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" pathogenic axin2 variants cause absence of permanent teeth hypodontia sparse hair and eyebrows ectodermal dysplasia and gastrointestinal polyps and cancer inheritance is autosomal dominant withvariable penetrance only twenty five patients have been reported from five families a mayo clinic pilot programtested newly... | Colon_Cancer |
section all disclosure information for gie editors can befound online at httpwwwgie contentconï¬ictoï¬nterest cme editors and their disclosures are as followsprasad g iyer md associate editor for cmeconsultingadvisoryspeaking olympus research supporttakeda pharmaamit rastogi md associate editor for cmeconsulting... | Colon_Cancer |
" accurate detection of patients with minimal residual disease mrd after surgery for stage ii coloncancer cc remains an urgent unmet clinical need to improve selection of patients who might benefit formadjuvant chemotherapy act presence of circulating tumor dna ctdna is indicative for mrd and has highpredictive value ... | Colon_Cancer |
collagen triple helix repeat containing1 cthrc1 anextracellular matrix ecm protein was identiï¬ed in thescreening of diï¬erentially expressed sequences between balloon injury and normal arteries the evolution of cthrc1can be traced back to at least million years ago and theconserved genes were not found in invertebra... | Colon_Cancer |
" colorectal cancer crc is the third leading cause of cancerassociated mortality the present study aimed to investigate novel biomarkers to predict prognosis and provide a theoretical basis for studies of the pathogenesis and the development of therapies for crc the present study compared mrna expression levels of pat... | Colon_Cancer |
coronaviruses covs belong to a family of envelopedviruses with a positive sense singlestranded rna genomecovs cause illness ranging from upper respiratory tractinfections urtis resembling the common cold to lowerrespiratory tract infections lrtis such as bronchitis pneumonia and even severe acute respiratory syndrome s... | Colon_Cancer |
" the diagnostic gold standard of hirschsprungs disease hd is based on the histopathological assessmentof colorectal biopsies although data on cholinergic innervation and ganglion cell gc distribution exist only few studieshave examined these two key features together we assessed the pattern of cholinergic innervatio... | Colon_Cancer |
in the uk the death toll from severe covid19 is among the highest worldwide1 severe covid19 is characterised by respiratory failure with socalled cytokine storm occurring in some patient subsets2 pathological correlates are required to understand the pathophysiology of covid19 autopsybased histopathologic... | Colon_Cancer |
" the activation of the nfκb pathway plays a crucial role in the progression of breast cancer bca andalso involved in endocrine therapy resistance on the contrary to the canonical nfκb pathway the effect of thenoncanonical nfκb pathway in bca progression remains elusivemethods bca tumor tissues and the correspondin... | Colon_Cancer |
"peroxisome proliferatoractivated receptorsppars asligandactivated transcription factors belong to the steroidreceptor superfamily which includes three isoforms pparalpha ppar betadelta and ppar gamma ppars formheterodimers with retinoic x receptors and regulate theexpression of various genes upon ligand binding ppar... | Colon_Cancer |
" patients with pelvic malignancies often receive radiosensitising chemotherapy with radiotherapy toimprove survival however this is at the expense of increased normal tissue toxicity particularly in elderly patientshere we explore if an alternative lowcost and nontoxic approach can achieve radiosensitisation in mice ... | Colon_Cancer |
" exercise has been extensively utilised as an effective therapy for overweight and obesityassociatedchanges that are linked to health complications several preclinical rodent studies have shown that treadmillexercise alongside an unhealthy diet improves metabolic health and microbiome composition furthermorechronic e... | Colon_Cancer |
subcutaneous hydration and medicationsinfusions effectiveness safety acceptability asystematic review of systematic reviews one e0237572 101371 pone0237572editor jose´ das neves university of portoportugalreceived november accepted july published august copyright broadhurst this is an openaccess distributed un... | Colon_Cancer |
" child maltreatment leads to enormous adverse short and longterm health outcomes the aim ofthis study is to estimate the burden of disease and the cost of illness attributable to child maltreatment in japanmethods an incidencebased topdown cost of illness analysis was conducted to estimate medical costs andburden of ... | Colon_Cancer |
