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3,807 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Males and females between 40 and 75 years of age, inclusive
2. BMI between 18.5 to 29.9 kg/m2, inclusive
3. Female participant is not of child-bearing potential, defined as females who have
undergone a sterilization procedure (e.g. hysterectomy, bilat... | Safety and Efficacy of JointAlive™ on the Knee-joint Function in Adults With Knee Arthritis | NCT04395547 | Entailment |
6,306 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients newly diagnosed with COVID-19 at hospital setting or community screening,
confirmed with biological proof (RT-PCR)
Exclusion Criteria:
- Subjects opposed to the use of their data
- Minors, adults under guardianship, protected perso... | COVID-19, Aging, and Cardiometabolic Risk Factors Study | NCT04802044 | Entailment |
5,248 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
1. A diagnosis in accordance with Criteria for the Diagnosis of Primary Osteoporosis.
2. Other inclusion criteria as specified in the study protocol.
Exclusion Criteria:
1. Patients having secondary osteoporosis or another condition that presents low bone
... | Controlled Study of ONO-5920 in Patients With Involutional Osteoporosis in Japan | NCT00212719 | Entailment |
4,604 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Being between the ages of 18 and 45,
- PCR test result positive confirmed having COVID-19 infection,
- Women had at least one period of Menstrual cycle after COVID-19
- Being an Internet connection,
- To be able to speak and write in Turk... | Menstrual Cycle-induced Pain, Fatigue and Anxiety in Women Suffered From COVID-19 | NCT04806815 | Entailment |
6,202 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Adult patients with a differential diagnosis of COVID-19
Exclusion Criteria:
- Patients who are under 18 year-old
- Patients who have not either Thorax CT or SARS-CoV-2 RT-PCR
No condition on gender to be admitted to the trial.
No healthy subjects accep... | Decision Support System Algorithm for COVID-19 Diagnosis | NCT04479319 | Contradiction |
2,564 | 19 | A 7-year-old girl is brought to the emergency department by her parents for generalized rash. The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll. Her mother suspects that something had stung her. The patient's blood pressure ... | I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. Th... | - INCLUSION CRITERIA:
Males and females, age 3 months to 19 years old, (less than 18 years old).
Individuals referred to the NIH with a diagnosis of asthma, rhinitis, anaphylaxis,
urticaria, atopic dermatitis, food allergy, stinging insect allergy or other
allergic/inflammatory diseas... | Clinical and Immunological Evaluation of Children With Allergies | NCT00102570 | Entailment |
4,489 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Female subject, between the years 18-30, at the time of consent.
2. Subject is willing to participate and is capable of giving informed consent. (Note:
Consent must be obtained prior to any study-related procedures.)
3. Subject must be willing to comp... | Alternating Urine Redox Status Of Consecutive Menstrual Cycles | NCT04157309 | Contradiction |
4,962 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Able to Sign written informed consent in Hebrew.
- Patient agrees to attend all treatment procedures and follow-up evaluations and is
willing and able to comply with all study requirements.
- Patient with a clinical diagnosis of idiopathic PD, or ET... | The Essential Tremor (ET) and Parkinson Disease (PD) Tremor Acute Stimulation Study | NCT01940406 | Entailment |
201 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Symptomatic testosterone deficiency
- Intend to undergo testosterone therapy at Men's Health Boston
- Total testosterone <350ng/dL or free testosterone <1.5ng/dL
Exclusion Criteria:
- Type 1 diabetes
- Use of exogenous testostero... | Metabolomics During Testosterone Therapy | NCT01963390 | Entailment |
2,525 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- Children with eczema who visit UNC pediatric dermatology during study enrollment
(Summer 2018).
- Currently on a class 1 topical steroid or systemic immunosuppressive agent to control
his/her eczema at the time of recruitment.
- A histo... | Bleach vs. Bubbles: Assessing the Impact of the Bathroom Environment on Eczema | NCT03619161 | Entailment |
4,399 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- aged between 18 and 65 years
- presence of elbow pain lasting for less than three months
Exclusion Criteria:
- history of acute trauma or fracture on forearm
- congenital or acquired elbow deformities
- demyelinating diseases
... | Bracing or Kinesio Taping in The Management of Lateral Epicondylitis | NCT04498533 | Contradiction |
269 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Indications for IVF/ICSI include male factor, diminished ovarian reserve, tubal
factor, ovulatory dysfunction and unexplained infertility.
Exclusion Criteria:
- none
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must ... | Luteal Phase Estradiol Support for In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles | NCT02677259 | Contradiction |
560 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Caucasian subjects of either gender (male or female) with an age between 18 and 45
years (both inclusive).
