id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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2,309 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Confirmation of diagnosis of dystrophinopathy, documented by clinical exam and
dystrophin DNA mutation analysis
- Ambulatory male subjects between the ages of 7-11 years
- Stable dosage of corticosteroids for 3 months prior to entry (Screening/Basel... | Safety, Tolerability and Effects of L-Arginine in Boys With Dystrophinopathy on Corticosteroids | NCT01388764 | Entailment |
5,692 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Turner syndrome by karyotype
Exclusion Criteria:
- Thyroid abnormality
- Glucocorticoid treatment
Female
Accepts Healthy Volunteers
| Quantitative Liver Functions in Turner Syndrome With and Without Hormone Replacement Therapy | NCT00825617 | Entailment |
1,006 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Chronic (lasting a long time) primary osteoarthritis knee pain, one or two side with
stage II Kellgen-Lawrence, for more than 3 months with Visual Analogue Scale (VAS)
more than 4
- Good knee deformity, no limit range of motion
- Partic... | Efficacy and Safety Study of Transdermal Therapeutic System (TTS) Fentanyl in Participants With Osteoarthritis Knee Pain | NCT01742897 | Entailment |
6,581 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Diagnosis of congenital haemophilia A or B with inhibitors development against FVIII
or FIX, respectively
Exclusion Criteria:
- Prophylactic administration of any haemostatic drug within 3 last months prior to
entering the trial.
Male
No h... | Efficacy of NovoSeven® in Bleeding Prophylaxis in Hemophilia | NCT00108758 | Contradiction |
2,711 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Clinical diagnosis of a primary unilateral inguinal hernia
Exclusion Criteria:
- Medically unfit for surgical repair
Male
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
| Isolation of the Spermatic Cord in Mesh Inguinal Hernia Repair | NCT01391455 | Entailment |
1,985 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Aged 18-75 years；
2. Primary lesion is diagnosed with endometrial biopsy as adenocarcinoma of the stomach
or esophagogastric junction, including: papillary adenocarcinoma, tubular
adenocarcinoma, mucinous adenocarcinoma, poorly cohesive carcinoma (i... | The Safety of Totally Laparoscopic Versus Laparoscopy-Assisted Total Gastrectomy. | NCT04351321 | Entailment |
5,802 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Patients presenting with a clinical picture that assumes the diagnosis of erosive oral
lichen planus (bilateral, more or less symmetrical erosive lesions with lacelike
network of slightly raised gray white lesions (reticular pattern), and a histological
... | Efficacy of Intralesional Injection of Platelet Rich Plasma in the Treatment of Patients With Erosive Oral Lichen Planus | NCT03293368 | Entailment |
5,789 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Age 18 or older, both genders
- History of recurrent aphthous ulcers with 4 or more episodes per year
Exclusion Criteria:
- History of salivary gland disease including Sjogren's disease, parotitis, and
sialolithiasis
- History o... | Salivary Catecholamines in Aphthous Stomatitis (Canker Sores) | NCT00556686 | Contradiction |
5,859 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Subjects who seek medical advice in primary care for symptoms thought to be GERD
related (GERD is a condition which develops when the reflux of stomach content causes
troublesome symptoms and / or complications).
Exclusion Criteria:
- Subj... | Nexium (Esomeprazole) in Symptom Adapted Therapy in GERD Patients | NCT00444275 | Contradiction |
2,283 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Completion of ataluren treatment in the previous Phase 2a study (Protocol
PTC124-GD-004-DMD).
- Ability to provide written informed consent (parental/guardian consent if
applicable)/assent (if <18 years of age).
- Confirmed screening la... | Phase 2a Extension Study of Ataluren (PTC124) in Duchenne Muscular Dystrophy (DMD) | NCT00759876 | Contradiction |
1,432 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Subjects must be scheduled for non-urgent appointment at primary care practice
including annual wellness visits and routine follow-up appointments.
- Subjects must be over the age of 18
- Subjects must be able to give informed consent
- ... | Pilot Study for Imaging of the Esophagus Using a Tethered Capsule OCT Endomicroscopy in the Primary Care Setting | NCT02445027 | Contradiction |
161 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Males between 18-75 years of age
- Two fasting serum testosterone levels <300 ng/dL
Exclusion Criteria:
- Previous use of the study drug
- History of prostate or breast cancer
- Prostate-Specific Antigen (PSA) ≥3 ng/mL
... | A Clinical Trial to Evaluate the Efficacy and Safety of Testosterone Gel in Adult Hypogonadal Males | NCT02149264 | Entailment |
6,365 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Signed informed consent, demonstrating that the subject understands the procedures
required for the study and the purpose of the study
2. Healthy, ambulant male or female subjects 18 years of age to 65 years of age
3. Positive test for COVID-19 by RT-... | A Study of Combination Therapies to Treat COVID-19 Infection | NCT04459702 | Entailment |
833 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Patients had to have a documented diagnosis of osteoarthritis of their knees.
