LiteFold/InterPro · Datasets at Hugging Face

IPR017717

17,717

2,3-diketo-5-methylthiopentyl-1-phosphate enolase

Diketo-Methiopentyl-P_enolase

Family

997

false

Members of this family are the methionine salvage pathway enzyme 2,3-diketo-5-methylthiopentyl-1-phosphate enolase, a homologue of RuBisCO [ , ]. They catalyze the tautomerization of 2,3-diketo-5-methylthiopentane 1-phosphate (DK-MTP 1-P). This is an important step in the methionine salvage pathway in which 5-methylthi...

[ "GO:0000287", "GO:0043715", "GO:0019509" ]

[ "magnesium ion binding", "2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity", "L-methionine salvage from methylthioadenosine" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "SFLD", "NCBIFAM", "CDD" ]

[ "MF_01679", "SFLDF00157", "TIGR03332", "cd08209" ]

[ "Salvage_MtnW", "2_3-diketo-5-methylthiopentyl-", "salvage_mtnW", "RLP_DK-MTP-1-P-enolase" ]

[ 624, 969, 879, 812 ]

4

[ "EC", "GP", "METACYC" ]

[ "5.3.2.5", "GenProp0732", "PWY-4361" ]

[ "EC:5.3.2.5", "GP:GenProp0732", "METACYC:PWY-4361" ]

3

[ "2oej", "2oek", "2oel", "2oem", "2zvi", "3fk4", "4nas" ]

7

[ "PUB00016716", "PUB00080676" ]

[ "14551435", "19279009" ]

[ "A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.", "Structural and functional similarities between a ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO)-like protein from Bacillus subtilis and photosynthetic RuBisCO." ]

[ 2003, 2009 ]

2

[ "IPR033966" ]

[]

1

0

1

[ "Bacteria" ]

[ 997 ]

1

[]

0

true

Family

2,3-diketo-5-methylthiopentyl-1-phosphate enolase

Diketo-Methiopentyl-P_enolase

1

IPR017718

17,718

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase

HAD-SF_hydro_IB_MtnX

Family

983

false

This entry represents 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase, MtnX, which is involved in methionine salvage and belongs to the HAD-superfamily hydrolases, subfamily IB [ ]. This enzyme is found in Bacillus subtilis and related species, paired with MtnW ( ). In most species that recycle methionine...

[ "GO:0016791", "GO:0071267" ]

[ "phosphatase activity", "L-methionine salvage" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01680", "TIGR03333" ]

[ "Salvage_MtnX", "salvage_mtnX" ]

[ 983, 541 ]

2

[ "EC", "GP", "METACYC" ]

[ "3.1.3.87", "GenProp0732", "PWY-4361" ]

[ "EC:3.1.3.87", "GP:GenProp0732", "METACYC:PWY-4361" ]

3

[ "2fea" ]

1

[ "PUB00047443" ]

[ "17654724" ]

[ "Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 angstroms resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate." ]

[ 2007 ]

1

[ "IPR006384" ]

[]

1

0

1

[ "Bacteria" ]

[ 983 ]

1

[]

0

true

Family

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase

HAD-SF_hydro_IB_MtnX

1

IPR017719

17,719

Indolepyruvate ferredoxin oxidoreductase, beta subunit

Indolepyruvate_Fd_OxRdtase_bsu

Family

247

false

This entry represents the beta subunit of indolepyruvate ferredoxin oxidoreductase (IOR; ), an α(2)/β(2) tetramer whose cofactors include TPP, 4Fe4S, and 3Fe-4S. This enzyme is related to several other ketoacid oxidoreductases, including: the ketoacid oxidoreductases for pyruvate ( , POR), 2-ketoglutarate ( , KOR), and...

[ "GO:0043805" ]

[ "indolepyruvate ferredoxin oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03334" ]

[ "IOR_beta" ]

[ 247 ]

1

[ "EC" ]

[ "1.2.7.8" ]

[ "EC:1.2.7.8" ]

1

[]

0

[ "PUB00043088", "PUB00044664" ]

[ "15262931", "9180697" ]

[ "Two biosynthetic pathways for aromatic amino acids in the archaeon Methanococcus maripaludis.", "Indolepyruvate ferredoxin oxidoreductase from Pyrococcus sp. KOD1 possesses a mosaic structure showing features of various oxidoreductases." ]

[ 2004, 1997 ]

2

[ "IPR052198" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 208, 30, 9 ]

3

[]

0

true

Family

Indolepyruvate ferredoxin oxidoreductase, beta subunit

Indolepyruvate_Fd_OxRdtase_bsu

6

IPR017720

17,720

Coenzyme F390 synthetase

Coenzyme_F390_Synthase

Family

122

false

This enzyme, characterised in Methanobacterium thermoautotrophicum and found in several other methanogens, modifies coenzyme F420 by ligation of AMP (or GMP) from ATP (or GTP). On F420, it activates an aromatic hydroxyl group, which is unusual chemistry for an adenylyltransferase. This enzyme name has also been attache...

[]

0

[ "NCBIFAM" ]

[ "TIGR03335" ]

[ "F390_ftsA" ]

[ 122 ]

1

[]

0

[]

0

[ "PUB00093687" ]

[ "8536708" ]

[ "Purification and properties of coenzyme F390 hydrolase from Methanobacterium thermoautotrophicum (strain Marburg)." ]

[ 1995 ]

1

[]

0

null

[ "Methanobacteriota", "ecological metagenomes" ]

[ 118, 4 ]

2

[]

0

true

Family

Coenzyme F390 synthetase

Coenzyme_F390_Synthase

9

IPR017721

17,721

Indolepyruvate oxidoreductase subunit IorA

IorA

Family

3,383

false

This entry represents the alpha subunit of indolepyruvate ferredoxin oxidoreductase (IOR; ), an α(2)/β(2) tetramer whose cofactors include TPP, 4Fe4S, and 3Fe-4S. This enzyme is related to several other ketoacid oxidoreductases, including the ketoacid oxidoreductases for pyruvate ( , POR), 2-ketoglutarate ( , KOR), and...

[ "GO:0043805" ]

[ "indolepyruvate ferredoxin oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF006439", "TIGR03336" ]

[ "Indolepyruvate_ferr_oxidored", "IOR_alpha" ]

[ 3377, 1908 ]

2

[ "EC" ]

[ "1.2.7.8" ]

[ "EC:1.2.7.8" ]

1

[]

0

[ "PUB00043088", "PUB00044664" ]

[ "15262931", "9180697" ]

[ "Two biosynthetic pathways for aromatic amino acids in the archaeon Methanococcus maripaludis.", "Indolepyruvate ferredoxin oxidoreductase from Pyrococcus sp. KOD1 possesses a mosaic structure showing features of various oxidoreductases." ]

[ 2004, 1997 ]

2

[ "IPR045025" ]

[]

1

0

1

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 642, 2667, 74 ]

3

[]

0

true

Family

Indolepyruvate oxidoreductase subunit IorA

IorA

6

IPR017722

17,722

Phosphonate utilization transcriptional regulator PhnR

Tscrpt_reg_PhnR

Family

818

false

This entry represents proteins which are members of the wider GntR family ( ), containing an N-terminal helix-turn-helix (HTH) motif. These proteins are found adjacent to, or inside of, operons for the degradation of 2-aminoethylphosphonate (AEP) in Salmonella, Vibrio, Aeromonas hydrophila, Hahella chejuensis and Psych...

[]

0

[ "NCBIFAM" ]

[ "TIGR03337" ]

[ "phnR" ]

[ 818 ]

1

[ "GP" ]

[ "GenProp0720" ]

[ "GP:GenProp0720" ]

1

[]

0

[ "PUB00042844" ]

[ "7592415" ]

[ "Molecular cloning, mapping, and regulation of Pho regulon genes for phosphonate breakdown by the phosphonatase pathway of Salmonella typhimurium LT2." ]

[ 1995 ]

1

[]

0

null

[ "Bacteria", "Thelohanellus kitauei" ]

[ 817, 1 ]

2

[]

0

true

Family

Phosphonate utilization transcriptional regulator PhnR

Tscrpt_reg_PhnR

4

IPR017724

17,724

Aminoethylphosphonate utilisation-associated transcription regulator, LysR-type

Tscrpt_reg_LysR

Family

1,659

false

This group of sequences represents a number of related clades with numerous examples of members adjacent to operons for the degradation of 2-aminoethylphosphonate (AEP) in Pseudomonas, Ralstonia, Bordetella and Burkholderia species. These are transcriptional regulators of the LysR family which contain a helix-turn-heli...

[]

0

[ "NCBIFAM" ]

[ "TIGR03339" ]

[ "phn_lysR" ]

[ 1659 ]

1

[ "GP" ]

[ "GenProp0720" ]

[ "GP:GenProp0720" ]

1

[]

0

[]

0

[]

0

null

[ "Anopheles melas", "Bacteria", "uncultured soil microorganism" ]

[ 1, 1655, 3 ]

3

[]

0

true

Family

Aminoethylphosphonate utilisation-associated transcription regulator, LysR-type

Tscrpt_reg_LysR

8

IPR017725

17,725

Phosphonate utilization associated transmembrane protein, putative

Phosphonate_util-assoc_TM_put

Family

156

false

Proteins in this entry appear to have transmembrane domains and may function as permeases. They are encoded in the vicinity of various types of operons for the catabolism of phosphonates in Vibrio, Pseudomonas, Polaromonas and Thiomicrospira.

[]

0

[ "NCBIFAM" ]

[ "TIGR03340" ]

[ "phn_DUF6" ]

[ 156 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadota" ]

[ 156 ]

1

[]

0

true

Family

Phosphonate utilization associated transmembrane protein, putative

Phosphonate_util-assoc_TM_put

2

IPR017726

17,726

Fe/S biogenesis protein NfuA

Fe/S_biogenesis_protein_NfuA

Family

4,028

false

This entry represents Fe/S biogenesis protein NfuA from gammaproteobacteria. This protein is involved in iron-sulphur cluster biogenesis under severe conditions such as iron starvation or oxidative stress. It binds a 4Fe-4S cluster and can transfer this cluster to apoproteins, thereby intervening in the maturation of F...

[ "GO:0051539", "GO:0016226", "GO:0051604" ]

[ "4 iron, 4 sulfur cluster binding", "iron-sulfur cluster assembly", "protein maturation" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01637", "TIGR03341" ]

[ "Fe_S_biogen_NfuA", "YhgI_GntY" ]

[ 4028, 3495 ]

2

[]

0

[]

0

[ "PUB00033882", "PUB00043090", "PUB00106736", "PUB00106880" ]

[ "9871335", "16677314", "18339628", "30092083" ]

[ "The gluconate high affinity transport of GntI in Escherichia coli involves a multicomponent complex system.", "IscR-dependent gene expression links iron-sulphur cluster assembly to the control of O2-regulated genes in Escherichia coli.", "NfuA, a new factor required for maturing Fe/S proteins in Escherichia co...

[ 1998, 2006, 2008, 2018 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3997, 5, 26 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Fe/S biogenesis protein NfuA

Fe/S_biogenesis_protein_NfuA

4

IPR017730

17,730

Chaperonin ClpB

Chaperonin_ClpB

Family

22,739

false

Members of this protein family include bacterial and plant ATP-dependent chaperone ClpB. This protein belongs to the AAA family of ATPases associated with various cellular activities. This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins [ , , ].

[ "GO:0009408", "GO:0042026", "GO:0005737" ]

[ "response to heat", "protein refolding", "cytoplasm" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR03346" ]

[ "chaperone_ClpB" ]

[ 22739 ]

1

[]

0

[ "1qvr", "4ciu", "4d2q", "4d2u", "4d2x", "5ofo", "5og1", "6dju", "6djv", "6ed3", "6oax", "6oay", "6og1", "6og2", "6og3", "6qs4", "6qs6", "6qs7", "6qs8", "6rn2", "6rn3", "6rn4", "6w6e", "6w6g", "6w6h", "6w6i", "6w6j", "7l6n" ]

28

[ "PUB00043091", "PUB00088088", "PUB00103736" ]

[ "15037241", "28824920", "32803477" ]

[ "The ClpB/Hsp104 molecular chaperone-a protein disaggregating machine.", "Comparative Analysis of the Structure and Function of AAA+ Motors ClpA, ClpB, and Hsp104: Common Threads and Disparate Functions.", "Biochemical characterization of ClpB3, a chloroplastic disaggregase from Arabidopsis thaliana." ]

[ 2004, 2017, 2020 ]

3

[ "IPR001270" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 45, 21378, 1160, 1, 155 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 1, 4, 6 ]

4

true

Family

Chaperonin ClpB

Chaperonin_ClpB

3

IPR017731

17,731

Type VI secretion system protein TssM1-like

TssM1-like

Family

6,811

false

This entry includes TssM1, which is a component of the bacterial type VI secretion system (T6SS) [ ]. The type VI secretion system (T6SS), also known as CIS contractile injection system [ ], is a supra-molecular bacterial complex that resembles phage tails. It is a toxin delivery systems which fires toxins into target ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03348" ]

[ "VI_IcmF" ]

[ 6811 ]

1

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[]

0

[ "PUB00093972", "PUB00093973", "PUB00160456" ]

[ "27288401", "31379775", "39546591" ]

[ "TssA forms a gp6-like ring attached to the type VI secretion sheath.", "Baseplate Component TssK and Spatio-Temporal Assembly of T6SS in Pseudomonas aeruginosa.", "Archaeal type six secretion system mediates contact-dependent antagonism." ]

[ 2016, 2019, 2024 ]

3

[]

0

null

[ "Bacteria", "Rhabditidae", "unclassified sequences" ]

[ 6764, 2, 45 ]

3

[]

0

true

Family

Type VI secretion system protein TssM1-like

TssM1-like

3

IPR017732

17,732

Type IV / VI secretion system, DotU

T4/T6SS_DotU

Domain

8,652

false

At least two distinct groups of proteins, often encoded by adjacent genes, show sequence similarity due to homology between type IV secretion systems and type VI secretion systems. One is the IcmF family ( ). The other group is the DotU family, which includes DotU from the Legionella pneumophila type IV secretion syste...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09850", "TIGR03349" ]

[ "DotU", "IV_VI_DotU" ]

[ 8650, 7932 ]

2

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[ "3u66", "4ack", "4acl", "4v3i", "6y4r", "7thw" ]

6

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8596, 12, 44 ]

3

[]

0

true

Domain

Type IV / VI secretion system, DotU

T4/T6SS_DotU

1

IPR017733

17,733

Type VI secretion system, OmpA-like domain, proteobacteria

OmpA-like_dom_proteobacteria

Domain

2,506

false

This entry represents a domain found at the C-terminal end of long forms of TssL, a component of type VI secretion systems (T6SS) [ , ], although other forms of TssL lack this domain. The domain shares homology with peptidoglycan-associating C-terminal regions of the Gram-negative bacterial outer membrane protein OmpA,...

[]

0

[ "NCBIFAM" ]

[ "TIGR03350" ]

[ "type_VI_ompA" ]

[ 2506 ]

1

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[ "4b62" ]

1

[ "PUB00034462", "PUB00106737", "PUB00106883" ]

[ "16763151", "22371492", "22950014" ]

[ "A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.", "Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems.", "The C-tail anchored TssL subunit, an essential protein of the enteroaggregative E...

[ 2006, 2012, 2012 ]

3

[ "IPR006665" ]

[]

1

0

1

[ "Pseudomonadota", "Rhabditida", "unclassified sequences" ]

[ 2487, 2, 17 ]

3

[]

0

true

Domain

Type VI secretion system, OmpA-like domain, proteobacteria

OmpA-like_dom_proteobacteria

7

IPR017734

17,734

Type VI secretion system, lipoprotein SciN

T6SS_SciN

Family

6,458

false

One of the virulence mechanisms of Escherichia coli is the production of toxins from dedicated machineries called secretion systems. Seven secretion systems have been described, which assemble from 3 to up-to more than 20 subunits. These secretion systems derive from or have co-evolved with bacterial organelles such as...