2. Medical history and physical examination with no relevant abnormal findings.
3. No evidence of significant disease (organic or psychiatric) b... | Bioavailability and Safety of Two Oral Fixed Dose Preparations Containing 18 mg Ivermectin (IVM 18 MG TABLETS, LICONSA S.A., Spain) Versus Reference Dosing (Weight Based) Containing 6 mg Ivermectin (REVECTINA®, Abbott Laboratórios do Brasil Ltda, Brazil) | NCT03173742 | Contradiction |
2,568 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- bilateral inguinal hernia
Exclusion Criteria:
- American Society of Anaesthesiology score >3
- complicated inguinal hernias
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Laparoscopic vs Open Bilateral Inguinal Hernia Repair | NCT04679116 | Contradiction |
2,964 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Definite ALS.
Exclusion Criteria:
- Primary Lateral Sclerosis (PLS)
- Other forms of motor neuron disorders.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
| Quantitative Neuromuscular Ultrasonography in Amyotrophic Lateral Sclerosis (ALS) | NCT02507713 | Entailment |
1,334 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion criteria of Cohort 1- Newborn:
- Subjects aged 1-2 days
- Subjects with gestational age 37-42 weeks
- Subjects with stable clinical status (admitted to normal newborn nursery)
Inclusion criteria of Cohort 2 - Older children:
• Subjects aged 0-18 years
... | Genetic and Metabolic Disease in Children | NCT02650622 | Contradiction |
2,497 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- the ability to speak English and/or Mandarin, have adequate hearing with/without
hearing aids to respond to normal conversation, not currently undergoing regular
assessment/care with an ophthalmologist (at least yearly), have the ability to undergo
... | Randomized Controlled Trial Evaluating an Incentive-based Community Eye-care Programme | NCT03264885 | Entailment |
6,710 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Prevention Trial, Inclusion Criteria:
- Male children >/= 4 months of age.
- Severe hemophilia A (FVIII < 0.01 U/ml)
- No previous bleed or surgery requiring treatment (except circumcision)
- No previous factor VIII product (except for circumcision)
- Willingn... | Hemophilia Inhibitor Clinical Trials (INHIBIT) Platform | NCT02196207 | Contradiction |
1,134 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | No eligibility criteria
Male
No healthy subjects accepted to join the trial.
Subject must be at most 100 Years | Genetic Analysis of Familial Hypertrophic Cardiomyopathy | NCT00005251 | Entailment |
2,225 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
More than 18 years old Able to sign informed consent Indication of long-term treatment with
allopurinol Acute gout crisis
Exclusion Criteria:
Les than 18 years-old Unable to consent Contra-indication to allopurinol
No condition on gender to be admitted to the trial... | Allopurinol in Acute Gout | NCT01775098 | Entailment |
1,187 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Diagnosis of histologically or cytologically documented, malignant pleural effusions
(primary non-small-cell lung carcinoma, mesothelioma, and other histologies), who have
free pleural space (partial or total) that permits the intrapleural drug instillation.
... | Intra-pleural Administration of GL-ONC1, a Genetically Modified Vaccinia Virus, in Patients With Malignant Pleural Effusion: Primary, Metastases and Mesothelioma | NCT01766739 | Entailment |
6,745 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Male and female hemophilia A patients.
- Patients for whom the decision to treat with Kovaltry was determined prior to
enrollment in the study.
Exclusion Criteria:
- Patients participating in an investigational program with interventions ou... | Drug Use Investigation of Kovaltry in Hemophilia A Patients | NCT02941783 | Contradiction |
73 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria: hypogonadotropic hypogonadism
- decreased serum testosterone concentration below the normal range (serum T <
300ng/dL),
- FSH and LH levels within or below the normal range,
- absence of a pituitary or hypothalamic mass lesions on MRI, presence of gon... | Effects of Medications in Patients With Hypogonadism | NCT01601327 | Contradiction |
5,061 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Elderly subjects (> or equal to 65 years old)without any disease mentioned in the
exclusion criteria.
- BMI ≥ 25Kg/meters squared
Exclusion Criteria:
- Exclusion criteria include: diabetes, subjects with impaired glucose tolerance on
... | Hypovitaminosis D : A Link Between Bone/Mineral and Fat/Fuel Metabolism | NCT01315366 | Contradiction |
3,759 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Knee-OA detected by x-ray (Kellgren & Lawrence grade 1 or greater)
- KOOS4 of ≤ 75
- Considered not to be a candidate for Total Knee Replacement (TKR) by the orthopedic
surgeon.
- The participant is > 18 years of age.
