactive oxygen species generation and promotes survival under conditions of oxidative stress in Saccharomyces cerevisiae.", "SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.", "Yeast Svf1 binds ceramides and contributes to sphingolipid metabolism at ...

[ 2005, 2007, 2023 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1880 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 3, 2 ]

3

true

Domain

Svf1-like, N-terminal

Svf1-like_N

2

IPR013932

13,932

TATA-binding protein interacting (TIP20)

TATA-bd_TIP120

Domain

5,855

false

TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription [ ].

[]

0

[ "PFAM" ]

[ "PF08623" ]

[ "TIP120" ]

[ 5855 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-6798695", "R-BTA-8951664", "R-BTA-917937", "R-CEL-6798695", "R-CEL-8951664", "R-CEL-917937", "R-DDI-6798695", "R-DDI-8951664", "R-DDI-917937", "R-DME-6798695", "R-DME-8951664", "R-DME-917937", "R-HSA-6798695", "R-HSA-8951664", "R-HSA-917937", "R-MMU-6798695", "R-MMU-8951664", ...

[ "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-8951664", "REACTOME:R-BTA-917937", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-8951664", "REACTOME:R-CEL-917937", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-8951664", "REACTOME:R-DDI-917937", "REACTOME:R-DME-6798695", "REACTOME:R-DME-8951664", "REACTOME:R...

24

[ "1u6g", "4a0c", "7z8r", "7z8t", "7z8v", "7zbw", "7zbz", "8cdj", "8cdk", "8h3q", "8or0", "8or2", "8or3", "8or4", "8vvy" ]

15

[ "PUB00033334" ]

[ "10567521" ]

[ "TATA-Binding protein-interacting protein 120, TIP120, stimulates three classes of eukaryotic transcription via a unique mechanism." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5855 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 6, 1, 2, 3, 8, 4, 1, 2, 12, 1, 23 ]

11

true

Domain

TATA-binding protein interacting (TIP20)

TATA-bd_TIP120

7

IPR013933

13,933

Chromatin-remodelling complex, RSC SWI/SNF subunit Rsc7/Swp82

CRC_Rsc7/Swp82

Family

3,056

false

This entry contains subunits of the chromatin remodelling complexes. Saccharomyces cerevisiae (Baker's yeast) and its paralogue have been identified as subunits of the RSC chromatin remodelling complex, and SWI/SNF chromatin remodelling complex respectively [ ].

[]

0

[ "PFAM" ]

[ "PF08624" ]

[ "CRC_subunit" ]

[ 3056 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-SCE-4551638", "R-SCE-9764725", "R-SPO-4551638", "R-SPO-9764725" ]

[ "REACTOME:R-SCE-4551638", "REACTOME:R-SCE-9764725", "REACTOME:R-SPO-4551638", "REACTOME:R-SPO-9764725" ]

4

[ "6k15", "6kw3", "6kw4", "6kw5", "6tda", "6v8o", "6v92", "7c4j", "7egm", "7egp" ]

10

[ "PUB00033276" ]

[ "16204215" ]

[ "The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3056 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 2, 2 ]

3

true

Family

Chromatin-remodelling complex, RSC SWI/SNF subunit Rsc7/Swp82

CRC_Rsc7/Swp82

3

IPR013934

13,934

U3 small nucleolar RNA-associated protein 13, C-terminal

Utp13_C

Domain

4,821

false

A large ribonuclear protein complex is required for the processing of the small-ribosomal-subunit rRNA -the small-subunit (SSU) processome [ , ]. This preribosomal complex contains the U3 snoRNA and at least 40 proteins, which have the following properties: They are nucleolar. They are able to coimmunoprecipitate with ...

[ "GO:0006364", "GO:0032040" ]

[ "rRNA processing", "small-subunit processome" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08625" ]

[ "Utp13" ]

[ 4821 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

6

[ "5ic9", "5ica", "5oql", "5wlc", "5wyj", "5wyk", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqt", "6lqu", "6lqv", "6nd4", "6rxt", "6rxu", "6rxv", "6rxx", "6rxy", "6rxz", "6zqa", "6zqb", "6zqc", "6zqd", "6zqe", "6zqf", "7ajt", "7aju", "7d4i", "7d5s", "7d5t"...

50

[ "PUB00008496", "PUB00033340", "PUB00035836", "PUB00035837", "PUB00100831" ]

[ "12068309", "15231838", "15590835", "15489292", "17616738" ]

[ "A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.", "Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particle.", "The small-subunit processome is a ribosome assembly intermediate.", "RNA polymerase I transcription a...

[ 2002, 2004, 2004, 2004, 2007 ]

5

[]

0

null

[ "Eukaryota", "marine sediment metagenome" ]

[ 4820, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 2, 1, 3, 4, 1, 2, 3, 1, 1, 15 ]

12

true

Domain

U3 small nucleolar RNA-associated protein 13, C-terminal

Utp13_C

8

IPR013935

13,935

Trs120/TRAPPC9

Trs120_TRAPPC9

Family

6,477

false

This protein family includes Saccharomyces cerevisiae Trafficking protein particle complex II-specific subunit 120 (Trs120), human Trafficking protein particle complex subunit 9 (TRAPPC9) and similar eukaryotic proteins. Trs120 is a subunit specific to the TRAPP II complex [ ] along with Trs65p and Trs130p(TRAPPC10). I...