gastroenteropancreatic neuroendocrine neoplasms gep nens as well as neuroendocrine tumors gep nets are heterogeneous tumors that originate from peptidergic neurons and neuroendocrine cells previously described as carcinoid tumors in most nets are indolent tumors compared with other epithelial malignancies h... | Colon_Cancer |
low levels of physical activity pa and high levels of physical inactivity pi are associatedwith higher mortality and cardiovascular diseases higher age is associated with a decreaseof pa only yearolds achieve the pa times recommended by who theaim of this study was to identify levels of and determinants for moderate p... | Colon_Cancer |
liver cancer the predominant primary malignancy ranks as the fifth most commonly diagnosed cancer in male and the seventh in female around the world in the year it has been estimated thatliver cancer is the fourth leading cause of cancer death with approximated new cases were diagnosed and over patients succumbed ... | Colon_Cancer |
" tumor associated macrophages tam constitute the most abundant immune cells in the tumor stroma initiating pro inflammatory m1 or immunosuppressive m2 responses depending on their polarization status advances in tumor immunotherapy call for a detailed understanding of potential immunogenic mechanisms of irradiation ... | Colon_Cancer |
the ongoing pandemic coronavirus disease outbreak covid2019 stemming from the beta coronavirus class sarscov2 causing severe acute respiratory syndrome sars has created a global health emergency in countries around the globe huang nalla sarscov2 a novel coronavirus strain belonging to the sarbecovirus subgenus ... | Colon_Cancer |
purpose to explore a new therapeutic option for patients with hepatocellular carcinoma hcc the efficacy and safety of a group of traditional chinese medicines banxia xiexin recipe as monotherapy for patients with advanced hcc was studied materials and methods the study included patients with advanced hcc ... | Colon_Cancer |
"dysregulation of bcl2 is a pathophysiology observed in haematological malignancies forimplementation of available treatmentoptions it is preferred to know the relative quantificationof bcl2 mrna with appropriate reference genes for the choice of reference genesi reference genes were selected by assessing variation of... | Colon_Cancer |
"although the clinical development of immune checkpoint inhibitors icis therapy has ushered in a new era of antitumor therapy with sustained responses and significant survival advantages observed in multiple tumors mostpatients do not benefit therefore more and more attention has been paid to the identification and dev... | Colon_Cancer |
primary colorectal cancer pcrc is a common digestive tract cancer in the elderly the primary lesioncan be seen in the left colon the right colon the upper or lower rectum pcrc is the second mostcommonly diagnosed cancer in women and the third most commonly diagnosed cancer in men and theprevalence of male is higher t... | Colon_Cancer |
ovarian cancer is a silent and largely asymptomatic cancer leading to late diagnosis and worseprognosis the latestage detection and low survival rates makes the study of the spacetime evolution of ovariancancer particularly relevant in addition research of this cancer in small areas like provinces or counties is stil... | Colon_Cancer |
objective cannabinoids are able to reduce tumor growth in xenograft models but their therapeutic potential as anticancer drugs in humans is unclear yet in vitro studies of the effect of cannabinoids on cancer cells are often carried out in absence of serum or in low serum concentration ie serum conditions that lim... | Colon_Cancer |
" mutations in the wilms tumor gene cause a spectrum of podocytopathy ranging from diffusemesangial sclerosis to focal segmental glomerulosclerosis in a considerable fraction of patients with wilms tumor mutations the distinctive histology of immunecomplextype glomerulonephritis has been reported however theclinical ... | Colon_Cancer |
liver cancer the predominant primary malignancy ranks as the fifth most commonly diagnosed cancer in male and the seventh in female around the world in the year it has been estimated thatliver cancer is the fourth leading cause of cancer death with approximated new cases were diagnosed and over patients succumbed ... | Colon_Cancer |
" the cell proliferative markers are very important in breast cancer since spag5 and numa proteinsplay a significant role in the mitosis regulatory network and cell division we aimed to study their mrna levels aswell as spag5 gene amplification correlated to clinicopathological status in ductal carcinoma of the breast... | Colon_Cancer |
acute myeloid leukemia aml is the most common type ofacute leukemia in adults caused by the clonal expansion ofundiï¬erentiated myeloid progenitor cells although mostpatients with aml can achieve complete remission by inductionchemotherapy the recurrence rate remains high and thus is themain factor aï¬ecting the outco... | Colon_Cancer |
