SMILES
stringlengths
19
90
Deep SMILES
stringlengths
17
95
SELFIES
stringlengths
75
279
SAFE
stringlengths
19
104
Group SELFIES
stringlengths
73
282
DBPP
float64
0
1
RA
float64
0
0.99
SYBA
float64
-89.22
201
QED
float64
0.14
0.95
SA
float64
1.5
6.28
NP
float64
-3.66
2.11
logP
float64
-4.52
3.94
Weight
float64
250
350
Rings
float64
0
7
gsk3b_current
float64
0
0
jnk3_current
float64
0
0.41
drd2_current
float64
0
1
Celecoxib
float64
0
0.4
Troglitazone
float64
0.02
0.28
Thiothixene
float64
0.01
0.4
Aripiprazole
float64
0.1
0.69
Albuterol
float64
0.08
0.7
Mestranol
float64
0.02
0.47
Median 1
float64
0
0.24
Median 2
float64
0
0.23
c7h8n2o2
float64
0
0.65
c9h10n2o2pf2cl
float64
0
0.83
Osimertinib
float64
0
0.8
Fexofenadine
float64
0
0.68
Ranolazine
float64
0
0.17
Perindopril
float64
0
0.48
Amlodipine
float64
0
0.55
Sitagliptin
float64
0
0.47
Zaleplon
float64
0
0.58
valsartan_smarts
float64
0
0
Deco Hop
float64
0.5
0.87
Scaffold Hop
float64
0.07
0.51
Penalized logP
float64
-33.39
2.7
C=CC(C)(C)C(=O)N1CCC2(CC1)CN(CCc1cccs1)C2
C=CCC)C)C=O)NCCCCC6))CNCCccccs5)))))))C4
[C][=C][C][Branch1][C][C][Branch1][C][C][C][=Branch1][C][=O][N][C][C][C][Branch1][Branch1][C][C][Ring1][=Branch1][C][N][Branch1][#Branch2][C][C][C][=C][C][=C][S][Ring1][Branch1][C][Ring1][=N]
N13CCC2(CC1)CN4C2.C=CC(C)(C)C3=O.c15cccs1.C4C5
[C][=C][C][Branch][C][pop][Branch][C][pop][C][=Branch][=O][pop][N][C][C][C][Branch][C][C][Ring1][=Branch][pop][C][N][Branch][C][C][C][=C][C][=C][S][Ring1][Branch][pop][C][Ring1][S]
0.017831
0.6777
56.221167
0.771417
3.345898
-1.222148
3.4272
332.513
3
0
0.05
0.447504
0.071429
0.111111
0.18254
0.31694
0.212766
0.232751
0.078023
0.090847
0
0
0.000225
0.000382
0.02743
0.120087
0.318689
0
0.000205
0
0.759777
0.348107
0.49426
CC[C@H](COC)NC(=O)N1CC2(CCCC2)[C@@H]1C(C)C
CC[C@H]COC)))NC=O)NCCCCCC5))))[C@@H]4CC)C
[C][C][C@H1][Branch1][Ring2][C][O][C][N][C][=Branch1][C][=O][N][C][C][Branch1][#Branch1][C][C][C][C][Ring1][Branch1][C@@H1][Ring1][Branch2][C][Branch1][C][C][C]
N14CC2(CCCC2)[C@@H]17.CC[C@@H]6C5.C34=O.C7(C)C.O5C.N36
[C][C][CH1][Branch][C][O][C][pop][N][C][=Branch][=O][pop][N][C][C][Branch][C][C][C][C][Ring1][Branch][pop][CH1][Branch][C][Branch][C][pop][C][pop][Ring1][O]
0.002661
0.250917
16.477302
0.841887
4.154506
0.159428
3.0216
282.428
2
0
0
0.000865
0.02439
0.101563
0.085271
0.218579
0.148148
0.207018
0.142698
0.059459
0
0
0.00523
0.0096
0.034643
0.008655
0.116334
0
0.000013
0
0.752347
0.336879
-0.758633
CCCCN1CCO[C@H]2CCN(C(=O)c3cn(C)nn3)C[C@H]21
CCCCNCCO[C@H]CCNC=O)ccnC)nn5))))))C[C@H]6%10
[C][C][C][C][N][C][C][O][C@H1][C][C][N][Branch1][#C][C][=Branch1][C][=O][C][=C][N][Branch1][C][C][N][=N][Ring1][=Branch1][C][C@H1][Ring1][=C][Ring2][Ring1][C]
N15CCO[C@H]2CCN4C[C@H]21.c16cn(C)nn1.CCCC5.C46=O