[]

0

[ "PANTHER" ]

[ "PTHR21512" ]

[ "" ]

[ 6477 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-204005", "R-DME-8876198", "R-HSA-204005", "R-HSA-8876198", "R-MMU-204005", "R-MMU-8876198", "R-SCE-204005", "R-SCE-8876198", "R-SPO-204005", "R-SPO-8876198" ]

[ "REACTOME:R-DME-204005", "REACTOME:R-DME-8876198", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-8876198", "REACTOME:R-SCE-204005", "REACTOME:R-SCE-8876198", "REACTOME:R-SPO-204005", "REACTOME:R-SPO-8876198" ]

10

[ "7e2c", "7e2d", "7e8s", "7e8t", "7e93", "7e94", "7ea3", "7u05", "7u06" ]

9

[ "PUB00033337", "PUB00055557", "PUB00055564", "PUB00055565", "PUB00143360", "PUB00161601" ]

[ "10727015", "11239471", "17041589", "18801063", "15951441", "20004763" ]

[ "Identification and characterization of five new subunits of TRAPP.", "TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport.", "TRAPPII subunits are required for the specificity switch of a Ypt-Rab GEF.", "The TRAPP complex: insights into its architecture and function.", "NIBP, a nove...

[ 2000, 2001, 2006, 2008, 2005, 2009 ]

6

[]

0

null

[ "Eukaryota" ]

[ 6477 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 3, 2, 3, 3, 1, 2, 7, 1, 1, 14 ]

12

true

Family

Trs120/TRAPPC9

Trs120_TRAPPC9

1

IPR013936

13,936

Chloroquine-resistance transporter-like

CRT-like

Family

3,158

false

This family represents the Plasmodium falciparum chloroquine resistance transporter (CRT) and homologous proteins. CRT regulates other transporters, like Na-H antiporter or nonselective cation transporters [ ]. The Arabidopsis homologues are involved in thiol transport from the plastid to the cytosol, playing a signifi...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08627", "PTHR31326" ]

[ "CRT-like", "" ]

[ 2957, 2680 ]

2

[]

0

[ "6ukj" ]

1

[ "PUB00073577", "PUB00073578", "PUB00095654" ]

[ "15258157", "15883156", "20080670" ]

[ "Evidence for activation of endogenous transporters in Xenopus laevis oocytes expressing the Plasmodium falciparum chloroquine resistance transporter, PfCRT.", "Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum tra...

[ 2004, 2005, 2010 ]

3

[]

[ "IPR017258" ]

0

1

0

[ "Clostridium mobile", "Eukaryota", "Mimiviridae", "marine metagenome" ]

[ 1, 3151, 5, 1 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 26, 8, 30 ]

3

true

Family

Chloroquine-resistance transporter-like

CRT-like

5

IPR013937

13,937

Sorting nexin, C-terminal

Sorting_nexin_C

Domain

12,880

false

This region is found at the C terminus of proteins belonging to the nexin family. It is found on proteins which also contain .

[]

0

[ "PFAM" ]

[ "PF08628" ]

[ "Nexin_C" ]

[ 12880 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 12880 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 4, 20, 2, 49, 17, 2, 6, 25, 1, 1, 16 ]

12

true

Domain

Sorting nexin, C-terminal

Sorting_nexin_C

1

IPR013938

13,938

Phosphodiesterase 8, N-terminal domain

PDE8_N

Domain

1,579

false

This region is found at the N terminus of members of PDE8 phosphodiesterase family [ ]. Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes [ ]. The cyclic nucleotide phosphodiesterases (PDE) comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and...

[]

0

[ "PFAM" ]

[ "PF08629" ]

[ "PDE8" ]

[ 1579 ]

1

[ "EC", "REACTOME", "REACTOME" ]

[ "3.1.4.53", "R-HSA-418555", "R-MMU-418555" ]

[ "EC:3.1.4.53", "REACTOME:R-HSA-418555", "REACTOME:R-MMU-418555" ]

3

[]

0

[ "PUB00033309", "PUB00043423", "PUB00043424", "PUB00043425", "PUB00043426", "PUB00154469" ]

[ "9784418", "18447606", "18367027", "18436153", "16696947", "34170501" ]

[ "Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase.", "Roflumilast: an oral, once-daily selective PDE-4 inhibitor for the management of COPD and asthma.", "Phosphodiesterase 5 inhibition in essential hypertension.", "Type 3 pho...

[ 1998, 2008, 2008, 2008, 2006, 2022 ]

6

[]

0

null

[ "Eumetazoa" ]

[ 1579 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 4, 8, 9 ]

4

true

Domain

Phosphodiesterase 8, N-terminal domain

PDE8_N

5

IPR013941

13,941

Protein Zds1, C-terminal

ZDS1_C

Domain

1,866

false

This region of the Zds1 protein is critical for sporulation and has also been shown to suppress the calcium sensitivity of Zds1 deletions [ ]. The C-terminal motif is common to both Zds1 and Zds2 proteins, both of which are putative interactors of Cdc55 and are required for the completion of mitotic exit and cytokinesi...

[]

0

[ "PFAM", "SMART" ]

[ "PF08632", "SM01327" ]

[ "Zds_C", "Zds_C" ]

[ 1866, 1861 ]

2

[]

0

[]

0

[ "PUB00033343", "PUB00055959" ]

[ "16322512", "18762578" ]

[ "zds1, a novel gene encoding an ortholog of Zds1 and Zds2, controls sexual differentiation, cell wall integrity and cell morphology in fission yeast.", "Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase." ]

[ 2006, 2008 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1866 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 1 ]

3

true

Domain

Protein Zds1, C-terminal

ZDS1_C

4

IPR013942

13,942

Mediator complex, subunit Med19, fungi

Mediator_Med19_fun

Family

1,481

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF08633", "PTHR28270" ]

[ "Rox3", "" ]

[ 1224, 535 ]

2

[]

0

[ "5n9j", "5oqm", "7ui9", "7uif", "7uig", "7uio", "8cen", "8ceo" ]

8

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 1481 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Mediator complex, subunit Med19, fungi

Mediator_Med19_fun

3

IPR013943

13,943

Mitochondrial protein Pet127

Pet127

Family

1,810

false

This entry represents a group of fungal mitochondria proteins, known as Pet127, that stimulate mitochondrial RNA degradation [ , ]. Pet127 has been classified as part of the PD-(D/E)XK nuclease superfamily including a full set of active site residues [ ].