- Patients had to be between 50 and 70 years inclusive.
- Patients had to have X-ray evidence of osteoarthritis of their knees.
Exclusion Criteria:
- Patients with... | An Examination of the Value of Shortwave Diathermy and Hydrotherapy for Patients With Osteoarthritis of Their Knees | NCT00726492 | Entailment |
5,084 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Female
- 65 years or older
- Diagnosed with osteoporosis (Bone Mineral Density (BMD) T-score <= -2.5 at spine or
hip) or prior fragility fracture BMD T-score <=-1.5 in at least one of the anatomic
sites including lumbar spine, total hip... | A Study to Test the Effect of MK0217A on Vitamin D Inadequacy in Postmenopausal Women With Osteoporosis (0217A-262) | NCT00692913 | Contradiction |
6,423 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | --> INCLUSION CRITERIA
CRITERIA RELATED TO THE POPULATION:
- Male or female subject having signed a written informed consent for his/her
participation to the study
- Subject with a phototype II to IV according to the Fitzpatrick scale
- Subject affiliated to a s... | Use of the SpiderMass for in Vivo Analysis of the Skin in Five Chronic Inflammatory Dermatosis | NCT04472546 | Entailment |
6,432 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Between the ages of 18-70
- No systemic illness
- No other inflammatory dermatoses except for rosacea
- No smoking
- Not using any topical, systemic treatment and sunblock at least a month for rosacea or
other condition
... | Demodex Density, Immune Response and Oxidative Stress in Rosacea Patients | NCT02556827 | Entailment |
3,214 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Has provided written informed consent;
- Between the ages of 18-75 years (inclusive);
- Body weight ≥ 40 kg;
- Meets the revised European criteria proposed by the American-European Consensus Group
for primary Sjögren's Syndrome at screen... | Baminercept, a Lymphotoxin-Beta Receptor Fusion Protein, for Treatment of Sjögren's Syndrome | NCT01552681 | Entailment |
728 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- 1. Male or female ≥ 50 years old; 2. Symptomatic OA of one or both knees, according to
ACR criteria, diagnosed at least 6 months previously; 3. Pain in either knee
originates in the knee (not referred pain from other sites, such as hip or back) and
... | Efficacy and Safety of Diclofenac DDEA 2.32 % in Patient Suffering From Knee Osteoarthritis (OA) | NCT01967550 | Contradiction |
5,526 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
1. Diagnostic criteria for Giant Cell Arteritis Age at disease onset >50 years (required)
1. New onset or new type of localized pain in the head
2. Temporal artery abnormality (i.e. temporal artery tenderness to palpation or decreased
pulsation, unrelated ... | One-Time DNA Study for Vasculitis | NCT01241305 | Entailment |
4,541 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- BMI < 35
- Premenopausal
- Uterine size <20 gw
- Willingness to participate to the research
- Uterine fibroids with typical symptoms
- Maximum of 4 treated fibroids
- Dominant fibroid >2.5cm
- >50% of t... | Treatment of Benign Uterine Disorders Using High Intensity Focused Ultrasound (MR-HIFU) | NCT02914704 | Contradiction |
5,013 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Existing unilateral or bilateral VIN DBS for ET, non-demented (MMSE>24), and must have
a documented suboptimal tremor suppression on two successive visits (compared to the
baseline post-operative improvement at 6 months following ET DBS surgery). For
... | Physiology, Imaging and Modeling of Essential Tremor | NCT03811405 | Entailment |
1,464 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion criteria: - patients with diagnosed dysphagia "of any causes"
- sufficient proficiency in german
- voluntary participation
Exclusion criteria: - insufficient knowledge of the german language
- cognitive limitations
- reduced general state of health
No c... | Translation of the Sydney Swallow Questionnaire and Validation of the German Version | NCT01965964 | Entailment |
3,667 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
- Able to demonstrate the necessary abilities (English language, literacy) needed to
provide informed consent without the assistance of another person (e.g., a proxy,
spouse, family member or other support person)
- Self-reported low back pain (acute... | measurINg forceS durInG cHiropractic Treatment | NCT02409797 | Contradiction |
5,989 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- diagnosis of typical GERD
- partial responder to a stable standard clinical symptoms control dose of PPI therapy
- body mass index ≤ 32 kg/m2
Exclusion Criteria:
- exclusively atypical symptoms of GERD
- symptoms that have been s... | ADX10059 as an add-on Therapy to Proton Pump Inhibitors (PPIs) in Patients With Gastroesophageal Reflux (GERD) | NCT00810485 | Entailment |
4,496 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Age 19-40 years
- Mean menstrual cycle 28-38 days
- Good general health
- Generally normal sleep-wake regimen
- Motivated for free participation
Exclusion Criteria:
- Low cooperation
- Medications known to... | Effect of Bright Light on Sex Hormones and Ovulation in Humans | NCT00327366 | Contradiction |
1,703 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Participants include young and healthy women between the ages of 18-30, who have not
engaged in strength training for the last 6 months.
