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Left ventricular hypertrophy in elderly hypertensive patients: a report from the European Working Party on High Blood Pressure in the Elderly trial. In a double-blind, placebo-controlled trial, 840 elderly hypertensive patients were randomly assigned to treatment with a combination of hydrochlorothiazide and triamteren... | cardiovascular diseases |
Fetal and maternal response to intravenous infusion of a thromboxane synthetase inhibitor. Pharmacologic inhibition of thromboxane synthetase activity has reversed the clinical manifestations of toxemia in the ovine model. To investigate placental transfer and fetal effects of a selective thromboxane synthetase inhibit... | cardiovascular diseases |
Parathyroid hormone secretion and target organ response in experimental acute pancreatitis. To determine changes in parathyroid hormone secretion and target organ response caused by acute pancreatitis before the development of systemic toxic conditions, experimental acute pancreatitis was induced in rats with a choline... | general pathological conditions |
Neurologic complications in chronic renal failure: a retrospective study. We have retrospectively examined 324 patients with chronic renal failure and evaluated the probable underlying causes of neurologic complications, laboratory data and therapeutic interventions. The common neurologic problems in our patients were ... | nervous system diseases |
Postischemic (S)-emopamil therapy ameliorates focal ischemic brain injury in rats. (S)-Emopamil is a calcium channel blocker of the phenylalkylamine class, having potent serotonin S2 antagonistic properties and high blood-brain barrier penetrability. Previous studies have documented cerebroprotective effect in animal m... | nervous system diseases |
Transient renal acidification defect during acute infantile diarrhea: the role of urinary sodium. We studied urinary acidification daily during the hospital course of 16 infants with acute gastroenteritis and metabolic acidosis. Urine pH value on admission was higher than 5.5 in 14 (87%) patients. We hypothesized that ... | digestive system diseases |
Future directions for etoposide therapy. Etoposide is an important chemotherapeutic agent in the treatment of selected patients with germ cell tumors, lymphomas, and small cell lung cancer (SCLC). Its optimal use is continuing to evolve. It is clear that schedule dependency is of critical importance. Recently, prelimin... | neoplasms |
Intestinal pseudoobstruction secondary to amyloidosis responsive to cisapride. A case of chronic intestinal pseudoobstruction secondary to systemic amyloidosis in a patient with multiple myeloma is described. Gastrointestinal symptoms and indices of nutrition improved markedly after commencing treatment with cisapride,... | digestive system diseases |
Nephrotoxicity of allopurinol is enhanced in experimental hypertension. Hyperuricemia is present in 20-40% of pediatric and adult patients with essential hypertension. This metabolic abnormality may represent an additional risk factor for the development of cardiovascular disease. Therefore, we performed the following ... | cardiovascular diseases |
Managing prostatitis in the elderly. Bacterial prostatitis is primarily a disease of elderly men, and it is the most common urinary tract infection seen in this age group. Urosepsis from prostatitis or prostatic abscess occurs less frequently than with urological manipulation, but must always be considered in elderly m... | general pathological conditions |
Acute complications of percutaneous transluminal coronary angioplasty for total occlusion. The incidence of major complications after percutaneous coronary angioplasty (PTCA) of a totally occluded artery was assessed retrospectively. A total of 1649 PTCA procedures were analyzed. After exclusion of procedures for acute... | cardiovascular diseases |
Renal effects of cyclosporine. Renal dysfunction is a frequent consequence of cyclosporine administration, even when cyclosporine blood concentrations are maintained within proper therapeutic levels. As dermatologic indications for this compound expand, it is important for clinicians to understand the relevant pharmaco... | cardiovascular diseases |
Antiepileptic medication in pregnancy: late effects on the children's central nervous system development. In a follow-up study long-term effects of antenatal exposure to two anticonvulsant drugs, phenobarbital and carbamazepine on central nervous system development were evaluated. Children aged 6 to 13 years of epilept... | nervous system diseases |
Symptomatic pineal cyst: case report. Pineal cysts are being described with increasing frequency since the advent of magnetic resonance imaging. Although pineal cysts are incidental findings in as many as 4% of magnetic resonance imaging studies, symptomatic pineal cysts are quite rare. We present a case of pineal cyst... | nervous system diseases |
