interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR015422 | 15,422 | Pyridoxal phosphate-dependent transferase, small domain | PyrdxlP-dep_Trfase_small | Homologous_superfamily | 1,057,631 | false | false | The monomer of PLP-dependent transferases consists of two domains, a large domain and a small domain. This entry represents small domain, which has a complex α/β structure [ ]. It can be found in the following PLP-dependent transferase families: Aspartate aminotransferase (AAT)-like enzymes, such as aromatic aminoacid ... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:3.90.1150.10"
] | [
""
] | [
1057631
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1483213",
"R-BTA-1660661",
"R-BTA-189451",
"R-BTA-196757",
"R-BTA-2408508",
"R-BTA-389661",
"R-BTA-70921",
"R-BTA-8963684",
"R-BTA-8963693",
"R-BTA-8964539",
"R-BTA-9013408",
"R-BTA-9837999",
"R-BTA-9856872",
"R-CEL-1442490",
"R-CEL-1483213",
"R-CEL-1614558",
"R-CEL-1614603",
... | [
"REACTOME:R-BTA-1483213",
"REACTOME:R-BTA-1660661",
"REACTOME:R-BTA-189451",
"REACTOME:R-BTA-196757",
"REACTOME:R-BTA-2408508",
"REACTOME:R-BTA-389661",
"REACTOME:R-BTA-70921",
"REACTOME:R-BTA-8963684",
"REACTOME:R-BTA-8963693",
"REACTOME:R-BTA-8964539",
"REACTOME:R-BTA-9013408",
"REACTOME:R-B... | 216 | [
"1aam",
"1aat",
"1aaw",
"1ahe",
"1ahf",
"1ahg",
"1ahx",
"1ahy",
"1aia",
"1aib",
"1aic",
"1ajr",
"1ajs",
"1aka",
"1akb",
"1akc",
"1ama",
"1amq",
"1amr",
"1ams",
"1arg",
"1arh",
"1ari",
"1ars",
"1art",
"1asa",
"1asb",
"1asc",
"1asd",
"1ase",
"1asf",
"1asg"... | 1,667 | [
"PUB00006322",
"PUB00014087",
"PUB00035504",
"PUB00035505",
"PUB00035506",
"PUB00035507",
"PUB00035508",
"PUB00035511",
"PUB00035512",
"PUB00035513",
"PUB00035514",
"PUB00035515",
"PUB00043268",
"PUB00153780",
"PUB00153781"
] | [
"7748903",
"10666573",
"15581583",
"8690703",
"15189147",
"17109392",
"16763894",
"17300176",
"16790938",
"15690345",
"17014820",
"15848278",
"17583737",
"20142041",
"36320885"
] | [
"Pyridoxal phosphate-dependent enzymes.",
"Three-dimensional structure of the Gly121Tyr dimeric form of ornithine decarboxylase from Lactobacillus 30a.",
"Reaction specificity in pyridoxal phosphate enzymes.",
"Pyridoxal enzymes: mechanistic diversity and uniformity.",
"Pyridoxal phosphate enzymes: mechanis... | [
1995,
1999,
2005,
1995,
2004,
2006,
2006,
2007,
2006,
2005,
2006,
2005,
2007,
2010,
2022
] | 15 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
18878,
802928,
218073,
220,
17532
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
367,
49,
98,
64,
36,
210,
117,
38,
263,
186,
30,
27,
580
] | 13 | true | Homologous_superfamily | Pyridoxal phosphate-dependent transferase, small domain | Pyridoxal phosphate-dependent transferase, small domain | PyrdxlP-dep_Trfase_small | 3 |
IPR015424 | 15,424 | Pyridoxal phosphate-dependent transferase | PyrdxlP-dep_Trfase | Homologous_superfamily | 1,222,161 | false | false | This entry represents the major region of PLP-dependent transferases. This domain has a three layer α/β/α sandwich topology, with mixed β-sheets of 7 strands. The major region can be found in the following PLP-dependent transferase families: Aspartate aminotransferase (AAT)-like enzymes, such as aromatic aminoacid amin... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF53383"
] | [
""
] | [
1222161
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1483213",
"R-BTA-1614558",
"R-BTA-1660661",
"R-BTA-189451",
"R-BTA-196757",
"R-BTA-2408508",
"R-BTA-389661",
"R-BTA-70921",
"R-BTA-888568",
"R-BTA-888590",
"R-BTA-8963684",
"R-BTA-8963693",
"R-BTA-8964539",
"R-BTA-9013408",
"R-BTA-947581",
"R-BTA-9837999",
"R-BTA-9856872",
"... | [
"REACTOME:R-BTA-1483213",
"REACTOME:R-BTA-1614558",
"REACTOME:R-BTA-1660661",
"REACTOME:R-BTA-189451",
"REACTOME:R-BTA-196757",
"REACTOME:R-BTA-2408508",
"REACTOME:R-BTA-389661",
"REACTOME:R-BTA-70921",
"REACTOME:R-BTA-888568",
"REACTOME:R-BTA-888590",
"REACTOME:R-BTA-8963684",
"REACTOME:R-BTA... | 240 | [
"1aam",
"1aat",
"1aaw",
"1ahe",
"1ahf",
"1ahg",
"1ahx",
"1ahy",
"1aia",
"1aib",
"1aic",
"1ajr",
"1ajs",
"1aka",
"1akb",
"1akc",
"1ama",
"1amq",
"1amr",
"1ams",
"1arg",
"1arh",
"1ari",
"1ars",
"1art",
"1asa",
"1asb",
"1asc",
"1asd",
"1ase",
"1asf",
"1asg"... | 1,791 | [
"PUB00006322",
"PUB00014087",
"PUB00035504",
"PUB00035505",
"PUB00035506",
"PUB00035507",
"PUB00035508",
"PUB00035511",
"PUB00035512",
"PUB00035513",
"PUB00035514",
"PUB00035515",
"PUB00153780",
"PUB00153781"
] | [
"7748903",
"10666573",
"15581583",
"8690703",
"15189147",
"17109392",
"16763894",
"17300176",
"16790938",
"15690345",
"17014820",
"15848278",
"20142041",
"36320885"
] | [
"Pyridoxal phosphate-dependent enzymes.",
"Three-dimensional structure of the Gly121Tyr dimeric form of ornithine decarboxylase from Lactobacillus 30a.",
"Reaction specificity in pyridoxal phosphate enzymes.",
"Pyridoxal enzymes: mechanistic diversity and uniformity.",
"Pyridoxal phosphate enzymes: mechanis... | [
1995,
1999,
2005,
1995,
2004,
2006,
2006,
2007,
2006,
2005,
2006,
2005,
2010,
2022
] | 14 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
20310,
907896,
272958,
295,
20702
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
412,
59,
130,
79,
41,
298,
164,
47,
329,
235,
34,
31,
753
] | 13 | true | Homologous_superfamily | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase | PyrdxlP-dep_Trfase | 1 |
IPR015425 | 15,425 | Formin, FH2 domain | FH2_Formin | Domain | 48,294 | false | false | Formin homology (FH) proteins play a crucial role in the reorganisation of the actin cytoskeleton, which mediates various functions of the cell cortex including motility, adhesion, and cytokinesis [ ]. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although s... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF02181",
"PS51444",
"SM00498"
] | [
"FH2",
"FH2",
"FH2"
] | [
46979,
47563,
43082
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-5663220",
"R-BTA-9013106",
"R-CEL-5663220",
"R-CEL-8980692",
"R-CEL-9013149",
"R-DME-5663220",
"R-DME-6785631",
"R-DME-6798695",
"R-DME-8980692",
"R-DME-9013026",
"R-DME-9013149",
"R-DME-9013404",
"R-DME-9013405",
"R-DME-9013406",
"R-DME-9013408",
"R-DME-9013423",
"R-DME-90350... | [
"REACTOME:R-BTA-5663220",
"REACTOME:R-BTA-9013106",
"REACTOME:R-CEL-5663220",
"REACTOME:R-CEL-8980692",
"REACTOME:R-CEL-9013149",
"REACTOME:R-DME-5663220",
"REACTOME:R-DME-6785631",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-8980692",
"REACTOME:R-DME-9013026",
"REACTOME:R-DME-9013149",
"REACTOM... | 60 | [
"1ux4",
"1ux5",
"1v9d",
"1y64",
"2j1d",
"2z6e",
"3o4x",
"3obv",
"4eah",
"8rtt",
"8rty",
"8ru2",
"8rv2",
"9az4",
"9azp",
"9azq",
"9b03",
"9b0k",
"9b27",
"9b3d"
] | 20 | [
"PUB00014909",
"PUB00014910",
"PUB00014911",
"PUB00014912",
"PUB00014913"
] | [
"10631086",
"12538772",
"14576350",
"14992721",
"15006353"
] | [
"Formin family proteins in cytoskeletal control.",
"ForC, a novel type of formin family protein lacking an FH1 domain, is involved in multicellular development in Dictyostelium discoideum.",
"Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic comp... | [
2000,
2003,
2003,
2004,
2004
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Heimdallarchaeum endolithica",
"Eukaryota",
"Viruses",
"bird metagenome"
] | [
27,
1,
48258,
6,
2
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
110,
19,
176,
39,
89,
53,
1,
44,
73,
2,
3,
143
] | 12 | true | Domain | Formin, FH2 domain | Formin, FH2 domain | FH2_Formin | 2 |
IPR015426 | 15,426 | Acetaldehyde dehydrogenase, C-terminal | Acetylaldehyde_DH_C | Domain | 5,993 | false | false | This C-terminal domain is found in prokaryotic acetaldehyde dehydrogenases, it adopts a structure consisting of an α-β-α-β(3) core, which mediates dimerisation of the protein [ ]. The acetaldehyde dehydrogenase family of bacterial enzymes catalyses the formation of acetyl-CoA from acetaldehyde in the 3-hydroxyphenylpro... | [
"GO:0008774",
"GO:0009056"
] | [
"acetaldehyde dehydrogenase (acetylating) activity",
"catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"CDD"
] | [
"PF09290",
"cd23933"
] | [
"AcetDehyd-dimer",
"ALDH_C"
] | [
5993,
5915
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.2.1.10",
"PWY-5162",
"PWY-5436",
"PWY-5480",
"PWY-6587",
"PWY-7085",
"PWY-7180",
"PWY-8060",
"PWY-8062"
] | [
"EC:1.2.1.10",
"METACYC:PWY-5162",
"METACYC:PWY-5436",
"METACYC:PWY-5480",
"METACYC:PWY-6587",
"METACYC:PWY-7085",
"METACYC:PWY-7180",
"METACYC:PWY-8060",
"METACYC:PWY-8062"
] | 9 | [
"1nvm",
"4jn6",
"4lrs",
"4lrt",
"7z3s",
"8ih7"
] | 6 | [
"PUB00016385",
"PUB00042979",
"PUB00067280",
"PUB00158508",
"PUB00158509"
] | [
"12764229",
"1732207",
"23614353",
"9169437",
"16788178"
] | [
"Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate.",
"Nucleotide sequence and functional analysis of the complete phenol/3,4-dimethylphenol catabolic pathway of Pseudomonas sp. strain CF600.",
"Characterization of an aldolase-dehydrogenase complex fro... | [
2003,
1992,
2013,
1997,
2006
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Bathycoccus sp. RCC716 virus 2",
"Eukaryota",
"Halobacteriales",
"Sym plasmid",
"unclassified sequences"
] | [
5926,
1,
8,
13,
1,
44
] | 6 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Acetaldehyde dehydrogenase, C-terminal | Acetaldehyde dehydrogenase, C-terminal | Acetylaldehyde_DH_C | 6 |
IPR015439 | 15,439 | Integrin beta-2 superfamily | Integrin_b-2_sf | Homologous_superfamily | 705 | false | false | Integrins are the major metazoan receptors for cell adhesion to extracellular matrix proteins and, in vertebrates, also play important roles in certain cell-cell adhesions, make transmembrane connections to the cytoskeleton, and activate many intracellular signalling pathways [ , ]. An integrin receptor is a heterodime... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:6.20.50.10"
] | [
""
] | [
705
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-166016",
"R-BTA-198933",
"R-BTA-202733",
"R-BTA-216083",
"R-BTA-6798695",
"R-HSA-166016",
"R-HSA-198933",
"R-HSA-202733",
"R-HSA-216083",
"R-HSA-6785807",
"R-HSA-6798695",
"R-MMU-166016",
"R-MMU-198933",
"R-MMU-202733",
"R-MMU-216083",
"R-MMU-6798695"
] | [
"REACTOME:R-BTA-166016",
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-202733",
"REACTOME:R-BTA-216083",
"REACTOME:R-BTA-6798695",
"REACTOME:R-HSA-166016",
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-... | 16 | [
"1yuk",
"2p26",
"2p28",
"3k6s",
"3k71",
"3k72",
"4neh",
"4nen",
"5e6r",
"5e6s",
"5e6u",
"5e6v",
"5e6w",
"5e6x",
"5es4",
"7p2d",
"7usl",
"7usm"
] | 18 | [
"PUB00009789",
"PUB00015915",
"PUB00015985",
"PUB00035000",
"PUB00035002",
"PUB00035005",
"PUB00035006",
"PUB00035007"
] | [
"12297042",
"14689578",
"2467745",
"12361595",
"12234368",
"10766246",
"11812992",
"12130787"
] | [
"Integrins: bidirectional, allosteric signaling machines.",
"Integrin clipping: a novel adhesion switch?",
"A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells.",
"Integrins in development: moving on, responding to, and sticking to the extr... | [
2002,
2004,
1989,
2002,
2002,
2000,
2002,
2002
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
705
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
7,
5
] | 3 | true | Homologous_superfamily | Integrin beta-2 superfamily | Integrin beta-2 superfamily | Integrin_b-2_sf | 9 |
IPR015445 | 15,445 | TATA-Box binding protein-like 1 | TBP-like | Family | 1,417 | false | false | This entry refers to TATA box-binding protein-like 1 proteins also known as TBP-like 1. TATA-Box binding protein (TBP) is a general factor that plays a central role in the activation of eukaryotic genes transcribed by RNA polymerase II [ , ]. TBP binds specifically to the TATA-box promoter element, which lies close to ... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd04517"
] | [
"TLF"
] | [
1417
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00004068",
"PUB00004069",
"PUB00017041",
"PUB00044510",
"PUB00080143",
"PUB00080157",
"PUB00080158",
"PUB00080159"
] | [
"2374612",
"2197561",
"12878007",
"16858867",
"14685269",
"11051541",
"10470030",
"15767669"
] | [
"Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID).",
"Arabidopsis thaliana contains two genes for TFIID.",
"The genetics of TBP and TBP-related factors.",
"The general transcription machinery and general cofactors.",
"The multicoloured worl... | [
1990,
1990,
2003,
2006,
2004,
2000,
1999,
2005
] | 8 | [
"IPR000814"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1417
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
5,
2,
2,
5
] | 6 | true | Family | TATA-Box binding protein-like 1 | TATA-Box binding protein-like 1 | TBP-like | 9 |
IPR015446 | 15,446 | Bone morphogenetic protein 1/tolloid-like protein | BMP_1/tolloid-like | Family | 4,731 | false | false | This entry includes metalloproteases that serve as activators of a broader subset of the TGFbeta superfamily of proteins and are involved in the morphogenetic processes [ ]. Members of this family are bone morphogenetic protein 1 (BMP1), tolloid-like protein1/2 from mammals, dorsal-ventral patterning protein tolloid fr... | [
"GO:0004222"
] | [
"metalloendopeptidase activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF"
] | [
"PIRSF001199"
] | [
"BMP_1/tolloid-like"
] | [
4731
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.24.-",
"PWY-8119",
"R-CEL-1474228",
"R-CEL-1650814",
"R-CEL-2214320",
"R-DME-1474228",
"R-DME-1650814",
"R-DME-2243919",
"R-DRE-1650814",
"R-DRE-2243919",
"R-HSA-1474228",
"R-HSA-1650814",
"R-HSA-2214320",
"R-HSA-2243919",
"R-HSA-8963896",
"R-MMU-1650814",
"R-MMU-2214320",
"R-... | [
"EC:3.4.24.-",
"METACYC:PWY-8119",
"REACTOME:R-CEL-1474228",
"REACTOME:R-CEL-1650814",
"REACTOME:R-CEL-2214320",
"REACTOME:R-DME-1474228",
"REACTOME:R-DME-1650814",
"REACTOME:R-DME-2243919",
"REACTOME:R-DRE-1650814",
"REACTOME:R-DRE-2243919",
"REACTOME:R-HSA-1474228",
"REACTOME:R-HSA-1650814",... | 19 | [] | 0 | [
"PUB00072406"
] | [
"17560775"
] | [
"The bone morphogenetic protein 1/Tolloid-like metalloproteinases."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
4731
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
10,
7,
8,
9
] | 6 | true | Family | Bone morphogenetic protein 1/tolloid-like protein | Bone morphogenetic protein 1/tolloid-like protein | BMP_1/tolloid-like | 4 |
IPR015449 | 15,449 | Potassium channel, calcium-activated, SK | K_chnl_Ca-activ_SK | Family | 8,618 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0016286",
"GO:0006813",
"GO:0016020"
] | [
"small conductance calcium-activated potassium channel activity",
"potassium ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF03530",
"PR01451",
"PTHR10153"
] | [
"SK_channel",
"SKCHANNEL",
""
] | [
6271,
3424,
8553
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-1296052",
"R-DME-1296052",
"R-HSA-1296052",
"R-HSA-9667769",
"R-MMU-1296052",
"R-RNO-1296052",
"R-SSC-1296052"
] | [
"REACTOME:R-CEL-1296052",
"REACTOME:R-DME-1296052",
"REACTOME:R-HSA-1296052",
"REACTOME:R-HSA-9667769",
"REACTOME:R-MMU-1296052",
"REACTOME:R-RNO-1296052",
"REACTOME:R-SSC-1296052"
] | 7 | [
"1g4y",
"1kkd",
"1qx7",
"3sjq",
"4g27",
"4g28",
"4j9y",
"4j9z",
"4qnh",
"5v02",
"5v03",
"5wbx",
"5wc5",
"6ale",
"6cnm",
"6cnn",
"6cno",
"6czq",
"8v2g",
"8v2h",
"8v3g",
"9ed1",
"9eio",
"9o48",
"9o51",
"9o52",
"9o53",
"9o5o",
"9o7s",
"9o85",
"9o93",
"9oa8"... | 34 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00008285",
"PUB00009378",
"PUB00035208",
"PUB00035209",
"PUB00035210",
"PUB00035211",
"PUB00035212",
"PUB00035213",
"PUB00036011"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"9687354",
"11178249",
"2432249",
"7993625",
"6099412",
"2430185",
"9280156",
"10390643",
"8781233"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
1998,
2000,
1986,
1994,
1984,
1986,
1997,
1999,
1996
] | 15 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
85,
8533
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
27,
10,
28,
18,
36
] | 6 | true | Family | Potassium channel, calcium-activated, SK | Potassium channel, calcium-activated, SK | K_chnl_Ca-activ_SK | 5 |
IPR015458 | 15,458 | MDM4 | MDM4 | Family | 872 | false | false | MDM4, also known as MDMX, is a MDM2-related protein that has been shown to inhibit p53, although not as well as MDM2 [ , ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF500699"
] | [
"MDM4"
] | [
872
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DRE-2559580",
"R-DRE-2559585",
"R-DRE-6804757",
"R-DRE-69541",
"R-HSA-2559580",
"R-HSA-2559585",
"R-HSA-5689880",
"R-HSA-6804756",
"R-HSA-6804757",
"R-HSA-6804760",
"R-HSA-69541",
"R-MMU-2559580",
"R-MMU-2559585",
"R-MMU-5689880",
"R-MMU-6804756",
"R-MMU-6804757",
"R-MMU-6804760",... | [
"REACTOME:R-DRE-2559580",
"REACTOME:R-DRE-2559585",
"REACTOME:R-DRE-6804757",
"REACTOME:R-DRE-69541",
"REACTOME:R-HSA-2559580",
"REACTOME:R-HSA-2559585",
"REACTOME:R-HSA-5689880",
"REACTOME:R-HSA-6804756",
"REACTOME:R-HSA-6804757",
"REACTOME:R-HSA-6804760",
"REACTOME:R-HSA-69541",
"REACTOME:R-... | 25 | [] | 0 | [
"PUB00059214",
"PUB00059215"
] | [
"6163388",
"16511572"
] | [
"Serum immunoreactive trypsin and trypsin inhibitors during acute pancreatitis.",
"14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation."
] | [
1980,
2006
] | 2 | [
"IPR016495"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
872
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
4,
6
] | 4 | true | Family | MDM4 | MDM4 | MDM4 | 8 |
IPR015468 | 15,468 | CD8 alpha subunit | CD8_asu | Family | 1,222 | false | false | The CD8 alpha subunit is a component of the CD8 α-β heterodimer and is additionally found as a homodimeric complex [ ]. Both of these species assist in the recognition of MHC class I-peptide complexes by the α-β T cell receptor (TCR). CD8 binds to constant regions of the peptide-MHC complex and augments antigen-specifi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10441"
] | [
""
] | [
1222
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-198933",
"R-HSA-198933",
"R-MMU-198933",
"R-RNO-198933"
] | [
"REACTOME:R-CFA-198933",
"REACTOME:R-HSA-198933",
"REACTOME:R-MMU-198933",
"REACTOME:R-RNO-198933"
] | 4 | [
"1akj",
"1bqh",
"1cd8",
"1nez",
"2arj",
"2atp",
"2hp4",
"2q3a",
"3b9k",
"3dmm",
"3qzw",
"5eb9",
"5ebg",
"5edx",
"5z11",
"6lhf",
"6lhg",
"7umg",
"7uvf",
"8ew6",
"8hxs",
"9jl0"
] | 22 | [
"PUB00034830",
"PUB00034831",
"PUB00034832"
] | [
"10493174",
"12133804",
"2107025"
] | [
"Molecular analysis of protein interactions mediating the function of the cell surface protein CD8.",
"Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands.",
"Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytop... | [
1999,
2002,
1990
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1222
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
9,
3
] | 4 | true | Family | CD8 alpha subunit | CD8 alpha subunit | CD8_asu | 6 |
IPR015476 | 15,476 | Calcitonin gene-related peptide | Calcitonin_gene-rel_peptide | Family | 816 | false | false | The calcitonin (CT) gene is alternatively expressed in a tissue-specific manner, producing either the calcium regulatory hormone CT in the thyroid, or the neuropeptide calcitonin gene related peptide (CGRP) in the brain [ ]. In medullary carcinoma of the thyroid, both peptides are produced [ ]. The calcitonin regulator... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR00817"
] | [
"CALCITONINB"
] | [
816
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-419812",
"R-HSA-418555",
"R-HSA-419812",
"R-MMU-418555",
"R-MMU-419812",
"R-RNO-419812",
"R-SSC-418555",
"R-SSC-419812"
] | [
"REACTOME:R-CFA-419812",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-419812",
"REACTOME:R-MMU-418555",
"REACTOME:R-MMU-419812",
"REACTOME:R-RNO-419812",
"REACTOME:R-SSC-418555",
"REACTOME:R-SSC-419812"
] | 8 | [
"6e3y",
"7knu",
"9auc"
] | 3 | [
"PUB00000335",
"PUB00000353",
"PUB00000472",
"PUB00001543"
] | [
"1931969",
"1988044",
"3060108",
"2985435"
] | [
"Solution conformation of salmon calcitonin in sodium dodecyl sulfate micelles as determined by two-dimensional NMR and distance geometry calculations.",
"Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.",
"Peptides from the calciton... | [
1991,
1991,
1988,
1985
] | 4 | [
"IPR021117"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
816
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
4,
7
] | 4 | true | Family | Calcitonin gene-related peptide | Calcitonin gene-related peptide | Calcitonin_gene-rel_peptide | 2 |
IPR015482 | 15,482 | Syntrophin | Syntrophin | Family | 6,800 | false | false | The syntrophin family are intracellular membrane-associated proteins that interact with both ion channels and signalling proteins. As such, syntrophins appear to be important for linking ion channels to intracellular signalling pathways. Syntrophins are concentrated at postsynaptic sites at the neuromuscular junction a... | [
"GO:0005198"
] | [
"structural molecule activity"
] | [
"molecular_function"
] | 1 | [
"PANTHER"
] | [
"PTHR10554"
] | [
""
] | [
6800
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9913351",
"R-CEL-9913351",
"R-HSA-9913351",
"R-MMU-9913351"
] | [
"REACTOME:R-BTA-9913351",
"REACTOME:R-CEL-9913351",
"REACTOME:R-HSA-9913351",
"REACTOME:R-MMU-9913351"
] | 4 | [
"1qav",
"1z86",
"1z87",
"2adz",
"2pdz",
"2vrf",
"4hop"
] | 7 | [
"PUB00034889",
"PUB00034890"
] | [
"7691103",
"9210230"
] | [
"Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution.",
"Syntrophins: modular adapter proteins at the neuromuscular junction and the sarcolemma."