[]

0

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF12790", "PTHR37625", "TIGR03352" ]

[ "T6SS-SciN", "", "VI_chp_3" ]

[ 6451, 6106, 6288 ]

3

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[ "3rx9", "3zhn", "4a1r", "4y7o", "6hs7", "6ixh" ]

6

[ "PUB00067798", "PUB00067835" ]

[ "15385502", "18805985" ]

[ "Legionella pneumophila DotU and IcmF are required for stability of the Dot/Icm complex.", "SciN is an outer membrane lipoprotein required for type VI secretion in enteroaggregative Escherichia coli." ]

[ 2004, 2008 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6407, 8, 43 ]

3

[]

0

true

Family

Type VI secretion system, lipoprotein SciN

T6SS_SciN

2

IPR017735

17,735

Type VI secretion system, FHA domain-containing protein

T6SS_FHA

Family

3,599

false

Members of this protein family are FHA (forkhead-associated) domain-containing proteins that are part of type VI secretion loci in a considerable number of bacteria, most of which are known pathogens. Species include Pseudomonas aeruginosa PAO1, Aeromonas hydrophila, Yersinia pestis and Burkholderia mallei [ , ].

[]

0

[ "NCBIFAM" ]

[ "TIGR03354" ]

[ "VI_FHA" ]

[ 3599 ]

1

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[]

0

[ "PUB00034462", "PUB00105085" ]

[ "16763151", "17660433" ]

[ "A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.", "In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages." ]

[ 2006, 2007 ]

2

[]

0

null

[ "Bacteria", "Rhabditida", "metagenomes" ]

[ 3572, 2, 25 ]

3

[]

0

true

Family

Type VI secretion system, FHA domain-containing protein

T6SS_FHA

5

IPR017737

17,737

Type VI secretion system protein TssE1-like

TssE1-like

Family

6,849

false

This entry includes TssE1, which is a baseplate component of the bacterial type VI secretion system (T6SS). It shares structural homology with T4 inner baseplate protein gp25 [ ]. The type VI secretion system (T6SS), also known as CIS contractile injection system [ ], is a supra-molecular bacterial complex that resembl...

[]

0

[ "NCBIFAM" ]

[ "TIGR03357" ]

[ "VI_zyme" ]

[ 6849 ]

1

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[ "6gj1" ]

1

[ "PUB00093972", "PUB00093973", "PUB00093974", "PUB00160456" ]

[ "27288401", "31379775", "29255010", "39546591" ]

[ "TssA forms a gp6-like ring attached to the type VI secretion sheath.", "Baseplate Component TssK and Spatio-Temporal Assembly of T6SS in Pseudomonas aeruginosa.", "Cryo-EM reconstruction of Type VI secretion system baseplate and sheath distal end.", "Archaeal type six secretion system mediates contact-depend...

[ 2016, 2019, 2018, 2024 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6805, 6, 38 ]

3

[]

0

true

Family

Type VI secretion system protein TssE1-like

TssE1-like

6

IPR017738

17,738

Type VI secretion system-associated, VCA0118

T6SS-assoc_VCA0118

Family

1,304

false

Proteins in this entry, including VC_A0118 from Vibrio cholerae O1 biovar eltor str. N16961, are restricted to a subset of bacteria with the type VI secretion system, and are encoded among the type VI-associated pathogenicity islands. However, many species with type VI secretion lack a member of this family, suggesting...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF11319", "TIGR03360" ]

[ "VasI", "VI_minor_1" ]

[ 1304, 920 ]

2

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Xuanwuvirus P884B11", "metagenomes" ]

[ 1298, 1, 5 ]

3

[]

0

true

Family

Type VI secretion system-associated, VCA0118

T6SS-assoc_VCA0118

8

IPR017739

17,739

Type VI secretion system-associated, VCA0119

T6SS-assoc_VCA0119

Family

3,216

false

This entry represents one of two related families in type VI secretion systems that contain an ImpA-related N-terminal domain ( ). This group includes VCA0119 from Vibrio alginolyticus [ ].

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF16989", "TIGR03362" ]

[ "T6SS_VasJ", "VI_chp_7" ]

[ 3216, 2824 ]

2

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[ "4yo3", "4yo5", "6g7b", "6g7c", "6riu", "6rju" ]

6

[ "PUB00067834" ]

[ "23021863" ]

[ "Connecting type VI secretion, quorum sensing, and c-di-GMP production in fish pathogen Vibrio alginolyticus through phosphatase PppA." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3199, 3, 14 ]

3

[]

0

true

Family

Type VI secretion system-associated, VCA0119

T6SS-assoc_VCA0119

7

IPR017740

17,740

Type VI secretion system protein TssA-like

TssA-like

Family

5,055

false

This entry represents one of two related families in type VI secretion systems (T6SS) that contain an ImpA-related N-terminal domain ( ). This group includes Rhizobium leguminosarum ImpA [ ], thought to be an T6SS homologue [ ]. This entry also includes TssA, which is a T6SS component forming dodecameric ring structure...

[]

0

[ "PANTHER", "NCBIFAM" ]

[ "PTHR37951", "TIGR03363" ]

[ "", "VI_chp_8" ]

[ 5045, 3633 ]

2

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[ "6h8e", "6h8f", "6hs5", "6hs6" ]

4

[ "PUB00011186", "PUB00067801", "PUB00093972", "PUB00093973", "PUB00160456" ]

[ "12580282", "19284603", "27288401", "31379775", "39546591" ]

[ "Infection-blocking genes of a symbiotic Rhizobium leguminosarum strain that are involved in temperature-dependent protein secretion.", "Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources?", "TssA forms a gp6-like...

[ 2003, 2009, 2016, 2019, 2024 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5018, 6, 31 ]

3

[]

0

true

Family

Type VI secretion system protein TssA-like

TssA-like

2

IPR017741

17,741

FAD-dependent oxidoreductase, HpnW

FAD-dependent_OxRdtase_HpnW

Family

3,045

false

This entry represents a clade of FAD-dependent oxidoreductases syntenically associated with a family of proposed phosphonatase-like enzymes ( ) and is also found (less frequently) in association with phosphonate transporter components. A likely role for this enzyme involves the oxidative deamination of an aminophosphon...

[]

0

[ "NCBIFAM" ]

[ "TIGR03364" ]

[ "HpnW_proposed" ]

[ 3045 ]

1

[ "GP", "GP" ]

[ "GenProp0241", "GenProp0736" ]

[ "GP:GenProp0241", "GP:GenProp0736" ]

2

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 3036, 6, 3 ]

3

[]

0

true

Family

FAD-dependent oxidoreductase, HpnW

FAD-dependent_OxRdtase_HpnW

4

IPR017742

17,742

7-carboxy-7-deazaguanine synthase

Deazaguanine_synth

Family

2,196

false

7-deazapurines are compounds that contain pyrrolopyrimidine functional groups (similar to purines, but lacking one of the nitrogens in the pentameric ring). These compounds form a structurally diverse class of nucleoside analogues that often possess antibiotic, antineoplastic, or antiviral activities. Examples of 7-dea...

[]

0

[ "SFLD", "NCBIFAM" ]

[ "SFLDF00300", "TIGR03365" ]

[ "7-carboxy-7-deazaguanine_synth", "Bsubt_queE" ]

[ 1470, 2196 ]

2

[ "EC", "GP", "METACYC" ]

[ "4.3.99.3", "GenProp1602", "PWY-6703" ]

[ "EC:4.3.99.3", "GP:GenProp1602", "METACYC:PWY-6703" ]

3

[ "5tgs", "5th5" ]

2

[ "PUB00035932", "PUB00056816" ]

[ "14660578", "19354300" ]

[ "Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine.", "The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps." ]

[ 2004, 2009 ]

2

[ "IPR024924" ]

[]

1

0

1

[ "Bacteria", "Phytophthora kernoviae 00238/432", "Siphoviridae sp. ctaDn21", "ecological metagenomes" ]

[ 2186, 1, 1, 8 ]

4

[]

0

true

Family

7-carboxy-7-deazaguanine synthase

Deazaguanine_synth

6

IPR017743

17,743

Alcohol dehydrogenase, phosphonate catabolism-associated, putative

ADH_phosphonate_catab-assoc

Family

461

false

This entry represents a clade of zinc-binding alcohol dehydrogenases that are repeatedly associated with genes proposed to be involved with the catabolism of phosphonate compounds.

[]

0

[ "NCBIFAM" ]

[ "TIGR03366" ]

[ "HpnZ_proposed" ]

[ 461 ]

1

[ "GP" ]

[ "GenProp0736" ]

[ "GP:GenProp0736" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Symbiodiniaceae", "ecological metagenomes" ]

[ 455, 3, 3 ]

3

[]

0

true

Family

Alcohol dehydrogenase, phosphonate catabolism-associated, putative

ADH_phosphonate_catab-assoc

3

IPR017744

17,744

Cellulose biosynthesis protein BcsG

BcsG

Family

2,050

false

Cellulose biosynthesis protein BcsG, also known as YhjU, is a component of bacterial cellulose synthase complex that plays a role in biofilm formation in bacteria [ , , ]. It is a Zn-dependent phosphoethanolamine transferase that catalyses transfer of phosphoethanolamine residues from membrane phosphatidylethanolamine ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF11658", "TIGR03368" ]

[ "CBP_BcsG", "cellulose_yhjU" ]

[ 2050, 1886 ]

2

[ "GP", "REACTOME" ]

[ "GenProp0658", "R-HSA-9931953" ]

[ "GP:GenProp0658", "REACTOME:R-HSA-9931953" ]

2

[ "5ojh", "5olt", "6pcz", "6pd0", "9b8v", "9fmv", "9fmz", "9fnn", "9fp0" ]

9

[ "PUB00034422", "PUB00042856", "PUB00075887", "PUB00100650", "PUB00100651", "PUB00100652", "PUB00100653" ]

[ "16930487", "11929533", "26077867", "29348238", "29348224", "30017920", "32152228" ]

[ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.", "Genetic analysis of Salmonella enteritidis biofilm formation: critical role of cellulose.", "Bacterial cellulose biosynthesis: diversity of operons, su...

[ 2006, 2002, 2015, 2018, 2018, 2018, 2020 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2035, 6, 9 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Cellulose biosynthesis protein BcsG

BcsG

1

IPR017745

17,745

Cellulose biosynthesis protein BcsE

BcsE

Family

1,973

false

BcsE (bacterial cellulose synthase E) or YhjS, is required for cellulose biosynthesis in Salmonella enteritidis. Its role is this process across multiple bacterial species is implied by the partial phylogenetic profiling algorithm. Members are found in the vicinity of other cellulose biosynthesis genes [ , ]. BcsE cont...

[ "GO:0035438" ]

[ "cyclic-di-GMP binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "PFAM", "NCBIFAM" ]

[ "NF011619", "PF10995", "TIGR03369" ]

[ "PRK15045.1", "CBP_BcsE", "cellulose_bcsE" ]

[ 837, 1973, 1687 ]

3

[ "GP", "REACTOME" ]

[ "GenProp0658", "R-HSA-9931953" ]

[ "GP:GenProp0658", "REACTOME:R-HSA-9931953" ]

2

[ "6tj0", "6ybb", "6ybu", "9fnn", "9fo7", "9fp0", "9fp2" ]

7

[ "PUB00042856", "PUB00075887", "PUB00086880", "PUB00100648", "PUB00100649", "PUB00100650" ]

[ "11929533", "26077867", "24942809", "33712813", "32788377", "29348238" ]

[ "Genetic analysis of Salmonella enteritidis biofilm formation: critical role of cellulose.", "Bacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions.", "GIL, a new c-di-GMP-binding protein domain involved in regulation of cellulose synthesis in enterobacteria.", "Molecular o...

[ 2002, 2015, 2014, 2021, 2020, 2018 ]

6

[]

0

null

[ "Fungi", "Pseudomonadota", "metagenomes" ]

[ 3, 1962, 8 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Cellulose biosynthesis protein BcsE

BcsE

6

IPR017746

17,746

Cellulose synthase operon protein BcsQ

Cellulose_synthase_operon_BcsQ

Family

3,721

false

The BcsQ (also known as YhjQ) protein is encoded immediately upstream of bacterial cellulose synthase (bcs) genes in a broad range of bacteria, including both copies of the bcs locus in Klebsiella pneumoniae, and in several species is clearly part of the bcs operon. It is identified as a probable component of the bacte...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF06564", "TIGR03371" ]

[ "CBP_BcsQ", "cellulose_yhjQ" ]

[ 3721, 2542 ]

2

[ "GP", "REACTOME" ]

[ "GenProp0658", "R-HSA-9931953" ]

[ "GP:GenProp0658", "REACTOME:R-HSA-9931953" ]

2

[ "6yar", "6yay", "6yb3", "6yb5", "6ybb", "6ybu", "9fnn", "9fp0", "9fp2" ]

9

[ "PUB00034422", "PUB00075451" ]

[ "16930487", "19400787" ]

[ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.", "BcsQ is an essential component of the Escherichia coli cellulose biosynthesis apparatus that localizes at the bacterial cell pole." ]

[ 2006, 2009 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Halomicrobium zhouii", "unclassified sequences" ]

[ 3681, 5, 1, 34 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Cellulose synthase operon protein BcsQ

Cellulose_synthase_operon_BcsQ

6

IPR017747

17,747

Putrescine aminotransferase

Putrescine_aminotransferase

Family

1,285

false

This entry represents putrescine aminotransferase ( ) as found in Escherichia coli [ ], Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum), and closely related species. Putrescine aminotransferase catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-amin...

[ "GO:0030170", "GO:0033094", "GO:0009447" ]

[ "pyridoxal phosphate binding", "putrescine--2-oxoglutarate transaminase activity", "putrescine catabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01276", "TIGR03372" ]

[ "Putres_aminotrans_3", "putres_am_tran" ]

[ 1159, 1282 ]

2

[ "EC", "EC", "GP", "GP", "METACYC" ]

[ "2.6.1.29", "2.6.1.82", "GenProp1279", "GenProp1362", "PWY-6328" ]

[ "EC:2.6.1.29", "EC:2.6.1.82", "GP:GenProp1279", "GP:GenProp1362", "METACYC:PWY-6328" ]

5

[ "4uox", "4uoy", "5h7d", "5x3f", "8cpl", "8r2p" ]

6

[ "PUB00044715" ]

[ "3510672" ]

[ "A pathway for putrescine catabolism in Escherichia coli." ]

[ 1986 ]

1

[ "IPR005814" ]

[]

1

0

1

[ "Bacteria", "Trichuris trichiura" ]

[ 1284, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Putrescine aminotransferase

Putrescine_aminotransferase

7

IPR017748

17,748

T6S-associated protein TagF

TagF

Family

3,765

false

This entry includes the T6S-associated protein, TagF, a post-translational repressor of the hemolysin co-regulated secretion island I (HSI-I)-encoded type VI secretion system (H1-T6SS), found in Pseudomonas aeruginosa. The type VI secretion system (T6SS) is found broadly among the Proteobacteria and is implicated in di...

[]

0

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF09867", "PIRSF029287", "TIGR03373" ]

[ "TagF_N", "UCP029287", "VI_minor_4" ]

[ 3764, 1491, 3261 ]

3

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[ "2qnu", "6iz8", "9t0n" ]

3

[ "PUB00086563" ]

[ "22017253" ]

[ "Separate inputs modulate phosphorylation-dependent and -independent type VI secretion activation." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3729, 2, 34 ]

3

[]

0

true

Family

T6S-associated protein TagF

TagF

3

IPR017749

17,749

Gamma-aminobutyraldehyde dehydrogenase

PatD

Family

1,293

false

This entry represents gamma-aminobutyraldehyde dehydrogenase (PatD, ) involved in the second step in one of two pathways for putrescine degradation. It catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA) [ , ]. It also functions as a 5-aminopentanal dehydr...

