Mardiyyah/TAPT_data_V2_split · Datasets at Hugging Face

PMCID stringclasses 24 values	Title stringclasses 24 values	Sentences stringlengths 2 40.7k
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	patient tissues were obtained under a protocol approved by Stanford University’s Human Subjects Research Compliance Office (IRB 15166).
PMC10287567	An integrated cell atlas of the lung in health and disease.	Informed consent was obtained from each patient before surgery.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	healthy control lungs were obtained under a protocol approved by the University of Pittsburgh Committee for Oversight of Research and Clinical Training Involving Decedents (CORID protocol 718) and following rejection as candidate donors for transplant (IRB STUDY 19100326).
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	tissue samples were obtained from the Cambridge Biorepository for Translational Medicine (CBTM) with approval from the National Research Ethics Services (NRES) Committee of East of England—Cambridge South (15/EE/0152).
PMC10287567	An integrated cell atlas of the lung in health and disease.	Tissue samples were obtained with informed consent from the donor families.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	the protocol was approved by the Northwestern University IRB (STU00212120).
PMC10287567	An integrated cell atlas of the lung in health and disease.	Written informed consent was obtained from all individuals in the study.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For the pooled data from ref.
PMC10287567	An integrated cell atlas of the lung in health and disease.	and associated unpublished data, the protocol was approved by the IRB (Algemeen Beoordelings- en Registratieformulier number NL69765.042.19).
PMC10287567	An integrated cell atlas of the lung in health and disease.	Patients gave informed consent.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	the National Jewish Health IRB approved the research under IRB protocols HS-3209 and HS-2240.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Informed consent was obtained from authorized family members of all donors.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	approval was given by the NRES Committee of East of England—Cambridge South (Research Ethics Committee (REC) reference: 15/EE/0152).
PMC10287567	An integrated cell atlas of the lung in health and disease.	Informed consent for use of the tissue was obtained from the donors’ families.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For Barbry_unpubl (P.B., L.-E.Z., M.J.A., A.C., C.B. et al., newly generated dataset), the protocol was approved by the Centre Hospitalier Universitaire de Nice.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Nasal and tracheobronchial samples were collected from patients with IPF after obtaining their informed consent.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	approved was given by the IRB of Northwestern University (STU00212120, STU00213177, STU00212511 and STU00212579).
PMC10287567	An integrated cell atlas of the lung in health and disease.	For inclusion in this study, patients or their designated medical power of attorney provided informed consent.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For Duong_lungMAP_unpubl (T.E.D., K.Z., X.S., J.S.H. and G.P., newly generated dataset), all postmortem human donor lung samples were obtained from the Biorepository for Investigation of Neonatal Diseases of the Lung (BRINDL), supported by the National Heart, Lung, and Blood Institute (NHLBI) LungMAP Human Tissue Core housed at the University of Rochester.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Consent can be found on the repository’s website (brindl.urmc.rochester.edu/).
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	the study was conducted in accordance with the Declaration of Helsinki and Department of Health and Human Services Belmont Report.
PMC10287567	An integrated cell atlas of the lung in health and disease.	The use of biomaterial and data for this study was approved by the local ethics committee of the Medical Faculty Heidelberg (S-270/2001 and S-538/2012).
PMC10287567	An integrated cell atlas of the lung in health and disease.	All individuals gave informed consent for inclusion before they participated in the study.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	human lung tissues were procured under each institution’s approved IRB protocol (numbers 00035396 (Cedars-Sinai Medical Center), 03-1396 (University of North Carolina at Chapel Hill), 1172286 (Cystic Fibrosis Foundation and WIRB-Copernicus Group Western IRB) and 16-000742 (University of California, Los Angeles)).
PMC10287567	An integrated cell atlas of the lung in health and disease.	Informed consent was obtained from lung donors or their authorized representatives.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	the study was approved and monitored by the National Jewish Health IRB (FWA00000778).
PMC10287567	An integrated cell atlas of the lung in health and disease.	Written informed consent was obtained from all participants.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	the study protocol was approved by the Partners Healthcare IRB (protocol 2011P002419).
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	lung tissue was obtained under a protocol approved by the University of Pittsburgh IRB (IRB STUDY 19100326) during transplantation surgery.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	the study was conducted according to the principles expressed in the Declaration of Helsinki.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Ethical approval was obtained from Ethics Committee Research UZ/KU Leuven (S63881).
PMC10287567	An integrated cell atlas of the lung in health and disease.	All participants provided written informed consent for sample collection and subsequent analyses.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	approval was given by the NRES Committee of East of England—Cambridge South (15/EE/0152).
PMC10287567	An integrated cell atlas of the lung in health and disease.	The CBTM operates in accordance with UK Human Tissue Authority guidelines.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Samples were obtained from deceased transplant organ donors by the CBTM with informed consent from the donor families.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	ethical approval was given through the Living Airway Biobank, administered through the University College London Great Ormond Street Institute of Child Health (REC reference: 19/NW/0171; Integrated Research Application System (IRAS) project ID: 261511; North West Liverpool East REC), REC reference 18/SC/0514 (IRAS project ID: 245471; South Central Hampshire B REC; administered through the University College London Hospitals NHS Foundation Trust), REC reference 18/EE/0150 (IRAS project ID: 236570; East of England—Cambridge Central REC; administered through Great Ormond Street Hospital NHS Foundation Trust) and REC reference 08/H0308/267 (administered through the Cambridge University Hospitals NHS Foundation Trust), as well as by the local R&D departments at all hospitals.