Immune-competent cells of regional lymph nodes in colorectal cancer patients: II. Immunohistochemical analysis of Leu-7+ cells. Distribution of Leu-7+ cells in cancer tissues and regional lymph nodes was immunohistochemically examined to estimate the role of NK cells in colorectal cancer patients. Leu-7+ cells were rar... | neoplasms |
Dissection of the aorta and dissecting aortic aneurysms. Improving early and long-term surgical results. We report the improving surgical results in a consecutive series of 690 patients referred to one of us (E.S.C.) for aortic dissection between December 1956 and September 1989, a substantial portion of whom had disse... | cardiovascular diseases |
Chronic illness and depressive symptoms in the elderly: a population-based study. A cross-sectional study of the distribution of depressive symptoms and association between depressed mood and chronic illness was conducted in a geographically defined population in southern California of 1617 men and women aged 65 years ... | general pathological conditions |
Intermittent obstruction of an incarcerated hiatal hernia with a total thoracic stomach. A case of intermittent obstruction of a sliding hiatal hernia is presented. The obstruction occurred when the patient's stomach was totally above the diaphragm. The anatomy of sliding hiatal hernias is discussed, as well as the pre... | digestive system diseases |
A multifaced DNA ploidy analysis to determine ovarian carcinoma aggressiveness. A microfluorometric DNA study was conducted on isolated cells from 64 fragments of ovarian epithelial tumors. Data analysis considered the DNA content of the main stemline and the prevalence of cells in the different compartments of the DNA... | neoplasms |
Cranial nerve palsy in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma. Forty-five children with acute lymphoblastic leukemia or non-Hodgkin's lymphoma had cranial nerve palsy (CNP) as a complication of their disease. Twenty-two of these children had CNP initially and 23, at relapse, with or without p... | nervous system diseases |
Clinical experience with the Medtronic-Hall valve prosthesis. Medtronic-Hall valves were implanted during 204 procedures performed between 1982 and 1988. Mean population age was 54.4 years; 96% of patients were in New York Heart Association functional class III or greater. Emergency operations constituted 16% of the pr... | cardiovascular diseases |
Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease. Severe methylenetetrahydrofolate reductase (MTHFR) deficiency with less than 2% of normal enzyme activity is characterized by neurological abnormalities, atherosclerotic changes, and thromboembolism. We have discover... | cardiovascular diseases |
Central corpectomy for cervical spondylotic myelopathy: a consecutive series with long-term follow-up evaluation. Since 1984, a consecutive series of patients with cervical spondylotic myelopathy has been treated by central corpectomy and strut grafting. This report focuses on 40 cases operated on between 1984 and 1987... | general pathological conditions |
Impact of a public cholesterol screening program. The National Cholesterol Education Program (NCEP) has endorsed physician case finding as the primary method to detect individuals with elevated cholesterol levels. Despite this recommendation, promotional and for-profit public screening programs have flourished. We surv... | cardiovascular diseases |
Differential alpha-fetoprotein lectin binding in hepatocellular carcinoma. Diagnostic utility at low serum levels. The reactivity of serum alpha-fetoprotein (AFP) from 20 patients with hepatocellular carcinoma (HCC) with immobilized lentil lectin was examined and found to be significantly greater (39% +/- 18%) than tha... | general pathological conditions |
Clinicopathologic characteristics of adenosquamous carcinoma of the lung. Fifty-six cases of surgically resected adenosquamous carcinoma of the lung were studied clinicopathologically, and their outcome was compared with that of adenocarcinomas and squamous cell carcinomas of the lung. The frequency rate of adenosquamo... | neoplasms |
The fat embolism syndrome. A review. While fat embolism occurs in most (more than 90%) patients with traumatic injury, the fat embolism syndrome (FES) occurs in only 3%-4% of patients with long-bone fractures. FES involves multiple organ systems and can cause a devastating clinical deterioration within hours. The major... | cardiovascular diseases |
Warner-Lambert/Parke-Davis Award lecture. Pathobiology of the intestinal epithelial barrier. The major route of passive permeation across intestinal epithelia is paracellular. The intercellular tight junction lies in and serves as the rate-limiting barrier in this paracellular pathway. Once viewed as static, it is now ... | digestive system diseases |
Diagnosis and evaluation of renovascular hypertension. Indications for therapy. Renovascular hypertension is caused by two distinct conditions with different causes, fibromuscular dysplasia and atheroma. Diagnosis of the former is both simpler and more rewarding, whereas atheromatous lesions of the renal artery may be ... | cardiovascular diseases |