[ "GO:0019145", "GO:0051287", "GO:0009447" ]

[ "aminobutyraldehyde dehydrogenase (NAD+) activity", "NAD binding", "putrescine catabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01275", "TIGR03374" ]

[ "Aldedh_Prr", "ABALDH" ]

[ 1268, 1232 ]

2

[ "EC", "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", ...

[ "1.2.1.-", "1.2.1.19", "GenProp1279", "GenProp1362", "PWY-1121", "PWY-2", "PWY-2724", "PWY-282", "PWY-3", "PWY-3162", "PWY-321", "PWY-5168", "PWY-5305", "PWY-5875", "PWY-5885", "PWY-6309", "PWY-6322", "PWY-6328", "PWY-6681", "PWY-6713", "PWY-6832", "PWY-6863", "PWY-6926",...

[ "EC:1.2.1.-", "EC:1.2.1.19", "GP:GenProp1279", "GP:GenProp1362", "METACYC:PWY-1121", "METACYC:PWY-2", "METACYC:PWY-2724", "METACYC:PWY-282", "METACYC:PWY-3", "METACYC:PWY-3162", "METACYC:PWY-321", "METACYC:PWY-5168", "METACYC:PWY-5305", "METACYC:PWY-5875", "METACYC:PWY-5885", "METACYC:...

36

[ "1wnb", "1wnd", "6c43" ]

3

[ "PUB00032275", "PUB00042939", "PUB00044715", "PUB00092438" ]

[ "15381418", "16023116", "3510672", "30498244" ]

[ "Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase.", "Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase.", "A pathway for putrescine catabolism in Escherichia coli.", "Widespread bacterial lysine d...

[ 2004, 2005, 1986, 2018 ]

4

[ "IPR015657" ]

[]

1

0

1

[ "Beauveria bassiana D1-5", "Pseudomonadota" ]

[ 1, 1292 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Gamma-aminobutyraldehyde dehydrogenase

PatD

8

IPR017750

17,750

ATPase, type I secretion system

ATPase_T1SS

Family

5,849

false

Type I protein secretion is a system in some Gram-negative bacteria to export proteins (often proteases) across both inner and outer membranes to the extracellular medium. This is one of three proteins of the type I secretion apparatus. Targeted proteins are not cleaved at the N terminus, but rather carry signals locat...

[]

0

[ "NCBIFAM" ]

[ "TIGR03375" ]

[ "type_I_sec_LssB" ]

[ 5849 ]

1

[ "GP" ]

[ "GenProp0059" ]

[ "GP:GenProp0059" ]

1

[]

0

[]

0

[ "IPR039421" ]

[]

1

0

1

[ "Bacteria", "Candidatus Nitrosopumilus salarius BD31", "Eukaryota", "metagenomes" ]

[ 5819, 1, 7, 22 ]

4

[]

0

true

Family

ATPase, type I secretion system

ATPase_T1SS

9

IPR017751

17,751

Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic

G3P_DH_NAD-dep_euk

Family

6,374

false

This entry represents eukaryotic glycerol-3-phosphate dehydrogenase ( ). The reaction catalysed by this enzyme is: sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH Note that similar, though distinct, reactions ( and ), occur in the bacterial proteins.

[ "GO:0042803", "GO:0051287", "GO:0006072" ]

[ "protein homodimerization activity", "NAD binding", "glycerol-3-phosphate metabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR03376" ]

[ "glycerol3P_DH" ]

[ 6374 ]

1

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.1.1.8", "GenProp1316", "GenProp1750", "PWY-6118", "PWY-7385", "PWY-7411", "R-CEL-1483166", "R-DME-1483166", "R-DRE-1483166", "R-HSA-1483166", "R-MMU-1483166", "R-RNO-1483166", "R-SCE-1483166", "R-SPO-1483166", "R-XTR-1483166" ]

[ "EC:1.1.1.8", "GP:GenProp1316", "GP:GenProp1750", "METACYC:PWY-6118", "METACYC:PWY-7385", "METACYC:PWY-7411", "REACTOME:R-CEL-1483166", "REACTOME:R-DME-1483166", "REACTOME:R-DRE-1483166", "REACTOME:R-HSA-1483166", "REACTOME:R-MMU-1483166", "REACTOME:R-RNO-1483166", "REACTOME:R-SCE-1483166", ...

15

[ "1wpq", "1x0v", "1x0x", "1yj8", "2pla", "4fgw", "6e8y", "6e8z", "6e90", "6iuy", "6pyp" ]

11

[]

0

[ "IPR006168" ]

[]

1

0

1

[ "Bacteria", "Eukaryota" ]

[ 2, 6372 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 5, 6, 13, 4, 4, 1, 2, 8, 2, 2, 5 ]

12

true

Family

Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic

G3P_DH_NAD-dep_euk

4

IPR017752

17,752

Glycerol-3-phosphate dehydrogenase, GlpA subunit

G3P_DH_GlpA_su

Family

2,342

false

This entry represents the GlpA subunit. An archaeal homologue has also recently been characterised [ ], which appears to be used under aerobic conditions in halophilic archaea. In bacteria, glycerol uptake is mediated by the glycerol diffusion facilitator, an integral membrane protein catalysing the rapid equilibration...

[ "GO:0004368", "GO:0010181", "GO:0050660", "GO:0046174", "GO:0005886", "GO:0009331" ]

[ "glycerol-3-phosphate dehydrogenase (quinone) activity", "FMN binding", "flavin adenine dinucleotide binding", "polyol catabolic process", "plasma membrane", "glycerol-3-phosphate dehydrogenase (FAD) complex" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

6

[ "NCBIFAM" ]

[ "TIGR03377" ]

[ "glycerol3P_GlpA" ]

[ 2342 ]

1

[ "EC", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC" ]

[ "1.1.5.3", "GenProp0737", "GenProp1391", "GenProp1676", "GenProp1729", "PWY-4261", "PWY-6118", "PWY-6952" ]

[ "EC:1.1.5.3", "GP:GenProp0737", "GP:GenProp1391", "GP:GenProp1676", "GP:GenProp1729", "METACYC:PWY-4261", "METACYC:PWY-6118", "METACYC:PWY-6952" ]

8

[]

0

[ "PUB00012960", "PUB00059145", "PUB00059152" ]

[ "7576488", "21725010", "6792201" ]

[ "Physiological role of GlpB of anaerobic glycerol-3-phosphate dehydrogenase of Escherichia coli.", "Activity and transcriptional regulation of bacterial protein-like glycerol-3-phosphate dehydrogenase of the haloarchaea in Haloferax volcanii.", "The anaerobic sn-glycerol-3-phosphate dehydrogenase of Escherichia...

[ 1995, 2011, 1981 ]

3

[ "IPR000447" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Halobacteriales", "metagenomes" ]

[ 2018, 3, 315, 6 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glycerol-3-phosphate dehydrogenase, GlpA subunit

G3P_DH_GlpA_su

3

IPR017753

17,753

Glycerol-3-phosphate dehydrogenase, GlpC subunit

G3P_DH_GlpC_su

Family

2,164

false

This entry represents the non-catalytic membrane-bound GlpC subunit. This protein lacks classical hydrophobic transmembrane helices; interaction with the membrane may involve amphipathic helices [ ]. GlcC has conserved Cys-containing motifs suggestive of iron-sulphur binding. An archaeal homologue has also recently bee...

[ "GO:0009061", "GO:0009331", "GO:0016020" ]

[ "anaerobic respiration", "glycerol-3-phosphate dehydrogenase (FAD) complex", "membrane" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR03379" ]

[ "glycerol3P_GlpC" ]

[ 2164 ]

1

[ "GP", "GP", "GP", "GP" ]

[ "GenProp0737", "GenProp1391", "GenProp1676", "GenProp1729" ]

[ "GP:GenProp0737", "GP:GenProp1391", "GP:GenProp1676", "GP:GenProp1729" ]

4

[]

0

[ "PUB00012960", "PUB00014572", "PUB00059145", "PUB00059152" ]

[ "7576488", "3286606", "21725010", "6792201" ]

[ "Physiological role of GlpB of anaerobic glycerol-3-phosphate dehydrogenase of Escherichia coli.", "Nucleotide sequence and gene-polypeptide relationships of the glpABC operon encoding the anaerobic sn-glycerol-3-phosphate dehydrogenase of Escherichia coli K-12.", "Activity and transcriptional regulation of bac...

[ 1995, 1988, 2011, 1981 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "metagenomes" ]

[ 1873, 2, 283, 6 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glycerol-3-phosphate dehydrogenase, GlpC subunit

G3P_DH_GlpC_su

4

IPR017754

17,754

Agmatine deiminase

Agmatine_deiminase

Family

4,288

false

Agmatine deiminase ( ) catalyses the conversion of agmatine into N-carbamoylputrescine. This enzyme usually functions as part of polyamine biosynthesis, though in some bacterial species, such as Enterococcus faecalis, it can also function in the generation of ATP from agmatine [ , , ]. The E. faecalis enzyme is a homot...

[ "GO:0047632", "GO:0009446" ]

[ "agmatine deiminase activity", "putrescine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01841", "TIGR03380" ]

[ "Agmatine_deimin", "agmatine_aguA" ]

[ 4176, 3554 ]

2

[ "EC", "GP", "GP", "GP", "METACYC" ]

[ "3.5.3.12", "GenProp0738", "GenProp1431", "GenProp1733", "PWY-43" ]

[ "EC:3.5.3.12", "GP:GenProp0738", "GP:GenProp1431", "GP:GenProp1733", "METACYC:PWY-43" ]

5

[ "1vkp", "2ewo", "2jer", "2q3u", "3h7c", "3h7k", "6nib", "6nic" ]

8

[ "PUB00041924", "PUB00043096", "PUB00043097", "PUB00043430" ]

[ "17028272", "12634339", "12782327", "6290446" ]

[ "The gene cluster for agmatine catabolism of Enterococcus faecalis: study of recombinant putrescine transcarbamylase and agmatine deiminase and a snapshot of agmatine deiminase catalyzing its reaction.", "Identification of the putrescine biosynthetic genes in Pseudomonas aeruginosa and characterization of agmatin...

[ 2007, 2003, 2003, 1982 ]

4

[ "IPR007466" ]

[]

1

0

1

[ "Bacteria", "Chlorovirus", "Eukaryota", "ecological metagenomes" ]

[ 3573, 6, 704, 5 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 3, 10 ]

3

true

Family

Agmatine deiminase

Agmatine_deiminase

7

IPR017755

17,755

N-carbamoylputrescine amidase

N-carbamoylputrescine_amidase

Family

3,426

false

This entry includes bacterial and plant members of the carbon-nitrogen hydrolase family, namely N-carbamoylputrescine amidase (NILP1/CPA) from Arabidopsis and citrullinase from Francisella tularensis subsp. tularensis. NILP1/CPA catalyses ( ) the hydrolysis of N-carbamoylputrescine to putrescine [ , ], the final step o...

[ "GO:0050126", "GO:0006596" ]

[ "N-carbamoylputrescine amidase activity", "polyamine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03381" ]

[ "agmatine_aguB" ]

[ 3426 ]

1

[ "EC", "GP", "GP", "GP", "METACYC" ]

[ "3.5.1.53", "GenProp0738", "GenProp1431", "GenProp1733", "PWY-43" ]

[ "EC:3.5.1.53", "GP:GenProp0738", "GP:GenProp1431", "GP:GenProp1733", "METACYC:PWY-43" ]

5

[ "5h8i", "5h8j", "5h8k", "5h8l" ]

4

[ "PUB00016860", "PUB00043096", "PUB00101145" ]

[ "12435743", "12634339", "19502406" ]

[ "Plant C-N hydrolases and the identification of a plant N-carbamoylputrescine amidohydrolase involved in polyamine biosynthesis.", "Identification of the putrescine biosynthetic genes in Pseudomonas aeruginosa and characterization of agmatine deiminase and N-carbamoylputrescine amidohydrolase of the arginine deca...

[ 2003, 2003, 2009 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2910, 482, 34 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 1, 2 ]

3

true

Family

N-carbamoylputrescine amidase

N-carbamoylputrescine_amidase

9

IPR017756

17,756

Transmembrane Gly-Cys-Arg, conserved site

TM_Gly-Cys-Arg_CS

Conserved_site

1,111

false

This entry represents a small (about 30 amino acids), hydrophobic, moderately conserved transmembrane helix-containing region. It is found once per protein, but in many proteins per genome in several bacteria of the order Myxococcales. The region begins with a signature Gly-Cys motif; other features, including a hydrop...

[]

0

[ "NCBIFAM" ]

[ "TIGR03382" ]

[ "GC_trans_RRR" ]

[ 1111 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 3, 1060, 31, 17 ]

4

[]

0

true

Conserved_site

Transmembrane Gly-Cys-Arg, conserved site

TM_Gly-Cys-Arg_CS

6

IPR017758

17,758

Coenzyme A disulphide reductase

CoA_disulphide_reductase

Family

438

false

Coenzyme A disulphide reductase ( ) has been characterised in Staphylococcus aureus, Pyrococcus horikoshii, and Borrelia burgdorferi (Lyme disease spirochete), and inferred in several other species on the basis of high levels of CoA and an absence of glutathione as a protective thiol. Coenzyme A disulphide reductase sp...

[ "GO:0003756", "GO:0050451", "GO:0050660", "GO:0050661" ]

[ "protein disulfide isomerase activity", "CoA-disulfide reductase (NADPH) activity", "flavin adenine dinucleotide binding", "NADP binding" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function" ]

4

[ "NCBIFAM" ]

[ "TIGR03385" ]

[ "CoA_CoA_reduc" ]

[ 438 ]

1

[ "EC" ]

[ "1.8.1.14" ]

[ "EC:1.8.1.14" ]

1

[ "1yqz", "3icr", "3ics", "3ict", "3kd9", "4em3", "4em4", "4emw", "4eqr", "4eqs", "4eqw", "4eqx", "4fx9", "5l1n" ]

14

[ "PUB00038606", "PUB00044719", "PUB00096676", "PUB00096677" ]

[ "16981688", "18399646", "23530771", "24723088" ]

[ "Structure of coenzyme A-disulfide reductase from Staphylococcus aureus at 1.54 A resolution.", "Pyridine nucleotide complexes with Bacillus anthracis coenzyme A-disulfide reductase: a structural analysis of dual NAD(P)H specificity.", "Structure and substrate specificity of the pyrococcal coenzyme A disulfide ...

[ 2006, 2008, 2013, 2014 ]

4

[]

[ "IPR023536" ]

0

1

0

[ "Archaea", "Bacteria" ]

[ 61, 377 ]

2

[]

0

true

Family

Coenzyme A disulphide reductase

CoA_disulphide_reductase

7

IPR017760

17,760

L-ascorbate oxidase, plants

L-ascorbate_oxidase_pln

Family

1,605

false

This entry represents the copper-containing enzyme L-ascorbate oxidase ( ), also called ascorbase. These enzymes are found in flowering plants, and show greater sequence similarity to a family of laccases ( ) from plants than to other known ascorbate oxidases.

[ "GO:0005507", "GO:0005576" ]

[ "copper ion binding", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR03388" ]

[ "ascorbase" ]

[ 1605 ]

1

[ "EC" ]

[ "1.10.3.3" ]

[ "EC:1.10.3.3" ]

1

[ "1aoz", "1aso", "1asp", "1asq" ]

4

[]

0

[ "IPR045087" ]

[]

1

0

1

[ "Embryophyta" ]

[ 1605 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 19, 9, 10 ]

3

true

Family

L-ascorbate oxidase, plants

L-ascorbate_oxidase_pln

2

IPR017761

17,761

Laccase

Family

11,296

false

This entry represents the copper-containing enzyme laccase ( ), often present in mutiple copies in a single plant species, and additional, uncharacterised, closely related plant proteins termed laccase-like multicopper oxidases. These enzymes show considerable sequence similarity to the L-ascorbate oxidases ( ). Laccas...