- The p... | Structured Non-operative Treatment of Knee Osteoarthritis | NCT01535001 | Contradiction |
6,445 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Moderate to severe erythematotelangiectatic rosacea with moderate to severe erythema
of facial lesion
- Generally healthy excluding rosacea
- Presence of telangiectasia
- Five or less facial inflammatory lesions
- Able to res... | A Study of Laropiprant (MK-0524) in Participants With Moderate to Severe Erythematotelangiectatic Rosacea (MK-0524-155) | NCT01451619 | Entailment |
5,067 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- A woman between 60 and 75 years of age with a medical diagnosis of osteoporosis by
means of a femur or lumbar densitometry of less than 2.5 standard deviations (SD) of
peak bone mass.
- No history of previous fracture in the last 10 years.
... | EFFECT OF FLOW RESTRICTION ON BONE QUALITY WITHIN A MULTICOMPONENT EXERCISE PROGRAM FOR OLDER WOMEN WITH OSTEOPOROSIS. | NCT04760145 | Contradiction |
5,105 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
1. postmenopausal women (normally over 50 years old and years since menopause over than 1
year) in Peking.
2. participants without any fracture in 2007 PK-VF study were included in the prospective
study investigating the association of bone turnover ma... | A 5-Year Follow-up Study Investigating Factors Associated With Osteoporotic Fracture in Chinese Postmenopausal Women | NCT02247011 | Contradiction |
243 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Women aged 18-50 years, inclusive
2. General good health, by volunteer history and per investigator judgment
3. History of regular menstrual cycles of 24-35 days (inclusive), by volunteer report
4. History of Pap tests and follow-up consistent with stan... | Safety and Acceptability Study of a Non-Hormonal Ring | NCT03598088 | Contradiction |
6,299 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Age >=18 years
- Positive test for SARS-CoV-2
Exclusion Criteria:
- Due to the non-interventional design of the registry there are no specific exclusion
criteria.
No condition on gender to be admitted to the trial.
No healthy subjects accep... | Austrian COVID-19 Registry | NCT04351529 | Entailment |
2,825 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Definite ALS
Exclusion Criteria:
- Primary Lateral Sclerosis (PLS)
- Other forms of motor neuron disorders
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
| Ultrasonography of the Neuromuscular Degeneration Behavior in Amyotrophic Lateral Sclerosis | NCT03683875 | Entailment |
6,527 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Males aged 12 to 70 years
- Subjects with severe hemophilia A (< 1% factor VIII [FVIII]:C)
- Subjects with equal or greater than 150 exposure days (EDs) with any FVIII in total
- Subjects who have been on-demand treatment with a minimum of 1 relevant... | BAY79-4980 Compared to rFVIII-FS in Previously Treated Patients With Severe Hemophilia A | NCT00623727 | Contradiction |
1,020 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Patients with unilateral and bilateral knee OA
- O.A with grade 2-3(Kellgren and Lawrence system for classification of osteoarthritis
of knee)
- Experiencing Pain for more than 1 month
Exclusion Criteria:
- Rheumatic diseases, i... | Effects of Kinesio-taping in Knee Osteoarthritis Patients. | NCT04585373 | Entailment |
1,122 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Syncope of uncertain etiology or
- Pre-syncope of uncertain etiology or
- Palpitations of uncertain etiology or
- Management of known AF/SVT patients
Exclusion Criteria:
- Any abnormal or friable skin over the anterior thorax and... | The Simple ECG Monitoring Trial (Comparison of a Novel Recording System With a Standard Holter Monitor) | NCT01382953 | Entailment |
2,067 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Patients with a confirmed diagnosis of Pulmonary Fibrosis
- Patients had to be medically stable to participate in such a programme
Exclusion Criteria:
- Any orthopaedic or neurological condition affecting mobility
- If they required oxygen t... | Effects of Pulmonary Rehabilitation on Functional and Health Status Measures in Pulmonary Fibrosis | NCT03542318 | Entailment |
4,666 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Have the indication for hysterectomy for a supposed benign uterine disease
- Have a giant uterus of 500g or more
- Estimation of uterine weight more than 500g
- Uterine myoma size at 4 months or more after pregnancy due to pelvic examination
... | Comparison of TLH and LAVH With Over Than 500g | NCT03146299 | Entailment |
185 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Male subjects with a prior documented definitive diagnosis of hypogonadism as
evidenced by previously documented:
- Hypothalamic, pituitary or testicular disorder or age related idiopathic
hypogonadism
- Screening serum t... | A Titration Trial to Determine the Effectiveness of Testosterone MD-Lotion (Cutaneous Solution) Formulations | NCT00702650 | Entailment |
2,753 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Clinical diagnosis of inguinal hernia
Exclusion Criteria:
- Femoral hernia
- Emergency cases
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at mo... | Effectiveness of Topical Antibiotic Prophylaxis in Inguinal Hernia Repair | NCT01273818 | Entailment |
3,601 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Anyone over the age of 18 with a generalized complaints able to provide consent
Exclusion Criteria:
- Anyone under 18 yrs and anyone with a very specific, system based complaint.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to jo... | Utility of the History and Physical Exam in the Emergency Department | NCT01154517 | Contradiction |
6,826 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- hemophilia A, any severity, with documented history of high-titer inhibitor (>5BU);
current use of bypassing agents (PCCs, aPCCs or rFVIIa) for treatment of bleeds; >/= 6
bleeds requiring bypassing therapy in the previous 6 months
Exclusion Criteria:
... | Efficacy Study of Activated Prothrombin Complex for Prevention of Bleeds in Hemophilia A With Inhibitors | NCT00221195 | Entailment |
2,617 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Patients who underwent inguinal hernia repair with the 3D dynamic responsive device
named ProFlor
- Patients undergoing recurrent inguinal hernia repair after primary repair with the 3D
dynamic responsive device named ProFlor
- Patients... | Neo-angiogenesis in Inguinal Henia Implant ProFlor | NCT04541316 | Contradiction |
3,079 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- students with ID (mild category) aged 8-18 years old from special education schools
including primary and secondary schools;
Exclusion Criteria:
- students without physical disability.