Exclusion Criteria:
- Subjects will be excluded from the study if they have any condition that preclude them
... | High Intensity Strength Training & Bone Mineral Density in Young Women | NCT01482130 | Entailment |
5,076 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
1. Has the subject given informed consent according to local requirements before any
trial-related activities? A trial-related activity is any procedure that would not
have been performed during the routine management of the subject.
2. Is the subject ... | STEP: Study of Imaging Techniques (ImaTx and DXA) in Postmenopausal Women With OstEoporosis Using Preotact (FP-008-ES) | NCT00583518 | Contradiction |
3,618 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- All patients age 18+ presenting with epistaxis that requires an ENT consult that had a
first attempt at treatment by an emergency physician.
Exclusion Criteria:
- Patients will be excluded based on the presence of a hypo-coagulable state. Including
... | Management of Persistent Epistaxis Using Floseal Hemostatic Matrix | NCT02488135 | Entailment |
1,030 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Female - 50 years of age or older
- Knee pain on most days of the week
- Less than 30 minutes of morning stiffness
- Bony enlargement
- Bony tenderness to palpation
- Signs of inflammation
- Able to safely climb 2 ... | Yoga as an Intervention for Women With Knee Osteoarthritis | NCT02146105 | Entailment |
6,328 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Laboratory confirmed SARS-CoV-2 using currently available laboratory testing
techniques (e.g.,RT-PCR, Immunoglobulin M (IgM) /IgG) or clinical history compatible
with a COVID-19 like illness(fever, cough, shortness of breath).
- Negative participan... | Determinants of SARS-COV2 (COVID-19) Persistence After Convalescence | NCT04448145 | Entailment |
6,520 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Severe hemophilia A with FVIII activity < 1% normal
- Weight > 3.5 kg at the time of baseline study evaluation
- Informed consent, approved by appropriate Institutional Review Board/Independent
Ethics Committee, has been administered, signed, and da... | Hemophilia Inhibitor Previously Untreated Patient Study | NCT01652027 | Contradiction |
342 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Having ≤ 2 IVF/ICSI cycles
- Total sperm count and motility are normal (WHO, 2010)
- Antagonist protocol
- Agree to have ≤ 2 embryos transferred
- Not participating in another IVF study at the same time
Exclusion Criteria:
... | ICSI Versus Conventional IVF in Non-male Factor Couples | NCT03428919 | Contradiction |
1,702 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
1. Self identified South Asian (Asian Indian, Bangladeshi, Pakistani, Sri Lankan)
residents of Harris, Fort Bend, Brazoria and Galveston counties.
2. 18 years of age or older
3. Those who speak the languages (including English) that had been identified a... | Health and Cancer Issues in the South Asian Community | NCT00479830 | Entailment |
1,218 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
Inclusion/Exclusion criteria for Part A
- Must provide informed consent
- Males and females, age 18 years and older
- Evidence of lung disease by at least one of the following:
1. symptoms consistent with pulmonary disease;
... | Lung Disease Collection (Qatar): Evaluation of the Lungs of Individuals With Lung Disease | NCT00504738 | Entailment |
4,519 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Patients suffering from benign uterine pathology (uterine fibromatosis, abnormal blood
loss, complex hyperplasia with atypia, uterine prolapse) with indication for total
uterine hysterectomy
- Uterine size </= than 15 cm
- American Soci... | Can 3D Laparoscopy Improve Surgical Performances in Surgeons in Training? | NCT04209036 | Contradiction |
5,473 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:Clinical diagnosis of Menorrhagia
- Must be able to swallow tablets
Exclusion Criteria:
- Endometrial abnormality
- Pelvic infection
- Pregnancy
- Breast Feeding
- Requirement for birth control
- Known intole... | The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders | NCT00904709 | Entailment |
6,028 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Subject age ≥ 18 years old
2. Subject received an explanation about the nature of the study and agrees to provide
written informed consent.
