interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR004788 | 4,788 | Ribose 5-phosphate isomerase, type A | Ribose5P_isomerase_type_A | Family | 21,706 | false | false | Ribose 5-phosphate isomerase, also known as phosphoriboisomerase, catalyses the reversible conversion of D-ribose 5-phosphate to D-ribulose 5-phosphate, the first step in the non-oxidative branch of the pentose phosphate pathway [ ]. This reaction enables ribose to be synthesized from sugars, as well as the recycling o... | [
"GO:0004751",
"GO:0009052"
] | [
"ribose-5-phosphate isomerase activity",
"pentose-phosphate shunt, non-oxidative branch"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"PF06026",
"PTHR11934",
"TIGR00021",
"cd01398"
] | [
"Rib_5-P_isom_A",
"",
"rpiA",
"RPI_A"
] | [
21666,
16104,
20162,
20228
] | 4 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.3.1.6",
"GenProp0120",
"GenProp1294",
"GenProp1438",
"PWY-1861",
"PWY-5723",
"PWY-8178",
"R-CEL-71336",
"R-DDI-71336",
"R-HSA-5659996",
"R-HSA-6791461",
"R-HSA-71336",
"R-MMU-71336",
"R-SCE-71336",
"R-SPO-71336"
] | [
"EC:5.3.1.6",
"GP:GenProp0120",
"GP:GenProp1294",
"GP:GenProp1438",
"METACYC:PWY-1861",
"METACYC:PWY-5723",
"METACYC:PWY-8178",
"REACTOME:R-CEL-71336",
"REACTOME:R-DDI-71336",
"REACTOME:R-HSA-5659996",
"REACTOME:R-HSA-6791461",
"REACTOME:R-HSA-71336",
"REACTOME:R-MMU-71336",
"REACTOME:R-SC... | 15 | [
"1ks2",
"1lk5",
"1lk7",
"1lkz",
"1m0s",
"1o8b",
"1uj4",
"1uj5",
"1uj6",
"1xtz",
"2f8m",
"3enq",
"3env",
"3enw",
"3hhe",
"3ixq",
"3kwm",
"3l7o",
"3u7j",
"3uw1",
"4gmk",
"4io1",
"4m8l",
"4nml",
"4x84",
"5uf2",
"6eep",
"6j1k",
"6mc0",
"6zxt",
"7lda"
] | 31 | [
"PUB00020248",
"PUB00028856"
] | [
"12211039",
"12517338"
] | [
"Crystal structure of D-ribose-5-phosphate isomerase (RpiA) from Escherichia coli.",
"Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle."
] | [
2002,
2003
] | 2 | [] | [
"IPR020672"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
927,
13853,
6718,
208
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
17,
1,
1,
2,
1,
3,
1,
2,
10,
3,
1,
1,
15
] | 13 | true | Family | Ribose 5-phosphate isomerase, type A | Ribose 5-phosphate isomerase, type A | Ribose5P_isomerase_type_A | 8 |
IPR004789 | 4,789 | Acetolactate synthase, small subunit | Acetalactate_synth_ssu | Family | 25,903 | false | false | Acetolactate synthases are a group of biosynthetic enzymes apparently found in plants, fungi and bacteria that are capable of de novo synthesis of the branched-chain amino acids [ ]. They can all synthesize acetolactate from pyruvate in the biosynthesis of valine, while some are also capable of synthesizing acetohydrox... | [
"GO:1990610",
"GO:0009082"
] | [
"acetolactate synthase regulator activity",
"branched-chain amino acid biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR30239",
"TIGR00119"
] | [
"",
"acolac_sm"
] | [
24037,
24621
] | 2 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.2.1.6",
"GenProp0162",
"GenProp0163",
"GenProp0164",
"GenProp1342",
"PWY-5101",
"PWY-5103",
"PWY-5104",
"PWY-5938",
"PWY-5939",
"PWY-6389",
"PWY-7111"
] | [
"EC:2.2.1.6",
"GP:GenProp0162",
"GP:GenProp0163",
"GP:GenProp0164",
"GP:GenProp1342",
"METACYC:PWY-5101",
"METACYC:PWY-5103",
"METACYC:PWY-5104",
"METACYC:PWY-5938",
"METACYC:PWY-5939",
"METACYC:PWY-6389",
"METACYC:PWY-7111"
] | 12 | [
"2f1f",
"2fgc",
"2lvw",
"2pc6",
"5ypp",
"5ypw",
"5ypy",
"5yum",
"6lpi",
"6u9d",
"6u9h",
"6vz8",
"6wo1"
] | 13 | [
"PUB00007206",
"PUB00033863"
] | [
"11751050",
"16055369"
] | [
"The ACT domain family.",
"Mechanisms of acetohydroxyacid synthases."
] | [
2001,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
660,
21054,
3717,
472
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
7,
2,
1,
11,
1,
1,
28
] | 7 | true | Family | Acetolactate synthase, small subunit | Acetolactate synthase, small subunit | Acetalactate_synth_ssu | 1 |
IPR004790 | 4,790 | Isocitrate dehydrogenase NADP-dependent | Isocitrate_DH_NADP | Family | 22,176 | false | false | Isocitrate dehydrogenase (IDH) [ , ] is an important enzyme of carbohydrate metabolism which catalyses the oxidative decarboxylation of isocitrate into alpha-ketoglutarate. IDH is either dependent on NAD + ( ) or on NADP + ( ). In eukaryotes there are at least three isozymes of IDH: two are located in the mitochondrial... | [
"GO:0004450",
"GO:0006102"
] | [
"isocitrate dehydrogenase (NADP+) activity",
"isocitrate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PIRSF000108",
"PTHR11822",
"TIGR00127"
] | [
"IDH_NADP",
"",
"nadp_idh_euk"
] | [
14206,
22159,
18749
] | 3 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REAC... | [
"1.1.1.42",
"GenProp0033",
"GenProp1502",
"PWY-5913",
"PWY-6549",
"PWY-6728",
"PWY-6969",
"PWY-7124",
"PWY-7254",
"PWY-7268",
"R-BTA-2151201",
"R-BTA-71403",
"R-BTA-9837999",
"R-BTA-9854311",
"R-DDI-389542",
"R-DDI-6798695",
"R-DDI-9033241",
"R-HSA-2151201",
"R-HSA-2978092",
"R... | [
"EC:1.1.1.42",
"GP:GenProp0033",
"GP:GenProp1502",
"METACYC:PWY-5913",
"METACYC:PWY-6549",
"METACYC:PWY-6728",
"METACYC:PWY-6969",
"METACYC:PWY-7124",
"METACYC:PWY-7254",
"METACYC:PWY-7268",
"REACTOME:R-BTA-2151201",
"REACTOME:R-BTA-71403",
"REACTOME:R-BTA-9837999",
"REACTOME:R-BTA-9854311... | 46 | [
"1lwd",
"1t09",
"1t0l",
"1zor",
"2qfv",
"2qfw",
"2qfx",
"2qfy",
"2uxq",
"2uxr",
"3inm",
"3map",
"3mar",
"3mas",
"3us8",
"4aou",
"4aov",
"4aoy",
"4hcx",
"4i3k",
"4i3l",
"4ja8",
"4kzo",
"4l03",
"4l04",
"4l06",
"4umx",
"4umy",
"4xrx",
"4xs3",
"5de1",
"5h3e"... | 94 | [
"PUB00002669",
"PUB00004691"
] | [
"1939242",
"2682654"
] | [
"NAD(+)-dependent isocitrate dehydrogenase. Cloning, nucleotide sequence, and disruption of the IDH2 gene from Saccharomyces cerevisiae.",
"Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase."
] | [
1991,
1989
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
15,
6437,
15482,
242
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
14,
3,
3,
6,
18,
13,
1,
10,
13,
3,
1,
39
] | 12 | true | Family | Isocitrate dehydrogenase NADP-dependent | Isocitrate dehydrogenase NADP-dependent | Isocitrate_DH_NADP | 8 |
IPR004791 | 4,791 | UvrABC system, subunit C | UvrC | Family | 26,061 | false | false | In Eubacteria and some Archaea, the first steps in nucleotide excision repair are carried out by the coordinated action of the UvrA, UvrB, and UvrC proteins. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged sit... | [
"GO:0009381",
"GO:0006289",
"GO:0009380"
] | [
"excinuclease ABC activity",
"nucleotide-excision repair",
"excinuclease repair complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00203",
"TIGR00194"
] | [
"UvrC",
"uvrC"
] | [
25432,
25399
] | 2 | [
"GP",
"GP"
] | [
"GenProp0114",
"GenProp1190"
] | [
"GP:GenProp0114",
"GP:GenProp1190"
] | 2 | [] | 0 | [
"PUB00057848",
"PUB00088372"
] | [
"12145219",
"29240933"
] | [
"The presence of two UvrB subunits in the UvrAB complex ensures damage detection in both DNA strands.",
"Recruitment of UvrBC complexes to UV-induced damage in the absence of UvrA increases cell survival."
] | [
2002,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
598,
24900,
61,
502
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | UvrABC system, subunit C | UvrABC system, subunit C | UvrC | 4 |
IPR004792 | 4,792 | 3-Dehydro-bile acid delta(4,6)-reductase-like | BaiN-like | Family | 25,030 | false | false | This family of flavoproteins includes 3-dehydro-bile acid delta(4,6)-reductase from Clostridium, which is part of the reductive arm of the bile acid 7-alpha dehydroxylating pathway [ ]. | [] | [] | [] | 0 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR42887",
"TIGR00275"
] | [
"",
""
] | [
25009,
24065
] | 2 | [] | [] | [] | 0 | [
"2gqf",
"2i0z",
"3v76",
"4cnj",
"4cnk"
] | 5 | [
"PUB00090979"
] | [
"29217478"
] | [
"Identification of a gene encoding a flavoprotein involved in bile acid metabolism by the human gut bacterium Clostridium scindens ATCC 35704."
] | [
2018
] | 1 | [] | [
"IPR022460"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
23642,
991,
97,
300
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
1,
5,
9
] | 4 | true | Family | 3-Dehydro-bile acid delta(4,6)-reductase-like | 3-Dehydro-bile acid delta(4,6)-reductase-like | BaiN-like | 7 |
IPR004793 | 4,793 | Desulfoferrodoxin | Desulfoferrodoxin_rbo | Family | 874 | false | false | Desulfoferrodoxin is a non-haem iron protein which contains two types of iron atoms per molecule, a desulfoferrodoxin-like FES(4) site, and an octahedral coordinated high-spin ferrous site with nitrogen/oxygen-containing ligands. The short N-terminal domain contains four conserved Cys for binding of the ferric iron ato... | [
"GO:0005506",
"GO:0019430"
] | [
"iron ion binding",
"removal of superoxide radicals"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00320"
] | [
"dfx_rbo"
] | [
874
] | 1 | [
"EC"
] | [
"1.15.1.2"
] | [
"EC:1.15.1.2"
] | 1 | [
"1dfx",
"1vzg",
"1vzh",
"1vzi",
"2ji1",
"2ji2",
"2ji3"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Cyprideis torosa",
"ecological metagenomes"
] | [
79,
748,
1,
46
] | 4 | [] | [] | 0 | true | Family | Desulfoferrodoxin | Desulfoferrodoxin | Desulfoferrodoxin_rbo | 1 |
IPR004794 | 4,794 | Riboflavin biosynthesis protein RibD | Eubact_RibD | Family | 23,524 | false | false | This entry describes the riboflavin biosynthesis protein (ribD) as found in Escherichia coli. The N-terminal domain includes the conserved zinc-binding site region that is shared by proteins such as cytosine deaminase, mammalian apolipoprotein B mRNA editing protein, blasticidin-S deaminase, and Bacillus subtilis compe... | [
"GO:0008835",
"GO:0009231"
] | [
"diaminohydroxyphosphoribosylaminopyrimidine deaminase activity",
"riboflavin biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF006769",
"TIGR00326"
] | [
"RibD",
"eubact_ribD"
] | [
20793,
23500
] | 2 | [
"EC",
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.1.1.193",
"3.5.4.26",
"GenProp1734",
"PWY-6167",
"PWY-6168",
"PWY-7991"
] | [
"EC:1.1.1.193",
"EC:3.5.4.26",
"GP:GenProp1734",
"METACYC:PWY-6167",
"METACYC:PWY-6168",
"METACYC:PWY-7991"
] | 6 | [
"2b3z",
"2d5n",
"2g6v",
"2hxv",
"2o7p",
"2obc",
"3ex8",
"3zpc",
"3zpg",
"4g3m",
"8dq9",
"8dqb",
"8dqc",
"9no2"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
36,
21652,
1403,
3,
430
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
1,
9,
11
] | 4 | true | Family | Riboflavin biosynthesis protein RibD | Riboflavin biosynthesis protein RibD | Eubact_RibD | 3 |
IPR004796 | 4,796 | Phosphotransferase system, cellobiose-type IIC component | PTS_IIC_cello | Family | 13,378 | false | false | The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system, catalyses the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The phosphotransferase system consists of both the cellobiose-specific and the ... | [
"GO:0008982",
"GO:0009401",
"GO:0016020"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF006351",
"TIGR00359"
] | [
"PTS_EIIC-Cellobiose",
"cello_pts_IIC"
] | [
13340,
2901
] | 2 | [
"GP"
] | [
"GenProp0119"
] | [
"GP:GenProp0119"
] | 1 | [
"3qnq"
] | 1 | [
"PUB00008633",
"PUB00017410",
"PUB00070134",
"PUB00070135"
] | [
"8407820",
"8990303",
"10913117",
"18177310"
] | [
"Cloning and sequencing of a cellobiose phosphotransferase system operon from Bacillus stearothermophilus XL-65-6 and functional expression in Escherichia coli.",
"Identification and characterization of a new beta-glucoside utilization system in Bacillus subtilis.",
"The chitin disaccharide, N,N'-diacetylchitob... | [
1993,
1997,
2000,
2008
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
13358,
4,
16
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Phosphotransferase system, cellobiose-type IIC component | Phosphotransferase system, cellobiose-type IIC component | PTS_IIC_cello | 9 |
IPR004797 | 4,797 | Competence protein ComEC/Rec2 | Competence_ComEC/Rec2 | Family | 11,802 | false | false | Competence is the ability of a cell to take up exogenous DNA from its environment, resulting in transformation. It is widespread among bacteria and is probably an important mechanism for the horizontal transfer of genes. DNA usually becomes available by the death and lysis of other cells. Competent bacteria use compone... | [
"GO:0030420",
"GO:0016020"
] | [
"establishment of competence for transformation",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00361"
] | [
"ComEC_Rec2"
] | [
11802
] | 1 | [
"GP"
] | [
"GenProp0311"
] | [
"GP:GenProp0311"
] | 1 | [] | 0 | [
"PUB00052316",
"PUB00052317"
] | [
"8901420",
"10361283"
] | [
"Who's competent and when: regulation of natural genetic competence in bacteria.",
"Mutational analysis of ComS: evidence for the interaction of ComS and MecA in the regulation of competence development in Bacillus subtilis."
] | [
1996,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
11690,
3,
109
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Competence protein ComEC/Rec2 | Competence protein ComEC/Rec2 | Competence_ComEC/Rec2 | 5 |
IPR004798 | 4,798 | Calcium/proton exchanger CAX-like | CAX-like | Family | 9,711 | false | false | This is a group of calcium/proton exchanger proteins. In Arabidopsis thaliana CAX1 is responsible for maintaining low cytosolic-free Ca2+ concentrations in the plant cells by catalysing pH gradient-energized vacuolar Ca2+ accumulation [ ]. | [
"GO:0015369",
"GO:0006816"
] | [
"calcium:proton antiporter activity",
"calcium ion transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00378"
] | [
"cax"
] | [
9711
] | 1 | [] | [] | [] | 0 | [
"4k1c",
"4kjr",
"4kjs",
"9vsa",
"9vsc",
"9vsd"
] | 6 | [
"PUB00017065"
] | [
"8710949"
] | [
"CAX1, an H+/Ca2+ antiporter from Arabidopsis."