[C][C][C][C][N][C][C][O][CH1][C][C][N][Branch][C][=Branch][=O][pop][C][=C][N][Branch][C][pop][N][=N][Ring1][=Branch][pop][C][CH1][Ring2][Ring1][Branch][Ring1][P]
0.019339
0.809408
47.687727
0.811816
3.457966
-1.604062
0.5305
307.398
3
0
0.02
0.015355
0.046875
0.07971
0.129771
0.292683
0.136054
0.237624
0.101622
0.097483
0
0
0.129422
0.162937
0.002528
0.154088
0.306186
0.000016
0.003075
0
0.768464
0.361234
-1.659749
C[S@@](=N)(=O)c1ccc(NC(=O)NC(CF)CF)cc1
C[S@@]=N)=O)ccccNC=O)NCCF))CF))))))cc6
[C][S@@][=Branch1][C][=N][=Branch1][C][=O][C][=C][C][=C][Branch1][=C][N][C][=Branch1][C][=O][N][C][Branch1][Ring1][C][F][C][F][C][=C][Ring1][#C]
C[S@@](=N)(=O)c1ccc5cc1.C4(CF)CF.C23=O.N25.N34
[C][S][=Branch][=N][pop][=Branch][=O][pop][C][=C][C][=C][Branch][N][C][=Branch][=O][pop][N][C][Branch][C][F][pop][C][F][pop][C][=C][Ring2][Ring1][C]
0.069872
0.751709
50.148687
0.776552
3.138549
-1.313614
2.15117
291.323
1
0
0
0.000224
0.196078
0.122951
0.162393
0.309524
0.329004
0.126984
0.031607
0.092155
0.000005
0.062937
0.381959
0.445992
0.029587
0.103822
0.006673
0.18296
0.006701
0
0.77405
0.369675
-0.146616
O=C(CCn1cnnn1)NCC1(O)CN(Cc2cccnc2)C1
O=CCCncnnn5)))))))NCCO)CNCccccnc6)))))))C4
[O][=C][Branch1][#Branch2][C][C][N][C][=N][N][=N][Ring1][Branch1][N][C][C][Branch1][C][O][C][N][Branch1][#Branch2][C][C][=C][C][=C][N][=C][Ring1][=Branch1][C][Ring1][N]
C17(O)CN5C1.c18cccnc1.O=C3CC6.n16cnnn1.N34.C47.C58
[O][=C][Branch][C][C][N][C][=N][N][=N][Ring1][Branch][pop][N][C][C][Branch][O][pop][C][N][Branch][C][C][=C][C][=C][N][=C][Ring1][=Branch][pop][C][Ring1][#C]
0.002372
0.902857
89.415181
0.661424
2.678764
-2.02468
-1.1787
317.353
3
0
0
0.00235
0.07874
0.101449
0.126866
0.285714
0.275362
0.178427
0.042563
0.07758
0
0.000006
0.719409
0.52578
0.000144
0.295468
0.329435
0
0.040196
0
0.787294
0.389689
-1.916558
Cn1nccc1C(=O)N[C@@H]1CCC[C@H]1CNCc1nc(C2CC2)no1
Cnnccc5C=O)N[C@@H]CCC[C@H]5CNCcncCCC3)))no5
[C][N][N][=C][C][=C][Ring1][Branch1][C][=Branch1][C][=O][N][C@@H1][C][C][C][C@H1][Ring1][Branch1][C][N][C][C][=N][C][Branch1][=Branch1][C][C][C][Ring1][Ring1][=N][O][Ring1][Branch2]
Cn1nccc17.[C@@H]16CCC[C@H]19.c18nc%10no1.C37=O.C1%10CC1.N36.C49.N45.C58
[C][N][N][=C][C][=C][Branch][C][=Branch][=O][pop][N][CH1][C][C][C][CH1][Branch][C][N][C][C][=N][C][Branch][C][C][C][Ring1][Ring1][pop][=N][O][Ring1][O][pop][Ring1][Branch][pop][Ring1][Branch]
0.003572
0.865327
87.293852
0.787128
3.484994
-1.851067
1.3688
344.419
4
0
0.01
0.016944
0.075188
0.097222
0.113475
0.237037
0.226667
0.198198
0.091734
0.096695
0
0
0.688892
0.516261
0.011735
0.391441
0.113739
0.001744
0.007361
0
0.775791
0.372306
-1.107719
Cc1cc(C(=O)NC[C@H]2CCCC[C@H]2NC(=O)c2ccc[nH]2)ns1
CcccC=O)NC[C@H]CCCC[C@H]6NC=O)cccc[nH]5))))))))))))))))ns5
[C][C][=C][C][Branch2][Ring1][O][C][=Branch1][C][=O][N][C][C@H1][C][C][C][C][C@H1][Ring1][=Branch1][N][C][=Branch1][C][=O][C][=C][C][=C][NH1][Ring1][Branch1][=N][S][Ring2][Ring1][#Branch1]