] | [
1993,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6800
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
16,
11,
33,
16,
18
] | 6 | true | Family | Syntrophin | Syntrophin | Syntrophin | 4 |
IPR015484 | 15,484 | CD3 protein, epsilon/gamma/delta subunit | CD3_esu/gsu/dsu | Family | 2,245 | false | false | The closely related CD3 epsilon, gamma and delta subunits constitute part of the invariant portion of the T cell receptor (TCR) complex. Both are transmembrane proteins with immunoglobulin-like domains in their extracellular regions. Each protein contains a single immunoreceptor tyrosine-based activation motif (ITAM) i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10570"
] | [
""
] | [
2245
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-198933",
"R-BTA-202424",
"R-BTA-202427",
"R-BTA-202430",
"R-BTA-202433",
"R-BTA-389948",
"R-BTA-8856825",
"R-BTA-8856828",
"R-CFA-198933",
"R-CFA-202424",
"R-CFA-202427",
"R-CFA-202430",
"R-CFA-202433",
"R-CFA-389948",
"R-HSA-198933",
"R-HSA-202424",
"R-HSA-202427",
"R-HSA-2... | [
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-202427",
"REACTOME:R-BTA-202430",
"REACTOME:R-BTA-202433",
"REACTOME:R-BTA-389948",
"REACTOME:R-BTA-8856825",
"REACTOME:R-BTA-8856828",
"REACTOME:R-CFA-198933",
"REACTOME:R-CFA-202424",
"REACTOME:R-CFA-202427",
"REACTOME:R-CFA-2... | 60 | [
"1jbj",
"1sy6",
"1xiw",
"1xmw",
"2mim",
"3r08",
"6jxr",
"7fjd",
"7fje",
"7fjf",
"7phr",
"8es7",
"8es8",
"8es9",
"8jc0",
"8jcb",
"8tw4",
"8tw6",
"8wxe",
"8wy0",
"8wyi",
"8yc0",
"8za6",
"9bbc",
"9c3e",
"9ci8",
"9cia",
"9cq4",
"9ip8",
"9ip9",
"9ipa",
"9ipc"... | 37 | [
"PUB00016636"
] | [
"14552840"
] | [
"T-cell receptor signal transmission: who gives an ITAM?"
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
2245
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
13,
14,
14
] | 4 | true | Family | CD3 protein, epsilon/gamma/delta subunit | CD3 protein, epsilon/gamma/delta subunit | CD3_esu/gsu/dsu | 9 |
IPR015495 | 15,495 | Myb transcription factor, plants | Myb_TF_plants | Family | 34,902 | false | false | This entry represents a group of Myb transcription factors from plants which are involved in a variety of plant developmental processes and stress responses [ ]. Members of the family play crucial roles in anther development, microsporogenesis, and tapetal function, which are essential for pollen development. They are ... | [] | [] | [] | 0 | [
"PANTHER",
"PANTHER",
"PANTHER",
"PANTHER"
] | [
"PTHR10641",
"PTHR47994",
"PTHR47998",
"PTHR47999"
] | [
"",
"",
"",
""
] | [
10597,
11460,
3554,
9291
] | 4 | [] | [] | [] | 0 | [
"6kks",
"7fdl",
"7fdo"
] | 3 | [
"PUB00001152",
"PUB00004032",
"PUB00005459",
"PUB00098010",
"PUB00107896",
"PUB00150143",
"PUB00153079",
"PUB00155084"
] | [
"2824190",
"3185713",
"8882580",
"23943862",
"15361138",
"15728674",
"26184177",
"22814374"
] | [
"The highly conserved amino-terminal region of the protein encoded by the v-myb oncogene functions as a DNA-binding domain.",
"Viral myb oncogene encodes a sequence-specific DNA-binding activity.",
"The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor... | [
1987,
1988,
1996,
2013,
2004,
2005,
2015,
2012
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
34902
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
325,
144,
276
] | 3 | true | Family | Myb transcription factor, plants | Myb transcription factor, plants | Myb_TF_plants | 1 |
IPR015496 | 15,496 | Ubiquilin | Ubiquilin | Family | 11,619 | false | false | Ubiquitin [ ] is a protein of seventy six amino acid residues, found in all eukaryotic cells and whose sequence is extremely well conserved from protozoan to vertebrates. It is widely known as a post-translational tag used to signal a protein's hydrolytic destruction. Other functions for ubiquitin, depend on its differ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10677"
] | [
""
] | [
11619
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1169408",
"R-BTA-5656169",
"R-BTA-936440",
"R-BTA-9833482",
"R-BTA-9909505",
"R-CEL-8856825",
"R-DDI-8856825",
"R-HSA-1169408",
"R-HSA-168276",
"R-HSA-168928",
"R-HSA-5205685",
"R-HSA-5656169",
"R-HSA-5675482",
"R-HSA-5689877",
"R-HSA-8856825",
"R-HSA-909733",
"R-HSA-936440",
... | [
"REACTOME:R-BTA-1169408",
"REACTOME:R-BTA-5656169",
"REACTOME:R-BTA-936440",
"REACTOME:R-BTA-9833482",
"REACTOME:R-BTA-9909505",
"REACTOME:R-CEL-8856825",
"REACTOME:R-DDI-8856825",
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-168276",
"REACTOME:R-HSA-168928",
"REACTOME:R-HSA-5205685",
"REACTOME:R... | 42 | [
"1iyf",
"1j8c",
"1mg8",
"1vej",
"1wx7",
"1wx8",
"1x1m",
"1yqb",
"1z2m",
"2bwe",
"2bwf",
"2dah",
"2jy5",
"2jy6",
"2klc",
"2knb",
"2knz",
"2mlb",
"2mqj",
"2nbv",
"2zeq",
"3b1l",
"3m63",
"3pse",
"3r66",
"3rt3",
"3sdl",
"4k95",
"4zyn",
"5c1z",
"5c23",
"5chf"... | 64 | [
"PUB00000623",
"PUB00034999"
] | [
"1647207",
"12645912"
] | [
"Genetic analysis of the ubiquitin system.",
"The ubiquitin superfamily: members, features, and phylogenies."
] | [
1991,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Caldiarchaeum subterraneum",
"Eukaryota",
"metagenomes",
"unclassified Klosneuvirinae"
] | [
4,
11610,
3,
2
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
2,
9,
4,
37,
29,
1,
11,
39,
1,
1,
37
] | 12 | true | Family | Ubiquilin | Ubiquilin | Ubiquilin | 9 |
IPR015499 | 15,499 | Cholecystokinin-like | CCK-like | Family | 1,229 | false | false | Gastrin and cholecystokinin (CCK) are structurally and functionally related peptide hormones that function as hormonal regulators of various digestive processes and feeding behaviours. They are known to induce gastric secretion, stimulate pancreatic secretion, increase blood circulation and water secretion in the stoma... | [
"GO:0005184",
"GO:0007586"
] | [
"neuropeptide hormone activity",
"digestion"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR10786"
] | [
""
] | [
1229
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-375276",
"R-BTA-416476",
"R-HSA-375276",
"R-HSA-416476",
"R-MMU-375276",
"R-MMU-416476",
"R-RNO-375276",
"R-RNO-416476",
"R-SSC-375276",
"R-SSC-416476"
] | [
"REACTOME:R-BTA-375276",
"REACTOME:R-BTA-416476",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-416476",
"REACTOME:R-SSC-375276",
"REACTOME:R-SSC-416476"
] | 10 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1229
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
3,
6
] | 4 | true | Family | Cholecystokinin-like | Cholecystokinin-like | CCK-like | 4 |
IPR015505 | 15,505 | Coronin | Coronin | Family | 15,037 | false | false | Coronins are evoluntionarily conserved WD-repeat-containing proteins mostly involved in actin cytoskeleton organisation. The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes [ ]. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins contain... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10856"
] | [
""
] | [
15037
] | 1 | [
"REACTOME"
] | [
"R-HSA-9636383"
] | [
"REACTOME:R-HSA-9636383"
] | 1 | [
"2aq5",
"2b4e",
"4ozu",
"7kyx",
"7sty",
"9qey",
"9qf2",
"9qfb",
"9qfe",
"9qfg",
"9qfk"
] | 11 | [
"PUB00014164",
"PUB00035080",
"PUB00035082",
"PUB00039364",
"PUB00063875",
"PUB00063876",
"PUB00063877",
"PUB00063878",
"PUB00063888",
"PUB00063890",
"PUB00063893"
] | [
"11761326",
"10461187",
"12499356",
"16407068",
"18925375",
"15892111",
"18925371",
"18925376",
"18775315",
"17350576",
"1661669"
] | [
"Pyrroloquinoline quinone (PQQ) and quinoprotein enzymes.",
"The coronin family of actin-associated proteins.",
"Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin.",
"The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocyt... | [
2001,
1999,
2002,
2006,
2008,
2005,
2008,
2008,
2008,
2007,
1991
] | 11 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
15037
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
5,
41,
7,
65,
45,
1,
36,
1,
1
] | 9 | true | Family | Coronin | Coronin | Coronin | 7 |
IPR015507 | 15,507 | Ribosomal RNA large subunit methyltransferase E | rRNA-MeTfrase_E | Family | 22,125 | false | false | The ribosomal RNA large subunit methyltransferase E ( ) methylates the 23S rRNA. It specifically methylates the uridine in position 2552 of 23s rRNA in the 50S particle using S-adenosyl-L-methionine as a substrate [ ]. It was previously known as cell division protein FtsJ. This entry represents the ribosomal RNA large ... | [
"GO:0008168",
"GO:0001510"
] | [
"methyltransferase activity",
"RNA methylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PIRSF"
] | [
"MF_01547",
"PIRSF005461"
] | [
"RNA_methyltr_E",
"23S_rRNA_mtase"
] | [
21824,
12711
] | 2 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.1",
"2.1.1.166",
"R-HSA-6782315",
"R-HSA-6791226",
"R-HSA-6793080",
"R-MMU-6791226",
"R-RNO-6791226"
] | [
"EC:2.1.1",
"EC:2.1.1.166",
"REACTOME:R-HSA-6782315",
"REACTOME:R-HSA-6791226",
"REACTOME:R-HSA-6793080",
"REACTOME:R-MMU-6791226",
"REACTOME:R-RNO-6791226"
] | 7 | [
"1eiz",
"1ej0",
"2nyu",
"2plw",
"3dou",
"6elz",
"6em5",
"6jp6",
"6jpl",
"6ylx",
"7nac",
"7nad",
"7naf",
"7o9k",
"7o9m",
"7ods",
"7ohr",
"7ohv",
"7r6k",
"7r72",
"7r7a",
"7r7o",
"7u0h",
"8esq",
"8esr",
"8etc",
"8etj",
"8fkp",
"8fkq",
"8fkr",
"8fks",
"8fkt"... | 48 | [
"PUB00016804",
"PUB00054996"
] | [
"10748051",
"11927565"
] | [
"The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase.",
"Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop."
] | [
2000,
2002
] | 2 | [] | [
"IPR004512",
"IPR028589",
"IPR028590"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
703,
9534,
11735,
153
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
17,
5,
7,
5,
1,
9,
3,
4,
8,
6,
3,
3,
21
] | 13 | true | Family | Ribosomal RNA large subunit methyltransferase E | Ribosomal RNA large subunit methyltransferase E | rRNA-MeTfrase_E | 4 |
IPR015510 | 15,510 | Peptidoglycan recognition protein | PGRP | Family | 16,913 | false | false | This is a group of animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme [ ]. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member, Tag7, is a cytokine [ ]. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR11022"
] | [
""
] | [
16913
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6798695",
"R-BTA-6803157",
"R-DME-209171",
"R-DME-209266",
"R-DME-214397",
"R-DME-214399",
"R-DME-214411",
"R-DME-214416",
"R-DME-6798695",
"R-DME-6803157",
"R-HSA-6798695",
"R-HSA-6803157",
"R-MMU-6798695",
"R-MMU-6803157",
"R-RNO-6798695",
"R-RNO-6803157"
] | [
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-6803157",
"REACTOME:R-DME-209171",
"REACTOME:R-DME-209266",
"REACTOME:R-DME-214397",
"REACTOME:R-DME-214399",
"REACTOME:R-DME-214411",
"REACTOME:R-DME-214416",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-6803157",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HS... | 16 | [
"1aro",
"1lba",
"1oht",
"1s2j",
"1sk3",
"1sk4",
"1sxr",
"1twq",
"1yck",
"1z6i",
"2aph",
"2cb3",
"2eav",
"2eax",
"2f2l",
"2r2k",
"2r90",
"2rkq",
"2xz4",
"2xz8",
"2z9n",
"3c2x",
"3cg9",
"3cor",
"3cxa",
"3ep1",
"3ng4",
"3nno",
"3nw3",
"3o4k",
"3ogx",
"3qj1"... | 73 | [
"PUB00009690",
"PUB00009691"
] | [
"9707603",
"9660837"
] | [
"A peptidoglycan recognition protein in innate immunity conserved from insects to humans.",
"Molecular cloning and characterization of the mouse tag7 gene encoding a novel cytokine."
] | [
1998,
1998
] | 2 | [] | [
"IPR017331",
"IPR034689"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Methanosarcina mazei",
"Viruses",
"metagenomes"
] | [
9452,
6734,
2,
613,
112
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
36,
4,
12,
15
] | 5 | true | Family | Peptidoglycan recognition protein | Peptidoglycan recognition protein | PGRP | 1 |
IPR015513 | 15,513 | Semaphorin 3E, Sema domain | Semaphorin_3E_Sema | Domain | 555 | false | false | This entry represents the Sema domain of Semaphorin 3E, a protein interacting module located at the N-terminal end that contain four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module [ ]. Semaphorins were first cloned as recognised mediators of cellular... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd11253"
] | [
"Sema_3E"
] | [
555
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-416700",
"R-MMU-416700"
] | [
"REACTOME:R-HSA-416700",
"REACTOME:R-MMU-416700"
] | 2 | [] | 0 | [
"PUB00015414",
"PUB00034855",
"PUB00034856",
"PUB00034857",
"PUB00034858",
"PUB00034879"
] | [
"12925274",
"11956234",
"10520995",
"10520994",
"10934324",
"12213213"
] | [
"Structure of the semaphorin-3A receptor binding module.",
"Semaphorins as signals for cell repulsion and invasion.",
"Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.",
"Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.",
... | [
2003,
2002,
1999,
1999,
2000,
2002
] | 6 | [
"IPR001627"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
555
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
1,
5
] | 4 | true | Domain | Semaphorin 3E, Sema domain | Semaphorin 3E, Sema domain | Semaphorin_3E_Sema | 9 |
IPR015517 | 15,517 | Deoxycytidylate deaminase-related | dCMP_deaminase-rel | Family | 17,605 | false | false | Deoxycytidylate deaminase ( ) (dCMP deaminase) hydrolyzes deoxycytidylate mono phosphate (dCMP) into deoxyuridine mono phosphate (dUMP), thus providing the nucleotide substrate for thymidylate synthase. The enzyme requires zinc for catalytic activity which is regulated by the ratio of dCTP to dTTP, both the end product... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR11086"
] | [
""
] | [
17605
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.4.12",
"PWY-7210",
"R-HSA-499943",
"R-MMU-499943",
"R-RNO-499943"
] | [
"EC:3.5.4.12",
"METACYC:PWY-7210",
"REACTOME:R-HSA-499943",
"REACTOME:R-MMU-499943",
"REACTOME:R-RNO-499943"
] | 5 | [
"1vq2",
"2hvv",
"2hvw",
"2w4l",
"4p9c",
"4p9d",
"4p9e",
"5c2o",
"7fh4",
"7fh9",
"9hfq",
"9hfr",
"9hfs",
"9hft"
] | 14 | [
"PUB00002807",
"PUB00047647",
"PUB00070796",
"PUB00070799"
] | [
"8428902",
"18255096",
"7685356",
"16955368"
] | [
"T4-phage deoxycytidylate deaminase is a metalloprotein containing two zinc atoms per subunit.",
"Crystal structures of Streptococcus mutans 2'-deoxycytidylate deaminase and its complex with substrate analog and allosteric regulator dCTP x Mg2+.",
"Primary structure of human deoxycytidylate deaminase and overex... | [
1993,
2008,
1993,
2006
] | 4 | [] | [
"IPR013404",
"IPR016473"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
307,
9875,
5871,
1150,
402
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
4,
2,
15,
7,
1,
5,
21,
1,
1,
9
] | 12 | true | Family | Deoxycytidylate deaminase-related | Deoxycytidylate deaminase-related | dCMP_deaminase-rel | 7 |
IPR015520 | 15,520 | Imaginal disc growth factor | IDGF | Family | 484 | false | false | Imaginal disc growth factors (IDGFs), also known as chitinase-like proteins, are soluble factors involved in the regulation of proliferation in imaginal discs [ ]. They are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster [ ]. The... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd02873"
] | [
"GH18_IDGF"
] | [
484
] | 1 | [
"REACTOME"
] | [
"R-DME-6798695"
] | [
"REACTOME:R-DME-6798695"
] | 1 | [
"1jnd",
"1jne",
"9g3q"
] | 3 | [
"PUB00026449",
"PUB00034892",
"PUB00085931",
"PUB00085932"
] | [
"11821393",
"11444043",
"17594485",
"12242232"
] | [
"Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster.",
"Growth factors controlling imaginal disc growth in Drosophila.",
"Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family.",
... | [
2002,
2001,
2007,
2002
] | 4 | [
"IPR050314"
] | [] | 1 | 0 | 1 | [
"Neoptera"
] | [
484
] | 1 | [
"Drosophila melanogaster"
] | [
20
] | 1 | true | Family | Imaginal disc growth factor | Imaginal disc growth factor | IDGF | 1 |
IPR015525 | 15,525 | Breast cancer type 2 susceptibility protein | BRCA2 | Family | 4,600 | false | false | The breast cancer type 2 susceptibility protein (BRCA2) is a breast tumour suppressor involved in double-strand break repair and/or homologous recombination [ ]. BRCA2 gene expression is regulated in a cell-cycle dependent manner and peak expression of BRCA2 mRNA occurring in S phase, suggesting BRCA2 may participate i... | [
"GO:0000724",
"GO:0006281"
] | [
"double-strand break repair via homologous recombination",
"DNA repair"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF002397",
"PTHR11289"
] | [
"BRCA2",
""
] | [
1251,
4600
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-5685939",
"R-HSA-5685942",
"R-HSA-5693554",
"R-HSA-5693568",
"R-HSA-5693579",
"R-HSA-5693616",
"R-HSA-912446",
"R-HSA-9701192",
"R-HSA-9704331",
"R-HSA-9704646",
"R-HSA-9709275",
"R-HSA-9709570",
"R-HSA-9709603",
"R-HSA-9763198",
"R-MMU-5685939",
"R-MMU-5685942",
"R-MMU-569356... | [
"REACTOME:R-HSA-5685939",
"REACTOME:R-HSA-5685942",
"REACTOME:R-HSA-5693554",
"REACTOME:R-HSA-5693568",
"REACTOME:R-HSA-5693579",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-912446",
"REACTOME:R-HSA-9701192",
"REACTOME:R-HSA-9704331",
"REACTOME:R-HSA-9704646",
"REACTOME:R-HSA-9709275",
"REACTOME... | 24 | [
"1iyj",
"1miu",
"1mje"
] | 3 | [
"PUB00003901",
"PUB00005803",
"PUB00005815",
"PUB00005834",
"PUB00007172",
"PUB00027524",
"PUB00066909",
"PUB00085103"
] | [
"8673099",
"9405383",
"9560268",
"9811893",
"10551859",
"12442171",
"20513136",
"22077663"
] | [
"Internal repeats in the BRCA2 protein sequence.",
"RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2.",
"The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.",
"The BRCA2 gene product funct... | [
1996,
1997,
1998,
1998,
1999,
2002,
2010,
2012
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4600
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
18,
3,
1,
92,
5,
7,
7,
34
] | 8 | true | Family | Breast cancer type 2 susceptibility protein | Breast cancer type 2 susceptibility protein | BRCA2 | 8 |
IPR015526 | 15,526 | Frizzled/secreted frizzled-related protein | Frizzled/SFRP | Family | 21,842 | false | false | This entry includes both frizzled proteins and secreted frizzled-related proteins (SFRP). Frizzleds are seven transmembrane-spanning proteins that constitute an unconventional class of G protein-coupled receptors [ ]. They have important regulatory roles during embryonic development [ , ]. Frizzleds expose their large ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR11309"
] | [
""
] | [
21842
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-4086398",
"R-CEL-4086400",
"R-CEL-4608870",
"R-CEL-4641262",
"R-CEL-4641263",
"R-CEL-5140745",
"R-DME-209214",
"R-DME-209338",
"R-DME-209387",
"R-DME-209440",
"R-DME-209472",
"R-DME-216119",
"R-DME-216217",
"R-DME-350368",
"R-DME-350376",
"R-DME-350379",
"R-DME-350411",
"R-D... | [
"REACTOME:R-CEL-4086398",
"REACTOME:R-CEL-4086400",
"REACTOME:R-CEL-4608870",
"REACTOME:R-CEL-4641262",
"REACTOME:R-CEL-4641263",
"REACTOME:R-CEL-5140745",
"REACTOME:R-DME-209214",
"REACTOME:R-DME-209338",
"REACTOME:R-DME-209387",
"REACTOME:R-DME-209440",
"REACTOME:R-DME-209472",
"REACTOME:R-D... | 79 | [
"1ijx",
"1ijy",
"2mah",
"4c79",
"4c7a",
"4f0a",
"4jkv",
"4n4w",
"4o9r",
"4qim",
"4qin",
"5bpb",
"5bpq",
"5bqc",
"5bqe",
"5cl1",
"5cm4",
"5kzv",
"5kzy",
"5kzz",
"5l7d",
"5l7i",
"5t44",
"5un5",
"5un6",
"5urv",
"5ury",
"5urz",
"5uwg",
"5v56",
"5v57",
"5wbs"... | 81 | [
"PUB00001934",
"PUB00004042",
"PUB00033723",
"PUB00060605",
"PUB00060609",
"PUB00060610",
"PUB00061907"
] | [
"2174014",
"2493583",
"11452312",
"10347172",
"17884187",
"21314612",
"9288750"
] | [
"Molecular structure of frizzled, a Drosophila tissue polarity gene.",
"A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains.",
"Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.",
"Interaction of frizzled relat... | [
1990,
1989,
2001,
1999,
2007,
2010,
1997
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Kangiella spongicola"
] | [
21841,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
39,
22,
44,
40,
45
] | 6 | true | Family | Frizzled/secreted frizzled-related protein | Frizzled/secreted frizzled-related protein | Frizzled/SFRP | 3 |
IPR015527 | 15,527 | Peptidase C26, gamma-glutamyl hydrolase | Pept_C26_g-glut_hydrolase | Family | 4,228 | false | false | Gamma-glutamyl hydrolase (GH) is a lysosomal and secreted glycoprotein that hydrolyses the gamma-glutamyl tail of antifolate and folate polyglutamates. Tumour cells that have high levels of GH are inherently resistant to classical antifolates, and further resistance can be acquired by elevations in GH following exposur... | [
"GO:0008242"
] | [
"omega peptidase activity"
] | [
"molecular_function"
] | 1 | [
"PROFILE",
"PANTHER"
] | [
"PS51275",
"PTHR11315"
] | [
"PEPTIDASE_C26_GGH",
""
] | [
4084,
4179
] | 2 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.19.9",
"PWY-2161",
"R-BTA-6798695",
"R-DDI-6798695",
"R-HSA-6798695",
"R-MMU-6798695",
"R-RNO-6798695"
] | [
"EC:3.4.19.9",
"METACYC:PWY-2161",
"REACTOME:R-BTA-6798695",
"REACTOME:R-DDI-6798695",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-6798695"
] | 7 | [
"1l9x",
"4l7q",
"4l8f",
"4l8w",
"4l8y",
"4l95"
] | 6 | [
"PUB00015219",
"PUB00034829"
] | [
"11953431",
"10739875"
] | [
"Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate.",
"Glutamyl hydrolase. pharmacological role and enzymatic characterization."