] | [
1996
] | 1 | [
"IPR004713"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
24,
2346,
7331,
10
] | 4 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
34,
2,
9,
1,
1,
35
] | 6 | true | Family | Calcium/proton exchanger CAX-like | Calcium/proton exchanger CAX-like | CAX-like | 9 |
IPR004799 | 4,799 | Periplasmic protein thiol:disulphide oxidoreductase DsbE | Periplasmic_diS_OxRdtase_DsbE | Family | 8,662 | false | false | Periplasmic protein thiol:disulphide oxidoreductase is involved in the biogenesis of c-type cytochromes [ ] as well as in disulphide bond formation in some periplasmic proteins. This group defines the DsbE (also known as CcmG and CycY) subfamily. DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a ... | [
"GO:0015036",
"GO:0017004",
"GO:0030288"
] | [
"disulfide oxidoreductase activity",
"cytochrome complex assembly",
"outer membrane-bounded periplasmic space"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM",
"CDD"
] | [
"TIGR00385",
"cd03010"
] | [
"dsbE",
"TlpA_like_DsbE"
] | [
8463,
7810
] | 2 | [
"GP"
] | [
"GenProp0678"
] | [
"GP:GenProp0678"
] | 1 | [
"1kng",
"1z5y",
"2b1k",
"2b1l",
"2g0f",
"3k8n",
"3kh7",
"3kh9"
] | 8 | [
"PUB00026776",
"PUB00080820",
"PUB00080821",
"PUB00080822",
"PUB00080823"
] | [
"12121652",
"12196152",
"11843181",
"11256948",
"9537397"
] | [
"Structure of CcmG/DsbE at 1.14 A resolution: high-fidelity reducing activity in an indiscriminately oxidizing environment.",
"Cytochrome c maturation: a complex pathway for a simple task?",
"Structural and redox properties of the leaderless DsbE (CcmG) protein: both active-site cysteines of the reduced form ar... | [
2002,
2002,
2001,
2001,
1998
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
8533,
9,
120
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Periplasmic protein thiol:disulphide oxidoreductase DsbE | Periplasmic protein thiol:disulphide oxidoreductase DsbE | Periplasmic_diS_OxRdtase_DsbE | 7 |
IPR004800 | 4,800 | Phosphosugar isomerase, KdsD/KpsF-type | KdsD/KpsF-type | Family | 15,304 | false | false | This is a family of closely related proteins with the phosphosugar-binding domain SIS (Sugar ISomerase) followed by two copies of the CBS (named after Cystathionine Beta Synthase) domain. The group includes GutQ, a protein of the glucitol operon [ , ] and KpsF, a virulence factor involved in capsular polysialic acid bi... | [
"GO:0016853",
"GO:0005975"
] | [
"isomerase activity",
"carbohydrate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF004692",
"TIGR00393"
] | [
"KdsD_KpsF",
"kpsF"
] | [
14877,
15288
] | 2 | [
"EC",
"METACYC",
"METACYC"
] | [
"5.3.1.13",
"PWY-1269",
"PWY-7674"
] | [
"EC:5.3.1.13",
"METACYC:PWY-1269",
"METACYC:PWY-7674"
] | 3 | [
"2xhz"
] | 1 | [
"PUB00057351",
"PUB00057352",
"PUB00057353"
] | [
"16199563",
"2134185",
"16390329"
] | [
"Identification of GutQ from Escherichia coli as a D-arabinose 5-phosphate isomerase.",
"Nucleotide sequence and expression of the gutQ gene within the glucitol operon of Escherichia coli.",
"Characterization of Escherichia coli D-arabinose 5-phosphate isomerase encoded by kpsF: implications for group 2 capsule... | [
2005,
1990,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"Tetraselmis virus 1",
"unclassified sequences"
] | [
14409,
673,
9,
1,
212
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
2,
2,
6
] | 4 | true | Family | Phosphosugar isomerase, KdsD/KpsF-type | Phosphosugar isomerase, KdsD/KpsF-type | KdsD/KpsF-type | 5 |
IPR004801 | 4,801 | Phosphotransferase system, lactose-specific IIC component | LacE | Domain | 676 | false | false | This family of proteins models the IIC domain of the phosphotransferase system (PTS) for lactose. The IIC domain catalyzes the transfer of a phosphoryl group from the IIB domain to lactose. When the IIC component and IIB components are in the same polypeptide chain they are designated IIBC. | [
"GO:0008982",
"GO:0022869",
"GO:0016020"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity",
"membrane"
] | [
"molecular_function",
"molecular_function",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00394"
] | [
"lac_pts_IIC"
] | [
676
] | 1 | [
"EC",
"GP"
] | [
"2.7.1.207",
"GenProp0119"
] | [
"EC:2.7.1.207",
"GP:GenProp0119"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR004501"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"human gut metagenome"
] | [
675,
1
] | 2 | [] | [] | 0 | true | Domain | Phosphotransferase system, lactose-specific IIC component | Phosphotransferase system, lactose-specific IIC component | LacE | 3 |
IPR004802 | 4,802 | tRNA pseudouridine synthase B family | tRNA_PsdUridine_synth_B_fam | Family | 6,330 | false | false | This family, found in archaea and eukaryotes, includes the only archaeal proteins markedly similar to bacterial TruB, the tRNA pseudouridine 55 synthase. However, among two related yeast proteins, the archaeal set matches yeast YLR175w far better than YNL292w. The first, termed centromere/microtubule binding protein 5 ... | [
"GO:0006396"
] | [
"RNA processing"
] | [
"biological_process"
] | 1 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR23127",
"TIGR00425"
] | [
"",
"CBF5"
] | [
6328,
5789
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.4.99.25",
"R-CEL-171319",
"R-DDI-171319",
"R-DME-171319",
"R-GGA-417076",
"R-HSA-171319",
"R-HSA-6790901",
"R-MMU-171319",
"R-RNO-171319",
"R-SCE-171319",
"R-SPO-171319"
] | [
"EC:5.4.99.25",
"REACTOME:R-CEL-171319",
"REACTOME:R-DDI-171319",
"REACTOME:R-DME-171319",
"REACTOME:R-GGA-417076",
"REACTOME:R-HSA-171319",
"REACTOME:R-HSA-6790901",
"REACTOME:R-MMU-171319",
"REACTOME:R-RNO-171319",
"REACTOME:R-SCE-171319",
"REACTOME:R-SPO-171319"
] | 11 | [
"2apo",
"2aus",
"2ey4",
"2hvy",
"2rfk",
"3hax",
"3hay",
"3hjw",
"3hjy",
"3lwo",
"3lwp",
"3lwq",
"3lwr",
"3lwv",
"3mqk",
"3u28",
"3uai",
"3zv0",
"7bgb",
"7trc",
"7v9a",
"8oue",
"8ouf",
"9g25",
"9g28",
"9qb2",
"9qb3"
] | 27 | [
"PUB00001931",
"PUB00027823",
"PUB00053437",
"PUB00053438",
"PUB00060409",
"PUB00060410",
"PUB00060411",
"PUB00060413",
"PUB00060414",
"PUB00060415",
"PUB00060416",
"PUB00060417"
] | [
"9472021",
"8336724",
"10523634",
"9848653",
"16601202",
"12437656",
"15304085",
"18802941",
"17417794",
"10591218",
"10364516",
"21820037"
] | [
"The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase.",
"An essential yeast protein, CBF5p, binds in vitro to centromeres and microtubules.",
"Point mutations in yeast CBF5 can abolish in vivo pseudouridylation of rRNA.",
"Cbf5p, a potential pseudouridine synthase, and Nhp2p, a putat... | [
1998,
1993,
1999,
1998,
2006,
2002,
2004,
2009,
2008,
1999,
1999,
2011
] | 12 | [] | [
"IPR026326"
] | 0 | 1 | 0 | [
"Archaea",
"Candidatus Rhodobacter oscarellae",
"Eukaryota",
"unclassified sequences"
] | [
992,
1,
5293,
44
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
2,
5,
15,
7,
1,
13,
5,
1,
1,
6
] | 12 | true | Family | tRNA pseudouridine synthase B family | tRNA pseudouridine synthase B family | tRNA_PsdUridine_synth_B_fam | 4 |
IPR004803 | 4,803 | tRNA-guanine transglycosylase | TGT | Family | 25,329 | false | false | Queuine is a hypermodified base that occurs in the wobble position of the anticodon of tRNAs Asp, Asn, His and Tyr. Queuine is incorporated into tRNA via a base exchange reaction with guanine catalysed by queuine tRNA-ribosyltransferase (also known as tRNA-guanine transglycosylase). In eukaryotes, queuine is directly e... | [
"GO:0008479"
] | [
"tRNA-guanosine(34) queuine transglycosylase activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00168",
"TIGR00430"
] | [
"Q_tRNA_Tgt",
"Q_tRNA_tgt"
] | [
24398,
25167
] | 2 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"REACTOME"
] | [
"2.4.2.29",
"GenProp0677",
"GenProp1400",
"PWY-6700",
"PWY-8106",
"R-HSA-6782315"
] | [
"EC:2.4.2.29",
"GP:GenProp0677",
"GP:GenProp1400",
"METACYC:PWY-6700",
"METACYC:PWY-8106",
"REACTOME:R-HSA-6782315"
] | 6 | [
"1efz",
"1enu",
"1f3e",
"1k4g",
"1k4h",
"1n2v",
"1ozm",
"1ozq",
"1p0b",
"1p0d",
"1p0e",
"1pud",
"1pxg",
"1q2r",
"1q2s",
"1q4w",
"1q63",
"1q65",
"1q66",
"1r5y",
"1s38",
"1s39",
"1wkd",
"1wke",
"1wkf",
"1y5v",
"1y5w",
"1y5x",
"2ash",
"2bbf",
"2nqz",
"2nso"... | 186 | [
"PUB00046129",
"PUB00046130",
"PUB00046131",
"PUB00082327",
"PUB00082328"
] | [
"12697167",
"16401090",
"10862614",
"11255023",
"20354154"
] | [
"Biosynthesis of the 7-deazaguanosine hypermodified nucleosides of transfer RNA.",
"Role of aspartate 143 in Escherichia coli tRNA-guanine transglycosylase: alteration of heterocyclic substrate specificity.",
"Hypermodification of tRNA in Thermophilic archaea. Cloning, overexpression, and characterization of tR... | [
2003,
2006,
2000,
2001,
2010
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
37,
21360,
3472,
7,
453
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces po... | [
1,
1,
1,
1,
2,
1,
2,
3,
3,
1,
9
] | 11 | true | Family | tRNA-guanine transglycosylase | tRNA-guanine transglycosylase | TGT | 2 |
IPR004804 | 4,804 | tRNA-guanine(15) transglycosylase | TgtA | Family | 917 | false | false | This tRNA-guanine transglycosylase (tgt) from archaea differs from the tgt of E. coli and other Bacteria in the site of action and the modification that results. It exchanges 7-cyano-7-deazaguanine (preQ0) with guanine at position 15 of archaeal tRNA; this nucleotide is subsequently converted to archaeosine, found excl... | [
"GO:0016763",
"GO:0006400"
] | [
"pentosyltransferase activity",
"tRNA modification"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01634",
"TIGR00432"
] | [
"TgtA_arch",
"arcsn_tRNA_tgt"
] | [
863,
917
] | 2 | [
"EC",
"GP",
"METACYC",
"METACYC"
] | [
"2.4.2.48",
"GenProp1735",
"PWY-6711",
"PWY-7923"
] | [
"EC:2.4.2.48",
"GP:GenProp1735",
"METACYC:PWY-6711",
"METACYC:PWY-7923"
] | 4 | [
"1iq8",
"1it7",
"1it8",
"1j2b"
] | 4 | [
"PUB00005802"
] | [
"9389475"
] | [
"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Geodia barretti",
"ecological metagenomes"
] | [
887,
1,
29
] | 3 | [] | [] | 0 | true | Family | tRNA-guanine(15) transglycosylase | tRNA-guanine(15) transglycosylase | TgtA | 8 |
IPR004805 | 4,805 | Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC | DnaE2/DnaE/PolC | Family | 52,704 | false | false | All proteins in this family for which functions are known are DNA polymerases. The group includes the error-prone DNA polymerase (DnaE2), involved in damage-induced mutagenesis and translesion synthesis (TLS), DNA polymerase III PolC-type, and the alpha subunit of DNA polymerase III (DnaE) ( ). DNA polymerase III is a ... | [
"GO:0008408",
"GO:0006260"
] | [
"3'-5' exonuclease activity",
"DNA replication"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR32294",
"TIGR00594"
] | [
"",
"polc"
] | [
52703,
41276
] | 2 | [
"EC",
"GP",
"GP"
] | [
"2.7.7.7",
"GenProp0263",
"GenProp1155"
] | [
"EC:2.7.7.7",
"GP:GenProp0263",
"GP:GenProp1155"
] | 3 | [
"2hnh",
"2hpi",
"2hpm",
"2hqa",
"3e0d",
"3f2b",
"3f2c",
"3f2d",
"4gx8",
"4gx9",
"4iqj",
"4jom",
"5fku",
"5fkv",
"5fkw",
"5lew",
"5m1s",
"7pu7",
"9qpc",
"9qrl",
"9qrn"
] | 21 | [
"PUB00150972"
] | [
"24106089"
] | [
"Comprehensive analysis of DNA polymerase III α subunits and their homologs in bacterial genomes."
] | [
2014
] | 1 | [] | [
"IPR006308",
"IPR023073"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
5,
50236,
246,
560,
1657
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC | Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC | DnaE2/DnaE/PolC | 1 |
IPR004806 | 4,806 | UV excision repair protein Rad23 | Rad23 | Family | 7,628 | false | false | All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. Rad23 contains a ubiquitin-like domain that interacts with catalytically active proteasomes and two ubiquitin (Ub)-associated (UBA) sequences ... | [
"GO:0006289"
] | [
"nucleotide-excision repair"
] | [
"biological_process"
] | 1 | [
"PRINTS",
"NCBIFAM"
] | [
"PR01839",
"TIGR00601"
] | [
"RAD23PROTEIN",
"rad23"
] | [
7321,
6408
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-532668",
"R-BTA-5689877",
"R-BTA-5696394",
"R-BTA-5696395",
"R-DDI-5696394",
"R-DDI-5696395",
"R-HSA-532668",
"R-HSA-5689877",
"R-HSA-5696394",
"R-HSA-5696395",
"R-MMU-532668",
"R-MMU-5689877",
"R-MMU-5696394",
"R-MMU-5696395",
"R-RNO-532668",
"R-RNO-5689877",
"R-RNO-5696394",... | [
"REACTOME:R-BTA-532668",
"REACTOME:R-BTA-5689877",
"REACTOME:R-BTA-5696394",
"REACTOME:R-BTA-5696395",
"REACTOME:R-DDI-5696394",
"REACTOME:R-DDI-5696395",
"REACTOME:R-HSA-532668",
"REACTOME:R-HSA-5689877",
"REACTOME:R-HSA-5696394",
"REACTOME:R-HSA-5696395",
"REACTOME:R-MMU-532668",
"REACTOME:R... | 19 | [
"1dv0",
"1f4i",
"1oqy",
"1qze",
"1tp4",
"2qsf",
"2qsg",
"2qsh",
"4yir",
"6cfi",
"6ubf",
"6uin",
"6xqi",
"6xqj",
"8ebs",
"8ebv",
"8ebw"
] | 17 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Klosneuvirus KNV1",
"bird metagenome"
] | [
7626,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
25,
1,
6,
4,
10,
10,
1,
11,
10,
1,
1,
43
] | 12 | true | Family | UV excision repair protein Rad23 | UV excision repair protein Rad23 | Rad23 | 7 |
IPR004807 | 4,807 | UvrABC system, subunit B | UvrB | Family | 28,989 | false | false | This entry represents the UvrB subunit. UvrB shares structural similarity with helicases and have ATPase activity [ , ]. In Eubacteria and some Archaea, the first steps in nucleotide excision repair are carried out by the coordinated action of the UvrA, UvrB, and UvrC proteins. A damage recognition complex composed of ... | [
"GO:0003677",
"GO:0005524",
"GO:0016887",
"GO:0006289",
"GO:0009380"
] | [
"DNA binding",
"ATP binding",
"ATP hydrolysis activity",
"nucleotide-excision repair",
"excinuclease repair complex"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 5 | [
"HAMAP",
"NCBIFAM",
"PANTHER",
"NCBIFAM"
] | [
"MF_00204",
"NF003673",
"PTHR24029",
"TIGR00631"
] | [
"UvrB",
"PRK05298.1",
"",
"uvrb"
] | [
25677,
26353,
28988,
26268
] | 4 | [
"GP",
"GP",
"GP"
] | [
"GenProp0114",
"GenProp1109",
"GenProp1190"
] | [
"GP:GenProp0114",
"GP:GenProp1109",
"GP:GenProp1190"
] | 3 | [
"1c4o",
"1d2m",
"1d9x",
"1d9z",
"1t5l",
"2b2n",
"2d7d",
"2fdc",
"2nmv",
"3fpn",
"3hjh",
"3uwx",
"3v4r",
"4dfc",
"6o8e",
"6o8f",
"6o8g",
"6o8h",
"7egt",
"9ga3",
"9ga4"
] | 21 | [
"PUB00057848",
"PUB00057850",
"PUB00088371"
] | [
"12145219",
"11421287",
"10946234"
] | [
"The presence of two UvrB subunits in the UvrAB complex ensures damage detection in both DNA strands.",
"Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair.",
"The nucleotide excision repair protein UvrB, a helicase-like enzyme with a catch."
] | [
2002,
2001,
2000
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
626,
27125,
246,
2,
990
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | UvrABC system, subunit B | UvrABC system, subunit B | UvrB | 1 |
IPR004808 | 4,808 | AP endonuclease 1 | AP_endonuc_1 | Family | 48,462 | false | false | AP endonucleases can be classified into two families based on sequence similarity. This family contains members of AP endonuclease family 1. They are endonucleases that remove the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction [ , ]. The proteins contain g... | [
"GO:0004518",
"GO:0006281"
] | [
"nuclease activity",
"DNA repair"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROFILE",
"PANTHER",
"NCBIFAM"
] | [
"PS51435",
"PTHR22748",
"TIGR00633"
] | [
"AP_NUCLEASE_F1_4",
"",
"xth"
] | [
44240,
23741,
41256
] | 3 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.1.11.2",
"R-DDI-110357",
"R-DDI-110362",
"R-DDI-110373",
"R-DDI-5651801",
"R-DDI-73930",
"R-DDI-73933",
"R-DME-110357",
"R-DME-110373",
"R-DME-5651801",
"R-DME-73933",
"R-DRE-110357",
"R-DRE-110362",
"R-DRE-110373",
"R-DRE-73930",
"R-DRE-73933",
"R-HSA-110357",
"R-HSA-110362",
... | [
"EC:3.1.11.2",
"REACTOME:R-DDI-110357",
"REACTOME:R-DDI-110362",
"REACTOME:R-DDI-110373",
"REACTOME:R-DDI-5651801",
"REACTOME:R-DDI-73930",
"REACTOME:R-DDI-73933",
"REACTOME:R-DME-110357",
"REACTOME:R-DME-110373",
"REACTOME:R-DME-5651801",
"REACTOME:R-DME-73933",
"REACTOME:R-DRE-110357",
"RE... | 38 | [
"1ako",
"1bix",
"1de8",
"1de9",
"1dew",
"1e9n",
"1hd7",
"1vyb",
"2isi",
"2j63",
"2jc4",
"2jc5",
"2myi",
"2o3c",
"2o3h",
"2v0r",
"2v0s",
"2voa",
"3fzi",
"3g00",
"3g0a",
"3g0r",
"3g1k",
"3g2c",
"3g2d",
"3g38",
"3g3c",
"3g3y",
"3g4t",
"3g8v",
"3g91",
"3ga6"... | 125 | [
"PUB00004207",
"PUB00094227"
] | [
"7885481",
"25569774"
] | [
"Structure and function of the multifunctional DNA-repair enzyme exonuclease III.",
"An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis [corrected]."
] | [
1995,
2015
] | 2 | [] | [
"IPR037493"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
307,
35206,
12368,
9,
572
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
25,
2,
10,
2,
1,
20,
10,
3,
14,
17,
1,
1,
34
] | 13 | true | Family | AP endonuclease 1 | AP endonuclease 1 | AP_endonuc_1 | 4 |
IPR004809 | 4,809 | Glutamine synthetase type I | Gln_synth_I | Family | 24,302 | false | false | Glutamine synthetase type I (or glutamate-ammonia ligase) has a dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. Escherichia coli, Synechocystis sp. (strain PCC 6803), Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldar... | [
"GO:0004356"
] | [
"glutamine synthetase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00653"
] | [
"GlnA"
] | [
24302
] | 1 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"6.3.1.2",
"GenProp1615",
"PWY-6963",
"PWY-6964",
"PWY-8291",
"PWY-8294"
] | [
"EC:6.3.1.2",
"GP:GenProp1615",
"METACYC:PWY-6963",
"METACYC:PWY-6964",
"METACYC:PWY-8291",
"METACYC:PWY-8294"
] | 6 | [
"1f1h",
"1f52",
"1fpy",
"1hto",
"1htq",
"1lgr",
"2bvc",
"2gls",
"2lgs",
"2wgs",
"2whi",
"3ng0",
"3zxr",
"3zxv",
"4acf",
"4lnf",
"4lni",
"4lnk",
"4lnn",
"4lno",
"4s0r",
"4s17",
"4xyc",
"5ldf",
"5zli",
"5zlp",
"7tdp",
"7tdv",
"7ten",
"7tf6",
"7tf7",
"7tf9"... | 57 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
907,
22993,
86,
316
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Glutamine synthetase type I | Glutamine synthetase type I | Gln_synth_I | 3 |
IPR004810 | 4,810 | Formyltetrahydrofolate deformylase | PurU | Family | 21,535 | false | false | An Escherichia coli gene designated purU has been identified and characterised. The gene codes for a 280-amino-acid protein, PurU ( , ). PurU is an enzyme that catalyses the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to FH4 and formate [ , ]. 10-formyltetrahydrofolate + H(2)O = formate +tetrahydrofolate Formy... | [
"GO:0008864",
"GO:0006189"
] | [
"formyltetrahydrofolate deformylase activity",
"'de novo' IMP biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM",
"PRINTS",
"PANTHER",
"NCBIFAM"
] | [
"MF_01927",
"NF004684",
"PR01575",
"PTHR42706",
"TIGR00655"
] | [
"PurU",
"PRK06027.1",
"FFH4HYDRLASE",
"",
"PurU"
] | [
19147,
20619,
21293,
21360,
19217
] | 5 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.5.1.10",
"PWY-2201",
"PWY-5497",
"PWY-7909"
] | [
"EC:3.5.1.10",
"METACYC:PWY-2201",
"METACYC:PWY-5497",
"METACYC:PWY-7909"
] | 4 | [
"3lou",
"3n0v",
"3nrb",
"3o1l",
"3obi",
"3w7b"
] | 6 | [
"PUB00007025",
"PUB00007026",
"PUB00099957"
] | [
"7868604",
"8226647",
"18628352"
] | [
"Formyltetrahydrofolate hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli.",
"purU, a source of formate for purT-dependent phosphoribosyl-N-formylglycinamide synthesis.",
"Arabidopsis 10-formyl tetrahydrofolate deformyl... | [
1995,
1993,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
386,
18899,
2011,
239
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
1,
1,
4,
5
] | 5 | true | Family | Formyltetrahydrofolate deformylase | Formyltetrahydrofolate deformylase | PurU | 3 |
IPR004811 | 4,811 | RelA/SpoT family | RelA/Spo_fam | Family | 30,842 | false | false | RelA/SpoT-homologue proteins (RHS) mediate the stringent response in bacteria which enables its metabolic adaptation under stress conditions. These enzymes synthesize the second messenger (p)ppGpp, a small molecule also known as 'alarmone', which is a regulatory metabolite of the stringent response, characterised by gr... | [
"GO:0015969"
] | [
"guanosine tetraphosphate metabolic process"
] | [
"biological_process"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00691"
] | [
"spoT_relA"
] | [
30842
] | 1 | [
"EC",
"GP"
] | [
"2.7.6.5",
"GenProp1755"
] | [
"EC:2.7.6.5",
"GP:GenProp1755"
] | 2 | [
"1vj7",
"5iqr",
"5kps",
"5kpv",
"5kpw",
"5kpx",
"5l3p",
"5xnx",
"6yxa",
"7oiw",
"8acu",
"8fr8"
] | 12 | [
"PUB00055016",
"PUB00059269",
"PUB00059271",
"PUB00059272",
"PUB00095792",
"PUB00098863",
"PUB00098872"
] | [
"19460094",
"15866041",
"9383190",
"11545276",
"27434674",
"18996989",
"32937119"
] | [
"Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress.",
"ppGpp: a global regulator in Escherichia coli.",
"Cloning and characterization of a relA/spoT homologue from Bacillus subtilis.",
"Comparative genomics and evolution of genes encoding bacterial (p)ppGpp synthetas... | [
2009,
2005,
1997,
2001,
2016,
2009,
2020
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
30252,
1,
97,
3,
489
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | RelA/SpoT family | RelA/SpoT family | RelA/Spo_fam | 5 |
IPR004812 | 4,812 | Drug resistance transporter Bcr/CmlA subfamily | Efflux_drug-R_Bcr/CmlA | Family | 30,006 | false | false | The drug resistance transporter Bcr/CflA proteins are predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in Escherichia coli [ ], Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium [ ], and CmlA (chloramphenicol resistance) ... | [
"GO:0042910",
"GO:1990961",
"GO:0016020"
] | [
"xenobiotic transmembrane transporter activity",
"xenobiotic detoxification by transmembrane export across the plasma membrane",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00710"
] | [
"efflux_Bcr_CflA"
] | [
30006
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00017556",
"PUB00070781",
"PUB00070782"
] | [
"8486276",
"1648560",
"15980376"
] | [
"Cloning and sequence analysis of an Escherichia coli gene conferring bicyclomycin resistance.",
"Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn1696: similarity of the product to transmembrane transport proteins.",
"Structural and functional study of the ph... | [
1993,
1991,
2005
] | 3 | [
"IPR011701"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanomicrobia",
"Punavirus P1",
"unclassified sequences"
] | [
29809,
17,
61,
1,
118
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Drug resistance transporter Bcr/CmlA subfamily | Drug resistance transporter Bcr/CmlA subfamily | Efflux_drug-R_Bcr/CmlA | 3 |
IPR004813 | 4,813 | Oligopeptide transporter, OPT superfamily | OPT | Family | 38,177 | false | false | The transporter OPT family are transporters of small oligopeptides, demonstrated experimentally in three different species of yeast. OPT1 is not a member of the ABC or PTR membrane transport families [ ]. | [
"GO:0035673"
] | [
"oligopeptide transmembrane transporter activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"NCBIFAM"
] | [
"PF03169",
"TIGR00728"
] | [
"OPT",
"OPT_sfam"
] | [
38177,
32334
] | 2 | [] | [] | [] | 0 | [
"7wsr",
"7wst",
"7wsu"
] | 3 | [
"PUB00007024"
] | [
"9043116"
] | [
"An oligopeptide transport gene from Candida albicans."