Mitral valve prolapse: comparison of diagnosis by physical examination and echocardiography To determine how well physical examination findings suggestive of mitral valve prolapse (MVP) correlate with echocardiographic evidence of MVP, we retrospectively reviewed the charts of 104 patients referred to an Air Force Card... | general pathological conditions |
Whole-body lipolysis and triglyceride-fatty acid cycling in cachectic patients with esophageal cancer. Whole-body lipolytic rates and the rate of triglyceride-fatty acid cycling (reesterification of fatty acids released during lipolysis) were measured with stable isotopic tracers in the basal state and during beta-adre... | general pathological conditions |
Neurological and ophthalmological phenomena after aortic conduit surgery. Transient neurological and visual signs have been observed in some patients after valved conduit replacement of the aortic valve and ascending aorta. Twenty-seven patients having valved conduit replacement between February 1982 and October 1988 w... | nervous system diseases |
Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs. We investigated the effects of infusions of ATP-MgCl2 on the circulation in 11 spontaneously breathing newborn lambs during pulmonary hypertension induced either by the infusion of U-46619, a thromboxane A2 mimetic, or by hypoxia. D... | general pathological conditions |
Acute autonomic neuropathy. Two cases and a clinical review. Acute autonomic neuropathy is an uncommon syndrome, usually affecting healthy young people. Presentation is often dramatic and initial misdiagnosis is common. We describe two young women with acute autonomic neuropathy who presented with gastrointestinal invo... | nervous system diseases |
Mild head injury classification. Inconsistencies across studies concerning outcome after mild head injury may reflect differences in the diagnostic criteria used for selection of patients. Consequently, we compared the neurobehavioral outcome in three groups of consecutively hospitalized patients (aged 16 to 50 years) ... | general pathological conditions |
Pancreatic transplantation: radiologic evaluation of vascular complications. Transplantation of the pancreas is an increasingly common therapeutic option for preventing or delaying complications of type I diabetes mellitus. The authors studied the relative roles of various radiologic examinations in diagnosing vascular... | general pathological conditions |
Chronic functional gastrointestinal symptoms in Holocaust survivors. In Nazi-occupied Europe (1939-1945), Jews were submitted to extreme mental and physical hardships (the Holocaust). This study was designed to investigate the impact of the severe protracted suffering on the development of chronic functional gastrointe... | general pathological conditions |
Traumatic asphyxia. Traumatic asphyxia is a distinctive clinical syndrome characterized by cervicofacial cyanosis and edema, multiple petechiae, and subconjunctival hemorrhage after a severe crush injury of the thorax or of the upper part of the abdomen. A case of traumatic asphyxia is reported, and its clinical and pa... | general pathological conditions |
Shoulder arthroplasty for rheumatoid arthritis. Forty-two Designed After Natural Anatomy (DANA) total shoulder arthroplasties (Howmedica, Rutherford, New Jersey) were performed in 34 rheumatoid patients. Thirty shoulders in 23 patients were followed for a minimum of two years. Twelve of the 30 shoulders (40%) had signi... | general pathological conditions |
Portacaval shunt versus endoscopic sclerotherapy in the elective treatment of variceal hemorrhage. Eighty-two consecutive Child-Campbell class A and B cirrhotic patients were included in a prospective controlled trial to assess the efficacy and safety of portacaval anastomosis vs. endoscopic sclerotherapy as elective t... | general pathological conditions |
Short-term course of corticosteroids in the treatment of resistant ascites complicating schistosomal liver disease. The aim of this work was to evaluate the effect of short-term corticosteroids in resistant ascites complicating schistosomal liver disease after 4 wk or more on standard treatment. Thirty-seven patients w... | general pathological conditions |
Hyperthecosis of the ovaries in a woman with a placental site trophoblastic tumor. Rapidly increasing testosterone levels were observed in a patient presenting with sudden onset of virilization. Exploratory laparotomy revealed a placental site trophoblastic tumor in the uterus. Wedge biopsies of the ovaries showed exte... | general pathological conditions |
Gastroesophageal reflux and sclerotherapy strictures. The development of esophageal stricture is common following endoscopic variceal sclerotherapy (EVS). Gastroesophageal reflux may be at least partly responsible. Twelve randomly selected male patients underwent chronic EVS for the management of bleeding esophageal va... | digestive system diseases |