[ "GO:0000959", "GO:0005739" ]

[ "mitochondrial RNA metabolic process", "mitochondrion" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF08634", "PTHR31014" ]

[ "Pet127", "" ]

[ 1795, 1802 ]

2

[]

0

[]

0

[ "PUB00033310", "PUB00078894", "PUB00078895" ]

[ "9111353", "17292401", "20529888" ]

[ "Pet127p, a membrane-associated protein involved in stability and processing of Saccharomyces cerevisiae mitochondrial RNAs.", "RNA degradation in fission yeast mitochondria is stimulated by a member of a new family of proteins that are conserved in lower eukaryotes.", "COMA server for protein distant homology ...

[ 1997, 2007, 2010 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1810 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Mitochondrial protein Pet127

Pet127

8

IPR013944

13,944

Oxidoreductase putative, C-terminal

OxRdtase_put_C

Domain

703

false

This is the C terminus of putative oxidoreductases.

[]

0

[ "PFAM" ]

[ "PF08635" ]

[ "ox_reductase_C" ]

[ 703 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "marine sediment metagenome" ]

[ 702, 1 ]

2

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2 ]

1

true

Domain

Oxidoreductase putative, C-terminal

OxRdtase_put_C

9

IPR013945

13,945

V-type ATPase assembly factor Pkr1

Pkr1

Family

1,720

false

Pkr1 functions together with the other V-type ATPase assembly factors in the endoplasmic reticulum to efficiently assemble the V-type ATPase membrane sector V0 [ ].

[ "GO:0070072" ]

[ "vacuolar proton-transporting V-type ATPase complex assembly" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF08636", "PTHR28251" ]

[ "Pkr1", "" ]

[ 1714, 1485 ]

2

[]

0

[]

0

[ "PUB00077029" ]

[ "16926153" ]

[ "PKR1 encodes an assembly factor for the yeast V-type ATPase." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1720 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

V-type ATPase assembly factor Pkr1

Pkr1

2

IPR013946

13,946

NCA2-like

Family

2,965

false

NCA2 (Nuclear Control of ATPase), is one of the two nuclear genes involved in the control of mitochondrial expression of subunits 6 and 8 of the Fo-F1 ATP synthase in Saccharomyces cerevisiae. Mutations in either NCA2 or NCA3 ( ) dramatically lower the level of the co-transcript encoding subunits 6 and 8 [ , ]. This en...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08637", "PTHR28234" ]

[ "NCA2", "" ]

[ 2904, 2884 ]

2

[]

0

[]

0

[ "PUB00033300", "PUB00033357", "PUB00078614" ]

[ "7723016", "7586026", "20181751" ]

[ "NCA2, a second nuclear gene required for the control of mitochondrial synthesis of subunits 6 and 8 of ATP synthase in Saccharomyces cerevisiae.", "NCA3, a nuclear gene involved in the mitochondrial expression of subunits 6 and 8 of the Fo-F1 ATP synthase of S. cerevisiae.", "Phosphate regulation of lipid bios...

[ 1995, 1995, 2010 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 2963 ]

2

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 1, 13, 1, 1, 8 ]

6

true

Family

NCA2-like

4

IPR013947

13,947

Mediator complex, subunit Med14

Mediator_Med14

Family

5,532

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PANTHER" ]

[ "PTHR12809" ]

[ "" ]

[ 5532 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-9841922", "R-HSA-1989781", "R-HSA-212436", "R-HSA-381340", "R-HSA-9833110", "R-HSA-9841922" ]

[ "REACTOME:R-DME-9841922", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-212436", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9841922" ]

6

[ "5n9j", "5oqm", "5u0p", "5u0s", "6w1s", "6xp5", "7emf", "7ena", "7enc", "7enj", "7jmn", "7lbm", "7nvr", "7ui9", "7uic", "7uif", "7uig", "7uik", "7uil", "7uio", "8cen", "8ceo", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw", "8trh" ]

29

[ "PUB00033293", "PUB00033294", "PUB00033372" ]

[ "7851756", "7635307", "15175151" ]

[ "Requirement for RGR1 and SIN4 in RME1-dependent repression in Saccharomyces cerevisiae.", "Genetic and physical interactions between yeast RGR1 and SIN4 in chromatin organization and transcriptional regulation.", "A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulat...

[ 1994, 1995, 2004 ]

3

[]

0

null

[ "Eukaryota" ]

[ 5532 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 3, 3, 5, 3, 1, 10, 8, 1, 1, 18 ]

12

true

Family

Mediator complex, subunit Med14

Mediator_Med14

9

IPR013948

13,948

DNA replication regulator Sld3, C-terminal

DNA_replication_reg_Sld3_C

Domain

1,485

false

The Sld3 DNA replication regulator is required for loading and maintenance of Cdc45 on chromatin during DNA replication [ ]. This entry represents the C-terminal domain of Sld3 which includes the Sld3-Treslin domain (STD), essential for replication origin firing [ , , ]. This domain consists of two segments with 12 hel...