] | [
1997
] | 1 | [] | [
"IPR004648",
"IPR045035"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ct9mC1",
"metagenomes"
] | [
150,
6207,
31680,
1,
139
] | 5 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
79,
11,
84,
3,
3,
161
] | 6 | true | Family | Oligopeptide transporter, OPT superfamily | Oligopeptide transporter, OPT superfamily | OPT | 1 |
IPR004815 | 4,815 | Lon protease, bacterial/eukaryotic-type | Lon_bac/euk-typ | Family | 32,091 | false | false | Lon protease belongs to the S16 peptidase family and is an ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins, as well as certain short-lived regulatory proteins. It is required for cellular homeostasis and for survival from DNA damage and developmental changes induced... | [
"GO:0004176",
"GO:0005524",
"GO:0006508"
] | [
"ATP-dependent peptidase activity",
"ATP binding",
"proteolysis"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF001174",
"TIGR00763"
] | [
"Lon_proteas",
"lon"
] | [
27936,
31259
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.21.53",
"R-BTA-9033241",
"R-CEL-9033241",
"R-CEL-9837999",
"R-DDI-9837999",
"R-DME-9837999",
"R-HSA-390471",
"R-HSA-9033241",
"R-HSA-9837999",
"R-HSA-9841251",
"R-MMU-9033241",
"R-MMU-9837999",
"R-RNO-9033241",
"R-RNO-9837999",
"R-SCE-9837999",
"R-SPO-9837999"
] | [
"EC:3.4.21.53",
"REACTOME:R-BTA-9033241",
"REACTOME:R-CEL-9033241",
"REACTOME:R-CEL-9837999",
"REACTOME:R-DDI-9837999",
"REACTOME:R-DME-9837999",
"REACTOME:R-HSA-390471",
"REACTOME:R-HSA-9033241",
"REACTOME:R-HSA-9837999",
"REACTOME:R-HSA-9841251",
"REACTOME:R-MMU-9033241",
"REACTOME:R-MMU-983... | 16 | [
"3m6a",
"4ypl",
"6on2",
"6u5z",
"6v11",
"6wqh",
"7fd4",
"7fd5",
"7fid",
"7fie",
"7fiz",
"7krz",
"7ksl",
"7ksm",
"7nfy",
"7ng4",
"7ng5",
"7ngc",
"7ngf",
"7ngl",
"7ngp",
"7ngq",
"7oxo",
"7p09",
"7p0b",
"7p0m",
"7p6u",
"7sxo",
"7yph",
"7ypi",
"7ypj",
"7ypk"... | 49 | [
"PUB00000452",
"PUB00001838",
"PUB00002455",
"PUB00002806",
"PUB00002870",
"PUB00004808",
"PUB00011879",
"PUB00062804",
"PUB00062807"
] | [
"9425059",
"8294008",
"3042779",
"8226758",
"8276800",
"8248235",
"9620272",
"10672180",
"17216028"
] | [
"The lon protease from Mycobacterium smegmatis: molecular cloning, sequence analysis, functional expression, and enzymatic characterization.",
"Controlled high-level expression of the lon gene of Escherichia coli allows overproduction of Lon protease.",
"Sequence of the lon gene in Escherichia coli. A heat-shoc... | [
1998,
1993,
1988,
1993,
1994,
1993,
1998,
2000,
2006
] | 9 | [
"IPR027065"
] | [
"IPR027501",
"IPR027503",
"IPR027543"
] | 1 | 3 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"unclassified sequences"
] | [
23225,
8489,
81,
5,
291
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
18,
2,
2,
2,
1,
11,
4,
2,
6,
6,
1,
1,
46
] | 13 | true | Family | Lon protease, bacterial/eukaryotic-type | Lon protease, bacterial/eukaryotic-type | Lon_bac/euk-typ | 2 |
IPR004816 | 4,816 | Hydroxymethylglutaryl-CoA reductase, metazoan | HMG_CoA_Rdtase_metazoan | Family | 1,831 | false | false | There are two distinct classes of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase enzymes: class I consists of eukaryotic and most archaeal enzymes ( ), while class II consists of prokaryotic enzymes ( ) [ , ]. Class I HMG-CoA reductases catalyse the NADP-dependent synthesis of mevalonate from 3-hydroxy-3-methylgl... | [
"GO:0004420",
"GO:0050661",
"GO:0008299",
"GO:0005789"
] | [
"hydroxymethylglutaryl-CoA reductase (NADPH) activity",
"NADP binding",
"isoprenoid biosynthetic process",
"endoplasmic reticulum membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"NCBIFAM"
] | [
"TIGR00920"
] | [
"2A060605"
] | [
1831
] | 1 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.1.1.34",
"GenProp1432",
"PWY-6174",
"PWY-7391",
"PWY-7524",
"PWY-8125",
"PWY-922",
"R-BTA-191273",
"R-DME-191273",
"R-HSA-191273",
"R-HSA-1989781",
"R-HSA-2426168",
"R-HSA-9619665",
"R-MMU-191273",
"R-RNO-191273"
] | [
"EC:1.1.1.34",
"GP:GenProp1432",
"METACYC:PWY-6174",
"METACYC:PWY-7391",
"METACYC:PWY-7524",
"METACYC:PWY-8125",
"METACYC:PWY-922",
"REACTOME:R-BTA-191273",
"REACTOME:R-DME-191273",
"REACTOME:R-HSA-191273",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-2426168",
"REACTOME:R-HSA-9619665",
"REAC... | 15 | [
"1dq8",
"1dq9",
"1dqa",
"1hw8",
"1hw9",
"1hwi",
"1hwj",
"1hwk",
"1hwl",
"2q1l",
"2q6b",
"2q6c",
"2r4f",
"3bgl",
"3cct",
"3ccw",
"3ccz",
"3cd0",
"3cd5",
"3cd7",
"3cda",
"3cdb",
"8pkn",
"8s6b"
] | 24 | [
"PUB00003654",
"PUB00019711",
"PUB00036052",
"PUB00036053",
"PUB00036054"
] | [
"3065625",
"15535874",
"10068515",
"10600463",
"15028676"
] | [
"Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis.",
"The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases.",
"Sequence comparisons reveal two classes of 3-hydroxy-3-methylglutaryl coenzyme ... | [
1988,
2004,
1999,
1999,
2004
] | 5 | [
"IPR004554"
] | [] | 1 | 0 | 1 | [
"Opisthokonta"
] | [
1831
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
3,
4,
3,
7
] | 5 | true | Family | Hydroxymethylglutaryl-CoA reductase, metazoan | Hydroxymethylglutaryl-CoA reductase, metazoan | HMG_CoA_Rdtase_metazoan | 2 |
IPR004817 | 4,817 | Sodium/potassium/calcium exchanger 1 | SLC24A1 | Family | 446 | false | false | Sodium/potassium/calcium exchanger 1 (NCKX1), also known as SLC24A1, is an integral membrane protein that transports one calcium and one potassium ion in exchange for four sodium ions. It is expressed only in retinal rod photoreceptors. NCKX1 controls the calcium concentration of outer segments during light and darknes... | [
"GO:0008273",
"GO:0006816",
"GO:0007601",
"GO:0016020"
] | [
"calcium, potassium:sodium antiporter activity",
"calcium ion transport",
"visual perception",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"NCBIFAM"
] | [
"TIGR00927"
] | [
"2A1904"
] | [
446
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2485179",
"R-HSA-425561",
"R-HSA-5619077",
"R-MMU-425561",
"R-RNO-425561"
] | [
"REACTOME:R-HSA-2485179",
"REACTOME:R-HSA-425561",
"REACTOME:R-HSA-5619077",
"REACTOME:R-MMU-425561",
"REACTOME:R-RNO-425561"
] | 5 | [] | 0 | [
"PUB00072028",
"PUB00072029",
"PUB00072071"
] | [
"12899631",
"14770312",
"8556771"
] | [
"Signal sequence cleavage and plasma membrane targeting of the retinal rod NCKX1 and cone NCKX2 Na+/Ca2+ - K+ exchangers.",
"The SLC24 Na+/Ca2+-K+ exchanger family: vision and beyond.",
"Calcium homeostasis in vertebrate retinal rod outer segments."
] | [
2003,
2004,
1995
] | 3 | [
"IPR004481"
] | [] | 1 | 0 | 1 | [
"Theria"
] | [
446
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
6
] | 3 | true | Family | Sodium/potassium/calcium exchanger 1 | Sodium/potassium/calcium exchanger 1 | SLC24A1 | 8 |
IPR004821 | 4,821 | Cytidyltransferase-like domain | Cyt_trans-like | Domain | 125,292 | false | false | Protein families that contain at least one copy of this domain include citrate lyase ligase, pantoate-beta-alanine ligase, glycerol-3-phosphate cytidyltransferase [ ], ADP-heptose synthase, phosphocholine cytidylyltransferase, lipopolysaccharide core biosynthesis protein KdtB, the bifunctional protein NadR, archaeal FA... | [
"GO:0003824",
"GO:0009058"
] | [
"catalytic activity",
"biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"NCBIFAM"
] | [
"PF01467",
"TIGR00125"
] | [
"CTP_transf_like",
"cyt_tran_rel"
] | [
102765,
106413
] | 2 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"R... | [
"2.7.7",
"GenProp0724",
"GenProp1239",
"GenProp1296",
"GenProp1351",
"GenProp1658",
"R-BTA-196807",
"R-CEL-1483191",
"R-CEL-196807",
"R-DDI-1483213",
"R-DME-196807",
"R-DRE-196807",
"R-HSA-1483191",
"R-HSA-1483213",
"R-HSA-196783",
"R-HSA-196807",
"R-MMU-1483191",
"R-MMU-1483213",
... | [
"EC:2.7.7",
"GP:GenProp0724",
"GP:GenProp1239",
"GP:GenProp1296",
"GP:GenProp1351",
"GP:GenProp1658",
"REACTOME:R-BTA-196807",
"REACTOME:R-CEL-1483191",
"REACTOME:R-CEL-196807",
"REACTOME:R-DDI-1483213",
"REACTOME:R-DME-196807",
"REACTOME:R-DRE-196807",
"REACTOME:R-HSA-1483191",
"REACTOME:... | 32 | [
"1b6t",
"1coz",
"1ej2",
"1f9a",
"1gn8",
"1gzu",
"1h1t",
"1hyb",
"1iho",
"1k4k",
"1k4m",
"1kam",
"1kaq",
"1kku",
"1kqn",
"1kqo",
"1kr2",
"1lw7",
"1m8f",
"1m8g",
"1m8j",
"1m8k",
"1n1d",
"1nup",
"1nuq",
"1nur",
"1nus",
"1nut",
"1nuu",
"1o6b",
"1od6",
"1qjc"... | 270 | [
"PUB00034486",
"PUB00056773"
] | [
"16344011",
"20822113"
] | [
"Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism.",
"Archaeal RibL: a new FAD synthetase that is air sensitive."
] | [
2006,
2010
] | 2 | [] | [
"IPR041723",
"IPR041750"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
3001,
91743,
27676,
510,
2362
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
37,
17,
17,
10,
6,
38,
22,
3,
32,
33,
6,
5,
43
] | 13 | true | Domain | Cytidyltransferase-like domain | Cytidyltransferase-like domain | Cyt_trans-like | 3 |
IPR004823 | 4,823 | TATA box binding protein associated factor (TAF), histone-like fold domain | TAF_TATA-bd_Histone-like_dom | Domain | 10,809 | false | false | The TATA box binding protein associated factor (TAF) is part of the transcription initiation factor TFIID multimeric protein complex. TFIID plays a central role in mediating promoter responses to various activators and repressors. It binds tightly to TAFII-250 and directly interacts with TAFII-40. TFIID is composed of ... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF02969",
"SM00803"
] | [
"TAF",
"TAF"
] | [
6208,
9991
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-110330",
"R-BTA-110331",
"R-BTA-171306",
"R-BTA-201722",
"R-BTA-212300",
"R-BTA-2299718",
"R-BTA-2559580",
"R-BTA-2559582",
"R-BTA-2559586",
"R-BTA-3214815",
"R-BTA-3214841",
"R-BTA-3214842",
"R-BTA-3214847",
"R-BTA-3214858",
"R-BTA-427359",
"R-BTA-427413",
"R-BTA-4551638",
... | [
"REACTOME:R-BTA-110330",
"REACTOME:R-BTA-110331",
"REACTOME:R-BTA-171306",
"REACTOME:R-BTA-201722",
"REACTOME:R-BTA-212300",
"REACTOME:R-BTA-2299718",
"REACTOME:R-BTA-2559580",
"REACTOME:R-BTA-2559582",
"REACTOME:R-BTA-2559586",
"REACTOME:R-BTA-3214815",
"REACTOME:R-BTA-3214841",
"REACTOME:R-B... | 266 | [
"1aoi",
"1eqz",
"1f66",
"1hio",
"1hq3",
"1kx3",
"1kx4",
"1kx5",
"1m18",
"1m19",
"1m1a",
"1p34",
"1p3a",
"1p3g",
"1p3k",
"1p3l",
"1p3m",
"1p3p",
"1s32",
"1taf",
"1tzy",
"1u35",
"1zbb",
"1zla",
"2aro",
"2cv5",
"2f8n",
"2fj7",
"2hio",
"2hue",
"2io5",
"2nqb"... | 936 | [
"PUB00075536",
"PUB00087622",
"PUB00087636",
"PUB00099783"
] | [
"22696218",
"10788514",
"8946909",
"29485702"
] | [
"TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.",
"Identification of two novel TAF subunits of the yeast Saccharomyces cerevisiae TFIID complex.",
"The general transcription factors of RNA polymerase II.",
"Mutational analysis ... | [
2012,
2000,
1996,
2018
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Eukaryota",
"Gammaproteobacteria",
"Viruses incertae sedis",
"invertebrate metagenome"
] | [
129,
10628,
3,
48,
1
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
14,
1,
11,
4,
22,
12,
2,
2,
10,
1,
1,
10
] | 12 | true | Domain | TATA box binding protein associated factor (TAF), histone-like fold domain | TATA box binding protein associated factor (TAF), histone-like fold domain | TAF_TATA-bd_Histone-like_dom | 7 |
IPR004825 | 4,825 | Insulin | Insulin | Family | 1,451 | false | false | Insulin is found in many animals, and is involved in the regulation of normal glucose homeostasis. It also has other specific physiological effects, such as increasing the permeability of cells to monosaccharides, amino acids and fatty acids, and accelerating glycolysis and glycogen synthesis in the liver [ ]. Insulin ... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS",
"PANTHER",
"CDD"
] | [
"PR00277",
"PTHR11454",
"cd04367"
] | [
"INSULIN",
"",
"IlGF_insulin_like"
] | [
1224,
1403,
1402
] | 3 | [
"GP",
"GP",
"GP",
"GP",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"R... | [
"GenProp2086",
"GenProp2088",
"GenProp2090",
"GenProp2097",
"PDOC00235",
"R-CFA-264876",
"R-CFA-422085",
"R-CFA-6807878",
"R-CFA-6811558",
"R-CFA-74713",
"R-CFA-74749",
"R-CFA-74751",
"R-CFA-74752",
"R-CFA-77387",
"R-DRE-264876",
"R-DRE-422085",
"R-DRE-74749",
"R-DRE-74752",
"R-D... | [
"GP:GenProp2086",
"GP:GenProp2088",
"GP:GenProp2090",
"GP:GenProp2097",
"PROSITEDOC:PDOC00235",
"REACTOME:R-CFA-264876",
"REACTOME:R-CFA-422085",
"REACTOME:R-CFA-6807878",
"REACTOME:R-CFA-6811558",
"REACTOME:R-CFA-74713",
"REACTOME:R-CFA-74749",
"REACTOME:R-CFA-74751",
"REACTOME:R-CFA-74752"... | 68 | [
"1a7f",
"1ai0",
"1aiy",
"1aph",
"1b17",
"1b18",
"1b19",
"1b2a",
"1b2b",
"1b2c",
"1b2d",
"1b2e",
"1b2f",
"1b2g",
"1b9e",
"1ben",
"1bph",
"1bzv",
"1cph",
"1dei",
"1dph",
"1efe",
"1ev3",
"1ev6",
"1evr",
"1fu2",
"1fub",
"1g7a",
"1g7b",
"1guj",
"1hiq",
"1his"... | 435 | [
"PUB00003970",
"PUB00003972",
"PUB00003973",
"PUB00023078",
"PUB00037375",
"PUB00053639",
"PUB00053640",
"PUB00053641",
"PUB00053642",
"PUB00096674"
] | [
"503234",
"6243748",
"6107857",
"2036417",
"9141131",
"10601981",
"8735594",
"8683595",
"1319992",
"30747102"
] | [
"Nucleotide sequence of a cDNA clone encoding human preproinsulin.",
"Sequence of the human insulin gene.",
"Hormone families: pancreatic hormones and homologous growth factors.",
"Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.",... | [
1979,
1980,
1980,
1991,
1997,
1999,
1996,
1996,
1992,
2019
] | 10 | [
"IPR022352"
] | [] | 1 | 0 | 1 | [
"Brevibacillus brevis",
"Eukaryota"
] | [
1,
1450
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
7,
8,
6
] | 4 | true | Family | Insulin | Insulin | Insulin | 3 |
IPR004826 | 4,826 | Basic leucine zipper domain, Maf-type | bZIP_Maf | Domain | 14,901 | false | false | Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [ ]. This entry also includes the DNA binding domain of Skn-1 ( ); this domain lacks the leucine zipper found in other bZip domains, and binds DNA as a monomer [ , ]. | [
"GO:0003677",
"GO:0006355"
] | [
"DNA binding",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF03131"
] | [
"bZIP_Maf"
] | [
14901
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-983231",
"R-CEL-8951664",
"R-CEL-9755511",
"R-CEL-9759194",
"R-CEL-9762114",
"R-DME-8951664",
"R-DME-9755511",
"R-DME-9759194",
"R-DME-9762114",
"R-DME-983231",
"R-GGA-9707616",
"R-GGA-9708530",
"R-HSA-210745",
"R-HSA-5617472",
"R-HSA-8936459",
"R-HSA-8940973",
"R-HSA-8951664"... | [
"REACTOME:R-BTA-983231",
"REACTOME:R-CEL-8951664",
"REACTOME:R-CEL-9755511",
"REACTOME:R-CEL-9759194",
"REACTOME:R-CEL-9762114",
"REACTOME:R-DME-8951664",
"REACTOME:R-DME-9755511",
"REACTOME:R-DME-9759194",
"REACTOME:R-DME-9762114",
"REACTOME:R-DME-983231",
"REACTOME:R-GGA-9707616",
"REACTOME:... | 45 | [
"1k1v",
"1skn",
"2kz5",
"2lz1",
"2wt7",
"2wty",
"3a5t",
"4auw",
"4eot",
"7o7b",
"7x5e",
"7x5f",
"7x5g"
] | 13 | [
"PUB00011711",
"PUB00019238",
"PUB00066688"
] | [
"9628487",
"11416124",
"7939715"
] | [
"A new DNA-binding motif in the Skn-1 binding domain-DNA complex.",
"Phosphorylation of MafA is essential for its transcriptional and biological properties.",
"Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements."
] | [
1998,
2001,
1994
] | 3 | [] | [
"IPR043321"
] | 0 | 1 | 0 | [
"Avian musculoaponeurotic fibrosarcoma virus AS42",
"Bacteria",
"Eukaryota"
] | [
1,
4,
14896
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
55,
12,
45,
42,
47
] | 6 | true | Domain | Basic leucine zipper domain, Maf-type | Basic leucine zipper domain, Maf-type | bZIP_Maf | 8 |
IPR004827 | 4,827 | Basic-leucine zipper domain | bZIP | Domain | 153,121 | false | false | The basic-leucine zipper (bZIP) domain transcription factors [ ] of eukaryotic are proteins that contain a basic region mediating sequence-specific DNA-binding followed by a leucine zipper region required for dimerisation. Several structure of bZIP have been solved. The basic region and the leucine zipper form a contig... | [
"GO:0003700",
"GO:0006355"
] | [
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PFAM",
"PROSITE",
"PROFILE",
"SMART"
] | [
"PF00170",
"PF07716",
"PS00036",
"PS50217",
"SM00338"
] | [
"bZIP_1",
"bZIP_2",
"BZIP_BASIC",
"BZIP",
"BRLZ"
] | [
90000,
28298,
106459,
126777,
130842
] | 5 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00036",
"R-BTA-199920",
"R-BTA-2559580",
"R-BTA-2871796",
"R-BTA-450341",
"R-BTA-8874211",
"R-BTA-983231",
"R-CEL-198693",
"R-CEL-199920",
"R-CEL-2559580",
"R-CEL-2871796",
"R-CEL-3214847",
"R-CEL-375165",
"R-CEL-381033",
"R-CEL-442742",
"R-CEL-450341",
"R-CEL-881907",
"R-CEL-... | [
"PROSITEDOC:PDOC00036",
"REACTOME:R-BTA-199920",
"REACTOME:R-BTA-2559580",
"REACTOME:R-BTA-2871796",
"REACTOME:R-BTA-450341",
"REACTOME:R-BTA-8874211",
"REACTOME:R-BTA-983231",
"REACTOME:R-CEL-198693",
"REACTOME:R-CEL-199920",
"REACTOME:R-CEL-2559580",
"REACTOME:R-CEL-2871796",
"REACTOME:R-CEL... | 195 | [
"1a02",
"1ci6",
"1dgc",
"1dh3",
"1fos",
"1gd2",
"1gtw",
"1gu4",
"1gu5",
"1h88",
"1h89",
"1h8a",
"1hjb",
"1io4",
"1jnm",
"1jun",
"1ld4",
"1nwq",
"1s9k",
"1skn",
"1t2k",
"1u2u",
"1ysa",
"2c9l",
"2c9n",
"2dgc",
"2e42",
"2e43",
"2h7h",
"2kz5",
"2lz1",
"2oqq"... | 82 | [
"PUB00004967",
"PUB00017872"
] | [
"7780801",
"1473154"
] | [
"Transcription factors 1: bZIP proteins.",
"The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex."