PMC10287567	An integrated cell atlas of the lung in health and disease.	All of the study participants or their surrogates provided informed consent.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	all protocols were reviewed and approved by the IRB at the Memorial Sloan Kettering Cancer Center (IRB protocol 14-091).
PMC10287567	An integrated cell atlas of the lung in health and disease.	Noninvolved lung, tumor tissues and metastatic lesions were obtained from patients with lung adenocarcinoma undergoing resection surgery at the Memorial Sloan Kettering Cancer Center after obtaining informed consent.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	samples underwent IRB review and approval at the institutions where they were originally collected.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Specifically, the Dana-Farber Cancer Institute approved protocol 13-416, the partners Massachusetts General Hospital and Brigham and Women’s Hospital approved protocols 2020P000804, 2020P000849 and 2015P002215, the Beth Israel Deaconess Medical Center approved protocols 2020P000406 and 2020P000418 and New York Presbyterian Hospital/Columbia University Irving Medical Center approved protocols IRB-AAAT0785, IRB-AAAB2667 and IRB-AAAS7370.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Secondary analysis of samples at the Broad Institute was covered under Massachusetts Institute of Technology IRB protocols 1603505962 and 1612793224, or the Not Human Subjects Research protocol ORSP-3635.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Donor identities were encoded at the hospitals before shipping to or sharing with the Broad Institute for sample processing or data analysis, respectively.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	the study was approved by the local ethics committee of the Ludwig Maximilian University of Munich (EK 333-10 and 382-10).
PMC10287567	An integrated cell atlas of the lung in health and disease.	Written informed consent was obtained from all patients.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For Schiller_2021 (H.B.S., J.G.-S., C.H.M., B.H.K., M.A. et al., newly generated dataset), the study was approved by the local ethics committee of the Ludwig Maximilian University of Munich (EK 333-10 and 382-10).
PMC10287567	An integrated cell atlas of the lung in health and disease.	Written informed consent was obtained from all patients.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For Schultze_unpubl (J.L.S., C.S.F., T.S.K. and E.C., newly generated dataset), human lung tissue was available for research purposes following ethical approval from Hannover Medical School (ethical vote of the German Centre for Lung Research (DZL) number 7414, 2017).
PMC10287567	An integrated cell atlas of the lung in health and disease.	All patients in this study provided written informed consent for sample collection and data analysis.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	samples were obtained under the Cells and Mediators IRB protocol (2003P002088).
PMC10287567	An integrated cell atlas of the lung in health and disease.	All individuals provided written informed consent.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	the studies described were conducted according to the principles of the Declaration of Helsinki.
PMC10287567	An integrated cell atlas of the lung in health and disease.	The study was approved by the University of California, San Francisco IRB.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Written informed consent was obtained from all individuals.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	peripheral blood was obtained from healthy consenting adult volunteers by venipuncture through a protocol approved by the Columbia University IRB.
PMC10287567	An integrated cell atlas of the lung in health and disease.	All relevant ethical regulations for work with human participants were complied with.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	donor lung samples were provided through the federal United Network for Organ Sharing via the National Disease Research Interchange and International Institute for the Advancement of Medicine and entered into the NHLBI LungMAP BRINDL at the University of Rochester Medical Center, overseen by the IRB as RSRB00047606.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For for the pooled data from ref.
PMC10287567	An integrated cell atlas of the lung in health and disease.	and associated unpublished data, human lung tissue collection was approved by the Duke University IRB (Pro00082379) and University of North Carolina Biomedical IRB (03-1396) under exempt protocols.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Consent was obtained to use human tissues for research purposes.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	the study was approved by the local ethics committee at University Hospitals Leuven (B322201422081) and all of the relevant ethical regulations were complied with.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Only patients with untreated, primary, nonmetastatic lung tumors who underwent lung lobe resection with curative intent and who provided informed consent were included in this study.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	all of the research involving human participants was approved by the Northwestern University IRB.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Samples from patients with COVID-19, viral pneumonia and other pneumonia, as well as controls without pneumonia, were collected from participants enrolled in the Successful Clinical Response in Pneumonia Therapy study STU00204868.
PMC10287567	An integrated cell atlas of the lung in health and disease.	All study participants or their surrogates provided informed consent.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	the IRB of the University of Cincinnati College of Medicine approved all human-relevant studies.
PMC10287567	An integrated cell atlas of the lung in health and disease.	For ref. ,
PMC10287567	An integrated cell atlas of the lung in health and disease.	the study was conducted according to the principles expressed in the Declaration of Helsinki.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Ethical approval was obtained from the REC of Shenzhen Third People’s Hospital (2020-112).
PMC10287567	An integrated cell atlas of the lung in health and disease.	All participants provided written informed consent for sample collection and subsequent analyses.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Further study details can be found in Supplementary Table 1.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Several previously unpublished datasets were used for the HLCA and generated as follows.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Participants recruited by the Pneumology Unit of Nice University Hospital were sampled between 1 and 15 December 2020.
PMC10287567	An integrated cell atlas of the lung in health and disease.	The full procedure, including patient inclusion criteria, is detailed at https://www.clinicaltrials.gov/ct2/show/NCT04529993.
PMC10287567	An integrated cell atlas of the lung in health and disease.	Nasal and tracheobronchial samples were collected from patients with IPF after obtaining their informed consent, following a protocol approved by the Centre Hospitalier Universitaire de Nice.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