3. The subject was referred for pH monitoring procedure to detect acid reflux for at
least one of ... | Development of Applications of the Bravo® pH Monitoring System and Evaluation of Its Performance (Encore) | NCT01788085 | Entailment |
3,672 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
Patients:
• Patients ≥5 years of age undergoing surgery at Mbale Regional Referral Hospital, who
receive post-operative care in one of four main surgical wards, with a family carer
prepared to participate in the trial intervention.
Carers:
- All... | Family SuppleMented pAtient monitoRing afTEr suRgery: A Pilot Trial | NCT04341558 | Entailment |
2,400 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Patients with > 20% deficit in isometric quadriceps and/or hamstrings strength
- Patients willing to complete at least 9 BFRT training sessions
- Patients willing to provide informed consent (or parental consent)
Exclusion Criteria:
- Pregna... | BFRT for Severe Lower Extremity Muscle Atrophy | NCT04357184 | Entailment |
4,515 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Are capable of giving informed consent and complying with study procedures;
2. Are between the ages of 18 and 55 years, inclusive;
3. Female subjects have a negative serum hCG or urine pregnancy test result at screening
and Day -1, and meet one of the... | A Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study of TLL018, With Food Effect, in Healthy Participants | NCT04243083 | Contradiction |
3,957 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
Meets the diagnosis criteria of knee osteoarthritis. Age between 45 and 70 years. Meets
imaging examination X-ray Kellgren and Laerence classification standards grade I-III.
Patients who meet the criteria for early or mid-term stage of knee osteoarthritis.
Disconti... | Clinical Protocol of Sensitized Acupoint Changes in Knee Osteoarthritis Patients | NCT03599180 | Entailment |
655 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Mother-infant pairs, between 35 weeks and 41 completed weeks of pregnancy, planned to
deliver through vaginal or Elective lower segment cesarean section(ELSCS)
Exclusion Criteria:
- Women with multiple gestation
- Complications like pregnan... | Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants | NCT01081977 | Contradiction |
4,770 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- mild to moderate sensorineural hearing loss
- tinnitus (THI > 20)
- first user
Exclusion Criteria:
- profound hearing loss
- conductive hearing loss
- THI < 20
No condition on gender to be admitted to the trial.
Accep... | The Influence of the Sound Generator Combined With Conventional Amplification for Tinnitus Control: Blind Randomized Clinical Trial | NCT01857661 | Entailment |
672 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Apparently healthy male volunteers (21 - 45 years old)
- C-reactive protein (CRP) < 5 mg/L
Exclusion Criteria:
- Blood donation or significant blood loss (e.g. surgery) within the past 4 months
- Regular intake of iron and other nutrient sup... | Effect of Red Meat Intake on Occurrence of Serum Non-transferrin Bound Iron (NTBI) | NCT03019393 | Contradiction |
6,493 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Subjects must be between 18-70 years old
- Subjects with papulopustular rosacea graded moderate to severe (2 or 3) according to
the physician global Assessment, and with lesions on the cheeks.
- Prior stop of any topical treatment antibiotic, retino... | RosaC-RF : Bipolar Radiofrequency vs Doxycycline in Rosacea | NCT02204254 | Entailment |
2,906 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Consecutive patients diagnosed with definite, probable, or probable laboratory
supported ALS
- Disease duration from first symptoms between 6-24 months to exclude slow and fast
progression
- ALSFRS-R ≥ 30
- FVC (%predicted) ... | Exercise and Disease Progression in Amyotrophic Lateral Sclerosis Patients | NCT03326622 | Entailment |
6,898 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
Inclusion Criteria for All Subjects:
- Male or female aged 50 to 85 years, inclusive.