] | [
1995,
1992
] | 2 | [] | [
"IPR044759",
"IPR045314",
"IPR047106"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
9,
111,
152560,
433,
8
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
347,
32,
194,
76,
180,
190,
23,
219,
211,
13,
6,
639
] | 12 | true | Domain | Basic-leucine zipper domain | Basic-leucine zipper domain | bZIP | 8 |
IPR004830 | 4,830 | Leucine rich repeat variant | LRR_variant | Repeat | 1,206 | false | false | Leucine-rich repeats (LRR) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape [ ]. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions [ , ].Proteins containing LR... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01816"
] | [
"LRV"
] | [
1206
] | 1 | [] | [] | [] | 0 | [
"1lrv"
] | 1 | [
"PUB00001625",
"PUB00001898",
"PUB00003936",
"PUB00007147",
"PUB00007148",
"PUB00017058",
"PUB00094376"
] | [
"1657640",
"2176636",
"8946850",
"11751054",
"11967365",
"14747988",
"21606681"
] | [
"A leucine-rich repeat peptide derived from the Drosophila Toll receptor forms extended filaments with a beta-sheet structure.",
"slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.",
"A leucine-rich repeat variant with a nove... | [
1991,
1990,
1996,
2001,
2002,
2004,
2011
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Lithodesmiaceae",
"ecological metagenomes",
"uncultured Caudovirales phage"
] | [
9,
1174,
2,
18,
3
] | 5 | [] | [] | 0 | true | Repeat | Leucine rich repeat variant | Leucine rich repeat variant | LRR_variant | 9 |
IPR004832 | 4,832 | TCL1/MTCP1 | TCL1_MTCP1 | Family | 966 | false | false | This entry represents MTCP1 and TCL1A/B from animals. They are encoded from a family of protooncogenes and function as Akt kinase coactivators [ ]. TCL1 also acts as an NFkappaB activator, through the interaction with p300, and as an inhibitor of AP1-dependent transcription [ ]. It affects both hair growth and epidermi... | [
"GO:0043539"
] | [
"protein serine/threonine kinase activator activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF01840",
"PTHR14060"
] | [
"TCL1_MTCP1",
""
] | [
965,
954
] | 2 | [] | [] | [] | 0 | [
"1a1x",
"1jnp",
"1jsg",
"1qtt",
"1qtu",
"9lq1"
] | 6 | [
"PUB00092565",
"PUB00092566",
"PUB00092567"
] | [
"10983986",
"19064921",
"30286151"
] | [
"The protooncogene TCL1 is an Akt kinase coactivator.",
"Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.",
"T Cell Leukemia/Lymphoma 1A is essential for mouse epidermal keratinocytes proliferation promoted by insulin-like growth factor 1."
] | [
2000,
2008,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Amniota"
] | [
966
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
20,
8
] | 3 | true | Family | TCL1/MTCP1 | TCL1/MTCP1 | TCL1_MTCP1 | 7 |
IPR004835 | 4,835 | Chitin synthase | Chitin_synth | Family | 21,849 | false | false | Chitin synthase ( ), also known as chitin-UDP acetyl-glucosaminyl transferase, is a plasma membrane-bound protein which catalyses the conversion of UDP-N-acettyl-D-glucosamine and {(1,4)-(N-acetyl- beta-D-glucosaminyl)}(N) to UDP and {(1,4)-(N-acetyl-beta-D- glucosaminyl)}(N+1) to produce chitin, an abundant biopolymer... | [
"GO:0004100",
"GO:0016758"
] | [
"chitin synthase activity",
"hexosyltransferase activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PANTHER"
] | [
"PTHR22914"
] | [
""
] | [
21849
] | 1 | [
"EC",
"METACYC"
] | [
"2.4.1.16",
"PWY-6981"
] | [
"EC:2.4.1.16",
"METACYC:PWY-6981"
] | 2 | [
"7stl",
"7stm",
"7stn",
"7sto",
"7wjm",
"7wjn",
"7wjo",
"7x05",
"7x06",
"7xs6",
"7xs7",
"8k3p",
"8k3q",
"8k3r",
"8k3t",
"8k3u",
"8k3v",
"8k3w",
"8k3x",
"8k52",
"8z0o"
] | 21 | [
"PUB00096620",
"PUB00096621",
"PUB00096622",
"PUB00096626",
"PUB00096627"
] | [
"16278457",
"16098962",
"20971008",
"26870058",
"28300148"
] | [
"A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen Cryptococcus neoformans.",
"The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively.",
"E... | [
2005,
2005,
2010,
2016,
2017
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Megaviricetes",
"Pseudomonadota",
"metagenomes"
] | [
21796,
22,
26,
5
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
10,
12,
7,
3,
2
] | 6 | true | Family | Chitin synthase | Chitin synthase | Chitin_synth | 2 |
IPR004836 | 4,836 | Sodium/calcium exchanger protein | Na_Ca_Ex | Family | 9,061 | false | false | Na + /Ca 2+ exchange proteins are involved in maintaining Ca 2+ homeostasis in a wide variety of cell types. They are found in both the plasma membrane and intracellular organellar membranes, where they exchange Na + for Ca 2+ in an electrogenic manner. When located in the plasma membrane, they generally utilise the tr... | [
"GO:0005432",
"GO:0006816",
"GO:0016020"
] | [
"calcium:sodium antiporter activity",
"calcium ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS",
"NCBIFAM"
] | [
"PR01259",
"TIGR00845"
] | [
"NACAEXCHNGR",
"caca"
] | [
7713,
6805
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-418359",
"R-CFA-425561",
"R-CFA-5578775",
"R-HSA-418359",
"R-HSA-425561",
"R-HSA-5578775",
"R-HSA-8949215",
"R-MMU-418359",
"R-MMU-425561",
"R-MMU-5578775",
"R-RNO-418359",
"R-RNO-425561",
"R-RNO-5578775"
] | [
"REACTOME:R-CFA-418359",
"REACTOME:R-CFA-425561",
"REACTOME:R-CFA-5578775",
"REACTOME:R-HSA-418359",
"REACTOME:R-HSA-425561",
"REACTOME:R-HSA-5578775",
"REACTOME:R-HSA-8949215",
"REACTOME:R-MMU-418359",
"REACTOME:R-MMU-425561",
"REACTOME:R-MMU-5578775",
"REACTOME:R-RNO-418359",
"REACTOME:R-RNO... | 13 | [
"8jp0",
"8sgi",
"8sgj",
"8sgt",
"9iv8"
] | 5 | [
"PUB00002973",
"PUB00005133",
"PUB00006595"
] | [
"8798769",
"1700476",
"8021246"
] | [
"Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3.",
"Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.",
"Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger."
] | [
1996,
1990,
1994
] | 3 | [] | [
"IPR002987"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"candidate division MSBL1 archaeon SCGC-AAA382C18"
] | [
3,
9057,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
81,
7,
20,
19,
24
] | 6 | true | Family | Sodium/calcium exchanger protein | Sodium/calcium exchanger protein | Na_Ca_Ex | 6 |
IPR004837 | 4,837 | Sodium/calcium exchanger membrane region | NaCa_Exmemb | Domain | 76,730 | false | false | The sodium/calcium exchangers are a family of integral membrane proteins. This domain covers the integral membrane regions of these proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells... | [
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF01699"
] | [
"Na_Ca_ex"
] | [
76730
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-425561",
"R-CEL-8949215",
"R-CFA-418359",
"R-CFA-425561",
"R-CFA-5578775",
"R-DME-425561",
"R-HSA-2485179",
"R-HSA-418359",
"R-HSA-425561",
"R-HSA-5578775",
"R-HSA-5619036",
"R-HSA-5619055",
"R-HSA-5619077",
"R-HSA-8949215",
"R-MMU-418359",
"R-MMU-425561",
"R-MMU-5578775",
"... | [
"REACTOME:R-CEL-425561",
"REACTOME:R-CEL-8949215",
"REACTOME:R-CFA-418359",
"REACTOME:R-CFA-425561",
"REACTOME:R-CFA-5578775",
"REACTOME:R-DME-425561",
"REACTOME:R-HSA-2485179",
"REACTOME:R-HSA-418359",
"REACTOME:R-HSA-425561",
"REACTOME:R-HSA-5578775",
"REACTOME:R-HSA-5619036",
"REACTOME:R-HS... | 26 | [
"3v5s",
"3v5u",
"4k1c",
"4kjr",
"4kjs",
"4kpp",
"5hwx",
"5hwy",
"5hxc",
"5hxe",
"5hxh",
"5hxr",
"5hxs",
"5hya",
"5jdf",
"5jdg",
"5jdh",
"5jdl",
"5jdm",
"5jdn",
"5jdq",
"8jp0",
"8sgi",
"8sgj",
"8sgt",
"9iv8",
"9ps1",
"9ps2",
"9ps3",
"9ps4",
"9ps6",
"9ps8"... | 35 | [
"PUB00002973",
"PUB00005133"
] | [
"8798769",
"1700476"
] | [
"Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3.",
"Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger."
] | [
1996,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Terrestrivirus sp.",
"unclassified sequences"
] | [
1917,
24360,
49941,
1,
511
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
62,
18,
124,
39,
2,
42,
35,
10,
35,
50,
4,
3,
107
] | 13 | true | Domain | Sodium/calcium exchanger membrane region | Sodium/calcium exchanger membrane region | NaCa_Exmemb | 7 |
IPR004838 | 4,838 | Aminotransferases, class-I, pyridoxal-phosphate-binding site | NHTrfase_class1_PyrdxlP-BS | Binding_site | 102,107 | false | false | Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [ , , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of a... | [
"GO:0003824",
"GO:0030170",
"GO:0009058"
] | [
"catalytic activity",
"pyridoxal phosphate binding",
"biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PROSITE"
] | [
"PS00105"
] | [
"AA_TRANSFER_CLASS_1"
] | [
102107
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.6.1",
"PDOC00098",
"R-BTA-389661",
"R-BTA-8963684",
"R-BTA-8963693",
"R-BTA-8964539",
"R-BTA-9856872",
"R-CEL-8963693",
"R-CEL-9856872",
"R-DDI-389661",
"R-DDI-8963684",
"R-DDI-8963693",
"R-DDI-8964539",
"R-DDI-9856872",
"R-GGA-352875",
"R-GGA-372568",
"R-HSA-1237112",
"R-HSA-16... | [
"EC:2.6.1",
"PROSITEDOC:PDOC00098",
"REACTOME:R-BTA-389661",
"REACTOME:R-BTA-8963684",
"REACTOME:R-BTA-8963693",
"REACTOME:R-BTA-8964539",
"REACTOME:R-BTA-9856872",
"REACTOME:R-CEL-8963693",
"REACTOME:R-CEL-9856872",
"REACTOME:R-DDI-389661",
"REACTOME:R-DDI-8963684",
"REACTOME:R-DDI-8963693",
... | 51 | [
"1aam",
"1aat",
"1aaw",
"1ahe",
"1ahf",
"1ahg",
"1ahx",
"1ahy",
"1ajr",
"1ajs",
"1ama",
"1amq",
"1amr",
"1ams",
"1arg",
"1arh",
"1ari",
"1ars",
"1art",
"1asa",
"1asb",
"1asc",
"1asd",
"1ase",
"1asf",
"1asg",
"1asl",
"1asm",
"1asn",
"1b4x",
"1b5o",
"1b5p"... | 215 | [
"PUB00002679",
"PUB00006322",
"PUB00035504",
"PUB00035505",
"PUB00035506",
"PUB00035507",
"PUB00035508"
] | [
"1990006",
"7748903",
"15581583",
"8690703",
"15189147",
"17109392",
"16763894"
] | [
"Thermostable aspartate aminotransferase from a thermophilic Bacillus species. Gene cloning, sequence determination, and preliminary x-ray characterization.",
"Pyridoxal phosphate-dependent enzymes.",
"Reaction specificity in pyridoxal phosphate enzymes.",
"Pyridoxal enzymes: mechanistic diversity and uniform... | [
1991,
1995,
2005,
1995,
2004,
2006,
2006
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ctTrm2",
"unclassified sequences"
] | [
3063,
71158,
26515,
1,
1370
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
83,
3,
8,
6,
2,
10,
4,
4,
36,
13,
3,
1,
71
] | 13 | true | Binding_site | Aminotransferases, class-I, pyridoxal-phosphate-binding site | Aminotransferases, class-I, pyridoxal-phosphate-binding site | NHTrfase_class1_PyrdxlP-BS | 5 |
IPR004839 | 4,839 | Aminotransferase, class I/classII, large domain | Aminotransferase_I/II_large | Domain | 427,261 | false | false | Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes, such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped [ ] into class I and class II. This entry includes proteins ... | [
"GO:0030170",
"GO:0009058"
] | [
"pyridoxal phosphate binding",
"biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF00155"
] | [
"Aminotran_1_2"
] | [
427261
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"2.6.1",
"GenProp1233",
"GenProp1245",
"GenProp1250",
"GenProp1251",
"GenProp1281",
"GenProp1292",
"GenProp1333",
"GenProp1358",
"GenProp1365",
"GenProp1404",
"GenProp1419",
"GenProp1423",
"GenProp1487",
"GenProp1503",
"GenProp1525",
"GenProp1584",
"GenProp1655",
"GenProp1657",
... | [
"EC:2.6.1",
"GP:GenProp1233",
"GP:GenProp1245",
"GP:GenProp1250",
"GP:GenProp1251",
"GP:GenProp1281",
"GP:GenProp1292",
"GP:GenProp1333",
"GP:GenProp1358",
"GP:GenProp1365",
"GP:GenProp1404",
"GP:GenProp1419",
"GP:GenProp1423",
"GP:GenProp1487",
"GP:GenProp1503",
"GP:GenProp1525",
"G... | 118 | [
"1aam",
"1aat",
"1aaw",
"1ahe",
"1ahf",
"1ahg",
"1ahx",
"1ahy",
"1aia",
"1aib",
"1aic",
"1ajr",
"1ajs",
"1aka",
"1akb",
"1akc",
"1ama",
"1amq",
"1amr",
"1ams",
"1arg",
"1arh",
"1ari",
"1ars",
"1art",
"1asa",
"1asb",
"1asc",
"1asd",
"1ase",
"1asf",
"1asg"... | 553 | [
"PUB00002679",
"PUB00043268"
] | [
"1990006",
"17583737"
] | [
"Thermostable aspartate aminotransferase from a thermophilic Bacillus species. Gene cloning, sequence determination, and preliminary x-ray characterization.",
"Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants... | [
1991,
2007
] | 2 | [] | [
"IPR010961"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
6203,
319757,
96021,
23,
5257
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
173,
16,
46,
23,
13,
66,
54,
14,
117,
89,
12,
11,
281
] | 13 | true | Domain | Aminotransferase, class I/classII, large domain | Aminotransferase, class I/classII, large domain | Aminotransferase_I/II_large | 4 |
IPR004840 | 4,840 | Amino acid permease, conserved site | Amino_acid_permease_CS | Conserved_site | 65,704 | false | false | This entry represents a conserved region located in the second transmembrane segment of amino acid permeases mainly found in bacteria and fungi. Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary relate... | [
"GO:0006865",
"GO:0055085",
"GO:0016020"
] | [
"amino acid transport",
"transmembrane transport",
"membrane"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS00218"
] | [
"AMINO_ACID_PERMEASE_1"
] | [
65704
] | 1 | [
"PROSITEDOC"
] | [
"PDOC00191"
] | [
"PROSITEDOC:PDOC00191"
] | 1 | [
"9eyd"
] | 1 | [
"PUB00001779",
"PUB00003402",
"PUB00005006"
] | [
"2687114",
"3146645",
"8382989"
] | [
"Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.",
"Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae.",
"Mammalian integral membrane receptors are homo... | [
1989,
1988,
1993
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
27,
42062,
23569,
46
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
9,
9,
4,
19,
14
] | 5 | true | Conserved_site | Amino acid permease, conserved site | Amino acid permease, conserved site | Amino_acid_permease_CS | 4 |
IPR004841 | 4,841 | Amino acid permease/SLC12A domain | AA-permease/SLC12A_dom | Domain | 117,189 | false | false | Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [ , , ]. These proteins seem to contain up to 12 transmembrane segments. The best conserved region in this family is located in the second tran... | [
"GO:0055085",
"GO:0016020"
] | [
"transmembrane transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF00324"
] | [
"AA_permease"
] | [
117189
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-426117",
"R-DRE-426117",
"R-HSA-426117",
"R-HSA-5619039",
"R-HSA-5619087",
"R-HSA-5619104",
"R-MMU-426117",
"R-RNO-426117"
] | [
"REACTOME:R-CEL-426117",
"REACTOME:R-DRE-426117",
"REACTOME:R-HSA-426117",
"REACTOME:R-HSA-5619039",
"REACTOME:R-HSA-5619087",
"REACTOME:R-HSA-5619104",
"REACTOME:R-MMU-426117",
"REACTOME:R-RNO-426117"
] | 8 | [
"6kkr",
"6kkt",
"6kku",
"6m1y",
"6m22",
"6m23",
"6nph",
"6npk",
"6npl",
"6pzt",
"6ukn",
"6y5r",
"6y5v",
"7ain",
"7aio",
"7aip",
"7aiq",
"7air",
"7d10",
"7d14",
"7d8z",
"7d90",
"7d99",
"7mxo",
"7n3n",
"7ngb",
"7s1x",
"7s1y",
"7s1z",
"7sfl",
"7smp",
"7tth"... | 50 | [
"PUB00001779",
"PUB00003402",
"PUB00005006"
] | [
"2687114",
"3146645",
"8382989"
] | [
"Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.",
"Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae.",
"Mammalian integral membrane receptors are homo... | [
1989,
1988,
1993
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
899,
60910,
55117,
263
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
7,
24,
57,
15,
12,
57,
44,
11,
6,
63,
20,
14,
38
] | 13 | true | Domain | Amino acid permease/SLC12A domain | Amino acid permease/SLC12A domain | AA-permease/SLC12A_dom | 9 |
IPR004842 | 4,842 | SLC12A transporter family | SLC12A_fam | Family | 27,364 | false | false | This is a family of K-Cl cotransporters. It includes bumetanide-sensitive sodium-(potassium)-chloride cotransporter, an electrically silent transporter system which is a mediator of sodium and chloride reabsorption. It plays a vital role in the regulation of ionic balance and cell volume. Bumetanide-sensitive sodium-(p... | [
"GO:0015377",
"GO:0006811",
"GO:0016020"
] | [
"chloride:monoatomic cation symporter activity",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR11827",
"TIGR00930"
] | [
"",
"2a30"
] | [
27363,
13902
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-426117",
"R-DRE-426117",
"R-HSA-426117",
"R-HSA-5619039",
"R-HSA-5619087",
"R-HSA-5619104",
"R-MMU-426117",
"R-RNO-426117"
] | [
"REACTOME:R-CEL-426117",
"REACTOME:R-DRE-426117",
"REACTOME:R-HSA-426117",
"REACTOME:R-HSA-5619039",
"REACTOME:R-HSA-5619087",
"REACTOME:R-HSA-5619104",
"REACTOME:R-MMU-426117",
"REACTOME:R-RNO-426117"
] | 8 | [
"6kkr",
"6kkt",
"6kku",
"6m1y",
"6m22",
"6m23",
"6nph",
"6npj",
"6npk",
"6npl",
"6pzt",
"6ukn",
"6vw9",
"6vwa",
"6y5r",
"6y5v",
"7ain",
"7aio",
"7aip",
"7aiq",
"7air",
"7d10",
"7d14",
"7d8z",
"7d90",
"7d99",
"7mxo",
"7n3n",
"7ngb",
"7s1x",
"7s1y",
"7s1z"... | 53 | [] | [] | [] | [] | 0 | [] | [
"IPR000076",
"IPR002443",
"IPR002948"
] | 0 | 3 | 0 | [
"Bacteria",
"Eukaryota",
"Methanomicrobia",
"metagenomes"
] | [
587,
26740,
14,
23
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
24,
57,
15,
66,
46,
1,
6,
66,
1,
1,
37
] | 12 | true | Family | SLC12A transporter family | SLC12A transporter family | SLC12A_fam | 5 |
IPR004843 | 4,843 | Calcineurin-like, phosphoesterase domain | Calcineurin-like_PHP | Domain | 372,703 | false | false | This domain is found in a diverse range of phosphoesterases [ ], including bis(5'-nucleosyl)-tetraphosphatase (apaH), nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases, as well as nucleases such as bacterial SbcD or archaeal/yeast Mre11. The most conserved regions in the Calcineurin-like... | [
"GO:0016787"
] | [
"hydrolase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00149"
] | [
"Metallophos"
] | [
372703
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-113501",
"R-BTA-1295596",
"R-BTA-141444",
"R-BTA-180024",
"R-BTA-195253",
"R-BTA-196299",
"R-BTA-198753",
"R-BTA-2025928",
"R-BTA-202670",
"R-BTA-2467813",
"R-BTA-2500257",
"R-BTA-2565942",
"R-BTA-2871809",
"R-BTA-2995383",
"R-BTA-389356",
"R-BTA-389513",
"R-BTA-4086398",
"R... | [
"REACTOME:R-BTA-113501",
"REACTOME:R-BTA-1295596",
"REACTOME:R-BTA-141444",
"REACTOME:R-BTA-180024",
"REACTOME:R-BTA-195253",
"REACTOME:R-BTA-196299",
"REACTOME:R-BTA-198753",
"REACTOME:R-BTA-2025928",
"REACTOME:R-BTA-202670",
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA-2500257",
"REACTOME:R-BTA... | 403 | [
"1aui",
"1fjm",
"1g5b",
"1ho5",
"1hp1",
"1hpu",
"1ii7",
"1it6",
"1jk7",
"1kbp",
"1m63",
"1mf8",
"1oi8",
"1oid",
"1oie",
"1qfc",
"1qhw",
"1s70",
"1s8e",
"1s95",
"1tco",
"1u32",
"1ush",
"1ute",
"1v73",
"1wao",
"1war",
"1xm7",
"1xzw",
"2bcd",
"2bdx",
"2bq8"... | 435 | [
"PUB00019430"
] | [
"9685491"
] | [
"Phosphoesterase domains associated with DNA polymerases of diverse origins."
