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help me reduce LogP value and QED score of molecule CCO[C@H](CC)C(=O)N[C@H](C)CN(C)C(=O)c1ccsc1. | CCO[C@H](CC)C(=O)N[C@@H](CN(C)C(=O)c1ccsc1)C(N)=[NH2+] |
Help me reduce the number of hydrogen bond acceptors in molecule C[C@@H](C[C@@H](C)CS(=O)(=O)NN(C)C)N[C@@H](C)c1nnc2ccccn12 | CC(C)C[C@H](C)C[C@H](C)N[C@@H](C)c1nnc2ccccn12 |
Help me make the molecule COc1cc(C)cc(-c2noc([C@@H](NC(=O)c3ccccc3)C(C)C)n2)c1 with more hydrogen bond acceptors | CNCCNS(=O)(=O)[C@H](NC(=O)c1ccccc1)c1nc(-c2cc(C)cc(OC)c2)no1 |
help me reduce LogP value and QED score and improve synthetic accessibility of molecule C[C@@H](CNC(=O)NCc1ncn(C)n1)CN1CCOCC1. | CC(C[NH+](CNC(=O)NC[C@H](C)CN1CCOCC1)Cc1ncn(C)n1)C(=O)[O-] |
help me reduce hydrogen bond acceptors and rotatable bonds and synthetic accessibility of molecule CC(C[NH+](CNC(=O)c1cnn2c(-c3ccccc3Cl)ccnc12)Cc1ccc(F)cc1)C(=O)[O-]. | O=C(NCc1ccc(F)cc1)c1cnn2c(-c3ccccc3Cl)ccnc12 |
help me reduce QED score and improve rotatable bonds of molecule COc1ccc(-n2cnnn2)cc1C(=O)N1CCC(CCO)(c2ccc(C)c(C)c2)C1. | COc1ccc(-n2cnnn2)cc1C(=O)N1CCC(CCC(C)=CCCBr)(c2ccc(C)c(C)c2)C1 |
help me improve molecular weight and rotatable bonds and synthetic accessibility of molecule Cc1c(C(=O)N(C)C[C@@H]2CCN2CC2CC2)oc2c(F)cccc12. | CCC(CC)(CC)Sc1c(C(=O)N(C)C[C@@H]2CCN2CC2CC2)oc2c(F)cccc12 |
Help me reduce the number of hydrogen bond donors in molecule C[C@@H](O)CN1CC[C@@H](NC(=O)c2cn(C)c(B(O)O)cc2=O)C1 | Cc1cc(=O)c(C(=O)N[C@@H]2CCN(C[C@@H](C)O)C2)cn1C |
help me reduce molecular weight and rotatable bonds and synthetic accessibility and improve QED score of molecule CCC(CC)(CC)Sc1ccc(N2C[C@H](C(=O)NCc3ccoc3)CC2=O)cc1F. | Cc1ccc(N2C[C@H](C(=O)NCc3ccoc3)CC2=O)cc1F |
help me reduce LogP value and improve H-bond donors of molecule CC(C)(C)OC(=O)N1CCC(N(C(=O)c2ccc(-c3ccc(C(N)=O)cc3)cc2)C2CC2)CC1. | CC(C)(C)OC(=O)N1CCC(N(C(=O)c2cc(C(N)=[NH+]O)ccc2-c2ccc(C(N)=O)cc2)C2CC2)CC1 |
help me reduce GSK3β inhibitory activity and H-bond donors of molecule CNC(=O)CN1CCC[C@@H](NC(=O)c2cncnc2)[C@H]1C(N)=[NH2+]. | CNC(=O)CN1CCC[C@@H](NC(=O)c2cncnc2)[C@H]1C |
Help me reduce the number of hydrogen bond donors in molecule CCCCCC(Cc1nc(-c2cccc(O)n2)no1)C(N)=[NH2+] | CCCCC[C@@H](C)Cc1nc(-c2cccc(O)n2)no1 |
help me reduce LogP value and improve hydrogen bond acceptors and rotatable bonds of molecule C[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)NC12CCC(CC1)C2. | CC(C)C[NH+](CC(=O)[O-])C(F)(F)c1ccc(C[C@@H](C)C(=O)NC23CCC(CC2)C3)cc1 |
