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Enalapril and renal injury in spontaneously hypertensive rats. Rats of the spontaneously hypertensive strain develop kidney damage that resembles the nephropathy seen in some cases of human essential hypertension. Previous studies with a triple drug antihypertensive regimen indicated that proteinuria and glomerular his... | cardiovascular diseases |
Brain retractor edema during induced hypotension: the effect of the rate of return of blood pressure. This study evaluated the hypothesis that the postoperative formation of cerebral edema may be influenced by the rate of blood pressure return after induced hypotension in a graded brain retractor injury. Nineteen cats ... | cardiovascular diseases |
Site and strand specificity of UVB mutagenesis in the SUP4-o gene of yeast [published erratum appears in Proc Natl Acad Sci U S A 1991 Mar 1;88(5):2035] DNA sequencing was used to characterize 208 mutations induced in the SUP4-o tRNA gene of the yeast Saccharomyces cerevisiae by UVB (285-320 nm) radiation. The results ... | general pathological conditions |
An effective treatment protocol for intraarterial drug injection. Between 1972 and 1988, 48 patients with extremity ischemia after an intraarterial drug injection were treated with the following protocol: heparin, dextran 40, dexamethasone, elevation, and early mobilization of the extremity. A tissue ischemia score, de... | general pathological conditions |
Immunohistochemical demonstration of keratin in ameloblastoma as an indication of tumor differentiation. Keratin expression was studied immunohistochemically in 27 ameloblastomas using polyclonal antibody against wide-spectrum keratins (TTL) and monoclonal antibodies against lower- and higher-molecular-weight keratins ... | general pathological conditions |
Doppler assessment of pulmonary artery pressure and extrapulmonary shunting in the acute phase of hyaline membrane disease. The natural history of pulmonary artery pressure and extrapulmonary shunting in acute hyaline membrane disease was studied by serial Doppler echocardiography in 57 preterm infants, 38 with, and 19... | general pathological conditions |
Extrapyramidal features in advanced Down's syndrome: clinical evaluation and family history. Extrapyramidal, frontal release, and other neurological signs were studied in 54 demented and non-demented patients with Down's syndrome (DS). Fourteen patients were demented and five showed extrapyramidal signs, mainly of the ... | nervous system diseases |
Resuscitation of patients with cardiac arrest by ambulance staff with extended training in West Yorkshire OBJECTIVE--To investigate the results of resuscitation of patients with cardiac arrest by ambulance staff with extended training in West Yorkshire. DESIGN--Study of all such attempts at resuscitation over 32 months... | cardiovascular diseases |
Inadvertent clavicular fractures caused by "chiropractic" manipulations in an infant: an unusual form of pseudoabuse. A nine-month-old child was found unresponsive in his crib, five hours after his last feeding. At autopsy, there were no external or internal signs of abuse or neglect, and a few visceral pleural and epi... | general pathological conditions |
Monomorphic adenomas of the major salivary glands: clinicopathological study of 44 cases. We report 44 cases of monomorphic adenoma (MA) of the major salivary glands observed during the years 1979-1989. All of these tumours were reviewed and classified on the basis of the World Health Organisation (WHO) criteria. Histo... | neoplasms |
Hilger facial nerve stimulator: a 25-year update. Percutaneous nerve excitability testing using the Hilger facial nerve stimulator was introduced about 25 years ago. The test is reliable, easy to use, and inexpensive; it continues to be the most frequently used method for predicting prognosis of facial nerve disorders.... | general pathological conditions |
Cryoprobe as a "handle" for resection of metastatic liver tumors. Resection of metastatic liver tumors can be a difficult and risky procedure. Using a cryoprobe as a "handle" can greatly facilitate resection by providing a taut surface for transection and improving visualization of ductal and vascular structures. In ad... | neoplasms |