Scalp pilomatrix carcinoma as an extra-axial mass. We report the CT, MRI, and angiographic findings in a case of pilomatrix carcinoma that had invaded the temporal bone and presented itself as an extra-axial mass. Even though bone destruction was better shown with CT, the tumor mass with its meningeal and tentorial ext... | neoplasms |
Extradural haematoma in the Irish Republic: an analysis of 82 cases with emphasis on 'delay'. Eighty-two cases of extradural haematoma were analysed to elucidate the factors contributing to delay in treatment and poor outcome. The majority of cases occurred in the first three decades of life with falls being the common... | nervous system diseases |
Pancreatic ascites presenting in infancy, with review of the literature. We report a 4-month-old boy with massive ascites in whom a diagnosis of pancreatitis was made on a raised ascitic amylase level after two inconclusive laparotomies. He developed a pseudocyst which was managed with repeated percutaneous needle aspi... | general pathological conditions |
Prediction of free phenytoin levels based on [total phenytoin]/[albumin] ratios. Potential errors with hypoalbuminemia. Therapeutic monitoring of the pharmacologically active (free drug) fraction of protein-bound medications (e.g., phenytoin) represents a major diagnostic challenge in clinical and laboratory medicine. ... | nervous system diseases |
Complete left main coronary artery occlusion: angiographic evaluation of collateral vessel patterns and assessment of hemodynamic correlates. An angiographic study of eight patients with total occlusion of the left main coronary artery identified six patients with chronic occlusion and two with acute complete occlusion... | cardiovascular diseases |
Carcinoma of the extrahepatic bile ducts. Thirty-seven patients with carcinoma of the extrahepatic bile ducts (EHBD), diagnosed over 14 years from 1974 to 1987, were studied retrospectively. The most common presenting complaint was jaundice, followed by abdominal pain, nausea and vomiting, and weight loss. The majority... | neoplasms |
The transoral approach for the management of intradural lesions at the craniovertebral junction: review of 7 cases. The main difficulty in dealing with intradural lesions located ventrally in the region of the craniovertebral junction (CVJ) is related to their relative inaccessibility. Posterolateral approaches involve... | general pathological conditions |
Human olfactory discrimination after unilateral frontal or temporal lobectomy. Olfactory discrimination and detection was studied in 106 patients with unilateral cerebral excision in the right or left temporal lobe, right or left frontal lobe, left parietal lobe, or right frontal and temporal lobes, and in 20 normal co... | nervous system diseases |
Flecked retina associated with ring 17 chromosome. We report the case of a mentally retarded male with a ring 17 chromosome who had subretinal drusen-like deposits in each eye. This is the second report of flecked retina in a patient with ring 17 chromosome, suggesting that there may be a causal relationship between ab... | general pathological conditions |
Pharynx: value of oblique projections for radiographic examination. The utility of oblique views for augmenting standard posteroanterior and lateral double-contrast radiography of the pharynx was examined. Over an 8-month period, two oblique views were added to the standard posteroanterior and lateral views of the phar... | digestive system diseases |
Delayed positive gastrointestinal bleeding studies with technetium-99m-red blood cells: utility of a second injection. Two patients studied with technetium-99m-labeled red blood cells (RBCs) for gastrointestinal bleeding had positive findings only on 24-hr delayed images, at which time the site of bleeding could not be... | general pathological conditions |
Potentially lethal ventricular arrhythmias. Minimizing the danger. Patients with potentially lethal ventricular arrhythmias are at an increased risk of sudden death. Antiarrhythmic drugs, with the exception of beta blockers and possibly amiodarone, have not been particularly effective in reducing mortality. Beta blocke... | cardiovascular diseases |
Enhanced hepatic drug clearance in patients with cystic fibrosis. To examine whether hepatic drug metabolism is altered in patients with cystic fibrosis (CF), we evaluated the pharmacokinetics of three model pharmacologic substrates (antipyrine, a marker of hepatic oxidative metabolism; lorazepam, a marker of hepatic g... | neoplasms |
Discontinuation of antiepileptic drugs in children who have outgrown epilepsy: effects on cognitive function. Cognitive function is frequently impaired in children with epilepsy, compared with age-matched controls. It can be hard to evaluate the significance of various contributory factors. The effects of antiepileptic... | nervous system diseases |