- Female subjects must be documented by medical records or physician's note to be either
surgically sterile (by means of hysterectomy, bilateral oophorectomy, or tubal
... | Evaluation of [18F]APN-1607 PET Uptake in Alzheimer's Disease Patients Compared With Healthy Subjects | NCT04141150 | Entailment |
1,559 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Diagnosis of carpal tunnel syndrome
- Completion of a nerve conduction velocity study (NCVS) within the past twelve months
or a physician waiver of the NCVS
- Able to type using all fingers on the keyboard
Exclusion Criteria:
- ... | Study Protocol for CTS and Keyboard Controlled Randomized Trial | NCT02101294 | Contradiction |
4,449 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- symptoms of tennis elbow for at least 3 months
- clinical diagnosis of tennis elbow
Exclusion Criteria:
- significant symptom improvement in previous month
- receipt of any active treatment for the condition in the previous month
... | Effectiveness of Microcurrent for Treatment of Tennis Elbow | NCT00817232 | Contradiction |
5,098 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Postmenopausal for 5 or more years, defined as no menses for at least 5 years OR at
least 5 years status post bilateral oophorectomy
- Bone mineral density T-score at the hip or spine of -2.0 or less
- Spinal anatomy suitable for dual-energy x-ray a... | A Study to Examine the Effects of an Experimental Drug on Postmenopausal Osteoporosis (MK-0822-004) | NCT00112437 | Contradiction |
5,491 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
Patients must meet all of the following criteria in order to be eligible for enrollment:
1. Criteria for diagnosis of giant cell arteritis (GCA), Takayasu's arteritis (TAK),
polyarteritis nodosa (PAN), granulomatosis with polyangiitis (GPA, Wegener's), microscopic
p... | Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis | NCT03482479 | Contradiction |
5,898 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Patients with functional dyspepsia that fulfill Rome III criteria with inadequate
relief of dyspeptic symptoms
- Age >18
- Provision of written consent
Exclusion Criteria:
- Presence of organic pathology identified by upper endo... | BRAVO Study for Functional Dyspepsia | NCT01349413 | Contradiction |
6,255 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients with signed informed consent.
- Patients with a positive PCR test for SARS-CoV-2 or influenza H1N1 test upon emergency
department admission.
- Patients with lung CT within 24hrs of specimen collection for PCR test.
- Patients wi... | Tomographic Findings in COVID-19 and Influenza H1N1 | NCT04499378 | Contradiction |
1,818 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- adult patients (≥18 years of age) who are undergoing esophago-gastro duodenoscopy
(EGD) for any reason and are consenting to be enrolled in the study during the study
period.
Exclusion Criteria:
- the patients who cannot speak English in C... | Japanese Upper GI Symptoms Compared With Iranian and Canadian Patients Presenting | NCT03868267 | Entailment |
4,206 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Diagnosis of cystic fibrosis, confirmed by the sweat test;
- 14 - 25 years;
- Clinical stability;
- Absence of bacterial colonization for 4 weeks;
- Both sexes;
Exclusion Criteria:
- Inability to perform the protocol ... | Inspiratory Muscle Training in Individuals With Cystic Fibrosis | NCT03737630 | Contradiction |
6,886 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Patients diagnosed with new or previous mild or moderate Alzheimer's disease diagnosed
by a doctor according to medically-accepted definitions
- Patients living in ordinary households (for example in their own home or in the home
of a family member... | A Survey Study of the Treatment and Outcome Management in Patients Diagnosed With Alzheimer's Disease | NCT00291421 | Entailment |
252 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Healthy, women ages 18 to 39yo with BMI <30
- Regular menstrual cycles with duration between 24-35 days
- Completion of screening visit where ovulation will be assessed with blood draw for
progesterone level (must be 5ng/mL or greater)
- ... | Application for the Etonogestrel/Ethinyl Estradiol Ring | NCT03120728 | Contradiction |
3,320 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- A healthy male adult at the age of 20 to 45 (both inclusive) at the time of screening
test.
- Body weight equal to or greater than 55 kg and calculated ideal body weight (IBW)
within ±20%
- An individual who has been given and fully und... | A Study to Evaluate the Effect of Food on Fixed-Dose Combination of MP-513 10 mg and Metformin XR 750 mg | NCT03787043 | Contradiction |
2,073 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Thoracocentesis
- Chest X-ray
- CT scanning
- PET-CT scanning
Exclusion Criteria:
- Missing data
- Lung cancer
- Thoracic malignancies
No condition on gender to be admitted to the trial.
Subject must be a... | The Value of PET-CT in Pleural Effusions | NCT03272997 | Entailment |
4,662 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | - INCLUSION CRITERIA:
Healthy volunteers will be in excellent health.
Only women with regular menstrual cycles (every 26-35 days) using mechanical (condoms,
diaphragm) or sterilization methods of contraception will be included.
Only women with a negative pregnancy test, normal physic... | Hormonal Effects on the Uterus and Endometrium | NCT00001454 | Entailment |
2,378 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Age 7 or older; must be wheelchair-dependent
- Confirmed Dystrophin mutations based on mutation compatibility with micro-dys cDNA
based on previously published methods.
- Males of any ethnic group will be eligible.