[ "GO:0052716", "GO:0046274", "GO:0048046" ]

[ "hydroquinone:oxygen oxidoreductase activity", "lignin catabolic process", "apoplast" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR03389" ]

[ "laccase" ]

[ 11296 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.10.3.2", "PWY-5466", "PWY-5469", "PWY-5773", "PWY-6824" ]

[ "EC:1.10.3.2", "METACYC:PWY-5466", "METACYC:PWY-5469", "METACYC:PWY-5773", "METACYC:PWY-6824" ]

5

[ "6klg", "6kli", "6klj" ]

3

[ "PUB00083093" ]

[ "21063888" ]

[ "The laccase multigene family in Arabidopsis thaliana: towards addressing the mystery of their gene function(s)." ]

[ 2011 ]

1

[ "IPR045087" ]

[]

1

0

1

[ "Embryophyta" ]

[ 11296 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 66, 35, 55 ]

3

true

Family

Laccase

9

IPR017762

17,762

Multicopper oxidase, fungi

Multicopper_oxidase_fun

Family

749

false

This entry describes a family of fungal ascorbate oxidases, which form part of a larger family of multicopper oxidases that also includes plant ascorbate oxidases ( ), plant laccases and laccase-like proteins ( ). The protein from Acremonium sp. HI-25 has been characterised as an ascorbate oxidase, a multicopper oxidas...

[]

0

[ "NCBIFAM" ]

[ "TIGR03390" ]

[ "ascorbOXfungal" ]

[ 749 ]

1

[]

0

[ "7zn6" ]

1

[ "PUB00042942", "PUB00042943", "PUB00042944", "PUB00082627" ]

[ "7961590", "9858779", "18178155", "24816227" ]

[ "Characterization of ascorbate oxidase from Acremonium sp. HI-25.", "Cloning of a thermostable ascorbate oxidase gene from Acremonium sp. HI-25 and modification of the azide sensitivity of the enzyme by site-directed mutagenesis.", "Elucidation of the factors affecting the oxidative activity of Acremonium sp. H...

[ 1994, 1998, 2008, 2014 ]

4

[ "IPR045087" ]

[]

1

0

1

[ "Eukaryota" ]

[ 749 ]

1

[]

0

true

Family

Multicopper oxidase, fungi

Multicopper_oxidase_fun

6

IPR017763

17,763

Cysteine desulfurase, sulphur acceptor subunit CsdE

Cysteine_desulfurase_CsdE

Family

1,696

false

This entry represents CsdE (formerly known as YgdK), the sulphur acceptor subunit of a cysteine desulfurase. This protein, found as a paralogue of SufE in Escherichia coli, Yersinia pestis, Photorhabdus luminescens and related species, works together and physically interacts with CsdA (a paralogue of SufS). CsdA has cy...

[]

0

[ "NCBIFAM" ]

[ "TIGR03391" ]

[ "FeS_syn_CsdE" ]

[ 1696 ]

1

[ "GP", "GP" ]

[ "GenProp0739", "GenProp1174" ]

[ "GP:GenProp0739", "GP:GenProp1174" ]

2

[ "1ni7", "4lw4", "5eep", "5ft8", "5nq6" ]

5

[]

0

[]

0

null

[ "Bacteria", "Bracon brevicornis", "human gut metagenome" ]

[ 1694, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Cysteine desulfurase, sulphur acceptor subunit CsdE

Cysteine_desulfurase_CsdE

9

IPR017764

17,764

Indole-3-pyruvate decarboxylase, Enterobacteriaceae

IPDC_Enterobacteriaceae

Family

135

false

This entry represents Enterobacteriaceae indole-3-pyruvate decarboxylase, part of a pathway for biosynthesis of the plant growth hormone indole-3-acetic acid (IAA). Typically, these species interact with plants, either as pathogens or as beneficial, root-associated bacteria [ , ]. It was suggested that the release of I...

[ "GO:0047434", "GO:0009851" ]

[ "indolepyruvate decarboxylase activity", "auxin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03393" ]

[ "indolpyr_decarb" ]

[ 135 ]

1

[]

0

[ "1ovm", "8zk6", "8zk7", "8zk8", "8zk9", "8zka" ]

6

[ "PUB00015910", "PUB00060920" ]

[ "12752451", "8900003" ]

[ "Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid.", "Cloning and characterization of a locus encoding an indolepyruvate decarboxylase involved in indole-3-acetic acid synthesi...

[ 2003, 1996 ]

2

[ "IPR012110" ]

[]

1

0

1

[ "Gammaproteobacteria" ]

[ 135 ]

1

[]

0

true

Family

Indole-3-pyruvate decarboxylase, Enterobacteriaceae

IPDC_Enterobacteriaceae

8

IPR017765

17,765

Indole-3-pyruvate decarboxylase

IPDC

Family

187

false

This entry represents indole-3-pyruvate decarboxylase, part of a pathway for biosynthesis of the plant growth hormone indole-3-acetic acid (IAA) [ , ]. Typically, these species interact with plants, either as pathogens or as beneficial, root-associated bacteria [ , ]. It was suggested that the release of IAA benefits t...

[ "GO:0047434", "GO:0009851" ]

[ "indolepyruvate decarboxylase activity", "auxin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03394" ]

[ "indol_phenyl_DC" ]

[ 187 ]

1

[]

0

[ "2nxw", "2q5j", "2q5l", "2q5o", "2q5q" ]

5

[ "PUB00015910", "PUB00060919", "PUB00060920", "PUB00060924" ]

[ "12752451", "17952626", "8900003", "18248455" ]

[ "Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid.", "An ipdC gene knock-out of Azospirillum brasilense strain SM and its implications on indole-3-acetic acid biosynthesis and ...

[ 2003, 2008, 1996, 2008 ]

4

[ "IPR012110" ]

[]

1

0

1

[ "Bacteria", "mine drainage metagenome" ]

[ 185, 2 ]

2

[]

0

true

Family

Indole-3-pyruvate decarboxylase

IPDC

9

IPR017766

17,766

Sphingomyelinase C/phospholipase C

Sphingomyelinase/PLipase_C

Family

3,615

false

This entry represents the proteins sphingomyelinase C ( ) and phospholipase C ( ). Sphingomyelinase (also known as sphingomyelin phosphodiesterase) is a hydrolase enzyme involved in sphingolipid metabolism, breaking down sphingomyelin to phosphocholine and ceramide [ ]. However, some of these enzymes act as haemolysins...

[ "GO:0008081", "GO:0005576" ]

[ "phosphoric diester hydrolase activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "NCBIFAM", "CDD" ]

[ "TIGR03395", "cd09078" ]

[ "sphingomy", "nSMase" ]

[ 1112, 3615 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.4.12", "PWY-7277", "R-DDI-9840310", "R-HSA-5626978", "R-HSA-9840310", "R-MMU-5626978", "R-MMU-9840310", "R-RNO-5626978", "R-RNO-9840310" ]

[ "EC:3.1.4.12", "METACYC:PWY-7277", "REACTOME:R-DDI-9840310", "REACTOME:R-HSA-5626978", "REACTOME:R-HSA-9840310", "REACTOME:R-MMU-5626978", "REACTOME:R-MMU-9840310", "REACTOME:R-RNO-5626978", "REACTOME:R-RNO-9840310" ]

9

[ "1zwx", "2ddr", "2dds", "2ddt", "2uyr", "3i41", "3i46", "3i48", "3i5v", "3k55", "5uvg", "7cne" ]

12

[ "PUB00042945", "PUB00044692", "PUB00044693" ]

[ "7941863", "18826261", "17888620" ]

[ "[The cloning and expression of the gene for Staphylococcus aureus beta-hemolysin]", "Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis.", "A critical role for phospholipase C in protective immunity conferred by listeriolysin O-deficient Liste...

[ 1994, 2008, 2008 ]

3

[ "IPR038772" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Staphylococcus phage 3 AJ-2017", "metagenomes" ]

[ 1642, 1966, 1, 6 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 5, 2, 9 ]

4

true

Family

Sphingomyelinase C/phospholipase C

Sphingomyelinase/PLipase_C

9

IPR017767

17,767

Phosphocholine-specific phospholipase C

PC-PLC

Family

6,012

false

Proteins in this entry are bacterial phosphatidylcholine-hydrolysing, phospholipase C enzymes, with the characteristic domain architecture found in the hemolytyic (PlcH) and nonhemolytic (PlcN) secreted enzymes from Pseudomonas aeruginosa [ ]. PlcH hydrolyzes phosphatidylcholine to diacylglycerol and phosphocholine, bu...

[ "GO:0034480" ]

[ "phosphatidylcholine phospholipase C activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03396" ]

[ "PC_PLC" ]

[ 6012 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.1.4.3", "PWY-7782", "PWY-7783", "PWY-8052" ]

[ "EC:3.1.4.3", "METACYC:PWY-7782", "METACYC:PWY-7783", "METACYC:PWY-8052" ]

4

[ "8yk5", "9gy2", "9gye" ]

3

[ "PUB00070794" ]

[ "2120196" ]

[ "Molecular comparison of a nonhemolytic and a hemolytic phospholipase C from Pseudomonas aeruginosa." ]

[ 1990 ]

1

[ "IPR007312" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "plant metagenome" ]

[ 5997, 8, 7 ]

3

[]

0

true

Family

Phosphocholine-specific phospholipase C

PC-PLC

1

IPR017768

17,768

Acid phosphatase, AcpA

AcpA

Family

1,739

false

Acid phosphatase A catalyzes the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at low pH [ ]. AcpA hydrolyzes a variety of substrates, including p-nitrophenylphosphate (pNPP), p-nitrophenylphosphorylcholine (pNPPC), peptides containing phosph...

[ "GO:0003993" ]

[ "acid phosphatase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03397" ]

[ "acid_phos_Burk" ]

[ 1739 ]

1

[]

0

[]

0

[ "PUB00040150", "PUB00085720" ]

[ "16899453", "15935744" ]

[ "Structure of Francisella tularensis AcpA: prototype of a unique superfamily of acid phosphatases and phospholipases C.", "Crystallization of AcpA, a respiratory burst-inhibiting acid phosphatase from Francisella tularensis." ]

[ 2006, 2005 ]

2

[ "IPR007312" ]

[]

1

0

1

[ "Bacteria", "bioreactor metagenome" ]

[ 1738, 1 ]

2

[]

0

true

Family

Acid phosphatase, AcpA

AcpA

4

IPR017770

17,770

RNA 3'-terminal phosphate cyclase type 1

RNA3'_term_phos_cyc_type_1

Family

4,060

false

This entry represents the type 1 RNA 3'-terminal phosphate cyclases. RNA cyclases are a family of RNA-modifying enzymes that are conserved in eukaryotes, bacteria and archaea. Type 1 RNA 3'-terminal phosphate cyclases ( ) [ , ] catalyse the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA: ...

[ "GO:0003963", "GO:0006396" ]

[ "RNA-3'-phosphate cyclase activity", "RNA processing" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00200", "TIGR03399" ]

[ "RTC", "RNA_3prim_cycl" ]

[ 3176, 4048 ]

2

[ "EC" ]

[ "6.5.1.4" ]

[ "EC:6.5.1.4" ]

1

[ "1qmh", "1qmi", "3kgd", "3tut", "3tux", "3tv1", "3tw3", "4o89", "4o8j" ]

9

[ "PUB00001300", "PUB00003565", "PUB00042947" ]

[ "9184239", "2199762", "10790377" ]

[ "The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea.", "RNA 3'-terminal phosphate cyclase from HeLa cells.", "Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA bioge...

[ 1997, 1990, 2000 ]

3

[ "IPR000228" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 641, 1718, 1680, 21 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 2, 6, 3 ]

6

true

Family

RNA 3'-terminal phosphate cyclase type 1

RNA3'_term_phos_cyc_type_1

7

IPR017771

17,771

Cyanamide hydratase

Cyanamide_hydratase_HD

Family

1,418

false

These proteins are found mostly in the Ascomycota, a branch of fungi, and contain an HD domain typically found in metal-dependent phosphohydrolases. The only currently characterised protein in this entry, from the soil fungus Myrothecium verrucaria, is cyanamide hydratase ( ), a zinc-containing homohexamer that adds wa...

[]

0

[ "NCBIFAM" ]

[ "TIGR03401" ]

[ "cyanamide_fam" ]

[ 1418 ]

1

[ "EC" ]

[ "4.2.1.69" ]

[ "EC:4.2.1.69" ]

1

[ "6dk9", "6dka", "6dkc", "6dkd" ]

4

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1418 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 2 ]

2

true

Family

Cyanamide hydratase

Cyanamide_hydratase_HD

5

IPR017772

17,772

Cysteine desulfurase NifS, bacterial-type

Cys_deSase_NifS_bac-type

Family

2,947

false

This entry represents NifS, one of several related families of cysteine desulfurase involved in iron-sulphur (FeS) cluster biosynthesis. NifS is part of the NIF (nitrogen fixation) system, and is usually encoded with other nif genes involved in nitrogenase expression and nitrogen fixation. These proteins include a clad...

[ "GO:0030170", "GO:0031071", "GO:0006520" ]

[ "pyridoxal phosphate binding", "cysteine desulfurase activity", "amino acid metabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR03402" ]

[ "FeS_nifS" ]

[ 2947 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.8.1.7", "GenProp0742", "PWY-6823", "PWY-6892", "PWY-7250", "PWY-7892", "PWY-8164", "PWY-8165", "PWY-8452" ]

[ "EC:2.8.1.7", "GP:GenProp0742", "METACYC:PWY-6823", "METACYC:PWY-6892", "METACYC:PWY-7250", "METACYC:PWY-7892", "METACYC:PWY-8164", "METACYC:PWY-8165", "METACYC:PWY-8452" ]

9

[]

0

[]

0

[ "IPR016454" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Metazoa", "ecological metagenomes" ]

[ 198, 2700, 3, 46 ]

4

[]

0

true

Family

Cysteine desulfurase NifS, bacterial-type

Cys_deSase_NifS_bac-type

1

IPR017773

17,773

Cysteine desulfurase NifS, proteobacteria

Cys_deSase_NifS_proteobacteria

Family

421

false

This entry represents a NifS-like cysteine desulfurase, similar to the NifS protein of nitrogen-fixing bacteria, found almost exclusively within the epsilon division of the Proteobacteria. Like NifS, and unlike IscS, this protein is found as part of a system of just two proteins, a cysteine desulfurase and a scaffold, ...

[ "GO:0031071", "GO:0006534" ]

[ "cysteine desulfurase activity", "cysteine metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03403" ]

[ "nifS_epsilon" ]

[ 421 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.8.1.7", "GenProp0742", "PWY-6823", "PWY-6892", "PWY-7250", "PWY-7892", "PWY-8164", "PWY-8165", "PWY-8452" ]

[ "EC:2.8.1.7", "GP:GenProp0742", "METACYC:PWY-6823", "METACYC:PWY-6892", "METACYC:PWY-7250", "METACYC:PWY-7892", "METACYC:PWY-8164", "METACYC:PWY-8165", "METACYC:PWY-8452" ]

9

[ "5wt2", "5wt4", "5wt5", "5wt6", "5zsp", "5zsq", "5zsr", "5zss", "5zst", "6kg0", "6kg1", "7cet", "7ceu", "7xeq", "7xes", "9jwx" ]

16

[ "PUB00027872" ]

[ "11123951" ]

[ "Characterization of the NifU and NifS Fe-S cluster formation proteins essential for viability in Helicobacter pylori." ]

[ 2000 ]

1

[ "IPR016454" ]

[]

1

0

1

[ "Pseudomonadati", "ecological metagenomes" ]

[ 406, 15 ]

2

[]

0

true

Family

Cysteine desulfurase NifS, proteobacteria

Cys_deSase_NifS_proteobacteria

3

IPR017774

17,774

Bicupin, oxalate decarboxylase/oxidase

Bicupin_oxalate_deCO2ase/Oxase

Family

4,693

false

Proteins in this entry are known as bicupins as they posses two copies of the cupin domain. Two different activities have so far been identified in this group of proteins; oxalate decarboxylase activity( ) and oxalate oxidase activity ( ), although the latter has more often been found in distantly related monocupin (ge...