Cardiac arrest during hip arthroplasty with a cemented long-stem component. A report of seven cases. Seven patients had a cardiac arrest during hip arthroplasty with a cemented long-stem femoral component. Four patients died in the operating room, and three patients were successfully resuscitated. When the three surviv... | general pathological conditions |
Incorporation of 12-methoxydodecanoate into the human immunodeficiency virus 1 gag polyprotein precursor inhibits its proteolytic processing and virus production in a chronically infected human lymphoid cell line. Covalent linkage of myristate (tetradecanoate; 14:0) to the NH2-terminal glycine residue of the human immu... | neoplasms |
Factors affecting survival in total artificial heart recipients before transplantation. To identify factors affecting the successful bridge to transplantation, experience with 32 recipients of the Jarvik-7 artificial heart was reviewed. Between patients with and without a successful bridge, there were no significant di... | cardiovascular diseases |
Results of conservative surgery and radiation therapy for breast cancer. For stage I or II breast cancer, conservative surgery and radiation therapy are as effective as modified radical or radical mastectomy. In most cases, cosmetic considerations and the availability of therapy are the primary concerns. The extent of ... | neoplasms |
Comparison of two doses of endotracheal epinephrine in a cardiac arrest model. STUDY OBJECTIVE: The objective of this study was to measure plasma catecholamine levels and the cardiovascular response before and after endotracheal administration of epinephrine in a swine cardiac arrest model. DESIGN: Prospective, control... | cardiovascular diseases |
SPECT imaging of pediatric brain tumor with hexakis (methoxyisobutylisonitrile) technetium (I). Technetium-99m-Hexamibi [Hexakis (methoxyisobutylisonitrile) technetium (i)] was developed as a myocardial perfusion agent with biologic properties similar to those of thallium-201 (201TI). As 201TI has recently been observe... | neoplasms |
Time course of hemodynamic responses to sodium in elderly hypertensive patients. Thirty-one patients with essential hypertension (81.6 +/- 6.9 years old) were studied during two different regimens of sodium intake: 120 meq/day for 8 weeks and 344 meq/day for 2 weeks. Systemic hemodynamic data were measured with Doppler... | cardiovascular diseases |
Intraperitoneal femoral venous catheter insertion with free blood return in presence of tense hemoperitoneum. The authors report a case of intraperitoneal insertion of a femoral venous catheter, with blood return, in a patient with hemoperitoneum. In such patients, skin puncture at or below the inguinal ligament is imp... | digestive system diseases |
Mutation of the prion protein in Libyan Jews with Creutzfeldt-Jakob disease. BACKGROUND. Creutzfeldt-Jakob disease is a transmissible neurodegenerative disorder that occurs more than 100 times more frequently among Libyan Jews than in the worldwide population. We examined 11 patients with the disease--10 Libyan Jews fr... | nervous system diseases |
Interphase cytogenetic analysis in the diagnosis and study of neoplastic disorders. Cytogenetic information usually is obtained through the direct analysis of chromosomes from cells arrested in metaphase. Recently, advances in molecular genetics have made it possible to acquire cytogenetic information through the study... | general pathological conditions |
Tumor cell heterogeneity and subpopulations with metastatic ability in differentiated adenocarcinoma of the lung. Histologic and cytofluorometric DNA analyses. To investigate tumor cell heterogeneity and subpopulations with metastatic ability in differentiated adenocarcinoma of the lung, the primary and metastatic lesi... | neoplasms |
The influence of neutralizing heparin after carotid endarterectomy on postoperative stroke and wound hematoma. The influence of neutralizing or not neutralizing heparin after carotid endarterectomy on postoperative stroke and wound hematoma is unknown. During the past 6 years some of the authors frequently gave protami... | general pathological conditions |
Leiomyoma of a digital artery. Benign, soft-tissue masses of the hand are common. A vascular leiomyoma is an unusual tumor of smooth-muscle origin. In a 62-year-old man, the tumor arose from within a digital artery. Persistent symptoms prompted an excisional biopsy, requiring resection of a portion of the artery. Adequ... | neoplasms |