- Ability to cooperate... | Clinical Intramuscular Gene Transfer Trial of rAAVrh74.MCK.Micro-Dystrophin to Patients With Duchenne Muscular Dystrophy | NCT02376816 | Entailment |
4,539 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Females aged below 40 years old.
2. Screened by inquiry and diagnosed as primary dysmenorrhea by gynaecologist with pelvic
ultrasonography.
3. Female subject who is:
- using adequate contraception since last menstruation and no plan f... | Effectiveness of Nanoone Woman Underwear Using in the Management of Dysmenorrhea | NCT01449305 | Contradiction |
4,013 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Symptomatic knee OA for at least 6 months
- Fulfilled American College of Rheumatology clinical criteria for OA of the knee
- Radiographically assessed OA of the knee graded 1-4 according to the Kellgren &
Lawrence scale
Exclusion Criteria:... | Measurement of Gait Spatio-Temporal Characteristics in Knee Osteoarthritis Patients | NCT00599729 | Entailment |
4,348 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- age 18 - 65
Exclusion Criteria:
- regular use of analgesics
- known hypersensitivity of local anaesthetic
- renal-, heart- or liver disease
- known peripheral neuropathy or diabetes mellitus
- local infection on injec... | The Influence of Lidocaine Volume on Discomfort During Administration of Local Anesthetic | NCT02086292 | Entailment |
4,682 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Participant must be 18 to 55 years of age inclusive, at the time of signing the
informed consent
- Participants must be overtly healthy as determined by medical evaluation including
medical history, physical examination, laboratory tests, ECG, bloo... | A Trial to Learn What Happens to Different Medicinal Forms of BAY2328065 When They Enter the Body and How Safe They Are in Healthy Male and Female Participants | NCT04851483 | Entailment |
3,714 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- ethnic Chinese;
- aged 50 years or above;
- ability to comprehend Chinese;
- fulfilling any 3 of the following criteria: i. morning stiffness ≤ 30 min; ii.
crepitus on active joint motion; iii. bone tenderness; iv. bone enlargement; or v... | Self-administered Acupressure for Knee Osteoarthritis in Middle- and Older-Aged Adults | NCT04191837 | Contradiction |
204 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Diagnosis of idiopathic hypogonadotropic hypogonadism (IHH) or Kallmann syndrome
(KS)Adult male 18-65 years of age
- Serum testosterone <100 ng/dL
Exclusion Criteria:
- No specific exclusion criteria
Male
No healthy subjects accepted to joi... | Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadism | NCT00493961 | Entailment |
195 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Male, ages 18-68
- Serum total testosterone less than or equal to 275 ng/dL
Exclusion Criteria:
- Significant intercurrent disease of any type, in particular, liver, kidney or heart
disease, uncontrolled diabetes mellitus or psychiatric ill... | Pharmacokinetic Study of Oral Testosterone (T) Ester Formulations in Hypogonadal Men | NCT00695110 | Entailment |
544 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- In-vitro fertilization patients at the investigators' institution, intended to undergo
a transfer of a frozen five-day embryo (blastocyte)
- 18 to 39 years old
- First to third treatment cycle
- Patient has previously had a maximum of fo... | Assisted Hatching in Frozen Blastocysts | NCT03833869 | Contradiction |
5,631 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- 13-16 years old,
- overweight or obese (weight for height >20% over normality)
Exclusion Criteria:
- mental health problems, long term illnesses.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject... | Promoting Overweight Adolescents Physical Activity | NCT02295761 | Contradiction |
5,352 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Key Inclusion Criteria: Qualified participants must meet all of the following inclusion
criteria.
1. Female age 30 to 50 years
2. Excessive menstrual bleeding due to benign causes
3. Uterine sounding depth measurement of 6.0 - 12.0 cm
4. A minimum uterine cavity lengt... | Minitouch Endometrial Ablation System Treatment for Menorrhagia: An Evaluation of Safety & Effectiveness | NCT04267562 | Contradiction |
6,123 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Individuals who work within a food production, healthcare, research or clinical
organization.
- Asymptomatic as per daily screening.
- No contraindication to performing a NP swab.