[]

0

[ "PFAM" ]

[ "PF08639" ]

[ "Sld3_STD" ]

[ 1485 ]

1

[]

0

[ "3wi3", "8j09" ]

2

[ "PUB00033328", "PUB00103954", "PUB00103961", "PUB00103962" ]

[ "12006645", "35091422", "25126958", "22380713" ]

[ "SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in DNA replication in fission yeast.", "Refining the domain architecture model of the replication origin firing factor Treslin/TICRR.", "Crystal structure of the homology domain of the eukaryotic DNA replication proteins Sld3/Treslin.", "...

[ 2002, 2022, 2014, 2012 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1485 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

DNA replication regulator Sld3, C-terminal

DNA_replication_reg_Sld3_C

5

IPR013949

13,949

U3 small nucleolar RNA-associated protein 6

Utp6

Family

5,006

false

Utp6 is a component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [ ].

[ "GO:0030515", "GO:0000462" ]

[ "snoRNA binding", "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER" ]

[ "PTHR23271" ]

[ "" ]

[ 5006 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6791226", "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-DDI-6791226", "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

6

[ "5ic8", "5oql", "5wlc", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqt", "6lqu", "6lqv", "6nd4", "6rxt", "6rxu", "6rxv", "6rxx", "6rxy", "6rxz", "6zqa", "6zqb", "6zqc", "6zqd", "7ajt", "7aju", "7d4i", "7d5s", "7d5t", "7d63", "7mq8", "7mq9", "7mqa", "7suk"...

44

[ "PUB00008496" ]

[ "12068309" ]

[ "A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5006 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 5, 3, 6, 6, 3, 1, 4, 4, 1, 1, 7 ]

11

true

Family

U3 small nucleolar RNA-associated protein 6

Utp6

2

IPR013950

13,950

Kinetochore Mis14/Nsl1

Mis14/Nsl1

Family

2,516

false

This entry includes Mis14 from S. pombe, Nsl1 from S. cerevisiae and Nsl1 homologues from animals. MIs14 is a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle [ ]. Nsl1 is an essential component of the kineto...

[ "GO:0000070", "GO:0000776" ]

[ "mitotic sister chromatid segregation", "kinetochore" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF08641", "PTHR31749" ]

[ "Mis14", "" ]

[ 2427, 2285 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-68877", "R-MMU-9648025" ]

[ "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2500257", "REACTOME:R-MMU-5663220", "REACTOME:R-MMU-68877", "REACTOME:R-MM...

12

[ "5lsi", "5lsj", "5lsk", "5t58", "8ppr", "8q5h" ]

6

[ "PUB00019931", "PUB00033296" ]

[ "14633972", "15369671" ]

[ "Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes.", "Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres." ]

[ 2003, 2004 ]

2

[]

0

null

[ "Eukaryota", "Methanosarcinaceae" ]

[ 2512, 4 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 6, 5, 1, 3, 1, 1 ]

7

true

Family

Kinetochore Mis14/Nsl1

Mis14/Nsl1

5

IPR013951

13,951

Histone deacetylation protein Rxt3

Rxt3

Family

2,394

false

Rxt3 is a component of the Rpd3L histone deacetylase complex that is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) [ ].

[]

0

[ "PFAM" ]

[ "PF08642" ]

[ "Rxt3" ]

[ 2394 ]

1

[]

0

[ "8ga8", "8hpo", "8i03" ]

3

[ "PUB00033324" ]

[ "16314178" ]

[ "Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2394 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 6, 1, 3, 1, 1, 13 ]

6

true

Family

Histone deacetylation protein Rxt3

Rxt3

4

IPR013952

13,952

Protein of unknown function DUF1776, fungi

DUF1776_fun

Family

1,416

false

This is a fungal protein of unknown function. One of the proteins has been localised to the mitochondria [ ].

[]

0

[ "PFAM" ]

[ "PF08643" ]

[ "DUF1776" ]

[ 1416 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-SPO-193144", "R-SPO-194002", "R-SPO-5365859", "R-SPO-77108", "R-SPO-77111", "R-SPO-9757110" ]

[ "REACTOME:R-SPO-193144", "REACTOME:R-SPO-194002", "REACTOME:R-SPO-5365859", "REACTOME:R-SPO-77108", "REACTOME:R-SPO-77111", "REACTOME:R-SPO-9757110" ]

6

[]

0

[ "PUB00033287" ]

[ "14576278" ]

[ "The proteome of Saccharomyces cerevisiae mitochondria." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1416 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Protein of unknown function DUF1776, fungi

DUF1776_fun

2

IPR013953

13,953

FACT complex subunit SPT16, middle domain

FACT_SPT16_M

Domain

5,036

false

This entry represents a domain found in the central region of Spt16 from diverse eukaryotes [ , ]. This entry covers the dimerization domain (DD), which straddles nucleosomal DNA at the H2A-H2B dyad [ ]. SPT16 is a component of the FACT (facilitator of chromatin transcription) complex, a general chromatin factor that a...

[]

0

[ "PFAM", "SMART" ]

[ "PF08644", "SM01286" ]

[ "SPT16", "SPT16" ]

[ 4992, 4999 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-112382", "R-CEL-674695", "R-CEL-6796648", "R-CEL-6804756", "R-CEL-75955", "R-DDI-674695", "R-DDI-6796648", "R-DDI-6804756", "R-DME-112382", "R-DME-674695", "R-DME-6796648", "R-DME-6804756", "R-DME-75955", "R-HSA-112382", "R-HSA-167152", "R-HSA-167200", "R-HSA-167238", "R-HSA...

