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stringlengths 20
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|---|---|
The spleen was also removed .
|
[] |
The end of the pancreas was suture ligated .
|
[] |
Her post-operative recovery was uneventful .
|
[] |
Histological examination of the specimen showed a well circumscribed ovoid tumour 60 mm x 50 mm across .
|
[
{
"entity_text": "tumour",
"type": "CLINENTITY"
}
] |
Sections revealed islands and trabeculae of regular cells with variable amounts of eosinophilic cytoplasm , mostly regular nuclei with indistinct nucleoli .
|
[] |
Areas of necrosis were present with hemorrhage .
|
[
{
"entity_text": "necrosis",
"type": "CLINENTITY"
},
{
"entity_text": "hemorrhage",
"type": "CLINENTITY"
}
] |
A fibrous pseudo-capsule was noted around the tumour and the resection of the tumour appeared complete .
|
[
{
"entity_text": "tumour",
"type": "CLINENTITY"
}
] |
No capsular of vascular invasion was seen .
|
[] |
Immuno-peroxidase staining was positive for chromogranin A .
|
[] |
Synaptophysin was strongly positive , CD 10 was negative , Ki- 67 was less than 2 % positive and the mitotic count was between 2-20 per 10 hpf .
|
[] |
The staining reactions were confirmatory of a neuroendocrine carcinoma of the pancreas .
|
[
{
"entity_text": "neuroendocrine carcinoma of the pancreas",
"type": "CLINENTITY"
}
] |
The final staging of the completely excised tumour was T 3 N 0 M 0 .
|
[] |
Following discharge , she was followed up regularly and remains symptom free .
|
[] |
A CT Scan performed 2 years after surgery showed no evidence of tumour recurrence .
|
[] |
A 49 - year-old white Caucasian woman presented with vaginal bleeding .
|
[
{
"entity_text": "vaginal bleeding",
"type": "CLINENTITY"
}
] |
A pelvic examination revealed a cystic lesion arising from her cervix .
|
[
{
"entity_text": "cystic lesion",
"type": "CLINENTITY"
}
] |
Examination of a biopsy specimen revealed a poorly differentiated neoplasm , with sheets of small hyperchromatic cells , staining weakly for neuroendocrine markers .
|
[] |
She was diagnosed with small cell carcinoma and started on concurrent chemotherapy and radiation .
|
[
{
"entity_text": "small cell carcinoma",
"type": "CLINENTITY"
}
] |
However , additional positive immunostaining for CD 99 was strongly suggestive of Ewing ' s sarcoma .
|
[
{
"entity_text": "Ewing ' s sarcoma",
"type": "CLINENTITY"
}
] |
Fluorescence in situ hybridization revealed ESWR 1 gene rearrangement , confirming Ewing ' s sarcoma .
|
[
{
"entity_text": "Ewing ' s sarcoma",
"type": "CLINENTITY"
}
] |
Our patient underwent surgery , which confirmed stage IIB Ewing ' s sarcoma .
|
[
{
"entity_text": "Ewing ' s sarcoma",
"type": "CLINENTITY"
}
] |
She received adjuvant chemotherapy but died from progressive metastatic disease after four cycles .
|
[
{
"entity_text": "metastatic disease",
"type": "CLINENTITY"
}
] |
A 62 - year-old woman presented with complaints of epigastric pain and vomiting .
|
[
{
"entity_text": "epigastric pain",
"type": "CLINENTITY"
}
] |
Computed tomography showed a 27 - mm , hyper-enhancing tumor in the prepyloric antrum .
|
[
{
"entity_text": "tumor",
"type": "CLINENTITY"
}
] |
Upper endoscopy also showed a submucosal tumor causing subtotal obstruction of the gastric outlet .
|
[
{
"entity_text": "submucosal tumor",
"type": "CLINENTITY"
}
] |
Because a gastrointestinal stromal tumor was suspected , distal gastrectomy was performed .
|
[
{
"entity_text": "gastrointestinal stromal tumor",
"type": "CLINENTITY"
}
] |
Histopathological examination revealed spindle cell proliferation in the submucosal layer .