Exclusion Criteria:
- Any individual with fever,... | A Research Platform to Screen Healthcare Workers | NCT04574765 | Contradiction |
6,613 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Ability to provide written informed consent or have a legally authorized
representative provide written informed consent
- Subjects who are 18-55 years of age
- Subjects must be willing and able to comply with study procedures
- HbCO<3% ... | SpO2 System Accuracy Testing With Different Sensors | NCT01613222 | Contradiction |
5,182 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- At least 7 years post-menopause
- Serum 25OHD level 5 ng/ml to 20 ng/ml
- BMI less than or equal to 40 kg/m2
- Willing to discontinue multivitamins that contain vitamin D during the study
Exclusion Criteria:
- Cancer (except basa... | Vitamin D Supplementation in Older Women | NCT00472823 | Entailment |
4,304 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
absence of sperm cells on 2 spermograms in 3 months interval testicular size has to be
determined in order to categorized in a group to accept surgery-
Exclusion Criteria:
allergy to fluoro deoxyglucose clinical varicocele
Male
Accepts Healthy Volunteers
Subject mu... | Secretory Azoospermia and FDG (Fluoro Deoxyglucose) PET-CT | NCT02043444 | Entailment |
312 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Be healthy women, who are sexually active, at risk for pregnancy, and desiring
contraception.
- Be within the age range of 18 through 35 (inclusive) at enrollment if not in the
subset of women with an age of 36-45 at enrollment (age subset at selec... | Study of Contraceptive Efficacy & Safety of Phexxi™ (Previously Known as Amphora) Gel Compared to Conceptrol Vaginal Gel | NCT01306331 | Contradiction |
6,464 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Bilaterally symmetric red skin on cheeks Caucasian Age 18-60 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years | Topical Agent for Treatment of Red Skin | NCT00279890 | Entailment |
130 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. Premature appearance of secondary sexual characteristics: girls present with
development of secondary sexual characteristics before 8, with breast induration as
the earliest manifestation.
2. Accelerated linear growth: the annual growth rate is high... | Study of Comprehensive Diagnosis and Treatment for Children Precocious Puberty | NCT02920515 | Contradiction |
6,611 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- This study has 2 Phases. In Phase 1, healthy, non-smoking adult volunteers greater than
18 years of age are invited to participate. In Phase 2, all adult (>18) non-critical
patients and healthy community volunteers visiting the ED at VH and UH are eligible to
parti... | Calibration and Validation of High Quality Low-Cost 3D Printed Pulse Oximeter | NCT02846974 | Contradiction |
2,074 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
1. Patient ≥ 18 years of age
2. Admitted to ICU in the last 72 h
3. Definite or probable IPF diagnosis defined on 2018 ATS/ERS/JRS/ALAT guidelines or a
possible usual interstitial pneumonia pattern on HRCT without etiology.
4. Definite AE-IPF ... | Therapeutic Plasma Exchange, Rituximab and IV Ig for Severe Acute Exacerbation of IPF Admitted in ICU | NCT03584802 | Entailment |
5,683 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Children evaluated for short stature
- Normal weight \ overweight \ obesity
Exclusion Criteria:
- Known GH deficiency
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at... | Growth Hormone Secretion Following the Anaerobic Exercise | NCT01934270 | Entailment |
3,309 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Inclusion Criteria:
- clinical diagnosis of oculocutaneous albinism
- age over 3 and weight over 25 lbs.
Exclusion Criteria:
- ocular only albinism
- ocular pathology other than albinism
- neurologic disease, history of myocardial infarction, history ... | Vision Response to Dopamine Replacement | NCT01663935 | Entailment |
6,290 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
Patients With confirmed COVID-19
Exclusion Criteria:
inadequate sample of the patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years | To Access the Egyptian COVID-19 Whole Genome by NGS and Compare to the International Worldwide Database | NCT04346043 | Entailment |
4,425 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
1. age 18-65 years
2. diagnosis of CLE, confirmed by the PI using clinical symptoms and exam findings of
tenderness over the lateral epicondyle and/or extensor tendon, and pain on 2 extensor
muscle provocation tests
3. self-reported CLE-rela... | Efficacy of Injection Therapy for Lateral Epicondylosis | NCT01476605 | Contradiction |
700 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | No eligibility criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 100 Years | Hemochromatosis and Iron Overload Screening Study (HEIRS) | NCT00005541 | Entailment |
2,910 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Key Inclusion Criteria:
1. Able to comprehend and willing to sign an Informed Consent Form (ICF)
2. Males or females 18 years of age or older
3. A diagnosis of familial or sporadic ALS (defined as meeting the possible,
laboratory-supported probable, probable, or definite cr... | A Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) | NCT01378676 | Entailment |
5,688 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Children with short stature by growth hormone deficiency(GHD) or idiopathic short
stature (ISS) or turner's syndrome(TS) or small for gestational age(SGA)
- Children who has official height record at least 6 months prior
Exclusion Criteria:
... | Long-term Safety and Effectiveness of Growtropin®-II Treatment in Children With Short Stature | NCT04798690 | Entailment |
5,226 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion criteria:
- fracture caused by osteoporosis
- fifty years or more of age
- informed consent
Exclusion criteria:
- Physically or mental state that does not participation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to joi... | Osteoporosis School | NCT00224991 | Entailment |
764 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Male or female higher than 18 and less or equal to 65 years of age
2. an active life-style, professional or regular casual sport player (people who plays
sport or trains themselves at least 2-3 times per week).