[ "GO:0033609" ]

[ "oxalate metabolic process" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR03404" ]

[ "bicupin_oxalic" ]

[ 4693 ]

1

[ "EC", "METACYC" ]

[ "4.1.1.2", "PWY-6698" ]

[ "EC:4.1.1.2", "METACYC:PWY-6698" ]

2

[ "1j58", "1l3j", "1uw8", "2uy8", "2uy9", "2uya", "2uyb", "2v09", "2vqa", "3s0m", "4met", "5hi0", "5vg3", "6l9i", "6tzp", "6ufi", "9gof" ]

17

[ "PUB00043110" ]

[ "16000768" ]

[ "Cloning and sequencing of two Ceriporiopsis subvermispora bicupin oxalate oxidase allelic isoforms: implications for the reaction specificity of oxalate oxidases and decarboxylases." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Nitrososphaeraceae", "bioreactor metagenome", "unclassified Klosneuvirinae" ]

[ 1744, 2943, 3, 1, 2 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Bicupin, oxalate decarboxylase/oxidase

Bicupin_oxalate_deCO2ase/Oxase

4

IPR017775

17,775

Alcohol dehydrogenase, iron-type, PsrA-like

ADH_Fe_PsrA-like

Family

347

false

This group of iron-containing alcohol dehydrogenases is found in genomic contexts indicating a role in the metabolism of phosphonates. Recurring neighboring proteins include phosphonopyruvate decarboxylase, phosphonoacetaldehyde hydrolase, and phosphonate ABC transporter subunits. Recently, it has been identified a mem...

[]

0

[ "NCBIFAM" ]

[ "TIGR03405" ]

[ "Phn_Fe-ADH" ]

[ 347 ]

1

[]

0

[]

0

[ "PUB00151378" ]

[ "35580139" ]

[ "An evolutionary conserved detoxification system for membrane lipid-derived peroxyl radicals in Gram-negative bacteria." ]

[ 2022 ]

1

[ "IPR035873" ]

[]

1

0

1

[ "Pseudomonadati", "hydrothermal vent metagenome" ]

[ 346, 1 ]

2

[]

0

true

Family

Alcohol dehydrogenase, iron-type, PsrA-like

ADH_Fe_PsrA-like

6

IPR017776

17,776

FeS assembly SUF system protein SufT, putative

FeS_assembly_SufT_put

Family

1,378

false

The function of these proteins is unknown but they are almost always encoded in operons for the SUF system of iron-sulphur cluster biosynthesis. In a few species the SUF system is present elsewhere on the chromosome. This group shares this property of association with the SUF system with a related group, . These groups...

[]

0

[ "NCBIFAM" ]

[ "TIGR03406" ]

[ "FeS_long_SufT" ]

[ 1378 ]

1

[ "GP" ]

[ "GenProp0137" ]

[ "GP:GenProp0137" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Knufia peltigerae", "unclassified sequences" ]

[ 1335, 1, 42 ]

3

[]

0

true

Family

FeS assembly SUF system protein SufT, putative

FeS_assembly_SufT_put

8

IPR017777

17,777

Urea ABC transporter, substrate-binding protein UrtA-like

ABC_urea-bd_UrtA

Family

7,811

false

This entry consists of ABC transporter substrate-binding proteins associated with urea transport and metabolism. This family includes UrtA from Cyanobacteria, which is encoded in an operon typically found adjacent to urease genes. It was shown in that disruption leads to the loss of high-affinity urea transport activit...

[]

0

[ "NCBIFAM", "CDD" ]

[ "TIGR03407", "cd06355" ]

[ "urea_ABC_UrtA", "PBP1_FmdD-like" ]

[ 7525, 7811 ]

2

[ "GP" ]

[ "GenProp0743" ]

[ "GP:GenProp0743" ]

1

[ "7s6e", "7s6f", "8hic", "8tg1" ]

4

[ "PUB00042949", "PUB00080985" ]

[ "11929526", "9492267" ]

[ "An ABC-type, high-affinity urea permease identified in cyanobacteria.", "Characterisation of a binding-protein-dependent, active transport system for short-chain amides and urea in the methylotrophic bacterium Methylophilus methylotrophus." ]

[ 2002, 1998 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Nitrosopumilaceae", "unclassified sequences" ]

[ 7739, 13, 3, 56 ]

4

[]

0

true

Family

Urea ABC transporter, substrate-binding protein UrtA-like

ABC_urea-bd_UrtA

2

IPR017778

17,778

ABC transporter, urea, permease protein, UrtC

ABC_transptr_urea_perm_UrtC

Family

7,829

false

This entry consists of ABC transporter permease proteins associated with urea transport and metabolism. They are encoded in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR03408" ]

[ "urea_trans_UrtC" ]

[ 7829 ]

1

[ "GP" ]

[ "GenProp0743" ]

[ "GP:GenProp0743" ]

1

[]

0

[ "PUB00042949" ]

[ "11929526" ]

[ "An ABC-type, high-affinity urea permease identified in cyanobacteria." ]

[ 2002 ]

1

[ "IPR043428" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7752, 5, 72 ]

3

[]

0

true

Family

ABC transporter, urea, permease protein, UrtC

ABC_transptr_urea_perm_UrtC

5

IPR017780

17,780

ABC transporter, urea, ATP-binding protein, UrtE

ABC_transptr_urea_ATP-bd_UrtE

Family

7,543

false

This entry consists of ABC transporter ATP-binding proteins associated with urea transport and metabolism. They are encoded in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR03410" ]

[ "urea_trans_UrtE" ]

[ 7543 ]

1

[ "GP" ]

[ "GenProp0743" ]

[ "GP:GenProp0743" ]

1

[]

0

[ "PUB00042949" ]

[ "11929526" ]

[ "An ABC-type, high-affinity urea permease identified in cyanobacteria." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7468, 7, 68 ]

3

[]

0

true

Family

ABC transporter, urea, ATP-binding protein, UrtE

ABC_transptr_urea_ATP-bd_UrtE

6

IPR017782

17,782

Hydroxyacylglutathione hydrolase

Hydroxyacylglutathione_Hdrlase

Family

17,098

false

This entry represents hydroxyacylglutathione hydrolase, a detoxification enzyme also known as glyoxalase II. It follows lactoylglutathione lyase, also known as glyoxalase I, and acts to remove the toxic metabolite methylglyoxal and related compounds. This protein belongs to the broader metallo-beta-lactamase family [ ,...

[ "GO:0004416", "GO:0051596" ]

[ "hydroxyacylglutathione hydrolase activity", "methylglyoxal catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF", "NCBIFAM" ]

[ "MF_01374", "PIRSF005457", "TIGR03413" ]

[ "Glyoxalase_2", "Glx", "GSH_gloB" ]

[ 16567, 12762, 16726 ]

3

[ "EC", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.2.6", "GenProp0744", "GenProp1578", "PWY-5386", "R-BTA-70268", "R-DDI-70268", "R-DRE-70268", "R-GGA-70268", "R-HSA-70268", "R-HSA-9864848", "R-MMU-70268", "R-RNO-70268" ]

[ "EC:3.1.2.6", "GP:GenProp0744", "GP:GenProp1578", "METACYC:PWY-5386", "REACTOME:R-BTA-70268", "REACTOME:R-DDI-70268", "REACTOME:R-DRE-70268", "REACTOME:R-GGA-70268", "REACTOME:R-HSA-70268", "REACTOME:R-HSA-9864848", "REACTOME:R-MMU-70268", "REACTOME:R-RNO-70268" ]

12

[ "1qh3", "1qh5", "1xm8", "2q42", "2qed", "6rz0", "6s0i", "8ewo" ]

8

[ "PUB00043111", "PUB00043112" ]

[ "17196158", "10882093" ]

[ "Escherichia coli glyoxalase II is a binuclear zinc-dependent metalloenzyme.", "Detection and characterisation of the genes encoding glyoxalase I and II from Neisseria meningitidis." ]

[ 2007, 2000 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10304, 6689, 105 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 19, 1, 2, 5, 1, 8, 6, 5, 8, 1, 13 ]

11

true

Family

Hydroxyacylglutathione hydrolase

Hydroxyacylglutathione_Hdrlase

7

IPR017783

17,783

Choline ABC transporter, substrate-binding protein

ABC_choline_sub-bd

Family

6,027

false

Partial phylogenetic profiling [ ] suggests that the ABC transporter periplasmic binding proteins in this entry are involved in choline uptake for glycine betaine biosynthesis. Genomes often carry several paralogs, one encoded together with the permease and ATP-binding components, and another encoded next to a choline-...

[ "GO:0033265", "GO:0015871", "GO:0042597" ]

[ "choline binding", "choline transport", "periplasmic space" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM", "CDD" ]

[ "TIGR03414", "cd13640" ]

[ "ABC_choline_bnd", "PBP2_ChoX" ]

[ 5606, 6027 ]

2

[ "GP", "GP" ]

[ "GenProp0748", "GenProp0749" ]

[ "GP:GenProp0748", "GP:GenProp0749" ]

2

[ "2reg", "2rej", "2rf1", "2rin", "3hcq" ]

5

[ "PUB00034422", "PUB00042950", "PUB00062319" ]

[ "16930487", "15342567", "21803998" ]

[ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.", "The Sinorhizobium meliloti ABC transporter Cho is highly specific for choline and expressed in bacteroids from Medicago sativa nodules.", "Choline upta...

[ 2006, 2004, 2011 ]

3

[]

0

null

[ "Bacteria", "Steinernema glaseri", "unclassified sequences" ]

[ 6014, 1, 12 ]

3

[]

0

true

Family

Choline ABC transporter, substrate-binding protein

ABC_choline_sub-bd

7

IPR017784

17,784

ABC transporter, choline, permease protein

ABC_transptr_choline_permease

Family

2,460

false

Partial phylogenetic profiling [ ] suggests that the ABC transporter permease proteins in this entry are involved in choline uptake for glycine betaine biosynthesis.

[]

0

[ "NCBIFAM" ]

[ "TIGR03416" ]

[ "ABC_choXWV_perm" ]

[ 2460 ]

1

[ "GP" ]

[ "GenProp0748" ]

[ "GP:GenProp0748" ]

1

[]

0

[ "PUB00034422" ]

[ "16930487" ]

[ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Effrenium voratum", "ecological metagenomes" ]

[ 2453, 1, 6 ]

3

[]

0

true

Family

ABC transporter, choline, permease protein

ABC_transptr_choline_permease

5

IPR017785

17,785

Choline-sulfatase

Family

3,682

false

This entry consists of known and predicted choline-sulphatase enzymes involved in the synthesis of glycine betaine from choline [ , ]. The symbiotic soil bacterium Rhizobium meliloti can synthesise glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress [ , ]. Glycine betaine biosynthe...

[]

0

[ "NCBIFAM", "CDD" ]

[ "TIGR03417", "cd16032" ]

[ "chol_sulfatase", "choline-sulfatase" ]

[ 3673, 3466 ]

2

[ "GP" ]

[ "GenProp0749" ]

[ "GP:GenProp0749" ]

1

[ "6fny", "6g5z", "6g60", "7pth", "7ptj" ]

5

[ "PUB00013493", "PUB00042951", "PUB00044122", "PUB00044123" ]

[ "9141699", "9736747", "12906115", "17116241" ]

[ "Molecular characterization of the bet genes encoding glycine betaine synthesis in Sinorhizobium meliloti 102F34.", "Presence of a gene encoding choline sulfatase in Sinorhizobium meliloti bet operon: choline-O-sulfate is metabolized into glycine betaine.", "The Sinorhizobium meliloti glycine betaine biosynthet...

[ 1997, 1998, 2003, 2006 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2646, 1018, 18 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Zea mays" ]

[ 1, 1 ]

2

true

Family

Choline-sulfatase

4

IPR017786

17,786

Choline sulfate utilization transcriptional regulator

TF_choline_sulphate-util

Family

1,243

false

This entry consists of transcription factors from the wider LysR family whose genes are typically divergently transcribed from choline-sulphatase genes. Choline-sulphatase synthesises choline, a precursor to the osmoprotectant glycine-betaine, by the hydrolysis of choline sulphate.

[]

0

[ "NCBIFAM" ]

[ "TIGR03418" ]

[ "chol_sulf_TF" ]

[ 1243 ]

1

[ "GP" ]

[ "GenProp0749" ]

[ "GP:GenProp0749" ]

1

[]

0

[]

0

[ "IPR058163" ]

[]

1

0

1

[ "Pseudomonadota" ]

[ 1243 ]

1

[]

0

true

Family

Choline sulfate utilization transcriptional regulator

TF_choline_sulphate-util

1

IPR017787

17,787

NIF system FeS cluster assembly, NifU-like

NIF_FeS_clus_asmbl_NifU-like

Family

1,693

false

Iron-sulphur (FeS) clusters are important cofactors for numerous proteins involved in electron transfer, in redox and non-redox catalysis, in gene regulation, and as sensors of oxygen and iron. These functions depend on the various FeS cluster prosthetic groups, the most common being [2Fe-2S] and [4Fe-4S] [ ]. FeS clus...

[]

0

[ "NCBIFAM" ]

[ "TIGR03419" ]

[ "NifU_clost" ]

[ 1693 ]

1

[ "GP" ]

[ "GenProp0742" ]

[ "GP:GenProp0742" ]

1

[ "4eb5", "4eb7", "7c8m", "7c8n", "7c8o", "7cnv" ]

6

[ "PUB00003442", "PUB00028014", "PUB00035635", "PUB00035636", "PUB00035637", "PUB00035638", "PUB00035639", "PUB00035640" ]

[ "8875867", "11498000", "16221578", "16211402", "16843540", "15937904", "17350000", "15278785" ]

[ "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution.", "Incorporation of iron-sulphur clusters in membrane-bound proteins.", "How Escherichia coli and Saccharomyces cerevisiae build Fe/S proteins.", "Mechanisms of iron-sulfur cluster assembly: the SUF machinery.", ...

[ 1996, 2001, 2005, 2005, 2006, 2005, 2007, 2004 ]

8

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 196, 1440, 57 ]

3

[]

0

true

Family

NIF system FeS cluster assembly, NifU-like

NIF_FeS_clus_asmbl_NifU-like

8

IPR017788

17,788

DnaA regulatory inactivator Hda

Hda

Family

5,424

false

This entry represents the Hda (Homologous to DnaA) proteins, which are about half the length of DnaA and homologous over the entire length of Hda. In Escherichia coli, the initiation of DNA replication requires DnaA bound to ATP rather than ADP; Hda helps facilitate the conversion of DnaA-ATP to DnaA-ADP, thus inhibiti...

[ "GO:0032297" ]

[ "negative regulation of DNA-templated DNA replication initiation" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR03420" ]

[ "DnaA_homol_Hda" ]

[ 5424 ]

1

[ "GP", "GP" ]

[ "GenProp1162", "GenProp1186" ]

[ "GP:GenProp1162", "GP:GenProp1186" ]

2

[ "3bos", "3sc3", "5x06" ]

3

[ "PUB00042952" ]

[ "16882985" ]

[ "Hda-mediated inactivation of the DnaA protein and dnaA gene autoregulation act in concert to ensure homeostatic maintenance of the Escherichia coli chromosome." ]

[ 2006 ]

1

[ "IPR020591" ]

[ "IPR022864" ]

1

0

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 5356, 3, 65 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DnaA regulatory inactivator Hda

Hda

3

IPR017789

17,789

Frataxin

Family

3,670

false

Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia [ ]. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulphur cluster assembly, and designated CyaY. Friedreich's ataxia is a progressive neurodegenerative disorder caused by loss...