|
[
{
"entity_text": "spindle cell proliferation",
"type": "CLINENTITY"
}
] |
The spindle cells had invaded the muscularis propria layer and extended to the subserosal layer .
|
[] |
The tumor was finally diagnosed as an IFP based on immunohistochemical findings .
|
[
{
"entity_text": "tumor",
"type": "CLINENTITY"
}
] |
No mutations were identified in the platelet-derived growth factor receptor alpha ( PDGFRA ) gene via molecular genetic analysis .
|
[] |
A 36 - year-old female showed mild swelling in the right upper eyelid .
|
[] |
She lost her RGP contact lens seven months prior to her first visit , from trauma by her child ' s kick to the right eye .
|
[] |
At the first examination , we felt a firm lump inferior to the right brow .
|
[
{
"entity_text": "lump",
"type": "CLINENTITY"
}
] |
Eversion of the upper eyelid also revealed a firm subconjunctival mass superior to the upper tarsus .
|
[
{
"entity_text": "subconjunctival mass",
"type": "CLINENTITY"
}
] |
After incising the conjunctiva , the RGP contact lens was found without a fibrous capsule and granulation tissue in the subconjunctival space .
|
[] |
Three years after removal of the lens , the patient did not show any complications , including ptosis .
|
[
{
"entity_text": "ptosis",
"type": "CLINENTITY"
}
] |
A 17 year-old woman with a history of moderate persistent allergic asthma has benefited from a first desensitization protocol at age 3 .
|
[
{
"entity_text": "moderate persistent allergic asthma",
"type": "CLINENTITY"
}
] |
The protocol has been interrupted 4 years later because of a mild skin reaction .
|
[] |
Her doctor decided to stop the specific immunotherapy .
|
[] |
But another doctor restarted a new protocol of desensitization at age 16 against pollens because of a lack of control of his condition .
|
[] |
She was never hospitalized , she was receiving no medication and she was doing well one year after she received a new regimen of pneumallergens ( Alustal ® Stallergenes SA , France ) .
|
[] |
Indeed , 12 hours after initiation of treatment , she complained of abdominal pain , vomiting and diarrhea without fever .
|
[
{
"entity_text": "abdominal pain",
"type": "CLINENTITY"
},
{
"entity_text": "vomiting",
"type": "CLINENTITY"
},
{
"entity_text": "diarrhea",
"type": "CLINENTITY"
}
] |
Several hours after , she consulted to the emergency department where a surgical emergency was ruled out .
|
[] |
She was then admitted to the internal medicine ward .
|
[] |
Two days later , she developed an acute respiratory failure and was referred to the intensive care unit where laboratory tests revealed multiorgan failure : liver enzymes , 5000 U / L ( normal level , 0 -37 U / L ) ; creatine phosphokinase , 59000 U / L ( normal level , 10 -200 U / L ) ; cardiac troponin T , 21 ng / ml ( normal level , under 0 , 01 ng / ml ) ; leucopenia , 2600 / mm 3 ( normal level , 4000-9000 / mm 3 ) ; thrombocytopenia , 13000 / mm 3 ( normal level , 150000-400000 / mm 3 ) ; prothrombin time , 38 % ( normal level , 70-100 % ) .
|
[
{
"entity_text": "acute respiratory failure",
"type": "CLINENTITY"
},
{
"entity_text": "multiorgan failure",
"type": "CLINENTITY"
}
] |
Chest X-ray demonstrated bilateral interstitial markings with a normal cardiac silhouette .
|
[
{
"entity_text": "interstitial markings",
"type": "CLINENTITY"
}
] |
Viral serology was normal for hepatitis A , B , C , D , and E , Epstein-Barr virus and Cytomegalovirus .
|
[] |
A skin morbilliform rash and facial edema appeared later .
|
[
{
"entity_text": "skin morbilliform rash",
"type": "CLINENTITY"
},
{
"entity_text": "facial edema",
"type": "CLINENTITY"
}
] |
The patient received a fluid resuscitation , platelet and erythrocyte transfusion , steroids and antibiotics .
|
[] |
A hypoxic coma occurred on day 4 leading to intubation and mechanical ventilation .