Quantitative analysis of antibody localization in human metastatic colon cancer: a phase I study of monoclonal antibody A33. A33 is a mouse immunoglobulin G2a (IgG2a) monoclonal antibody (mAb) that detects a heat-stable, protease- and neuraminidase-resistant epitope. The antigen is homogeneously expressed by virtually ... | neoplasms |
Continuing care for cancer pain relief with oral morphine solution. One-year experience in a regional cancer center. This report is a prospective study of 223 patients with intractable cancer pain who were offered continuing care during the year 1988 at the Pain Relief Unit, Kidwai Memorial Institute of Oncology, Banga... | general pathological conditions |
Amiloride blocks the onset of ACTH-induced hypertension in the sheep. This study investigated the ability of two diuretics, amiloride and frusemide, to prevent the development of ACTH induced hypertension in conscious sheep. Infusion of amiloride (20 mg/day) or frusemide (50 mg/day) for three days into normotensive she... | cardiovascular diseases |
5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease. Interleukin 1 beta in biopsy specimens from inflamed colonic mucosa of patients with active inflammatory bowel disease was studied. Compared with norma... | digestive system diseases |
Histocompatibility testing in transplantation. The question of whether or not HLA is important in transplantation can now be answered with a definite yes. The nationwide six-antigen-matching program, in which over 100 US transplantation centers have participated, has shown that a high (88% to 90%) 1-year graft survival... | general pathological conditions |
Bleeding complications associated with cardiopulmonary bypass. Bleeding after CPB has been difficult to characterize and its treatment equally difficult to standardize. The complexity of this problem is related to the hemostatic process, the technical variations in the operative procedures, and the many uncontrolled va... | general pathological conditions |
Interphase cytogenetic analysis detects minimal residual disease in a case of acute lymphoblastic leukemia and resolves the question of origin of relapse after allogeneic bone marrow transplantation. We used in situ hybridization with a probe for the X chromosome to study interphase cells of bone marrow and peripheral ... | neoplasms |
Retroperitoneal air after routine hemorrhoidectomy. Report of a case. Retroperitoneal air as a complication after routine hemorrhoidectomy has not been reported in the literature. This occurred recently after hemorrhoidectomy in a 34-year-old patient receiving glucocorticoid therapy for rheumatoid arthritis. Adverse st... | cardiovascular diseases |
Late results with Carpentier-Edwards porcine bioprosthesis. From 1977 to 1984, 429 patients underwent aortic valve replacement (AVR), and 339 underwent mitral valve replacement (MVR) with a Carpentier-Edwards bioprosthesis. Early mortality for AVR was 4.6% (isolated AVR, 1.9%) and for MVR was 5.3% (isolated MVR, 4.1%).... | general pathological conditions |
Acute changes in the dynamics of the cerebrospinal fluid system during experimental subarachnoid hemorrhage. Early changes in intracranial pressure (ICP), ICP volume index, and resistance to absorption of cerebrospinal fluid induced by experimental subarachnoid hemorrhage were studied in cats. After SAH, the ICP was sl... | cardiovascular diseases |
Changes in high-energy phosphate metabolism and cell morphology in four models of acute experimental pancreatitis. Previous studies using the isolated ex vivo perfused canine pancreatitis preparation showed that during a 4-hour perfusion pancreatitis (edema, weight gain, hyperamylasemia) can be induced by four differen... | general pathological conditions |
Evolution of deep venous thrombosis: a prospective evaluation with US. Forty-six patients with a diagnosis of acute deep venous thrombosis (DVT) established by means of duplex ultrasound (US) were prospectively followed up with serial duplex US examinations during a 6-month period to assess the persistence of venous ab... | cardiovascular diseases |
Right parietal stroke with Gerstmann's syndrome. Appearance on computed tomography, magnetic resonance imaging, and single-photon emission computed tomography. We examined a patient who exhibited Gerstmann's syndrome (left-right disorientation, finger agnosia, dyscalculia, and dysgraphia) in association with a perioper... | nervous system diseases |