patient tissues were obtained under a protocol approved by Stanford University’s Human Subjects Research Compliance Office (IRB 15166).

PMC10287567

An integrated cell atlas of the lung in health and disease.

Informed consent was obtained from each patient before surgery.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

healthy control lungs were obtained under a protocol approved by the University of Pittsburgh Committee for Oversight of Research and Clinical Training Involving Decedents (CORID protocol 718) and following rejection as candidate donors for transplant (IRB STUDY 19100326).

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

tissue samples were obtained from the Cambridge Biorepository for Translational Medicine (CBTM) with approval from the National Research Ethics Services (NRES) Committee of East of England—Cambridge South (15/EE/0152).

PMC10287567

An integrated cell atlas of the lung in health and disease.

Tissue samples were obtained with informed consent from the donor families.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

the protocol was approved by the Northwestern University IRB (STU00212120).

PMC10287567

An integrated cell atlas of the lung in health and disease.

Written informed consent was obtained from all individuals in the study.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For the pooled data from ref.

PMC10287567

An integrated cell atlas of the lung in health and disease.

and associated unpublished data, the protocol was approved by the IRB (Algemeen Beoordelings- en Registratieformulier number NL69765.042.19).

PMC10287567

An integrated cell atlas of the lung in health and disease.

Patients gave informed consent.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

the National Jewish Health IRB approved the research under IRB protocols HS-3209 and HS-2240.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Informed consent was obtained from authorized family members of all donors.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

approval was given by the NRES Committee of East of England—Cambridge South (Research Ethics Committee (REC) reference: 15/EE/0152).

PMC10287567

An integrated cell atlas of the lung in health and disease.

Informed consent for use of the tissue was obtained from the donors’ families.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For Barbry_unpubl (P.B., L.-E.Z., M.J.A., A.C., C.B. et al., newly generated dataset), the protocol was approved by the Centre Hospitalier Universitaire de Nice.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Nasal and tracheobronchial samples were collected from patients with IPF after obtaining their informed consent.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

approved was given by the IRB of Northwestern University (STU00212120, STU00213177, STU00212511 and STU00212579).