No condition on gender to be admitted to the trial.
No healthy subj... | Effectiveness of Active Video Games in Children With Intellectual Disabilities | NCT04277130 | Entailment |
3,070 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- molecular documentation of FMR1 full mutation
- ages 6-17 yrs, inclusive
- sexually active subjects are required to use a medically acceptable form of birth
control
Exclusion Criteria:
- non-English or Spanish speaking subjects
... | Ganaxolone Treatment in Children With Fragile X Syndrome | NCT01725152 | Entailment |
3,258 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Demonstrates understanding of the study procedures, restrictions and willingness to
participate as evidenced by voluntary written informed consent and has received a
signed and dated copy of the informed consent form
- Good general and mental healt... | Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms | NCT02641912 | Entailment |
1,462 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Healthy Cohort:
132 individuals with no history of swallowing impairment or any health conditions known to
impact swallowing function will be included in this study to serve as a comparative control
group or reference standard group here and in future studies.
Inclusion criteria:
... | Improving Diagnostic Standards in Dysphagia | NCT04773184 | Entailment |
4,462 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Individuals with clinical evidence of lateral or medial epicondylitis of the elbow.
- Age 18 or higher
- Minimum of 4 on Question 5 of BPI
Exclusion Criteria:
- Peripheral neuropathy of any origin in the index limb
- Cubital tunn... | Study to Evaluate the Efficacy of the Synera Patch Compared to Naproxen Sodium for Epicondylitis of the Elbow | NCT01525043 | Contradiction |
3,743 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. ethnic Chinese;
2. aged 60 years or above;
3. ability to comprehend Chinese;
4. fulfilling any 3 of the following criteria: i. morning stiffness </= 30 min; ii.
crepitus on active joint motion; iii. bone tenderness; iv. bone enlargement; or... | Electromoxibustion and Knee Health Education for Knee Osteoarthritis in Older Adults | NCT04034394 | Contradiction |
4,524 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | - INCLUSION CRITERIA:
- healthy white women aged 21-42 who were planning to become
pregnant
-women enrolled in the 1982-1986 North Carolina Early Pregnancy
Study (EPS) at the time they discontinued all methods of birth control
Female
No healthy subjects accepted to join the trial... | Factors Influencing Fertility or Pregnancy Health | NCT04595760 | Contradiction |
5,188 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Aged between 55 and 85 years
- Postmenopausal (have not had any menses in the last 5 years)
- Have a bone mineral density scan (DXA) that can be evaluated at the spine AND at the
hip with a T-score equal to or below -2.5 at the spine or the femoral ... | PaTH Study: Parathyroid Hormone and Alendronate for Osteoporosis | NCT00005005 | Entailment |
6,589 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Females with severe (FVIII<0.01u/ml) or moderate (FVIII 0.01≤0.05 u/ml) hemophilia A
- Females with severe (FIX<0.01u/ml) or moderate (FIX 0.01≤0.05u/ml) hemophilia B
- Willingness to participate in the study.
Exclusion Criteria:
- Subjects ... | Females With Severe or Moderate Hemophilia A or B: an International Multi-center Study | NCT00936312 | Contradiction |
1,605 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
1. virgins.