[ "GO:0004322", "GO:0006879", "GO:0018283", "GO:0005739" ]

[ "ferroxidase activity", "intracellular iron ion homeostasis", "iron incorporation into metallo-sulfur cluster", "mitochondrion" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR03422" ]

[ "mito_frataxin" ]

[ 3670 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "1.16.3.1", "R-BTA-1268020", "R-BTA-1362409", "R-BTA-9854311", "R-BTA-9865881", "R-CEL-1362409", "R-CEL-9854311", "R-DDI-1362409", "R-DDI-9854311", "R-DDI-9865881", "R-DME-1362409", "R-DME-9854311", "R-DME-9865881", "R-HSA-1268020", "R-HSA-1362409", "R-HSA-9854311", "R-HSA-9865881", ...

[ "EC:1.16.3.1", "REACTOME:R-BTA-1268020", "REACTOME:R-BTA-1362409", "REACTOME:R-BTA-9854311", "REACTOME:R-BTA-9865881", "REACTOME:R-CEL-1362409", "REACTOME:R-CEL-9854311", "REACTOME:R-DDI-1362409", "REACTOME:R-DDI-9854311", "REACTOME:R-DDI-9865881", "REACTOME:R-DME-1362409", "REACTOME:R-DME-985...

33

[ "1ekg", "1ly7", "2fql", "2ga5", "3oeq", "3oer", "3s4m", "3s5d", "3s5e", "3s5f", "3t3j", "3t3k", "3t3l", "3t3t", "3t3x", "4ec2", "5kz5", "5t0v", "5tre", "6fco", "6nzu", "7n9i", "8pk8", "8pk9", "8rme", "9jb5" ]

26

[ "PUB00003904", "PUB00004328", "PUB00005217", "PUB00005550" ]

[ "9241270", "8815938", "8596916", "8931268" ]

[ "Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin.", "Clinical and genetic abnormalities in patients with Friedreich's ataxia.", "Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion.", "Friedreich's ataxia protein: phyl...

[ 1997, 1996, 1996, 1996 ]

4

[ "IPR002908" ]

[]

1

0

1

[ "Eukaryota" ]

[ 3670 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 2, 1, 3, 4, 1, 3, 2, 1, 1, 9 ]

12

true

Family

Frataxin

9

IPR017790

17,790

Penicillin-binding protein 2

Penicillin-binding_protein_2

Family

16,832

false

This entry represents penicillin-binding protein 2 (PBP-2, also known as peptidoglycan D,D-transpeptidase MrdA), a protein whose gene (designated either pbpA or mrdA) is generally found next to the gene for RodA, a protein required for the rod (bacillus) shape in many bacteria [ ]. PBP-2 acts as a transpeptidase for ce...

[ "GO:0008658", "GO:0009002", "GO:0009252", "GO:0016020" ]

[ "penicillin binding", "serine-type D-Ala-D-Ala carboxypeptidase activity", "peptidoglycan biosynthetic process", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "HAMAP", "NCBIFAM" ]

[ "MF_02081", "TIGR03423" ]

[ "MrdA_transpept", "pbp2_mrdA" ]

[ 7950, 16832 ]

2

[ "EC", "GP", "METACYC", "METACYC" ]

[ "3.4.16.4", "GenProp0166", "PWY-5265", "PWY-6471" ]

[ "EC:3.4.16.4", "GP:GenProp0166", "METACYC:PWY-5265", "METACYC:PWY-6471" ]

4

[ "5lp4", "5lp5", "6g9f", "6g9p", "6g9s", "6tii", "6tix", "6xv5", "7kis", "7zg8", "8tj3", "8yjx", "8zpc" ]

13

[ "PUB00042955" ]

[ "2644207" ]

[ "Nucleotide sequence of the rodA gene, responsible for the rod shape of Escherichia coli: rodA and the pbpA gene, encoding penicillin-binding protein 2, constitute the rodA operon." ]

[ 1989 ]

1

[ "IPR050515" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 16467, 20, 345 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Penicillin-binding protein 2

Penicillin-binding_protein_2

4

IPR017792

17,792

Urea amidolyase associated protein 1

UAAP1

Family

2,981

false

A number of bacteria utilise urea as a nitrogen source by the urea carboxylase/allophanate hydrolase pathway, which uses biotin and consumes ATP, rather than by means of the nickel-dependent enzyme urease [ ]. This entry represents urea amidolyase associated protein 1 (UAAP1), one of a pair of homologous, tandem unchar...

[]

0

[ "NCBIFAM" ]

[ "TIGR03425" ]

[ "urea_degr_2" ]

[ 2981 ]

1

[ "GP" ]

[ "GenProp0481" ]

[ "GP:GenProp0481" ]

1

[]

0

[ "PUB00034523", "PUB00153578" ]

[ "15090492", "27452902" ]

[ "Enzymatic characterization of a prokaryotic urea carboxylase.", "The urea carboxylase and allophanate hydrolase activities of urea amidolyase are functionally independent." ]

[ 2004, 2016 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2959, 4, 18 ]

3

[]

0

true

Family

Urea amidolyase associated protein 1

UAAP1

8

IPR017793

17,793

ABC transporter, urea utilisation-associated, substrate-binding protein

ABC_transptr_urea-assoc_sub-bd

Family

1,759

false

This entry consists of ABC transporter substrate-binding proteins associated with the urea carboxylase/allophanate hydrolase pathway, an alternative to urease for urea degradation. These proteins are specific to bacteria with the urea degradation pathway and are encoded close to the urea carboxylase and allophanate hyd...

[]

0

[ "NCBIFAM" ]

[ "TIGR03427" ]

[ "ABC_peri_uca" ]

[ 1759 ]

1

[ "GP" ]

[ "GenProp0481" ]

[ "GP:GenProp0481" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Symbiodiniaceae", "ecological metagenomes" ]

[ 1747, 2, 10 ]

3

[]

0

true

Family

ABC transporter, urea utilisation-associated, substrate-binding protein

ABC_transptr_urea-assoc_sub-bd

8

IPR017794

17,794

Urea carboxylase-associated, permease

Urea_CO2ase-assoc_permease

Family

323

false

A number of bacteria obtain nitrogen from urea by means of a biotin-and ATP-dependent urea degradation system distinct from the urease enzyme. The two characterised proteins of this system are the enzymes urea carboxylase and allophanate hydrolase, but other, uncharacterised proteins are encoded nearby in multiple orga...

[]

0

[ "NCBIFAM" ]

[ "TIGR03428" ]

[ "ureacarb_perm" ]

[ 323 ]

1

[]

0

[]

0

[]

0

[ "IPR002293" ]

[]

1

0

1

[ "Actinomycetes", "freshwater metagenome" ]

[ 322, 1 ]

2

[]

0

true

Family

Urea carboxylase-associated, permease

Urea_CO2ase-assoc_permease

1

IPR017795

17,795

Aromatic prenyltransferase, NscD-like

ABBA_NscD-like

Family

3,500

false

This entry represents fungal enzymes involved in secondary metabolite production such as Prenyltransferase nscD, Tryptophan dimethylallyltransferase, ftmPT2, LtxC from lyngbyatoxin biosynthesis and related proteins [ , ]. This family also includes some proteins from bacteria, such as TleC, which has being identified as...

[ "GO:0016765", "GO:0009820" ]

[ "transferase activity, transferring alkyl or aryl (other than methyl) groups", "alkaloid metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER", "NCBIFAM", "CDD" ]

[ "PF11991", "PTHR40627", "TIGR03429", "cd13929" ]

[ "Trp_DMAT", "", "arom_pren_DMATS", "PT-DMATS_CymD" ]

[ 3498, 3049, 2630, 2628 ]

4

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.5.1", "2.5.1.-", "PWY-4502", "PWY-4681", "PWY-5802", "PWY-5815", "PWY-5816", "PWY-5817", "PWY-5893", "PWY-5979", "PWY-6262", "PWY-6403", "PWY-6659", "PWY-6681", "PWY-6936", "PWY-7372", "PWY-7405", "PWY-7407", "PWY-7493", "PWY-7520", "PWY-7529", "PWY-7532", "PWY-7540", ...

[ "EC:2.5.1", "EC:2.5.1.-", "METACYC:PWY-4502", "METACYC:PWY-4681", "METACYC:PWY-5802", "METACYC:PWY-5815", "METACYC:PWY-5816", "METACYC:PWY-5817", "METACYC:PWY-5893", "METACYC:PWY-5979", "METACYC:PWY-6262", "METACYC:PWY-6403", "METACYC:PWY-6659", "METACYC:PWY-6681", "METACYC:PWY-6936", ...

44

[ "3i4x", "3i4z", "3o24", "3o2k", "4e0t", "4e0u", "4ld7", "4yl7", "4yla", "4yzj", "4yzk", "4yzl", "5inj", "5jxm", "5k9m", "5kcg", "5kcl", "5kcq", "5kcy", "5kd0", "5kd6", "5kda", "6os3", "6os5", "6os6", "6vy9", "6vya", "6zrx", "6zry", "6zrz", "6zs0", "7w8u"...

47

[ "PUB00042956", "PUB00042997", "PUB00080707", "PUB00089907", "PUB00090975", "PUB00154591", "PUB00155019" ]

[ "7488077", "14732265", "24992358", "21608094", "22287087", "23368997", "23758576" ]

[ "The Claviceps purpurea gene encoding dimethylallyltryptophan synthase, the committed step for ergot alkaloid biosynthesis.", "The determinant step in ergot alkaloid biosynthesis by an endophyte of perennial ryegrass.", "A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis.", "Geneti...

[ 1995, 2004, 2014, 2011, 2012, 2013, 2013 ]

7

[ "IPR033964" ]

[ "IPR012148" ]

1

0

[ "Bacteria", "Eukaryota" ]

[ 474, 3026 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Aromatic prenyltransferase, NscD-like

ABBA_NscD-like

7

IPR017796

17,796

Tryptophan dimethylallyltransferase

Trp_dimethylallylTrfase

Family

69

false

This entry represents the enzyme tryptophan dimethylallyltransferase ( ), which catalyses the first step of ergot alkaloid biosynthesis [ ]. Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants. This enzyme is part of a larger group of...

[ "GO:0050364", "GO:0035837" ]

[ "tryptophan dimethylallyltransferase activity", "ergot alkaloid biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03430" ]

[ "trp_dimet_allyl" ]

[ 69 ]

1

[ "EC", "METACYC" ]

[ "2.5.1.34", "PWY-6493" ]

[ "EC:2.5.1.34", "METACYC:PWY-6493" ]

2

[ "3i4x", "3i4z" ]

2

[ "PUB00042956", "PUB00044675" ]

[ "7488077", "18390548" ]

[ "The Claviceps purpurea gene encoding dimethylallyltryptophan synthase, the committed step for ergot alkaloid biosynthesis.", "Molecular analysis of a 4-dimethylallyltryptophan synthase from Malbranchea aurantiaca." ]

[ 1995, 2008 ]

2

[ "IPR012148" ]

[]

1

0

1

[ "leotiomyceta" ]

[ 69 ]

1

[]

0

true

Family

Tryptophan dimethylallyltransferase

Trp_dimethylallylTrfase

3

IPR017797

17,797

Phosphonate ABC transporter, substrate-binding protein

Phosphnate-bd

Family

3,174

false

This entry represents a subset of the broader family of phosphate/phosphonate binding protein ABC transporter components. Many of the proteins in this entry can be associated with pathways for the metabolism of phosphonates, particularly the C-P lyase system based on their genomic context; this includes the characteris...

[ "GO:0015716", "GO:0043190" ]

[ "organic phosphonate transport", "ATP-binding cassette (ABC) transporter complex" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR03431" ]

[ "PhnD" ]

[ 3174 ]

1

[ "GP", "GP" ]

[ "GenProp0232", "GenProp0236" ]

[ "GP:GenProp0232", "GP:GenProp0236" ]

2

[ "3n5l", "3p7i", "3qk6", "3quj", "3s4u" ]

5

[ "PUB00011671", "PUB00042957", "PUB00071925", "PUB00071938" ]

[ "2155230", "16751609", "18310026", "8003968" ]

[ "Molecular biology of carbon-phosphorus bond cleavage. Cloning and sequencing of the phn (psiD) genes involved in alkylphosphonate uptake and C-P lyase activity in Escherichia coli B.", "Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent bi...

[ 1990, 2006, 2008, 1994 ]

4

[ "IPR005770" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "ecological metagenomes" ]

[ 3158, 5, 2, 9 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Phosphonate ABC transporter, substrate-binding protein

Phosphnate-bd

2

IPR017798

17,798

D-xylonate dehydratase YjhG/YagF

Dehydratase_YjhG/YagF

Family

617

false

Proteins in this entry are homologous to dihydroxy-acid dehydratases and have been found so far in two Acidobacteria, two Planctomycetes, Bacillus clausii (strain KSM-K16), and (in two copies each) in strains K12-MG1655 and W3110 of Escherichia coli. E. coli K-12 family strains have two D-xylonic acid dehydratases, Yjh...

[ "GO:0050401" ]

[ "xylonate dehydratase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03432" ]

[ "yjhG_yagF" ]

[ 617 ]

1

[]

0

[]

0

[ "PUB00076909", "PUB00086863" ]

[ "26083940", "23233208" ]

[ "Characterization of D-xylonate dehydratase YjhG from Escherichia coli.", "Biosynthesis of ethylene glycol in Escherichia coli." ]

[ 2015, 2013 ]

2

[]

0

null

[ "Bacteria", "Metazoa", "ecological metagenomes" ]

[ 610, 2, 5 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

D-xylonate dehydratase YjhG/YagF

Dehydratase_YjhG/YagF

1

IPR017799

17,799

Transcription regulator PadR, acidobacterial-type

Tscrpt_reg_PadR_acidobac-type

Family

894

false

Proteins in this entry are putative transcriptional regulators of the wider PadR family, and are found primarily in species of the acidobacteria. These proteins are regularly encoded in the vicinity of a putative transporter protein

[]

0

[ "NCBIFAM" ]

[ "TIGR03433" ]

[ "padR_acidobact" ]

[ 894 ]

1

[ "GP" ]

[ "GenProp0751" ]

[ "GP:GenProp0751" ]

1

[]

0

[]

0

[ "IPR052509" ]

[]

1

0

1

[ "Bacteria", "mine drainage metagenome" ]

[ 892, 2 ]

2

[]

0

true

Family

Transcription regulator PadR, acidobacterial-type

Tscrpt_reg_PadR_acidobac-type

6

IPR017800

17,800

Acidobacterial duplicated orphan permease

ADOP

Family

2,000

false

These proteins are found mostly in three species of Acidobacteria, namely Acidobacteria bacterium (strain Ellin345), Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus (strain Ellin6076), where they form large paralogous families. Each protein contains two copies of a predicted ABC transporter permease doama...