|
[
{
"entity_text": "hypoxic coma",
"type": "CLINENTITY"
}
] |
Rapidly , she experienced intractable shock and acute renal impairment despite inotropic agents leading to death on day 5 .
|
[
{
"entity_text": "shock",
"type": "CLINENTITY"
},
{
"entity_text": "acute renal impairment",
"type": "CLINENTITY"
}
] |
Here , we present a case of unicentric Castleman ' s disease in a 37 - year-old woman without associated neoplastic , autoimmune or infectious diseases .
|
[
{
"entity_text": "Castleman ' s disease",
"type": "CLINENTITY"
},
{
"entity_text": "neoplastic , autoimmune or infectious diseases",
"type": "CLINENTITY"
}
] |
The lesion was located in the femoral region of the right lower extremity and surgically resected after radiographic workup and excisional biopsy examinations .
|
[
{
"entity_text": "lesion",
"type": "CLINENTITY"
}
] |
The tumor comprised lymphoid tissue with numerous germinal centers with central fibrosis , onion-skinning and rich interfollicular vascularization .
|
[
{
"entity_text": "tumor",
"type": "CLINENTITY"
},
{
"entity_text": "lymphoid tissue",
"type": "CLINENTITY"
},
{
"entity_text": "fibrosis",
"type": "CLINENTITY"
},
{
"entity_text": "onion-skinning",
"type": "CLINENTITY"
}
] |
CD 23 - positive follicular dendritic cells were detected in the germinal centers and numerous CD 138 - positive plasma cells in interfollicular areas .
|
[
{
"entity_text": "CD 23 - positive follicular dendritic cells",
"type": "CLINENTITY"
}
] |
The diagnosis of mixed cellularity type Castleman ' s disease was established and the patient recovered well .
|
[
{
"entity_text": "Castleman ' s disease",
"type": "CLINENTITY"
}
] |
An eleven year old girl presented to the paediatric eye clinic of the University College Hospital , Ibadan , Nigeria with a history of squint and poor vision .
|
[
{
"entity_text": "poor vision",
"type": "CLINENTITY"
}
] |
Her mother had noticed a misalignment of the eyes three years previously and the patient had been complaining about poor distance vision for about a year .
|
[
{
"entity_text": "poor distance vision",
"type": "CLINENTITY"
}
] |
There was no history of antecedent trauma to the head or face .
|
[] |
There was no history of double vision ( diplopia ) or pains on ocular movements .
|
[
{
"entity_text": "double vision",
"type": "CLINENTITY"
},
{
"entity_text": "diplopia",
"type": "CLINENTITY"
}
] |
There was no associated headache , fever , vomiting , joint pains or skin rashes / lesions .
|
[
{
"entity_text": "headache",
"type": "CLINENTITY"
},
{
"entity_text": "fever",
"type": "CLINENTITY"
},
{
"entity_text": "vomiting",
"type": "CLINENTITY"
},
{
"entity_text": "skin rashes / lesions",
"type": "CLINENTITY"
}
] |
The review of systems was essentially normal and she had enjoyed good health since early childhood .
|
[] |
Her pregnancy and delivery were uneventful ; and her development was normal .
|
[] |
All other family members were well and there was no family history of squint .
|
[
{
"entity_text": "squint",
"type": "CLINENTITY"
}
] |
Unaided visual acuity was 6 / 24 in the right eye and counting fingers ( CF ) in the left eye .
|
[] |
During refraction , her visual acuity improved to 6 / 9 and 6 / 60 in the right and left eyes respectively .
|
[] |
The refractive error was a hypermetropia of + 4 . 50 diopters in each eye .
|
[
{
"entity_text": "hypermetropia",
"type": "CLINENTITY"
}
] |
Examination revealed normal anterior and posterior segments bilaterally .
|
[] |
There was about 10 prism diopters of left hypotropia with no horizontal deviation in the primary position and she did not have an abnormal head posture .
|
[
{
"entity_text": "hypotropia",
"type": "CLINENTITY"
}
] |
Her palpebral fissures were normal and equal on both sides in the primary position of gaze .