[C@H]19CCCC[C@H]16.Cc1cc7ns1.c18ccc[nH]1.C37=O.C48=O.N35.C59.N46
[C][C][=C][C][Branch][C][=Branch][=O][pop][N][C][CH1][C][C][C][C][CH1][Branch][N][C][=Branch][=O][pop][C][=C][C][=C][N][Ring1][Branch][pop][Ring1][=Branch][pop][=N][S][Ring2][Ring1][=N]
0.002801
0.735006
69.097659
0.777238
3.637615
-0.781265
2.49822
346.456
3
0
0.01
0.001549
0.111111
0.131387
0.140741
0.304462
0.233677
0.20653
0.088889
0.103036
0
0
0.426946
0.536849
0.050009
0.420084
0.39841
0.039468
0.060112
0
0.770131
0.363753
-0.5034
COC[C@@](C)(O)C(=O)NCC1(C(=O)OC)CCOCC1
COC[C@@]C)O)C=O)NCCC=O)OC)))CCOCC6
[C][O][C][C@@][Branch1][C][C][Branch1][C][O][C][=Branch1][C][=O][N][C][C][Branch1][#Branch1][C][=Branch1][C][=O][O][C][C][C][O][C][C][Ring1][#Branch2]
C4[C@@](C)(O)C3=O.C167CCOCC1.C26=O.CO4.N35.C57.O2C
[C][O][C][C][Branch][C][pop][Branch][O][pop][C][=Branch][=O][pop][N][C][C][Branch][C][=Branch][=O][pop][O][C][pop][C][C][O][C][C][Ring1][=N]
0.002909
0.204321
38.196554
0.63844
3.472816
0.099424
-0.5302
289.328
1
0
0
0.001584
0.033058
0.111111
0.085938
0.246499
0.149813
0.179156
0.105839
0.055046
0
0
0.615461
0.464935
0.000476
0.007512
0.006586
0
0.002203
0
0.760404
0.349055
-2.417077
CC(C)(C)OC(=O)N1CCN(C(=O)NCCNC(=O)C2CC2)CC1
CCC)C)OC=O)NCCNC=O)NCCNC=O)CCC3)))))))))CC6
[C][C][Branch1][C][C][Branch1][C][C][O][C][=Branch1][C][=O][N][C][C][N][Branch2][Ring1][C][C][=Branch1][C][=O][N][C][C][N][C][=Branch1][C][=O][C][C][C][Ring1][Ring1][C][C][Ring1][P]
N14CCN5CC1.CC8(C)C.C34=O.C56=O.C9C%10.C7%11=O.C1%11CC1.O38.N69.N7%10
[C][C][Branch][C][pop][Branch][C][pop][O][C][=Branch][=O][pop][N][C][C][N][Branch][C][=Branch][=O][pop][N][C][C][N][C][=Branch][=O][pop][C][C][C][Ring1][Ring1][pop][C][C][Ring2][Ring1][Ring2]
0.045016
0.936934
138.70067
0.739893
2.092533
-1.540553
0.7749
340.424
2
0
0.01
0.003561
0.038168
0.078571
0.12782
0.20202
0.133333
0.120664
0.105882
0.07431
0
0
0.543146
0.470765
0.004611
0.008692
0.116784
0.000019
0.000062
0
0.754967
0.340839
0.148796
C[C@@H](c1nnnn1C)N(CCNC(=O)[C@@H]1CCCN1C)C1CC1
C[C@@H]cnnnn5C))))))NCCNC=O)[C@@H]CCCN5C))))))))))CCC3
[C][C@@H1][Branch1][=Branch2][C][=N][N][=N][N][Ring1][Branch1][C][N][Branch1][S][C][C][N][C][=Branch1][C][=O][C@@H1][C][C][C][N][Ring1][Branch1][C][C][C][C][Ring1][Ring1]
c18nnnn1C.[C@@H]17CCCN1C.C[C@H]38.N346.C4C5.C27=O.C16CC1.N25
[C][CH1][Branch][C][=N][N][=N][N][Branch][C][pop][Ring1][Branch][pop][N][Branch][C][C][N][C][=Branch][=O][pop][CH1][C][C][C][N][Branch][C][pop][Ring1][Branch][pop][C][C][C][Ring1][Ring1]
0.010561
0.355668
44.862998
0.758228
3.548291
-1.751713
-0.0541
321.429
3
0
0.01
0.008918
0.038462
0.071429
0.120301
0.26455
0.12
0.174312
0.133601
0.083091
0
0
0.38815
0.368848
0.001059
0.16671
0.276289
0
0.000144
0
0.772335
0.367083
-2.175693
C[C@H](N[C@H]1CC[C@@H](CN)C1)c1ccnn1-c1ccccc1
C[C@H]N[C@H]CC[C@@H]CN))C5))))))cccnn5-cccccc6