2. Their age ranged from 18 to 25 years old
3. Their body mass index (BMI) ranged from 18 to 25 kg/m2.
4. They were clinically and medically stable during the study
5. Have regular menstrual cycle of 23 to 35 days duration
E... | Effect of Swimming on Premenstrual Syndrome | NCT03264612 | Contradiction |
6,614 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- 12 years of age or older (at least 18 years in Croatia, France and United Kingdom
(UK))
- Clinical diagnosis of congenital haemophilia A or B with a current positive inhibitor
titre and a known peak inhibitor of above 5 Bethesda units (BU) (present... | Haemophilia Patients With Inhibitors Being Treated for Acute Joint Bleeds | NCT00486278 | Contradiction |
5,187 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Clinical diagnosis of osteoporosis patients
Exclusion Criteria:
- Any previous use of parathyroid hormone or sodium fluoride, use of anabolic steroids
or growth hormone within 6 months before trial entry or oral or intravenous systemic
cor... | Kefir on Bone Mineral Density and Bone Metabolism in Osteoporotic Patients | NCT02361372 | Entailment |
5,199 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Ambulatory, postmenopausal women aged 55-85 years (at least 3 years have elapsed after
menopausal) are included at the time of entry into the trial. They have to be free of
severe or chronically disabling conditions other than osteoporosis.
- The p... | Comparison Medications in the Treatment of Postmenopausal Women With Osteoporosis | NCT00542984 | Entailment |
5,680 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Main Study Inclusion Criteria:
1. Pre-pubertal children aged ≥3 years , and not yet 11 years for girls or not yet 12
years with either isolated GHD, or GH insufficiency as part of multiple pituitary
hormone deficiency.
2. Confirmed diagnosis of GHD by two different GH pro... | Safety and Efficacy Phase 3 Study of Long-acting hGH (MOD-4023) in Growth Hormone Deficient Children | NCT02968004 | Contradiction |
1,670 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Is the individual a healthy, normal adult man and women who volunteers to participate?
- Is s/he within 18 and 45 years of age, inclusive?
- Is his/her BMI between 19 and 30, inclusive?
- Is she willing to avoid pregnancy by abstaining from sexual in... | Bioavailability Study of Dr. Reddy's Desloratadine Tablets, 5 mg Under Fasting Conditions. | NCT01314339 | Entailment |
2,565 | 19 | A 7-year-old girl is brought to the emergency department by her parents for generalized rash. The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll. Her mother suspects that something had stung her. The patient's blood pressure ... | I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. Th... | Inclusion Criteria:
- Patients <= 12 years of age who have wheezing at the time of study as confirmed by the
physicians' auscultation.
Control:
- Patients <= 12 years of age without history of asthma or other pulmonary conditions,
and who are without wheezing o... | WheezoMeter® Correlation Study | NCT01556958 | Entailment |
1,540 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | INCLUSION CRITERIA:
Controls-Group 1:
Healthy Diagnosis;
21-80 years;
No Cigarette Smoking;
Plasma Cotinine less than 3 ng/mL;
No olanzapine or risperidone
Smoker Patients-Group 2:
Diagnosis of Schizophrenia;
21-50 years;
Cigarett... | Imaging of Brain Receptors in Healthy Volunteers and in Patients With Schizophrenia | NCT00061789 | Contradiction |
2,220 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
Subjects to be included in the study are:
- Outpatients of either gender, age 18 or older
- Diagnosed with symptomatic gout refractory to conventional therapy or unable to
tolerate conventional therapy (for example: having one or more tophi and/or having... | A Study of Persons With Gout Who Do Not Respond to or Are Allergic to Conventional Therapy | NCT00080210 | Contradiction |
4,917 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
1. Men and women age 22 years or older;
2. A diagnosis of ET and PD as confirmed from clinical history and examination by a
neurologist or neurosurgeon specialized in movement disorder;
3. Intolerance to side effects of medication or poor response to med... | Imaging Study of Tremor Disorders | NCT04570046 | Entailment |
66 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Healthy men between the ages of 21- 45 that were recreationally active.
Exclusion Criteria:
- Above 30% body composition, not in the age range, history of asthma, diabetes,
hypoglycemia, or took any hormonal supplements such as testosterone or anabolic... | The Efficacy of Fenugreek Supplementation on Men's Health | NCT03528538 | Contradiction |
921 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Stage I - III osteoarthritis / traumatic arthritis of the thumb.
Exclusion Criteria:
- Exclusion criteria were diabetes mellitus, kidney insufficiency, OA in the STT joint,
or malignancy within the past 10 years.
No condition on gender to be admitted t... | Allograft Meniscal Arthroplasty for the Treatment of Basal Joint Arthritis of the Thumb | NCT01542515 | Entailment |
4,412 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
1. Adult between 18 and 60 years old that is able to speak English.
2. Report of at least 6 weeks of elbow (i.e. lateral epicondyle) and dorsal forearm pain,
consistent with lateral epicondylitis:
3. Patient has not had physical therapy, massage therapy,... | Dry Needling, Manipulation and Stretching vs. Manual Therapy, Exercise and Ultrasound for Lateral Epicondylalgia | NCT03167710 | Contradiction |
4,723 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- They are adult female volunteers, 18 to 45 years of age, who have signed an informed
consent form following a detailed written explanation of participation in the
protocol.