help me reduce QED score and improve hydrogen bond acceptors of molecule CCN(CCCF)[C@H](C)CNC(=O)c1nc2c(s1)CCC2. | CCN(CCCNC(=O)C(=O)NN)[C@H](C)CNC(=O)c1nc2c(s1)CCC2 |
help me reduce LogP value and improve hydrogen bond acceptors and rotatable bonds and synthetic accessibility of molecule Cn1c(=O)ccc2c(NC(=O)NC3CC(C)(C(F)F)Oc4ccccc43)cccc21. | CC(C)C[NH+](CC(=O)[O-])[C@@H](F)C1(C)CC(NC(=O)Nc2cccc3c2ccc(=O)n3C)c2ccccc2O1 |
help me reduce LogP value and QED score and improve hydrogen bond acceptors and molecular weight of molecule CCc1ncc(CNC(=O)NC[C@@H]2C[C@@H]2C2CCOCC2)o1. | CCc1ncc(C[NH+](CNC(=O)NC[C@@H]2C[C@@H]2C2CCOCC2)CC(C)C(=O)[O-])o1 |
help me improve GSK3β inhibitory activity and hydrogen bond acceptors and H-bond donors of molecule Cc1c(-c2ccccc2)c(C#N)c(N)c(C#N)c1N1CCC(C)CC1. | CC1CCN(c2c(C#N)c(N)c(C#N)c(-c3ccccc3)c2B(O)O)CC1 |
help me improve molecular weight and rotatable bonds of molecule CN=C(NCC(=O)Nc1ccc(F)cc1)N1CCC2(CCCC2)C1. | CC1CCC(CCN=C(NCC(=O)Nc2ccc(F)cc2)N2CCC3(CCCC3)C2)CC1 |
help me reduce hydrogen bond acceptors and synthetic accessibility of molecule CCCCC[C@H]1CCCN1C(=O)CNC(=O)NC[NH+](Cc1ccc(F)cc1)CC(C)C(=O)[O-]. | CCCCC[C@H]1CCCN1C(=O)CNC(=O)NCc1ccc(F)cc1 |
Help me reduce the QED of molecule NCC1CCC(n2cnc3cnc4c(ccn4S(=O)(=O)c4ccccc4)c32)CC1 to make it less like a drug | CC(NCC1CCC(n2cnc3cnc4c(ccn4S(=O)(=O)c4ccccc4)c32)CC1)c1ccc(Cl)cc1 |
Help me improve the QED of molecule CCOc1ccccc1OCCn1c(=O)[nH]c2sc(C(N)=[NH2+])cc2c1=O to make it more like a drug | CCOc1ccccc1OCCn1c(=O)[nH]c2sc(C)cc2c1=O |
Help me make the molecule CCC(CC)CC(C)CCC(=O)c1cc2cc(-c3ccnc(C(=O)CCc4ccncc4)c3)ccc2[nH]1 with more hydrogen bond acceptors | COCC(=O)c1cc2cc(-c3ccnc(C(=O)CCc4ccncc4)c3)ccc2[nH]1 |
help me reduce LogP value and improve rotatable bonds and synthetic accessibility of molecule COc1cc(Cl)ccc1CC(=O)N1C[C@H]2COC[C@@H](C1)[C@H]2NC(=O)C1(Br)CC1. | COc1cc(Cl)ccc1CC(=O)N1C[C@@H]2COC[C@H](C1)[C@@H]2NC(=O)C([NH3+])C1(C[NH2+]Br)CC1 |
help me reduce DRD2 binding affinity and molecular weight and synthetic accessibility and improve QED score of molecule CCCC(CCBr)COc1ccc2[nH]cc(CCN3CCN(CC)CC3=O)c2c1. | CCN1CCN(CCc2c[nH]c3ccc(OC)cc23)C(=O)C1 |
help me reduce LogP value and improve synthetic accessibility of molecule C#CC1(CCC(C)=O)COC(C)(C)O1. | C#CC1(CCC(=O)C(N)=[NH2+])COC(C)(C)O1 |