[]

0

[ "NCBIFAM" ]

[ "TIGR03434" ]

[ "ADOP" ]

[ 2000 ]

1

[ "GP" ]

[ "GenProp0751" ]

[ "GP:GenProp0751" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1987, 13 ]

2

[]

0

true

Family

Acidobacterial duplicated orphan permease

ADOP

6

IPR017801

17,801

Soil-associated protein DUF3738

DUF3738

Family

545

false

Bacterial reference strains encoding members of this protein family are all isolated from soil. These include members from Solibacter usitatus Ellin6076, 27 from Acidobacterium sp. MP5ACTX8 (both Acidobacteria), and four from Pedosphaera parvula Ellin514 (Verrucomicrobia). The family is well-diversified, with few pairs...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF12543", "TIGR03435" ]

[ "DUF3738", "Soli_TIGR03435" ]

[ 545, 404 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati" ]

[ 545 ]

1

[]

0

true

Family

Soil-associated protein DUF3738

DUF3738

1

IPR017802

17,802

VWFA-related, acidobacterial-type

VWFA-rel_acidobac-type

Family

1,085

false

This entry represents bacterial proteins that include a region related to the von Willebrand factor type A (VWFA) domain. These proteins are mostly found in the acidobacteria, where they have undergone a large paralogous expansion.

[]

0

[ "NCBIFAM" ]

[ "TIGR03436" ]

[ "acidobact_VWFA" ]

[ 1085 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Halobacteriales", "unclassified sequences" ]

[ 1026, 5, 54 ]

3

[]

0

true

Family

VWFA-related, acidobacterial-type

VWFA-rel_acidobac-type

2

IPR017803

17,803

Conserved hypothetical protein CHP03437-like, C-terminal

CHP03437-like_C

Domain

169

false

This entry describes a domain found in a group of uncharacterised proteins predominantly from actinobacteria. It is often found at the C-terminal end. It's function is unknown.

[]

0

[ "NCBIFAM" ]

[ "TIGR03437" ]

[ "Soli_cterm" ]

[ 169 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Penicillium decumbens", "marine sediment metagenome" ]

[ 167, 1, 1 ]

3

[]

0

true

Domain

Conserved hypothetical protein CHP03437-like, C-terminal

CHP03437-like_C

4

IPR017804

17,804

4-dimethylallyltryptophan N-methyltransferase easF

EasF

Family

8,391

false

This entry includes bacterial Histidine N-alpha-methyltransferase EgtD [ ], and fungal N-methyltransferases [ ]. Histidine-specific methyltransferase EgtD catalyses the methylations of histidine to form N-alpha, N-alpha ,N-alpha-trimethyl-L-histidine (also known as hercynine) [ ]. 4-Dimethylallyltryptophan N-methyltran...

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF018005" ]

[ "UCP018005" ]

[ 8391 ]

1

[ "EC", "GP" ]

[ "2.1.1", "GenProp0752" ]

[ "EC:2.1.1", "GP:GenProp0752" ]

2

[ "4pim", "4pin", "4pio", "4pip", "4uy5", "4uy6", "4uy7", "6fnq", "6fnr", "6fns", "6fnt", "7scf", "7sew", "7sex", "7sey", "7sf4", "7sf5" ]

17

[ "PUB00060032", "PUB00073496", "PUB00082573" ]

[ "20420449", "18678866", "24677498" ]

[ "In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.", "Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase.", "Cytochrome P450 as dimerization catalyst in diketopiperazine alkaloid biosynthesis...

[ 2010, 2008, 2014 ]

3

[ "IPR051128" ]

[ "IPR032888", "IPR035094" ]

1

2

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 76, 7476, 768, 71 ]

4

[]

0

true

Family

4-dimethylallyltryptophan N-methyltransferase easF

EasF

2

IPR017805

17,805

EasF-like, SAM-dependent methyltransferase domain

SAM_EasF-like

Domain

2,007

false

This entry represents a domain found across the full length of 4-dimethylallyltryptophan N-methyltransferase (EasF) and related fungal proteins. The domain is homologous to S-adenosylmethionine (SAM)-dependent methyltransferases . This domain can also be found covering the N-terminal region. EasF is involved in the bio...

[]

0

[ "NCBIFAM" ]

[ "TIGR03439" ]

[ "methyl_EasF" ]

[ 2007 ]

1

[ "EC" ]

[ "2.1.1" ]

[ "EC:2.1.1" ]

1

[]

0

[ "PUB00042962" ]

[ "1880714" ]

[ "Steric course of the N-methylation in the biosynthesis of ergot alkaloids by Claviceps purpurea." ]

[ 1991 ]

1

[ "IPR019257" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Nitrososphaerota", "marine metagenome" ]

[ 37, 1964, 5, 1 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Domain

EasF-like, SAM-dependent methyltransferase domain

SAM_EasF-like

3

IPR017806

17,806

Hercynine oxygenase

EgtB

Family

6,909

false

Hercynine oxygenase (EgtB) catalyses the oxidative sulfurisation of hercynine (Nα,Nα,Nα-trimethyl-L-histidine) to hercynyl-γ-L-glutamyl-L-cysteine sulfoxide, an intermediate step in the ergothioneine biosynthesis pathway. The enzyme is specific for its substrates: it cannot utilise cysteine, N-acetylcysteine or glutath...

[ "GO:0052699" ]

[ "ergothioneine biosynthetic process" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR03440" ]

[ "egtB_TIGR03440" ]

[ 6909 ]

1

[ "EC", "GP", "METACYC" ]

[ "1.14.99.50", "GenProp0752", "PWY-7255" ]

[ "EC:1.14.99.50", "GP:GenProp0752", "METACYC:PWY-7255" ]

3

[ "4x8b", "4x8d", "4x8e", "6o6l", "6o6m", "6qki", "6qkj", "8qf6" ]

8

[ "PUB00060032" ]

[ "20420449" ]

[ "In vitro reconstitution of Mycobacterial ergothioneine biosynthesis." ]

[ 2010 ]

1

[]

[ "IPR032890" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 53, 6803, 9, 44 ]

4

[]

0

true

Family

Hercynine oxygenase

EgtB

9

IPR017807

17,807

Urea transporter, bacteria

Urea_transporter_bac

Family

443

false

Proteins in this family are bacterial urea transporters, found in species that contain urease, encoded adjacent to the urease operon. YUT (Yersinia urea transporter) proteins from the Gram-negative bacterium Yersinia peseudotuberculosis are also included in this family. Putative Yut urea channel exists only in the open...

[ "GO:0015204", "GO:0071918", "GO:0016020" ]

[ "urea transmembrane transporter activity", "urea transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR03441" ]

[ "urea_trans_yut" ]

[ 443 ]

1

[]

0

[]

0

[ "PUB00060293" ]

[ "17264989" ]

[ "Urea transport in bacteria: acid acclimation by gastric Helicobacter spp." ]

[ 2006 ]

1

[ "IPR004937" ]

[]

1

0

1

[ "Bacteria" ]

[ 443 ]

1

[]

0

true

Family

Urea transporter, bacteria

Urea_transporter_bac

2

IPR017808

17,808

Ergothioneine biosynthesis protein EgtC

EgtC

Family

2,449

false

Members of this strictly bacterial protein family show similarity to class II glutamine amidotransferases. They are distinguished by appearing in a genome context with, and usually adjacent to or between, members of families (methyltransferase EgtD-like) and (ergothioneine biosynthesis protein EgtB) [ ].

[ "GO:0052699" ]

[ "ergothioneine biosynthetic process" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR03442" ]

[ "" ]

[ 2449 ]

1

[ "EC", "GP", "METACYC" ]

[ "3.5.1.118", "GenProp0752", "PWY-7255" ]

[ "EC:3.5.1.118", "GP:GenProp0752", "METACYC:PWY-7255" ]

3

[ "4zfj", "4zfk", "4zfl" ]

3

[ "PUB00060032" ]

[ "20420449" ]

[ "In vitro reconstitution of Mycobacterial ergothioneine biosynthesis." ]

[ 2010 ]

1

[ "IPR026869" ]

[ "IPR032889" ]

1

0

[ "Bacteria", "ecological metagenomes" ]

[ 2445, 4 ]

2

[]

0

true

Family

Ergothioneine biosynthesis protein EgtC

EgtC

2

IPR017809

17,809

Glutamate--cysteine ligase EgtA, Actinobacteria

EgtA_Actinobacteria

Family

2,423

false

Members of this bacterial protein family, EgtA, resemble the glutamate--cysteine ligase of the two-step pathway for glutathione (GSH) biosynthesis, but instead are involved in the biosynthesis of the histidine-derived thiol, ergothioneine (EGT). Successful in vitro reconstitution of EGT biosynthesis using EgtBCDE and g...

[ "GO:0004357", "GO:0052699" ]

[ "glutamate-cysteine ligase activity", "ergothioneine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_02034", "TIGR03444" ]

[ "EgtA", "EgtA_Cys_ligase" ]

[ 2418, 2052 ]

2

[ "EC", "GP", "METACYC", "METACYC", "METACYC" ]

[ "6.3.2.2", "GenProp0752", "PWY-6840", "PWY-7255", "PWY-8043" ]

[ "EC:6.3.2.2", "GP:GenProp0752", "METACYC:PWY-6840", "METACYC:PWY-7255", "METACYC:PWY-8043" ]

5

[]

0

[ "PUB00060032" ]

[ "20420449" ]

[ "In vitro reconstitution of Mycobacterial ergothioneine biosynthesis." ]

[ 2010 ]

1

[ "IPR035434" ]

[]

1

0

1

[ "Actinomycetes", "Pleodorina starrii", "freshwater metagenome" ]

[ 2421, 1, 1 ]

3

[]

0

true

Family

Glutamate--cysteine ligase EgtA, Actinobacteria

EgtA_Actinobacteria

9

IPR017810

17,810

Mycothiol biosynthesis protein, MshB

Mycothiol_biosynthesis_MshB

Family

3,244

false

This entry represents the mycothiol biosynthesis protein MshB found in Mycobacterium tuberculosisand related species. This protein has been characterised as a 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase [ ].

[ "GO:0035595" ]

[ "N-acetylglucosaminylinositol deacetylase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_01696", "TIGR03445" ]

[ "MshB", "mycothiol_MshB" ]

[ 3023, 3241 ]

2

[ "EC", "GP" ]

[ "3.5.1.103", "GenProp0753" ]

[ "EC:3.5.1.103", "GP:GenProp0753" ]

2

[ "1q74", "1q7t", "4ewl" ]

3

[ "PUB00042965" ]

[ "16630724" ]

[ "Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme." ]

[ 2006 ]

1

[ "IPR003737" ]

[]

1

0

1

[ "Bacteria", "Halteria grandinella", "metagenomes" ]

[ 3117, 1, 126 ]

3

[]

0

true

Family

Mycothiol biosynthesis protein, MshB

Mycothiol_biosynthesis_MshB

6

IPR017811

17,811

Mycothiol S-conjugate amidase Mca

Mca

Family

4,107

false

Mycobacterium tuberculosis, Corynebacterium glutamicum (Brevibacterium flavum), and related species use the thiol mycothiol in place of glutathione. This enzyme, homologous to the (dispensable) MshB enzyme of mycothiol biosynthesis, is described as an amidase that acts on conjugates to mycothiol [ ], and functions as a...

[ "GO:0010126" ]

[ "mycothiol metabolic process" ]

[ "biological_process" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_01482", "TIGR03446" ]

[ "Mca", "mycothiol_Mca" ]

[ 4009, 4106 ]

2

[ "EC", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.5.1.115", "GenProp0923", "PWY-6955", "R-MTU-879235", "R-MTU-879299", "R-MTU-879325" ]

[ "EC:3.5.1.115", "GP:GenProp0923", "METACYC:PWY-6955", "REACTOME:R-MTU-879235", "REACTOME:R-MTU-879299", "REACTOME:R-MTU-879325" ]

6

[]

0

[ "PUB00042966" ]

[ "14556638" ]

[ "Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase." ]

[ 2003 ]

1

[ "IPR003737" ]

[]

1

0

1

[ "Bacteria", "Rhynchospora breviuscula", "metagenomes" ]

[ 4051, 1, 55 ]

3

[]

0

true

Family

Mycothiol S-conjugate amidase Mca

Mca

8

IPR017812

17,812

Mycothiol ligase MshC

Mycothiol_ligase_MshC

Family

3,982

false

This entry represents MshC, a l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis [ ]. This enzyme shows considerable homology to Cys--tRNA ligases, and many protei...

[ "GO:0035446", "GO:0010125" ]

[ "cysteine-glucosaminylinositol ligase activity", "mycothiol biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01697", "TIGR03447" ]

[ "MshC", "mycothiol_MshC" ]

[ 3783, 3980 ]

2

[ "EC", "GP", "REACTOME" ]

[ "6.3.1.13", "GenProp0753", "R-MTU-879299" ]

[ "EC:6.3.1.13", "GP:GenProp0753", "REACTOME:R-MTU-879299" ]

3

[ "3c8z", "8hfm", "8hfn", "8hfo" ]

4

[ "PUB00042967", "PUB00056790" ]

[ "16674910", "14594852" ]

[ "A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening.", "Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman." ]

[ 2006, 2003 ]

2

[ "IPR024909" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3867, 2, 113 ]

3

[]

0

true

Family

Mycothiol ligase MshC

Mycothiol_ligase_MshC

8

IPR017813

17,813

Mycothiol acetyltransferase

Mycothiol_AcTrfase

Family

3,971

false

Low-molecular weight thiols play an essential role in the metabolism of organsism as coenzymes and cofactors that facilitate important biochemical processes in conjunction with proteins. The predominant low-molecular weight thiol in the actinomycetes is mycothiol, which is involved in the maintenance of cellualar redox...

[ "GO:0016747" ]

[ "acyltransferase activity, transferring groups other than amino-acyl groups" ]

[ "molecular_function" ]

1

[ "HAMAP", "PIRSF", "NCBIFAM" ]

[ "MF_01698", "PIRSF021524", "TIGR03448" ]

[ "MshD", "MSH_acetyltransferase", "mycothiol_MshD" ]

[ 3757, 3680, 3961 ]

3

[ "EC", "GP", "REACTOME" ]

[ "2.3.1.189", "GenProp0753", "R-MTU-879299" ]

[ "EC:2.3.1.189", "GP:GenProp0753", "REACTOME:R-MTU-879299" ]

3

[ "1ozp", "1p0h", "2c27" ]

3

[ "PUB00043431", "PUB00043432", "PUB00043433" ]

[ "11544359", "12384335", "12375100" ]

[ "Novel thiols of prokaryotes.", "Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics.", "Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes." ]

[ 2001, 2002, 2002 ]

3

[]

0

null

[ "Bacteria", "Didymella rabiei", "metagenomes" ]

[ 3879, 1, 91 ]

3

[]

0

true

Family

Mycothiol acetyltransferase

Mycothiol_AcTrfase

3

IPR017814

17,814

Mycothiol biosynthesis protein, MshA

Mycothiol_biosynthesis_MshA

Family

3,481

false

Members of this protein family, found exclusively in the Actinobacteria, are MshA, the glycosyltransferase of mycothiol biosynthesis [ ]. Mycothiol replaces glutathione in these species.

[ "GO:0008375", "GO:0010125" ]

[ "acetylglucosaminyltransferase activity", "mycothiol biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01695", "TIGR03449" ]

[ "MshA", "mycothiol_MshA" ]

[ 3397, 3422 ]

2

[ "EC", "GP", "REACTOME" ]

[ "2.4.1.250", "GenProp0753", "R-MTU-879299" ]

[ "EC:2.4.1.250", "GP:GenProp0753", "REACTOME:R-MTU-879299" ]

3

[ "3c48", "3c4q", "3c4v" ]

3

[ "PUB00042968" ]

[ "16940050" ]

[ "Biochemistry of the initial steps of mycothiol biosynthesis." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3386, 2, 93 ]

3

[]

0

true

Family

Mycothiol biosynthesis protein, MshA

Mycothiol_biosynthesis_MshA

9

IPR017815

17,815

Myo-inositol 1-phosphate synthase, actinobacteria

Myo-inos-1-P_Synthase_actino

Family

3,518

false

This entry represents Inositol-3-phosphate synthase 1 (INO1), also known as Myo-inositol 1-phosphate synthase, and similar sequences found in actinobacteria. INO1 is a key enzyme in myo-inositol biosynthesis pathway that catalyses the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate in a NAD-dependent m...