] | [
2002,
2000
] | 2 | [
"IPR011697"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Megaviricetes",
"metagenomes"
] | [
4196,
6,
26
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
17,
5,
3,
7,
3,
3,
2,
16
] | 8 | true | Family | Peptidase C26, gamma-glutamyl hydrolase | Peptidase C26, gamma-glutamyl hydrolase | Pept_C26_g-glut_hydrolase | 3 |
IPR015528 | 15,528 | Interleukin-12 beta | IL-12_beta | Family | 1,304 | false | false | This entry represents Interleukin-12 beta. Interleukins are a group of cytokines that have important roles in cell growth, differentiation, and motility, and in the functioning of the immune system. Interleukin-12 (also known as natural killer cell stimulatory factor, and cytotoxic lymphocyte maturation factor) is a 75... | [] | [] | [] | 0 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF038007",
"PR01928"
] | [
"IL_12_beta",
"INTRLEUKN12B"
] | [
943,
1277
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6783783",
"R-HSA-6785807",
"R-HSA-9020591",
"R-HSA-9020933",
"R-MMU-9020591",
"R-MMU-9020933",
"R-SSC-9020591",
"R-SSC-9020933"
] | [
"REACTOME:R-HSA-6783783",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-9020591",
"REACTOME:R-HSA-9020933",
"REACTOME:R-MMU-9020591",
"REACTOME:R-MMU-9020933",
"REACTOME:R-SSC-9020591",
"REACTOME:R-SSC-9020933"
] | 8 | [
"1f42",
"1f45",
"3d85",
"3d87",
"3duh",
"3hmx",
"3qwr",
"4grw",
"5mj3",
"5mj4",
"5mxa",
"5mzv",
"5njd",
"6sff",
"6smc",
"6sp3",
"6uib",
"6wdq",
"7pur",
"7r3n",
"8cr5",
"8cr6",
"8cr8",
"8odz",
"8oe0",
"8oe4",
"8pb1",
"8uui",
"8xrp",
"8yi7"
] | 30 | [
"PUB00013064",
"PUB00043736",
"PUB00043737"
] | [
"11114383",
"10426995",
"18490716"
] | [
"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.",
"Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.",
"Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway."
] | [
2000,
1999,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1304
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
18,
1,
2,
4
] | 4 | true | Family | Interleukin-12 beta | Interleukin-12 beta | IL-12_beta | 3 |
IPR015529 | 15,529 | Interleukin-18 | IL-18 | Family | 743 | false | false | Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-18 (IL-18) is a potent proinflammatory cytokine that induces interferon-gamma (IFN-gamma) produ... | [] | [] | [] | 0 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF015162",
"PR01933"
] | [
"Interleukin_18",
"INTRLEUKIN18"
] | [
679,
706
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-448706",
"R-BTA-5620971",
"R-BTA-9012546",
"R-HSA-448706",
"R-HSA-5620971",
"R-HSA-6783783",
"R-HSA-6785807",
"R-HSA-9012546",
"R-HSA-9660826",
"R-MMU-448706",
"R-MMU-5620971",
"R-MMU-9012546",
"R-RNO-448706",
"R-RNO-5620971",
"R-RNO-9012546",
"R-SSC-448706",
"R-SSC-5620971",
... | [
"REACTOME:R-BTA-448706",
"REACTOME:R-BTA-5620971",
"REACTOME:R-BTA-9012546",
"REACTOME:R-HSA-448706",
"REACTOME:R-HSA-5620971",
"REACTOME:R-HSA-6783783",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-9012546",
"REACTOME:R-HSA-9660826",
"REACTOME:R-MMU-448706",
"REACTOME:R-MMU-5620971",
"REACTOME:R... | 18 | [
"1j0s",
"2vxt",
"3f62",
"3wo2",
"3wo3",
"3wo4",
"4eee",
"4ekx",
"4hjj",
"4r6u",
"4xfs",
"4xft",
"4xfu",
"7al7",
"8j6k",
"8spb",
"8sv1",
"8urv",
"9od7",
"9od9"
] | 20 | [
"PUB00026216",
"PUB00034867",
"PUB00034868",
"PUB00034869"
] | [
"14528293",
"14744554",
"15464021",
"15174967"
] | [
"The structure and binding mode of interleukin-18.",
"A potential role of interleukin 18 in severe falciparum malaria.",
"Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory intervention.",
"Therapeutic potential of targeting IL-1 and IL-18 in inflammation."
] | [
2003,
2004,
2004,
2004
] | 4 | [
"IPR000975"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
743
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
6,
4
] | 3 | true | Family | Interleukin-18 | Interleukin-18 | IL-18 | 8 |
IPR015550 | 15,550 | Glucagon | Glucagon | Family | 1,286 | false | false | A number of polypeptidic hormones, mainly expressed in the intestine or the pancreas, belong to a group of structurally related peptides [ , ]. Once such hormone, glucagon is widely distributed and produced in the alpha-cells of pancreatic islets [ ]. It affects glucose metabolism in the liver [ ] by inhibiting glycoge... | [
"GO:0005179"
] | [
"hormone activity"
] | [
"molecular_function"
] | 1 | [
"PANTHER"
] | [
"PTHR11418"
] | [
""
] | [
1286
] | 1 | [
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp2087",
"GenProp2089",
"GenProp2092",
"R-BTA-163359",
"R-BTA-381676",
"R-BTA-381771",
"R-BTA-416476",
"R-BTA-418555",
"R-BTA-420092",
"R-BTA-422085",
"R-GGA-163359",
"R-GGA-381771",
"R-GGA-416476",
"R-GGA-418555",
"R-GGA-420092",
"R-GGA-422085",
"R-HSA-163359",
"R-HSA-381676... | [
"GP:GenProp2087",
"GP:GenProp2089",
"GP:GenProp2092",
"REACTOME:R-BTA-163359",
"REACTOME:R-BTA-381676",
"REACTOME:R-BTA-381771",
"REACTOME:R-BTA-416476",
"REACTOME:R-BTA-418555",
"REACTOME:R-BTA-420092",
"REACTOME:R-BTA-422085",
"REACTOME:R-GGA-163359",
"REACTOME:R-GGA-381771",
"REACTOME:R-G... | 43 | [
"1bh0",
"1d0r",
"1gcn",
"1kx6",
"1nau",
"2g49",
"2l63",
"2l64",
"2m5p",
"2m5q",
"3iol",
"4apd",
"4zgm",
"5otu",
"5otv",
"5otw",
"5otx",
"5vai",
"5yqz",
"6eds",
"6lmk",
"6lml",
"6nzn",
"6phi",
"6phj",
"6phk",
"6phl",
"6phm",
"6phn",
"6pho",
"6php",
"6phq"... | 56 | [
"PUB00000024",
"PUB00000025",
"PUB00001745",
"PUB00002491",
"PUB00004603",
"PUB00088953"
] | [
"3133967",
"3291691",
"4076759",
"3260236",
"6577439",
"17167473"
] | [
"Vasoactive intestinal polypeptide and related peptides. Isolation and chemistry.",
"Glucagon and related peptides. Molecular structure and biological specificity.",
"Primary structure of glucagon from an elasmobranchian fish. Torpedo marmorata.",
"Isolation of peptide hormones from the pancreas of the bullfr... | [
1988,
1988,
1985,
1988,
1983,
2006
] | 6 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1286
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
2,
3
] | 4 | true | Family | Glucagon | Glucagon | Glucagon | 5 |
IPR015556 | 15,556 | Plasminogen activator inhibitor-2 | PAI-2 | Family | 61 | false | false | Plasminogen activator inhibitor 2 (PAI-2; MEROPS identifier I04.007) is a serpin (SERine Proteinase INhibitor). Serpins belong to MEROPS inhibitor family I4 (clan ID) [ ]. PAI-2 has antiapoptosis activity, probably related to its interaction with the proteasome subunit PSMbeta1 [ ]. PAI-2 might be an important factor i... | [
"GO:0004867",
"GO:0043066"
] | [
"serine-type endopeptidase inhibitor activity",
"negative regulation of apoptotic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"CDD"
] | [
"cd19562"
] | [
"serpinB2_PAI-2"
] | [
61
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-75205",
"R-HSA-8950505",
"R-MMU-75205",
"R-RNO-75205"
] | [
"REACTOME:R-HSA-75205",
"REACTOME:R-HSA-8950505",
"REACTOME:R-MMU-75205",
"REACTOME:R-RNO-75205"
] | 4 | [
"1by7",
"1jrr",
"2arq",
"2arr"
] | 4 | [
"PUB00014133",
"PUB00021278",
"PUB00067573",
"PUB00067574"
] | [
"14705960",
"10368272",
"14732874",
"7499264"
] | [
"Evolutionary families of peptidase inhibitors.",
"The crystal structure of plasminogen activator inhibitor 2 at 2.0 A resolution: implications for serpin function.",
"Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1.",
"Plasminogen activator inhibitor type 2 inhibits tumor... | [
2004,
1999,
2004,
1995
] | 4 | [] | [] | 0 | 0 | null | [
"Boreoeutheria"
] | [
61
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
2
] | 3 | true | Family | Plasminogen activator inhibitor-2 | Plasminogen activator inhibitor-2 | PAI-2 | 3 |
IPR015576 | 15,576 | Spermine synthase, animal | Spermine_synthase_animal | Family | 1,759 | false | false | The polyamines putrescine, spermidine and spermine represent a group of naturally occurring compounds exerting a bewildering number of biological effects. Their biosynthesis is accomplished by a concerted action of four different enzymes: ornithine decarboxylase, adenosylmethionine decarboxylase, spermidine synthase an... | [
"GO:0016768",
"GO:0006597"
] | [
"spermine synthase activity",
"spermine biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR46315"
] | [
""
] | [
1759
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.5.1.22",
"R-BTA-351202",
"R-HSA-351202",
"R-MMU-351202"
] | [
"EC:2.5.1.22",
"REACTOME:R-BTA-351202",
"REACTOME:R-HSA-351202",
"REACTOME:R-MMU-351202"
] | 4 | [
"3c6k",
"3c6m"
] | 2 | [
"PUB00034968",
"PUB00034969",
"PUB00034970"
] | [
"1930914",
"9467015",
"7546290"
] | [
"Polyamines: from molecular biology to clinical applications.",
"Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene.",
"Molecular cloning of a cDNA encoding human spermine synthase."
] | [
1991,
1998,
1995
] | 3 | [
"IPR001045"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Opisthokonta"
] | [
21,
1738
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
3,
3,
5
] | 5 | true | Family | Spermine synthase, animal | Spermine synthase, animal | Spermine_synthase_animal | 7 |
IPR015578 | 15,578 | Neurotrophin-3 | Neurotrophin-3 | Family | 3,256 | false | false | During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells [ ]. Such cells control their degree of innervation (... | [
"GO:0005165"
] | [
"neurotrophin receptor binding"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01914"
] | [
"NEUROTROPHN3"
] | [
3256
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1257604",
"R-BTA-6811558",
"R-BTA-9034013",
"R-BTA-9034793",
"R-BTA-9603381",
"R-HSA-1257604",
"R-HSA-2219530",
"R-HSA-6811558",
"R-HSA-9025046",
"R-HSA-9034013",
"R-HSA-9034015",
"R-HSA-9034793",
"R-HSA-9034864",
"R-HSA-9603381",
"R-MMU-1257604",
"R-MMU-6811558",
"R-MMU-90340... | [
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-6811558",
"REACTOME:R-BTA-9034013",
"REACTOME:R-BTA-9034793",
"REACTOME:R-BTA-9603381",
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA-2219530",
"REACTOME:R-HSA-6811558",
"REACTOME:R-HSA-9025046",
"REACTOME:R-HSA-9034013",
"REACTOME:R-HSA-9034015",
"REACTOM... | 24 | [] | 0 | [
"PUB00000638",
"PUB00001187",
"PUB00001600",
"PUB00005102",
"PUB00005408",
"PUB00034812",
"PUB00034813",
"PUB00034814",
"PUB00034815",
"PUB00034816"
] | [
"1477101",
"2369898",
"1995338",
"3589669",
"8488558",
"2321006",
"12914971",
"14507970",
"14499950",
"14519521"
] | [
"Purification and amino-acid sequence of a nerve growth factor from the venom of Vipera russelli russelli.",
"Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.",
"Amino acid sequences of nerve growth factors derived from cobra venoms.",
"Recruitment of enzymes as lens s... | [
1992,
1990,
1991,
1987,
1993,
1990,
2003,
2003,
2003,
2003
] | 10 | [
"IPR020408"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
3256
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
1,
2,
5
] | 4 | true | Family | Neurotrophin-3 | Neurotrophin-3 | Neurotrophin-3 | 9 |
IPR015590 | 15,590 | Aldehyde dehydrogenase domain | Aldehyde_DH_dom | Domain | 404,013 | false | false | Aldehyde dehydrogenases ( and ) are enzymes that oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least four different forms of the enzyme are known [ ]: class-1 (or Ald C) a tetrameric cytosolic enzyme, class-2 (or Ald M) a tetrameric mitochondrial enzyme, class- 3 (or... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00171"
] | [
"Aldedh"
] | [
404013
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"1.2.1",
"GenProp0292",
"GenProp0294",
"GenProp0457",
"GenProp0715",
"GenProp0717",
"GenProp1226",
"GenProp1267",
"GenProp1276",
"GenProp1297",
"GenProp1321",
"GenProp1370",
"GenProp1379",
"GenProp1390",
"GenProp1401",
"GenProp1402",
"GenProp1425",
"GenProp1434",
"GenProp1437",
... | [
"EC:1.2.1",
"GP:GenProp0292",
"GP:GenProp0294",
"GP:GenProp0457",
"GP:GenProp0715",
"GP:GenProp0717",
"GP:GenProp1226",
"GP:GenProp1267",
"GP:GenProp1276",
"GP:GenProp1297",
"GP:GenProp1321",
"GP:GenProp1370",
"GP:GenProp1379",
"GP:GenProp1390",
"GP:GenProp1401",
"GP:GenProp1402",
"G... | 156 | [
"1a4s",
"1a4z",
"1ad3",
"1ag8",
"1bi9",
"1bpw",
"1bxs",
"1cw3",
"1euh",
"1eyy",
"1ez0",
"1ky8",
"1nzw",
"1nzx",
"1nzz",
"1o00",
"1o01",
"1o02",
"1o04",
"1o05",
"1o20",
"1o9j",
"1qi1",
"1qi6",
"1t90",
"1uxn",
"1uxp",
"1uxq",
"1uxr",
"1uxt",
"1uxu",
"1uxv"... | 522 | [
"PUB00000303",
"PUB00015186"
] | [
"2713359",
"7920024"
] | [
"Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver: distant relationship to the class 1 and 2 enzymes from mammalian liver cytosol/mitochondria.",
"Allergen nomenclature. WHO/IUIS Allergen Nomenclature Subcommittee."
] | [
1989,
1994
] | 2 | [] | [
"IPR000965",
"IPR005933",
"IPR044086",
"IPR044148"
] | 0 | 4 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
3550,
302042,
93798,
3,
6,
4614
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
75,
24,
49,
48,
14,
138,
77,
15,
81,
110,
10,
8,
221
] | 13 | true | Domain | Aldehyde dehydrogenase domain | Aldehyde dehydrogenase domain | Aldehyde_DH_dom | 1 |
IPR015615 | 15,615 | Transforming growth factor-beta-like | TGF-beta-like | Family | 36,105 | false | false | The transforming growth factor-beta (TGF-beta) superfamily comprises a number of structurally related, secreted polypeptides that regulate a multitude of cellular processes including proliferation, differentiation, cell invasion, immune regulation, and neoplastic transformation [ , ]. Family members include the activin... | [
"GO:0005576"
] | [
"extracellular region"
] | [
"cellular_component"
] | 1 | [
"PANTHER"
] | [
"PTHR11848"
] | [
""
] | [
36105
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-1502540",
"R-BTA-201451",
"R-BTA-209822",
"R-BTA-2129379",
"R-BTA-2173789",
"R-BTA-2473224",
"R-BTA-381426",
"R-BTA-8957275",
"R-BTA-9839389",
"R-BTA-9839406",
"R-CEL-114608",
"R-CEL-201451",
"R-CEL-2129379",
"R-CEL-2173788",
"R-CEL-2173789",
"R-CEL-2173791",
... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-1502540",
"REACTOME:R-BTA-201451",
"REACTOME:R-BTA-209822",
"REACTOME:R-BTA-2129379",
"REACTOME:R-BTA-2173789",
"REACTOME:R-BTA-2473224",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-8957275",
"REACTOME:R-BTA-9839389",
"REACTOME:R-BTA-9839406",
"REACTOME:R-... | 134 | [
"1bmp",
"1es7",
"1kla",
"1klc",
"1kld",
"1ktz",
"1lx5",
"1lxi",
"1m4u",
"1nys",
"1nyu",
"1reu",
"1rew",
"1s4y",
"1tfg",
"1tgj",
"1tgk",
"1waq",
"1zkz",
"2arp",
"2arv",
"2b0u",
"2bhk",
"2goo",
"2h62",
"2h64",
"2p6a",
"2pjy",
"2qcq",
"2qcw",
"2qj9",
"2qja"... | 152 | [
"PUB00000211",
"PUB00004939",
"PUB00005153",
"PUB00007614",
"PUB00035159",
"PUB00035160",
"PUB00043835",
"PUB00096668",
"PUB00096669",
"PUB00097278"
] | [
"1575734",
"8199356",
"1631557",
"8679613",
"15032667",
"15180456",
"18662538",
"29109152",
"30696809",
"24086041"
] | [
"Evolutionary grouping of the transforming growth factor-beta superfamily.",
"Evolution of the transforming growth factor-beta superfamily.",
"Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily.",
"Transforming growth factor beta 1: three-dimensional structure in solut... | [
1992,
1994,
1992,
1996,
2004,
2004,
2008,
2018,
2019,
2013
] | 10 | [] | [
"IPR000491",
"IPR001318",
"IPR003942",
"IPR016319",
"IPR017175",
"IPR017197"
] | 0 | 6 | 0 | [
"Bacteria",
"Chordopoxvirinae",
"Eukaryota",
"bird metagenome"
] | [
10,
24,
36070,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
96,
11,
128,
82,
91
] | 6 | true | Family | Transforming growth factor-beta-like | Transforming growth factor-beta-like | TGF-beta-like | 5 |
IPR015616 | 15,616 | Growth/differentiation factor 8, C-terminal domain | GDF8_C | Domain | 1,639 | false | false | This entry represents Growth/differentiation factor 8. Growth and differentiation 8 (GDF-8), or myostatin, is a member of this superfamily with a role in the control and maintenance of skeletal muscle mass. Myostatin knockout in mice increases myogenesis and decreases adipogenesis [ ]. Frequent sequence variation in th... | [
"GO:0005102",
"GO:0008083"
] | [
"signaling receptor binding",
"growth factor activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"CDD"
] | [
"cd19388"
] | [
"TGF_beta_GDF8"
] | [
1639
] | 1 | [
"REACTOME"
] | [
"R-HSA-9617828"
] | [
"REACTOME:R-HSA-9617828"
] | 1 | [
"3hh2",
"3sek",
"5f3b",
"5f3h",
"5ji1",
"5ntu",
"5nxs",
"6umx"
] | 8 | [
"PUB00000211",
"PUB00004939",
"PUB00005153",
"PUB00007614",
"PUB00035159",
"PUB00035160",
"PUB00035187",
"PUB00035188",
"PUB00043835",
"PUB00096668",
"PUB00096669",
"PUB00097278"
] | [
"1575734",
"8199356",
"1631557",
"8679613",
"15032667",
"15180456",
"11855847",
"10610713",
"18662538",
"29109152",
"30696809",
"24086041"
] | [
"Evolutionary grouping of the transforming growth factor-beta superfamily.",
"Evolution of the transforming growth factor-beta superfamily.",
"Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily.",
"Transforming growth factor beta 1: three-dimensional structure in solut... | [
1992,
1994,
1992,
1996,
2004,
2004,
2002,
1999,
2008,
2018,
2019,
2013
] | 12 | [
"IPR001839"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
1639
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
11,
5,
3
] | 4 | true | Domain | Growth/differentiation factor 8, C-terminal domain | Growth/differentiation factor 8, C-terminal domain | GDF8_C | 1 |
IPR015618 | 15,618 | Transforming growth factor beta-3 | TGFB3 | Family | 1,052 | false | false | The transforming growth factors-beta (TGF-beta 1-5) constitute of a family of multi-functional cytokines that regulate cell growth and differentiation [ ]. Many cells synthesise TGF-beta, and essentially all have specific receptors for this peptide [ ]. TGF-beta regulates the actions of many other peptide growth factor... | [
"GO:0005160"
] | [
"transforming growth factor beta receptor binding"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01426"
] | [
"TGFBETA3"
] | [
1052
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-114608",
"R-HSA-2129379",
"R-HSA-2173789",
"R-HSA-3000178",
"R-MMU-114608",
"R-MMU-2129379",
"R-MMU-2173789",
"R-RNO-114608",
"R-RNO-2129379",
"R-RNO-2173789",
"R-SSC-114608",
"R-SSC-2129379",
"R-SSC-2173789"
] | [
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-2129379",
"REACTOME:R-HSA-2173789",
"REACTOME:R-HSA-3000178",
"REACTOME:R-MMU-114608",
"REACTOME:R-MMU-2129379",
"REACTOME:R-MMU-2173789",
"REACTOME:R-RNO-114608",
"REACTOME:R-RNO-2129379",
"REACTOME:R-RNO-2173789",
"REACTOME:R-SSC-114608",
"REACTOME:R-... | 13 | [
"8vs6",
"8vsb"
] | 2 | [
"PUB00007611",
"PUB00007612",
"PUB00007613",
"PUB00007628",
"PUB00007629"
] | [
"8424942",
"2879635",
"8819159",
"2628730",
"7852342"
] | [
"Transforming growth factor beta 1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells.",
"The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors.",
"The crystal structure of TGF-beta 3 and compar... | [
1993,
1987,
1996,
1989,
1995
] | 5 | [
"IPR016319"
] | [] | 1 | 0 | 1 | [
"Chordata"
] | [
1052
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
7,
3
] | 4 | true | Family | Transforming growth factor beta-3 | Transforming growth factor beta-3 | TGFB3 | 2 |
IPR015621 | 15,621 | Interleukin-1 receptor family | IL-1_rcpt_fam | Family | 11,915 | false | false | Interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis [ ]. Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and dif... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR11890"
] | [
""
] | [
11915
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DRE-9007892",
"R-HSA-1257604",
"R-HSA-166058",
"R-HSA-2132295",
"R-HSA-388844",
"R-HSA-6783783",
"R-HSA-6811558",
"R-HSA-9007892",
"R-HSA-9008059",
"R-HSA-9012546",
"R-HSA-9014826",
"R-HSA-9014843",
"R-HSA-9020702",
"R-HSA-9679191",
"R-MMU-1257604",
"R-MMU-2132295",
"R-MMU-388844"... | [
"REACTOME:R-DRE-9007892",
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA-166058",
"REACTOME:R-HSA-2132295",
"REACTOME:R-HSA-388844",
"REACTOME:R-HSA-6783783",
"REACTOME:R-HSA-6811558",
"REACTOME:R-HSA-9007892",
"REACTOME:R-HSA-9008059",
"REACTOME:R-HSA-9012546",
"REACTOME:R-HSA-9014826",
"REACTOME:... | 31 | [
"1g0y",
"1ira",
"1itb",
"1t3g",
"3o4o",
"3oq3",
"3wo3",
"3wo4",
"4dep",
"4gaf",
"4kc3",
"4r6u",
"4yfd",
"4yh6",
"4yh7",
"5vi4",
"5wy8",
"5y32",
"6kn9",
"6u6u",
"7fcc",
"7fch",
"7fcj",
"7fcl",
"7fd3",
"7szl",
"7tze",
"7tzg",
"8dgg",
"8so3",
"8sr0",
"9bf9"... | 36 | [
"PUB00007346",
"PUB00007347",
"PUB00007348",
"PUB00007351"
] | [
"2969618",
"8702856",
"1833184",
"9062194"
] | [
"cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.",
"Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA.",
"A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.",
"A new c... | [
1988,
1996,
1991,
1997
] | 4 | [] | [
"IPR004074"
] | 0 | 1 | 0 | [
"Chordopoxvirinae",
"Metazoa"
] | [
265,
11650
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
46,
49,
36,
64
] | 4 | true | Family | Interleukin-1 receptor family | Interleukin-1 receptor family | IL-1_rcpt_fam | 1 |
IPR015631 | 15,631 | CD2/SLAM family receptor | CD2/SLAM_rcpt | Family | 12,751 | false | false | The SLAM/CD2 family of receptors plays important roles in regulating multiple cellular interactions in the adaptive and innate immune systems [ ]. Signalling lymphocyte activation molecule (SLAM) receptors are expressed in multiple cells of the immune system, including natural killer cells, T cells, and B cells [ , , ,... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PANTHER"
] | [
"PTHR12080"
] | [
""
] | [
12751
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-198933",
"R-HSA-202733",
"R-HSA-6798695",
"R-MMU-198933",
"R-MMU-202733",
"R-RNO-202733"
] | [
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-198933",
"REACTOME:R-MMU-202733",
"REACTOME:R-RNO-202733"
] | 6 | [
"1ccz",
"1ci5",
"1hnf",
"1hng",
"1qa9",
"2dru",
"2edo",
"2if7",
"2pkd",
"2ptt",
"2ptv"
] | 11 | [
"PUB00034934",
"PUB00034935",
"PUB00090162",
"PUB00155119",
"PUB00155120",
"PUB00155121",
"PUB00155122"
] | [
"12787752",
"11034354",
"21094032",
"20818396",
"22184727",
"27249817",
"27683913"
] | [
"The SLAM family of immune-cell receptors.",
"Defective NK cell activation in X-linked lymphoproliferative disease.",
"The role of SLAM/CD2 polymorphisms in systemic autoimmunity.",
"SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages.",
"Increased expression of SLAM recep... | [
2003,
2000,
2010,
2010,
2012,
2016,
2016
] | 7 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"Viruses"
] | [
12717,
34
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
73,
40,
58,
37
] | 4 | true | Family | CD2/SLAM family receptor | CD2/SLAM family receptor | CD2/SLAM_rcpt | 4 |
IPR015632 | 15,632 | T-cell surface antigen CD2 | CD2 | Family | 368 | false | false | The CD2 adhesion molecule is a cell surface protein expressed by T cells and natural killer cells. CD2's extracellular domain contains immunoglobulin-like domains that are glycosylated at two sites and can mediate homodimerisation [ ]. Ligation of CD2 by CD58 in humans or CD48 in mice helps T cells adhere to antigen-pr... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01870"
] | [
"CD2ANTIGEN"
] | [
368
] | 1 | [
"REACTOME"
] | [
"R-HSA-202733"
] | [
"REACTOME:R-HSA-202733"
] | 1 | [
"1a64",
"1a6p",
"1a7b",
"1cdb",
"1cdc",
"1gya",
"1hnf",
"1hng",
"1qa9",
"1t6w"
] | 10 | [
"PUB00034961",
"PUB00034962",
"PUB00034963"
] | [
"12475217",
"1358605",
"9794375"
] | [
"The pH dependence of CD2 domain 1 self-association and 15N chemical exchange broadening is correlated with the anomalous pKa of Glu41.",
"Development and function of T cells in mice with a disrupted CD2 gene.",
"Uncoupling activation-dependent HS1 phosphorylation from nuclear factor of activated T cells transc... | [
2002,
1992,
1998
] | 3 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
368
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
2
] | 3 | true | Family | T-cell surface antigen CD2 | T-cell surface antigen CD2 | CD2 | 1 |
IPR015633 | 15,633 | E2F Family | E2F | Family | 14,379 | false | false | The E2F family of transcription factors plays a crucial role in the control of cell cycle [ , ] and action of tumour suppressor proteins. This family consists of eight members and is divided into activators (E2F1-3) and repressors (E2F4-8) depending on cellular context, target gene and cofactors [ ]. The E2F proteins c... | [
"GO:0000978",
"GO:0006357"
] | [
"RNA polymerase II cis-regulatory region sequence-specific DNA binding",
"regulation of transcription by RNA polymerase II"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR12081"
] | [
""
] | [
14379
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-8953750",
"R-DME-1538133",
"R-DME-2173796",
"R-DME-68911",
"R-DME-69231",
"R-DME-8953750",
"R-DRE-6804116",
"R-HSA-111448",
"R-HSA-113501",
"R-HSA-1362277",
"R-HSA-1362300",
"R-HSA-139915",
"R-HSA-1538133",
"R-HSA-1912408",
"R-HSA-2173796",
"R-HSA-2559580",
"R-HSA-2559585",
... | [
"REACTOME:R-BTA-8953750",
"REACTOME:R-DME-1538133",
"REACTOME:R-DME-2173796",
"REACTOME:R-DME-68911",
"REACTOME:R-DME-69231",
"REACTOME:R-DME-8953750",
"REACTOME:R-DRE-6804116",
"REACTOME:R-HSA-111448",
"REACTOME:R-HSA-113501",
"REACTOME:R-HSA-1362277",
"REACTOME:R-HSA-1362300",
"REACTOME:R-HS... | 38 | [
"1cf7",
"2aze",
"4yo2",
"5tuu",
"5tuv"
] | 5 | [
"PUB00008097",
"PUB00096666",
"PUB00096667"
] | [
"7739537",
"22903062",
"20040599"
] | [
"In vivo association of E2F and DP family proteins.",
"E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1.",
"Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B."