[ "REACTOME:R-CEL-112382", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-6796648", "REACTOME:R-CEL-6804756", "REACTOME:R-CEL-75955", "REACTOME:R-DDI-674695", "REACTOME:R-DDI-6796648", "REACTOME:R-DDI-6804756", "REACTOME:R-DME-112382", "REACTOME:R-DME-674695", "REACTOME:R-DME-6796648", "REACTOME:R-DME...

36

[ "4kha", "4khb", "4kho", "4z2m", "4z2n", "6upk", "6upl", "7nky", "7xsx", "7xt7", "7xtd", "7xti", "8xgc", "8yjf", "8yjm", "9eh2", "9gw2", "9rzc", "9s0u", "9s3g" ]

20

[ "PUB00033331", "PUB00033373", "PUB00033374", "PUB00070237", "PUB00070238", "PUB00101031", "PUB00101032", "PUB00101034" ]

[ "15987999", "12524332", "12934006", "12815073", "10413469", "21454601", "31775157", "33846633" ]

[ "The yeast FACT complex has a role in transcriptional initiation.", "Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.", "FACT facilitates transcription-dependent nucleosome alteration.", "Drosophila FACT c...

[ 2005, 2002, 2003, 2003, 1999, 2011, 2020, 2021 ]

8

[]

0

null

[ "Eukaryota" ]

[ 5036 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 3, 1, 1, 2, 1, 6, 3, 1, 1, 3 ]

12

true

Domain

FACT complex subunit SPT16, middle domain

FACT_SPT16_M

8

IPR013954

13,954

Polynucleotide kinase 3 phosphatase

PNK3P

Family

7,027

false

Polynucleotide kinase 3 phosphatases play a role in the repair of single breaks in DNA induced by DNA-damaging agents such as gamma radiation and camptothecin [ ].

[]

0

[ "PFAM" ]

[ "PF08645" ]

[ "PNK3P" ]

[ 7027 ]

1

[ "EC", "REACTOME", "REACTOME" ]

[ "3.1.3", "R-HSA-5649702", "R-MMU-5649702" ]

[ "EC:3.1.3", "REACTOME:R-HSA-5649702", "REACTOME:R-MMU-5649702" ]

3

[ "1yj5", "2fpr", "2fps", "2fpu", "2fpw", "2fpx", "3u7e", "3u7f", "3u7g", "3u7h", "3zvl", "3zvm", "3zvn" ]

13

[ "PUB00033313" ]

[ "11729194" ]

[ "Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe." ]

[ 2002 ]

1

[]

[ "IPR006550" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 16, 1784, 5026, 106, 95 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 3, 2, 8, 7, 1, 5, 5, 1, 1, 12 ]

12

true

Family

Polynucleotide kinase 3 phosphatase

PNK3P

5

IPR013955

13,955

Replication factor A, C-terminal

Rep_factor-A_C

Domain

16,230

false

Replication factor A (RP-A) binds and subsequently stabilises single-stranded DNA intermediates and thus prevents complementary DNA from reannealing. It also plays an essential role in several cellular processes in DNA metabolism including replication, recombination and repair of DNA [ , ]. Replication factor-A protein...

[]

0

[ "PFAM" ]

[ "PF08646" ]

[ "Rep_fac-A_C" ]

[ 16230 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-110312", "R-CEL-110314", "R-CEL-110320", "R-CEL-176187", "R-CEL-5651801", "R-CEL-5655862", "R-CEL-5656121", "R-CEL-5656169", "R-CEL-5693607", "R-CEL-5696397", "R-CEL-5696400", "R-CEL-6782135", "R-CEL-6782210", "R-CEL-68962", "R-CEL-69166", "R-DME-110312", "R-DME-110314", "R-...

[ "REACTOME:R-CEL-110312", "REACTOME:R-CEL-110314", "REACTOME:R-CEL-110320", "REACTOME:R-CEL-176187", "REACTOME:R-CEL-5651801", "REACTOME:R-CEL-5655862", "REACTOME:R-CEL-5656121", "REACTOME:R-CEL-5656169", "REACTOME:R-CEL-5693607", "REACTOME:R-CEL-5696397", "REACTOME:R-CEL-5696400", "REACTOME:R-...

175

[ "1l1o", "3u50", "4gnx", "4gop", "6d6v", "6i52", "7lma", "7lmb", "7uy5", "7uy6", "8aaj", "8aas", "8c5y", "8c5z", "8gap", "8oej", "8oel", "8rk2", "9mj5" ]

19

[ "PUB00022049", "PUB00033318" ]

[ "11927569", "10713540" ]

[ "Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA.", "Study of interaction of human replication factor A with DNA using new photoreactive analogs of dTTP." ]

[ 2002, 2000 ]

2

[]

[ "IPR047192" ]

0

1

0

[ "Archaea", "Eukaryota", "ecological metagenomes" ]

[ 137, 16083, 10 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 52, 1, 2, 1, 7, 7, 1, 19, 7, 1, 1, 93 ]

12

true

Domain

Replication factor A, C-terminal

Rep_factor-A_C

4

IPR013957

13,957

U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein

SNRNP27

Domain

3,768

false

U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein may play a role in mRNA splicing [ ].

[ "GO:0008380" ]

[ "RNA splicing" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08648" ]

[ "SNRNP27" ]

[ 3768 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163" ]

2

[ "6qw6", "6qx9", "8h6e", "8h6j", "8qp8", "8qp9", "8qpk", "8qxd", "8r08", "8r0a" ]

10

[ "PUB00084347" ]

[ "9085842" ]

[ "The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase." ]

[ 1997 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3768 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 5, 1, 1, 2, 4, 1, 1, 10, 3, 1, 4 ]

11

true

Domain

U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein

SNRNP27

9

IPR013958

13,958

DASH complex subunit Dad1

DASH_Dad1

Family

1,547

false

The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [ ]. In Saccharomyces cerevisiae (Baker's yeast) DASH forms both rings and spiral structures on microtubules in vitro [ , ]. Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, a...