[]

0

[ "NCBIFAM" ]

[ "TIGR03450" ]

[ "mycothiol_INO1" ]

[ 3518 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME" ]

[ "5.5.1.4", "GenProp1244", "PWY-2301", "PWY-4661", "PWY-6372", "PWY-6580", "PWY-6664", "R-MTU-879299" ]

[ "EC:5.5.1.4", "GP:GenProp1244", "METACYC:PWY-2301", "METACYC:PWY-4661", "METACYC:PWY-6372", "METACYC:PWY-6580", "METACYC:PWY-6664", "REACTOME:R-MTU-879299" ]

8

[ "1gr0" ]

1

[ "PUB00036813", "PUB00042969", "PUB00101379", "PUB00106885" ]

[ "12005437", "10448034", "35725777", "35080445" ]

[ "Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis.", "Identification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme.", "Characterization of inositol lipid metabol...

[ 2002, 1999, 2022, 2022 ]

4

[ "IPR002587" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3448, 2, 68 ]

3

[]

0

true

Family

Myo-inositol 1-phosphate synthase, actinobacteria

Myo-inos-1-P_Synthase_actino

9

IPR017816

17,816

S-(hydroxymethyl)mycothiol dehydrogenase

MycoS_dep_FDH

Family

4,174

false

Members of this family are mycothiol-dependent formaldehyde dehydrogenase enzymes ( ) [ ]. This protein is found, so far, only in the Actinobacteria (Mycobacterium species, Streptomyces species, Corynebacterium species and related species), where mycothione replaces glutathione.

[]

0

[ "NCBIFAM" ]

[ "TIGR03451" ]

[ "mycoS_dep_FDH" ]

[ 4174 ]

1

[ "GP" ]

[ "GenProp0923" ]

[ "GP:GenProp0923" ]

1

[]

0

[ "PUB00042970" ]

[ "9202149" ]

[ "Mycothiol, 1-O-(2'-[N-acetyl-L-cysteinyl]amido-2'-deoxy-alpha-D-glucopyranosyl)-D- myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4133, 7, 34 ]

3

[]

0

true

Family

S-(hydroxymethyl)mycothiol dehydrogenase

MycoS_dep_FDH

3

IPR017817

17,817

Mycothione reductase

Mycothione_reductase

Family

1,155

false

Mycothiol, a glutathione analog in Mycobacterium tuberculosis and related species, can form a disulphide-linked dimer called mycothione. This enzyme can reduce mycothione to regenerate two mycothiol molecules. The enzyme shows some sequence similarity to glutathione-disulphide reductase, trypanothione-disulphide reduct...

[]

0

[ "NCBIFAM" ]

[ "TIGR03452" ]

[ "mycothione_red" ]

[ 1155 ]

1

[ "GP", "REACTOME" ]

[ "GenProp0923", "R-MTU-870331" ]

[ "GP:GenProp0923", "REACTOME:R-MTU-870331" ]

2

[ "8qcj", "8qck", "8rx4", "8rx5", "8rx6" ]

5

[ "PUB00042971" ]

[ "10512639" ]

[ "Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase." ]

[ 1999 ]

1

[ "IPR001100" ]

[]

1

0

1

[ "Actinomycetes", "freshwater metagenome" ]

[ 1153, 2 ]

2

[]

0

true

Family

Mycothione reductase

Mycothione_reductase

7

IPR017819

17,819

Plasmid partitioning protein, RepB

Plasmid_partition_RepB

Family

2,839

false

RepABC plasmids are generally very low copy-number and therefore depend on an efficient system of plasmid partitioning to enure their stability and replication [ ]. The partioning system in these plasmids involves two proteins, RepA and RepB, and centromere-like sequences known as parS. Mutations in RepA, RepB or parS ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03454" ]

[ "partition_RepB" ]

[ 2839 ]

1

[ "GP" ]

[ "GenProp0487" ]

[ "GP:GenProp0487" ]

1

[]

0

[ "PUB00043441" ]

[ "18433868" ]

[ "The repABC plasmid family." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota", "Ochrobactrum phage POI1126", "Plasmid pTiB6S3", "Pseudomonadota", "ecological metagenomes" ]

[ 3, 1, 1, 2820, 14 ]

5

[]

0

true

Family

Plasmid partitioning protein, RepB

Plasmid_partition_RepB

5

IPR017820

17,820

Sulphoacetaldehyde acetyltransferase

Sulphoacetald_Actrfrase

Family

1,458

false

Sulphoacetaldehyde acetyltransferase is a thiamine pyrophosphate-dependent enzyme involved in taurine utilization [ ]. Taurine, or 2-aminoethanesulphonate, can be used by bacteria as a source of carbon, nitrogen, and sulphur.

[ "GO:0000287", "GO:0030976", "GO:0050487", "GO:0019529", "GO:0005737" ]

[ "magnesium ion binding", "thiamine pyrophosphate binding", "sulfoacetaldehyde acetyltransferase activity", "taurine catabolic process", "cytoplasm" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "NCBIFAM" ]

[ "TIGR03457" ]

[ "sulphoacet_xsc" ]

[ 1458 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "2.3.3.15", "PWY-1281", "PWY-6637" ]

[ "EC:2.3.3.15", "METACYC:PWY-1281", "METACYC:PWY-6637" ]

3

[]

0

[ "PUB00027907" ]

[ "12358600" ]

[ "Sulphoacetaldehyde acetyltransferase yields acetyl phosphate: purification from Alcaligenes defragrans and gene clusters in taurine degradation." ]

[ 2003 ]

1

[ "IPR045229" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 6, 1405, 23, 24 ]

4

[]

0

true

Family

Sulphoacetaldehyde acetyltransferase

Sulphoacetald_Actrfrase

1

IPR017821

17,821

Succinate CoA transferase

Succinate_CoA_transferase

Family

5,753

false

These CoA transferases include enzyme catalyzing at least two related, but distinct, activities. The Escherichia coli YgfH protein has been characterised as a propionyl-CoA:succinate CoA transferase where it appears to be involved in a pathway for the decarboxylation of succinate to propionate [ ]. The Clostridium kluy...

[ "GO:0016740", "GO:0006084" ]

[ "transferase activity", "acetyl-CoA metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03458" ]

[ "YgfH_subfam" ]

[ 5753 ]

1

[ "GP" ]

[ "GenProp1723" ]

[ "GP:GenProp1723" ]

1

[ "2g39", "2nvv", "4eu3", "4eu4", "4eu5", "4eu6", "4eu7", "4eu8", "4eu9", "4eua", "4eub", "4euc", "4eud", "5ddk", "5dw4", "5dw5", "5dw6", "5e5h" ]

18

[ "PUB00019088", "PUB00042977", "PUB00042978", "PUB00062509" ]

[ "8550525", "10769117", "12606555", "23030530" ]

[ "Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri.", "Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli.", "Functional characterization and localization of acetyl-CoA hydrolase, Ach1p, in Saccharomyces cerevisiae.",...

[ 1996, 2000, 2003, 2012 ]

4

[ "IPR046433" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 5693, 26, 34 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Succinate CoA transferase

Succinate_CoA_transferase

8

IPR017822

17,822

Alpha-(1->6)-mannopyranosyltransferase A

MptA

Family

819

false

This entry represents a family of hydrophobic presumed membrane proteins found in actinobacteria, including Alpha-(1->6)-mannopyranosyltransferase A from Mycobacterium tuberculosis (MptA). MptA is involved in the latter stages of the biosynthesis of the alpha-(1->6) mannan core of lipomannan (LM) and catalyses the addi...

[]

0

[ "NCBIFAM" ]

[ "TIGR03459" ]

[ "crt_membr" ]

[ 819 ]

1

[ "GP" ]

[ "GenProp0758" ]

[ "GP:GenProp0758" ]

1

[]

0

[ "PUB00106744" ]

[ "17714444" ]

[ "Identification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis." ]

[ 2007 ]

1

[ "IPR049829" ]

[]

1

0

1

[ "Mycobacteriales", "freshwater metagenome" ]

[ 818, 1 ]

2

[]

0

true

Family

Alpha-(1->6)-mannopyranosyltransferase A

MptA

4

IPR017824

17,824

Aminodeoxychorismate lyase, class IV

Aminodeoxychorismate_lyase_IV

Family

6,164

false

Aminodeoxychorismate lyase (ADC lyase) converts aminodeoxychorismate to para-aminobenzoate during the process of tetrahydrofolate biosynthesis [ ]. Tetrahydrofolate is an essential precursor for de novo purine biosynthesis. ADC lyase is a pyridoxal-phosphate-binding protein belonging to the class IV aminotransferase fa...

[ "GO:0008696", "GO:0030170", "GO:0046656" ]

[ "4-amino-4-deoxychorismate lyase activity", "pyridoxal phosphate binding", "folic acid biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM", "CDD" ]

[ "TIGR03461", "cd01559" ]

[ "pabC_Proteo", "ADCL_like" ]

[ 4617, 5014 ]

2

[ "EC", "GP", "GP", "GP", "METACYC", "METACYC" ]

[ "4.1.3.38", "GenProp0759", "GenProp1332", "GenProp1727", "PWY-6543", "PWY-8276" ]

[ "EC:4.1.3.38", "GP:GenProp0759", "GP:GenProp1332", "GP:GenProp1727", "METACYC:PWY-6543", "METACYC:PWY-8276" ]

6

[ "1et0", "1i2k", "1i2l", "2y4r", "6bb9", "6q1q", "6q1r", "6q1s" ]

8

[ "PUB00002195", "PUB00151494" ]

[ "1644759", "33950161" ]

[ "Characterization and sequence of Escherichia coli pabC, the gene encoding aminodeoxychorismate lyase, a pyridoxal phosphate-containing enzyme.", "Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis." ]

[ 1992, 2021 ]

2

[ "IPR001544" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Halobacterium", "unclassified sequences" ]

[ 5753, 347, 8, 56 ]

4

[ "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 1, 3, 4 ]

3

true

Family

Aminodeoxychorismate lyase, class IV

Aminodeoxychorismate_lyase_IV

7

IPR017825

17,825

Lycopene cyclase domain

Lycopene_cyclase_dom

Domain

6,251

false

This domain is often repeated twice within the same polypeptide, as is observed in Archaea, Thermus, Sphingobacteria [ ] and Fungi. In the fungal sequences, this tandem domain pair is observed as the N-terminal half of a bifunctional protein [ ], where it has been characterised as a lycopene beta-cyclase and the C-term...

[ "GO:0016872" ]

[ "intramolecular lyase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "NCBIFAM" ]

[ "PF18916", "TIGR03462" ]

[ "Lycopene_cyc", "CarR_dom_SF" ]

[ 4172, 5857 ]

2

[ "EC", "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.5.1.32", "5.5.1.19", "GenProp0758", "PWY-5943", "PWY-5946", "PWY-5947", "PWY-6279", "PWY-7591", "PWY-7938", "PWY-7939", "PWY-7947" ]

[ "EC:2.5.1.32", "EC:5.5.1.19", "GP:GenProp0758", "METACYC:PWY-5943", "METACYC:PWY-5946", "METACYC:PWY-5947", "METACYC:PWY-6279", "METACYC:PWY-7591", "METACYC:PWY-7938", "METACYC:PWY-7939", "METACYC:PWY-7947" ]

11

[]

0

[ "PUB00042980", "PUB00042981", "PUB00088770" ]

[ "16625353", "10951210", "12763034" ]

[ "A carotenoid synthesis gene cluster from Algoriphagus sp. KK10202C with a novel fusion-type lycopene beta-cyclase gene.", "A bifunctional enzyme with lycopene cyclase and phytoene synthase activities is encoded by the carRP gene of Mucor circinelloides.", "Fusion-type lycopene beta-cyclase from a thermoacidoph...

[ 2006, 2000, 2003 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 492, 4533, 961, 265 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Lycopene cyclase domain

Lycopene_cyclase_dom

7

IPR017826

17,826

2,3-oxidosqualene cyclase

2-3-oxidosqualene_cyclase

Family

36

false

2,3-oxidosqualene cyclases are found in Stigmatella aurantiaca producing cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus producing the closely related sterol, lanosterol [ , , ].

[]

0

[ "NCBIFAM" ]

[ "TIGR03463" ]

[ "osq_cycl" ]

[ 36 ]

1

[]

0

[]

0

[ "PUB00042982", "PUB00042983", "PUB00042984" ]

[ "12519197", "17567593", "6780348" ]

[ "Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca.", "Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis.", ...

[ 2003, 2007, 1980 ]

3

[ "IPR018333" ]

[]

1

0

1

[ "Pseudomonadati" ]

[ 36 ]

1

[]

0

true

Family

2,3-oxidosqualene cyclase

2-3-oxidosqualene_cyclase

2

IPR017827

17,827

Hydroxysqualene synthase HpnC

HSQ_synthase_HpnC

Family

3,232

false

In bacteria, squalene (SQ) is an intermediate in the biosynthesis of hopanoids. The genes for hopanoid biosynthesis are typically located on clusters that consist of four highly conserved genes -hpnC, hpnD, hpnE, and hpnF- for conversion of farnesyl diphosphate (FPP) to hopene or related pentacyclic metabolites [ ]. Hp...

[ "GO:0004311" ]

[ "geranylgeranyl diphosphate synthase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03464" ]

[ "HpnC" ]

[ 3232 ]

1

[ "EC", "METACYC" ]

[ "4.2.3.156", "PWY-7072" ]

[ "EC:4.2.3.156", "METACYC:PWY-7072" ]

2

[ "4hd1" ]

1

[ "PUB00042985", "PUB00086647" ]

[ "9714766", "26258173" ]

[ "Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids.", "Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes." ]

[ 1998, 2015 ]

2

[ "IPR044843" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 3190, 4, 38 ]

3

[]

0

true

Family

Hydroxysqualene synthase HpnC

HSQ_synthase_HpnC

8

IPR017828

17,828

Squalene synthase HpnD-like

SQ_synth_HpnD-like

Family

3,572

false

In bacteria, squalene (SQ) is an intermediate in the biosynthesis of hopanoids. The genes for hopanoid biosynthesis are typically located on clusters that consist of four highly conserved genes -hpnC, hpnD, hpnE, and hpnF- for conversion of farnesyl diphosphate (FPP) to hopene or related pentacyclic metabolites [ ]. Hp...

[ "GO:0046905", "GO:0016117" ]

[ "15-cis-phytoene synthase activity", "carotenoid biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03465" ]

[ "HpnD" ]

[ 3572 ]

1

[ "EC" ]

[ "2.5.1" ]

[ "EC:2.5.1" ]

1

[]

0

[ "PUB00042985", "PUB00086647" ]

[ "9714766", "26258173" ]

[ "Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids.", "Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes." ]

[ 1998, 2015 ]

2

[ "IPR044843" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3533, 4, 35 ]

3

[]

0

true

Family

Squalene synthase HpnD-like

SQ_synth_HpnD-like

2

IPR017829

17,829

Hopanoid-associated sugar epimerase

Hopanoid-assoc_sugar_epimerase

Family

1,304

false

The sequences in this entry belong to the superfamily of NAD-dependent epimerases and dehydratases which typically act on nucleotide-sugar substrates. The genes encoding proteins in this entry are generally in the same locus as genes involved in the biosynthesis and elaboration of hopene, the cyclization product of the...

[]

0

[ "NCBIFAM" ]

[ "TIGR03466" ]

[ "HpnA" ]

[ 1304 ]

1

[]

0

[ "3wj7" ]

1

[ "PUB00042985" ]

[ "9714766" ]

[ "Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids." ]

[ 1998 ]

1

[ "IPR051783" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1287, 3, 14 ]

3

[]

0

true

Family

Hopanoid-associated sugar epimerase

Hopanoid-assoc_sugar_epimerase

4