] | [
1995,
2012,
2010
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
14377,
2
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
29,
3,
17,
5,
28,
24,
21,
25,
59
] | 9 | true | Family | E2F Family | E2F Family | E2F | 6 |
IPR015637 | 15,637 | Uracil DNA glycosylase family 2 | MUG/TDG | Family | 9,586 | false | false | G:U mismatches resulting from deamination of cytosine are the most common pro-mutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises uracil from both single- and double-stranded DNA. The uracil DNA glycosylase family 2 consists of thymine D... | [
"GO:0000700",
"GO:0006285"
] | [
"mismatch base pair DNA N-glycosylase activity",
"base-excision repair, AP site formation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER",
"CDD"
] | [
"PTHR12159",
"cd10028"
] | [
"",
"UDG-F2_TDG_MUG"
] | [
9536,
9268
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.2.2.28",
"R-HSA-110328",
"R-HSA-110329",
"R-HSA-110357",
"R-HSA-3108214",
"R-HSA-5221030",
"R-MMU-110329",
"R-MMU-110357",
"R-MMU-3108214",
"R-MMU-5221030",
"R-SPO-110329",
"R-SPO-3108214",
"R-SPO-5221030"
] | [
"EC:3.2.2.28",
"REACTOME:R-HSA-110328",
"REACTOME:R-HSA-110329",
"REACTOME:R-HSA-110357",
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-5221030",
"REACTOME:R-MMU-110329",
"REACTOME:R-MMU-110357",
"REACTOME:R-MMU-3108214",
"REACTOME:R-MMU-5221030",
"REACTOME:R-SPO-110329",
"REACTOME:R-SPO-3108214",... | 13 | [
"1mtl",
"1mug",
"1mwi",
"1mwj",
"1wyw",
"2c2p",
"2c2q",
"2d07",
"2rba",
"3ufj",
"3uo7",
"3uob",
"4fnc",
"4jgc",
"4xeg",
"4z3a",
"4z47",
"4z7b",
"4z7z",
"5cys",
"5ff8",
"5hf7",
"5jxy",
"5t2w",
"6u15",
"6u16",
"6u17"
] | 27 | [
"PUB00008091",
"PUB00080609",
"PUB00095804"
] | [
"9489705",
"19909758",
"18789404"
] | [
"Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions.",
"Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition.",
"Repair of deaminated base damage by Schizosaccharomyces pombe thymine DNA glyc... | [
1998,
2010,
2008
] | 3 | [] | [
"IPR003310",
"IPR023502"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Peduoviridae",
"metagenomes"
] | [
10,
5503,
4020,
2,
51
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
7,
3,
1,
10,
6,
1,
8,
1
] | 8 | true | Family | Uracil DNA glycosylase family 2 | Uracil DNA glycosylase family 2 | MUG/TDG | 8 |
IPR015646 | 15,646 | Nuclear factor of activated T-cells 5, Rel homology domain, DNA-binding domain | NFAT5_RHD_DNA-bd | Domain | 1,825 | false | false | Nuclear factor of activated T-cells 5 (NFAT5) is a member of the nuclear factors of activated T cells (NFAT) of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mam... | [
"GO:0000978"
] | [
"RNA polymerase II cis-regulatory region sequence-specific DNA binding"
] | [
"molecular_function"
] | 1 | [
"CDD"
] | [
"cd07882"
] | [
"RHD-n_TonEBP"
] | [
1825
] | 1 | [] | [] | [] | 0 | [
"1imh"
] | 1 | [
"PUB00004201",
"PUB00011687",
"PUB00035152",
"PUB00049544",
"PUB00095357"
] | [
"7830764",
"10652349",
"11528118",
"17869269",
"22266867"
] | [
"Structure of the NF-kappa B p50 homodimer bound to DNA.",
"Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization.",
"Genomic organization of the human NFAT5 gene: exon-intron structure of the 14-kb transcript and CpG-island analysis of the promot... | [
1995,
2000,
2001,
2007,
2012
] | 5 | [
"IPR011539"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1825
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
8,
1,
6,
4
] | 5 | true | Domain | Nuclear factor of activated T-cells 5, Rel homology domain, DNA-binding domain | Nuclear factor of activated T-cells 5, Rel homology domain, DNA-binding domain | NFAT5_RHD_DNA-bd | 5 |
IPR015648 | 15,648 | Transcription factor DP | Transcrpt_fac_DP | Family | 5,702 | false | false | The DP proteins function as binding partners for E2F transcription factors. The association of DP with E2F can either enhances or repress E2F-dependent transcriptional activity. The activities of both DP and E2F proteins are under cell cycle control, being influenced by the level of phosphorylation imparted through the... | [
"GO:0051726",
"GO:0005667"
] | [
"regulation of cell cycle",
"transcription regulator complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF009404",
"PTHR12548"
] | [
"Transcription_factor_DP",
""
] | [
3665,
5702
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1538133",
"R-BTA-2173796",
"R-BTA-69231",
"R-BTA-8953750",
"R-CEL-1538133",
"R-CEL-2173796",
"R-DME-1538133",
"R-DME-2173796",
"R-DME-69231",
"R-DME-8953750",
"R-HSA-111448",
"R-HSA-113501",
"R-HSA-1362277",
"R-HSA-1362300",
"R-HSA-139915",
"R-HSA-1538133",
"R-HSA-1912408",
... | [
"REACTOME:R-BTA-1538133",
"REACTOME:R-BTA-2173796",
"REACTOME:R-BTA-69231",
"REACTOME:R-BTA-8953750",
"REACTOME:R-CEL-1538133",
"REACTOME:R-CEL-2173796",
"REACTOME:R-DME-1538133",
"REACTOME:R-DME-2173796",
"REACTOME:R-DME-69231",
"REACTOME:R-DME-8953750",
"REACTOME:R-HSA-111448",
"REACTOME:R-H... | 32 | [
"1cf7",
"2aze",
"5tuu",
"5tuv"
] | 4 | [
"PUB00035117",
"PUB00035118",
"PUB00035119"
] | [
"8674727",
"9670325",
"7880534"
] | [
"E2F and the molecular mechanisms of early cell-cycle control.",
"Growth regulation by the E2F and DP transcription factor families.",
"DP and E2F proteins: coordinating transcription with cell cycle progression."
] | [
1996,
1998,
1994
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5702
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
1,
4,
2,
11,
22,
10,
16,
19
] | 9 | true | Family | Transcription factor DP | Transcription factor DP | Transcrpt_fac_DP | 7 |
IPR015654 | 15,654 | Mandelate racemase | Mandelate_racemase | Family | 8 | false | false | Mandelate racemase ( ) (MR) in certain bacteria, including Pseudomonas putida, utilise D or L mandelic acid as sole carbon source for energy. Mandelate racemase and muconate lactonizing enzyme ( ) (MLE) are two bacterial enzymes involved in aromatic acid catabolism. They catalyze mechanistically distinct reactions yet ... | [
"GO:0018838"
] | [
"mandelate racemase activity"
] | [
"molecular_function"
] | 1 | [
"SFLD"
] | [
"SFLDF00004"
] | [
"mandelate_racemase"
] | [
8
] | 1 | [] | [] | [] | 0 | [
"1mdr",
"1mns",
"2mnr",
"3uxk",
"3uxl",
"4fp1",
"4m6u",
"4x2p",
"6vim",
"7mqx"
] | 10 | [
"PUB00004081",
"PUB00005404",
"PUB00034787"
] | [
"2215699",
"8256284",
"1892834"
] | [
"Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous.",
"On the origin of enzymatic species.",
"Mechanism of the reaction catalyzed by mandelate racemase. 2. Crystal structure of mandelate racemase at 2.5-A resolution: identification of the active site and... | [
1990,
1993,
1991
] | 3 | [
"IPR046945"
] | [] | 1 | 0 | 1 | [
"Pseudomonadota"
] | [
8
] | 1 | [] | [] | 0 | true | Family | Mandelate racemase | Mandelate racemase | Mandelate_racemase | 6 |
IPR015655 | 15,655 | Protein phosphatase 2C | PP2C | Family | 110,598 | false | false | Protein phosphatase 2C (PP2C) is one of the four major classes of mammalian serine/threonine specific protein phosphatases ( ). PP2C [ ] is a monomeric enzyme of about 42kDa, that shows broad substrate specificity and is dependent on divalent cations (mainly manganese and magnesium) for its activity. The exact physiolo... | [
"GO:0004722",
"GO:0006470"
] | [
"protein serine/threonine phosphatase activity",
"protein dephosphorylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER",
"PANTHER"
] | [
"PTHR13832",
"PTHR47992"
] | [
"",
""
] | [
45661,
64937
] | 2 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"3.1.3",
"3.1.3.16",
"R-BTA-1169408",
"R-BTA-204174",
"R-BTA-2173795",
"R-BTA-380972",
"R-BTA-70895",
"R-CEL-1169408",
"R-CEL-2173795",
"R-CEL-380972",
"R-HSA-1169408",
"R-HSA-1660661",
"R-HSA-168638",
"R-HSA-204174",
"R-HSA-2173795",
"R-HSA-2871837",
"R-HSA-380972",
"R-HSA-445989"... | [
"EC:3.1.3",
"EC:3.1.3.16",
"REACTOME:R-BTA-1169408",
"REACTOME:R-BTA-204174",
"REACTOME:R-BTA-2173795",
"REACTOME:R-BTA-380972",
"REACTOME:R-BTA-70895",
"REACTOME:R-CEL-1169408",
"REACTOME:R-CEL-2173795",
"REACTOME:R-CEL-380972",
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-1660661",
"REACTOME:... | 60 | [
"1a6q",
"1txo",
"2cm1",
"2i0o",
"2i44",
"2iq1",
"2irm",
"2isn",
"2j4o",
"2j82",
"2j86",
"2jfr",
"2jfs",
"2jft",
"2p8e",
"2pk0",
"2pnq",
"2pom",
"2pop",
"2v06",
"2xzv",
"2y09",
"3d8k",
"3fxj",
"3fxk",
"3fxl",
"3fxm",
"3fxo",
"3jrq",
"3kb3",
"3kdj",
"3mq3"... | 108 | [
"PUB00000387",
"PUB00001629",
"PUB00003690",
"PUB00005194",
"PUB00155069",
"PUB00155070"
] | [
"8396421",
"1312947",
"8395005",
"7973632",
"11559703",
"18930133"
] | [
"Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C.",
"Molecular cloning and primary structure of a protein phosphatase 2C isoform.",
"Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein se... | [
1993,
1992,
1993,
1994,
2001,
2009
] | 6 | [] | [
"IPR016660"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
142,
19359,
90656,
89,
352
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
312,
9,
50,
28,
68,
49,
5,
181,
75,
6,
5,
598
] | 12 | true | Family | Protein phosphatase 2C | Protein phosphatase 2C | PP2C | 5 |
IPR015657 | 15,657 | Aminobutyraldehyde dehydrogenase | Aminobutyraldehyde_DH | Family | 6,379 | false | false | Aminobutyraldehyde dehydrogenase functions in the putrescine degradation pathway. It catalyses the oxidation of 4 aminobutyraldehyde to 4 aminobutyrate, a neurotransmitter. YdcW encodes gamma-aminobutyraldehyde dehydrogenase (ABALDH) in the wild-type Escherichia coli (strain K12). It is a tetramer and when coupled with... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd07092"
] | [
"ALDH_ABALDH-YdcW"
] | [
6379
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"1.2.1.-",
"1.2.1.19",
"PWY-1121",
"PWY-2",
"PWY-2724",
"PWY-282",
"PWY-3",
"PWY-3162",
"PWY-321",
"PWY-5168",
"PWY-5305",
"PWY-5875",
"PWY-5885",
"PWY-6309",
"PWY-6322",
"PWY-6328",
"PWY-6681",
"PWY-6713",
"PWY-6832",
"PWY-6863",
"PWY-6926",
"PWY-6948",
"PWY-7033",
"PW... | [
"EC:1.2.1.-",
"EC:1.2.1.19",
"METACYC:PWY-1121",
"METACYC:PWY-2",
"METACYC:PWY-2724",
"METACYC:PWY-282",
"METACYC:PWY-3",
"METACYC:PWY-3162",
"METACYC:PWY-321",
"METACYC:PWY-5168",
"METACYC:PWY-5305",
"METACYC:PWY-5875",
"METACYC:PWY-5885",
"METACYC:PWY-6309",
"METACYC:PWY-6322",
"META... | 34 | [
"1wnb",
"1wnd",
"4dal",
"4f3x",
"6c43"
] | 5 | [
"PUB00032275",
"PUB00042939",
"PUB00043488"
] | [
"15381418",
"16023116",
"12186751"
] | [
"Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase.",
"Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase.",
"Purification and characterization of aminobutyraldehyde dehydrogenase from Arthrobacter Sp.... | [
2004,
2005,
2002
] | 3 | [] | [
"IPR017749"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
6222,
6,
151
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Aminobutyraldehyde dehydrogenase | Aminobutyraldehyde dehydrogenase | Aminobutyraldehyde_DH | 4 |
IPR015659 | 15,659 | Proline oxidase family | Proline_oxidase | Family | 17,334 | false | false | This entry includes a group of proline dehydrogenases (proline oxidases) found in bacteria, archaea and eukaryotes (mitochondria). | [
"GO:0004657",
"GO:0006562"
] | [
"proline dehydrogenase activity",
"L-proline catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR13914"
] | [
""
] | [
17334
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.5.5.2",
"PWY-5737",
"PWY-6922",
"R-CEL-389661",
"R-CEL-70688",
"R-DDI-389661",
"R-DDI-70688",
"R-DME-389661",
"R-DME-70688",
"R-HSA-389661",
"R-HSA-70688",
"R-MMU-389661",
"R-MMU-70688",
"R-RNO-389661",
"R-RNO-70688",
"R-SCE-389661",
"R-SCE-70688",
"R-SPO-389661",
"R-SPO-70688... | [
"EC:1.5.5.2",
"METACYC:PWY-5737",
"METACYC:PWY-6922",
"REACTOME:R-CEL-389661",
"REACTOME:R-CEL-70688",
"REACTOME:R-DDI-389661",
"REACTOME:R-DDI-70688",
"REACTOME:R-DME-389661",
"REACTOME:R-DME-70688",
"REACTOME:R-HSA-389661",
"REACTOME:R-HSA-70688",
"REACTOME:R-MMU-389661",
"REACTOME:R-MMU-7... | 19 | [
"1tiw",
"1tj0",
"1tj1",
"1tj2",
"2ekg",
"2fzm",
"2fzn",
"2g37",
"3e2q",
"3e2r",
"3e2s",
"3itg",
"4h6q",
"4h6r",
"4o8a",
"5m42",
"7mwt",
"7mwu",
"7mwv",
"7sqn",
"8dko",
"8dkp",
"8dkq",
"8upz",
"8uq0",
"8uq1",
"8w0k",
"9c8a",
"9c8b",
"9d7l"
] | 30 | [
"PUB00083173",
"PUB00083174",
"PUB00085164"
] | [
"17536821",
"8096642",
"25697095"
] | [
"Delta1-pyrroline-5-carboxylic acid formed by proline dehydrogenase from the Bacillus subtilis ssp. natto expressed in Escherichia coli as a precursor for 2-acetyl-1-pyrroline.",
"The sluggish-A gene of Drosophila melanogaster is expressed in the nervous system and encodes proline oxidase, a mitochondrial enzyme ... | [
2007,
1993,
2015
] | 3 | [] | [
"IPR008219"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviricetes",
"unclassified sequences"
] | [
485,
8186,
8541,
5,
117
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
11,
1,
8,
4,
12,
11,
1,
4,
11,
1,
1,
6
] | 12 | true | Family | Proline oxidase family | Proline oxidase family | Proline_oxidase | 9 |
IPR015660 | 15,660 | Achaete-scute transcription factor-related | MASH1/Ascl1a-like | Family | 8,778 | false | false | Basic helix-loop-helix proteins (bHLH) are a group of eukaryotic transcription factors that exert a determinative influence in a variety of developmental pathways. These transcription factors are characterised by a highly evolutionary conserved bHLH domain that mediates specific dimerisation [ ]. They facilitate the co... | [
"GO:0003700",
"GO:0006357"
] | [
"DNA-binding transcription factor activity",
"regulation of transcription by RNA polymerase II"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR13935"
] | [
""
] | [
8778
] | 1 | [
"REACTOME"
] | [
"R-HSA-9031628"
] | [
"REACTOME:R-HSA-9031628"
] | 1 | [] | 0 | [
"PUB00000717",
"PUB00004974",
"PUB00085017",
"PUB00085019"
] | [
"1755826",
"7553065",
"25751153",
"26700681"
] | [
"The helix-loop-helix domain: a common motif for bristles, muscles and sex.",
"Transcription factors 2: helix-loop-helix.",
"MASH1/Ascl1a leads to GAP43 expression and axon regeneration in the adult CNS.",
"A novel role for Ascl1 in the regulation of mesendoderm formation via HDAC-dependent antagonism of VegT... | [
1991,
1995,
2015,
2016
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8778
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
69,
2,
2,
3,
2,
5,
1,
13,
5,
16
] | 10 | true | Family | Achaete-scute transcription factor-related | Achaete-scute transcription factor-related | MASH1/Ascl1a-like | 6 |
IPR015661 | 15,661 | Mitotic spindle checkpoint protein Bub1/Mad3 | Bub1/Mad3 | Family | 7,703 | false | false | This represents the mitotic checkpoint serine/threonine-protein kinase Bub1. | [
"GO:0007094"
] | [
"mitotic spindle assembly checkpoint signaling"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR14030"
] | [
""
] | [
7703
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11.1",
"R-CEL-141430",
"R-DDI-141430",
"R-DDI-174184",
"R-DDI-176409",
"R-DDI-179409",
"R-HSA-141430",
"R-HSA-141444",
"R-HSA-174184",
"R-HSA-176409",
"R-HSA-179409",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9648025",
"R-MMU-141430",
"R-MMU-1414... | [
"EC:2.7.11.1",
"REACTOME:R-CEL-141430",
"REACTOME:R-DDI-141430",
"REACTOME:R-DDI-174184",
"REACTOME:R-DDI-176409",
"REACTOME:R-DDI-179409",
"REACTOME:R-HSA-141430",
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-174184",
"REACTOME:R-HSA-176409",
"REACTOME:R-HSA-179409",
"REACTOME:R-HSA-2467813",
"... | 28 | [
"2lah",
"2wvi",
"3esl",
"3si5",
"4a1g",
"4aez",
"4qpm",
"4r8q",
"5dmz",
"5khu",
"5lcw",
"6f7b",
"6jkk",
"6jkm",
"6tlj"
] | 15 | [
"PUB00017177",
"PUB00063118",
"PUB00074625",
"PUB00074626",
"PUB00074627",
"PUB00074628"
] | [
"10704439",
"12769845",
"10395177",
"9521327",
"17369399",
"19503101"
] | [
"MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p.",
"Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint.",
"Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines.",
"Mutations of mitotic c... | [
2000,
2003,
1999,
1998,
2007,
2009
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
6,
7697
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
2,
19,
4,
10,
10,
2,
13,
6,
2,
2,
20
] | 12 | true | Family | Mitotic spindle checkpoint protein Bub1/Mad3 | Mitotic spindle checkpoint protein Bub1/Mad3 | Bub1/Mad3 | 6 |
IPR015662 | 15,662 | Promotilin | Promotilin | Family | 565 | false | false | Promotilin can be cleaved into two chains: motilin and motilin-associated peptide. Motilin plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle [ ]. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14156"
] | [
""
] | [
565
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-375276",
"R-HSA-416476"
] | [
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476"
] | 2 | [] | 0 | [
"PUB00074886"
] | [
"4941085"
] | [
"The further purification of motilin, a gastric motor activity stimulating polypeptide from the mucosa of the small intestine of hogs."