[C][C@H1][Branch1][=N][N][C@H1][C][C][C@@H1][Branch1][Ring1][C][N][C][Ring1][#Branch1][C][=C][C][=N][N][Ring1][Branch1][C][=C][C][=C][C][=C][Ring1][=Branch1]
[C@H]13CC[C@@H]5C1.c14ccnn16.c16ccccc1.C[C@H]24.N23.C5N
[C][CH1][Branch][N][CH1][C][C][CH1][Branch][C][N][pop][C][Ring1][#Branch][pop][C][=C][C][=N][N][Branch][C][=C][C][=C][C][=C][Ring1][=Branch][pop][Ring1][Branch]
0.074667
0.385883
24.942204
0.887213
3.398282
-1.035604
2.6503
284.407
3
0
0
0.050886
0.168142
0.105263
0.177419
0.297521
0.310078
0.194794
0.108366
0.105944
0
0
0.044811
0.086653
0.037004
0.344447
0.374828
0.002172
0.018983
0
0.775634
0.372069
-0.110236
CCOC(=O)[C@@H](C[C@H]1CCCO1)NC(=O)Cn1nc(C)n(C)c1=O
CCOC=O)[C@@H]C[C@H]CCCO5))))))NC=O)CnncC)nC)c5=O
[C][C][O][C][=Branch1][C][=O][C@@H1][Branch1][=Branch2][C][C@H1][C][C][C][O][Ring1][Branch1][N][C][=Branch1][C][=O][C][N][N][=C][Branch1][C][C][N][Branch1][C][C][C][Ring1][#Branch1][=O]
n16nc(C)n(C)c1=O.C2(=O)[C@H]5C7.[C@H]17CCCO1.C3(=O)C6.CC4.O24.N35
[C][C][O][C][=Branch][=O][pop][CH1][Branch][C][CH1][C][C][C][O][Ring1][Branch][pop][N][C][=Branch][=O][pop][C][N][N][=C][Branch][C][pop][N][Branch][C][pop][C][=Branch][=O][pop][Ring1][#Branch]
0.00104
0.857123
70.890264
0.67161
3.352856
-1.041845
-0.49278
340.38
2
0
0.01
0.000896
0.070313
0.117647
0.110294
0.260417
0.132013
0.164502
0.117065
0.104036
0
0
0.673274
0.468165
0.000551
0.198945
0.152628
0
0.003859
0
0.780397
0.379266
-2.247068
C#CCNC(=O)CN1CCCN(C(=O)CC(=O)OC)CC1
C#CCNC=O)CNCCCNC=O)CC=O)OC)))))CC7
[C][#C][C][N][C][=Branch1][C][=O][C][N][C][C][C][N][Branch1][N][C][=Branch1][C][=O][C][C][=Branch1][C][=O][O][C][C][C][Ring1][=C]
N16CCCN4CC1.C4(=O)CC2=O.C3(=O)C6.C#CC5.N35.O2C
[C][#C][C][N][C][=Branch][=O][pop][C][N][C][C][C][N][Branch][C][=Branch][=O][pop][C][C][=Branch][=O][pop][O][C][pop][C][C][Ring1][P]
0.020172
0.927579
94.509426
0.39285
2.364079
-1.858092
-1.1668
295.339
1
0
0
0.003889
0.032
0.058824
0.134921
0.319088
0.097222
0.173028
0.054209
0.070186
0
0.000002
0.372277
0.394735
0.000146
0.008305
0.005979
0
0.02557
0
0.756729
0.343502
-5.026969
CCc1nsc(NC[C@@H](NC(=O)CC2CC2)C2CCCC2)n1
CCcnscNC[C@@H]NC=O)CCCC3))))))CCCCC5))))))))n5
[C][C][C][=N][S][C][Branch2][Ring1][Branch2][N][C][C@@H1][Branch1][N][N][C][=Branch1][C][=O][C][C][C][C][Ring1][Ring1][C][C][C][C][C][Ring1][Branch1][=N][Ring2][Ring1][Ring2]
c17nsc6n1.C18CCCC1.C4[C@@H]58.C3(=O)C9.C19CC1.CC7.N46.N35
[C][C][C][=N][S][C][Branch][N][C][CH1][Branch][N][C][=Branch][=O][pop][C][C][C][C][Ring1][Ring1][pop][C][C][C][C][C][Ring1][Branch][pop][=N][Ring2][Ring1][#Branch]
0.001357
0.848421
85.800469
0.771948
3.264198
-1.096035
2.9875
322.478
3
0
0
0.004628
0.03876
0.071942
0.080292
0.229167
0.182456
0.171021
0.101622
0.065645
0
0
0.103804
0.20573
0.062168
0.167459
0.292013
0.000899
0.001586
0
0.768306
0.360996
0.285723