- They are volunteers who are in good health as determined by medical histo... | Reactogenicity and Immunogenicity of Vaginal CNgp140 | NCT00637962 | Entailment |
1,361 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Children 3-7 years old
- Occurrence less than three bowel movement per week
- Medical history from at least two months]
- Ineffective laxative treatment at least two months
- The parents approval for child participation in the study and f... | Lactobacillus Reuteri in Children With Constipation | NCT01388712 | Contradiction |
6,298 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Individuals with a confirmed COVID-19/influenza viral infection, as determined by a
qualified laboratory test. A nasal swab or saliva test analyzed by qPCR for COVID19 or
rapid flu test from nasal swab for influenza.
2. Individuals who agree to abst... | Sodium Pyruvate Nasal Spray Treatment of COVID-19 and Influenza Infections | NCT04824365 | Entailment |
361 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Infertile female or infertile male. Infertile female means diverse infertility
etiologies including tubal disease (excepting hydrosalpinx) and so called "unexplained
infertility"
- Suitable for ART: IVF undergoing first or second attempt, ICSI unde... | EXpression PRofile Endometrium Samples Study | NCT01210144 | Contradiction |
5,071 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Members of the Harvard Pilgrim Health Plan
Exclusion Criteria:
- Individuals who are not members of the Harvard Pilgrim Health Plan
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 64 Years | Comparison of Osteoporosis Disease Management Strategies (0000-039) | NCT00145080 | Contradiction |
2,106 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Completion of informed consent.
- Adults over the age of 18.
- Diagnosis of IPF per ATS guidelines.
- Clinically stable at the time of enrollment defined as no antibiotics within the past
month, with the exception of those patients curre... | Prospective Validation of Cough, Dyspnea, and Quality of Life Questionnaires in Patients With Idiopathic Pulmonary Fibrosis (IPF) | NCT01874223 | Entailment |
143 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. Adult male whose age is between 18 and 80 years, inclusive, at the time of screening.
2. Considered by the investigator to be in good general health as determined by medical
history, clinical laboratory test results, vital sign measurements, 12-lead
... | Vogelxo(R) ABPM Study in Hypogandal Men | NCT04558567 | Contradiction |
1,909 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Can tolerate the cT1~3N0~1M0 phase II type II esophageal gastric junction adenocarcinoma
patients with the corresponding operation, the past or present without radiotherapy,
chemotherapy, nearly 5 years without any other malignant tumor history. According to the
research design, random access to... | Minimally Invasive Sweet Esophagectomy for Patients With Siewert Type II Adenocarcinoma of the Esophagogastric Junction | NCT02741778 | Entailment |
4,582 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Not postmenopausal women aged 30 to 50,
- Accepting to give consent informed in writing,
- Suffering from a symptomatic pelvic endometriosis (menorrhagia isolated or associated
with pain)
- Diagnosis information, confirmed the adenomyosi... | Adenomyosis and Ulipristal Acetate | NCT02587000 | Contradiction |
3,303 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Inclusion Criteria:
- Age of 12 years old and older
- Clinical and/or genetic diagnosis of ocular or oculocutaneous albinism
- Ocular media allowing acceptable visualization of the retina.
- Ocular media allowing acceptable quality of the ocular coherence tomography (OCT)... | The Effects of Lutein and Zeaxanthin Supplementation on Vision in Patients With Albinism | NCT02200263 | Contradiction |
3,896 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- 1) patients of either gender with primary knee OA of one or both knees fulfilling the
diagnostic criteria for knee OA by the American College of Rheumatology,
- 2) Kellgren-Lawrence score of two to four,
- 3) reported NPRS pain intensity of at least... | Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial | NCT04472702 | Entailment |
2,499 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- Aged 55-85
- At least 20/200 corrected visual acuity
- Greater than 20° visual field with no lower visual field loss
- Stable health
- Male or female
- Normal color vision
- Normal hearing
Exclusion Criter... | Light to Maximize Vision, Minimize Insomnia | NCT01712243 | Entailment |
1,833 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Pathologic finding by gastric endoscopy: confirmed gastric adenocarcinoma
- Age: older than 20 year old, younger than 80 year old
- Cancer core: located at the middle or lower part of stomach
- Preoperative cancer stage (CT, GFS stage): cT2N0M0, cT2a... | Comparison of the Laparoscopy-Assisted Distal Gastrectomy and Open Distal Gastrectomy for Advanced Gastric Cancer | NCT00741676 | Entailment |
6,997 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
1. Any patient has a definite diagnosis of AD dementia according to the NIA-AA criteria
for intermediate-to-high levels of biological evidence of probable and possible AD
dementia (McKhann et al. 2011).
