0 stringlengths 12 494 | embeddings listlengths 384 384 |
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in\tfoods\tthat\ttrigger\tadverse\timmunologic\treactions;\tmost\toften\tare\nspecific\tproteins,\tglycoprotein,\tor\thaptens\tthat\tcan\tinteract\twith\tthe\tbody’s\timmune\tcells\tin\ta\nway\tthat\tleads\tto\tdevelopment\tof\ta\tfood\tallergy\n•\t\nAtopy:\n\ta\tcondition\tof\tgenetic\tpredisposition\tto\tproduce\texc... | [
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0.034518677... |
an\tallergen\tthat\tresults\tin\tthe\tdevelopment\tof\ttypical\tsymptoms\tsuch\tas\tasthma,\trhinitis,\nconjunctivitis,\tor\teczema\n•\t\nCross-reactivity:\n\twhen\tan\tantibody\treacts\tnot\tonly\twith\tthe\toriginal\tallergen\tbut\talso\twith\ta\nsimilar\tallergen;\toccurs\twhen\ta\tfood\tallergen\tshares\tstructural... | [
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0.05725... |
different\tfood\tallergen\tor\taeroallergen\t(i.e.,\ta\tpollen),\twhich\tmay\tthen\ttrigger\tan\tadverse\treaction\nsimilar\tto\tthat\ttriggered\tby\tthe\toriginal\tfood\tallergen;\tcross-reactivity\tis\tcommon,\n\tfor\texample,\namong\tdifferent\tshellfish\tand\tdifferent\ttree\tnuts,\tand\tin\tpollen-food\tallergy\ts... | [
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0.0157... |
•\t\nDesensitization:\n\ta\tstate\tof\tclinical\tand\timmunologic\tnonresponsiveness\tto\ta\tfood\tallergen\tthat\ncan\tbe\tinduced\tby\tcareful,\tmedical-guided\tadministration\tof\tgradually\tincreasing\tamounts\tof\tthe\nallergen\tover\ta\tshort\tperiod\tof\ttime\t(hours\tto\tdays);\tthe\tmaintenance\tof\tsuch\tdese... | [
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0.03413... |
usually\n\trequires\tcontinued\tregular\texposure\tto\tthe\tallergen\n•\t\nDual-allergen\texposure:\n\thypothesis\tthat\tenvironmental\texposure\tto\tfood\tallergens\tthrough\tthe\nskin\tor\texposure\tto\tairborne\tparticles\tearly\tin\tlife\tcan\tlead\tto\tsensitization\tand\tallergy,\tand\tthat | [
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0.0100121... |
the\toral\tconsumption\tof\tthese\tsame\tfoods\tduring\ta\tdevelopmentally\tappropriate\tperiod,\talso\tearly\nin\tlife,\tresults\tin\ttolerance\n•\t\nFood\tallergy:\n\tan\n\tadverse\timmune-mediated\treaction\tto\ta\tfood,\tusually\ta\tfood\tprotein\tor\tspecific\nglycoprotein\tthat\tthe\tperson\thas\tbeen\tsensitized... | [
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0.027973... |
inflammatory\tmediators\tor\tchemicals\tthat\tact\ton\tbody\ttissues\tand\tresult\tin\tsymptoms.\tThe\nreaction\tcan\tbe\teither\tIgE-mediated\tor\tnon–IgE-mediated\tand\toccurs\treproducibly\tupon\texposure\nto\tthat\tfood\n•\t\nFood\tautoimmune\tor\timmune\n\treactivity:\n\tthe\tconcept\tthat\twhen\tthe\tbody’s\tnorm... | [
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0.0647420... |
reactivity:\n\tthe\tconcept\tthat\twhen\tthe\tbody’s\tnormal\ttolerance\nof\tfriendly\tantigenic\tsubstances\t(autoantigens\tproduced\tby\tan\tindividual’s\tbody)\tis\tdisrupted\nbecause\tof\tdisease,\tinjury,\tshock,\ttrauma,\tsurgery,\tdrugs,\tblood\ttransfusion,\tor\tenvironmental | [
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0.0768... |
triggers,\tthe\tingestion\tof\tfoods\tcontaining\tantigenic\tsubstances\twith\ta\tcomposition\tsimilar\tto\nthose\tof\tthe\tbody’s\tautoantigens\tcan\tresult\tin\tthe\n\tproduction\tof\tantibodies\tthat\treact\tto\tthe\tfood\nantigens\tand\tthe\tbody’s\town\ttissues\t(Vojdani,\t2015)\n•\t\nFood\tintolerance:\n\tan\tadv... | [
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-0.0344... |