] | [
1998
] | 1 | [] | [
"IPR006186",
"IPR039541",
"IPR041780",
"IPR041796",
"IPR041805",
"IPR041816",
"IPR041821",
"IPR041823",
"IPR041825",
"IPR041827",
"IPR041831",
"IPR041834",
"IPR041867",
"IPR041869",
"IPR041871"
] | 0 | 15 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
5336,
204411,
157193,
2875,
2888
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
292,
77,
99,
92,
9,
149,
76,
27,
184,
127,
20,
20,
441
] | 13 | true | Domain | Calcineurin-like, phosphoesterase domain | Calcineurin-like, phosphoesterase domain | Calcineurin-like_PHP | 7 |
IPR004845 | 4,845 | Type II secretion system protein GspD, conserved site | T2SS_GspD_CS | Conserved_site | 11,135 | false | false | A number of proteins are involved in the general secretion pathway (GSP); one of these is known as protein D (GSPD protein). Protein D is involved in the type II general secretion pathway within Gram-negative bacteria, a signal sequence-dependent process responsible for protein export [ , , , , , , ]. The most probable... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00875"
] | [
"T2SP_D"
] | [
11135
] | 1 | [
"PROSITEDOC"
] | [
"PDOC00683"
] | [
"PROSITEDOC:PDOC00683"
] | 1 | [
"4av2",
"5tcq",
"5tcr",
"5wln",
"5wq7",
"5wq8",
"5wq9",
"6dv3",
"6dv6",
"6hcg",
"6i1x",
"6i1y",
"6pee",
"6pem",
"6pep",
"6q14",
"6q15",
"6q16",
"6rwk",
"6ve2",
"6ve3",
"6ve4",
"6w6m",
"7ah9",
"7ahi",
"7ofh",
"8axk",
"8axl",
"8axn",
"9k8v"
] | 30 | [
"PUB00002179",
"PUB00002516",
"PUB00003764",
"PUB00003843",
"PUB00003848",
"PUB00003850",
"PUB00005409",
"PUB00005523"
] | [
"1592799",
"2677007",
"8190064",
"8326859",
"7901733",
"7934814",
"8438237",
"1365398"
] | [
"Determinants of extracellular protein secretion in gram-negative bacteria.",
"Protein secretion by gram-negative bacteria. Characterization of two membrane proteins required for pullulanase secretion by Escherichia coli K-12.",
"A superfamily of proteins involved in different secretion pathways in gram-negativ... | [
1992,
1989,
1994,
1993,
1993,
1993,
1993,
1992
] | 8 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Inoviridae",
"unclassified sequences"
] | [
10970,
20,
13,
132
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Conserved_site | Type II secretion system protein GspD, conserved site | Type II secretion system protein GspD, conserved site | T2SS_GspD_CS | 7 |
IPR004846 | 4,846 | Type II/III secretion system, secretin-like domain | T2SS/T3SS_dom | Domain | 35,752 | false | false | This family includes: protein D that is involved in the general (type II) secretion pathway (GSP) within Gram-negative bacteria, a signal sequence-dependent process responsible for protein export [ , , , , , , ] and protein G from the type III secretion system. A number of proteins are involved in the GSP; one of these... | [
"GO:0009306"
] | [
"protein secretion"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF00263"
] | [
"Secretin"
] | [
35752
] | 1 | [
"REACTOME"
] | [
"R-HSA-9760173"
] | [
"REACTOME:R-HSA-9760173"
] | 1 | [
"3jc8",
"3jc9",
"4av2",
"5tcq",
"5tcr",
"5w68",
"5wln",
"5wq7",
"5wq8",
"5wq9",
"5zdh",
"6dv3",
"6dv6",
"6hcg",
"6i1x",
"6i1y",
"6pee",
"6pem",
"6pep",
"6q14",
"6q15",
"6q16",
"6rwk",
"6ve2",
"6ve3",
"6ve4",
"6w6m",
"7ah9",
"7ahi",
"7ofh",
"8axk",
"8axl"... | 38 | [
"PUB00002179",
"PUB00002516",
"PUB00003764",
"PUB00003843",
"PUB00003848",
"PUB00003850",
"PUB00005409",
"PUB00005523",
"PUB00007583",
"PUB00007701"
] | [
"1592799",
"2677007",
"8190064",
"8326859",
"7901733",
"7934814",
"8438237",
"1365398",
"10564516",
"8733226"
] | [
"Determinants of extracellular protein secretion in gram-negative bacteria.",
"Protein secretion by gram-negative bacteria. Characterization of two membrane proteins required for pullulanase secretion by Escherichia coli K-12.",
"A superfamily of proteins involved in different secretion pathways in gram-negativ... | [
1992,
1989,
1994,
1993,
1993,
1993,
1993,
1992,
1999,
1996
] | 10 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Inoviridae",
"Plasmid R64",
"environmental samples",
"unclassified sequences"
] | [
35015,
85,
24,
1,
2,
625
] | 6 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | Type II/III secretion system, secretin-like domain | Type II/III secretion system, secretin-like domain | T2SS/T3SS_dom | 8 |
IPR004847 | 4,847 | Na(+)/H(+) antiporter subunit E1 | Antiport_suE1 | Family | 39 | false | false | The Mnh complex is a Na+/H+ antiporter that is involved in Na+ excretion. This entry represents Mnh complex subunit E1. It is encoded by one of the seven ORFs of the mnh operon of Staphylococcus aureus. The seven open reading frames (ORFs) are necessary for Na+/H+ antiporter function as demonstrated by functional compl... | [
"GO:0015297",
"GO:1902600",
"GO:0016020"
] | [
"antiporter activity",
"proton transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00942"
] | [
"2a6301s05"
] | [
39
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00010583"
] | [
"9852009"
] | [
"A putative multisubunit Na+/H+ antiporter from Staphylococcus aureus."
] | [
1998
] | 1 | [
"IPR002758"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Thermococcaceae"
] | [
34,
5
] | 2 | [] | [] | 0 | true | Family | Na(+)/H(+) antiporter subunit E1 | Na(+)/H(+) antiporter subunit E1 | Antiport_suE1 | 9 |
IPR004848 | 4,848 | African swine fever virus, family 110 | ASFV_fam_110 | Family | 269 | false | false | This entry represents a family of proteins specific to the African swine fever virus (ASFV) known as the 110 family [ ]. Proteins in this group are responsible for the redistribution of lumenal ER protein to an enlarged ERGIC compartment [ ]. They contain a central cysteine rich region with eight conserved cysteines. S... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01639"
] | [
"v110"
] | [
269
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003487",
"PUB00100272"
] | [
"2325202",
"15016891"
] | [
"Multigene families in African swine fever virus: family 110.",
"The subcellular distribution of multigene family 110 proteins of African swine fever virus is determined by differences in C-terminal KDEL endoplasmic reticulum retention motifs."
] | [
1990,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"African swine fever virus"
] | [
269
] | 1 | [] | [] | 0 | true | Family | African swine fever virus, family 110 | African swine fever virus, family 110 | ASFV_fam_110 | 6 |
IPR004849 | 4,849 | 6-phosphogluconate dehydrogenase, YqeC-type | 6DGDH_YqeC | Family | 9,663 | false | false | Bacillus subtilis contains three classes of 6-phosphogluconate dehydrogenases (6PGD), including Gnd (YqjI), GntZ and YqeC. This entry represent the YqeC class, which in B. subtilis is a truncated 6PGD that possesses a NAD+-dependent activity [ ]. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00872"
] | [
"gnd_rel"
] | [
9663
] | 1 | [
"GP"
] | [
"GenProp0120"
] | [
"GP:GenProp0120"
] | 1 | [
"4e21",
"6vpb",
"6xeq",
"8ihe",
"9ijb"
] | 5 | [
"PUB00017604",
"PUB00073769",
"PUB00073770",
"PUB00073771",
"PUB00073772"
] | [
"10658669",
"15231785",
"6402366",
"8829540",
"3208200"
] | [
"Analysis of two formaldehyde oxidation pathways in Methylobacillus flagellatus KT, a ribulose monophosphate cycle methylotroph.",
"The Bacillus subtilis yqjI gene encodes the NADP+-dependent 6-P-gluconate dehydrogenase in the pentose phosphate pathway.",
"6-phospho-D-gluconate dehydrogenase from Pseudomonas fl... | [
2000,
2004,
1983,
1996,
1988
] | 5 | [
"IPR006183"
] | [
"IPR032883"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
252,
9223,
47,
9,
132
] | 5 | [] | [] | 0 | true | Family | 6-phosphogluconate dehydrogenase, YqeC-type | 6-phosphogluconate dehydrogenase, YqeC-type | 6DGDH_YqeC | 8 |
IPR004850 | 4,850 | NtA (N-terminal agrin) domain | NtA_dom | Domain | 1,632 | false | false | Agrin is a multidomain heparan sulphate proteoglycan, that is a key organiser for the induction of postsynaptic specializations at the neuromuscular junction. Binding of agrin to basement membranes requires the amino terminal (NtA) domain [ ]. This region mediates high affinity interaction with the coiled-coil domain o... | [
"GO:0043236",
"GO:0043113"
] | [
"laminin binding",
"receptor clustering"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE"
] | [
"PF03146",
"PS51121"
] | [
"NtA",
"NTA"
] | [
1570,
1596
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC51121",
"R-HSA-1971475",
"R-HSA-2022928",
"R-HSA-2024096",
"R-HSA-216083",
"R-HSA-3000171",
"R-HSA-3000178",
"R-HSA-3560783",
"R-HSA-3560801",
"R-HSA-3656237",
"R-HSA-3656253",
"R-HSA-419037",
"R-HSA-4420332",
"R-HSA-9694614",
"R-HSA-975634",
"R-HSA-9820960",
"R-HSA-9833110",
... | [
"PROSITEDOC:PDOC51121",
"REACTOME:R-HSA-1971475",
"REACTOME:R-HSA-2022928",
"REACTOME:R-HSA-2024096",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-3000171",
"REACTOME:R-HSA-3000178",
"REACTOME:R-HSA-3560783",
"REACTOME:R-HSA-3560801",
"REACTOME:R-HSA-3656237",
"REACTOME:R-HSA-3656253",
"REACTOME:R... | 18 | [
"1jb3",
"1jc7",
"1pxu",
"3i70",
"8s9p"
] | 5 | [
"PUB00007702",
"PUB00007703",
"PUB00017011"
] | [
"9321698",
"11473262",
"12554653"
] | [
"Synaptic differentiation: the role of agrin in the formation and maintenance of the neuromuscular junction.",
"The laminin-binding domain of agrin is structurally related to N-TIMP-1.",
"Mapping of the laminin-binding site of the N-terminal agrin domain (NtA)."
] | [
1997,
2001,
2003
] | 3 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eumetazoa"
] | [
2,
1630
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
26,
1,
5,
4
] | 5 | true | Domain | NtA (N-terminal agrin) domain | NtA (N-terminal agrin) domain | NtA_dom | 4 |
IPR004852 | 4,852 | Di-haem cytochrome c peroxidase | Di-haem_cyt_c_peroxidsae | Domain | 17,044 | false | false | This is a group of distinct cytochrome c peroxidases (CCPs) that contain two haem groups. Similar to other cytochrome c peroxidases, they reduce hydrogen peroxide to water using c-type haem as an oxidizable substrate. However, since they possess two, instead of one, haem prosthetic groups, bacterial CCPs reduce hydroge... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF03150"
] | [
"CCP_MauG"
] | [
17044
] | 1 | [
"GP",
"GP",
"GP"
] | [
"GenProp0213",
"GenProp1254",
"GenProp1729"
] | [
"GP:GenProp0213",
"GP:GenProp1254",
"GP:GenProp1729"
] | 3 | [
"1eb7",
"1iqc",
"1nml",
"1rz5",
"1rz6",
"1zzh",
"2c1u",
"2c1v",
"2vhd",
"3hq6",
"3hq7",
"3hq8",
"3hq9",
"3l4m",
"3l4o",
"3o5c",
"3orv",
"3pxs",
"3pxt",
"3pxw",
"3rlm",
"3rmz",
"3rn0",
"3rn1",
"3sjl",
"3sle",
"3svw",
"3sws",
"3sxt",
"4aal",
"4aam",
"4aan"... | 53 | [
"PUB00007705",
"PUB00007706"
] | [
"8591033",
"9202457"
] | [
"Crystal structure of the di-haem cytochrome c peroxidase from Pseudomonas aeruginosa.",
"Organization of methylamine utilization genes (mau) in 'Methylobacillus flagellatum ' KT and analysis of mau mutants."
] | [
1995,
1997
] | 2 | [
"IPR009056"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"unclassified sequences"
] | [
16780,
19,
34,
211
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Di-haem cytochrome c peroxidase | Di-haem cytochrome c peroxidase | Di-haem_cyt_c_peroxidsae | 2 |
IPR004853 | 4,853 | Sugar phosphate transporter domain | Sugar_P_trans_dom | Domain | 47,295 | false | false | This domain is found in a number of sugar phosphate transporters, including those with a specificity for triose phosphate [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03151"
] | [
"TPT"
] | [
47295
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-173599",
"R-BTA-6787639",
"R-BTA-727802",
"R-CEL-173599",
"R-CEL-2022854",
"R-CEL-2022928",
"R-CEL-6787639",
"R-CEL-727802",
"R-DDI-6787639",
"R-DDI-727802",
"R-DME-173599",
"R-DME-2022854",
"R-DME-2022928",
"R-DME-6787639",
"R-DME-727802",
"R-HSA-173599",
"R-HSA-2022854",
"... | [
"REACTOME:R-BTA-173599",
"REACTOME:R-BTA-6787639",
"REACTOME:R-BTA-727802",
"REACTOME:R-CEL-173599",
"REACTOME:R-CEL-2022854",
"REACTOME:R-CEL-2022928",
"REACTOME:R-CEL-6787639",
"REACTOME:R-CEL-727802",
"REACTOME:R-DDI-6787639",
"REACTOME:R-DDI-727802",
"REACTOME:R-DME-173599",
"REACTOME:R-DM... | 29 | [
"5y78",
"5y79"
] | 2 | [
"PUB00020858"
] | [
"11432728"
] | [
"The drug/metabolite transporter superfamily."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
15,
47279,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
187,
9,
30,
8,
26,
28,
6,
118,
27,
2,
3,
314
] | 12 | true | Domain | Sugar phosphate transporter domain | Sugar phosphate transporter domain | Sugar_P_trans_dom | 5 |
IPR004854 | 4,854 | Ubiquitin fusion degradation protein UFD1-like | UFD1-like | Family | 8,637 | false | false | This entry includes Ubiquitin fusion degradation protein Ufd1 from fungi and Ufd1-like proteins from animals and plants. Ufd1 is a 40kDa protein involved in the ubiquitin fusion degradation (UFD) pathway, which recognises post-translational ubiquitin-protein conjugates for degradation, and is essential for vegetative c... | [
"GO:0006511"
] | [
"ubiquitin-dependent protein catabolic process"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR12555"
] | [
""
] | [
8637
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-110320",
"R-CEL-8951664",
"R-CEL-9755511",
"R-DDI-8951664",
"R-DDI-9755511",
"R-DME-110320",
"R-DME-5689880",
"R-DME-8951664",
"R-DME-9755511",
"R-HSA-110320",
"R-HSA-5689880",
"R-HSA-8951664",
"R-HSA-9755511",
"R-MMU-110320",
"R-MMU-5689880",
"R-MMU-8951664",
"R-MMU-9755511",... | [
"REACTOME:R-CEL-110320",
"REACTOME:R-CEL-8951664",
"REACTOME:R-CEL-9755511",
"REACTOME:R-DDI-8951664",
"REACTOME:R-DDI-9755511",
"REACTOME:R-DME-110320",
"REACTOME:R-DME-5689880",
"REACTOME:R-DME-8951664",
"REACTOME:R-DME-9755511",
"REACTOME:R-HSA-110320",
"REACTOME:R-HSA-5689880",
"REACTOME:R... | 27 | [
"1zc1",
"2yuj",
"8dar",
"8das",
"8dat",
"8dau",
"8dav",
"8daw"
] | 8 | [
"PUB00007707",
"PUB00007708",
"PUB00038834",
"PUB00085171",
"PUB00085175",
"PUB00085176",
"PUB00155902",
"PUB00155903"
] | [
"7615550",
"9063746",
"16004872",
"20206597",
"28355556",
"26471729",
"11781570",
"12847084"
] | [
"A proteolytic pathway that recognizes ubiquitin as a degradation signal.",
"UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome.",
"Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites.",
"The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-prote... | [
1995,
1997,
2005,
2010,
2017,
2015,
2001,
2003
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Imitervirales",
"Parendozoicomonas callyspongiae",
"metagenomes"
] | [
8615,
3,
1,
18
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
21,
2,
1,
1,
8,
4,
2,
14,
4,
1,
1,
18
] | 12 | true | Family | Ubiquitin fusion degradation protein UFD1-like | Ubiquitin fusion degradation protein UFD1-like | UFD1-like | 2 |
IPR004855 | 4,855 | Transcription factor IIA, alpha/beta subunit | TFIIA_asu/bsu | Family | 6,302 | false | false | Transcription factor IIA (TFIIA) is one of several factors that form part of a transcription pre-initiation complex along with RNA polymerase II, the TATA-box-binding protein (TBP) and TBP-associated factors, on the TATA-box sequence upstream of the initiation start site. After initiation, some components of the pre-in... | [
"GO:0006367",
"GO:0005672"
] | [
"transcription initiation at RNA polymerase II promoter",
"transcription factor TFIIA complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER",
"SMART"
] | [
"PF03153",
"PTHR12694",
"SM01371"
] | [
"TFIIA",
"",
"TFIIA"
] | [
6109,
5846,
5948
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DDI-674695",
"R-DDI-6807505",
"R-DDI-73776",
"R-DDI-73779",
"R-DDI-75953",
"R-DDI-76042",
"R-DDI-9018519",
"R-DME-674695",
"R-DME-6807505",
"R-DME-73776",
"R-DME-73779",
"R-DME-75953",
"R-DME-76042",
"R-DME-9018519",
"R-HSA-167161",
"R-HSA-167162",
"R-HSA-167172",
"R-HSA-674695"... | [
"REACTOME:R-DDI-674695",
"REACTOME:R-DDI-6807505",
"REACTOME:R-DDI-73776",
"REACTOME:R-DDI-73779",
"REACTOME:R-DDI-75953",
"REACTOME:R-DDI-76042",
"REACTOME:R-DDI-9018519",
"REACTOME:R-DME-674695",
"REACTOME:R-DME-6807505",
"REACTOME:R-DME-73776",
"REACTOME:R-DME-73779",
"REACTOME:R-DME-75953"... | 52 | [
"1nh2",
"1nvp",
"1rm1",
"1ytf",
"5fmf",
"5fur",
"5fyw",
"5fz5",
"5iy6",
"5iy7",
"5iy8",
"5iy9",
"5iya",
"5iyb",
"5iyc",
"5iyd",
"5m4s",
"5oqj",
"5oqm",
"5sva",
"6gyk",
"6gyl",
"6gym",
"6mzm",
"6o9l",
"7edx",
"7eg7",
"7eg8",
"7eg9",
"7ega",
"7egb",
"7egc"... | 86 | [
"PUB00007709",
"PUB00013248",
"PUB00013320"
] | [
"11089979",
"12818428",
"8610010"
] | [
"A transcription reinitiation intermediate that is stabilized by activator.",
"TFIIA abrogates the effects of inhibition by HMGB1 but not E1A during the early stages of assembly of the transcriptional preinitiation complex.",
"Crystal structure of a yeast TFIIA/TBP/DNA complex."