] | [
1971
] | 1 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
565
] | 1 | [
"Homo sapiens"
] | [
1
] | 1 | true | Family | Promotilin | Promotilin | Promotilin | 3 |
IPR015664 | 15,664 | P53-induced protein | P53_induced | Family | 3,173 | false | false | This entry includes p53-induced proteins that are members of the Pmp22 family of tetraspan membrane proteins. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14399"
] | [
""
] | [
3173
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6803205",
"R-HSA-6809371",
"R-MMU-6809371"
] | [
"REACTOME:R-HSA-6803205",
"REACTOME:R-HSA-6809371",
"REACTOME:R-MMU-6809371"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Ciceribacter ferrooxidans",
"Eumetazoa"
] | [
1,
3172
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2,
2,
2,
5
] | 6 | true | Family | P53-induced protein | P53-induced protein | P53_induced | 7 |
IPR015666 | 15,666 | Sarcoplasmic reticulum histidine-rich calcium-binding protein | HRC | Family | 558 | false | false | The histidine-rich calcium-binding protein of sarcoplasmic reticulum (HRC) may play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle [ ]. This protein is very acidic (31% of Asp and Glu) and rich in histidine (13%). The sequence of HRC contains 10 tandem repeats of a... | [
"GO:0005509"
] | [
"calcium ion binding"
] | [
"molecular_function"
] | 1 | [
"PANTHER"
] | [
"PTHR15054"
] | [
""
] | [
558
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-381426",
"R-HSA-8957275"
] | [
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8957275"
] | 2 | [] | 0 | [
"PUB00002520"
] | [
"2808365"
] | [
"Molecular cloning of a histidine-rich Ca2+-binding protein of sarcoplasmic reticulum that contains highly conserved repeated elements."
] | [
1989
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
558
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
7,
5,
7
] | 4 | true | Family | Sarcoplasmic reticulum histidine-rich calcium-binding protein | Sarcoplasmic reticulum histidine-rich calcium-binding protein | HRC | 8 |
IPR015667 | 15,667 | Telethonin | Telethonin | Family | 870 | false | false | Telethonin is found at the Z-disc of sarcomeres. It is the phosphorylation target of the kinase domain of titin, and is thought to play a role in muscle development [ , ]. Deletion of the C terminus of titin, including the kinase domain, has been found to impair myofibrillogenesis [ ]. Mutations of telethonin cause lim... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF09470",
"PTHR15143"
] | [
"Telethonin",
""
] | [
870,
853
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-390522",
"R-HSA-390522",
"R-MMU-390522"
] | [
"REACTOME:R-BTA-390522",
"REACTOME:R-HSA-390522",
"REACTOME:R-MMU-390522"
] | 3 | [
"1ya5",
"2f8v"
] | 2 | [
"PUB00034631",
"PUB00035182",
"PUB00035183",
"PUB00035184",
"PUB00040581"
] | [
"9804419",
"10481174",
"14600266",
"12379311",
"16713295"
] | [
"Structural basis for activation of the titin kinase domain during myofibrillogenesis.",
"Titin: a molecular control freak.",
"A targeted deletion of the C-terminal end of titin, including the titin kinase domain, impairs myofibrillogenesis.",
"Telethonin protein expression in neuromuscular disorders.",
"Ev... | [
1998,
1999,
2003,
2002,
2006
] | 5 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
870
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
25,
4,
3,
3
] | 4 | true | Family | Telethonin | Telethonin | Telethonin | 3 |
IPR015668 | 15,668 | B Cell Lymphoma 9 | Bcl-9/Bcl-9l | Family | 2,254 | false | false | BCL9 is associated with B-cell acute lymphoblastic leukemia [ ]. This entry includes BCL9 and BCL9L. They are tissue-specific transcriptional cofactors that cooperate with beta-catenin. In the nucleus, Bcl9 and Bcl9l simultaneously bind beta-catenin and the transcriptional activator Pygo2 to promote the transcription o... | [
"GO:0003713",
"GO:0008013",
"GO:0060070"
] | [
"transcription coactivator activity",
"beta-catenin binding",
"canonical Wnt signaling pathway"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PANTHER"
] | [
"PTHR15185"
] | [
""
] | [
2254
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-201722",
"R-HSA-201722",
"R-HSA-3769402",
"R-MMU-201722"
] | [
"REACTOME:R-DRE-201722",
"REACTOME:R-HSA-201722",
"REACTOME:R-HSA-3769402",
"REACTOME:R-MMU-201722"
] | 4 | [
"2gl7",
"2vp7",
"2vpb",
"2vpd",
"2vpe",
"2vpg",
"3sl9"
] | 7 | [
"PUB00035231",
"PUB00084974"
] | [
"9490669",
"28174279"
] | [
"Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21.",
"A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation."
] | [
1998,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2254
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
7,
4,
7
] | 4 | true | Family | B Cell Lymphoma 9 | B Cell Lymphoma 9 | Bcl-9/Bcl-9l | 3 |
IPR015669 | 15,669 | Endothelial protein C receptor | Endothetial_C_recpt | Family | 652 | false | false | Upon vascular injury, flowing blood is exposed to cells expressing tissue factor (TF) on their surfaces and FVII/FVIIa binds to its receptor/cofactor TF and is rapidly activated to FVIIa and the activity of bound FVIIa is dramatically enhanced. The TF/FVIIa complex activates zymogens factor X (FX) and factor IX (FIX). ... | [
"GO:0038023"
] | [
"signaling receptor activity"
] | [
"molecular_function"
] | 1 | [
"PANTHER"
] | [
"PTHR15349"
] | [
""
] | [
652
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-140875",
"R-BTA-202733",
"R-HSA-140875",
"R-HSA-202733",
"R-MMU-140875",
"R-MMU-202733",
"R-RNO-140875",
"R-RNO-202733"
] | [
"REACTOME:R-BTA-140875",
"REACTOME:R-BTA-202733",
"REACTOME:R-HSA-140875",
"REACTOME:R-HSA-202733",
"REACTOME:R-MMU-140875",
"REACTOME:R-MMU-202733",
"REACTOME:R-RNO-140875",
"REACTOME:R-RNO-202733"
] | 8 | [
"1l8j",
"1lqv",
"3jtc",
"4v3d",
"4v3e",
"6sny",
"7oks",
"7okt",
"7oku",
"7okv",
"7q5d",
"8c44"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Amniota"
] | [
652
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
4
] | 3 | true | Family | Endothelial protein C receptor | Endothelial protein C receptor | Endothetial_C_recpt | 4 |
IPR015671 | 15,671 | GLTSCR protein, conserved domain | GSCR1_dom | Domain | 3,867 | false | false | This domain is found in glioma tumour suppressor candidate region gene 1 (GLTSCR1, also known as BICRAL) protein, and is typically between 105 and 124 amino acids in length. GLTSCR1 is a component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF15249"
] | [
"GLTSCR1"
] | [
3867
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9933947",
"R-MMU-9933947"
] | [
"REACTOME:R-HSA-9933947",
"REACTOME:R-MMU-9933947"
] | 2 | [] | 0 | [
"PUB00034953",
"PUB00045218",
"PUB00088478"
] | [
"15834925",
"17474147",
"29374058"
] | [
"Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas.",
"Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.",
"Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form ... | [
2005,
2007,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3867
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
7,
1,
14,
4,
4,
4,
12,
9,
8
] | 9 | true | Domain | GLTSCR protein, conserved domain | GLTSCR protein, conserved domain | GSCR1_dom | 7 |
IPR015672 | 15,672 | The Golgi pH regulator/GPCR-type G protein | GPHR/GTG | Family | 4,820 | false | false | This entry include human Golgi pH regulators (GPHR) and GPCR-type G proteins (GTG1 and GTG2) from Arabidopsis. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15948"
] | [
""
] | [
4820
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00059166",
"PUB00059167"
] | [
"19135895",
"18794847"
] | [
"Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis.",
"GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus."
] | [
2009,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4820
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
16,
4,
2,
1,
13,
2,
1,
1,
7,
1,
18
] | 11 | true | Family | The Golgi pH regulator/GPCR-type G protein | The Golgi pH regulator/GPCR-type G protein | GPHR/GTG | 6 |
IPR015673 | 15,673 | Enamelin | Enamelin | Family | 556 | false | false | Enamelin is a secreted structural protein that acts to create dental enamel matrix. Enamelin protein is proteolytically cleaved into several products, which are identified by their molecular weights and appear to have different functions in different enamel compartments. It is not currently known how enamelin interacts... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF15362",
"PTHR16784"
] | [
"Enamelin",
""
] | [
538,
556
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-381426",
"R-HSA-8957275",
"R-MMU-381426",
"R-MMU-8957275"
] | [
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8957275",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-8957275"
] | 4 | [] | 0 | [
"PUB00035154",
"PUB00035155"
] | [
"14656895",
"11037750"
] | [
"Enamelin and autosomal-dominant amelogenesis imperfecta.",
"Enamelin maps to human chromosome 4q21 within the autosomal dominant amelogenesis imperfecta locus."
] | [
2003,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
556
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
4
] | 3 | true | Family | Enamelin | Enamelin | Enamelin | 4 |
IPR015675 | 15,675 | Secretin precursor | Prosecretin | Family | 530 | false | false | A number of polypeptidic hormones, mainly expressed in the intestine or the pancreas, belong to a group of structurally related peptides [ , ]. Members of the structurally similar group include glucagon, glicentin precursor, secretin, gastric inhibitory protein, vasoactive intestinal peptide (VIP), prealbumin, peptide ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR17378"
] | [
""
] | [
530
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-418555",
"R-HSA-420092",
"R-MMU-418555",
"R-MMU-420092",
"R-RNO-420092",
"R-SSC-418555",
"R-SSC-420092"
] | [
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-420092",
"REACTOME:R-MMU-418555",
"REACTOME:R-MMU-420092",
"REACTOME:R-RNO-420092",
"REACTOME:R-SSC-418555",
"REACTOME:R-SSC-420092"
] | 7 | [
"6wi9",
"6wzg",
"7d3s"
] | 3 | [
"PUB00000024",
"PUB00000025",
"PUB00035042",
"PUB00035043",
"PUB00035044",
"PUB00070144",
"PUB00095381",
"PUB00095382"
] | [
"3133967",
"3291691",
"2315322",
"11060443",
"7612008",
"2395872",
"25332973",
"30449620"
] | [
"Vasoactive intestinal polypeptide and related peptides. Isolation and chemistry.",
"Glucagon and related peptides. Molecular structure and biological specificity.",
"Secretin: structure of the precursor and tissue distribution of the mRNA.",
"Human secretin (SCT): gene structure, chromosome location, and dis... | [
1988,
1988,
1990,
2000,
1995,
1990,
2013,
2018
] | 8 | [] | [] | 0 | 0 | null | [
"Amniota"
] | [
530
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
2
] | 3 | true | Family | Secretin precursor | Secretin precursor | Prosecretin | 8 |
IPR015676 | 15,676 | Tob1/2 | Tob1/2 | Family | 2,472 | false | false | Tob1 and Tob2 are members of the BTG/Tob family. The BTG/Tob family members contain an conserved N-terminal domain, known as APRO domain (AntiPROliferative) or BTG domain. In mammals, six family members have been identified: BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. They interact with CAF1, a subuni... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR17537"
] | [
""
] | [
2472
] | 1 | [] | [] | [] | 0 | [
"2d5r",
"2z15",
"5ci8",
"5ci9",
"5td6"
] | 5 | [
"PUB00078467"
] | [
"19746446"
] | [
"The mammalian anti-proliferative BTG/Tob protein family."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2472
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
4,
5,
7,
7
] | 6 | true | Family | Tob1/2 | Tob1/2 | Tob1/2 | 4 |
IPR015679 | 15,679 | Phospholipase D family | PLipase_D_fam | Family | 24,004 | false | false | Phospholipase D (PLD) catalyses the hydrolysis of the phosphodiester bond of glycerophospholipids to generate phosphatidic acid and a free head group. Phospholipase D activities have been detected in simple to complex organisms from viruses and bacteria to yeast, plants, and mammals [ ]. In higher organisms, PLD specif... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR18896"
] | [
""
] | [
24004
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"R... | [
"3.1.4.4",
"PWY-3561",
"PWY-7039",
"R-DDI-1483166",
"R-DDI-2029485",
"R-DDI-6798695",
"R-DDI-9013149",
"R-DDI-9013404",
"R-DDI-9013408",
"R-HSA-1483148",
"R-HSA-1483166",
"R-HSA-2029485",
"R-HSA-6798695",
"R-HSA-8980692",
"R-HSA-9013148",
"R-HSA-9013149",
"R-HSA-9013404",
"R-HSA-90... | [
"EC:3.1.4.4",
"METACYC:PWY-3561",
"METACYC:PWY-7039",
"REACTOME:R-DDI-1483166",
"REACTOME:R-DDI-2029485",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-9013149",
"REACTOME:R-DDI-9013404",
"REACTOME:R-DDI-9013408",
"REACTOME:R-HSA-1483148",
"REACTOME:R-HSA-1483166",
"REACTOME:R-HSA-2029485",
"REA... | 40 | [
"6kz8",
"6kz9",
"6ohm",
"6oho",
"6ohp",
"6ohq",
"6ohr",
"6ohs",
"6u8z",
"7svp",
"7v53",
"7v55",
"7wdk"
] | 13 | [
"PUB00034910",
"PUB00034911",
"PUB00034912",
"PUB00053993"
] | [
"15052340",
"10818442",
"14517341",
"19439403"
] | [
"Phospholipase D.",
"Phospholipase D.",
"Phospholipase D in cell proliferation and cancer.",
"A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria."
] | [
2004,
2000,
2003,
2009
] | 4 | [] | [
"IPR011402",
"IPR016555"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
4067,
19902,
14,
21
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
67,
1,
21,
6,
9,
11,
3,
60,
13,
1,
1,
125
] | 12 | true | Family | Phospholipase D family | Phospholipase D family | PLipase_D_fam | 3 |
IPR015683 | 15,683 | Ionotropic glutamate receptor | Ionotropic_Glu_rcpt | Family | 61,666 | false | false | Ionotropic glutamate receptors (iGluRs) are a highly conserved family of ligand-gated ion channels present in animals, plants, and bacteria, which are best characterised for their roles in synaptic communication in vertebrate nervous systems [ ]. A variant subfamily of iGluRs, the Ionotropic Receptors (IRs), consist of... | [] | [] | [] | 0 | [
"PANTHER",
"PANTHER"
] | [
"PTHR18966",
"PTHR34836"
] | [
"",
""
] | [
55096,
6570
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-204005",
"R-CEL-399710",
"R-CEL-438066",
"R-CEL-5694530",
"R-CEL-8849932",
"R-CFA-3928662",
"R-CFA-438066",
"R-CFA-5673001",
"R-CFA-8849932",
"R-CFA-9609736",
"R-DME-204005",
"R-DME-3928662",
"R-DME-399710",
"R-DME-416993",
"R-DME-438066",
"R-DME-5694530",
"R-DME-8849932",
"... | [
"REACTOME:R-CEL-204005",
"REACTOME:R-CEL-399710",
"REACTOME:R-CEL-438066",
"REACTOME:R-CEL-5694530",
"REACTOME:R-CEL-8849932",
"REACTOME:R-CFA-3928662",
"REACTOME:R-CFA-438066",
"REACTOME:R-CFA-5673001",
"REACTOME:R-CFA-8849932",
"REACTOME:R-CFA-9609736",
"REACTOME:R-DME-204005",
"REACTOME:R-D... | 63 | [
"1ftj",
"1ftk",
"1ftl",
"1ftm",
"1fto",
"1fw0",
"1gr2",
"1lb8",
"1lb9",
"1lbb",
"1lbc",
"1m5b",
"1m5c",
"1m5d",
"1m5e",
"1m5f",
"1mm6",
"1mm7",
"1mqd",
"1mqg",
"1mqh",
"1mqi",
"1mqj",
"1ms7",
"1mxu",
"1mxv",
"1mxw",
"1mxx",
"1mxy",
"1mxz",
"1my0",
"1my1"... | 815 | [
"PUB00072709",
"PUB00072710"
] | [
"14977400",
"20808886"
] | [
"Structure and function of glutamate receptor ion channels.",
"Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction."
] | [
2004,
2010
] | 2 | [] | [
"IPR001508",
"IPR017103"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Paramecium bursaria Chlorella virus 1",
"metagenomes",
"unclassified Candidatus Methanogaster"
] | [
1174,
60470,
1,
19,
2
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
136,
17,
238,
47,
124,
82,
88,
106,
92
] | 9 | true | Family | Ionotropic glutamate receptor | Ionotropic glutamate receptor | Ionotropic_Glu_rcpt | 3 |
IPR015685 | 15,685 | Aquaporin 9 | Aquaporin_9 | Family | 630 | false | false | Aquaporins are water channels, present in both higher and lower organisms, that belong to the major intrinsic protein family. Most aquaporins are highly selective for water, though some also facilitate the movement of small uncharged molecules such as glycerol [ ]. In higher eukaryotes these proteins play diverse roles... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02021"
] | [
"AQUAPORIN9"
] | [
630
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-432030",
"R-HSA-432047",
"R-MMU-432030",
"R-MMU-432047",
"R-RNO-432030",
"R-RNO-432047"
] | [
"REACTOME:R-HSA-432030",
"REACTOME:R-HSA-432047",
"REACTOME:R-MMU-432030",
"REACTOME:R-MMU-432047",
"REACTOME:R-RNO-432030",
"REACTOME:R-RNO-432047"
] | 6 | [] | 0 | [
"PUB00028718",
"PUB00031522",
"PUB00033222",
"PUB00033223",
"PUB00033224",
"PUB00035072",
"PUB00035073",
"PUB00043535",
"PUB00083165",
"PUB00095345"
] | [
"11780053",
"15377788",
"15340377",
"16406529",
"14691544",
"9514918",
"12594337",
"16650285",
"10872456",
"30420639"
] | [
"Structural basis of water-specific transport through the AQP1 water channel.",
"The channel architecture of aquaporin 0 at a 2.2-A resolution.",
"From structure to disease: the evolving tale of aquaporin biology.",
"Why do microorganisms have aquaporins?",
"Architecture and selectivity in aquaporins: 2.5 a... | [
2001,
2004,
2004,
2006,
2003,
1998,
2003,
2006,
1999,
2018
] | 10 | [
"IPR000425"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
630
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
5,
4
] | 3 | true | Family | Aquaporin 9 | Aquaporin 9 | Aquaporin_9 | 9 |
IPR015688 | 15,688 | Elongation Factor 3, ABC2 domain, chromodomain-like insertion | eEF3_ABC2_chromodomain-like | Domain | 3,316 | false | false | This entry includes members of the EF3 (Elongation Factor 3) family, which contain the ABC transporter domains and belong to the family of ABC (ATP-binding cassette) proteins. Yef3 (elongation factor 3A) and Hef3 (elongation factor 3B) are included in this entry. The ribosomal elongation cycle requires two elongation f... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd18626"
] | [
"CD_eEF3"
] | [
3316
] | 1 | [
"EC",
"METACYC",
"REACTOME"
] | [
"3.6.4.-",
"PWY-7250",
"R-SCE-382556"
] | [
"EC:3.6.4.-",
"METACYC:PWY-7250",
"REACTOME:R-SCE-382556"
] | 3 | [
"2iw3",
"2iwh",
"2ix3",
"2ix8",
"6s47",
"7b7d",
"8yld",
"8ylr",
"8z71"
] | 9 | [
"PUB00041798",
"PUB00095258"
] | [
"16929303",
"22888004"
] | [
"Structure of eEF3 and the mechanism of transfer RNA release from the E-site.",
"Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation."
] | [
2006,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Chlorovirus",
"Eukaryota",
"viral metagenome"
] | [
8,
3305,
3
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
3,
1
] | 3 | true | Domain | Elongation Factor 3, ABC2 domain, chromodomain-like insertion | Elongation Factor 3, ABC2 domain, chromodomain-like insertion | eEF3_ABC2_chromodomain-like | 6 |
IPR015700 | 15,700 | DNA-directed RNA polymerase III subunit RPC1 | RPC1 | Family | 6,226 | false | false | This entry represents the DNA-directed RNA polymerase III subunit RPC1. DNA-directed RNA polymerases (also known as DNA-dependent RNA polymerases) are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. In eukaryotes, there are three different forms of DNA-directed R... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48446"
] | [
""
] | [
6226
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7.6",
"R-BTA-76061",
"R-BTA-76066",
"R-BTA-76071",
"R-DDI-76061",
"R-DDI-76066",
"R-HSA-1834949",
"R-HSA-73780",
"R-HSA-73980",
"R-HSA-749476",
"R-HSA-76061",
"R-HSA-76066",
"R-HSA-76071",
"R-SCE-76066",
"R-SPO-76061",
"R-SPO-76066"
] | [
"EC:2.7.7.6",
"REACTOME:R-BTA-76061",
"REACTOME:R-BTA-76066",
"REACTOME:R-BTA-76071",
"REACTOME:R-DDI-76061",
"REACTOME:R-DDI-76066",
"REACTOME:R-HSA-1834949",
"REACTOME:R-HSA-73780",
"REACTOME:R-HSA-73980",
"REACTOME:R-HSA-749476",
"REACTOME:R-HSA-76061",
"REACTOME:R-HSA-76066",
"REACTOME:R... | 16 | [
"5fj8",
"5fj9",
"5fja",
"6cnb",
"6cnc",
"6cnd",
"6cnf",
"6eu0",
"6eu1",
"6eu2",
"6eu3",
"6f40",
"6f41",
"6f42",
"6f44",
"6tut",
"7a6h",
"7ae1",
"7ae3",
"7aea",
"7ast",
"7d58",
"7d59",
"7dn3",
"7du2",
"7fji",
"7fjj",
"7z0h",
"7z1l",
"7z1m",
"7z1n",
"7z1o"... | 54 | [
"PUB00000061",
"PUB00033173"
] | [
"3052291",
"10499798"
] | [
"Structure and function of bacterial sigma factors.",
"Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution."