Help me reduce the number of hydrogen bond donors in molecule CCOC(=O)C(CCC(=O)O)NC(=O)C(N)Cc1ccccc1 | CCOC(=O)C(CCC(=O)O)NC(=O)C(CC(F)=C(F)F)Cc1ccccc1 |
help me reduce hydrogen bond acceptors and H-bond donors and JNK3 binding affinity of molecule O=C(CCC1CC12CCN(C(=O)c1c(B(O)O)nc3ccccn13)CC2)c1cc2ccncc2o1. | Cc1nc2ccccn2c1C(=O)N1CCC2(CC1)CC2CCC(=O)c1cc2ccncc2o1 |
help me improve hydrogen bond acceptors and H-bond donors of molecule Cc1cc(N)cc(C)c1S(=O)(=O)NCCC(C)S(C)=O. | Cc1cc(N)cc(B(O)O)c1S(=O)(=O)NCCC(C)S(C)=O |
Help me reduce the QED of molecule COc1cccc(C(=O)CN2CCN(CC(C)C)CC2)c1 to make it less like a drug | CCCCCCC(CN1CCN(CC(=O)c2cccc(OC)c2)CC1)C(C)C |
help me reduce GSK3β inhibitory activity and H-bond donors and improve LogP value of molecule CC[C@@H](CC(=O)N[C@@]1(C)CCN(c2nc(C3CCC3)ns2)C1)C(N)=[NH2+]. | CC[C@H](C)CC(=O)N[C@@]1(C)CCN(c2nc(C3CCC3)ns2)C1 |
help me improve JNK3 binding affinity and rotatable bonds of molecule COc1cc2c(c(O)c1OC)C1Cc3ccc(OC)c(OC)c3C[N+]1(C)CC2. | CCSc1ccccc1Oc1c(OC)cc2c(c1O)C1Cc3ccc(OC)c(OC)c3C[N+]1(C)CC2 |
help me improve GSK3β inhibitory activity and JNK3 binding affinity and molecular weight of molecule Cc1cccc(CNC[C@@H](O)c2cccc(OCc3ccccc3)c2)c1C. | Cc1c(CNC[C@@H](O)c2cccc(OCc3ccccc3)c2)cccc1-c1ccc(Cl)c(Cl)c1 |
Help me make the molecule CCCC(CC(F)=C(F)F)NC(=O)C1CCCN1C(=O)C1CCC(=O)N1 with more hydrogen bond acceptors | CCCC(N)NC(=O)C1CCCN1C(=O)C1CCC(=O)N1 |
Help me improve the QED of molecule CCCCCCCCC(=O)OC1CCC(CCNS(=O)(=O)c2ccc(Cl)cc2)CC1 to make it more like a drug | CC(=O)OC1CCC(CCNS(=O)(=O)c2ccc(Cl)cc2)CC1 |
help me reduce QED score and improve rotatable bonds and synthetic accessibility of molecule Cc1cc(C(=O)N(C)C2CCN(Cc3ccccc3)CC2)on1. | CCC(CC)(CC)SN(C(=O)c1cc(C)no1)C1CCN(Cc2ccccc2)CC1 |
help me reduce GSK3β inhibitory activity and molecular weight and rotatable bonds and improve QED score of molecule CCCc1ccc(-c2cccc(F)c2CCn2c(C3CC3)nnc2N2CCC[C@@H](C(C)C)C2)s1. | CC(C)[C@@H]1CCCN(c2nnc(C3CC3)n2CCc2c(F)cccc2F)C1 |
Help me reduce the QED of molecule Cc1ccc(S(=O)(=O)N2CCC(N3C(=O)c4ccccc4C3=O)C2)s1 to make it less like a drug | CCCCCCCCc1ccc(S(=O)(=O)N2CCC(N3C(=O)c4ccccc4C3=O)C2)s1 |
Help me make the molecule NC(=[NH2+])N(Cc1ccc(Sc2ccccn2)o1)[C@H]1CCNC1=O with more hydrogen bond acceptors | CN(Cc1ccc(Sc2ccccn2)o1)[C@H]1CCNC1=O |