] | [
2000,
2003,
1996
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Penaeus monodon majanivirus A"
] | [
6301,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
17,
1,
5,
3,
10,
6,
1,
3,
7,
1,
1,
12
] | 12 | true | Family | Transcription factor IIA, alpha/beta subunit | Transcription factor IIA, alpha/beta subunit | TFIIA_asu/bsu | 3 |
IPR004856 | 4,856 | Glycosyl transferase, ALG6/ALG8 | Glyco_trans_ALG6/ALG8 | Family | 9,570 | false | false | N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid (dolichol phosphate)-linked oligosaccharide is assembled at the endoplasmic reticulum membrane prior to the transfer of the oligosaccharide moiety to the target asparagine residues. This olig... | [
"GO:0016758"
] | [
"hexosyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF03155",
"PTHR12413"
] | [
"Alg6_Alg8",
""
] | [
9569,
9326
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.1.265",
"R-CEL-446193",
"R-DDI-446193",
"R-DME-446193",
"R-HSA-446193",
"R-HSA-4724289",
"R-HSA-4724325",
"R-MMU-446193",
"R-RNO-446193",
"R-SCE-446193",
"R-SPO-446193"
] | [
"EC:2.4.1.265",
"REACTOME:R-CEL-446193",
"REACTOME:R-DDI-446193",
"REACTOME:R-DME-446193",
"REACTOME:R-HSA-446193",
"REACTOME:R-HSA-4724289",
"REACTOME:R-HSA-4724325",
"REACTOME:R-MMU-446193",
"REACTOME:R-RNO-446193",
"REACTOME:R-SCE-446193",
"REACTOME:R-SPO-446193"
] | 11 | [
"6snh",
"6sni"
] | 2 | [
"PUB00007710",
"PUB00007711"
] | [
"8016100",
"10359825"
] | [
"New phenotype of mutations deficient in glucosylation of the lipid-linked oligosaccharide: cloning of the ALG8 locus.",
"A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic."
] | [
1994,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanoplasma termitum",
"Eukaryota"
] | [
18,
1,
9551
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
2,
6,
3,
39,
5,
2,
7,
13,
2,
2,
23
] | 12 | true | Family | Glycosyl transferase, ALG6/ALG8 | Glycosyl transferase, ALG6/ALG8 | Glyco_trans_ALG6/ALG8 | 5 |
IPR004858 | 4,858 | Multigene family 505 | MGF_505 | Family | 389 | false | false | This entry represents multigene family 505 proteins from African swine fever virus (ASFV) viruses. Members have been have been connected with ASFV host range specificity, blocking of the host innate response, and virus virulence [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03158"
] | [
"DUF249"
] | [
389
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00078076"
] | [
"25810553"
] | [
"African Swine Fever Virus Georgia Isolate Harboring Deletions of MGF360 and MGF505 Genes Is Attenuated in Swine and Confers Protection against Challenge with Virulent Parental Virus."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Nucleocytoviricota"
] | [
389
] | 1 | [] | [] | 0 | true | Family | Multigene family 505 | Multigene family 505 | MGF_505 | 2 |
IPR004859 | 4,859 | Xrn1, N-terminal | Xrn1_N | Domain | 13,116 | false | false | This is the N-terminal domain of 5'-3' exoribonuclease 1/2 (Xrn1/2) , which may be necessary for 5'-3' exonuclease function. | [
"GO:0003676",
"GO:0004527"
] | [
"nucleic acid binding",
"exonuclease activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF03159"
] | [
"XRN_N"
] | [
13116
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.13.-",
"R-GGA-6791226",
"R-HSA-390471",
"R-HSA-430039",
"R-HSA-450385",
"R-HSA-450513",
"R-HSA-6791226",
"R-HSA-9930044",
"R-MMU-450385",
"R-MMU-450513",
"R-MMU-6791226",
"R-SCE-450385",
"R-SCE-450513"
] | [
"EC:3.1.13.-",
"REACTOME:R-GGA-6791226",
"REACTOME:R-HSA-390471",
"REACTOME:R-HSA-430039",
"REACTOME:R-HSA-450385",
"REACTOME:R-HSA-450513",
"REACTOME:R-HSA-6791226",
"REACTOME:R-HSA-9930044",
"REACTOME:R-MMU-450385",
"REACTOME:R-MMU-450513",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-450385",
... | 13 | [
"2y35",
"3fqd",
"3pie",
"3pif",
"5fir",
"6q8y",
"7opk",
"8jch",
"8k5p",
"8q6v",
"8qsz",
"8yf5",
"8yfe",
"8yfq",
"8yfr",
"9dso",
"9e70",
"9exs",
"9fms"
] | 19 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
12735,
124,
257
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
15,
2,
6,
4,
9,
6,
2,
22,
9,
2,
2,
45
] | 12 | true | Domain | Xrn1, N-terminal | Xrn1, N-terminal | Xrn1_N | 3 |
IPR004860 | 4,860 | Homing endonuclease, LAGLIDADG domain | LAGLIDADG_dom | Domain | 16,024 | false | false | Homing endonucleases (HEnases) form a large and highly diverse class of proteins encoded by introns and inteins that confer mobility to their host genetic elements. LAGLIDADG HEnases are structured into two tandemly repeated homing endonuclease-like domains [ , ]. This entry represents the homing endonuclease LAGLIDADG... | [
"GO:0004519"
] | [
"endonuclease activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PFAM",
"PFAM"
] | [
"PF00961",
"PF03161",
"PF14528"
] | [
"LAGLIDADG_1",
"LAGLIDADG_2",
"LAGLIDADG_3"
] | [
6053,
2666,
7393
] | 3 | [
"REACTOME"
] | [
"R-SCE-611105"
] | [
"REACTOME:R-SCE-611105"
] | 1 | [
"1af5",
"1b24",
"1bp7",
"1dq3",
"1g9y",
"1g9z",
"1m5x",
"1mow",
"1n3e",
"1n3f",
"1p8k",
"1r7m",
"1t9i",
"1t9j",
"1u0c",
"1u0d",
"2ab5",
"2cw7",
"2cw8",
"2dch",
"2ex5",
"2fld",
"2i3p",
"2i3q",
"2o7m",
"2qoj",
"2vbj",
"2vbl",
"2vbn",
"2vbo",
"2vs7",
"2vs8"... | 144 | [
"PUB00004482",
"PUB00044539",
"PUB00075472"
] | [
"9358175",
"17603302",
"8918801"
] | [
"Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family.",
"Bacterial DUF199/COG1481 proteins including sporulation regulator WhiA are distant homologs of LAGLIDADG homing endonucleases th... | [
1997,
2007,
1996
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1389,
6485,
7169,
448,
533
] | 5 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
5,
6,
1,
9,
2,
2
] | 6 | true | Domain | Homing endonuclease, LAGLIDADG domain | Homing endonuclease, LAGLIDADG domain | LAGLIDADG_dom | 1 |
IPR004861 | 4,861 | Atypical dual-specificity phosphatase Siw14-like | Siw14-like | Family | 6,895 | false | false | This group of atypical dual-specificity phosphatases are predominantly from fungi, plants and bacteria. This entry includes budding yeast Siw14 (also known as Oca3) and related proteins. Siw14 is a inositol pyrophosphate phosphatase that modulates inositol pyrophosphate metabolism by dephosphorylating the IP7 isoform 5... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03162"
] | [
"Y_phosphatase2"
] | [
6895
] | 1 | [] | [] | [] | 0 | [
"1xri",
"2m3v",
"2q47",
"4r0s",
"4r0t",
"6byf",
"6e3b",
"7mod",
"7moe",
"7mof",
"7mog",
"7moh",
"7moi",
"7moj",
"7mok",
"7mol",
"7mom"
] | 17 | [
"PUB00078743",
"PUB00088170",
"PUB00088172",
"PUB00151104"
] | [
"19543378",
"26828065",
"21409566",
"20946878"
] | [
"Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885).",
"A Novel Inositol Pyrophosphate Phosphatase in Saccharomyces cerevisiae: Siw14 PROTEIN SELECTIVELY CLEAVES THE β-PHOSPHATE FROM 5-DIPHOSPHOINOSITOL PENTAKISPHOSPH... | [
2009,
2016,
2011,
2010
] | 4 | [] | [
"IPR020428"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"ecological metagenomes",
"uncultured Caudovirales phage"
] | [
619,
6267,
8,
1
] | 4 | [
"Arabidopsis thaliana",
"Homo sapiens",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
29,
1,
1,
12,
5,
1,
27
] | 7 | true | Family | Atypical dual-specificity phosphatase Siw14-like | Atypical dual-specificity phosphatase Siw14-like | Siw14-like | 9 |
IPR004865 | 4,865 | HSR domain | HSR_dom | Domain | 3,281 | false | false | The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerisation domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, ter... | [
"GO:0005634"
] | [
"nucleus"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PROFILE"
] | [
"PF03172",
"PS51414"
] | [
"HSR",
"HSR"
] | [
3267,
3123
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3108214",
"R-HSA-877300",
"R-MMU-3108214"
] | [
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-877300",
"REACTOME:R-MMU-3108214"
] | 3 | [] | 0 | [
"PUB00005483",
"PUB00010341",
"PUB00042671",
"PUB00072610"
] | [
"9697411",
"10049735",
"10212234",
"24275490"
] | [
"The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor.",
"Isolation and characterization of the mouse Aire gene.",
"The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modifi... | [
1998,
1999,
1999,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
8,
3273
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
19,
25,
52,
31
] | 4 | true | Domain | HSR domain | HSR domain | HSR_dom | 7 |
IPR004867 | 4,867 | Chitobiase C-terminal domain | CHB_C_dom | Domain | 2,244 | false | false | E or "early" set domains are associated with the catalytic domain of chitobiase and beta-hexosaminidases ( ) at the C terminus. Chitobiase digests the beta, 1-4 glycosidic bonds of the N-acetylglucosamine (NAG) oligomers found in chitin, an important structural element of fungal cell wall and arthropod exoskeletons. It... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF03174",
"cd02847"
] | [
"CHB_HEX_C",
"E_set_Chitobiase_C"
] | [
2231,
1797
] | 2 | [
"CAZY",
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"GH20",
"3.2.1.52",
"PWY-6902",
"PWY-7822",
"PWY-7883"
] | [
"CAZY:GH20",
"EC:3.2.1.52",
"METACYC:PWY-6902",
"METACYC:PWY-7822",
"METACYC:PWY-7883"
] | 5 | [
"1c7s",
"1c7t",
"1qba",
"1qbb"
] | 4 | [
"PUB00007713",
"PUB00021290"
] | [
"8673609",
"10884356"
] | [
"Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease.",
"Structures of chitobiase mutants complexed with the substrate Di-N-acetyl-d-glucosamine: the catalytic role of the conserved acidic pair, aspartate 539 and glutamate 540."
] | [
1996,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1962,
272,
10
] | 3 | [] | [] | 0 | true | Domain | Chitobiase C-terminal domain | Chitobiase C-terminal domain | CHB_C_dom | 1 |
IPR004868 | 4,868 | DNA-directed DNA polymerase, family B, mitochondria/virus | DNA-dir_DNA_pol_B_mt/vir | Domain | 9,984 | false | false | This entry is found in DNA polymerase type B proteins. Proteins in this entry are found in plant and fungal mitochondria, and in viruses. | [
"GO:0000166",
"GO:0003677",
"GO:0003887",
"GO:0006260"
] | [
"nucleotide binding",
"DNA binding",
"DNA-directed DNA polymerase activity",
"DNA replication"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 4 | [
"PFAM"
] | [
"PF03175"
] | [
"DNA_pol_B_2"
] | [
9984
] | 1 | [
"EC"
] | [
"2.7.7.7"
] | [
"EC:2.7.7.7"
] | 1 | [
"1xhx",
"1xhz",
"1xi1",
"2ex3",
"2py5",
"2pyj",
"2pyl",
"2pzs"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
32,
120,
7273,
2278,
281
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Zea mays"
] | [
1,
2,
7
] | 3 | true | Domain | DNA-directed DNA polymerase, family B, mitochondria/virus | DNA-directed DNA polymerase, family B, mitochondria/virus | DNA-dir_DNA_pol_B_mt/vir | 9 |
IPR004869 | 4,869 | Membrane transport protein MMPL domain | MMPL_dom | Domain | 57,875 | false | false | This entry represents a domain found in the MmpL family of membrane transport proteins. Many of the proteins contain two copies of this aligned region. Some members have been characterised, for instance, Mycobacterium tuberculosis MMPL10 is required for the biosynthesis of polyacyltrehalose (PAT) and the transport of d... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF03176"
] | [
"MMPL"
] | [
57875
] | 1 | [
"REACTOME"
] | [
"R-MTU-9635470"
] | [
"REACTOME:R-MTU-9635470"
] | 1 | [
"5khn",
"5khs",
"6ajf",
"6ajg",
"6ajh",
"6aji",
"6ajj",
"6n40",
"6or2",
"6wu0",
"6xe6",
"7c2m",
"7c2n",
"7e2g",
"7e2h",
"7e2i",
"7fif",
"7k7m",
"7k8a",
"7k8b",
"7k8c",
"7k8d",
"7n6b",
"7nvh",
"7rph",
"7rpi",
"7rpj",
"7rpk",
"7wnx",
"8qkk",
"8zkp",
"8zkq"... | 45 | [
"PUB00066028",
"PUB00077564"
] | [
"23431276",
"25124040"
] | [
"Discovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis.",
"Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis."
] | [
2013,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
1742,
52446,
2459,
2,
1226
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
4,
1,
5
] | 5 | true | Domain | Membrane transport protein MMPL domain | Membrane transport protein MMPL domain | MMPL_dom | 7 |
IPR004870 | 4,870 | Nucleoporin, Nup155-like | Nucleoporin_Nup155 | Family | 5,666 | false | false | This is a family of nucleoporin proteins (Nups). Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells, and mediate bidirectional nucleocytoplasmic transport, especially of mRNA and proteins. Two subsets of nucleoporins that contain peptide repeats have been identified: one is characteris... | [
"GO:0017056",
"GO:0006913",
"GO:0005643"
] | [
"structural constituent of nuclear pore",
"nucleocytoplasmic transport",
"nuclear pore"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PANTHER"
] | [
"PTHR10350"
] | [
""
] | [
5666
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-DME-9615933",
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R... | [
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME:R-DME-4615885",
"REACTOME:R-DME-5578749",
"REACTOME:R-D... | 89 | [
"3i5p",
"3i5q",
"4mhc",
"5a9q",
"5hax",
"5hay",
"5haz",
"5hb0",
"5hb1",
"5ijn",
"5ijo",
"7eye",
"7eyf",
"7eyq",
"7fik",
"7n85",
"7n9f",
"7per",
"7r1y",
"7r5j",
"7r5k",
"7tbi",
"7tbj",
"7tbk",
"7tbl",
"7tbm",
"7tdz",
"7wb4",
"7wkk",
"7woo",
"7wot",
"8tj5"... | 34 | [
"PUB00014159"
] | [
"14517296"
] | [
"Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5666
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
3,
2,
1,
4,
10,
1,
5,
3,
2,
1,
90
] | 12 | true | Family | Nucleoporin, Nup155-like | Nucleoporin, Nup155-like | Nucleoporin_Nup155 | 1 |
IPR004871 | 4,871 | RSE1/DDB1/CPSF1, C-terminal | RSE1/DDB1/CPSF1_C | Domain | 16,991 | false | false | This entry represents the C-terminal in RSE1/SF3B3/DDB1/CPSF1/CFT1 proteins from eukaryotes. RSE1/SF3B3/DDB1/CPSF1/CFT1 proteins share a domain architecture consisting of three β-propellers. They have diverse functions, primarily related to RNA/DNA binding. Pre-mRNA-splicing factor RSE1 plays an important role in the s... | [
"GO:0003676",
"GO:0005634"
] | [
"nucleic acid binding",
"nucleus"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF03178"
] | [
"CPSF_A"
] | [
16991
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-72163",
"R-BTA-72165",
"R-CEL-110314",
"R-CEL-5696394",
"R-CEL-5696395",
"R-CEL-5696400",
"R-CEL-6781823",
"R-CEL-6782135",
"R-CEL-6782210",
"R-CEL-72187",
"R-CEL-72203",
"R-CEL-73856",
"R-CEL-77595",
"R-CEL-8951664",
"R-DDI-110314",
"R-DDI-5696394",
"R-DDI-5696395",
"R-DDI-... | [
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72165",
"REACTOME:R-CEL-110314",
"REACTOME:R-CEL-5696394",
"REACTOME:R-CEL-5696395",
"REACTOME:R-CEL-5696400",
"REACTOME:R-CEL-6781823",
"REACTOME:R-CEL-6782135",
"REACTOME:R-CEL-6782210",
"REACTOME:R-CEL-72187",
"REACTOME:R-CEL-72203",
"REACTOME:R-CEL-7... | 86 | [
"2b5l",
"2b5m",
"2hye",
"3e0c",
"3ei1",
"3ei2",
"3ei3",
"3ei4",
"3i7h",
"3i7k",
"3i7l",
"3i7n",
"3i7o",
"3i7p",
"3i89",
"3i8c",
"3i8e",
"4a08",
"4a09",
"4a0a",
"4a0b",
"4a0k",
"4a0l",
"4a11",
"4ci1",
"4ci2",
"4ci3",
"4e54",
"4e5z",
"4tz4",
"5fqd",
"5gm6"... | 257 | [
"PUB00007715",
"PUB00155537",
"PUB00155538",
"PUB00155539",
"PUB00155540",
"PUB00155541"
] | [
"11421366",
"9819400",
"27185460",
"16940174",
"16407252",
"8929410"
] | [
"The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo.",
"A link between secretion and pre-mRNA processing defects in Saccharomyces cerevisiae and the identification of a novel splicing gene, RSE1.",
"The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila ... | [
2001,
1998,
2016,
2006,
2006,
1996
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Salmonella enterica subsp. diarizonae serovar Rough:r:z",
"bird metagenome"
] | [
16989,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
28,
6,
6,
4,
20,
9,
4,
14,
14,
2,
5,
60
] | 12 | true | Domain | RSE1/DDB1/CPSF1, C-terminal | RSE1/DDB1/CPSF1, C-terminal | RSE1/DDB1/CPSF1_C | 8 |
IPR004872 | 4,872 | Lipoprotein NlpA family | Lipoprotein_NlpA | Family | 29,289 | false | false | This entry represents bacterial lipoproteins that belong to the NlpA family [ ]. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-depen... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PF03180",
"PIRSF002854",
"PTHR30429",
"TIGR00363"
] | [
"Lipoprotein_9",
"MetQ",
"",
""
] | [
29288,
21354,
29141,
7713
] | 4 | [] | [] | [] | 0 | [
"1p99",
"1xs5",
"3gxa",
"3ir1",
"3k2d",
"3tqw",
"3up9",
"4ef1",
"4ef2",
"4got",
"4ib2",
"4k3f",
"4ntl",
"4ote",
"4q5t",
"4qhq",
"4yah",
"6cva",
"6cvl",
"6dzx",
"6jf1",
"6oja",
"7mbz"
] | 23 | [
"PUB00017750",
"PUB00043724",
"PUB00098633",
"PUB00098634"
] | [
"12169620",
"12819857",
"23852867",
"30352853"
] | [
"The metD D-methionine transporter locus of Escherichia coli is an ABC transporter gene cluster.",
"A transporter of Escherichia coli specific for L- and D-methionine is the prototype for a new family within the ABC superfamily.",
"Synthetic effect between envelope stress and lack of outer membrane vesicle prod... | [
2002,
2003,
2013,
2018
] | 4 | [] | [] | 0 | 0 | null | [
"Archaeoglobus",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
6,
29088,
31,
1,
163
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Lipoprotein NlpA family | Lipoprotein NlpA family | Lipoprotein_NlpA | 6 |
IPR004873 | 4,873 | BURP domain | BURP_dom | Domain | 7,155 | false | false | The BURP domain was named after the proteins in which it was first identified: BNM2, USP, RD22, and PG1beta. It is found in the C terminus of a number of plant cell wall proteins, which are defined not only by the BURP domain, but also by the overall similarity in their modular construction. The BURP domain-containing ... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF03181",
"PS51277",
"SM01045"
] | [
"BURP",
"BURP",
"BURP"
] | [
7071,
7104,
6666
] | 3 | [] | [] | [] | 0 | [
"8sy2",
"8sy3"
] | 2 | [
"PUB00007716",
"PUB00043785",
"PUB00043786"
] | [
"9790599",
"12172833",
"14612572"
] | [
"A conserved BURP domain defines a novel group of plant proteins with unusual primary structures.",
"SCB1, a BURP-domain protein gene, from developing soybean seed coats.",
"The classical Ubisch bodies carry a sporophytically produced structural protein (RAFTIN) that is essential for pollen development."
] | [
1998,
2002,
2003
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
29,
7124,
2
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
21,
41,
47
] | 3 | true | Domain | BURP domain | BURP domain | BURP_dom | 9 |
IPR004875 | 4,875 | DDE superfamily endonuclease domain | DDE_SF_endonuclease_dom | Domain | 38,622 | false | false | Proteins containing this domain are probably endonucleases of the DDE superfamily. This domain contains three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand tra... | [
"GO:0003676"
] | [
"nucleic acid binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF03184"
] | [
"DDE_1"
] | [
38622
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053389",
"PUB00077575",
"PUB00077576"
] | [
"15487591",
"18072184",
"22404710"
] | [
"Isolation and characterization of a Jerky and JRK/JH8 like gene, tigger transposable element derived 7, TIGD7.",
"Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells.",
"Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation."