|
[] |
Examination of the ocular motility elicited marked limitation of elevation of the left eye when looking to the right , while elevation of the same eye was almost full on left gaze .
|
[] |
The movements of the right eye were normal and there were no significant changes in the palpebral fissures of both eyes during eye movements .
|
[] |
Forced duction test ( performed under sedation ) was positive and revealed marked restriction of passive elevation of the left eye in adduction .
|
[] |
Her systemic examination was completely normal .
|
[] |
A diagnosis of congenital left Brown syndrome with severe amblyopia was made .
|
[
{
"entity_text": "congenital left Brown syndrome",
"type": "CLINENTITY"
},
{
"entity_text": "amblyopia",
"type": "CLINENTITY"
}
] |
Spectacles were prescribed and she was commenced on a trial of amblyopia therapy which consisted of patching of the right eye for a period of 3-4 hours every day ( after school ) .
|
[] |
Her mother was counselled and educated about the condition as well as the treatment plan .
|
[] |
Specifically , she was informed that surgery was necessary to correct the squint , irrespective of the outcome of the amblyopia therapy .
|
[
{
"entity_text": "squint",
"type": "CLINENTITY"
}
] |
A three month follow up visit was scheduled , however , the patient defaulted after the initial visit .
|
[] |
A 64 - year-old woman was admitted to our institution with palpable lump in her left breast .
|
[
{
"entity_text": "palpable lump",
"type": "CLINENTITY"
}
] |
Patient had not any previous medical and family story of cancer and denied any use of alcohol and cigarettes .
|
[
{
"entity_text": "cancer",
"type": "CLINENTITY"
}
] |
She took oral contraception for 5 years .
|
[] |
Her menarche was at age 12 .
|
[] |
Physical examination revealed a 3 cm tumor located on the left breast adhere to deep plans .
|
[
{
"entity_text": "tumor",
"type": "CLINENTITY"
}
] |
There was no retraction of the nipple , skin ulceration or inflammatory changes .
|
[
{
"entity_text": "retraction of the nipple",
"type": "CLINENTITY"
},
{
"entity_text": "skin ulceration",
"type": "CLINENTITY"
}
] |
The right breast exam was negative and there was no clinical evidence of axillary lymph node involvement .
|
[] |
Mammography revealed a 2 . 6 cm round hyperdense mass with irregular and speculated margins in the subareolar area with associated microcalcifications within the mass .
|
[
{
"entity_text": "microcalcifications",
"type": "CLINENTITY"
}
] |
The mass was categorized as Breast Imaging Reporting and Data System category 5 .
|
[] |
Fine needle aspiration and a core biopsy of the lesion were performed and the diagnostic was tubular carcinoma of the breast .
|
[
{
"entity_text": "tubular carcinoma of the breast",
"type": "CLINENTITY"
}
] |
The patient underwent left lumpectomy with axillary node dissection .
|
[] |
The macroscopic ( gross ) examination of specimens revealed the presence of a nodule measuring 1 . 5 cm in its largest diameter .
|
[
{
"entity_text": "nodule",
"type": "CLINENTITY"
}
] |
The histology showed that tumor cells were arranged in a rare trabecular pattern with a prominent lymphoid stroma .
|
[
{
"entity_text": "trabecular pattern",
"type": "CLINENTITY"
}
] |
Carcinomatous cells were polygonal with granular amphophilic cytoplasm and a nucleus with fine chromatin .
|
[] |
Nucleoli were generally inconspicuous .
|
[] |
Up to 8 mitoses per 10 HPF were counted .
|
[] |
No lympho-vascular component or intraductal component was noted .
|
[] |
The tumor was grade II of Scarf Bloom Richardson .
|
[
{
"entity_text": "tumor",
"type": "CLINENTITY"
}
] |
Surgical margin was clear .
|
[] |
The resected axillary lymph nodes contained metastases , including one / 19 N level I lymph nodes .
|
[
{
"entity_text": "metastases",
"type": "CLINENTITY"
}
] |
The immunohistochemistry study showed an expression of the following antibodies Ck ( AE 1 / AE 3 ) on the carcinomatous component , CD 3 and CD 20 with homogenous distribution in the stroma .
|
[] |
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