immunologic\tpathophysiology\n•\t\nFood\tsensitivity:\n\ta\tterm\toften\tused\tto\tdescribe\ta\treaction\twhen\tit\tis\tunclear\twhether\tit\tis\nimmunologically\tmediated\tor\tnot\n•\t\nOral\ttolerance:\n\tthe\tprocess\tthat\tallows\tan\tindividual\n\tto\teat\tfood\tthat\tis\t“foreign”\twithout\tany\till\neffects\tor\... | [
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0.01662583090364933,
0.10391024... |
effects\tor\treactions\tto\tit\n•\t\nSensitivity-related\tillness:\n\tthe\tconcept\tthat\tan\tindividual\twho\tis\texposed\tto\tsome\ttype\tof\ntoxicant\tor\tinsult\tmay\tthen,\tby\tas\tyet\tunclear\tmechanisms,\tbecome\tsensitive\tto\ta\tfood,\tinhalant,\nor\tchemical\t(Genuis,\t2010) | [
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0.06190... |
or\tchemical\t(Genuis,\t2010)\nSource:\tIOM\tGlobal\tReport:\tFinding\ta\tPath\tto\tSafety\tin\tFood\tAllergy:\tAssessment\tof\tthe\tGlobal\tBurden,\tCauses,\nPrevention,\tManagement\tand\tPublic\tPolicy.\nPrevalence\nThere\tis\tevidence\tthat\tadverse\tfood\treactions\tare\tmore\tprevalent\tthan\tin\tthe\tpast,\twith\... | [
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0.0381236... |
increase\tin\tfood\tallergies\tin\trecent\tdecades.\tIt\tis\testimated\tthat\t10.8%\tof\tU.S.\tadults\thave\tat\tleast\tone\nfood\tallergy,\tas\tevidenced\tfrom\tsymptoms\ttypical\tof\tan\tIgE-mediated\treaction.\tBut\tonly\tabout\thalf\tof\nthose\tfood\tallergic\tadults\n\thave\tbeen\tdiagnosed\tby\ta\tphysician.\tOf\... | [
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0.003775880... |
19%\tbelieve\tthey\thave\ta\tfood\tallergy\t(\nGupta\tet\tal,\t2019\n).\tIn\tAustralia\tit\tmay\tbe\tas\thigh\tas\t10%\t(\nRenz\tet\nal,\t2018\n).\tThere\tare\talso\tdocumented\tworldwide\tincreases\tin\tfood\tallergy\tin\trapidly\temerging\tareas\tof\nAsia,\tsuch\tas\tChina.\tEstimates\tsuggest\tthat\t20%\tof\tthe\tpo... | [
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0.044316451... |
adverse\tfood\n\treactions\t(\nTurnbull\tet\tal,\t2015\n).\nHowever,\tthere\tare\tgaps\tin\tthe\tprecise\tprevalence\tof\tadverse\tfood\treactions\tdue\tto\tmisuse\tof\tthe\tterms\n“food\tallergy”\tand\t“food\tintolerance,”\tvariations\tin\tstudy\tdesign\tand\tmethodologies,\tand\tinflated\tself- | [
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0.011389805004000664,
0.10319708287715912,
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0.018942920491099358,
-0.0012... |
reporting.\tGeographic\tvariations;\tdiet\texposure\teffects;\tdifferences\tin\tage,\trace,\tand\tethnicity;\tand\tother\nfactors\talso\tcomplicate\tdata\treporting.\tDespite\n\tthe\tlack\tof\tprecise\tprevalence\tdata,\tthere\tis\tagreement\nthat\tchanges\tin\tdiet,\tlifestyle,\tand\tenvironmental\tinfluences,\tintera... | [
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0.08874230086803436,
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0.0557931624352932,
0.047... |
microbiome\talterations,\tcan\tbe\timplicated\tin\tthe\tescalation\tof\tadverse\tfood\treactions\tand\tthe\tparallel\trise\nin\tother\tchronic\tdisorders\tsuch\tas\tasthma\tand\tautoimmune\tdiseases\t(\nSicherer\tand\tSampson,\t2018\n;\nNASEM,\t2017\n).\nEtiology\nAdverse\n\tfood\treactions\tillustrate\tthe\tcritical\t... | [
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0.07... |
core\tclinical\tconcept\tin\tnutrition\tassessment.\tNumerous\tfactors\thave\tbeen\tidentified\tthat\tplay\ta\trole\tin\ninfluencing\timmune-\tand\tnonimmune-mediated\tresponses\tto\tfood\tor\tfood\tcomponents\tand\ttheir\tultimate\ninterpretation\tby\tthe\tbody\tas\teither\t“friend”\tor\t“foe,”\tincluding:\nIndividual... | [