] | [
1988,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Eukaryota",
"ecological metagenomes"
] | [
4,
6219,
3
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
2,
4,
10,
2,
1,
3,
4,
1,
1,
18
] | 12 | true | Family | DNA-directed RNA polymerase III subunit RPC1 | DNA-directed RNA polymerase III subunit RPC1 | RPC1 | 4 |
IPR015701 | 15,701 | Ferredoxin--NADP reductase | FNR | Family | 3,999 | false | false | null | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF000361",
"PTHR43314"
] | [
"Frd-NADP+_RD",
""
] | [
3249,
3988
] | 2 | [
"EC",
"METACYC",
"METACYC"
] | [
"1.18.1.2",
"PWY-101",
"PWY-8271"
] | [
"EC:1.18.1.2",
"METACYC:PWY-101",
"METACYC:PWY-8271"
] | 3 | [
"1b2r",
"1bjk",
"1bqe",
"1bx0",
"1bx1",
"1e62",
"1e63",
"1e64",
"1ewy",
"1fnb",
"1fnc",
"1fnd",
"1frn",
"1frq",
"1gaq",
"1gaw",
"1gjr",
"1go2",
"1gr1",
"1h42",
"1h85",
"1jb9",
"1ogi",
"1ogj",
"1qfy",
"1qfz",
"1qg0",
"1qga",
"1qgy",
"1qgz",
"1qh0",
"1que"... | 83 | [
"PUB00001372",
"PUB00001683",
"PUB00002328",
"PUB00002509",
"PUB00002674",
"PUB00003255",
"PUB00004098",
"PUB00005007",
"PUB00005135",
"PUB00005247",
"PUB00005356",
"PUB00005367",
"PUB00043075"
] | [
"2924777",
"7890048",
"3700359",
"2550423",
"1748631",
"2319593",
"1712077",
"8298460",
"1986412",
"7812715",
"2204158",
"1908607",
"15458418"
] | [
"cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases.",
"Specific arrangement of three amino acid residues for flavin-binding barrel structures in NADH-cytochrome b5 reductase and the other flavin-dependent reductases.",
"Complete amino acid sequence of NADH-cytochrom... | [
1989,
1995,
1986,
1989,
1991,
1990,
1991,
1993,
1991,
1994,
1990,
1991,
2004
] | 13 | [] | [
"IPR017634",
"IPR035442"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Halorussus caseinilyticus",
"unclassified sequences"
] | [
1343,
2646,
1,
9
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
20,
8,
34
] | 3 | true | Family | Ferredoxin--NADP reductase | Ferredoxin--NADP reductase | FNR | 4 |
IPR015707 | 15,707 | Beta-2-Microglobulin | B2Microglobulin | Family | 394 | false | false | Beta-2-microglobulin (Beta2m) constitutes the 12kDa light chain of the class I major histocompatibility complex (MHC-I) on the surface of many cells, to which it is non-covalently associated. It is also found in the serum in a free form. Beta-2-microglobulin co-association with the MHC class I heavy chain is prerequisi... | [
"GO:0006955",
"GO:0042612"
] | [
"immune response",
"MHC class I protein complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"CDD"
] | [
"cd05770"
] | [
"IgC1_beta2m"
] | [
394
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1236974",
"R-BTA-1236977",
"R-BTA-198933",
"R-BTA-2424491",
"R-BTA-6798695",
"R-BTA-983170",
"R-DRE-1236974",
"R-DRE-1236977",
"R-DRE-2132295",
"R-DRE-6798695",
"R-DRE-983170",
"R-GGA-1236974",
"R-GGA-1236977",
"R-GGA-198933",
"R-GGA-2424491",
"R-GGA-6798695",
"R-GGA-983170",
... | [
"REACTOME:R-BTA-1236974",
"REACTOME:R-BTA-1236977",
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-2424491",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-983170",
"REACTOME:R-DRE-1236974",
"REACTOME:R-DRE-1236977",
"REACTOME:R-DRE-2132295",
"REACTOME:R-DRE-6798695",
"REACTOME:R-DRE-983170",
"REACTOME:R... | 50 | [
"1a1m",
"1a1n",
"1a1o",
"1a6z",
"1a9b",
"1a9e",
"1agb",
"1agc",
"1agd",
"1age",
"1agf",
"1akj",
"1ao7",
"1b0g",
"1b0r",
"1bd2",
"1bii",
"1bmg",
"1bqh",
"1bz9",
"1c16",
"1cd1",
"1ce6",
"1cg9",
"1ddh",
"1de4",
"1duy",
"1duz",
"1e27",
"1e28",
"1ed3",
"1eey"... | 1,737 | [
"PUB00029693"
] | [
"14595439"
] | [
"Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b)."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
394
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
3,
3
] | 4 | true | Family | Beta-2-Microglobulin | Beta-2-Microglobulin | B2Microglobulin | 6 |
IPR015712 | 15,712 | DNA-directed RNA polymerase, subunit 2 | DNA-dir_RNA_pol_su2 | Family | 125,802 | false | false | This entry represents the beta subunit (also referred to as subunit 2) from DNA-dependent RNA polymerases. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). Each RNA pol... | [
"GO:0003899",
"GO:0032549",
"GO:0006351"
] | [
"DNA-directed RNA polymerase activity",
"ribonucleoside binding",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PANTHER",
"CDD"
] | [
"PTHR20856",
"cd00653"
] | [
"",
"RNA_pol_B_RPB2"
] | [
125444,
61643
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.7.6",
"R-BTA-112382",
"R-BTA-113418",
"R-BTA-5578749",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-6803529",
"R-BTA-6807505",
"R-BTA-72086",
"R-BTA-72163",
"R-BTA-72165",
"R-BTA-72203",
"R-BTA-73776",
"R-BTA-73779",
"R-BTA-75953",... | [
"EC:2.7.7.6",
"REACTOME:R-BTA-112382",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-5578749",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-6803529",
"REACTOME:R-BTA-6807505",
"REACTOME:R-BTA-72086",... | 214 | [
"1hqm",
"1i3q",
"1i50",
"1i6h",
"1i6v",
"1iw7",
"1k83",
"1l9u",
"1l9z",
"1nik",
"1nt9",
"1pqv",
"1r5u",
"1r9s",
"1r9t",
"1sfo",
"1smy",
"1twa",
"1twc",
"1twf",
"1twg",
"1twh",
"1wcm",
"1y1v",
"1y1w",
"1y1y",
"1y77",
"1ynj",
"1ynn",
"1zyr",
"2a68",
"2a69"... | 1,220 | [
"PUB00000061",
"PUB00010734",
"PUB00011749",
"PUB00013986",
"PUB00022053",
"PUB00025919",
"PUB00028105",
"PUB00033173",
"PUB00079994",
"PUB00079995",
"PUB00080226"
] | [
"3052291",
"11909517",
"12000971",
"12191485",
"12016307",
"11313499",
"10684922",
"10499798",
"11839495",
"11297923",
"10066472"
] | [
"Structure and function of bacterial sigma factors.",
"The RNA polymerase II machinery: structure illuminates function.",
"Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution.",
"Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction.",... | [
1988,
2002,
2002,
2002,
2002,
2001,
2000,
1999,
2002,
2001,
1998
] | 11 | [] | [
"IPR010243"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1881,
41392,
80650,
535,
1344
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
32,
3,
4,
4,
1,
21,
9,
3,
30,
9,
3,
3,
107
] | 13 | true | Family | DNA-directed RNA polymerase, subunit 2 | DNA-directed RNA polymerase, subunit 2 | DNA-dir_RNA_pol_su2 | 2 |
IPR015720 | 15,720 | Transmembrane emp24 domain-containing protein | Emp24-like | Family | 27,582 | false | false | This group of proteins consists of TMP21 (also known as transmembrane emp24 domain-containing protein 10) and related proteins, which are members of the p24 family. The p24 family is a widely conserved family of transmembrane proteins that plays a functional role in the initiation of assembly of COPI (Coat protein I) c... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22811"
] | [
""
] | [
27582
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-204005",
"R-BTA-3238698",
"R-BTA-5694530",
"R-BTA-6807878",
"R-BTA-6811434",
"R-CEL-1912420",
"R-CEL-6807878",
"R-CEL-6811434",
"R-DDI-6807878",
"R-DDI-6811434",
"R-DME-6807878",
"R-DME-6811434",
"R-HSA-1912420",
"R-HSA-204005",
"R-HSA-3238698",
"R-HSA-5694530",
"R-HSA-6807878... | [
"REACTOME:R-BTA-204005",
"REACTOME:R-BTA-3238698",
"REACTOME:R-BTA-5694530",
"REACTOME:R-BTA-6807878",
"REACTOME:R-BTA-6811434",
"REACTOME:R-CEL-1912420",
"REACTOME:R-CEL-6807878",
"REACTOME:R-CEL-6811434",
"REACTOME:R-DDI-6807878",
"REACTOME:R-DDI-6811434",
"REACTOME:R-DME-6807878",
"REACTOME... | 34 | [
"5azw",
"5azx",
"5azy",
"5gu5",
"7rrm",
"9cjk",
"9cjl"
] | 7 | [
"PUB00003083",
"PUB00009426",
"PUB00009427",
"PUB00034783",
"PUB00034784"
] | [
"9472029",
"8947548",
"8663407",
"15145531",
"9681629"
] | [
"gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer.",
"A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding.",
"Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein fami... | [
1998,
1996,
1996,
2004,
1998
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Vibrio"
] | [
27569,
13
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
40,
6,
19,
12,
38,
41,
4,
29,
39,
8,
4,
40
] | 12 | true | Family | Transmembrane emp24 domain-containing protein | Transmembrane emp24 domain-containing protein | Emp24-like | 5 |
IPR015725 | 15,725 | Myosin Light Chain Kinase 1, Kinase domain | MLCK1_kinase_dom | Domain | 681 | false | false | Smooth muscle myosin light chain kinase (also known as MLCK1) is a Ser/Thr protein kinase that phosphorylates phosphorylates the 20kDa myosin regulatory light chain (RLC) of smooth and nonmuscle myosin II in the presence of Ca2+ and calmodulin, which facilitates myosin interaction with actin filaments [ , ]. In mice, t... | [
"GO:0004672",
"GO:0006468"
] | [
"protein kinase activity",
"protein phosphorylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"CDD"
] | [
"cd14191"
] | [
"STKc_MLCK1"
] | [
681
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.18",
"R-BTA-445355",
"R-BTA-5627123",
"R-HSA-445355",
"R-HSA-5627123",
"R-MMU-445355",
"R-MMU-5627123"
] | [
"EC:2.7.11.18",
"REACTOME:R-BTA-445355",
"REACTOME:R-BTA-5627123",
"REACTOME:R-HSA-445355",
"REACTOME:R-HSA-5627123",
"REACTOME:R-MMU-445355",
"REACTOME:R-MMU-5627123"
] | 7 | [] | 0 | [
"PUB00083900",
"PUB00083901"
] | [
"18053800",
"16774989"
] | [
"Role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, a review dedicated to Dr. Setsuro Ebashi.",
"Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues."
] | [
2008,
2006
] | 2 | [
"IPR000719"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
681
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
4,
2,
4
] | 4 | true | Domain | Myosin Light Chain Kinase 1, Kinase domain | Myosin Light Chain Kinase 1, Kinase domain | MLCK1_kinase_dom | 4 |
IPR015753 | 15,753 | Leucine-rich repeat-containing protein 37 | LRRC37 | Family | 1,445 | false | false | This entry represents the leucine-rich repeat-containing protein 37. They are single-pass type I membrane proteins with unknown function. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23045"
] | [
""
] | [
1445
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1445
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
43,
4,
8
] | 3 | true | Family | Leucine-rich repeat-containing protein 37 | Leucine-rich repeat-containing protein 37 | LRRC37 | 8 |
IPR015758 | 15,758 | Ral guanine nucleotide dissociation stimulator, RA domain | RalGDS_RA | Domain | 1,722 | false | false | RalGDS family members can act both as Ras effectors and as guanine nucleotide exchange factors (GEFs) for Ral. They act downstream of Ras and bind to the GTP-bound active form of Ras or Ras family members. They also promote the GDP to GTP exchange for Ral small GTPase, member of the Ras family [ ]. Due to their double ... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd17209"
] | [
"RA_RalGDS"
] | [
1722
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-171007",
"R-HSA-5673001",
"R-MMU-171007",
"R-MMU-5673001",
"R-RNO-171007",
"R-RNO-5673001"
] | [
"REACTOME:R-HSA-171007",
"REACTOME:R-HSA-5673001",
"REACTOME:R-MMU-171007",
"REACTOME:R-MMU-5673001",
"REACTOME:R-RNO-171007",
"REACTOME:R-RNO-5673001"
] | 6 | [
"1lfd",
"1lxd",
"1rax",
"2b3a",
"2rgf",
"3kh0"
] | 6 | [
"PUB00073922",
"PUB00073925",
"PUB00073929",
"PUB00074235",
"PUB00101735"
] | [
"10760592",
"20478380",
"15766660",
"9099691",
"26469971"
] | [
"The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization.",
"RalGDS family members couple Ras to Ral signalling and that's not all.",
"RalGDS is required for tumor formation in a model of skin carcinogenesis.",
"Characterization of Ral GDP dissociation stimulator-like (RGL) act... | [
2000,
2010,
2005,
1997,
2015
] | 5 | [
"IPR000159"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1722
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
6,
8,
7
] | 4 | true | Domain | Ral guanine nucleotide dissociation stimulator, RA domain | Ral guanine nucleotide dissociation stimulator, RA domain | RalGDS_RA | 3 |
IPR015771 | 15,771 | Anti-muellerian hormone receptor, type II | Anti-muellerian_hrmn_rcpt_II | Family | 282 | false | false | Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substra... | [
"GO:0004675",
"GO:0005524",
"GO:0006468",
"GO:0016020"
] | [
"transmembrane receptor protein serine/threonine kinase activity",
"ATP binding",
"protein phosphorylation",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PIRSF"
] | [
"PIRSF037392"
] | [
"AMHRII"
] | [
282
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.30",
"R-HSA-201451",
"R-MMU-201451",
"R-RNO-201451"
] | [
"EC:2.7.11.30",
"REACTOME:R-HSA-201451",
"REACTOME:R-MMU-201451",
"REACTOME:R-RNO-201451"
] | 4 | [] | 0 | [
"PUB00005115",
"PUB00015362",
"PUB00020114",
"PUB00034898",
"PUB00034899",
"PUB00034960"
] | [
"3291115",
"12368087",
"12471243",
"15078142",
"15320712",
"14656470"
] | [
"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.",
"Evolution of protein kinase signaling from yeast to man.",
"The protein kinase complement of the human genome.",
"High-throughput structural biology in drug discovery: protein kinases.",
"Creating chemical dive... | [
1988,
2002,
2002,
2004,
2004,
2003
] | 6 | [
"IPR000333"
] | [] | 1 | 0 | 1 | [
"Theria"
] | [
282
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
6
] | 3 | true | Family | Anti-muellerian hormone receptor, type II | Anti-muellerian hormone receptor, type II | Anti-muellerian_hrmn_rcpt_II | 4 |
IPR015789 | 15,789 | Twist-related, basic helix-loop-helix domain | Twist-rel_bHLH | Domain | 211 | false | false | The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two α-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes be... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd11464"
] | [
"bHLH_TS_TWIST"
] | [
211
] | 1 | [
"REACTOME"
] | [
"R-DME-9764725"
] | [
"REACTOME:R-DME-9764725"
] | 1 | [] | 0 | [
"PUB00035177",
"PUB00076628",
"PUB00086584",
"PUB00086585"
] | [
"15294153",
"12806077",
"3416836",
"9716413"
] | [
"Epithelial-mesenchymal transitions: twist in development and metastasis.",
"The evolution of the neural basic Helix-Loop-Helix proteins.",
"Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos.",
"Analysis of a Caenorhabditis elegans Twist hom... | [
2004,
2001,
1988,
1998
] | 4 | [
"IPR011598"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
211
] | 1 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
1,
2
] | 2 | true | Domain | Twist-related, basic helix-loop-helix domain | Twist-related, basic helix-loop-helix domain | Twist-rel_bHLH | 3 |
IPR015791 | 15,791 | Antimicrobial/protein inhibitor, gamma-crystallin-like | Antimic/Inh_G_crystallin-like | Homologous_superfamily | 927 | false | false | This structural domain is found in a family of proteins with a Greek key motif [ ] that are related in structure to the beta/gamma crystallins. This group of proteins includes: Streptomyces killer toxin-like protein SKLP Antifungal protein, AFP1 Plant antimicrobial protein, MIAMP1 Streptomyces metalloproteinase inhibit... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:2.60.20.30"
] | [
""
] | [
927
] | 1 | [] | [] | [] | 0 | [
"1bhu",
"1c01",
"1f53",
"1g6e",
"1gh5"
] | 5 | [
"PUB00014133",
"PUB00014340",
"PUB00014341"
] | [
"14705960",
"8506258",
"9735297"
] | [
"Evolutionary families of peptidase inhibitors.",
"The Greek key motif: extraction, classification and analysis.",
"NMR structure of the Streptomyces metalloproteinase inhibitor, SMPI, isolated from Streptomyces nigrescens TK-23: another example of an ancestral beta gamma-crystallin precursor structure."
] | [
2004,
1993,
1998
] | 3 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota"
] | [
513,
414
] | 2 | [
"Zea mays"
] | [
4
] | 1 | true | Homologous_superfamily | Antimicrobial/protein inhibitor, gamma-crystallin-like | Antimicrobial/protein inhibitor, gamma-crystallin-like | Antimic/Inh_G_crystallin-like | 8 |
IPR015793 | 15,793 | Pyruvate kinase, barrel | Pyrv_Knase_brl | Domain | 50,689 | false | false | Pyruvate kinase ( ) (PK) catalyses the final step in glycolysis [ , ], the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP: ADP + phosphoenolpyruvate = ATP + pyruvate The enzyme, which is found in all living organisms, requires both magnesium and potassium ions for its activ... | [
"GO:0000287",
"GO:0004743",
"GO:0030955",
"GO:0006096"
] | [
"magnesium ion binding",
"pyruvate kinase activity",
"potassium ion binding",
"glycolytic process"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 4 | [
"PFAM"
] | [
"PF00224"
] | [
"PK"
] | [
50689
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME... | [
"2.7.1.40",
"PWY-1042",
"PWY-2221",
"PWY-5484",
"PWY-5723",
"PWY-6886",
"PWY-6901",
"PWY-7003",
"PWY-7218",
"PWY-7383",
"PWY-8004",
"PWY-8404",
"PDOC00101",
"R-CFA-70171",
"R-CFA-70268",
"R-DDI-6798695",
"R-DDI-70171",
"R-DDI-70268",
"R-DDI-9861718",
"R-DME-6798695",
"R-DME-7... | [
"EC:2.7.1.40",
"METACYC:PWY-1042",
"METACYC:PWY-2221",
"METACYC:PWY-5484",
"METACYC:PWY-5723",
"METACYC:PWY-6886",
"METACYC:PWY-6901",
"METACYC:PWY-7003",
"METACYC:PWY-7218",
"METACYC:PWY-7383",
"METACYC:PWY-8004",
"METACYC:PWY-8404",
"PROSITEDOC:PDOC00101",
"REACTOME:R-CFA-70171",
"REAC... | 50 | [
"1a3w",
"1a3x",
"1a49",
"1a5u",
"1aqf",
"1e0t",
"1e0u",
"1f3w",
"1f3x",
"1pkl",
"1pkm",
"1pkn",
"1pky",
"1t5a",
"1zjh",
"2e28",
"2g50",
"2vgb",
"2vgf",
"2vgg",
"2vgi",
"3bjf",
"3bjt",
"3e0v",
"3e0w",
"3eoe",
"3g2g",
"3gg8",
"3gqy",
"3gr4",
"3h6o",
"3hqn"... | 211 | [
"PUB00000569",
"PUB00014134",
"PUB00014243",
"PUB00024392",
"PUB00100069"
] | [
"2379684",
"11960989",
"12798932",
"10751408",
"29748232"
] | [
"Isoenzymes of pyruvate kinase.",
"Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia.",
"Pyruvate kinase: current status of regulatory and functional properties.",
"The allosteric regulation of pyruvate kinase.",
"An allostatic mechanism for M2 p... | [
1990,
2002,
2003,
2000,
2018
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctNmW2",
"unclassified sequences"
] | [
711,
31239,
18115,
1,
623
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
53,
8,
9,
10,
2,
24,
14,
1,
38,
16,
2,
1,
84
] | 13 | true | Domain | Pyruvate kinase, barrel | Pyruvate kinase, barrel | Pyrv_Knase_brl | 2 |
IPR015795 | 15,795 | Pyruvate kinase, C-terminal | Pyrv_Knase_C | Domain | 45,685 | false | false | Pyruvate kinase ( ) (PK) catalyses the final step in glycolysis [ , ], the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP: ADP + phosphoenolpyruvate = ATP + pyruvate The enzyme, which is found in all living organisms, requires both magnesium and potassium ions for its activ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02887"
] | [
"PK_C"
] | [
45685
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",... | [
"2.7.1.40",
"PWY-1042",
"PWY-2221",
"PWY-5484",
"PWY-5723",
"PWY-6886",
"PWY-6901",
"PWY-7003",
"PWY-7218",
"PWY-7383",
"PWY-8004",
"PWY-8404",
"R-CFA-70171",
"R-CFA-70268",
"R-DDI-6798695",
"R-DDI-70171",
"R-DDI-70268",
"R-DDI-9861718",
"R-DME-6798695",
"R-DME-70171",
"R-DME... | [
"EC:2.7.1.40",
"METACYC:PWY-1042",
"METACYC:PWY-2221",
"METACYC:PWY-5484",
"METACYC:PWY-5723",
"METACYC:PWY-6886",
"METACYC:PWY-6901",
"METACYC:PWY-7003",
"METACYC:PWY-7218",
"METACYC:PWY-7383",
"METACYC:PWY-8004",
"METACYC:PWY-8404",
"REACTOME:R-CFA-70171",
"REACTOME:R-CFA-70268",
"REAC... | 49 | [
"1a3w",
"1a3x",
"1a49",
"1a5u",
"1aqf",
"1e0t",
"1e0u",
"1f3w",
"1f3x",
"1pkl",
"1pkm",
"1pkn",
"1pky",
"1t57",
"1t5a",
"1vp8",
"1zjh",
"2e28",
"2g50",
"2vgb",
"2vgf",
"2vgg",
"2vgi",
"3bjf",
"3bjt",
"3e0v",
"3e0w",
"3eoe",
"3g2g",
"3gg8",
"3gqy",
"3gr4"... | 212 | [
"PUB00000569",
"PUB00014134",
"PUB00014243",
"PUB00024392",
"PUB00100069"
] | [
"2379684",
"11960989",
"12798932",
"10751408",
"29748232"
] | [
"Isoenzymes of pyruvate kinase.",
"Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia.",
"Pyruvate kinase: current status of regulatory and functional properties.",
"The allosteric regulation of pyruvate kinase.",
"An allostatic mechanism for M2 p... | [
1990,
2002,
2003,
2000,
2018
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctNmW2",
"unclassified sequences"
] | [
940,
28703,
15478,
1,
563
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
46,
8,
9,
11,
2,
15,
7,
1,
32,
12,
2,
1,
65
] | 13 | true | Domain | Pyruvate kinase, C-terminal | Pyruvate kinase, C-terminal | Pyrv_Knase_C | 9 |
IPR015796 | 15,796 | Impact YigZ-like | Impact_YigZ-like | Family | 9,456 | false | false | The Impact protein is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. It is evolutionary conserved fr... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00257"
] | [
"IMPACT_YIGZ"
] | [
9456
] | 1 | [] | [] | [] | 0 | [
"1vi7"
] | 1 | [
"PUB00032088",
"PUB00046141"
] | [
"15103642",
"11116084"
] | [
"Crystal structure of YIGZ, a conserved hypothetical protein from Escherichia coli k12 with a novel fold.",
"Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting."