2. Dementia onset before age 65 years old.
... | Theta-burst Stimulation on Cognitive Function in the Patients With Young-onset Alzheimer's Disease Dementia | NCT04042532 | Entailment |
2,916 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Patients with diagnosed ALS of any type or duration
- Current or previous treatment with oral riluzole tablets, or patients who have never
taken riluzole oral tablets, or patients who have successfully completed a clinical
trial with BHV-0223 and w... | Expanded Access Protocol of BHV-0223 for Patients With Amyotrophic Lateral Sclerosis (ALS) | NCT03537807 | Entailment |
2,735 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Diagnosis of unilateral inguinal hernia.
- Male or Female.
- Older tan 16 years.
- Accept to participate in the study.
Exclusion Criteria:
- Chronic Obstructive Pulmonary Disease.
- Obesity.
- Diabetes Mel... | Comparison of Postoperative Inguinal Pain Between the Onstep Technique and the Lichtenstein Technique | NCT04138329 | Entailment |
2,593 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
Bilateral congenital inguinal hernia (CIH), recurrent cases, unilateral cases with
questionable other side, parental request and cases with CIH associated with umbilical
hernia.
Exclusion Criteria:
Hernia of canal of Nuck in females, Inguinal hernia with un... | Laparoscopic Inguinal Hernia Repair in Infancy and Childhood | NCT02239185 | Contradiction |
6,629 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Body weight greater than or equal to (>/=) 40 kilograms (kg) at screening
- Diagnosis of severe congenital hemophilia A or hemophilia A with FVIII inhibitors
- Participants using rFVIIa or willing to switch to recombinant activated factor VII
(rFVII... | A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Emicizumab Given Every 4 Weeks in Participants With Hemophilia A | NCT03020160 | Contradiction |
1,046 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Obstructive sleep apnoea syndrome (>15 respiratory micro awakenings per hour of sleep)
with an indication for treatment
- Recurring vasovagal syncope episodes defined as follows: at least three vasovagal
syncopes during the last two years - OR- sym... | Management of Sleep Apnoea Syndrome (SAS) in Patients With Vasovagal Syncope (VVS) | NCT04294524 | Contradiction |
6,083 | 45 | A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is o... | My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor dia... | Inclusion Criteria:
- Trisomy 21
- Able to pull to stand but not walk
Exclusion Criteria:
- Additional developmental diagnoses
- Uncorrected vision or hearing impairments
- Previous orthotic intervention
- Previous treadmill intervention
N... | Treadmill Training and Orthotic Use in Infants With Down Syndrome | NCT00825175 | Contradiction |
3,985 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Key Inclusion Criteria:
- Males and females between 40 and 80 years of age, inclusive, in general good health
apart from their knee OA
- Ambulatory (single assistive devices such as canes allowed if needed less than 50% of
the time, subjects requiring a walker are exclu... | A Study Utilizing Patient-Reported Outcomes to Evaluate the Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis | NCT04385303 | Entailment |
3,106 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
1. Patients must be aged 18 years or older.
2. Patients must have documented moderate to severe evaporative Dry Eye Syndrome for at
least 6 months.
3. Patients must have a Schirmer (with anesthesia) of ≤ 8 per 5 minutes in at least one
eye a... | Civamide Nasal Solution for the Treatment of Dry Eye | NCT02116244 | Contradiction |
1,319 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
1. Presenting clinical features suggestive of a genetic etiology, including intellectual
disability, seizures, multiple congenital anomalies, metabolic conditions, and
neurodegenerative conditions or idiopathic cerebral palsy.
2. A minimum of one biolo... | Clinical Utility of Pediatric Whole Exome Sequencing | NCT03525431 | Contradiction |
6,851 | 49 | A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating. She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems ... | I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not un... | Inclusion Criteria:
- All patients who had a confirmed (muscular biopsy, electromyogram, magnetic resonance
imaging) or suspected clinically myositis. Myositis criteria are as follow:
- Dermatomyositis or polymyositis according to Bohan and Peter criteria (1975)
... | Clinical Database and Biobank of Patients With Inflammatory Myopathies: the MASC Project (Myositis, DNA, Serum, Cells) (MASC) | NCT04637672 | Entailment |
1,236 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
1. Presence of symptomatic and moderate sized (>1/3 of hemithorax) MPE
2. Persistent malignant pleural effusion that is free-flowing
3. Symptomatic improvement after therapeutic thoracentesis
4. Life expectancy of at least three months (duration of study f... | Effectiveness of Doxycycline for Treating Pleural Effusions Related to Cancer in an Outpatient Population | NCT01411202 | Entailment |
5,343 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Subjects must be adult males or females age 18 to 80 years (inclusive).