] | [
2004,
2008,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Bracoviriform inaniti",
"Eukaryota",
"metagenomes"
] | [
4,
1,
38615,
2
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
9,
24,
22,
25,
1,
3
] | 8 | true | Domain | DDE superfamily endonuclease domain | DDE superfamily endonuclease domain | DDE_SF_endonuclease_dom | 4 |
IPR004876 | 4,876 | Corona nucleocapsid I | Corona_nucI | Family | 160 | false | false | Members of this family are Coronavirus proteins that are located in the nucleocapsid [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03187"
] | [
"Corona_I"
] | [
160
] | 1 | [
"GP"
] | [
"GenProp1009"
] | [
"GP:GenProp1009"
] | 1 | [] | 0 | [
"PUB00085194"
] | [
"8995618"
] | [
"The internal open reading frame within the nucleocapsid gene of mouse hepatitis virus encodes a structural protein that is not essential for viral replication."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Orthocoronavirinae"
] | [
160
] | 1 | [] | [] | 0 | true | Family | Corona nucleocapsid I | Corona nucleocapsid I | Corona_nucI | 5 |
IPR004878 | 4,878 | Otopetrin | Otopetrin | Family | 7,016 | false | false | The otopetrins are a group of proteins evolutionarily conserved among metazoan [ ]. In most vertebrates there are three Otopetrin genes that encode three proteins, OTOP1, OTOP2, and OTOP3. All form proton-selective ion channels that allow influx of protons into cells [ ]. The structure of otopetrin-1 ( ) shows it to ha... | [
"GO:0015252",
"GO:1902600",
"GO:0016020"
] | [
"proton channel activity",
"proton transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF03189",
"PTHR21522"
] | [
"Otopetrin",
""
] | [
6858,
6947
] | 2 | [
"REACTOME"
] | [
"R-HSA-9729555"
] | [
"REACTOME:R-HSA-9729555"
] | 1 | [
"6nf4",
"6nf6",
"6o84",
"8ug4",
"8ug5",
"8ug6",
"8ug7",
"8ug8",
"8uga",
"9mff",
"9mfl",
"9mfm"
] | 12 | [
"PUB00043570",
"PUB00098660",
"PUB00098661",
"PUB00098662",
"PUB00098663",
"PUB00098664",
"PUB00098665",
"PUB00100685"
] | [
"18254951",
"29371428",
"12651873",
"31543264",
"31160780",
"30973323",
"17606897",
"31543453"
] | [
"Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members.",
"An evolutionarily conserved gene family encodes proton-selective ion channels.",
"Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by... | [
2008,
2018,
2003,
2019,
2019,
2019,
2007,
2019
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7016
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
5,
14,
4,
7,
7
] | 6 | true | Family | Otopetrin | Otopetrin | Otopetrin | 4 |
IPR004879 | 4,879 | Spermatogenesis-associated protein 20-like, TRX domain | Ssp411-like_TRX | Domain | 14,733 | false | false | This entry represents the TRX domain found in highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length. This domain contains a redox active CXXC motif. The human/rat protein, called Spermatogenesis-associated protein 20 (SSP411), is specifically expressed in the testis ... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF03190",
"cd02955"
] | [
"Thioredox_DsbH",
"SSP411"
] | [
14733,
12436
] | 2 | [] | [] | [] | 0 | [
"3ira",
"7tkv"
] | 2 | [
"PUB00056144"
] | [
"15223837"
] | [
"Cloning and characterization of rat spermatid protein SSP411: a thioredoxin-like protein."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
990,
9367,
3997,
379
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
8,
1,
3,
2,
7,
1,
1,
1,
6,
6
] | 10 | true | Domain | Spermatogenesis-associated protein 20-like, TRX domain | Spermatogenesis-associated protein 20-like, TRX domain | Ssp411-like_TRX | 6 |
IPR004881 | 4,881 | Ribosome biogenesis GTPase RsgA | Ribosome_biogen_GTPase_RsgA | Family | 27,505 | false | false | This entry contains Escherichia coli (strain K12) RsgA, which plays a role in the late maturation steps of the functional core of the 30S ribosomal subunit. It removes RbfA from mature, but not immature, 30S ribosomes in a GTP-dependent manner [ , ], and binds the 30S subunit making contact with the head, platform and ... | [
"GO:0003924",
"GO:0005525"
] | [
"GTPase activity",
"GTP binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"HAMAP",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_01820",
"PTHR32120",
"TIGR00157",
"cd01854"
] | [
"GTPase_RsgA",
"",
"",
"YjeQ_EngC"
] | [
25311,
27498,
26825,
26875
] | 4 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.6.1.-",
"GenProp0802",
"PWY-5757",
"PWY-6147",
"PWY-6383",
"PWY-6797",
"PWY-7206",
"PWY-7419",
"PWY-7539",
"PWY-7719",
"PWY-7821",
"PWY-8289"
] | [
"EC:3.6.1.-",
"GP:GenProp0802",
"METACYC:PWY-5757",
"METACYC:PWY-6147",
"METACYC:PWY-6383",
"METACYC:PWY-6797",
"METACYC:PWY-7206",
"METACYC:PWY-7419",
"METACYC:PWY-7539",
"METACYC:PWY-7719",
"METACYC:PWY-7821",
"METACYC:PWY-8289"
] | 12 | [
"1t9h",
"1u0l",
"2rcn",
"2ykr",
"2yv5",
"4a2i",
"5no2",
"5no3",
"5no4",
"5uz4",
"6h4d",
"6zhl",
"6zhm",
"6zjo",
"7boi",
"7nar"
] | 16 | [
"PUB00015323",
"PUB00017375",
"PUB00053979",
"PUB00076461",
"PUB00081044",
"PUB00083883",
"PUB00083884",
"PUB00085159"
] | [
"14973029",
"15466596",
"15828870",
"21788480",
"21960487",
"21102555",
"25904134",
"15266054"
] | [
"Studies of the interaction of Escherichia coli YjeQ with the ribosome in vitro.",
"A novel GTPase activated by the small subunit of ribosome.",
"Characterization of the Bacillus subtilis GTPase YloQ and its role in ribosome function.",
"Structural basis for the function of a small GTPase RsgA on the 30S ribo... | [
2004,
2004,
2005,
2011,
2011,
2011,
2015,
2004
] | 8 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
89,
26139,
818,
459
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
1,
2,
4
] | 4 | true | Family | Ribosome biogenesis GTPase RsgA | Ribosome biogenesis GTPase RsgA | Ribosome_biogen_GTPase_RsgA | 8 |
IPR004882 | 4,882 | Luc7-related | Luc7-rel | Family | 10,360 | false | false | This family consists of several Luc7 protein homologues that are restricted to eukaryotes. In budding yeast, Luc7 is an essential subunit of the yeast U1 snRNP, which forms the spliceosomal commitment complex with other proteins that targets pre-mRNA to the splicing pathway [ , ]. Its N-terminal zinc finger has been fo... | [
"GO:0003729",
"GO:0006376",
"GO:0005685"
] | [
"mRNA binding",
"mRNA splice site recognition",
"U1 snRNP"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF03194",
"PTHR12375"
] | [
"LUC7",
""
] | [
10343,
10208
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-72163",
"R-HSA-72163",
"R-MMU-72163"
] | [
"REACTOME:R-BTA-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163"
] | 3 | [
"5zwn",
"6g90",
"6n7p",
"6n7r",
"7oqc",
"7oqe",
"8w2o"
] | 7 | [
"PUB00016922",
"PUB00016923",
"PUB00067981"
] | [
"11170747",
"10500099",
"17726058"
] | [
"Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain.",
"Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition.",
"The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human."
] | [
2001,
1999,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
10360
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
25,
6,
14,
2,
20,
13,
1,
13,
15,
1,
1,
70
] | 12 | true | Family | Luc7-related | Luc7-related | Luc7-rel | 1 |
IPR004883 | 4,883 | Lateral organ boundaries, LOB | LOB | Domain | 21,158 | false | false | The lateral organ boundaries (LOB) gene is expressed at the adaxial base of initiating lateral organs and encodes a plant-specific protein of unknown function. The N-terminal one half of the LOB protein contains a conserved approximately 100-amino acid domain (the LOB domain) that is present in 42 other Arabidopsis tha... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF03195",
"PS50891"
] | [
"LOB",
"LOB"
] | [
21144,
20822
] | 2 | [
"PROSITEDOC"
] | [
"PDOC50891"
] | [
"PROSITEDOC:PDOC50891"
] | 1 | [
"5ly0"
] | 1 | [
"PUB00018358"
] | [
"12068116"
] | [
"The lateral organ boundaries gene defines a novel, plant-specific gene family."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
21158
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
133,
105,
121
] | 3 | true | Domain | Lateral organ boundaries, LOB | Lateral organ boundaries, LOB | LOB | 1 |
IPR004884 | 4,884 | Protein of unknown function DUF261 | DUF261 | Family | 289 | false | false | This is a group of proteins of unknown function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03196"
] | [
"DUF261"
] | [
289
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Spirochaetales",
"Trichomonas vaginalis (strain ATCC PRA-98 / G3)"
] | [
286,
3
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF261 | Protein of unknown function DUF261 | DUF261 | 9 |
IPR004885 | 4,885 | Frd-Gp32-like | Frd-Gp32-like | Family | 248 | false | false | This is a group of bacteriophage proteins that has no known function. It includes Uncharacterized 14.7 kDa protein in frd-Gp32 intergenic region from Enterobacteria phage T4 and similar proteins from related phages. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03197"
] | [
"FRD2"
] | [
248
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
248
] | 1 | [] | [] | 0 | true | Family | Frd-Gp32-like | Frd-Gp32-like | Frd-Gp32-like | 2 |
IPR004886 | 4,886 | Glucanosyltransferase | Glucanosyltransferase | Family | 8,016 | false | false | This is a family of yeast glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferases [ ]. It includes Candida albicans pH-regulated protein PHR1, which is required for apical growth and plays a role in morphogenesis [ ] and Saccharomyces cerevisiae glycolipid anchored surface protein Gas1-5 [ ]. Gas1 is a be... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF03198",
"PTHR31468"
] | [
"Glyco_hydro_72",
""
] | [
7930,
7918
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.4.1.-",
"PWY-1901",
"PWY-1961",
"PWY-1981",
"PWY-2021",
"PWY-2881",
"PWY-2901",
"PWY-2902",
"PWY-4421",
"PWY-4801",
"PWY-5094",
"PWY-5105",
"PWY-5129",
"PWY-5139",
"PWY-5160",
"PWY-5161",
"PWY-5268",
"PWY-5284",
"PWY-5286",
"PWY-5310",
"PWY-5312",
"PWY-5313",
"PWY-5317... | [
"EC:2.4.1.-",
"METACYC:PWY-1901",
"METACYC:PWY-1961",
"METACYC:PWY-1981",
"METACYC:PWY-2021",
"METACYC:PWY-2881",
"METACYC:PWY-2901",
"METACYC:PWY-2902",
"METACYC:PWY-4421",
"METACYC:PWY-4801",
"METACYC:PWY-5094",
"METACYC:PWY-5105",
"METACYC:PWY-5129",
"METACYC:PWY-5139",
"METACYC:PWY-5... | 200 | [
"2w61",
"2w62",
"2w63",
"5fih",
"5o9o",
"5o9p",
"5o9q",
"5o9r",
"5o9y",
"5oa2",
"5oa6",
"8pe1",
"8pe2"
] | 13 | [
"PUB00019628",
"PUB00019629",
"PUB00057441",
"PUB00076879",
"PUB00076880"
] | [
"1824714",
"7823929",
"10769178",
"24532730",
"19541632"
] | [
"Determinants for glycophospholipid anchoring of the Saccharomyces cerevisiae GAS1 protein to the plasma membrane.",
"PHR1, a pH-regulated gene of Candida albicans, is required for morphogenesis.",
"Identification of the catalytic residues of the first family of beta(1-3)glucanosyltransferases identified in fun... | [
1991,
1995,
2000,
2014,
2009
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
46,
7970
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
5,
5,
4,
1
] | 4 | true | Family | Glucanosyltransferase | Glucanosyltransferase | Glucanosyltransferase | 5 |
IPR004887 | 4,887 | Glutathione synthase, substrate-binding domain | GSH_synth_subst-bd | Domain | 6,101 | false | false | This entry represents the substrate-binding domain of glutathione synthetase ( ) (GSS), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step being catalysed b... | [
"GO:0004363",
"GO:0005524",
"GO:0006750"
] | [
"glutathione synthase activity",
"ATP binding",
"glutathione biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF03199"
] | [
"GSH_synthase"
] | [
6101
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.3.2.3",
"PWY-8043",
"R-DDI-174403",
"R-HSA-174403",
"R-HSA-5579006",
"R-MMU-174403",
"R-RNO-174403",
"R-SCE-174403",
"R-SPO-174403"
] | [
"EC:6.3.2.3",
"METACYC:PWY-8043",
"REACTOME:R-DDI-174403",
"REACTOME:R-HSA-174403",
"REACTOME:R-HSA-5579006",
"REACTOME:R-MMU-174403",
"REACTOME:R-RNO-174403",
"REACTOME:R-SCE-174403",
"REACTOME:R-SPO-174403"
] | 9 | [
"1m0t",
"1m0w",
"2hgs",
"2wyo",
"3kaj",
"3kak",
"3kal",
"5oes",
"5oeu",
"5oev",
"8fbz"
] | 11 | [
"PUB00019656",
"PUB00035960"
] | [
"10369661",
"15981742"
] | [
"Molecular basis of glutathione synthetase deficiency and a rare gene permutation event.",
"Physiological and pathological aspects of GSH metabolism."
] | [
1999,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
243,
5853,
5
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
4,
7,
7,
2,
14,
6,
1,
1,
18
] | 12 | true | Domain | Glutathione synthase, substrate-binding domain | Glutathione synthase, substrate-binding domain | GSH_synth_subst-bd | 9 |
IPR004888 | 4,888 | Glycoside hydrolase family 63 | Glycoside_hydrolase_63 | Family | 15,154 | false | false | This family of enzymes belongs to glycosyl hydrolase family 63 ( ). They catalyse the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase is the first enzyme in the N-linked oligosaccharide processing pathway. This family also includes glucosyl... | [
"GO:0004573",
"GO:0009311"
] | [
"Glc3Man9GlcNAc2 oligosaccharide glucosidase activity",
"oligosaccharide metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR10412"
] | [
""
] | [
15154
] | 1 | [
"CAZY",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GH63",
"3.2.1",
"R-HSA-4793954",
"R-HSA-532668",
"R-HSA-9683686",
"R-HSA-9694548",
"R-HSA-9768727",
"R-MMU-9768727",
"R-RNO-9768727"
] | [
"CAZY:GH63",
"EC:3.2.1",
"REACTOME:R-HSA-4793954",
"REACTOME:R-HSA-532668",
"REACTOME:R-HSA-9683686",
"REACTOME:R-HSA-9694548",
"REACTOME:R-HSA-9768727",
"REACTOME:R-MMU-9768727",
"REACTOME:R-RNO-9768727"
] | 9 | [
"2z07",
"4j5t",
"4wva",
"4wvb",
"4wvc",
"5mhf",
"5ohc",
"5ohz",
"5oi0",
"5oi1",
"5oie",
"5oiv",
"5oiw",
"5oj4",
"5oju",
"5ojv",
"5ont",
"5onz",
"5oo2",
"6g3n",
"6q5t",
"7r6j",
"7rd2",
"7rev",
"7t66",
"7t68",
"7t6w",
"7t8v",
"8e3j",
"8e3p",
"8e4i",
"8e4k"... | 53 | [
"PUB00004870",
"PUB00005266",
"PUB00094228"
] | [
"7624375",
"8535779",
"31316802"
] | [
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases.",
"The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from n... | [
1995,
1995,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"metagenomes"
] | [
42,
7488,
7541,
1,
82
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
2,
3,
3,
15,
5,
3,
4,
3,
2,
1,
24
] | 12 | true | Family | Glycoside hydrolase family 63 | Glycoside hydrolase family 63 | Glycoside_hydrolase_63 | 1 |
IPR004889 | 4,889 | H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, C-terminal | HMD_C | Domain | 155 | false | false | This entry represents the C-terminal domain of H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenases. The N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase system of methanogenic archaea is composed of H2-forming methylenetetrahydromethanopterin dehydrogenase (Hmd, represented by this entry) and F4... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03201"
] | [
"HMD"
] | [
155
] | 1 | [
"EC",
"METACYC"
] | [
"1.12.98.2",
"PWY-7784"
] | [
"EC:1.12.98.2",
"METACYC:PWY-7784"
] | 2 | [
"2b0j",
"3daf",
"3dag",
"3f46",
"3f47",
"3h65",
"4jjf",
"4jjg",
"4yt2",
"4yt4",
"4yt5",
"4yt8",
"5ok4",
"6ggu",
"6hac",
"6hae",
"6hav",
"6hux",
"6huy",
"6huz",
"6yk9",
"6yka",
"6ykb"
] | 23 | [
"PUB00013473",
"PUB00014604",
"PUB00014605",
"PUB00016833",
"PUB00088210"
] | [
"11081790",
"8215796",
"9151968",
"15506791",
"26094576"
] | [
"Regulation of the synthesis of H2-forming methylenetetrahydromethanopterin dehydrogenase (Hmd) and of HmdII and HmdIII in Methanothermobacter marburgensis.",
"Two N5,N10-methylenetetrahydromethanopterin dehydrogenases in the extreme thermophile Methanopyrus kandleri: characterization of the coenzyme F420-depende... | [
2000,
1993,
1997,
2004,
2015
] | 5 | [] | [] | 0 | 0 | null | [
"Desulfurobacterium",
"Methanobacteriota",
"bioreactor metagenome"
] | [
6,
148,
1
] | 3 | [] | [] | 0 | true | Domain | H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, C-terminal | H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, C-terminal | HMD_C | 4 |
IPR004890 | 4,890 | Mycoplasma lipoprotein, C-terminal | Lipoprotein_10_C | Domain | 352 | false | false | This domain is found along with a central domain ( ) in a group of Mycoplasma lipoproteins of unknown function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03202"
] | [
"Lipoprotein_10"
] | [
352
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mycoplasmatota"
] | [
352
] | 1 | [] | [] | 0 | true | Domain | Mycoplasma lipoprotein, C-terminal | Mycoplasma lipoprotein, C-terminal | Lipoprotein_10_C | 5 |
IPR004891 | 4,891 | Mercury transport protein MerC | Mercury-R_MerC | Family | 3,686 | false | false | The mercury resistance protein, MerC, is an inner membrane protein that mediates Hg 2+ transport into the cytoplasm [ , ]. MerA then converts the inorganic form of mercury Hg2+ to the less toxic form Hg0, thereby conferring mercury resistance [ ]. | [
"GO:0015097",
"GO:0015694",
"GO:0016020"
] | [
"mercury ion transmembrane transporter activity",
"mercury ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF03203"
] | [
"MerC"
] | [
3686
] | 1 | [
"GP"
] | [
"GenProp0151"
] | [
"GP:GenProp0151"
] | 1 | [] | 0 | [
"PUB00019848",
"PUB00088043",
"PUB00088045"
] | [
"11116334",
"23985830",
"28966143"
] | [
"The quality of merC, a module of the mer mosaic.",
"Role of MerC, MerE, MerF, MerT, and/or MerP in resistance to mercurials and the transport of mercurials in Escherichia coli.",
"Functional efficiency of MerA protein among diverse mercury resistant bacteria for efficient use in bioremediation of inorganic mer... | [
2000,
2013,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
3555,
86,
45
] | 3 | [] | [] | 0 | true | Family | Mercury transport protein MerC | Mercury transport protein MerC | Mercury-R_MerC | 9 |
IPR004893 | 4,893 | Nitrogen fixation protein NifW | NifW | Family | 1,322 | false | false | Nitrogenase is a complex metalloenzyme composed of two proteins designated the Fe-protein and the MoFe-protein. Apart from these two proteins, a number of accessory proteins are essential for the maturation and assembly of nitrogenase. Even though experimental evidence suggests that these accessory proteins are require... | [
"GO:0009399"
] | [
"nitrogen fixation"
] | [
"biological_process"
] | 1 | [
"HAMAP",
"PFAM",
"PIRSF"
] | [
"MF_00529",
"PF03206",
"PIRSF005790"
] | [
"NifW",
"NifW",
"NifW"
] | [
981,
1322,
910
] | 3 | [
"GP"
] | [
"GenProp0029"
] | [
"GP:GenProp0029"
] | 1 | [] | 0 | [
"PUB00007718"
] | [
"9514861"
] | [
"Genetic analysis on the NifW by utilizing the yeast two-hybrid system revealed that the NifW of Azotobacter vinelandii interacts with the NifZ to form higher-order complexes."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Hexamita inflata",
"metagenomes"
] | [
1306,
1,
15
] | 3 | [] | [] | 0 | true | Family | Nitrogen fixation protein NifW | Nitrogen fixation protein NifW | NifW | 1 |
IPR004894 | 4,894 | Borrelia outer surface protein D OspD | OspD | Family | 28 | false | false | This is a family of outer surface proteins from Borrelia. The function of these proteins is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03207"
] | [
"OspD"
] | [
28
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati"
] | [
28
] | 1 | [] | [] | 0 | true | Family | Borrelia outer surface protein D OspD | Borrelia outer surface protein D OspD | OspD | 7 |