" preproof 0c highlights f0b7 propolis made by bees from bioactive plant resins has antiviral activity f0b7 propolis potentially can interfere with host cell invasion by sarscov2 f0b7 propolis blocks proinflammatory pak1 a kinase highly expressed in covid19 patients propolis a resinous material produced by ... | Colon_Cancer |
recently extensive evidence has clarified the crucial role of circular rnas circrnas as a protumor or anticancer participant in human malignancies a new circrna derived from oxysterol binding protein like osbpl10 circosbpl10 has not been researched in cervical cancer cc yetmethods the expression of molecules was ... | Colon_Cancer |
" mucinous colon cancers mcc are characterized by abundant production of mucin muc2 proteinand are less sensitive to standard systemic chemotherapy we postulated that severepersistent endoplasmicreticulum stress ers aggravation in mcc would overwhelm compensatory cytoprotective pathways and induceapoptosisresults bas... | Colon_Cancer |
" drug resistance leads to tumor relapse and further progression during chemotherapy in lung cancer close homolog of l1 chl1 has been identified as a tumor suppressor in most malignancies however to the best of our knowledge whether chl1 mediates chemoresistance remains unknown the present study observed that chl... | Colon_Cancer |
to machine learning with python a guide for data scientists oreilly media inc california demšar j statistical comparisons of classifiers over multiple data sets j mach learn res yates a the ensembl rest api ensembl data for any language bioinformatics kim e r chang d k colorectal cancer in inflamma... | Colon_Cancer |
"pd1pdl1 blockade therapy is a promising cancer treatment strategy which has revolutionized the treatmentlandscape of malignancies over the last decade pd1pdl1 blockade therapy has been trialed in a broad range ofmalignancies and achieved clinical success despite the potentially curelike survival benefit only a minorit... | Colon_Cancer |
" according to the who most chronic diseases including cancer can be prevented by identifyingtheir risk factors such as unhealthy diet smoking and physical inactivity this research examined the effectiveness ofa theorybased educational intervention on colorectal cancerrelated preventive nutritional behaviors among asa... | Colon_Cancer |
" tumor associated macrophages tam constitute the most abundant immune cells in the tumor stroma initiating pro inflammatory m1 or immunosuppressive m2 responses depending on their polarization status advances in tumor immunotherapy call for a detailed understanding of potential immunogenic mechanisms of irradiation ... | Colon_Cancer |
thyroid carcinoma is presently the malignancy with the most rapidly increasing incidence in the worldand is the most widely recognized endocrine carcinoma in the western world thyroid cancers derivedfrom follicular thyroid cells can be sorted into papillary thyroid carcinoma ptc follicular thyroid carcinoma ftc and a... | Colon_Cancer |
the hypoxic tumour is a chaotic landscape of struggle and adaption against the adversity of oxygen starvationhypoxic cancer cells initiate a reprogramming of transcriptional activities allowing for survival metastasis andtreatment failure this makes hypoxia a crucial feature of aggressive tumours its importance to canc... | Colon_Cancer |
" preproof 0c highlights f0b7 propolis made by bees from bioactive plant resins has antiviral activity f0b7 propolis potentially can interfere with host cell invasion by sarscov2 f0b7 propolis blocks proinflammatory pak1 a kinase highly expressed in covid19 patients propolis a resinous material produced by ... | Colon_Cancer |
objectives paired box protein8 pax8 immunohistochemical expression can be used as a diagnostic marker for epithelial cells tumors this study aimed at investigating the immunohistochemical expression of pax8 among sudanese females diagnosed with cervical endometrial and ovarian cancers between december and may by st... | Colon_Cancer |
the molecular heterogeneity of renal cell carcinoma rcc complicates the therapeutic interventions for advancedmetastatic disease and thus its management remains a significant challenge this study investigates the role of thelncrna cdkn2bas1 and mir1413p interactions in the progression and metastasis of kidney cancer hu... | Colon_Cancer |
" the incidence of thyroid carcinoma is increasing all over the world some studies have suggestedthat the change of adipokines expression can induce thyroid carcinoma however other studies have come to theopposite therefore we studied the relationship between adipokines and thyroid carcinomamethods databasespubmed c... | Colon_Cancer |