[ "GO:0042729", "GO:0072686" ]

[ "DASH complex", "mitotic spindle" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF08649", "PTHR28025" ]

[ "DASH_Dad1", "" ]

[ 1529, 1432 ]

2

[]

0

[ "6cfz", "8q84", "8q85" ]

3

[ "PUB00017174", "PUB00033281", "PUB00033282", "PUB00033283", "PUB00033284" ]

[ "11799062", "15640796", "15664196", "15632076", "16079915" ]

[ "The mitotic spindle is required for loading of the DASH complex onto the kinetochore.", "The yeast DASH complex forms closed rings on microtubules.", "Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex.", "Genetic analysis of the kinetochore DASH complex revea...

[ 2002, 2005, 2005, 2005, 2005 ]

5

[]

0

null

[ "Eukaryota" ]

[ 1547 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

DASH complex subunit Dad1

DASH_Dad1

8

IPR013960

13,960

DASH complex subunit Duo1

DASH_Duo1

Family

1,646

false

The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [ ]. In Saccharomyces cerevisiae (Baker's yeast) DASH forms both rings and spiral structures on microtubules in vitro [ , ].

[ "GO:0000278", "GO:0042729", "GO:0072686" ]

[ "mitotic cell cycle", "DASH complex", "mitotic spindle" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF08651", "PTHR28216" ]

[ "DASH_Duo1", "" ]

[ 1641, 1555 ]

2

[]

0

[ "6cfz", "8q84", "8q85" ]

3

[ "PUB00017174", "PUB00033281", "PUB00033282" ]

[ "11799062", "15640796", "15664196" ]

[ "The mitotic spindle is required for loading of the DASH complex onto the kinetochore.", "The yeast DASH complex forms closed rings on microtubules.", "Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex." ]

[ 2002, 2005, 2005 ]

3

[]

0

null

[ "Opisthokonta", "Paraflavitalea soli" ]

[ 1645, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

DASH complex subunit Duo1

DASH_Duo1

5

IPR013961

13,961

RAI1-like

RAI1

Domain

5,097

false

Yeast RAI1 is homologous to Caenorhabditis elegans DOM-3 and human DOM3Z (DXO). They have both decapping and 5'-3' exoribonuclease activity and are a component of the mRNA 5'-end capping quality control mechanism [ , ]. RAI1 is a single-copy gene in most organisms; however S. cerevisiae contains a second homologue, DXO...

[]

0

[ "PFAM" ]

[ "PF08652" ]

[ "RAI1" ]

[ 5097 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME" ]

[ "3.6.1.-", "PWY-5757", "PWY-6147", "PWY-6383", "PWY-6797", "PWY-7206", "PWY-7419", "PWY-7539", "PWY-7719", "PWY-7821", "PWY-8289", "R-HSA-9930044" ]

[ "EC:3.6.1.-", "METACYC:PWY-5757", "METACYC:PWY-6147", "METACYC:PWY-6383", "METACYC:PWY-6797", "METACYC:PWY-7206", "METACYC:PWY-7419", "METACYC:PWY-7539", "METACYC:PWY-7719", "METACYC:PWY-7821", "METACYC:PWY-8289", "REACTOME:R-HSA-9930044" ]

12

[ "3fqd", "3fqg", "3fqi", "3fqj", "4gps", "4gpu", "4j7l", "4j7m", "4j7n", "5btb", "5bte", "5bth", "5bto", "5bud", "5uli", "5ulj", "6aix", "6aiy", "6dkn", "6wre", "6wuf", "6wug", "6wui", "6wuk", "8jch", "8k5p", "8q6v", "8yf5", "8yfe", "8yfq", "8yfr", "9dso"...

34

[ "PUB00065830", "PUB00088803", "PUB00095665" ]

[ "22961381", "26101253", "30949699" ]

[ "Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity.", "Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes.", "Arabidopsis DXO1 links RNA turnover and chloroplast function independently of its enzymatic activity." ]

[ 2012, 2015, 2019 ]

3

[]

0

null

[ "Eukaryota" ]

[ 5097 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 8, 1, 10, 6, 8, 1, 4, 5, 2, 1, 7 ]

12

true

Domain

RAI1-like

RAI1

7

IPR013962

13,962

DASH complex subunit Dam1

DASH_Dam1

Family

1,663

false

The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [ ]. In Saccharomyces cerevisiae (Baker's yeast) DASH forms both rings and spiral structures on microtubules in vitro [ , ]. Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, a...

[ "GO:0008608", "GO:0042729", "GO:0072686" ]

[ "attachment of spindle microtubules to kinetochore", "DASH complex", "mitotic spindle" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF08653", "PTHR28113" ]

[ "DASH_Dam1", "" ]

[ 1662, 1519 ]

2

[]

0

[ "6cfz", "8q84", "8q85", "8qau" ]

4

[ "PUB00017174", "PUB00033281", "PUB00033282", "PUB00033283", "PUB00033284" ]

[ "11799062", "15640796", "15664196", "15632076", "16079915" ]

[ "The mitotic spindle is required for loading of the DASH complex onto the kinetochore.", "The yeast DASH complex forms closed rings on microtubules.", "Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex.", "Genetic analysis of the kinetochore DASH complex revea...