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0.005811709... |
Individual\tFactors\nAge\nGenetics\tand\tepigenetics\nEarly\tlife\tfactors\t(maternal\tnutrition,\tbirth\tdelivery\tmethod,\tbreast\tor\tformula\tfeeding)\nImmunocompetence\tand\tpersonal\tdifferences\tin\timmune\tfunction\nIntestinal\tand\tskin\tbarrier\tdefects\nMicrobiome\nIncreased\thygiene\nUse\tof\tmedications\t(... | [
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0.05304865... |
Underlying\tdisease\nPresence\tof\tchronic\tstress\nEnvironmental\tinfluences\n\t(toxin\tand\tchemical\texposures\tsometimes\treferred\tto\tas\tthe\texposome)\nFood-related\tfactors\nModern\twesternized\tdiet\nPrenatal\tperinatal,\tand\tmaternal\tnutrition\nAllergen\ttype,\tdose,\tand\troute\tof\texposure\nMicrobial\tp... | [
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0.059... |
Microbial\tproducts\tand\tcontamination\twith\tmicroorganisms\nFood\tmatrix\t(proteins,\tlipids,\tand\tglycosylated\tsugars)\nCooking\ttemperature\nEpithelial\tbarrier\tinsulting\tagent\t(alcohol,\tadditives,\n\ttoxins,\tunknown\tingredients)\t(\nSampson\tet\tal,\n2018\n).\nGenetics\tand\tepigenetics | [
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0.106991... |
Sampson\tet\tal,\n2018\n).\nGenetics\tand\tepigenetics\nIt\thas\tbeen\trecognized\tfor\tmore\tthan\ta\tcentury\tthat\tgenetics\tplays\ta\trole\tin\tallergies\tand\tasthma.\tFamilial\naggregations\tand\theritability\testimates\tfrom\ttwin\tstudies\tprovide\tinitial\tevidence\tfor\tgenetic | [
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predisposition\tfor\tfood\tallergy,\talthough\tamong\tsiblings,\tan\tincreased\trate\tof\tsensitization\tdoes\tnot\nequate\tto\n\tclinical\treactivity.\tA\tnumber\tof\tmonogenic\tdisorders\tassociated\twith\tatopy\tand\tfood\tallergy\nhave\tbeen\tidentified;\thowever,\tthe\tgenetics\tof\tfood\tallergy\thave\tshifted\tf... | [
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0.0256287... |
or\tpolymorphism\tin\ta\tgene\tto\tthe\tinclusion\tof\ta\tmultitude\tof\tcontributing\tgenetic\tand\tnongenetic\trisk\nfactors\t(\nCarter\tand\tFrischmeyer-Guerrerio,\t2018\n).\nGenetic\tmechanisms\tthat\tplay\ta\trole\tin\tpathogenesis\n\tof\tfood\tallergy\tare\tmultifactorial\tand\tcomplex.\tThe | [
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0.0389... |
of\tfood\tallergy\tare\tmultifactorial\tand\tcomplex.\tThe\nexpression\tof\tfood\tallergy\tis\tinfluenced\tby\tthe\tenvironment,\tgene-environment\tinteractions,\tand\nepigenetic\n\tmodification\tof\tthe\tgenome\t(“epigenome”).\tThe\tepigenome\tis\tlargely\testablished\tin\tutero\tand\nis\trelevant\tto\tearly\tlife\tor... | [
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0.00... |
NASEM,\t2017\n;\t\nCarter\tand\tFrischmeyer-Guerrerio, | [
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-0.01750473864376545,
0.0445... |
2018\n).\nMore\trecently,\tgenome\twide\tassociation\n\tstudies\t(GWASs)\tidentified\tgenes\tassociated\twith\tfood\nallergies.\tOne\tGWAS\tstudy\texamined\t1500\tchildren\twith\tfood\tallergies\tin\tGermany\tand\tthe\tUnited\tStates.\nThis\tstudy\texamined\tmore\tthan\tfive\tmillion\tgenetic\tvariations\tor\tsingle\tn... | [
-0.03977635130286217,
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0.03863613307476044,
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0.03033444657921791,
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0.08228825032711029,
0.1534528136253357,
-0.06947151571512222,
-0.04443734884262085,
0.010938... |