the hypoxic tumour is a chaotic landscape of struggle and adaption against the adversity of oxygen starvationhypoxic cancer cells initiate a reprogramming of transcriptional activities allowing for survival metastasis andtreatment failure this makes hypoxia a crucial feature of aggressive tumours its importance to canc... | Colon_Cancer |
the diagnostic platform utilizing the detection of biomarkers in various body ï¬uids called liquidbiopsy can revolutionize precision medicine precision medicine is aimed at attaining betterpersonalized care by the development of the latest diagnostic and prognostic methods thatconsider individual variability kaur ... | Colon_Cancer |
" mucinous colon cancers mcc are characterized by abundant production of mucin muc2 proteinand are less sensitive to standard systemic chemotherapy we postulated that severepersistent endoplasmicreticulum stress ers aggravation in mcc would overwhelm compensatory cytoprotective pathways and induceapoptosisresults bas... | Colon_Cancer |
"piglet diarrhea is one of the most severe diseases aï¬ictingpiglets leading to their delayed growth and developmentlow feed returns and even death which has seriously damaged the economic development of pig industries globally recently clostridium perfringens the important pathogenic microanism that causes diarrhea ... | Colon_Cancer |
we report the case of a 24yearold man who presented with chief complaintsof shortness of breath and haemoptysis chest radiography revealed completecollapse of the left lung bronchoscopy revealed an endobronchial tumourwith complete obstruction of the left main bronchus cryosurgical excisionwas performed tissue patholog... | Colon_Cancer |
cancer is a complex and heterogeneous disease with many possible genetic and environmentalcauses the same treatment for patients of the same cancer type often results in different outcomes in terms ofefficacy and side effects of the treatment thus the molecular characterization of individual cancer patients isincreas... | Colon_Cancer |
sarscov2 has resulted in numerous cases of coronavirus disease covid19 worldwide in addition to feverand respiratory symptoms digestive symptoms also are observed in some patients with covid19 angiotensinconverting enzyme ace2 was reported to be the receptor for sarscov2 the aim of this study was tocomprehensively in... | Colon_Cancer |
" when we encounter patients who present with both a neck mass and nephrotic syndrome bothmalignancy and kimuras disease need to be evaluated as the therapeutic strategies differ vastly between themcase presentation we present the case of a 27yearold male patient with neck mass and nephrotic syndromethe presence of b... | Colon_Cancer |
among synchronous colorectal cancers scrcs reported previously the incidence of quadruple advanced scrcs is very rarewe present the case who underwent laparoscopic twosegment resection of the colon requiring two anastomoses that wasperformed for quadruple advanced cancers and four tumors were curatively removed there w... | Colon_Cancer |
objective cannabinoids are able to reduce tumor growth in xenograft models but their therapeutic potential as anticancer drugs in humans is unclear yet in vitro studies of the effect of cannabinoids on cancer cells are often carried out in absence of serum or in low serum concentration ie serum conditions that lim... | Colon_Cancer |
posterior reversible encephalopathy syndrome pres is a clinical syndrome that can include headache altered consciousnessvisual disturbances and seizures usually related to autoregulatory cerebral failure and hypertension the neuroimaging isessential to diagnosis showing white matter vasogenic edema in posterior areas w... | Colon_Cancer |
" the empirical dietary index for hyperinsulinemia edih score is a validated foodbased dietary scorethat assesses the ability of wholefood diets to predict plasma cpeptide concentrations although the edih hasbeen extensively applied and found to be predictive of risk of developing major chronic diseases its influence ... | Colon_Cancer |
ammation is an established risk factor for colorectal cancer we and others have shown that colorectal cancerpatients with elevated cysteinyl leukotriene receptor cyslt2r and 15hydroxyprostaglandin dehydrogenase15pgdh levels exhibit good prognoses however both cyslt2r and 15pgdh which act as tumour suppressorsare ofte... | Colon_Cancer |
" breast cancer bc is the most commonly diagnosed malignant cancer in women bc is the main cause of cancerrelated death in women and seriously threatens the life and health of women worldwide micrornas mirnasmirs have been reported to regulate the development and progression of different types of cancer however the reg... | Colon_Cancer |