help me reduce hydrogen bond acceptors and improve QED score of molecule CN(C)C(=O)CCOc1ccc(C(=O)O)cc1C(F)(F)NC(=O)C(=O)NN. | CN(C)C(=O)CCOc1ccc(C(=O)O)cc1C(F)(F)F |
help me reduce GSK3β inhibitory activity and JNK3 binding affinity of molecule CC(C)(C)OC(=O)N1[C@H]2C[C@H]2C[C@@H]1C(=O)N1CC2(CCCN2C(=O)c2ccc(-c3cc(Br)ccc3F)nc2)C1. | COc1ccc(C(=O)N2CCCC23CN(C(=O)[C@H]2C[C@@H]4C[C@@H]4N2C(=O)OC(C)(C)C)C3)cn1 |
help me reduce LogP value and improve H-bond donors of molecule CCCC1C(=O)NCC(C(C)(C)C)=C(C(C)(C)C)C1=O. | CCCC1C(=O)NCC(C(C)(C)C(N)=[NH2+])=C(C(C)(C)C)C1=O |
help me reduce molecular weight and improve QED score of molecule CC(Oc1cccc([C@@H]2CCCN2C(=O)c2cccc3c2OCO3)c1)c1ccc(Cl)cc1. | COc1cccc([C@@H]2CCCN2C(=O)c2cccc3c2OCO3)c1 |
Help me improve the QED of molecule CCCCC(CC)COCOc1cc(C(=O)NCCc2ccccn2)ccc1OCc1cscn1 to make it more like a drug | COc1cc(C(=O)NCCc2ccccn2)ccc1OCc1cscn1 |
help me reduce DRD2 binding affinity and GSK3β inhibitory activity of molecule [C-]#[N+]c1ncc(N2C(=O)C3(CCC3)N(c3ccc(N(C)C4CCN(C)CC4)cc3)C2=S)cc1-c1cc(C)c(Br)c(F)c1. | [C-]#[N+]c1ncc(N2C(=O)C3(CCC3)N(c3ccc(N(C)C4CCN(C)CC4)cc3)C2=S)cc1C |
help me reduce rotatable bonds and improve DRD2 binding affinity and QED score of molecule CCCCC(Sc1ccc(Cl)cc1NC1CCN(C[C@@H]2CCCO2)CC1)C(C)C. | CSc1ccc(Cl)cc1NC1CCN(C[C@@H]2CCCO2)CC1 |
help me reduce GSK3β inhibitory activity and hydrogen bond acceptors and molecular weight and rotatable bonds and improve LogP value of molecule CC(C[NH+](Cc1coc(C2CC2)n1)CN(C)[C@H]1CCN(C(=O)[C@H]2CCC(C)(C)C2)C1)C(=O)[O-]. | CN(Cc1coc(C2CC2)n1)[C@H]1CCN(C(=O)[C@H]2CCC(C)(C)C2)C1 |
Help me reduce the number of hydrogen bond acceptors in molecule Cc1sccc1C(=O)N[C@H]1C[C@H](CNCc2cccc(Cl)n2)C1 | CCCC(=CC[C@H]1C[C@H](NC(=O)c2ccsc2C)C1)Cc1cccc(Cl)n1 |
help me reduce LogP value and improve GSK3β inhibitory activity and H-bond donors of molecule CSCC(O)(c1ccc2c(cnn2-c2ccccc2)c1)C(C)(F)F. | CSCC(O)(c1ccc2c(cnn2-c2ccccc2)c1)C(C)(F)NC(=O)C(=O)NN |
help me reduce molecular weight and synthetic accessibility and improve QED score of molecule CC(C)Cc1ccc(C(=O)N[C@H]2C[C@H](NC[NH+](Cc3nccs3)CC(C)C(=O)[O-])C2)cc1. | CC(C)Cc1ccc(C(=O)N[C@H]2C[C@H](NCc3nccs3)C2)cc1 |
help me improve DRD2 binding affinity and synthetic accessibility of molecule CCCCn1c(=O)c2ccccc2n(Cc2nc(-c3ccc(Br)cc3)no2)c1=O. | CCCCCCC(Cc1nc(-c2ccc(Br)cc2)no1)n1c(=O)n(CCCC)c(=O)c2ccccc21 |