] | [
2004,
2000
] | 2 | [
"IPR023582"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
9354,
7,
56,
39
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Impact YigZ-like | Impact YigZ-like | Impact_YigZ-like | 7 |
IPR015797 | 15,797 | NUDIX hydrolase-like domain superfamily | NUDIX_hydrolase-like_dom_sf | Homologous_superfamily | 398,767 | false | false | MutT is a small bacterial protein (~12-15Kd) involved in the GO system [ ] responsible for removing an oxidatively damaged form of guanine (8-hydroxy-guanine or 7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with near equal efficiency, lead... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF55811"
] | [
""
] | [
398767
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"R... | [
"3.6.1",
"3.6.1.-",
"PWY-5757",
"PWY-6147",
"PWY-6383",
"PWY-6797",
"PWY-7206",
"PWY-7419",
"PWY-7539",
"PWY-7719",
"PWY-7821",
"PWY-8289",
"R-BTA-1855167",
"R-BTA-196807",
"R-BTA-2393930",
"R-BTA-3299685",
"R-BTA-480985",
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-72187",
"R-B... | [
"EC:3.6.1",
"EC:3.6.1.-",
"METACYC:PWY-5757",
"METACYC:PWY-6147",
"METACYC:PWY-6383",
"METACYC:PWY-6797",
"METACYC:PWY-7206",
"METACYC:PWY-7419",
"METACYC:PWY-7539",
"METACYC:PWY-7719",
"METACYC:PWY-7821",
"METACYC:PWY-8289",
"REACTOME:R-BTA-1855167",
"REACTOME:R-BTA-196807",
"REACTOME:R... | 129 | [
"1f3y",
"1g0s",
"1g9q",
"1ga7",
"1hx3",
"1hzt",
"1i9a",
"1iry",
"1jkn",
"1jrk",
"1k26",
"1k2e",
"1khz",
"1kt9",
"1ktg",
"1mk1",
"1mp2",
"1mqe",
"1mqw",
"1mr2",
"1mut",
"1nfs",
"1nfz",
"1nqy",
"1nqz",
"1ow2",
"1ppv",
"1ppw",
"1ppx",
"1pun",
"1puq",
"1pus"... | 838 | [
"PUB00002202",
"PUB00002808",
"PUB00003856",
"PUB00004433",
"PUB00006662",
"PUB00006677"
] | [
"1328155",
"8226881",
"8170394",
"8233837",
"8810257",
"10373642"
] | [
"The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine).",
"Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.",
"Characterization of the mutX gene of Streptococcus pneum... | [
1992,
1993,
1994,
1993,
1996,
1999
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
5627,
299473,
87865,
1296,
4506
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
174,
14,
71,
34,
15,
88,
78,
18,
78,
113,
7,
9,
189
] | 13 | true | Homologous_superfamily | NUDIX hydrolase-like domain superfamily | NUDIX hydrolase-like domain superfamily | NUDIX_hydrolase-like_dom_sf | 7 |
IPR015798 | 15,798 | Copper amine oxidase, catalytic domain | Cu_amine_oxidase_C | Domain | 19,407 | false | false | This entry represents the C-terminal catalytic domain of copper amine oxidases, and has a super-sandwich fold consisting of 18 β-strands in 2 sheets [ ]. A domain with a similar structural fold can be found as the third domain in lysyl oxidase PplO [ ]. Amine oxidases (AO) are enzymes that catalyse the oxidation of a w... | [
"GO:0005507",
"GO:0008131",
"GO:0048038",
"GO:0009308"
] | [
"copper ion binding",
"primary methylamine oxidase activity",
"quinone binding",
"amine metabolic process"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 4 | [
"PFAM"
] | [
"PF01179"
] | [
"Cu_amine_oxid"
] | [
19407
] | 1 | [
"EC",
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.4.3",
"1.4.3.21",
"GenProp1402",
"R-BTA-211945",
"R-HSA-211945",
"R-HSA-6798695",
"R-MMU-211945",
"R-MMU-6798695",
"R-RNO-211945",
"R-RNO-6798695",
"R-SSC-211945",
"R-SSC-6798695"
] | [
"EC:1.4.3",
"EC:1.4.3.21",
"GP:GenProp1402",
"REACTOME:R-BTA-211945",
"REACTOME:R-HSA-211945",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-211945",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-211945",
"REACTOME:R-RNO-6798695",
"REACTOME:R-SSC-211945",
"REACTOME:R-SSC-6798695"
] | 12 | [
"1a2v",
"1av4",
"1avk",
"1avl",
"1d6u",
"1d6y",
"1d6z",
"1dyu",
"1ekm",
"1iqx",
"1iqy",
"1iu7",
"1ivu",
"1ivv",
"1ivw",
"1ivx",
"1jrq",
"1ksi",
"1lvn",
"1n9e",
"1oac",
"1pu4",
"1qaf",
"1qak",
"1qal",
"1rjo",
"1rky",
"1sih",
"1sii",
"1spu",
"1tu5",
"1ui7"... | 151 | [
"PUB00005251",
"PUB00010699",
"PUB00010700",
"PUB00010701",
"PUB00016565",
"PUB00027613"
] | [
"8591028",
"9048544",
"9405045",
"8805580",
"10576737",
"14690425"
] | [
"Crystal structure of a quinoenzyme: copper amine oxidase of Escherichia coli at 2 A resolution.",
"Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: exploring the reductive half-reaction.",
"Crystal structures of the copper-containing amine oxidase from Arthrobacter globiformis in the... | [
1995,
1997,
1997,
1996,
1999,
2003
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Klosneuvirinae",
"metagenomes"
] | [
57,
3642,
15637,
3,
68
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",... | [
45,
2,
1,
10,
18,
2,
25,
13,
2,
17
] | 10 | true | Domain | Copper amine oxidase, catalytic domain | Copper amine oxidase, catalytic domain | Cu_amine_oxidase_C | 6 |
IPR015799 | 15,799 | Influenza matrix M1, N-terminal subdomain 2 | Flu_matrix_M1_N_sub2 | Homologous_superfamily | 69,987 | false | false | Matrix protein (M1) of Influenza virus is a bifunctional membrane/RNA-binding protein that mediates the encapsidation of RNA-nucleoprotein cores into the membrane envelope. It is therefore required that M1 binds both membrane and RNA simultaneously [ ]. M1 is comprised of two domains connected by a linker sequence. The... | [
"GO:0003723",
"GO:0005198"
] | [
"RNA binding",
"structural molecule activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.10.180"
] | [
""
] | [
69987
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-168255",
"R-HSA-168275",
"R-HSA-168288",
"R-HSA-168298",
"R-HSA-168302",
"R-HSA-168303",
"R-HSA-168316",
"R-HSA-168330",
"R-HSA-168333",
"R-HSA-168336",
"R-HSA-192823"
] | [
"REACTOME:R-HSA-168255",
"REACTOME:R-HSA-168275",
"REACTOME:R-HSA-168288",
"REACTOME:R-HSA-168298",
"REACTOME:R-HSA-168302",
"REACTOME:R-HSA-168303",
"REACTOME:R-HSA-168316",
"REACTOME:R-HSA-168330",
"REACTOME:R-HSA-168333",
"REACTOME:R-HSA-168336",
"REACTOME:R-HSA-192823"
] | 11 | [
"1aa7",
"1ea3",
"2z16",
"3md2",
"3vdx",
"4d9j",
"4iq4",
"4itv",
"4ivj",
"4pus",
"4qes",
"4qf0",
"4qff",
"5cqe",
"5v6g",
"5v7b",
"5v7s",
"5v8a",
"6i3h",
"6z5j",
"6z5l",
"7jm3"
] | 22 | [
"PUB00003941",
"PUB00024486"
] | [
"9164466",
"11162800"
] | [
"Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1.",
"Combined results from solution studies on intact influenza virus M1 protein and from a new crystal form of its N-terminal domain show that M1 is an elongated monomer."
] | [
1997,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Orthomyxoviridae"
] | [
12,
69975
] | 2 | [] | [] | 0 | true | Homologous_superfamily | Influenza matrix M1, N-terminal subdomain 2 | Influenza matrix M1, N-terminal subdomain 2 | Flu_matrix_M1_N_sub2 | 7 |
IPR015800 | 15,800 | Copper amine oxidase, N2-terminal | Cu_amine_oxidase_N2 | Domain | 11,890 | false | false | This entry represents one (N2) of the two N-terminal domains (N2/N3) that share a similar structure. Amine oxidases (AO) are enzymes that catalyse the oxidation of a wide range of biogenic amines including many neurotransmitters, histamine and xenobiotic amines. There are two classes of amine oxidases: flavin-containin... | [
"GO:0005507",
"GO:0008131",
"GO:0048038",
"GO:0009308"
] | [
"copper ion binding",
"primary methylamine oxidase activity",
"quinone binding",
"amine metabolic process"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 4 | [
"PFAM"
] | [
"PF02727"
] | [
"Cu_amine_oxidN2"
] | [
11890
] | 1 | [
"EC",
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.4.3",
"1.4.3.21",
"GenProp1402",
"R-BTA-211945",
"R-HSA-211945",
"R-HSA-6798695",
"R-MMU-211945",
"R-MMU-6798695",
"R-RNO-211945",
"R-RNO-6798695",
"R-SSC-211945",
"R-SSC-6798695"
] | [
"EC:1.4.3",
"EC:1.4.3.21",
"GP:GenProp1402",
"REACTOME:R-BTA-211945",
"REACTOME:R-HSA-211945",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-211945",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-211945",
"REACTOME:R-RNO-6798695",
"REACTOME:R-SSC-211945",
"REACTOME:R-SSC-6798695"
] | 12 | [
"1a2v",
"1d6u",
"1d6y",
"1d6z",
"1dyu",
"1ekm",
"1jrq",
"1ksi",
"1lvn",
"1n9e",
"1oac",
"1pu4",
"1qaf",
"1qak",
"1qal",
"1rky",
"1spu",
"1tu5",
"1us1",
"1w2z",
"1w7c",
"2c10",
"2c11",
"2oov",
"2oqe",
"2pnc",
"2w0q",
"2wgq",
"2wo0",
"2wof",
"2woh",
"2y73"... | 56 | [
"PUB00005251",
"PUB00010699",
"PUB00010700",
"PUB00010701",
"PUB00016565"
] | [
"8591028",
"9048544",
"9405045",
"8805580",
"10576737"
] | [
"Crystal structure of a quinoenzyme: copper amine oxidase of Escherichia coli at 2 A resolution.",
"Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: exploring the reductive half-reaction.",
"Crystal structures of the copper-containing amine oxidase from Arthrobacter globiformis in the... | [
1995,
1997,
1997,
1996,
1999
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Klosneuvirinae",
"metagenomes"
] | [
45,
1146,
10679,
2,
18
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",... | [
36,
2,
1,
7,
15,
1,
13,
12,
2,
7
] | 10 | true | Domain | Copper amine oxidase, N2-terminal | Copper amine oxidase, N2-terminal | Cu_amine_oxidase_N2 | 5 |
IPR015802 | 15,802 | Copper amine oxidase, N3-terminal | Cu_amine_oxidase_N3 | Domain | 12,510 | false | false | Amine oxidases (AO) are enzymes that catalyse the oxidation of a wide range of biogenic amines including many neurotransmitters, histamine and xenobiotic amines. There are two classes of amine oxidases: flavin-containing ( ) and copper-containing ( ). Copper-containing AO act as a disulphide-linked homodimer. They cata... | [
"GO:0005507",
"GO:0008131",
"GO:0048038",
"GO:0009308"
] | [
"copper ion binding",
"primary methylamine oxidase activity",
"quinone binding",
"amine metabolic process"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 4 | [
"PFAM"
] | [
"PF02728"
] | [
"Cu_amine_oxidN3"
] | [
12510
] | 1 | [
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.4.3.21",
"GenProp1402",
"R-BTA-211945",
"R-HSA-211945",
"R-HSA-6798695",
"R-MMU-211945",
"R-MMU-6798695",
"R-RNO-211945",
"R-RNO-6798695",
"R-SSC-211945",
"R-SSC-6798695"
] | [
"EC:1.4.3.21",
"GP:GenProp1402",
"REACTOME:R-BTA-211945",
"REACTOME:R-HSA-211945",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-211945",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-211945",
"REACTOME:R-RNO-6798695",
"REACTOME:R-SSC-211945",
"REACTOME:R-SSC-6798695"
] | 11 | [
"1a2v",
"1d6u",
"1d6y",
"1d6z",
"1dyu",
"1ekm",
"1jrq",
"1ksi",
"1lvn",
"1oac",
"1pu4",
"1qaf",
"1qak",
"1qal",
"1spu",
"1tu5",
"1us1",
"1w2z",
"2c10",
"2c11",
"2oov",
"2oqe",
"2pnc",
"2w0q",
"2wgq",
"2wo0",
"2wof",
"2woh",
"2y73",
"2y74",
"3ala",
"3hi7"... | 53 | [
"PUB00005251",
"PUB00010699",
"PUB00010700",
"PUB00010701",
"PUB00016565"
] | [
"8591028",
"9048544",
"9405045",
"8805580",
"10576737"
] | [
"Crystal structure of a quinoenzyme: copper amine oxidase of Escherichia coli at 2 A resolution.",
"Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: exploring the reductive half-reaction.",
"Crystal structures of the copper-containing amine oxidase from Arthrobacter globiformis in the... | [
1995,
1997,
1997,
1996,
1999
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
54,
2778,
9628,
50
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",... | [
42,
2,
1,
8,
15,
1,
19,
11,
2,
10
] | 10 | true | Domain | Copper amine oxidase, N3-terminal | Copper amine oxidase, N3-terminal | Cu_amine_oxidase_N3 | 2 |
IPR015803 | 15,803 | Cysteine-tRNA ligase | Cys-tRNA-ligase | Family | 36,121 | false | false | Cysteine-tRNA ligase (also known as Cysteinyl-tRNA synthetase) ( ) is an alpha monomer and belongs to class Ia [ ]. It is highly specific despite not possessing the amino acid editing activity characteristic of many other tRNA ligases [ ]. Aminoacyl-tRNA synthetases (also known as aminoacyl-tRNA ligases) catalyse the a... | [
"GO:0004817",
"GO:0005524",
"GO:0006423"
] | [
"cysteine-tRNA ligase activity",
"ATP binding",
"cysteinyl-tRNA aminoacylation"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00041",
"TIGR00435"
] | [
"Cys_tRNA_synth",
"cysS"
] | [
35221,
35873
] | 2 | [
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.1.1.16",
"GenProp0258",
"R-HSA-379716",
"R-HSA-379726",
"R-HSA-9725370"
] | [
"EC:6.1.1.16",
"GP:GenProp0258",
"REACTOME:R-HSA-379716",
"REACTOME:R-HSA-379726",
"REACTOME:R-HSA-9725370"
] | 5 | [
"1li5",
"1li7",
"1u0b",
"3sp1",
"3tqo",
"6ujd",
"8qhp",
"9yru",
"9yrw",
"9yrx",
"9yrz",
"9ys0",
"9ys1",
"9ys2",
"9yt2",
"9yt3",
"9yt5"
] | 17 | [
"PUB00000386",
"PUB00000723",
"PUB00004391",
"PUB00005365",
"PUB00006477",
"PUB00007191",
"PUB00007363",
"PUB00028887",
"PUB00056788",
"PUB00079872",
"PUB00079873"
] | [
"8364025",
"8274143",
"1852601",
"2053131",
"10673435",
"2203971",
"10447505",
"12032090",
"1992490",
"10704480",
"12458790"
] | [
"Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.",
"The aminoacyl-tRNA synthetase family: modules at work.",
"Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.",
"Classes of aminoacyl-tRNA synthetases and the establ... | [
1993,
1993,
1991,
1991,
2000,
1990,
1999,
2002,
1991,
2000,
2002
] | 11 | [
"IPR024909"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimiviridae",
"unclassified sequences"
] | [
841,
26864,
7791,
9,
616
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
11,
4,
4,
2,
1,
8,
7,
1,
9,
13,
1,
1,
28
] | 13 | true | Family | Cysteine-tRNA ligase | Cysteine-tRNA ligase | Cys-tRNA-ligase | 1 |
IPR015806 | 15,806 | Pyruvate kinase, insert domain superfamily | Pyrv_Knase_insert_dom_sf | Homologous_superfamily | 47,762 | false | false | Pyruvate kinase ( ) (PK) catalyses the final step in glycolysis [ , ], the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP: ADP + phosphoenolpyruvate = ATP + pyruvate The enzyme, which is found in all living organisms, requires both magnesium and potassium ions for its activ... | [
"GO:0004743",
"GO:0006096"
] | [
"pyruvate kinase activity",
"glycolytic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"CATHGENE3D"
] | [
"G3DSA:2.40.33.10"
] | [
""
] | [
47762
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",... | [
"2.7.1.40",
"PWY-1042",
"PWY-2221",
"PWY-5484",
"PWY-5723",
"PWY-6886",
"PWY-6901",
"PWY-7003",
"PWY-7218",
"PWY-7383",
"PWY-8004",
"PWY-8404",
"R-CFA-70171",
"R-CFA-70268",
"R-DDI-6798695",
"R-DDI-70171",
"R-DDI-70268",
"R-DDI-9861718",
"R-DME-6798695",
"R-DME-70171",
"R-DME... | [
"EC:2.7.1.40",
"METACYC:PWY-1042",
"METACYC:PWY-2221",
"METACYC:PWY-5484",
"METACYC:PWY-5723",
"METACYC:PWY-6886",
"METACYC:PWY-6901",
"METACYC:PWY-7003",
"METACYC:PWY-7218",
"METACYC:PWY-7383",
"METACYC:PWY-8004",
"METACYC:PWY-8404",
"REACTOME:R-CFA-70171",
"REACTOME:R-CFA-70268",
"REAC... | 49 | [
"1a3w",
"1a3x",
"1a49",
"1a5u",
"1aqf",
"1e0t",
"1e0u",
"1f3w",
"1f3x",
"1pkl",
"1pkm",
"1pkn",
"1pky",
"1t5a",
"1zjh",
"2e28",
"2g50",
"2vgb",
"2vgf",
"2vgg",
"2vgi",
"3bjf",
"3bjt",
"3e0v",
"3e0w",
"3eoe",
"3g2g",
"3gg8",
"3gqy",
"3gr4",
"3h6o",
"3hqn"... | 170 | [
"PUB00000569",
"PUB00014134",
"PUB00014243",
"PUB00024392",
"PUB00100069"
] | [
"2379684",
"11960989",
"12798932",
"10751408",
"29748232"
] | [
"Isoenzymes of pyruvate kinase.",
"Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia.",
"Pyruvate kinase: current status of regulatory and functional properties.",
"The allosteric regulation of pyruvate kinase.",
"An allostatic mechanism for M2 p... | [
1990,
2002,
2003,
2000,
2018
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctNmW2",
"unclassified sequences"
] | [
694,
30373,
16182,
1,
512
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
52,
8,
9,
8,
2,
18,
11,
1,
35,
15,
2,
1,
67
] | 13 | true | Homologous_superfamily | Pyruvate kinase, insert domain superfamily | Pyruvate kinase, insert domain superfamily | Pyrv_Knase_insert_dom_sf | 8 |
IPR015807 | 15,807 | Histidine-tRNA ligase | His-tRNA-ligase | Family | 33,536 | false | false | Histidine-tRNA ligase (also known as histidyl-tRNA synthetase) ( ) is an alpha2 dimer that belongs to class IIa. Every completed genome includes a histidine-tRNA ligase. Apparent second copies from Bacillus subtilis, Synechocystis sp. (strain PCC 6803), and Aquifex aeolicus are slightly shorter, more closely related to... | [
"GO:0004821",
"GO:0005524",
"GO:0006427"
] | [
"histidine-tRNA ligase activity",
"ATP binding",
"histidyl-tRNA aminoacylation"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00127",
"TIGR00442"
] | [
"His_tRNA_synth",
"hisS"
] | [
28488,
33088
] | 2 | [
"EC",
"GP",
"REACTOME",
"REACTOME"
] | [
"6.1.1.21",
"GenProp0258",
"R-HSA-379716",
"R-HSA-379726"
] | [
"EC:6.1.1.21",
"GP:GenProp0258",
"REACTOME:R-HSA-379716",
"REACTOME:R-HSA-379726"
] | 4 | [
"1adj",
"1ady",
"1h4v",
"1htt",
"1kmm",
"1kmn",
"1qe0",
"1wu7",
"2el9",
"3hri",
"3hrk",
"3lc0",
"3net",
"4e51",
"4g84",
"4g85",
"4phc",
"4rdx",
"4x5o",
"4yp0",
"4ypf",
"4yrc",
"4yre",
"4yrf",
"4yrg",
"4yri",
"4yrj",
"4yrk",
"4yrl",
"4yrm",
"4yrn",
"4yro"... | 41 | [] | [] | [] | [] | 0 | [
"IPR004516"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviricetes",
"unclassified sequences"
] | [
911,
26624,
5482,
11,
508
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
12,
1,
2,
3,
1,
8,
7,
1,
6,
6,
1,
1,
18
] | 13 | true | Family | Histidine-tRNA ligase | Histidine-tRNA ligase | His-tRNA-ligase | 1 |
IPR015810 | 15,810 | Photosynthetic reaction centre, H subunit, N-terminal | Photo_RC_H_N | Domain | 652 | false | false | This entry represents the N-terminal domain of the photosynthetic reaction centre H subunit, which includes the transmembrane domain and part of the cytoplasmic domain [ ]. The photosynthetic apparatus in non-oxygenic bacteria consists of light-harvesting (LH) protein-pigment complexes LH1 and LH2, which use carotenoid... | [
"GO:0019684",
"GO:0030077"
] | [
"photosynthesis, light reaction",
"plasma membrane light-harvesting complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF03967"
] | [
"PRCH"
] | [
652
] | 1 | [] | [] | [] | 0 | [
"1aig",
"1aij",
"1ds8",
"1dv3",
"1dv6",
"1dxr",
"1e14",
"1e6d",
"1eys",
"1f6n",
"1fnp",
"1fnq",
"1jgw",
"1jgx",
"1jgy",
"1jgz",
"1jh0",
"1k6l",
"1k6n",
"1kby",
"1l9b",
"1l9j",
"1m3x",
"1mps",
"1ogv",
"1pcr",
"1prc",
"1pss",
"1pst",
"1qov",
"1r2c",
"1rg5"... | 219 | [
"PUB00014111",
"PUB00014116",
"PUB00014117",
"PUB00015279",
"PUB00015395",
"PUB00034760",
"PUB00034761",
"PUB00034762"
] | [
"11095707",
"11005826",
"10611277",
"2676514",
"12872158",
"15329728",
"16931113",
"8027023"
] | [
"Crystal structures of photosynthetic reaction center and high-potential iron-sulfur protein from Thermochromatium tepidum: thermostability and electron transfer.",
"Structural basis of the drastically increased initial electron transfer rate in the reaction center from a Rhodopseudomonas viridis mutant described... | [
2000,
2000,
1999,
1989,
2003,
2004,
2006,
1994
] | 8 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"freshwater sediment metagenome"
] | [
648,
3,
1
] | 3 | [] | [] | 0 | true | Domain | Photosynthetic reaction centre, H subunit, N-terminal | Photosynthetic reaction centre, H subunit, N-terminal | Photo_RC_H_N | 4 |
IPR015811 | 15,811 | Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 1 | Me_CoM_Rdtase_asu_N_sub1 | Homologous_superfamily | 822 | false | false | Methyl-coenzyme M reductase (MCR) catalyses the reduction of methyl-coenzyme M (CH3-SCoM) and coenzyme B (HS-CoB) to methane and the corresponding heterosulphide CoM-S-S-CoB ( ), the final step in methane biosynthesis. This reaction proceeds under anaerobic conditions by methanogenic Archaea [ ], and requires a nickel-... | [
"GO:0050524",
"GO:0015948"
] | [
"coenzyme-B sulfoethylthiotransferase activity",
"methanogenesis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"CATHGENE3D"
] | [
"G3DSA:3.90.390.10"
] | [
""
] | [
822
] | 1 | [
"EC"
] | [
"2.8.4.1"
] | [
"EC:2.8.4.1"
] | 1 | [
"1e6v",
"1e6y",
"1hbm",
"1hbn",
"1hbo",
"1hbu",
"1mro",
"3m1v",
"3m2r",
"3m2u",
"3m2v",
"3m30",
"3m32",
"3pot",
"3sqg",
"5a0y",
"5a8k",
"5a8r",
"5a8w",
"5g0r",
"5n1q",
"5n28",
"5n2a",
"7b1s",
"7b2c",
"7b2h",
"7nkg",
"7suc",
"7sxm",
"8gf5",
"8gf6",
"8s7v"... | 39 | [
"PUB00006391",
"PUB00010614",
"PUB00035993",
"PUB00035994"
] | [
"9367957",
"11491299",
"16260307",
"16234924"
] | [
"Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.",
"On the mechanism of biological methane formation: structural evidence for conformational changes in methyl-coenzyme M reductase upon substrate binding.",
"Methyl-coenzyme M reductase genes: unique functional ma... | [
1997,
2001,
2005,
2005
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"ecological metagenomes"
] | [
817,
5
] | 2 | [] | [] | 0 | true | Homologous_superfamily | Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 1 | Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 1 | Me_CoM_Rdtase_asu_N_sub1 | 1 |
IPR015812 | 15,812 | Integrin beta subunit | Integrin_bsu | Family | 17,132 | false | false | This entry represents the family of integrin beta subunit proteins and integrin beta-like proteins. It also includes integrin beta-pat-3 (pat-3) from Caenorhabditis elegans. Integrin alpha ina-1/beta pat-3 are receptors for laminin. Pat-3 is required for muscle development and maintenance and plays a role in axon regen... | [] | [] | [] | 0 | [
"PIRSF",
"PRINTS",
"PANTHER"
] | [
"PIRSF002512",
"PR01186",
"PTHR10082"
] | [
"Integrin_B",
"INTEGRINB",
""
] | [
9356,
14988,
17013
] | 3 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00216",
"R-BTA-1566948",
"R-BTA-166016",
"R-BTA-198933",
"R-BTA-202733",
"R-BTA-2129379",
"R-BTA-216083",
"R-BTA-2173789",
"R-BTA-3000178",
"R-BTA-6798695",
"R-CEL-114608",
"R-CEL-1236973",
"R-CEL-1566977",
"R-CEL-198933",
"R-CEL-202733",
"R-CEL-210991",
"R-CEL-2129379",
"R-CE... | [
"PROSITEDOC:PDOC00216",
"REACTOME:R-BTA-1566948",
"REACTOME:R-BTA-166016",
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-202733",
"REACTOME:R-BTA-2129379",
"REACTOME:R-BTA-216083",
"REACTOME:R-BTA-2173789",
"REACTOME:R-BTA-3000178",
"REACTOME:R-BTA-6798695",
"REACTOME:R-CEL-114608",