nasopharyngeal carcinoma npc is an epithelial malignancy with high morbidity rates in the east and southeast asia the molecular mechanisms of npc remain largely unknown we explored the pathogenesis potential biomarkers and prognostic indicators of npcmethods we analyzed mrnas long noncoding rnas lncrnas and micror... | Colon_Cancer |
objectives paired box protein8 pax8 immunohistochemical expression can be used as a diagnostic marker for epithelial cells tumors this study aimed at investigating the immunohistochemical expression of pax8 among sudanese females diagnosed with cervical endometrial and ovarian cancers between december and may by st... | Colon_Cancer |
despite great advances in recent decades in screening diagnosisand curative surgery hepatocellular carcinoma hcc remainsthe second leading cause of cancerrelated mortality worldwidegrandhi siegel epidemiologicalevidence has conï¬rmed that the longterm outcomes of patientswith hcc have notimproved significantly w... | Colon_Cancer |
" mucinous colon cancers mcc are characterized by abundant production of mucin muc2 proteinand are less sensitive to standard systemic chemotherapy we postulated that severepersistent endoplasmicreticulum stress ers aggravation in mcc would overwhelm compensatory cytoprotective pathways and induceapoptosisresults bas... | Colon_Cancer |
" colorectal cancer crc is the third leading cause of cancerassociated mortality the present study aimed to investigate novel biomarkers to predict prognosis and provide a theoretical basis for studies of the pathogenesis and the development of therapies for crc the present study compared mrna expression levels of pat... | Colon_Cancer |
" deregulated circular rnas circrnas are associated with the development of cancer and therapyresistance however functional research of circrnas mostly focus on potential mirna or protein binding and morepotential regulation of circrna on host gene dna in cancers are yet to be inspectedmethod we performed total rna se... | Colon_Cancer |
" lung carcinoma is a prominent cause of mortality among patients with cancer previous studies have reported the vital role of long noncoding rnas lncrnas in the malignant progression of lung cancer lncrna rp11284f219 was originally identified to be expressed in lung carcinoma but its specific function remains unknown ... | Colon_Cancer |
" the widely recognized anticancer potential of aspirin has created a broad interest to explore theclinical benefits of aspirin in cancer therapy however the current understanding of the molecular mechanismsinvolved in the anticancer potential of aspirin remains limitedmethods cancer stemness assays which contained al... | Colon_Cancer |
" inflammatory pseudotumour has been used to describe an inflammatory or fibrosing tumoral processof an undetermined cause that may involve a variety of an systems including the lungs spleen liver lymphnodes pancreas and extrahepatic bile duct with potential for recurrence and persistent local growth in this we report... | Colon_Cancer |
the diagnostic platform utilizing the detection of biomarkers in various body ï¬uids called liquidbiopsy can revolutionize precision medicine precision medicine is aimed at attaining betterpersonalized care by the development of the latest diagnostic and prognostic methods thatconsider individual variability kaur ... | Colon_Cancer |
" the incidence of thyroid carcinoma is increasing all over the world some studies have suggestedthat the change of adipokines expression can induce thyroid carcinoma however other studies have come to theopposite therefore we studied the relationship between adipokines and thyroid carcinomamethods databasespubmed c... | Colon_Cancer |
" chemotherapy is one of the most commonly used treatments for patients with advanced colon cancer yet the toxicity of chemotherapy agents such as fluorouracil 5fu limits the effectiveness of chemotherapy ginsenoside rg3 rg3 is an active ingredient isolated from ginseng rg3 has been shown to display anticancer effects... | Colon_Cancer |
" excessive perioperative fluid administration may result in iatrogenic endothelial dysfunction andtissue edema transducing inflammatory markers into the bloodstream colloids remain longer in the circulationrequiring less volume to reach similar hemodynamic endpoints compared to crystalloids thus we tested thehypothes... | Colon_Cancer |
" atopic dermatitis ad is a worldwide chronic skin disease which burden public health sea buckthornsbt hippophae rhamnoides l elaeagnaceae oil as a traditional herbal medicine has been used for diseasetreatment for many years the effects of sbt oil on ad mouse model induced by repeated administration of dinitrochlorob... | Colon_Cancer |