Help me reduce the number of hydrogen bond donors in molecule CC[C@H](c1ccncc1)N(C(N)=[NH2+])C(=O)N=c1nc(C)[nH]n1CC | CC[C@H](c1ccncc1)N(C)C(=O)N=c1nc(C)[nH]n1CC |
help me reduce DRD2 binding affinity and synthetic accessibility of molecule CCCC(CCBr)COc1ccccc1N1CCN(C(=O)CN2CCCC(O)C2)CC1=O. | COc1ccccc1N1CCN(C(=O)CN2CCCC(O)C2)CC1=O |
Help me reduce the QED of molecule CC1(C)CCC[C@@H]1C(=O)NC1CC2(CC(NCc3ccccn3)C2)C1 to make it less like a drug | CC1CCC(CCC2(C)CCC[C@@H]2C(=O)NC2CC3(CC(NCc4ccccn4)C3)C2)CC1 |
Help me make the molecule Cc1cc(C(=O)OCC(=O)Nc2cc(Cl)c(Cl)cc2Cl)on1 with more hydrogen bond acceptors | Cc1cc(C(=O)OCC(=O)Nc2cc(Cl)c(Sc3cc(Cl)ccc3Cl)cc2Cl)on1 |
help me improve hydrogen bond acceptors and H-bond donors of molecule Cc1nc(CNc2ccc(C(F)(F)F)cc2C(N)=S)cs1. | Cc1nc(CNc2ccc(C(F)(F)NC(=O)C(=O)NN)cc2C(N)=S)cs1 |
Help me reduce the number of hydrogen bond donors in molecule CC(C)(CO)[C@@H](CNc1nc(C(F)(F)F)cs1)c1ccccc1 | CC(C)(CCc1ccccc1)[C@@H](CNc1nc(C(F)(F)F)cs1)c1ccccc1 |
help me reduce QED score and improve molecular weight and rotatable bonds and synthetic accessibility of molecule COc1ccc(C)cc1Nc1ncc(C(=O)Nc2cccc(C)c2C)cn1. | CCC(CC)(CC)SOc1ccc(C)cc1Nc1ncc(C(=O)Nc2cccc(C)c2C)cn1 |
help me reduce LogP value and improve rotatable bonds and synthetic accessibility of molecule Cc1c(C(=O)N2C[C@@H](C)[C@H](NCC[C@@H](C)F)C2)cnc2ccccc12. | Cc1c(C(=O)N2C[C@@H](NCC[C@@H](C)[NH+](CC(=O)[O-])CC(C)C)[C@H](C)C2)cnc2ccccc12 |
help me reduce GSK3β inhibitory activity and hydrogen bond acceptors and H-bond donors and improve QED score of molecule CCc1nc(Nc2cccc(C(F)(F)NC(=O)C(=O)NN)c2)sc1C(=O)[O-]. | CCc1nc(Nc2cccc(C(F)(F)F)c2)sc1C(=O)[O-] |
help me reduce LogP value and improve molecular weight and synthetic accessibility of molecule CCC(CNC(=O)OC(C)(C)C)NCc1c[nH]c2ccccc12. | CCC(C[NH+](CNC(=O)OC(C)(C)C)CC(C)C(=O)[O-])NCc1c[nH]c2ccccc12 |
Help me reduce the QED of molecule CC1(C)CC(c2cn(-c3ccc(F)c(F)c3)cn2)CC(C)(C)O1 to make it less like a drug | CCCC(CCBr)CC1(C)C[C@@H](c2cn(-c3ccc(F)c(F)c3)cn2)CC(C)(C)O1 |
Help me make the molecule CCC(CCNC(=O)NCC1(C)Cc2ccccc2C1)C(C)(C)CC with more hydrogen bond donors | CCC(O)CCNC(=O)NCC1(C)Cc2ccccc2C1 |
Help me reduce the number of hydrogen bond donors in molecule CC(C[NH+](CO)CC1CCCCC1NC(=O)Nc1ccc2c(n1)CCCC2=O)C(=O)[O-] | O=C(Nc1ccc2c(n1)CCCC2=O)NC1CCCCC1CO |