PMC10287567

An integrated cell atlas of the lung in health and disease.

For inclusion in this study, patients or their designated medical power of attorney provided informed consent.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For Duong_lungMAP_unpubl (T.E.D., K.Z., X.S., J.S.H. and G.P., newly generated dataset), all postmortem human donor lung samples were obtained from the Biorepository for Investigation of Neonatal Diseases of the Lung (BRINDL), supported by the National Heart, Lung, and Blood Institute (NHLBI) LungMAP Human Tissue Core housed at the University of Rochester.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Consent can be found on the repository’s website (brindl.urmc.rochester.edu/).

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

the study was conducted in accordance with the Declaration of Helsinki and Department of Health and Human Services Belmont Report.

PMC10287567

An integrated cell atlas of the lung in health and disease.

The use of biomaterial and data for this study was approved by the local ethics committee of the Medical Faculty Heidelberg (S-270/2001 and S-538/2012).

PMC10287567

An integrated cell atlas of the lung in health and disease.

All individuals gave informed consent for inclusion before they participated in the study.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

human lung tissues were procured under each institution’s approved IRB protocol (numbers 00035396 (Cedars-Sinai Medical Center), 03-1396 (University of North Carolina at Chapel Hill), 1172286 (Cystic Fibrosis Foundation and WIRB-Copernicus Group Western IRB) and 16-000742 (University of California, Los Angeles)).

PMC10287567

An integrated cell atlas of the lung in health and disease.

Informed consent was obtained from lung donors or their authorized representatives.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

the study was approved and monitored by the National Jewish Health IRB (FWA00000778).

PMC10287567

An integrated cell atlas of the lung in health and disease.

Written informed consent was obtained from all participants.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

the study protocol was approved by the Partners Healthcare IRB (protocol 2011P002419).

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

lung tissue was obtained under a protocol approved by the University of Pittsburgh IRB (IRB STUDY 19100326) during transplantation surgery.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

the study was conducted according to the principles expressed in the Declaration of Helsinki.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Ethical approval was obtained from Ethics Committee Research UZ/KU Leuven (S63881).

PMC10287567

An integrated cell atlas of the lung in health and disease.

All participants provided written informed consent for sample collection and subsequent analyses.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

approval was given by the NRES Committee of East of England—Cambridge South (15/EE/0152).

PMC10287567

An integrated cell atlas of the lung in health and disease.

The CBTM operates in accordance with UK Human Tissue Authority guidelines.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Samples were obtained from deceased transplant organ donors by the CBTM with informed consent from the donor families.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

ethical approval was given through the Living Airway Biobank, administered through the University College London Great Ormond Street Institute of Child Health (REC reference: 19/NW/0171; Integrated Research Application System (IRAS) project ID: 261511; North West Liverpool East REC), REC reference 18/SC/0514 (IRAS project ID: 245471; South Central Hampshire B REC; administered through the University College London Hospitals NHS Foundation Trust), REC reference 18/EE/0150 (IRAS project ID: 236570; East of England—Cambridge Central REC; administered through Great Ormond Street Hospital NHS Foundation Trust) and REC reference 08/H0308/267 (administered through the Cambridge University Hospitals NHS Foundation Trust), as well as by the local R&D departments at all hospitals.

PMC10287567

An integrated cell atlas of the lung in health and disease.

All of the study participants or their surrogates provided informed consent.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

all protocols were reviewed and approved by the IRB at the Memorial Sloan Kettering Cancer Center (IRB protocol 14-091).

PMC10287567

An integrated cell atlas of the lung in health and disease.

Noninvolved lung, tumor tissues and metastatic lesions were obtained from patients with lung adenocarcinoma undergoing resection surgery at the Memorial Sloan Kettering Cancer Center after obtaining informed consent.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

samples underwent IRB review and approval at the institutions where they were originally collected.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Specifically, the Dana-Farber Cancer Institute approved protocol 13-416, the partners Massachusetts General Hospital and Brigham and Women’s Hospital approved protocols 2020P000804, 2020P000849 and 2015P002215, the Beth Israel Deaconess Medical Center approved protocols 2020P000406 and 2020P000418 and New York Presbyterian Hospital/Columbia University Irving Medical Center approved protocols IRB-AAAT0785, IRB-AAAB2667 and IRB-AAAS7370.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Secondary analysis of samples at the Broad Institute was covered under Massachusetts Institute of Technology IRB protocols 1603505962 and 1612793224, or the Not Human Subjects Research protocol ORSP-3635.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Donor identities were encoded at the hospitals before shipping to or sharing with the Broad Institute for sample processing or data analysis, respectively.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

the study was approved by the local ethics committee of the Ludwig Maximilian University of Munich (EK 333-10 and 382-10).