Idiopathic hypereosinophilic syndrome terminating as disseminated T-cell lymphoma. The authors describe a case of idiopathic hypereosinophilic syndrome (HES) terminated as a T-cell lymphoma in a 3-year-old girl. The clinical course was chronic and characterized by chronic eczema, persistent peripheral blood eosinophili... | general pathological conditions |
Ultrasonography compared with intravenous urography in the investigation of adults with haematuria OBJECTIVE--To compare ultrasonography with intravenous urography in the investigation of adults with haematuria. DESIGN--Prospective study entailing the examination of all patients with both investigations concurrently. T... | general pathological conditions |
Usefulness of antithrombotic therapy in resting angina pectoris or non-Q-wave myocardial infarction in preventing death and myocardial infarction (a pilot study from the Antithrombotic Therapy in Acute Coronary Syndromes Study Group). In a prospective pilot trial of antithrombotic therapy in the acute coronary syndrome... | cardiovascular diseases |
Debulking of pelvic and para-aortic lymph node metastases in ovarian cancer with the cavitron ultrasonic surgical aspirator. Six patients with metastatic ovarian cancer with extensive involvement of the pelvic and/or para-aortic lymph nodes underwent surgical debulking with the Cavitron Ultrasonic Surgical Aspirator. I... | neoplasms |
Blunt intestinal injury. Keys to diagnosis and management. Fifty-six patients with blunt intestinal injury seen during 39 months were reviewed for keys to diagnosis and treatment. Motor vehicle accidents were involved in 80% of the cases and seat/lap belts were in use 69% of the time. Blunt intestinal injury was the on... | digestive system diseases |
Protective role of vitamin E in biological systems. Vitamin E is well accepted as nature's most effective lipid-soluble, chain-breaking antioxidant, protecting cell membranes from peroxidative damage. Free-radical-mediated pathology has been implicated in the development over time of degenerative diseases and condition... | general pathological conditions |
Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. An increase in extracellular K+ concentration ([K+]c) of the rat hippocampus following fluid-percussion concussive brain injury was demonstrated with microdialysis. The role of neuronal discharge ... | nervous system diseases |
Malignant thymoma presenting as intracardiac tumor and superior vena caval obstruction. A case of malignant thymoma with intracardiac infiltration and intrinsic superior vena caval obstruction due to the tumor is reported. Intracardiac invasion by a thymoma is rare and for this reason is believed worthy of a report. | cardiovascular diseases |
Coronary lesion morphology in acute myocardial infarction: demonstration of early remodeling after streptokinase treatment Coronary lesion morphology was analyzed in 72 patients 1 to 8 days after streptokinase treatment for acute myocardial infarction and compared with lesion morphology in a control group of 24 patient... | cardiovascular diseases |
Surgical results of intrathoracic gastric volvulus complicating hiatal hernia. From 1981 to 1988, 138 patients with hiatal hernia were treated surgically at our centre. Twenty-one (mean age 76.6 years, 17 women, four men) had an associated intrathoracic gastric volvulus. Eleven patients (mean age 73.2 years), of whom e... | digestive system diseases |
Rehabilitation of quadriparesis secondary to spinal cord sarcoidosis. Sarcoidosis is a multisystem granulomatous disorder that rarely involves the spinal cord. This report describes the presentation and rehabilitative course of a 31-yr-old man with quadriparesis secondary to spinal cord sarcoidosis. The patient had ins... | nervous system diseases |
Reactivity of eccentric and concentric coronary stenoses in patients with chronic stable angina. Dynamic coronary stenoses may be the cause of a variable angina threshold and rest angina in patients with chronic stable angina. It has been suggested that eccentric but not concentric coronary artery stenoses have the pot... | general pathological conditions |
Coronary artery bypass grafting in elderly patients. Comparative results in a consecutive series of 469 patients older than 75 years. A consecutive series of 7104 patients undergoing isolated coronary artery bypass grafting during an 18-year period (1971 to 1988) included 469 patients older than 75 years. Results were ... | general pathological conditions |
Normal and abnormal pituitary glands: gadopentetate dimeglumine-enhanced MR imaging. Dynamic magnetic resonance (MR) imaging with a 1.5-T superconductive unit was used in the evaluation of nine normal pituitary glands and 10 pituitary adenomas, including four microadenomas and six macroadenomas. Seven to 10 images were... | neoplasms |