Irritable bowel syndrome in women having diagnostic laparoscopy or hysterectomy. Relation to gynecologic features and outcome. We identified irritable bowel syndrome (IBS) in 47.7% of 86 women having diagnostic laparoscopy for chronic pelvic pain, 39.5% of 172 women having elective hysterectomy, and 32.0% of 172 contro... | digestive system diseases |
Effect of ischemia reperfusion or hypoxia reoxygenation on lung vascular permeability and resistance. The effect of ischemia reperfusion or hypoxia reoxygenation on pulmonary vascular permeability and resistance was studied in 25 isolated blood-perfused dog lungs. Vascular permeability, assessed by determining filtrati... | general pathological conditions |
Importance of hemodynamic response to therapy in predicting survival with ejection fraction less than or equal to 20% secondary to ischemic or nonischemic dilated cardiomyopathy. To identify patients with left ventricular ejection fractions less than 20% who are likely to survive on tailored medical therapy after refer... | cardiovascular diseases |
Medical treatment and prevention of peptic ulcer disease. Many agents seem to be equally effective for the treatment of peptic ulcer disease. This is true despite the drugs' varied mechanisms of action, and this observation has caused investigators to shift their focus from aggressive to defensive factors when studying... | digestive system diseases |
Idiopathic hypereosinophilic syndrome terminating as disseminated T-cell lymphoma. The authors describe a case of idiopathic hypereosinophilic syndrome (HES) terminated as a T-cell lymphoma in a 3-year-old girl. The clinical course was chronic and characterized by chronic eczema, persistent peripheral blood eosinophili... | cardiovascular diseases |
Macrophages as susceptible targets for HIV infection, persistent viral reservoirs in tissue, and key immunoregulatory cells that control levels of virus replication and extent of disease. Although macrophages are major targets for human immunodeficiency virus (HIV) infection in vivo, study of HIV-macrophage interaction... | general pathological conditions |
Congenital chyloperitoneum as a cause of isolated fetal ascites. Isolated fetal ascites is an unusual prenatal finding and must be differentiated from immune and nonimmune hydrops. This entity is most commonly associated with gastrointestinal and genitourinary anomalies. Fetal chyloperitoneum, however, should be consid... | digestive system diseases |
Fetal platelet counts in thrombocytopenic pregnancy Fetal platelet counts were assessed by percutaneous umbilical blood sampling in 64 pregnancies (62 women) with maternal thrombocytopenia. In 33 pregnancies associated with chronic immune thrombocytopenia, 11 of the fetuses had platelet counts below 150 x 10(9)/l and 4... | general pathological conditions |
Pharmacokinetics of indium-111-labeled antimyosin monoclonal antibody in murine experimental viral myocarditis. The pharmacokinetics of indium-111-labeled antimyosin monoclonal antibody Fab were investigated with use of murine experimental viral myocarditis as a model. The biodistribution of indium-111-labeled antimyos... | cardiovascular diseases |
Intrathoracic Nissen fundoplication: long-term clinical and pH-monitoring evaluation. From 1976 until April 1989, 31 intrathoracic total fundoplications were performed for reflux esophagitis and irreducible hiatus hernia. In the first 16 patients (group 1) the operation was complicated with acute perforation of the wra... | general pathological conditions |
Basic mechanisms in vascular headache. To better understand and treat painful conditions, one needs to identify the cause, discover the source, and develop knowledge of peripheral and central pain transmission; headaches are no exception. The development of appropriate animal models is important. Accordingly, we have r... | nervous system diseases |
Third-trimester fetal death in triplet pregnancies. During the last decade, 89 sets of triplets were born in Denmark with a gestational age of more than 25 completed weeks. Fifteen pregnancies (16.9%) were complicated by fetal death in the third trimester, with a total of 17 intrauterine deaths. Six neonatal deaths occ... | general pathological conditions |