help me reduce QED score and improve synthetic accessibility of molecule Cc1nc(CSc2ccccc2C(=O)N2CCN(Cc3ccncc3)CC2)cs1. | C=C[C@@H](CCCCCCC)c1nc(CSc2ccccc2C(=O)N2CCN(Cc3ccncc3)CC2)cs1 |
help me reduce molecular weight and improve QED score of molecule CCC(CC)(CC)S[C@@H](CNC(=S)NC[C@H]1CCCCO1)Oc1ccccc1Cl. | C[C@@H](CNC(=S)NC[C@H]1CCCCO1)Oc1ccccc1Cl |
help me reduce rotatable bonds and improve QED score of molecule Cc1cc(C(=O)N2CCC[C@@H]2CC2CCC(CCNCc3cnccc3C)CC2)cs1. | Cc1cc(C(=O)N2CCC[C@@H]2CNCc2cnccc2C)cs1 |
help me reduce LogP value and improve H-bond donors and synthetic accessibility of molecule CC(=O)Nc1cccc(C(CN=[N+]=[N-])(c2ccc(C(=N)N)cc2)C(C)C)c1. | CC(=O)Nc1cccc(C(CN=[N+]=[N-])(c2ccc(C(=N)N)cc2)[C@@H](C)C(N)=[NH2+])c1 |
Help me make the molecule Cc1cc(C(N)=O)ccc1NC(=O)N[C@H](C)C1(c2ccccc2)CCCC1 with more hydrogen bond acceptors | C[C@@H](NC(=O)Nc1ccc(C(N)=O)cc1B(O)O)C1(c2ccccc2)CCCC1 |
help me improve DRD2 binding affinity and rotatable bonds of molecule CC[C@H](c1ccc(F)cc1)N1C[C@H]2COCC[C@@]2(C(=O)NC)C1. | CCCC(CCBr)CNC(=O)[C@@]12CCOC[C@@H]1CN([C@H](CC)c1ccc(F)cc1)C2 |
help me improve hydrogen bond acceptors and LogP value and rotatable bonds and synthetic accessibility of molecule O=C(c1cc2ncccn2n1)N1CCOC[C@@]2(C1)CN(C(=O)c1cc(F)ccc1Cl)CCO2. | CC(C)C(C)SSC(C)(C)c1ccc(F)cc1C(=O)N1CCO[C@@]2(COCCN(C(=O)c3cc4ncccn4n3)C2)C1 |
help me reduce H-bond donors and synthetic accessibility of molecule CN1CC(=NN)N(Cc2ccc(C(N)=[NH2+])cc2)C1=O. | Cc1ccc(CN2C(=O)N(C)CC2=NN)cc1 |
help me reduce GSK3β inhibitory activity and improve rotatable bonds and synthetic accessibility of molecule COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC1CCN(C(=O)N2CCCCC2)CC1. | CCC(CC)CC(C)Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC1CCN(C(=O)N2CCCCC2)CC1 |
help me reduce QED score and improve molecular weight and rotatable bonds of molecule CO[C@@H](c1ccc(F)cc1)c1noc([C@@H]2C[C@H]2c2ccsc2)n1. | CCSc1ccccc1O[C@@H](c1ccc(F)cc1)c1noc([C@@H]2C[C@H]2c2ccsc2)n1 |
help me reduce LogP value and improve hydrogen bond acceptors and H-bond donors and synthetic accessibility of molecule Cc1cc(NC(=O)COc2ccccc2C#N)no1. | N#Cc1ccccc1OCC(=O)Nc1cc(B(O)O)on1 |
help me improve hydrogen bond acceptors and rotatable bonds of molecule O=C(NCC1CN(c2ccc(N3CCCC3=O)cc2)C(=O)O1)c1ccc(Cl)s1. | CC(C[NH+](CNC(=O)c1ccc(Cl)s1)CC1CN(c2ccc(N3CCCC3=O)cc2)C(=O)O1)C(=O)[O-] |