PMC10287567

An integrated cell atlas of the lung in health and disease.

Written informed consent was obtained from all patients.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For Schiller_2021 (H.B.S., J.G.-S., C.H.M., B.H.K., M.A. et al., newly generated dataset), the study was approved by the local ethics committee of the Ludwig Maximilian University of Munich (EK 333-10 and 382-10).

PMC10287567

An integrated cell atlas of the lung in health and disease.

Written informed consent was obtained from all patients.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For Schultze_unpubl (J.L.S., C.S.F., T.S.K. and E.C., newly generated dataset), human lung tissue was available for research purposes following ethical approval from Hannover Medical School (ethical vote of the German Centre for Lung Research (DZL) number 7414, 2017).

PMC10287567

An integrated cell atlas of the lung in health and disease.

All patients in this study provided written informed consent for sample collection and data analysis.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

samples were obtained under the Cells and Mediators IRB protocol (2003P002088).

PMC10287567

An integrated cell atlas of the lung in health and disease.

All individuals provided written informed consent.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

the studies described were conducted according to the principles of the Declaration of Helsinki.

PMC10287567

An integrated cell atlas of the lung in health and disease.

The study was approved by the University of California, San Francisco IRB.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Written informed consent was obtained from all individuals.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

peripheral blood was obtained from healthy consenting adult volunteers by venipuncture through a protocol approved by the Columbia University IRB.

PMC10287567

An integrated cell atlas of the lung in health and disease.

All relevant ethical regulations for work with human participants were complied with.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

donor lung samples were provided through the federal United Network for Organ Sharing via the National Disease Research Interchange and International Institute for the Advancement of Medicine and entered into the NHLBI LungMAP BRINDL at the University of Rochester Medical Center, overseen by the IRB as RSRB00047606.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For for the pooled data from ref.

PMC10287567

An integrated cell atlas of the lung in health and disease.

and associated unpublished data, human lung tissue collection was approved by the Duke University IRB (Pro00082379) and University of North Carolina Biomedical IRB (03-1396) under exempt protocols.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Consent was obtained to use human tissues for research purposes.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

the study was approved by the local ethics committee at University Hospitals Leuven (B322201422081) and all of the relevant ethical regulations were complied with.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Only patients with untreated, primary, nonmetastatic lung tumors who underwent lung lobe resection with curative intent and who provided informed consent were included in this study.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

all of the research involving human participants was approved by the Northwestern University IRB.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Samples from patients with COVID-19, viral pneumonia and other pneumonia, as well as controls without pneumonia, were collected from participants enrolled in the Successful Clinical Response in Pneumonia Therapy study STU00204868.

PMC10287567

An integrated cell atlas of the lung in health and disease.

All study participants or their surrogates provided informed consent.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

the IRB of the University of Cincinnati College of Medicine approved all human-relevant studies.

PMC10287567

An integrated cell atlas of the lung in health and disease.

For ref. ,

PMC10287567

An integrated cell atlas of the lung in health and disease.

the study was conducted according to the principles expressed in the Declaration of Helsinki.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Ethical approval was obtained from the REC of Shenzhen Third People’s Hospital (2020-112).

PMC10287567

An integrated cell atlas of the lung in health and disease.

All participants provided written informed consent for sample collection and subsequent analyses.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Further study details can be found in Supplementary Table 1.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Several previously unpublished datasets were used for the HLCA and generated as follows.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Participants recruited by the Pneumology Unit of Nice University Hospital were sampled between 1 and 15 December 2020.

PMC10287567

An integrated cell atlas of the lung in health and disease.

The full procedure, including patient inclusion criteria, is detailed at https://www.clinicaltrials.gov/ct2/show/NCT04529993.

PMC10287567

An integrated cell atlas of the lung in health and disease.

Nasal and tracheobronchial samples were collected from patients with IPF after obtaining their informed consent, following a protocol approved by the Centre Hospitalier Universitaire de Nice.