Humeral head retroversion in patients with unstable humeroscapular joints. Humeral head retroversion and shoulder rotation in both the frontal and scapular plane were studied in 34 patients with anterior glenohumeral instability. Twenty-two patients had traumatic anterior shoulder dislocations and another 12 patients h... | general pathological conditions |
High ethanol consumption as risk factor for intracerebral hemorrhage in young and middle-aged people. We examined the prevalence of high ethanol intake, hypertension, and other risk factors for intracerebral hemorrhage in a case-control study of 24 young and middle-aged patients with intracerebral hemorrhage. We record... | general pathological conditions |
Percutaneous aspiration of brain tumor cysts via the Ommaya reservoir system. We performed percutaneous aspiration of 21 brain tumor cysts in 20 patients using the Ommaya reservoir system. Ages ranged from 3 to 70 years, median 48. Sixteen were primary tumors (12 anaplastic glioma, 2 craniopharyngioma, 1 oligodendrogli... | neoplasms |
Compressive neuropathy of spinal nerve roots. A mechanical or biological problem? Pathophysiologically, nerve root pain production is a complex issue. For many years, mechanical compression has been regarded as the sole cause for such pain. There are indications, however, that other factors, such as intraneural inflamm... | general pathological conditions |
Gastroesophageal reflux disease: an update on management. Gastroesophageal reflux is commonplace; all humans experience it. For many patients, gastroesophageal reflux disease (GERD) is a manageable condition. For others, GERD can progress to severe symptoms, inflammation, and disruption of the mucosal lining. Effective... | digestive system diseases |
Vesicular changes in the myopathies of AIDS. Ultrastructural observations and their relationship to zidovudine treatment. Six patients with AIDS and AIDS related complex (ARC) who developed neuromuscular symptoms associated with vesicular changes in muscle fibres are reported. Two patients in the advanced stages of AID... | nervous system diseases |
The cytobrush for evaluating routine cervicovaginal-endocervical smears. While the conventional wooden spatula/cotton-tipped applicator has remained the method of obtaining Papanicolaou smears for most clinicians at the University of California at Los Angeles, the Student Health Service (SHS) adopted the Zelsmyr cytobr... | neoplasms |
Radiation-induced proctosigmoiditis. Prospective, randomized, double-blind controlled trial of oral sulfasalazine plus rectal steroids versus rectal sucralfate. In a prospective study, 37 consecutive patients with radiation-induced proctosigmoiditis were randomized to receive a four-week course of either 3.0 g oral sul... | digestive system diseases |
Imaging of adult central nervous system primary malignant gliomas. Staging and follow-up. A classification and staging system for primary adult gliomas was proposed. This system uses the high signal intensity found on proton density or T2-weighted magnetic resonance (MR) scans at the site of the tumor and surrounding e... | neoplasms |
The surgical treatment of ingrowing toenails. Two prospective studies of ingrowing toenail management were conducted. In the first, 163 patients (204 ingrowing nail edges) who had not had previous surgery were randomised and treated by total nail avulsion, nail edge excision, or nail edge excision with phenolisation of... | general pathological conditions |
Transoesophageal pacing for perioperative control of neonatal paroxysmal supraventricular tachycardia. The perioperative management of a 16-day-old infant with recurrent supraventricular tachycardia (SVT) is discussed. Vagal manoeuvres and medication were not adequate in controlling the SVT. Since the patient was sched... | general pathological conditions |
Clinical and positron emission tomographic studies in the 'extrapyramidal syndrome' of dementia of the Alzheimer type. Extrapyramidal signs, particularly rigidity and tremor, have been reported in a proportion of patients with dementia of the Alzheimer type. To test the hypothesis that these extrapyramidal signs are si... | nervous system diseases |
Excretion of thromboxane A2 and prostacyclin metabolites before and after exercise testing in patients with and without signs of ischemic heart disease. We addressed the hypothesis that platelets are not activated in association with effort-induced myocardial ischemia in stable coronary disease. Seventy-two patients un... | cardiovascular diseases |