help me improve GSK3β inhibitory activity and JNK3 binding affinity of molecule COc1ccc(OC)c(NC(=O)CSc2nnc3c(C)cc4ccc(C)c(C)c4n23)c1. | COc1ccc(-c2ccc(F)c(Br)c2)c(NC(=O)CSc2nnc3c(C)cc4ccc(C)c(C)c4n23)c1 |
help me reduce QED score and improve H-bond donors of molecule CC(=O)ON1C(C)(C)CC(OCC(O)CCO)CC1(C)C. | CC(=O)ON1C(C)(C)CC(OCC(O)CCO)CC1(C)C(N)=[NH2+] |
help me reduce LogP value and improve synthetic accessibility of molecule CN(C(=O)[C@H]1CC[C@H](C(F)(F)F)C1)C1CN(Cc2ccccc2)C1. | CC(C[NH+](Cc1ccccc1)CN1CC(N(C)C(=O)[C@H]2CC[C@H](C(F)(F)F)C2)C1)C(=O)[O-] |
Help me reduce the number of hydrogen bond donors in molecule COC[C@@H](NC(=O)OC(C)(C)C)C(=O)NC[C@@]12CCCO[C@@H]1CCN(C(=O)[C@H](C)n1cccn1)C2 | C=CCC(COC)CC(CC[C@@]12CCCO[C@@H]1CCN(C(=O)[C@H](C)n1cccn1)C2)NC(=O)OC(C)(C)C |
help me improve hydrogen bond acceptors and H-bond donors of molecule CCn1cc(C(=O)NC[C@@H]2CCCN(CCC(C)C)C2)cn1. | CCn1cc(C(=O)NC[C@@H]2CCCN(CC(O)C(=O)O)C2)cn1 |
help me reduce synthetic accessibility and improve LogP value and QED score of molecule CC[C@@H](CC(C)C(N)=[NH2+])C(=O)NC[C@H](C)NC(=O)c1cccc(C)c1F. | CC[C@@H](CC(C)C)C(=O)NC[C@H](C)NC(=O)c1cccc(C)c1F |
Help me reduce the number of hydrogen bond acceptors in molecule COc1ccc(Cl)cc1NC(=O)Cn1c(=O)n(Cc2ccco2)c(=O)c2sccc21 | CCC(CC)CC(CC)c1ccc(Cl)cc1NC(=O)Cn1c(=O)n(Cc2ccco2)c(=O)c2sccc21 |
Help me reduce the number of hydrogen bond donors in molecule Cn1nccc1C1=CC2CCC(C1)N2C(=O)c1ccc(O)c(F)c1F | Cn1nccc1C1=CC2CCC(C1)N2C(=O)c1ccc(-c2ccc(Br)cc2)c(F)c1F |
Help me reduce the number of hydrogen bond donors in molecule CCCCCCC(Nc1ccc2[nH]nc(NC(=O)c3ccc(N4CCN(CCC)CC4)cc3NC3CCOCC3)c2c1)c1cc(F)cc(F)c1 | CCCN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(S(=O)(=O)c5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1 |
help me reduce QED score and improve DRD2 binding affinity and molecular weight of molecule CC[C@H](Cc1ccccc1C)C(=O)Nc1cccc(CCN2CCCC2)c1. | CC[C@H](Cc1ccccc1-c1ccc(Cl)cc1Cl)C(=O)Nc1cccc(CCN2CCCC2)c1 |
help me improve hydrogen bond acceptors and rotatable bonds and synthetic accessibility of molecule O=C(NCc1ccc(F)cc1C(F)(F)F)[C@@H]1[C@@H]2Cc3ccccc3[C@@H]21. | CC(C)C[NH+](CC(=O)[O-])C(F)(F)c1cc(F)ccc1CNC(=O)[C@H]1[C@H]2c3ccccc3C[C@H]21 |
help me improve molecular weight and synthetic accessibility of molecule Cc1ncoc1C(=O)N[C@H](C)CN(C)[C@H](C)c1cc(F)ccc1F. | CCC(CC)(CC)SC(CN(C)[C@H](C)c1cc(F)ccc1F)NC(=O)c1ocnc1C |