" adenovirus serotype ad5 is a commonly used viral vector for transient delivery of transgenes primarily for vaccination against pathogen and tumor antigens however endemic infections with ad5 produce virus specific neutralizing antibodies nabs that limit transgene delivery and constrain target directed immunity fol... | Colon_Cancer |
advances in technology hardware and computing have created new opportunities to improve the quality of cancer care and research by leveraging informatics innovations digital health machine learning and precision oncology are key areas where there are noteworthy advances in the field of cancer informatics ... | Colon_Cancer |
" inflammatory pseudotumour has been used to describe an inflammatory or fibrosing tumoral processof an undetermined cause that may involve a variety of an systems including the lungs spleen liver lymphnodes pancreas and extrahepatic bile duct with potential for recurrence and persistent local growth in this we report... | Colon_Cancer |
the ongoing pandemic coronavirus disease outbreak covid2019 stemming from the beta coronavirus class sarscov2 causing severe acute respiratory syndrome sars has created a global health emergency in countries around the globe huang nalla sarscov2 a novel coronavirus strain belonging to the sarbecovirus subgenus ... | Colon_Cancer |
" african americans aa are at high risk for colorectal cancer crc studies report a increasein crc risk with physical inactivity obesity and metabolic syndrome activation of the wntcatenin ctnnb1signaling pathway plays a critical role in colorectal carcinogenesis accumulating evidence also indicates a role ofwntctnnb... | Colon_Cancer |
ammatory bowel disease ibd is a chronic immunemediated disease mainly consisting of two diseases crohnsdisease cd and ulcerative colitis uc cd is active in anypart of the gastrointestinal tract from the mouth to the anuswhile uc is restricted to the colonic mucosa e etiologyand pathology of ibd remain largely unk... | Colon_Cancer |
" excessive perioperative fluid administration may result in iatrogenic endothelial dysfunction andtissue edema transducing inflammatory markers into the bloodstream colloids remain longer in the circulationrequiring less volume to reach similar hemodynamic endpoints compared to crystalloids thus we tested thehypothes... | Colon_Cancer |
" preproof 0c highlights f0b7 propolis made by bees from bioactive plant resins has antiviral activity f0b7 propolis potentially can interfere with host cell invasion by sarscov2 f0b7 propolis blocks proinflammatory pak1 a kinase highly expressed in covid19 patients propolis a resinous material produced by ... | Colon_Cancer |
"eph receptors and the corresponding eph receptorinteracting ephrin ligands jointly constitute a critical cellsignaling network that has multiple functions the tyrosine kinase epha2 which belongs to the family of ephreceptors is highly produced in tumor tissues while found at relatively low levels in most normal adult ... | Colon_Cancer |
recently extensive evidence has clarified the crucial role of circular rnas circrnas as a protumor or anticancer participant in human malignancies a new circrna derived from oxysterol binding protein like osbpl10 circosbpl10 has not been researched in cervical cancer cc yetmethods the expression of molecules was ... | Colon_Cancer |
"it is well understood that the level of molecular oxygen o2 in tissue is a very important factor impacting both physiology and pathological processes as well as responsiveness to some treatments data on o2 in tissue could be effectively utilized to enhance precision medicine however the nature of the data that can be ... | Colon_Cancer |
laparoscopic surgery for rectal cancer is commonly performed in china however compared with open surgerythe effectiveness of laparoscopic surgery especially the longterm survival has not been sufï¬ciently provedmethods data of eligible patients with nonmetastatic rectal cancer at nanfang hospital of southern medical... | Colon_Cancer |
"the kinetics and localization of the reactions of metabolism are coordinated by the enzymes that catalyze themthese enzymes are controlled via a myriad of mechanisms including inhibitionactivation by metabolitescompartmentalization thermodynamics and nutrient sensingbased transcriptional or posttranslational regulatio... | Colon_Cancer |
low levels of physical activity pa and high levels of physical inactivity pi are associatedwith higher mortality and cardiovascular diseases higher age is associated with a decreaseof pa only yearolds achieve the pa times recommended by who theaim of this study was to identify levels of and determinants for moderate p... | Colon_Cancer |
moringa oleifera l from the moringaceae family is a perennial tree widely cultivated in many tropic regions and easily grown even in adverse conditions m oleifera is also known as the miracle tree which for centuries has been indicated for traditional medicine with no reports of side effects in doses achievable by inge... | Colon_Cancer |