Intraoperative management of severe endobronchial hemorrhage Endobronchial hemorrhage due to pulmonary artery perforation by a Swan-Ganz catheter developed during coronary artery bypass grafting while weaning from cardiopulmonary bypass. After reinstitution of cardio-pulmonary bypass with pulmonary artery venting, blee... | general pathological conditions |
Entrapment of a folded-over introducer sheath in the iliofemoral artery: an unusual complication of PTCA guiding catheter exchange An arterial introducer sheath became folded over in the iliac artery during PTCA. This probably resulted from withdrawal of a doubled over Judkins left coronary guiding catheter through the... | general pathological conditions |
Restricted heterogeneity of T lymphocytes in combined immunodeficiency with hypereosinophilia (Omenn's syndrome). We report the immunological characteristics of five patients with Omenn's syndrome, a rare inherited immunodeficiency also known as combined immunodeficiency with hypereosinophilia. The syndrome is characte... | general pathological conditions |
Methodological problems in evaluation of cardiovascular effects of stress in humans. Cardiovascular effects of stress in humans are often assessed by application of physical or emotional stimuli in a laboratory environment. Although this method provides important information, these procedures have several limitations. ... | general pathological conditions |
Biohistory of slavery and blood pressure differences in blacks today. A hypothesis. Genetic factors are known to play an important role in the variations in blood pressure levels. However, genetic factors that explain the higher average blood pressure levels of western hemisphere blacks when compared with African black... | cardiovascular diseases |
Intrapalatine resection (IPR) in the treatment of sleep apnea and snoring. A conservative surgical technique is proposed as an alternative to the classical uvulopalatopharyngoplasty (UPPP) for the treatment of obstructive sleep apnea and snoring. The resection is strictly intrapalatine, and careful suturing in three pl... | general pathological conditions |
Longitudinal histopathologic assessment of rejection after bladder-drained canine pancreas allograft transplantation. In preparation for assessment of percutaneous biopsies in our clinical pancreas transplant program, a working knowledge of the histopathologic changes after transplantation was obtained in a longitudina... | general pathological conditions |
Anemia after traumatic spinal cord injury. The incidence and natural history of anemia in patients with spinal cord injuries (SCI) were investigated in a prospective study of 68 patients consecutively admitted to a regional acute SCI unit. Fifty had SCI and 18 had spine injuries (SI) without neurologic deficit. Thirty-... | nervous system diseases |
Ontogenetic features of audiogenic seizure susceptibility induced in immature rats by noise. Although numerous models are currently used for systematic study of the mechanisms of epileptogenesis in mature brain, few animal models have been developed that allow similar explorations in the developing nervous system. One ... | general pathological conditions |
Chylous ascites should suggest constrictive pericarditis even in a patient with cirrhosis. Chylous ascites, a milky, high triglyceride fluid is usually found in patients with lymphatic obstruction from malignancy. We describe a patient with cirrhosis who developed constrictive pericarditis and chylous ascites. Long-sta... | digestive system diseases |
Full recovery after a chloroquine suicide attempt. The nonfatal case of a 20 year-old woman who ingested 6 grams of chloroquine in a suicide attempt is reported. After initial ventricular fibrillation, she rapidly developed a pulmonary edema with cardiogenic shock. She was successfully treated with diazepam, epinephrin... | general pathological conditions |
Heterotopic liver transplantation for fulminant Wilson's disease. Wilson's disease may present with severe acute hepatocellular failure. The only effective treatment for fulminant Wilson's disease is liver transplantation, which may lead to reversal of the underlying disease. Some patients with cirrhosis who are too il... | nervous system diseases |