3. diagnosis of knee osteoarthritis will... | Efficacy and Safety of Hymovis ONE® (32mg/4ml) Intrarticular Injection in Active Patients With Knee Overuse Syndrome | NCT04661111 | Contradiction |
6,675 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Male
- Severe hemophilia A or moderate hemophilia A
- 1-12 years of age
- Requiring treatment with FVIII
Exclusion Criteria:
- Current or prior inhibitor or familial antecedents of inhibitor
- Surgery required during ... | Russian Kogenate Pediatric Study | NCT00632814 | Contradiction |
6,825 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | - Male, at least 12 years old, with severe hemophilia A undergoing major elective major
surgery requiring FVIII replacement for at least 6 days. Negative FVIII inhibitor test
at screening and no past history of inhibitor.
- Previously treated with at least 150 exposure days to any... | Study Evaluating B-Domain Deleted Recombinant Factor VIII (BDDrFVIII, ReFacto AF) in Patients With Hemophilia A Undergoing Elective Major Surgery | NCT00243659 | Entailment |
3,552 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Patients with verified Addison's disease on stable treatment.
Exclusion Criteria:
- Insulin treated Diabetes Mellitus, cardiovascular disease,malignant disease,
pregnancy.
- Treatment with glucocorticoids or drugs that interfere with cortis... | Glucocorticoid Treatment in Addison's Disease | NCT01063569 | Entailment |
1,094 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Adult patients 40 years of age or older who present to the Emergency Department with
syncope or presyncope.
- Subjects must read and speak English or Spanish.
- Subjects must have a working phone number and fixed address.
Exclusion Criteria... | Practical Approaches to Care in Emergency Syncope | NCT04533425 | Contradiction |
3,979 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Symptomatic idiopathic osteoarthritis of the knee for a minimum of six months duration
requiring treatment with either an analgesic or anti-inflammatory agent on a regular
basis (greater than or equal to three days/week) for at least three months.
-... | A Four-Week Study Comparing Acetaminophen Extended Release and Rofecoxib in the Treatment of Osteoarthritis of the Knee | NCT00568295 | Entailment |
426 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Infertile patients with clear fertility desires
2. Diagnosed with thin endometrium or endometrial scarring for whom drugs and surgical
interventions were ineffective
3. 20-42 years old
4. Normal ovarian function or with frozen embryos
... | The Efficacy and Safety of Collagen Scaffold Loaded With Umbilical Cord Derived Mesenchymal Stem Cells in Infertile Women With Thin Endometrium or Endometrial Scarring | NCT03592849 | Contradiction |
6,412 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Adults age 18 or older
- Tested positive for SARS-CoV-2 by RT-PCR assay using a respiratory tract sample
(either nasopharyngeal swab OR oropharyngeal swab OR nasal aspirate OR
tracheobronchial aspirate OR saliva) collected within 72 hours of random... | The Prevent Severe COVID-19 (PRESECO) Study | NCT04600895 | Entailment |
2,409 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Male
- Age 7 years to 100 years
- Ability to ambulate for 10 meters. Assistive devices are allowed.
- Diagnosis of DMD confirmed by at least one the following:
- On stable dose of prednisone, prednisolone or deflazacort for at least 12 mo... | Study of Daily Pentoxifylline as a Rescue Treatment in Duchenne Muscular Dystrophy | NCT00243789 | Entailment |
4,611 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Women aged 18-50 years, inclusive
2. General good health, by volunteer history and per investigator judgment
3. History of regular menstrual cycles of 24-35 days (inclusive), by volunteer report
4. History of Pap tests and follow-up consistent with stan... | Safety and Acceptability Study of a Non-Hormonal Ring | NCT03598088 | Entailment |
5,654 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Ages 13-17
- Male and female
- Living with at least one parent or guardian who is willing to participate in treatment
- A BMI percentile >85% for gender and age (e.g., overweight or at risk for overweight)
Exclusion Criteria:
- C... | Parent-Based Treatment for Pediatric Overweight | NCT00807560 | Contradiction |
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