in\teach\tchild\tin\tthe\tstudy\tand\tcompared\tthe\tfrequency\tof\tthese\tSNPs\twith\tthe\tcontrol\tsubjects.\tIn\naddition\tto\tthe\tlarge\tnumber\tof\tsubjects,\n\tunlike\tother\tstudies,\tthe\tresearchers\talso\tincluded\tan\toral\tfood\nchallenge\tto\tconfirm\tthe\tallergy\tdiagnosis.\tThe\tstudy\tidentified\tfive... | [
0.02488287352025509,
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0.06699583679437637,
0.12955796718597412,
-0.01841103844344616,
0.05867849662899971,
0.02366... |
and\tfour\tof\tthem\tshowed\ta\tstrong\tassociation\twith\tloci\tfor\t\natopic\tdermatitis\n\t(hereditary\teczematous\nrash),\tasthma,\tand\tother\tchronic\tinflammatory\tand\tautoimmune\tdiseases.\tThe\t\nSERPINB\n\tgene\tcluster\ton\nchromosome\t18\twas\tpinpointed\n\tas\ta\tspecific\tgenetic\trisk\tlocus\tfor\tfood\... | [
-0.008770700544118881,
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0.05093035101890564,
-0.03908854350447655,
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0.06500684469938278,
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0.0985737293958664,
0.132236510515213,
-0.07832001894712448,
0.01393959391862154,
0.030818... |
particular\tcluster\tare\texpressed\tin\tthe\tskin\tand\tmucous\tmembrane\tof\tthe\tesophagus,\twhich\tare\tinvolved\nin\tmaintaining\tepithelial\tbarrier\tintegrity\t(\nMarenholz\tet\tal,\t2017\n).\nAnother\tGWAS\tstudy\tincluded\ta\tmeta-analysis\tof\ttwo\tphenotypes,\tpeanut\tallergy\tand\tfood\tallergy,\tand\nexami... | [
0.008711136877536774,
0.0016950914869084954,
0.07163961976766586,
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0.060651592910289764,
0.00005711284029530361,
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0.03995414450764656,
0.10106021165847778,
-0.10169550776481628,
-0.01609349064528942,
... |
examined\tseven\tstudies\tfrom\tCanadian,\tAmerican,\tAustralian,\n\tGerman,\tand\tDutch\tpopulations.\tMultiple\ngenes\twere\tidentified\tas\trisk\tfactors\tfor\tpeanut\tallergy\tand\tfood\tallergy\tand\tare\tinvolved\tin\tepigenetic\nregulation\tof\tgene\texpression\t(\nAsai\tet\tal,\t2018\n). | [
0.025844363495707512,
0.028571635484695435,
0.061113521456718445,
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0.02853657864034176,
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0.09620088338851929,
0.12293669581413269,
-0.10363765060901642,
-0.030101610347628593,
0.0... |
regulation\tof\tgene\texpression\t(\nAsai\tet\tal,\t2018\n).\nUnlike\tother\tdiseases,\tthe\tnumber\tof\tidentified\tloci\tfor\tfood\tallergies\tis\trelatively\tsmall.\tMost\tof\tthe\nidentified\tcandidate\tgenes\tencode\tfor\tproducts\tinfluencing\timmune\tmechanisms\ttoward\ta\tTh2\ninflammatory | [
0.02657260186970234,
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0.003024652600288391,
-0.05146922916173935,
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0.03589528799057007,
0.07376883924007416,
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0.01683337427675724,
0.08137691766023636,
0.09017665684223175,
-0.0790681540966034,
0.03688596561551094,
0.06128196... |
inflammatory\n\tshift.\tIt\tis\thypothesized\tthat\tgenetic\tpredispositions\tin\tthe\tcontext\tof\tcertain\tenvironmental\ninfluences\tsuch\tas\tintestinal\tviral\tinfection\tmay\tresult\tin\timmune\tsystem\tdysfunction\tand\tresult\tin\tfood\nallergy\t(\nNASEM,\t2017\n).\t(See\t\nChapters\t6\n\tand\t\n7\n).\nPathophy... | [
0.03818351775407791,
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0.07022769749164581,
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0.06907733529806137,
0.09875710308551788,
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0.12437938153743744,