"REACTOME:R-CEL... | 171 | [
"1jv2",
"1l5g",
"1m1x",
"1tye",
"1u8c",
"1yuk",
"2iue",
"2k9j",
"2knc",
"2kv9",
"2l91",
"2n9y",
"2p26",
"2p28",
"2rmz",
"2rn0",
"2vc2",
"2vdk",
"2vdl",
"2vdm",
"2vdn",
"2vdo",
"2vdp",
"2vdq",
"2vdr",
"3fcs",
"3fcu",
"3ije",
"3k6s",
"3k71",
"3k72",
"3nid"... | 180 | [
"PUB00000811",
"PUB00001505",
"PUB00006148",
"PUB00009789",
"PUB00015915",
"PUB00015985",
"PUB00035000",
"PUB00035002",
"PUB00057248",
"PUB00101472",
"PUB00160072",
"PUB00160424",
"PUB00160425"
] | [
"3028640",
"2199285",
"9009218",
"12297042",
"14689578",
"2467745",
"12361595",
"12234368",
"12388743",
"22253611",
"11572973",
"31109965",
"28510180"
] | [
"Integrins: a family of cell surface receptors.",
"Integrins and other cell adhesion molecules.",
"A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain.",
"Integrins: bidirectional, allosteric signaling machines.",
"... | [
1987,
1990,
1997,
2002,
2004,
1989,
2002,
2002,
2002,
2012,
2001,
2019,
2014
] | 13 | [] | [
"IPR012013"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota"
] | [
54,
17078
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
34,
8,
97,
29,
40
] | 6 | true | Family | Integrin beta subunit | Integrin beta subunit | Integrin_bsu | 5 |
IPR015813 | 15,813 | Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily | Pyrv/PenolPyrv_kinase-like_dom | Homologous_superfamily | 266,070 | false | false | Pyruvate kinase controls the exit from the glysolysis pathway, catalysing the transfer of phosphate from phosphooenolpyruvate (PEP) to ADP. Mammalian pyruvate kinase is a homotetramer, where each polypeptide subunit consists of four domains: N-terminal, A domain, B domain and C-terminal. Activation of the enzyme is bel... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF51621"
] | [
""
] | [
266070
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CFA-70171",
"R-CFA-70268",
"R-DDI-6798695",
"R-DDI-70171",
"R-DDI-70268",
"R-DDI-9861718",
"R-DME-6798695",
"R-DME-70171",
"R-DME-70268",
"R-DME-9861718",
"R-GGA-352882",
"R-GGA-6798695",
"R-GGA-70171",
"R-GGA-70268",
"R-GGA-9861718",
"R-HSA-163765",
"R-HSA-210745",
"R-HSA-67986... | [
"REACTOME:R-CFA-70171",
"REACTOME:R-CFA-70268",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-70171",
"REACTOME:R-DDI-70268",
"REACTOME:R-DDI-9861718",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-70171",
"REACTOME:R-DME-70268",
"REACTOME:R-DME-9861718",
"REACTOME:R-GGA-352882",
"REACTOME:R-GGA-67986... | 37 | [
"1a3w",
"1a3x",
"1a49",
"1a5u",
"1aqf",
"1dik",
"1dqu",
"1dxe",
"1dxf",
"1e0t",
"1e0u",
"1f3w",
"1f3x",
"1f61",
"1f8i",
"1f8m",
"1fiy",
"1ggo",
"1igw",
"1izc",
"1jde",
"1jqn",
"1jqo",
"1kbl",
"1kc7",
"1m1b",
"1m3u",
"1mum",
"1o5q",
"1o66",
"1o68",
"1oqf"... | 413 | [
"PUB00022133",
"PUB00024777",
"PUB00026498",
"PUB00026675",
"PUB00028676",
"PUB00035541"
] | [
"12906829",
"11563914",
"12467579",
"11790099",
"11526312",
"7064730"
] | [
"Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites.",
"Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase.",
"Crystal structures of C4 form maize and quaternary complex of E. col... | [
2003,
2001,
2002,
2002,
2001,
1982
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
5068,
206054,
50871,
13,
4064
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
125,
10,
12,
8,
14,
29,
16,
8,
96,
19,
5,
3,
289
] | 13 | true | Homologous_superfamily | Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily | Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily | Pyrv/PenolPyrv_kinase-like_dom | 2 |
IPR015814 | 15,814 | Phosphogluconate dehydrogenase, NAD-binding, putative, C-terminal | Pgluconate_DH_NAD-bd_C | Domain | 4,079 | false | false | This domain has been found in a number of eukaryotic and prokaryotic proteins, some of which are predicted to be 6-phosphogluconate dehydrogenase, NAD-binding proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF09130"
] | [
"DUF1932"
] | [
4079
] | 1 | [] | [] | [] | 0 | [
"1i36",
"3qsg",
"4ezb"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
30,
2874,
1140,
35
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Phosphogluconate dehydrogenase, NAD-binding, putative, C-terminal | Phosphogluconate dehydrogenase, NAD-binding, putative, C-terminal | Pgluconate_DH_NAD-bd_C | 6 |
IPR015815 | 15,815 | 3-hydroxyisobutyrate dehydrogenase-related | HIBADH-related | Family | 64,980 | false | false | This entry contains related reductases/dehydrogenases: 3-hydroxyisobutyrate dehydrogenase (HIBADH) ( ) catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate [ ]. In eukaryotes, it is a homodimeric mitochondrial protein involved in valine catabolism. In Pseudomonas aeruginosa [ ] (gene ... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF"
] | [
"PIRSF000103"
] | [
"HIBADH"
] | [
64980
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.1.1",
"R-BTA-70895",
"R-CEL-70895",
"R-DDI-70895",
"R-DME-70895",
"R-HSA-70895",
"R-MMU-70895",
"R-RNO-70895"
] | [
"EC:1.1.1",
"REACTOME:R-BTA-70895",
"REACTOME:R-CEL-70895",
"REACTOME:R-DDI-70895",
"REACTOME:R-DME-70895",
"REACTOME:R-HSA-70895",
"REACTOME:R-MMU-70895",
"REACTOME:R-RNO-70895"
] | 8 | [
"1vpd",
"1wp4",
"1yb4",
"2cvz",
"2gf2",
"2i9p",
"2uyy",
"3cky",
"3doj",
"3g0o",
"3l6d",
"3obb",
"3pdu",
"3pef",
"3q3c",
"3qha",
"3w6u",
"3w6z",
"3ws7",
"3zgy",
"3zhb",
"4d3d",
"4d3f",
"4d3s",
"4dll",
"4ezb",
"4gbj",
"4oqy",
"4oqz",
"5a9r",
"5a9s",
"5a9t"... | 122 | [
"PUB00002541",
"PUB00002721",
"PUB00051037",
"PUB00057919",
"PUB00085179"
] | [
"2647728",
"1339433",
"18680749",
"16352664",
"27402745"
] | [
"Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases.",
"Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO encoding methylmalonate-semialdehyde dehydrogenase and 3-hydroxyi... | [
1989,
1992,
2008,
2006,
2016
] | 5 | [] | [
"IPR006398",
"IPR011548",
"IPR030876",
"IPR050006"
] | 0 | 4 | 0 | [
"Archaea",
"Bacteria",
"Escherichia phage RCS47",
"Eukaryota",
"unclassified sequences"
] | [
405,
55266,
1,
8807,
501
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
20,
1,
2,
2,
4,
2,
2,
2,
10,
4,
21
] | 11 | true | Family | 3-hydroxyisobutyrate dehydrogenase-related | 3-hydroxyisobutyrate dehydrogenase-related | HIBADH-related | 2 |
IPR015816 | 15,816 | Vitellinogen, beta-sheet N-terminal | Vitellinogen_b-sht_N | Homologous_superfamily | 10,724 | false | false | Vitellinogen precursors provide the major egg yolk proteins that are a source of nutrients during early development of oviparous vertebrates and invertebrates. Vitellinogen precursors are multi-domain apolipoproteins that are cleaved into distinct yolk proteins. Different vitellinogen precursors exist, which are compos... | [
"GO:0005319",
"GO:0006869"
] | [
"lipid transporter activity",
"lipid transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"CATHGENE3D"
] | [
"G3DSA:2.30.230.10"
] | [
""
] | [
10724
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-8964041",
"R-DRE-8964041",
"R-HSA-202733",
"R-HSA-3000471",
"R-HSA-3000480",
"R-HSA-3000484",
"R-HSA-3000497",
"R-HSA-381426",
"R-HSA-432142",
"R-HSA-5686938",
"R-HSA-8856825",
"R-HSA-8856828",
"R-HSA-8866423",
"R-HSA-8957275",
"R-HSA-8963888",
"R-HSA-8963901",
"R-HSA-8964026"... | [
"REACTOME:R-DME-8964041",
"REACTOME:R-DRE-8964041",
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-3000471",
"REACTOME:R-HSA-3000480",
"REACTOME:R-HSA-3000484",
"REACTOME:R-HSA-3000497",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-432142",
"REACTOME:R-HSA-5686938",
"REACTOME:R-HSA-8856825",
"REACTOME:R... | 63 | [
"1lsh",
"6i7s",
"8eoj",
"9bd1",
"9bd8",
"9bde",
"9bdt",
"9coo",
"9e9r",
"9ea7",
"9eag",
"9enr",
"9ens"
] | 13 | [
"PUB00005307",
"PUB00007158",
"PUB00035546",
"PUB00035547",
"PUB00035548",
"PUB00035549"
] | [
"9687371",
"12135361",
"17314313",
"9692232",
"17189915",
"8838584"
] | [
"The structural basis of lipid interactions in lipovitellin, a soluble lipoprotein.",
"Lipid-protein interactions in lipovitellin.",
"Vertebrate yolk complexes and the functional implications of phosvitins and other subdomains in vitellogenins.",
"Molecular characteristics of insect vitellogenins and vitellog... | [
1998,
2002,
2007,
1998,
2006,
1996
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
7,
10717
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
27,
7,
14,
5,
5
] | 6 | true | Homologous_superfamily | Vitellinogen, beta-sheet N-terminal | Vitellinogen, beta-sheet N-terminal | Vitellinogen_b-sht_N | 1 |
IPR015817 | 15,817 | Vitellinogen, open beta-sheet, subdomain 1 | Vitellinogen_open_b-sht_sub1 | Homologous_superfamily | 5,201 | false | false | Vitellinogen precursors provide the major egg yolk proteins that are a source of nutrients during early development of oviparous vertebrates and invertebrates. Vitellinogen precursors are multi-domain apolipoproteins that are cleaved into distinct yolk proteins. Different vitellinogen precursors exist, which are compos... | [
"GO:0005319"
] | [
"lipid transporter activity"
] | [
"molecular_function"
] | 1 | [
"CATHGENE3D"
] | [
"G3DSA:2.20.50.20"
] | [
""
] | [
5201
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-202733",
"R-HSA-3000471",
"R-HSA-3000480",
"R-HSA-3000484",
"R-HSA-3000497",
"R-HSA-381426",
"R-HSA-432142",
"R-HSA-5686938",
"R-HSA-8856825",
"R-HSA-8856828",
"R-HSA-8866423",
"R-HSA-8957275",
"R-HSA-8963888",
"R-HSA-8963901",
"R-HSA-8964026",
"R-HSA-8964038",
"R-HSA-8964041"... | [
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-3000471",
"REACTOME:R-HSA-3000480",
"REACTOME:R-HSA-3000484",
"REACTOME:R-HSA-3000497",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-432142",
"REACTOME:R-HSA-5686938",
"REACTOME:R-HSA-8856825",
"REACTOME:R-HSA-8856828",
"REACTOME:R-HSA-8866423",
"REACTOME:R... | 20 | [
"1lsh",
"9bd1",
"9bd8",
"9bde",
"9bdt",
"9coo",
"9e9r",
"9ea7",
"9eag"
] | 9 | [
"PUB00005307",
"PUB00007158",
"PUB00035546",
"PUB00035547",
"PUB00035548",
"PUB00035549"
] | [
"9687371",
"12135361",
"17314313",
"9692232",
"17189915",
"8838584"
] | [
"The structural basis of lipid interactions in lipovitellin, a soluble lipoprotein.",
"Lipid-protein interactions in lipovitellin.",
"Vertebrate yolk complexes and the functional implications of phosvitins and other subdomains in vitellogenins.",
"Molecular characteristics of insect vitellogenins and vitellog... | [
1998,
2002,
2007,
1998,
2006,
1996
] | 6 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
5201
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens"
] | [
22,
4,
5
] | 3 | true | Homologous_superfamily | Vitellinogen, open beta-sheet, subdomain 1 | Vitellinogen, open beta-sheet, subdomain 1 | Vitellinogen_open_b-sht_sub1 | 6 |
IPR015819 | 15,819 | Lipid transport protein, beta-sheet shell | Lipid_transp_b-sht_shell | Homologous_superfamily | 11,882 | false | false | This superfamily represents β-sheet shell domains found in lipid transport proteins such as vitellinogen. Vitellinogen precursors provide the major egg yolk proteins that are a source of nutrients during early development of oviparous vertebrates and invertebrates. Vitellinogen precursors are multi-domain apolipoprotei... | [
"GO:0005319",
"GO:0006869"
] | [
"lipid transporter activity",
"lipid transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"SSF"
] | [
"SSF56968"
] | [
""
] | [
11882
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-8964041",
"R-DRE-8964041",
"R-HSA-202733",
"R-HSA-3000471",
"R-HSA-3000480",
"R-HSA-3000484",
"R-HSA-3000497",
"R-HSA-381426",
"R-HSA-432142",
"R-HSA-5686938",
"R-HSA-8856825",
"R-HSA-8856828",
"R-HSA-8866423",
"R-HSA-8957275",
"R-HSA-8963888",
"R-HSA-8963901",
"R-HSA-8964026"... | [
"REACTOME:R-DME-8964041",
"REACTOME:R-DRE-8964041",
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-3000471",
"REACTOME:R-HSA-3000480",
"REACTOME:R-HSA-3000484",
"REACTOME:R-HSA-3000497",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-432142",
"REACTOME:R-HSA-5686938",
"REACTOME:R-HSA-8856825",
"REACTOME:R... | 63 | [
"1lsh",
"6i7s",
"8eoj",
"9bd1",
"9bd8",
"9bde",
"9bdt",
"9coo",
"9e9r",
"9ea7",
"9eag",
"9enr",
"9ens"
] | 13 | [
"PUB00007158",
"PUB00035546"
] | [
"12135361",
"17314313"
] | [
"Lipid-protein interactions in lipovitellin.",
"Vertebrate yolk complexes and the functional implications of phosvitins and other subdomains in vitellogenins."
] | [
2002,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
8,
11874
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
29,
7,
14,
5,
5
] | 6 | true | Homologous_superfamily | Lipid transport protein, beta-sheet shell | Lipid transport protein, beta-sheet shell | Lipid_transp_b-sht_shell | 1 |
IPR015823 | 15,823 | Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 2 | Me_CoM_Rdtase_asu_N_sub2 | Homologous_superfamily | 2,191 | false | false | Methyl-coenzyme M reductase (MCR) catalyses the reduction of methyl-coenzyme M (CH3-SCoM) and coenzyme B (HS-CoB) to methane and the corresponding heterosulphide CoM-S-S-CoB ( ), the final step in methane biosynthesis. This reaction proceeds under anaerobic conditions by methanogenic Archaea [ ], and requires a nickel-... | [
"GO:0050524",
"GO:0015948"
] | [
"coenzyme-B sulfoethylthiotransferase activity",
"methanogenesis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"CATHGENE3D"
] | [
"G3DSA:3.30.70.470"
] | [
""
] | [
2191
] | 1 | [
"EC"
] | [
"2.8.4.1"
] | [
"EC:2.8.4.1"
] | 1 | [
"1e6v",
"1e6y",
"1hbm",
"1hbn",
"1hbo",
"1hbu",
"1mro",
"3m1v",
"3m2r",
"3m2u",
"3m2v",
"3m30",
"3m32",
"3pot",
"3sqg",
"5a0y",
"5a8k",
"5a8r",
"5a8w",
"5g0r",
"5n1q",
"5n28",
"5n2a",
"7b1s",
"7b2c",
"7b2h",
"7nkg",
"7suc",
"7sxm",
"8gf5",
"8gf6",
"8s7v"... | 39 | [
"PUB00006391",
"PUB00010614",
"PUB00035993",
"PUB00035994"
] | [
"9367957",
"11491299",
"16260307",
"16234924"
] | [
"Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.",
"On the mechanism of biological methane formation: structural evidence for conformational changes in methyl-coenzyme M reductase upon substrate binding.",
"Methyl-coenzyme M reductase genes: unique functional ma... | [
1997,
2001,
2005,
2005
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"unclassified sequences",
"uncultured rumen bacterium"
] | [
2033,
141,
17
] | 3 | [] | [] | 0 | true | Homologous_superfamily | Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 2 | Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 2 | Me_CoM_Rdtase_asu_N_sub2 | 4 |
IPR015824 | 15,824 | Phosphoglycerate kinase, N-terminal | Phosphoglycerate_kinase_N | Homologous_superfamily | 38,125 | false | false | Phosphoglycerate kinase ( ) (PGK) is an enzyme that catalyses the formation of ATP to ADP and vice versa. In the second step of the second phase in glycolysis, 1,3-diphosphoglycerate is converted to 3-phosphoglycerate, forming one molecule of ATP. If the reverse were to occur, one molecule of ADP would be formed. This ... | [
"GO:0004618",
"GO:0006096"
] | [
"phosphoglycerate kinase activity",
"glycolytic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"CATHGENE3D"
] | [
"G3DSA:3.40.50.1260"
] | [
""
] | [
38125
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTO... | [
"2.7.2.3",
"PWY-1042",
"PWY-5484",
"PWY-6886",
"PWY-6901",
"PWY-7003",
"PWY-8004",
"PWY-8404",
"R-BTA-70171",
"R-BTA-70263",
"R-CEL-70171",
"R-CEL-70263",
"R-DDI-70171",
"R-DDI-70263",
"R-DME-70171",
"R-DME-70263",
"R-GGA-352875",
"R-GGA-352882",
"R-HSA-70171",
"R-HSA-70263",
... | [
"EC:2.7.2.3",
"METACYC:PWY-1042",
"METACYC:PWY-5484",
"METACYC:PWY-6886",
"METACYC:PWY-6901",
"METACYC:PWY-7003",
"METACYC:PWY-8004",
"METACYC:PWY-8404",
"REACTOME:R-BTA-70171",
"REACTOME:R-BTA-70263",
"REACTOME:R-CEL-70171",
"REACTOME:R-CEL-70263",
"REACTOME:R-DDI-70171",
"REACTOME:R-DDI-... | 33 | [
"13pk",
"16pk",
"1fw8",
"1hdi",
"1kf0",
"1ltk",
"1php",
"1qpg",
"1v6s",
"1vjc",
"1vjd",
"1vpe",
"1zmr",
"2cun",
"2ie8",
"2p9q",
"2p9t",
"2paa",
"2wzb",
"2wzc",
"2wzd",
"2x13",
"2x14",
"2x15",
"2xe6",
"2xe7",
"2xe8",
"2y3i",
"2ybe",
"2zgv",
"3c39",
"3c3a"... | 68 | [
"PUB00006255",
"PUB00006482",
"PUB00006511"
] | [
"2124145",
"6689547",
"10593256"
] | [
"Flexibility and folding of phosphoglycerate kinase.",
"Phosphoglycerate kinase abnormalities: functional, structural and genomic aspects.",
"Folding funnels and conformational transitions via hinge-bending motions."
] | [
1990,
1983,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
956,
26516,
9799,
2,
852
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
8,
1,
1,
6,
1,
10,
4,
1,
16,
8,
1,
1,
33
] | 13 | true | Homologous_superfamily | Phosphoglycerate kinase, N-terminal | Phosphoglycerate kinase, N-terminal | Phosphoglycerate_kinase_N | 2 |
IPR015827 | 15,827 | Alpha-(1,6)-fucosyltransferase | Fut8 | Family | 1,153 | false | false | Alpha-(1,6)-fucosyltransferase Fut8 catalyses the alpha1,6-linkage of a fucose residue from a donor substrate to N-linked oligosaccharides on glycoproteins in a process called core fucosylation, which is crucial for growth factor receptor-mediated biological functions. Fut8-deficient mice show severe growth retardation... | [
"GO:0008424",
"GO:0009101",
"GO:0016020",
"GO:0032580"
] | [
"glycoprotein 6-alpha-L-fucosyltransferase activity",
"glycoprotein biosynthetic process",
"membrane",
"Golgi cisterna membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PIRSF"
] | [
"PIRSF000472"
] | [
"Alpha1_6FUT_euk"
] | [
1153
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.1.68",
"PWY-7426",
"R-CEL-975578",
"R-DME-975578",
"R-HSA-9694548",
"R-HSA-975578",
"R-MMU-975578",
"R-RNO-975578",
"R-XTR-975578"
] | [
"EC:2.4.1.68",
"METACYC:PWY-7426",
"REACTOME:R-CEL-975578",
"REACTOME:R-DME-975578",
"REACTOME:R-HSA-9694548",
"REACTOME:R-HSA-975578",
"REACTOME:R-MMU-975578",
"REACTOME:R-RNO-975578",
"REACTOME:R-XTR-975578"
] | 9 | [
"2de0",
"6vlf",
"6vlg",
"6x5h",
"6x5r",
"6x5t",
"6x5u"
] | 7 | [
"PUB00040227",
"PUB00085809",
"PUB00085810",
"PUB00085811"
] | [
"17172260",
"17132494",
"21951615",
"14568171"
] | [
"Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8.",
"Phenotype changes of Fut8 knockout mouse: core fucosylation is crucial for the function of growth factor receptor(s).",
"Alteration in N-glycomics during mouse aging: a role for FUT8.",
"Expression of alpha1,6-fucosyltransferase (FUT8) in p... | [
2007,
2006,
2011,
2003
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1153
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
7,
1,
3,
2,
4
] | 6 | true | Family | Alpha-(1,6)-fucosyltransferase | Alpha-(1,6)-fucosyltransferase | Fut8 | 3 |
IPR015828 | 15,828 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | NDUFA10 | Family | 1,652 | false | false | This entry represents the subunit 10 (also known as CI-42kD) of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). It is an accessory subunit that is believed not to be involved in catalysis [ ]. | [
"GO:0006120"
] | [
"mitochondrial electron transport, NADH to ubiquinone"
] | [
"biological_process"
] | 1 | [
"PIRSF",
"CDD"
] | [
"PIRSF000543",
"cd02030"
] | [
"NADH_UQ_42KD",
"NDUO42"
] | [
1596,
1162
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-611105",
"R-DME-6799198",
"R-HSA-611105",
"R-HSA-6799198",
"R-MMU-611105",
"R-MMU-6799198",
"R-RNO-611105",
"R-RNO-6799198"
] | [
"REACTOME:R-DME-611105",
"REACTOME:R-DME-6799198",
"REACTOME:R-HSA-611105",
"REACTOME:R-HSA-6799198",
"REACTOME:R-MMU-611105",
"REACTOME:R-MMU-6799198",
"REACTOME:R-RNO-611105",
"REACTOME:R-RNO-6799198"
] | 8 | [
"5gpn",
"5gup",
"5lnk",
"5o31",
"5xtc",
"5xtd",
"5xth",
"5xti",
"6g2j",
"6g72",
"6q9b",
"6qa9",
"6qbx",
"6qc2",
"6qc3",
"6qc4",
"6qc5",
"6qc6",
"6qc7",
"6qc8",
"6qc9",
"6qca",
"6qcf",
"6zka",
"6zkb",
"6zkc",
"6zkd",
"6zke",
"6zkf",
"6zkg",
"6zkh",
"6zki"... | 205 | [
"PUB00005074",
"PUB00011390",
"PUB00043561",
"PUB00045437"
] | [
"1470679",
"9878551",
"10940377",
"18394423"
] | [
"The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.",
"cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.",
"The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubuni... | [
1992,
1998,
2000,
2008
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1652
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
25,
1,
13
] | 6 | true | Family | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | NDUFA10 | 4 |
IPR015832 | 15,832 | MTH_1235/AF_1403/MJ1458 | MTH_1235-like | Family | 195 | false | false | This entry includes Uncharacterized protein MTH_1235, AF_1403 and MJ1458. They are predicted ligand-binding protein with an N-terminal ACT domain, AF1403 type. The ACT domain generally has a regulatory role that is linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF006363"
] | [
"UCP006363_ACT"
] | [
195
] | 1 | [] | [] | [] | 0 | [
"1y7p"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
167,
19,
9
] | 3 | [] | [] | 0 | true | Family | MTH_1235/AF_1403/MJ1458 | MTH_1235/AF_1403/MJ1458 | MTH_1235-like | 2 |
IPR015833 | 15,833 | DNA-directed DNA polymerase, family B, mitochondrial linear plasmid | DNA-dir_DNA_pol_B_mt_lin_plsmd | Family | 79 | false | false | This group represents a family B type DNA-directed DNA polymerase which is encoded on mitochondrial linear plasmids [ ]. | [
"GO:0003677",
"GO:0003887",
"GO:0006260",
"GO:0005739"
] | [
"DNA binding",
"DNA-directed DNA polymerase activity",
"DNA replication",
"mitochondrion"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PIRSF"
] | [
"PIRSF006517"
] | [
"DPol_mt_plasmid"
] | [
79
] | 1 | [
"EC"
] | [
"2.7.7.7"
] | [
"EC:2.7.7.7"
] | 1 | [] | 0 | [
"PUB00016902"
] | [
"1782679"
] | [
"The linear plasmid pMC3-2 from Morchella conica is structurally related to adenoviruses."
] | [
1991
] | 1 | [
"IPR006172"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
79
] | 1 | [
"Zea mays"
] | [
5
] | 1 | true | Family | DNA-directed DNA polymerase, family B, mitochondrial linear plasmid | DNA-directed DNA polymerase, family B, mitochondrial linear plasmid | DNA-dir_DNA_pol_B_mt_lin_plsmd | 6 |
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