Effect of antiarrhythmic therapy on mortality in survivors of myocardial infarction with asymptomatic complex ventricular arrhythmias: Basel Antiarrhythmic Study of Infarct Survival (BASIS) In view of the high risk of sudden cardiac death and the prognostic importance of complex ventricular ectopic activity, the effect... | general pathological conditions |
Putative mechanisms of cytoprotective effect of certain antacids and sucralfate. An investigation of cytoprotective activity of certain antacids and inert particles was carried out by treating ethanol-induced gastric mucosal damage in rats in order to clarify possible mechanisms by which aluminum-containing antacids ac... | digestive system diseases |
Transesophageal echocardiography is superior to transthoracic echocardiography in the diagnosis of sinus venosus atrial septal defect. The purpose of this study was to compare transthoracic and transesophageal echocardiography in the diagnosis of various types of atrial septal defects. Forty-one adult patients with the... | cardiovascular diseases |
Noninvasive assessment of cerebral collateral blood supply through the ophthalmic artery. We assessed the potential of 2-MHz pulsed-wave transorbital Doppler ultrasonography to delineate the role of the ophthalmic artery as a source of collateral cerebral blood supply by comparing oculopneumoplethysmography, transorbit... | cardiovascular diseases |
Retroperitoneal mobilization of the vas deferens in the complex vasovasostomy. Anatomic distances along retroperitoneal, inguinal, and infrainguinal segments of the vas deferens were measured in 14 formalin fixed cadavers and in 15 recently postmortem males. There were no significant differences in segment lengths betw... | general pathological conditions |
Sequential magnetic resonance imaging following stereotactic radiofrequency ventralis lateralis thalamotomy. Serial postoperative magnetic resonance (MR) studies were obtained in 21 patients who underwent somatotopically placed stereotactic radiofrequency (rf) ventralis lateralis thalamotomy for the control of movement... | general pathological conditions |
Prehospital care: the future of emergency medical services. Most prehospital interventions, both pharmacologic and procedural, have been accepted without clear demonstrations of their abilities to impact patient outcomes or without clear indications that withholding or delaying the intervention pending arrival at a def... | general pathological conditions |
Myocardial infarct size-limiting effect of ischemic preconditioning was not attenuated by oxygen free-radical scavengers in the rabbit. BACKGROUND. The limiting effect of ischemic preconditioning on infarct size has been reported in canine hearts, which contain considerable amounts of xanthine oxidase, a free radical-p... | cardiovascular diseases |
Decreased toxicity of polymorphonuclear neutrophils toward hepatocytes isolated from rats with acute inflammatory reaction. We have recently demonstrated that polymorphonuclear neutrophils were toxic to hepatocytes through a protease-mediated mechanism. Since synthesis of antiproteases is markedly increased during acut... | digestive system diseases |
Photodynamic therapy in the treatment of squamous cell carcinoma of the head and neck. Photodynamic therapy is an experimental modality for tumor treatment based on the combined action of the tumor-localizing agent, ie, hematoporphyrin derivative, and red light. From 1985 through 1989, 26 patients were treated using he... | neoplasms |
Cystic fibrosis mutations in North American populations of French ancestry: analysis of Quebec French-Canadian and Louisiana Acadian families. A 3-bp deletion (delta F508) in the cystic fibrosis (CF) gene is the mutation on the majority of CF chromosomes. We studied 112 CF families from North American populations of Fr... | general pathological conditions |
Influence of bronchial arterial PO2 on pulmonary vascular resistance. In six anesthetized and mechanically ventilated adult sheep, the bronchial artery was perfused with blood from an oxygenator-pump circuit. When the lungs were ventilated with 100% O2 and the bronchial O2 tension (PbrO2) was approximately 600 Torr, th... | general pathological conditions |
Relation between intraventricular pressure and volume in diastole. The pressure-volume curves for 10 patients with various types of heart disease were studied throughout mid to late diastole when both pressure and volume were increasing. The results were used to test a currently held theory that the form of this relati... | cardiovascular diseases |