"ammatory bowel disease ibd is a long life disease with remission and relapse periods ibd arises as a result of inappropriateimmune response to intestinal commensal anisms in individualswith genetic predisposition and consequently causes ammation andintestinal ulcers in addition ibd has a complex pathogenesis andma... | Colon_Cancer |
acute myeloid leukemia aml is the most common type ofacute leukemia in adults caused by the clonal expansion ofundiï¬erentiated myeloid progenitor cells although mostpatients with aml can achieve complete remission by inductionchemotherapy the recurrence rate remains high and thus is themain factor aï¬ecting the outco... | Colon_Cancer |
" accurate detection of patients with minimal residual disease mrd after surgery for stage ii coloncancer cc remains an urgent unmet clinical need to improve selection of patients who might benefit formadjuvant chemotherapy act presence of circulating tumor dna ctdna is indicative for mrd and has highpredictive value ... | Colon_Cancer |
" inflammatory pseudotumour has been used to describe an inflammatory or fibrosing tumoral processof an undetermined cause that may involve a variety of an systems including the lungs spleen liver lymphnodes pancreas and extrahepatic bile duct with potential for recurrence and persistent local growth in this we report... | Colon_Cancer |
" mucinous colon cancers mcc are characterized by abundant production of mucin muc2 proteinand are less sensitive to standard systemic chemotherapy we postulated that severepersistent endoplasmicreticulum stress ers aggravation in mcc would overwhelm compensatory cytoprotective pathways and induceapoptosisresults bas... | Colon_Cancer |
objective this study aimed to test the hypothesis that levobupivacaine has antitumour effects on breast cancer cellsresults colony formation and transwell assay were used to determine breast cancer cells proliferation flow cytometry annexin v and pi staining was used to investigate breast cancer cells apoptosis th... | Colon_Cancer |
"gut microbiota composition influences the balance between human health and disease increasing evidencesuggests the involvement of microbial factors in regulating cancer development progression and therapeuticresponse distinct microbial species have been implicated in modulating gut environment and architecture thataff... | Colon_Cancer |
"carcinogenesis is a process of somatic evolution previous models of stem and transient amplifying cells in epithelial proliferating units like colonic crypts showed that intermediate numbers of stem cells in a crypt should optimally prevent progression to cancer if a stem cell population is too small it is easy for a ... | Colon_Cancer |
"it is well understood that the level of molecular oxygen o2 in tissue is a very important factor impacting both physiology and pathological processes as well as responsiveness to some treatments data on o2 in tissue could be effectively utilized to enhance precision medicine however the nature of the data that can be ... | Colon_Cancer |
purpose pancreatic ductal adenocarcinomas exhibit a high degree of desmoplasia due to extensive extracellular matrix deposition encasement of mesenteric vessels by stroma in locally advanced pancreatic cancer lapc prevents surgical resection this study sought to determine if the addition of a monoclonal antibody to co... | Colon_Cancer |
" mutations in the wilms tumor gene cause a spectrum of podocytopathy ranging from diffusemesangial sclerosis to focal segmental glomerulosclerosis in a considerable fraction of patients with wilms tumor mutations the distinctive histology of immunecomplextype glomerulonephritis has been reported however theclinical ... | Colon_Cancer |
" adenovirus serotype ad5 is a commonly used viral vector for transient delivery of transgenes primarily for vaccination against pathogen and tumor antigens however endemic infections with ad5 produce virus specific neutralizing antibodies nabs that limit transgene delivery and constrain target directed immunity fol... | Colon_Cancer |
purpose pancreatic ductal adenocarcinomas exhibit a high degree of desmoplasia due to extensive extracellular matrix deposition encasement of mesenteric vessels by stroma in locally advanced pancreatic cancer lapc prevents surgical resection this study sought to determine if the addition of a monoclonal antibody to co... | Colon_Cancer |
chrysoperla nipponensis okamoto which has the unique diapause phenotype distinguishable from nondiapause adult is an ideal model anism for studying the mechanism of reproductive diapause however there is no reliable and effective reference genes used for the reproductive diapause study of c a0nipponensi... | Colon_Cancer |
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