- Subjects must be able and willing to follow study procedures and instructions in
English.
- Subjects must have read, understood and signed an informed consent form in English.... | A Volumetric Analysis of Soft and Hard Tissue Healing for Ridge Preservation and Socket Seal After Tooth Extraction | NCT02844569 | Contradiction |
1,574 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Overtly healthy males or females, as determined by medical history, physical
examination and vital signs.
- Body mass index (BMI) within the range of 19 to 35 kilograms per meter squared (kg/m²)
- Male participants are not required to adhere to cont... | A Drug Drug Interaction (DDI) Study of Selpercatinib and Dabigatran in Healthy Participants | NCT04782076 | Contradiction |
4,097 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
- Subjects with symptoms of narcolepsy with onset during the period between January 1st,
2009 and December 31, 2010.
Exclusion Criteria:
- Subjects younger than 6 months of age
No condition on gender to be admitted to the trial.
No healthy subjects accep... | Risk of Narcolepsy Associated With Administration of H1N1 Vaccine | NCT01394614 | Entailment |
3,405 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Unilateral ISSNHL with onset within 72 hours prior to study treatment;
2. Mean hearing threshold of equal to or worse than (≥) 60 dB averaged across the 3 most
affected contiguous air conduction audiometric pure tone frequencies ("pure tone
average"... | AM-111 in the Treatment of Acute Inner Ear Hearing Loss | NCT02561091 | Contradiction |
5,928 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Age > 18 years
2. Small hiatus hernia (< 2-3 cm)
3. Los Angeles Grade 'A' or 'B' Reflux Esophagitis or non erosive esophagitis
4. LES pressure <15 mm Hg
5. PPI dependent / refractory GERD
6. abnormal 24h esophagus pH-impedance moni... | the Efficency and Safety of Stretta in GERD | NCT03574831 | Contradiction |
2,440 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- Subject is 18 years of age or older.
- Subject has a diagnosis of cutaneous sarcoidosis for greater than 6 months with a
physician global assessment score of at least 4. Diagnosis (based on the
recommendations of an expert panel 24) can be made by ... | Study to Determine the Efficacy of Adalimumab in the Treatment of Cutaneous Sarcoidosis | NCT00690911 | Entailment |
297 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Age 18 - 50 years, inclusive
- General good health, by volunteer history and per investigator judgment
- History of regular menstrual cycles of 21 - 35 days (inclusive), by volunteer report
- History of a normal PAP smear or ASCUS with negative HPV t... | An Exploratory Study of ZB-06 as a Vaginal Contraceptive Film | NCT04731818 | Contradiction |
4,085 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
- RBD patients:
- Men or women aged 30 to 80
- Patients with idiopathic and secondary RBD (including RBD associated with
Parkinson's disease, Narcolepsy, Multiple System Atrophy or other neurological
diseases) diagnose... | French Validation of a Severity Scale in REM Sleep Behavior Disorder (SEV-TCSP) | NCT04071899 | Entailment |
2,326 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Age 6-16 years - This age range was selected as there are accepted normative pulmonary
function data and children 6 years of age and older are generally able to reliably
perform pulmonary function tests. Children are followed in participating centres until
... | Stacking Exercises Aid the Decline in FVC and Sick Time | NCT01999075 | Entailment |
6,351 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria: Individuals entering into quarantine because of a positive Covid-19
test using either PCR or an authorized antigen assay. It is not necessary, but preferable,
for the participant to be symptomatic for Covid-19 -
Exclusion Criteria: Unwilling to do repeat PCR and/or antigen t... | Inhalation of KELEA Excellerated Water in Covid-19 Infected Individuals | NCT04490824 | Entailment |
6,058 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Patients referred for upper endoscopy for any reason including those with acid reflux,
dyspepsia, weight loss, Barrett's esophagus,suspected Helicobacter pylori infection.
2. Patients able to provide written informed consent.
Exclusion Criteria:
... | Comparison of Acid Reflux at Two Levels in the Esophagus Using the BRAVO Capsule | NCT00579410 | Entailment |
4,586 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Able and willing to provide written informed consent.
2. Agreed to take effective contraceptive measures during and 6 months after the end of
the study period.
3. Age between 18 to 40 years (inclusive).
4. Body weight ≥45 kg, body mass inde... | Single Dose Recombinant Human Follicle Stimulating Hormone Fc Husion Protein (KN015) in Healthy Volunteers | NCT03192527 | Contradiction |
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