Roles of beta 1- and beta 2-adrenoceptors in the mechanism of halothane myocardial sensitization in dogs. The authors investigated the comparative roles of beta 1- and beta 2-adrenoceptors in myocardial sensitization by halothane in dogs. The arrhythmogenic dose (AD) of isoproterenol was determined in the presence of v... | general pathological conditions |
Gastrointestinal pathology in adult iron overdose. The gastrointestinal effects of iron overdose have been described in children. They may occur acutely, ranging in severity from mucosal injury to complete infarction, or several weeks later, as obstruction due to stricture formation. They typically occur in the stomach... | digestive system diseases |
Chronic pain in primary care. Identification and management of psychosocial factors. Chronic pain is a problem of great public health importance that is frequently seen in the primary care setting. Pain chronicity shows a strong association with psychosocial factors. Assessment of these factors should be composed of tw... | nervous system diseases |
Valve replacement in patients with endocarditis and cerebral septic emboli. Cerebral septic emboli complicate the cases in 20% to 40% of patients with left-sided endocarditis but the management of these patients who require a valvar operation remains unclear. From 1980 to 1988, the incidence of cerebral septic embolus ... | general pathological conditions |
Multivessel coronary angioplasty from 1980 to 1989: procedural results and long-term outcome From June 1980 to January 1989, 3,186 patients had coronary angioplasty of two (2,399 patients) or three (787 patients) of the three major epicardial coronary systems. A mean of 3.6 lesions (range 2 to 14) were dilated per pati... | cardiovascular diseases |
Extramedullary hematopoiesis in a bronchial carcinoid tumor. An unusual complication of agnogenic myeloid metaplasia. A case of bronchial carcinoid tumor with foci of extramedullary hematopoiesis is presented. The patient had a 6-year history of agnogenic myeloid metaplasia and hepatosplenomegaly. All three hematopoiet... | neoplasms |
Multi-institutional evaluation of the Tokyo University Ventricular Assist System. A total of 61 VASs developed in Tokyo University were evaluated at 21 institutions in the period 1985-1989 for determination of its reliability and effectiveness. The system is comprised of a pneumatic sack-type pump (Nippon Zeon Co.), an... | general pathological conditions |
Chondrosarcoma complicating total hip arthroplasty in Maffucci's syndrome. A 70-year-old woman who was followed for 60 years for Maffucci's syndrome required a total hip arthroplasty (THA) of the right hip for degenerative arthritis. This did not relieve pain. Three years later, chondrosarcoma of the femur developed ar... | neoplasms |
Effects of antihypertensive therapy on mechanics of cerebral arterioles in rats. The purpose of this study was to examine effects of antihypertensive treatment on structure and mechanics of cerebral arterioles and the incidence of stroke in stroke-prone spontaneously hypertensive rats (SHRSP). Treatment of hypertension... | cardiovascular diseases |
Rapid diagnosis of lung cancer from palpable metastases by needle thrust. This study encourages the use of percutaneous FNB to diagnose and stage advanced lung cancer in patients with palpable metastases in supraclavicular lymph nodes or soft tissues. Percutaneous FNB of metastases is much easier to learn than transtho... | neoplasms |
Electrocardiographic ambulatory monitoring with a real-time analysis system. The analysis of records collected during long-term ambulatory electrocardiographic monitoring has traditionally involved the review of massive data, either manually or with the aid of interactive scanning computers. Many factors complicate thi... | general pathological conditions |
Long-term vascular access via the inferior vena cava. A prospective evaluation of long-term venous access catheters placed via the inferior vena cava was performed to determine their efficacy as well as short- and long-term morbidity. From June 1987 to May 1989, 31 catheters were placed in 26 patients, for a total of 3... | neoplasms |
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