Restricted dose and duration of corticosteroid treatment in patients with polymyalgia rheumatica and temporal arteritis. To analyze whether corticosteroids in low doses during limited time periods could be safely used in the treatment of patients with polymyalgia rheumatica (PMR) or temporal arteritis (TA) the records ... | cardiovascular diseases |
Assessment of the risk of bleeding from esophageal varices by continuous monitoring of portal pressure. Portal pressure was monitored by means of an indwelling hepatic vein balloon catheter in patients with alcoholic cirrhosis and bleeding varices to determine the safety and feasibility of the technique and its value i... | general pathological conditions |
Hemodynamic profiles of prostaglandin E1, isoproterenol, prostacyclin, and nifedipine in experimental porcine pulmonary hypertension. BACKGROUND AND METHODS: We compared the hemodynamic effects of four vasodilators in experimental embolic pulmonary hypertension in a randomized controlled trial, using nine pigs weighing... | cardiovascular diseases |
Subcutaneous emphysema producing airway compromise after anesthesia for reduction of a mandibular fracture. A case report and review of the literature. Subcutaneous emphysema can occur as the result of trauma, surgery, and anesthesia. A case is presented of extensive subcutaneous emphysema after anesthesia for oral sur... | general pathological conditions |
A rhesus monkey model for sexual transmission of a papillomavirus isolated from a squamous cell carcinoma. Recently we molecularly cloned and characterized a papillomavirus from a lymph node metastasis of a primary penile carcinoma found in a rhesus monkey; this virus species, rhesus papillomavirus type 1 (RhPV-1), is ... | neoplasms |
Effect of interleukin-1-beta on metastasis formation in different tumor systems. Experiments were done to determine the effect of interleukin-1-beta (IL-1 beta) on metastasis formation in different tumor systems. Intravenous administration of 1 microgram of human recombinant IL-1 beta given 1 hour before tumor cell inj... | general pathological conditions |
Simultaneous bilateral hernia repair. A case against conventional wisdom. The timing of bilateral hernia repair remains controversial. Because of reported high recurrence rates after simultaneous bilateral repair, staged procedures have been suggested. This study determined recurrence and complication rates of unilater... | digestive system diseases |
Effect of normal MSAFP screening on maternal age for genetic amniocentesis. Routine maternal serum alpha-fetoprotein (MSAFP) screening for neural tube defects is considered by many to be standard obstetrical care, and recently many have encouraged this test to screen for Trisomy-21 (Down's syndrome). We questioned whet... | nervous system diseases |
Aspergillus terreus endophthalmitis in a patient with chronic lymphocytic leukemia. A 65-year-old woman with a 7-year history of chronic lymphocytic leukemia presented with acute visual loss, pain, and redness in her right eye. Results of stains and cultures of anterior chamber fluid were negative. Neurologic problems,... | cardiovascular diseases |
Heparin-induced thrombocytopenia in patients who undergo open heart surgery. To determine whether heparin-dependent antiplatelet antibodies (HAAb) have an effect on morbidity and/or mortality rates, we reviewed the cases of 3438 patients who underwent open heart surgery from 1981 to 1989. Forty-six patients (1.3%) had ... | cardiovascular diseases |
Thrombin stimulates tumor-platelet adhesion in vitro and metastasis in vivo. Recent studies have revealed a role for platelets and the platelet-adhesive proteins, fibronectin and von Willebrand factor (vWF) in platelet-tumor cell interaction in vitro and metastasis in vivo. The present report documents the effect of th... | general pathological conditions |
Treatment of anorectal abscess with or without primary fistulectomy. Results of a prospective randomized trial. To determine whether primary fistulectomy should be performed or not at the time of incision and drainage, a prospective, randomized study in 70 patients with anorectal abscess was conducted. Thirty-six patie... | general pathological conditions |
Rash after treatment with anistreplase. A palpable purpura developed on the legs and lower abdomen of a woman of 54 five days after she was treated with anistreplase anisoylated plasminogen streptokinase activator complex (APSAC) for an acute myocardial infarction. Histological examination of a skin biopsy specimen tak... | cardiovascular diseases |
The epithelial changes associated with squamous cell carcinoma of the vulva: a review of the clinical, histological and viral findings in 78 women. Seventy-eight excised specimens of squamous cell carcinoma of the vulva were reviewed retrospectively for the presence of lichen sclerosus or vulvar intraepithelial neoplas... | general pathological conditions |
Growth of cultured human cerebral meningiomas is inhibited by dopaminergic agents. Presence of high affinity dopamine-D1 receptors. We have found that microM concentrations of the dopamine agonist bromocriptine significantly decrease the proliferation rate of human meningioma cells in culture (25-56% inhibition). This ... | neoplasms |