0.06767730414867401,
-0.03203887492418289,
0.016958408057689667,
0.0787622556... |
).\t(See\t\nChapters\t6\n\tand\t\n7\n).\nPathophysiology\tof\tfood\tallergy\nMajor\tadvances\tin\tresearch\tare\tproviding\tfurther\tinsights\tinto\tthe\tmechanisms\tleading\tto\tfood\tallergies.\nA\tbasic\n\tunderstanding\tof\tthe\timmune\tsystem\tis\tessential\tsince\tthe\tmechanisms\tentail\tmultiple\tmolecules\ninv... | [
0.014729422517120838,
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0.06137201189994812,
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0.014931757934391499,
0.05168183520436287,
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0.13540717959403992,
0.10040625184774399,
-0.050049059092998505,
-0.010172070004045963,
0.05... |
involved\tin\timmune\tregulation.\nImmune\tsystem\tbasics\nAntibodies\n\tare\tspecialized\timmune\tproteins\tthat\tare\tproduced\tin\tresponse\tto\tthe\tintroduction\tof\tan\nantigen\n\t(an\t\nallergen\n,\ttoxin,\tor\tforeign\tsubstance)\tinto\tthe\tbody.\tBecause\tof\ttheir\tassociation\twith\tthe\nimmune\tsystem,\tan... | [
-0.011598010547459126,
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0.05788622051477432,
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0.05649125576019287,
0.08196400851011276,
0.011281999759376049,
0.026324355974793434,
0.09628640860319138,
0.10346358269453049,
-0.04487328231334686,
0.004331558011472225,
0.0417419... |
immune\tsystem,\tantibodies\tare\treferred\tto\n\tas\t\nimmunoglobulins\t(Ig)\n.\tFive\tdistinct\tclasses\tof\tantibodies\nhave\tbeen\tidentified:\tIgA,\tIgD,\tIgE,\tIgG,\tand\tIgM.\tEach\tIg\thas\ta\tspecific\tfunction\tin\timmune-mediated\nreactions\t(\nBox\t25.2\n).\nBOX\t25.2\nThe\tImmunoglobulins\nIgA | [
-0.005232503172010183,
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0.0363360233604908,
-0.023059062659740448,
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0.025235826149582863,
0.13476410508155823,
0.04511180892586708,
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0.10234285891056061,
0.057506319135427475,
-0.0582568384706974,
0.019432058557868004,
0.066160... |
reactions\t(\nBox\t25.2\n).\nBOX\t25.2\nThe\tImmunoglobulins\nIgA\nFound\tin\ttwo\tforms—serum\tIgA\tand\tsecretory\tIgA\t(sIgA).\tThe\tlatter\tis\tpresent\tin\tmucus\tsecretions\tin\nthe\tmouth,\trespiratory\tand\tgastrointestinal\ttracts,\tvagina,\tand\tcolostrum\n\tin\tmammalian\tmilk.\tIt | [
-0.014099758118391037,
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0.009044135920703411,
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0.0504559651017189,
0.08613994717597961,
0.06502234935760498,
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0.09534425288438797,
0.07049422711133957,
-0.1062382385134697,
-0.02640412375330925,
0.0792856... |
in\tmammalian\tmilk.\tIt\nincludes\ta\t“secretory\tpiece”\tin\tits\tstructure\tthat\tprotects\tit\tfrom\tprotein-destroying\tenzymes\tin\tthe\ndigestive\ttract\tso\tthat\tit\tsurvives\tin\tan\tactive\tform\tas\ta\t“first-line”\tdefense\tagainst\tantigens\tentering\nfrom\tthe\texternal\tenvironment.\tSerum\tIgA,\twhich\... | [
0.03521633520722389,
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0.07101792842149734,
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0.09952189773321152,
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0.09614028036594391,
0.06152098625898361,
-0.05003409460186958,
0.035758208483457565,
0.014... |
highest\tamount\tin\tcirculation,\texceeded\tonly\tby\tIgG.\nIgD\nFound\tin\n\tsmall\tamounts\tin\tthe\ttissues\tthat\tline\tthe\tbelly\tand\tchest;\tinvolved\tin\timmunoglobulin\tclass\nswitching.\tSignals\tB\tcells\tto\tbe\tactivated.\tSuggestion\tthat\tIgD-producing\tB\tcells\tare\tauto\treactive | [