[ 2002, 2005, 2005, 2005, 2005 ]

5

[]

0

null

[ "Eukaryota" ]

[ 1663 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

DASH complex subunit Dam1

DASH_Dam1

7

IPR013963

13,963

DASH complex subunit Dad2

DASH_Dad2

Family

1,592

false

The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [ ]. In Saccharomyces cerevisiae (Baker's yeast) DASH forms both rings and spiral structures on microtubules in vitro [ , ].

[ "GO:0000278", "GO:0042729", "GO:0072686" ]

[ "mitotic cell cycle", "DASH complex", "mitotic spindle" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF08654", "PTHR28036" ]

[ "DASH_Dad2", "" ]

[ 1587, 1463 ]

2

[]

0

[ "6cfz", "8q84", "8q85" ]

3

[ "PUB00017174", "PUB00033281", "PUB00033282" ]

[ "11799062", "15640796", "15664196" ]

[ "The mitotic spindle is required for loading of the DASH complex onto the kinetochore.", "The yeast DASH complex forms closed rings on microtubules.", "Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex." ]

[ 2002, 2005, 2005 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1592 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

DASH complex subunit Dad2

DASH_Dad2

2

IPR013964

13,964

DASH complex subunit Ask1

DASH_Ask1

Family

1,770

false

The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [ ]. In Saccharomyces cerevisiae (Baker's yeast) DASH forms both rings and spiral structures on microtubules in vitro [ , ]. Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, a...

[ "GO:0008608", "GO:0042729", "GO:0072686" ]

[ "attachment of spindle microtubules to kinetochore", "DASH complex", "mitotic spindle" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF08655", "PTHR28200" ]

[ "DASH_Ask1", "" ]

[ 1704, 1658 ]

2

[]

0

[ "6cfz", "8q84", "8q85" ]

3

[ "PUB00017174", "PUB00033281", "PUB00033282", "PUB00033283" ]

[ "11799062", "15640796", "15664196", "15632076" ]

[ "The mitotic spindle is required for loading of the DASH complex onto the kinetochore.", "The yeast DASH complex forms closed rings on microtubules.", "Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex.", "Genetic analysis of the kinetochore DASH complex revea...

[ 2002, 2005, 2005, 2005 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 1768 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

DASH complex subunit Ask1

DASH_Ask1

5

IPR013965

13,965

DASH complex subunit Dad3

DASH_Dad3

Family

1,503

false

The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [ ]. In Saccharomyces cerevisiae (Baker's yeast) DASH forms both rings and spiral structures on microtubules in vitro [ , ].

[ "GO:0008608", "GO:0042729", "GO:0072686" ]

[ "attachment of spindle microtubules to kinetochore", "DASH complex", "mitotic spindle" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF08656", "PTHR28017" ]

[ "DASH_Dad3", "" ]

[ 1500, 1431 ]

2

[]

0

[ "6cfz", "8q84", "8q85" ]

3

[ "PUB00017174", "PUB00033281", "PUB00033282" ]

[ "11799062", "15640796", "15664196" ]

[ "The mitotic spindle is required for loading of the DASH complex onto the kinetochore.", "The yeast DASH complex forms closed rings on microtubules.", "Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex." ]

[ 2002, 2005, 2005 ]

3

[]

0

null

[ "Eukaryota", "Hyphantria cunea granulovirus" ]

[ 1502, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

DASH complex subunit Dad3

DASH_Dad3

5

IPR013966

13,966

DASH complex subunit Spc34

Spc34

Family

1,189

false

The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [ ]. In Saccharomyces cerevisiae (Baker's yeast) DASH forms both rings and spiral structures on microtubules in vitro [ , ]. Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, a...

[ "GO:0008608", "GO:0005876", "GO:0042729" ]

[ "attachment of spindle microtubules to kinetochore", "spindle microtubule", "DASH complex" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM" ]

[ "PF08657" ]

[ "DASH_Spc34" ]

[ 1189 ]

1

[]

0

[ "6cfz", "8q84", "8q85" ]

3

[ "PUB00017174", "PUB00033281", "PUB00033282", "PUB00033283" ]

[ "11799062", "15640796", "15664196", "15632076" ]

[ "The mitotic spindle is required for loading of the DASH complex onto the kinetochore.", "The yeast DASH complex forms closed rings on microtubules.", "Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex.", "Genetic analysis of the kinetochore DASH complex revea...

[ 2002, 2005, 2005, 2005 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1189 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

DASH complex subunit Spc34

Spc34

5

IPR013968

13,968

Polyketide synthase-like, ketoreductase domain

PKS_KR

Domain

59,690

false

This entry represents the ketoreductase domain in polyketides synthase-like and fatty acid related enzymes in fungi and bacteria. The ketoreductase (KR) domain is a conserved catalytic domain that belongs to the short-chain dehydrogenase/reductase (SDR) superfamily and contains a Rossmann fold, which is crucial for bin...

[]

0

[ "PFAM" ]

[ "PF08659" ]

[ "KR" ]

[ 59690 ]

1

[ "EC", "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METAC...

[ "2.3.1", "2.3.1.-", "GenProp1220", "PWY-3602", "PWY-361", "PWY-4801", "PWY-4922", "PWY-5048", "PWY-5139", "PWY-5268", "PWY-5284", "PWY-5292", "PWY-5307", "PWY-5313", "PWY-5317", "PWY-5318", "PWY-5353", "PWY-5400", "PWY-5473", "PWY-5475", "PWY-5477", "PWY-5660", "PWY-5679"...

[ "EC:2.3.1", "EC:2.3.1.-", "GP:GenProp1220", "METACYC:PWY-3602", "METACYC:PWY-361", "METACYC:PWY-4801", "METACYC:PWY-4922", "METACYC:PWY-5048", "METACYC:PWY-5139", "METACYC:PWY-5268", "METACYC:PWY-5284", "METACYC:PWY-5292", "METACYC:PWY-5307", "METACYC:PWY-5313", "METACYC:PWY-5317", "ME...