Emergent aneurysm surgery without cerebral angiography for the comatose patient Neurologically based clinical grading scales offer excellent prognostic information for the patient suffering diffuse subarachnoid hemorrhage (SAH). These grading scales are less applicable to patients with life-threatening intraparenchymal... | general pathological conditions |
Prognostic value of thallium-201 myocardial perfusion imaging in patients with unstable angina who respond to medical treatment [published erratum appears in J Am Coll Cardiol 1991 Sep;18(3):889] Although the prognostic value of thallium-201 imaging is well established, its ability to risk stratify patients who present... | cardiovascular diseases |
Gadolinium-MRI in acute transverse myelopathy. A patient with acute transverse myelopathy (ATM) had serial magnetic resonance imaging (MRI) studies before and after administration of gadolinium (Gd-DTPA). Gd-DTPA-MRI was useful in estimating the pathologic extent and residual deficit expected in ATM. | nervous system diseases |
Photochemotherapy alone or combined with interferon alpha-2a in the treatment of cutaneous T-cell lymphoma. Eighty-two patients with either mycosis fungoides (MF) or parapsoriasis en plaques were treated with psoralens ultraviolet A light (PUVA). Clinical and histologic parameters were followed for a period from 6 mont... | neoplasms |
Undifferentiated carcinomas of salivary glands. Undifferentiated carcinomas of salivary glands are those epithelial malignancies whose light-optic histopathologic features are not sufficient to place them in other defined classes of carcinoma. They are ultrastructurally heterogeneous and can manifest neuroendocrine dif... | neoplasms |
Involvement of thromboxane and neutrophils in multiple-system organ edema with interleukin-2. Interleukin-2 (IL-2) produces toxicity characterized by generalized edema within 24 hours. This study tests whether the rate of IL-2 administration modulates the onset of edema and examines thromboxane (Tx) and neutrophils as ... | digestive system diseases |
Intraoperative blood pressure. What patterns identify patients at risk for postoperative complications? While monitoring blood pressure is a routine part of intraoperative management, several methods have been proposed to characterize intraoperative hemodynamic patterns as predictors of postoperative complications. In ... | general pathological conditions |
Long-term effects of nimodipine on cerebral infarcts and outcome after aneurysmal subarachnoid hemorrhage and surgery. A total of 213 patients with verified aneurysmal subarachnoid hemorrhage (SAH) of Grades I to III (Hunt and Hess classification) were enrolled in a double-blind placebo-controlled trial to determine th... | cardiovascular diseases |
Results and complications of angioplasty in aortoiliac disease Percutaneous transluminal angioplasty was used to treat 340 aortoiliac lesions in 200 patients who were followed for as long as 90 months (mean, 28.7 months; median, 23 months). The initial success rate was 94.7% for lesions and 93.0% for patients. The indi... | cardiovascular diseases |
Thoracic spinal fractures and aortic rupture: a significant and fatal association. We analyzed the frequency of occurrence of traumatic aortic rupture (TAR) in patients with and without thoracic spinal fractures. Among 4,676 blunt chest trauma victims admitted to the hospital between 1972 and 1988, 148 (3.2%) suffered ... | cardiovascular diseases |
Pathophysiological insights into the cardiomyopathy of Chagas' disease. The evidence gained from both human and animal studies of chronic chagasic cardiomyopathy suggests that the disease occurs as a consequence of several discrete and progressive pathophysiological processes occurring after infection, the ultimate exp... | cardiovascular diseases |
Ability of circular extrachromosomal DNA molecules to carry amplified MYCN proto-oncogenes in human neuroblastomas in vivo. Amplification of the proto-oncogene MYCN (also known as N-myc) in neuroblastomas has been shown to correlate with both disease stage and prognosis, yet little is known about the DNA structures tha... | neoplasms |
Head and neck cancer and ageing: a retrospective study in 438 patients. To evaluate whether age over 70 years represents a prognostic factor in head and neck cancer, we reviewed all cases observed between 1981 and 1984. Four hundred and thirty-eight (438) patients were considered in relation to three age groups (less t... | neoplasms |
Ventilatory and diffusion abnormalities in potential heart transplant recipients. Few data are available concerning pulmonary function in patients with severe chronic congestive heart failure. Of 315 patients evaluated for potential cardiac transplantation at UCLA, 132 underwent pulmonary function tests. The latter pat... | cardiovascular diseases |
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