help me reduce hydrogen bond acceptors and molecular weight and synthetic accessibility and improve LogP value of molecule CC(C[NH+](Cc1c(F)cccc1F)C[S@@](=O)[C@@H](C)C(=O)NCC1CCCCC1)C(=O)[O-]. | C[C@@H](C(=O)NCC1CCCCC1)[S@](=O)Cc1c(F)cccc1F |
help me reduce H-bond donors and synthetic accessibility and improve LogP value of molecule COc1nc(C(N)=[NH2+])cc(=O)n1CCCC(C)C. | COc1nc(C)cc(=O)n1CCCC(C)C |
Help me make the molecule CCC(C)(C)C1CCc2c(sc(NC(=O)C3CC=CCC3C(=O)[O-])c2C(N)=O)C1 with more hydrogen bond acceptors | CC(O)(CO)C(CO)C1CCc2c(sc(NC(=O)C3CC=CCC3C(=O)[O-])c2C(N)=O)C1 |
Help me reduce the QED of molecule CC(C)COCCNC(=O)Cc1nc(CCl)cs1 to make it less like a drug | C[C@@H](COCCNC(=O)Cc1nc(CCl)cs1)C(N)=[NH2+] |
help me reduce H-bond donors and improve LogP value of molecule CC[C@@H](CNC(=O)C(N)=[NH2+])NCc1ccn(CCc2ccccc2)n1. | CC[C@@H](CNC(C)=O)NCc1ccn(CCc2ccccc2)n1 |
help me reduce hydrogen bond acceptors and improve LogP value of molecule CC(C[NH+](CNC(=O)C1(c2ccc(Cl)c(Cl)c2)CCC1)Cc1n[nH]c(=S)n1C)C(=O)[O-]. | Cn1c(CNC(=O)C2(c3ccc(Cl)c(Cl)c3)CCC2)n[nH]c1=S |
Help me reduce the number of hydrogen bond donors in molecule CS(=O)(=O)Cc1noc(-c2cc(N)ccc2B(O)O)n1 | Cc1ccc(N)cc1-c1nc(CS(C)(=O)=O)no1 |
help me reduce hydrogen bond acceptors and H-bond donors and rotatable bonds of molecule CC(=O)NC(C(=O)O)C(O)C(=O)Oc1cc(=O)c2nc(-c3cc(Cl)c4ncccc4c3)c(-c3ccccc3)nc2[nH]1. | CC(C)(C)C(=O)Oc1cc(=O)c2nc(-c3cc(Cl)c4ncccc4c3)c(-c3ccccc3)nc2[nH]1 |
Help me reduce the number of hydrogen bond acceptors in molecule CC(=O)c1sc(-c2cc(C(=O)NCC3CNC(C)CN3)nc(-c3ccc(F)nc3C)c2)c(NC2=NCCN2)c1C | Cc1nc(F)ccc1-c1cc(CNC2=NCCN2)cc(C(=O)NCC2CNC(C)CN2)n1 |
help me improve GSK3β inhibitory activity and JNK3 binding affinity and LogP value of molecule COC(=O)Nc1cccc(Cn2c([C@H]3CCC(=O)N3)nnc2N2CCC[C@@H](NC(C)=O)C2)c1. | C#Cc1ccccc1C(C)=C[C@@H]1CCCN(c2nnc([C@H]3CCC(=O)N3)n2Cc2cccc(NC(=O)OC)c2)C1 |
help me improve molecular weight and synthetic accessibility of molecule CC(C)(C(=O)N[C@@H]1CCN(C(=O)CC2CC2)C1)c1ccc(Cl)cc1. | CC(C[NH+](CC(=O)N1CC[C@@H](NC(=O)C(C)(C)c2ccc(Cl)cc2)C1)CC1CC1)C(=O)[O-] |
Help me reduce the QED of molecule COc1cc(CN[C@H]2CCCNC2)ccc1OCc1cccs1 to make it less like a drug | CC(Oc1cc(CN[C@H]2CCCNC2)ccc1OCc1cccs1)c1ccc(Cl)cc1 |
Help me reduce the number of hydrogen bond acceptors in molecule CC(C)(C)OC(=O)[C@@H](C(=O)OCCc1cnc(B(O)O)cn1)C1CCCC1 | Cc1cnc(CCOC(=O)[C@H](C(=O)OC(C)(C)C)C2CCCC2)cn1 |
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