233

[ "2fr0", "2fr1", "2vz8", "2vz9", "2z5l", "3mjc", "3mje", "3mjs", "3mjt", "3mjv", "3qp9", "3slk", "4dif", "4hxy", "4imp", "4j1q", "4j1s", "4l4x", "4piv", "5bp4", "5c37", "5d2e", "5ktk", "5xwv", "5xww", "6fn6", "6nna", "6ulw", "6w7s", "6wh9", "7cpx", "7cpy"...

79

[ "PUB00040785", "PUB00071551", "PUB00160320", "PUB00160321", "PUB00160322", "PUB00160324", "PUB00160325", "PUB00160326" ]

[ "16564177", "23790488", "1595878", "18663394", "26689670", "26863427", "27118242", "18723688" ]

[ "The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.", "Structural and stereochemical analysis of a modular polyketide synthase ketoreductase domain required for the generation of a cis-alkene.", "Understanding pulse oximetry.", "...

[ 2006, 2013, 1992, 2008, 2016, 2016, 2016, 2008 ]

8

[ "IPR057326" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 5, 35622, 23998, 65 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 3, 9, 10, 2, 6, 6, 5 ]

8

true

Domain

Polyketide synthase-like, ketoreductase domain

PKS_KR

7

IPR013969

13,969

Oligosaccharide biosynthesis protein Alg14-like

Oligosacch_biosynth_Alg14

Family

6,154

false

Alg14 is involved dolichol-linked oligosaccharide biosynthesis and anchors the catalytic subunit Alg13 to the ER membrane [ ].

[ "GO:0006488" ]

[ "dolichol-linked oligosaccharide biosynthetic process" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF08660", "PTHR12154" ]

[ "Alg14", "" ]

[ 6149, 5657 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-446193", "R-HSA-5633231", "R-MMU-446193", "R-RNO-446193", "R-SPO-446193" ]

[ "REACTOME:R-HSA-446193", "REACTOME:R-HSA-5633231", "REACTOME:R-MMU-446193", "REACTOME:R-RNO-446193", "REACTOME:R-SPO-446193" ]

5

[]

0

[ "PUB00033270" ]

[ "16100110" ]

[ "Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation." ]

[ 2005 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 41, 1583, 4514, 16 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 2, 1, 1, 1, 2, 1, 4, 5, 1, 1, 23 ]

12

true

Family

Oligosaccharide biosynthesis protein Alg14-like

Oligosacch_biosynth_Alg14

2

IPR013970

13,970

Replication factor A protein 3

Rfa2

Family

4,178

false

Rfa3 (also known as RPA14) is a component of the replication protein A (RPA) complex, which binds to and removes secondary structure from ssDNA. The RPA complex is involved in DNA replication, repair, and recombination [ ].

[ "GO:0003677", "GO:0006260", "GO:0006281", "GO:0006310", "GO:0005634" ]

[ "DNA binding", "DNA replication", "DNA repair", "DNA recombination", "nucleus" ]

[ "molecular_function", "biological_process", "biological_process", "biological_process", "cellular_component" ]

5

[ "PFAM" ]

[ "PF08661" ]

[ "Rep_fac-A_3" ]

[ 4178 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-110312", "R-HSA-110314", "R-HSA-110320", "R-HSA-174437", "R-HSA-176187", "R-HSA-3371453", "R-HSA-3371511", "R-HSA-5358565", "R-HSA-5358606", "R-HSA-5651801", "R-HSA-5655862", "R-HSA-5656121", "R-HSA-5656169", "R-HSA-5685938", "R-HSA-5685942", "R-HSA-5693607", "R-HSA-5693616", ...

[ "REACTOME:R-HSA-110312", "REACTOME:R-HSA-110314", "REACTOME:R-HSA-110320", "REACTOME:R-HSA-174437", "REACTOME:R-HSA-176187", "REACTOME:R-HSA-3371453", "REACTOME:R-HSA-3371511", "REACTOME:R-HSA-5358565", "REACTOME:R-HSA-5358606", "REACTOME:R-HSA-5651801", "REACTOME:R-HSA-5655862", "REACTOME:R-H...

73

[ "1l1o", "1quq", "2pi2", "2pqa", "2z6k", "3kdf", "4gnx", "4gop", "6d6v", "6i52", "7lma", "7lmb", "7uy5", "7uy6", "8gap", "8rk2", "9mj5" ]

17

[ "PUB00070983" ]

[ "20012581" ]

[ "Eukaryotic single-stranded DNA binding proteins: central factors in genome stability." ]

[ 2010 ]

1

[]

[ "IPR016588" ]

0

1

0

[ "Eukaryota", "Methanobacteriota" ]

[ 4173, 5 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 4, 1, 1, 3, 1, 1, 1, 3, 1, 1, 16 ]

11

true

Family

Replication factor A protein 3

Rfa2

2

IPR013971

13,971

HalX domain

HalX_domain

Domain

1,331

false

HalX domain protein is a protein of unknown function, previously mis-annotated as HoxA-like transcriptional regulator. The HalX domain is C-terminal to a CheY-like domain ( ), which suggests a role as a response regulator.

[]

0

[ "PFAM" ]

[ "PF08663" ]

[ "HalX" ]

[ 1331 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Eukaryota", "Streptomyces chrestomyceticus JCM 4735", "viral metagenome" ]

[ 1323, 6, 1, 1 ]

4

[]

0

true

Domain

HalX domain

HalX_domain

6