IPR004895 | 4,895 | Prenylated rab acceptor PRA1 | Prenylated_rab_accept_PRA1 | Family | 12,807 | false | false | Prenylated Rab acceptor protein 1 (PRA1) family includes PRAF1/2/3 from mammals, Yip3 from budding yeasts and several PRA proteins from plants. In budding yeast, Yip3 interacts with members of the Rab GTPase family and may be involved in transport between the ER and Golgi complex [ ]. In humans, PRAF1 is a general Rab ... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER",
"PANTHER"
] | [
"PF03208",
"PTHR12859",
"PTHR19317"
] | [
"PRA1",
"",
""
] | [
12760,
3200,
8706
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-210500",
"R-HSA-210500",
"R-MMU-210500",
"R-RNO-210500",
"R-SSC-210500"
] | [
"REACTOME:R-BTA-210500",
"REACTOME:R-HSA-210500",
"REACTOME:R-MMU-210500",
"REACTOME:R-RNO-210500",
"REACTOME:R-SSC-210500"
] | 5 | [] | 0 | [
"PUB00033655",
"PUB00068381",
"PUB00068382",
"PUB00068383",
"PUB00068384"
] | [
"11157978",
"12107180",
"10751420",
"17975142",
"12119102"
] | [
"Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex.",
"Disruption of Golgi morphology and trafficking in cells expressing mutant prenylated rab acceptor-1.",
"PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1.",
"Expression of prenylated... | [
2001,
2002,
2000,
2007,
2002
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
12806,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
67,
2,
4,
6,
17,
5,
1,
37,
12,
1,
1,
55
] | 12 | true | Family | Prenylated rab acceptor PRA1 | Prenylated rab acceptor PRA1 | Prenylated_rab_accept_PRA1 | 1 |
IPR004897 | 4,897 | P/V phosphoprotein, paramyxoviral | P/V_Pprotein_paramyxoviral | Family | 2,529 | false | false | Paramyxoviral P genes are able to generate more than one product, using alternative reading frames and RNA editing. The P gene encodes the structural phosphoprotein P. In addition, it encodes several non-structural proteins present in the infected cell but not in the virus particle. This family includes phosphoprotein ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03210"
] | [
"Paramyx_P_V_C"
] | [
2529
] | 1 | [] | [] | [] | 0 | [
"1oks",
"1t6o",
"3bbz",
"3zdo",
"4c5q",
"4eij",
"4gjw",
"4heo",
"4n5b",
"5lxj",
"6eb8",
"6eb9",
"6htl",
"6v85",
"6v86",
"6vag",
"7pno",
"7pon",
"7yot",
"7you",
"7yov",
"8izl",
"8izm",
"8x01",
"8yxm",
"8yxo",
"8yxr",
"8zpv",
"9bdq",
"9cgi",
"9cok",
"9cwo"... | 49 | [
"PUB00007719",
"PUB00007720",
"PUB00020838",
"PUB00031362"
] | [
"11336555",
"8277263",
"12944395",
"15159535"
] | [
"Two regions of the P protein are required to be active with the L protein for human parainfluenza virus type 1 RNA polymerase activity.",
"RNA editing in Newcastle disease virus.",
"Crystal structure of the measles virus phosphoprotein domain responsible for the induced folding of the C-terminal domain of the ... | [
2001,
1993,
2003,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Bifidobacterium breve",
"Paramyxoviridae",
"Plakobranchidae"
] | [
1,
2525,
3
] | 3 | [] | [] | 0 | true | Family | P/V phosphoprotein, paramyxoviral | P/V phosphoprotein, paramyxoviral | P/V_Pprotein_paramyxoviral | 6 |
IPR004898 | 4,898 | Pectate lyase PlyH/PlyE-like | Pectate_lyase_PlyH/PlyE-like | Family | 7,501 | false | false | Pectate lyase is responsible for the maceration and soft-rotting of plant tissue. It catalyses the eliminative cleavage of pectate to produce oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. Pectate lyase is an extracellular enzyme and is induced by pectin. It is subject to sel... | [
"GO:0030570",
"GO:0005576"
] | [
"pectate lyase activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF03211",
"PTHR33407"
] | [
"Pectate_lyase",
""
] | [
7381,
7343
] | 2 | [
"EC"
] | [
"4.2.2.2"
] | [
"EC:4.2.2.2"
] | 1 | [
"1ee6",
"3b4n",
"3b8y",
"3b90",
"3t9g",
"4ew9",
"4u49",
"4u4b",
"4yz0",
"4yza",
"4yzq",
"4yzx",
"4z03",
"4z05",
"4z06"
] | 15 | [
"PUB00079200"
] | [
"16844780"
] | [
"Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2036,
5465
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Pectate lyase PlyH/PlyE-like | Pectate lyase PlyH/PlyE-like | Pectate_lyase_PlyH/PlyE-like | 9 |
IPR004899 | 4,899 | Pertactin, central region | Pertactin_central | Domain | 3,475 | false | false | Bordetella pertussis is a Gram-negative, aerobic coccobacillus that causes pertussis (whooping cough), especially in young children [ ]. Once present in the lungs, the bacterium attaches to ciliated pulmonary epithelial cells via a collection of outer membrane proteins, all of which are virulence factors. Pertactin, or... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03212"
] | [
"Pertactin"
] | [
3475
] | 1 | [
"REACTOME"
] | [
"R-HSA-9760173"
] | [
"REACTOME:R-HSA-9760173"
] | 1 | [
"1dab",
"2iou",
"3h09",
"3syj",
"7akv"
] | 5 | [
"PUB00007646",
"PUB00007647",
"PUB00007648",
"PUB00007649"
] | [
"2542937",
"1527510",
"10943406",
"8609998"
] | [
"Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis.",
"Cloning, nucleotide sequence and heterologous expression of the protective outer-membrane protein P.68 pertactin from Bordetella bronchiseptica.",
"Molecular aspects of Bordetella pertussis pathogenes... | [
1989,
1992,
1999,
1996
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3468,
3,
4
] | 3 | [
"Escherichia coli (strain K12)"
] | [
5
] | 1 | true | Domain | Pertactin, central region | Pertactin, central region | Pertactin_central | 3 |
IPR004900 | 4,900 | Poxvirus P35 | Poxvirus_P35 | Family | 493 | false | false | The Poxvirus P35 protein is an immunodominant envelope protein also known as Envelope protein OPG108. It binds to heparan sulphate on the cell surface to provide virion attachment to target cell [ ]. | [
"GO:0019031"
] | [
"viral envelope"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF03213"
] | [
"Pox_P35"
] | [
493
] | 1 | [] | [] | [] | 0 | [
"5ej0"
] | 1 | [
"PUB00053831"
] | [
"2462305"
] | [
"Molecular characterization of a prominent antigen of the vaccinia virus envelope."
] | [
1988
] | 1 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
493
] | 1 | [] | [] | 0 | true | Family | Poxvirus P35 | Poxvirus P35 | Poxvirus_P35 | 2 |
IPR004901 | 4,901 | Reversibly glycosylated polypeptide | RGP | Family | 2,106 | false | false | This family consists of previously named Reversibly Glycosylated Proteins (RGPs), which are plant-specific cytosolic proteins that tend to associate with the Golgi membranes and have been implicated in polysaccharide biosynthesis [ , , , ]. In Arabidopsis thaliana the RGP protein family consists of five closely related... | [
"GO:0016866",
"GO:0071669"
] | [
"intramolecular transferase activity",
"plant-type cell wall organization or biogenesis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF016429"
] | [
"UPTG"
] | [
2106
] | 1 | [
"EC"
] | [
"5.4.99.30"
] | [
"EC:5.4.99.30"
] | 1 | [
"8cid"
] | 1 | [
"PUB00060596",
"PUB00060597",
"PUB00060598",
"PUB00060599",
"PUB00087322"
] | [
"12011358",
"20149347",
"17182701",
"20057139",
"21478444"
] | [
"Glucosylation activity and complex formation of two classes of reversibly glycosylated polypeptides.",
"An arginyl residue in rice UDP-arabinopyranose mutase is required for catalytic activity and autoglycosylation.",
"A plant mutase that interconverts UDP-arabinofuranose and UDP-arabinopyranose.",
"Purifica... | [
2002,
2010,
2007,
2010,
2011
] | 5 | [
"IPR037595"
] | [] | 1 | 0 | 1 | [
"Viridiplantae"
] | [
2106
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
16,
5,
11
] | 3 | true | Family | Reversibly glycosylated polypeptide | Reversibly glycosylated polypeptide | RGP | 3 |
IPR004902 | 4,902 | Rhabdovirus nucleoprotein | Rhabdo_ncap_2 | Family | 991 | false | false | This is a family of Rhabdovirus nucleocapsid proteins. These proteins undergo phosphorylation. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03216"
] | [
"Rhabdo_ncap_2"
] | [
991
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Grimontia sedimenti",
"Riboviria"
] | [
230,
2,
759
] | 3 | [] | [] | 0 | true | Family | Rhabdovirus nucleoprotein | Rhabdovirus nucleoprotein | Rhabdo_ncap_2 | 1 |
IPR004903 | 4,903 | Lactobacillus surface layer protein | S-layer_prot | Family | 295 | false | false | The bacterial S-layer forms a regular structure, composed of a monolayer of one glycolprotein on the surfaces of many prokaryotic species. S-layers fulfil different functions, such as serving as attachment structures for extracellular enzymes and acting as major virulence determinants for pathogenic species. This entry... | [
"GO:0005199",
"GO:0009274",
"GO:0030115"
] | [
"structural constituent of cell wall",
"peptidoglycan-based cell wall",
"S-layer"
] | [
"molecular_function",
"cellular_component",
"cellular_component"
] | 3 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF037863",
"PR01729"
] | [
"SLAP",
"SURFACELAYER"
] | [
72,
295
] | 2 | [] | [] | [] | 0 | [
"7qeh",
"7qfg",
"7qld",
"7qle",
"7qlh",
"8alu",
"8q1o"
] | 7 | [
"PUB00020346"
] | [
"8522531"
] | [
"Identification, cloning, and nucleotide sequence of a silent S-layer protein gene of Lactobacillus acidophilus ATCC 4356 which has extensive similarity with the S-layer protein gene of this species."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Lactobacillaceae"
] | [
295
] | 1 | [] | [] | 0 | true | Family | Lactobacillus surface layer protein | Lactobacillus surface layer protein | S-layer_prot | 3 |
IPR004905 | 4,905 | Tombusvirus p19 core protein | Tombusvirus_p19 | Family | 80 | false | false | This family represents the Tombusvirus P19 core protein. | [
"GO:0044423"
] | [
"virion component"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF03220"
] | [
"Tombus_P19"
] | [
80
] | 1 | [] | [] | [] | 0 | [
"1r9f",
"1rpu",
"4j39",
"4j5v",
"4jgn",
"4jk0",
"4jnx",
"4knq",
"4kq0",
"4ktg",
"6bjg",
"6bjh",
"6bjv"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Procedovirinae"
] | [
80
] | 1 | [] | [] | 0 | true | Family | Tombusvirus p19 core protein | Tombusvirus p19 core protein | Tombusvirus_p19 | 3 |
IPR004908 | 4,908 | ATPase, V1 complex, subunit H | ATPase_V1-cplx_hsu | Family | 6,285 | false | false | Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ... | [
"GO:0046961",
"GO:1902600",
"GO:0000221"
] | [
"proton-transporting ATPase activity, rotational mechanism",
"proton transmembrane transport",
"vacuolar proton-transporting V-type ATPase, V1 domain"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF03224",
"PIRSF032184",
"PTHR10698"
] | [
"V-ATPase_H_N",
"ATPase_V1_H",
""
] | [
6119,
4369,
6079
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1222556",
"R-BTA-77387",
"R-BTA-917977",
"R-BTA-9639288",
"R-BTA-983712",
"R-CEL-1222556",
"R-CEL-77387",
"R-CEL-917977",
"R-CEL-9639288",
"R-CEL-983712",
"R-DDI-1222556",
"R-DDI-77387",
"R-DDI-917977",
"R-DDI-9639288",
"R-DME-1222556",
"R-DME-77387",
"R-DME-917977",
"R-DME-... | [
"REACTOME:R-BTA-1222556",
"REACTOME:R-BTA-77387",
"REACTOME:R-BTA-917977",
"REACTOME:R-BTA-9639288",
"REACTOME:R-BTA-983712",
"REACTOME:R-CEL-1222556",
"REACTOME:R-CEL-77387",
"REACTOME:R-CEL-917977",
"REACTOME:R-CEL-9639288",
"REACTOME:R-CEL-983712",
"REACTOME:R-DDI-1222556",
"REACTOME:R-DDI-... | 41 | [
"1ho8",
"3j9t",
"3j9u",
"3j9v",
"5bw9",
"5d80",
"5vox",
"5voy",
"5voz",
"6o7v",
"6o7w",
"6o7x",
"6wm2",
"6wm3",
"6wm4",
"6xbw",
"6xby",
"7fda",
"7fdb",
"7fdc",
"7khr",
"7tmm",
"7tmo",
"7tmp",
"7tmq",
"7tmr",
"7tms",
"7tmt",
"7u4t",
"7u8o",
"7u8p",
"7u8q"... | 53 | [
"PUB00015431",
"PUB00015432",
"PUB00020603",
"PUB00020604",
"PUB00020608",
"PUB00020609",
"PUB00068786",
"PUB00068787",
"PUB00068788",
"PUB00068789"
] | [
"11416198",
"14635776",
"15473999",
"15078220",
"15907459",
"15629643",
"20450191",
"18937357",
"1385979",
"9741106"
] | [
"Crystal structure of the regulatory subunit H of the V-type ATPase of Saccharomyces cerevisiae.",
"Structure and assembly of the yeast V-ATPase.",
"The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.",
"Mechanisms of ATPases--a multi-... | [
2001,
2003,
2004,
2004,
2005,
2005,
2010,
2008,
1992,
1998
] | 10 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6285
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
2,
2,
2,
8,
6,
1,
5,
7,
1,
1,
14
] | 12 | true | Family | ATPase, V1 complex, subunit H | ATPase, V1 complex, subunit H | ATPase_V1-cplx_hsu | 1 |
IPR004909 | 4,909 | Viral heat shock protein Hsp90 homologue | Vir_Hsp90 | Family | 513 | false | false | This family includes the Beet yellows virus heat shock protein 90 homologue and other hypothetical proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03225"
] | [
"Viral_Hsp90"
] | [
513
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
513
] | 1 | [] | [] | 0 | true | Family | Viral heat shock protein Hsp90 homologue | Viral heat shock protein Hsp90 homologue | Vir_Hsp90 | 1 |
IPR004910 | 4,910 | Yippee/Mis18/Cereblon | Yippee/Mis18/Cereblon | Domain | 16,780 | false | false | This domain is found in both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins [ ]. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A [ , ]. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03226"
] | [
"Yippee-Mis18"
] | [
16780
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-606279",
"R-BTA-6798695",
"R-DME-6798695",
"R-HSA-606279",
"R-HSA-6798695",
"R-HSA-9679191",
"R-MMU-606279",
"R-MMU-6798695",
"R-RNO-606279"
] | [
"REACTOME:R-BTA-606279",
"REACTOME:R-BTA-6798695",
"REACTOME:R-DME-6798695",
"REACTOME:R-HSA-606279",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-9679191",
"REACTOME:R-MMU-606279",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-606279"
] | 9 | [
"3wx1",
"3wx2",
"4ci1",
"4ci2",
"4ci3",
"4tz4",
"4tzc",
"4tzu",
"5fqd",
"5hj0",
"5hxb",
"5j6p",
"5v3o",
"5yiz",
"5yj0",
"5yj1",
"6bn7",
"6bn8",
"6bn9",
"6bnb",
"6boy",
"6h0f",
"6h0g",
"6uml",
"6xk9",
"7bqu",
"7bqv",
"7lps",
"7sfz",
"7u8f",
"8cvp",
"8d7u"... | 86 | [
"PUB00020578",
"PUB00066712",
"PUB00078711",
"PUB00078712",
"PUB00078713",
"PUB00163258"
] | [
"11240639",
"22552327",
"25569776",
"17199038",
"22264723",
"28173693"
] | [
"The Drosophila gene Yippee reveals a novel family of putative zinc binding proteins highly conserved among eukaryotes.",
"Keeping centromeric identity.",
"The thalidomide-binding domain of cereblon defines the CULT domain family and is a new member of the β-tent fold.",
"Priming of centromere for CENP-A recr... | [
2001,
2012,
2015,
2007,
2012,
2017
] | 6 | [] | [
"IPR034750",
"IPR034751",
"IPR034752"
] | 0 | 3 | 0 | [
"Eukaryota",
"Pseudomonadati",
"metagenomes"
] | [
16774,
4,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
40,
3,
15,
6,
18,
23,
2,
18,
28,
1,
2,
27
] | 12 | true | Domain | Yippee/Mis18/Cereblon | Yippee/Mis18/Cereblon | Yippee/Mis18/Cereblon | 8 |
IPR004911 | 4,911 | Gamma interferon inducible lysosomal thiol reductase GILT | Interferon-induced_GILT | Family | 8,583 | false | false | In humans, GILT (gamma-interferon-inducible lysosomal thiol reductase) functions in MHC class II-restricted antigen processing and MHC class I-restricted cross-presentation by reducing disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation [ , ]. Several other functions of GILT... | [
"GO:0016671"
] | [
"oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF03227",
"PTHR13234"
] | [
"GILT",
""
] | [
8343,
8322
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-2132295",
"R-CEL-2132295",
"R-DRE-2132295",
"R-HSA-2132295",
"R-HSA-877300",
"R-MMU-2132295",
"R-RNO-2132295",
"R-SSC-2132295"
] | [
"REACTOME:R-BTA-2132295",
"REACTOME:R-CEL-2132295",
"REACTOME:R-DRE-2132295",
"REACTOME:R-HSA-2132295",
"REACTOME:R-HSA-877300",
"REACTOME:R-MMU-2132295",
"REACTOME:R-RNO-2132295",
"REACTOME:R-SSC-2132295"
] | 8 | [
"6nwx"
] | 1 | [
"PUB00083905",
"PUB00083906",
"PUB00083909"
] | [
"24491521",
"21506690",
"23246037"
] | [
"Identification of gamma-interferon-inducible lysosomal thiol reductase (GILT) homologues in the fruit fly Drosophila melanogaster.",
"Disulfide reduction in the endocytic pathway: immunological functions of gamma-interferon-inducible lysosomal thiol reductase.",
"Expanding roles for GILT in immunity."
] | [
2014,
2011,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria candidate phyla",
"Eukaryota"
] | [
3,
66,
8514
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
29,
8,
3,
11,
4,
1,
1,
7,
2,
12
] | 10 | true | Family | Gamma interferon inducible lysosomal thiol reductase GILT | Gamma interferon inducible lysosomal thiol reductase GILT | Interferon-induced_GILT | 7 |
IPR004912 | 4,912 | Adenoviral core protein VII | Adeno_VII | Family | 363 | false | false | Adenoviruses encode a highly basic protein called protein VII that resembles cellular histones. Protein VII forms complexes with nucleosomes, limiting DNA accessibility, and sequesters protein HMGB1 in the chromatin. HMGB1 is normally released in response to inflammatory stimuli and mediates activation of immune respon... | [
"GO:0019028"
] | [
"viral capsid"
] | [
"cellular_component"
] | 1 | [
"HAMAP",
"PFAM"
] | [
"MF_04056",
"PF03228"
] | [
"ADV_PVII",
"Adeno_VII"
] | [
250,
363
] | 2 | [] | [] | [] | 0 | [
"6yba",
"9lr9"
] | 2 | [
"PUB00019103",
"PUB00086034"
] | [
"3743550",
"27362237"
] | [
"Adenoviral protein VII packages intracellular viral DNA throughout the early phase of infection.",
"A core viral protein binds host nucleosomes to sequester immune danger signals."
] | [
1986,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Adenoviridae",
"Bacteria"
] | [
359,
4
] | 2 | [] | [] | 0 | true | Family | Adenoviral core protein VII | Adenoviral core protein VII | Adeno_VII | 3 |
IPR004913 | 4,913 | Herpesvirus glycoprotein J | Herpes_gJ | Family | 201 | false | false | The exact function of the herpesvirus glycoprotein J is unknown, but it appears to play a role in the inhibition of apotosis of the host cell [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03229"
] | [
"Alpha_GJ"
] | [
201
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00014949"
] | [
"11090178"
] | [
"Glycoprotein D or J delivered in trans blocks apoptosis in SK-N-SH cells induced by a herpes simplex virus 1 mutant lacking intact genes expressing both glycoproteins."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Simplexvirus",
"freshwater metagenome"
] | [
24,
112,
64,
1
] | 4 | [] | [] | 0 | true | Family | Herpesvirus glycoprotein J | Herpesvirus glycoprotein J | Herpes_gJ | 1 |
IPR004914 | 4,914 | Antirestriction protein | Antirestrict | Family | 3,691 | false | false | This family includes various protein that are involved in antirestriction. The ArdB protein efficiently inhibits restriction by members of the three known families of type I systems of Escherichia coli [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03230"
] | [
"Antirestrict"
] | [
3691
] | 1 | [] | [] | [] | 0 | [
"2kmg",
"2wj9"
] | 2 | [
"PUB00007215"
] | [
"8393008"
] | [
"Plasmid pKM101 encodes two nonhomologous antirestriction proteins (ArdA and ArdB) whose expression is controlled by homologous regulatory sequences."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"bioreactor metagenome",
"plasmids"
] | [
3666,
5,
7,
3,
10
] | 5 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Antirestriction protein | Antirestriction protein | Antirestrict | 1 |
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