0.007179467938840389,
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0.038022469729185104,
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0.10841445624828339,
0.03444022312760353,
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0.06562449038028717,
0.05823180824518204,
-0.030393296852707863,
0.05962396413087845,
0.0026... |
lymphocytes\tand\tmay\tbe\tinvolved\tin\tautoimmune\tdisease.\tIts\trole\tin\tallergy\tis\tprobably\tminimal.\nIgE\nThe\tclassic\tallergy\tantibody\tof\thay\tfever,\tasthma,\teczema,\tfood-induced\tallergy,\tfood-induced\nanaphylaxis,\n\tpollen-food\tallergy\tsyndrome\t(PFAS),\tand\tlatex-fruit\tallergy.\tImmediate\tal... | [
0.024735325947403908,
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0.030335867777466774,
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0.07526491582393646,
0.04761790111660957,
0.07602360099554062,
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0.0922711044549942,
0.12325379252433777,
-0.01014801301062107,
0.03718798607587814,
0.000252... |
usually\tinvolve\tIgE\tand\tare\tthe\tmost\tclearly\tunderstood\tmechanisms.\nIgG\nThe\tonly\tantibody\tthat\tcrosses\tthe\tplacenta\tfrom\tmother\tto\tbaby\tand\tis\tthe\tmost\tcommon\tantibody\nin\tthe\tblood.\tDefends\tagainst\tpathogens\tand\tpersists\tlong\tafter\tthe\tthreat\tis\tover.\tFour\tsubtypes\ninclude\tI... | [
0.022699082270264626,
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0.0472332127392292,
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0.06185951456427574,
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0.07160670310258865,
0.06529280543327332,
-0.04289553314447403,
0.026860296726226807,
-0.010... |
include\tIgG1,\tIgG2,\tIgG3,\tand\tIgG4.\tFood\n\tprotein–specific\tIgG\tantibodies\ttend\tto\trise\tin\tthe\tfirst\tfew\nmonths\tafter\tthe\tintroduction\tof\ta\tfood\tand\tthen\tdecreases\teven\tthough\tthe\tfood\tmay\tcontinue\tto\tbe\nconsumed.\tIt\tappears\tto\tbe\tpart\tof\tthe\tprocess\tof\tdevelopment\tof\ttole... | [
0.0060514118522405624,
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0.036611951887607574,
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0.009209404699504375,
0.107818104326725,
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0.044071633368730545,
0.11923649907112122,
-0.05531720444560051,
0.07013746351003647,
0.0180... |
specific\tIgG4\taccompanied\tby\ta\tdrop\tin\tIgE\toften\tindicates\ttolerance\tof\tthe\tfood.\tPeople\twith\ninflammatory\tbowel\tdisorders\tsuch\tas\tuntreated\n\tceliac\tdisease\tor\tulcerative\tcolitis\toften\thave\thigh\nlevels\tof\tIgG\tand\tIgM\t(Stapel\tet\tal,\t2008),\tpossibly\tindicating\tthe\tpassage\tof\tf... | [
0.02684928849339485,
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0.04222014546394348,
-0.031131643801927567,
-0.08346109092235565,
0.005463527049869299,
0.08038657158613205,
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0.07876692712306976,
0.09572995454072952,
-0.06082095578312874,
0.03185645118355751,
0.065727... |
“foreign\tinvaders”\tinto\tcirculation.\nIgM\nThe\tlargest\tantibody,\ta\tfirst-line\tdefender\tthat\tcan\tmop\tup\tmany\tantigens\tat\tone\ttime.\tIt\tis\tproduced\nby\tthe\tfetus\tin\tutero\tand\tits\tlevel\trises\tin\tthe\tpresence\tof\tan\tin\tutero\tinfection.\nStapel\tSO,\tAsero\n\tR,\tBallmer-Weber\tBK,\tet\tal:... | [
-0.01140685100108385,
0.0013919095508754253,
0.03968937322497368,
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0.015285876579582691,
0.09835212677717209,
-0.03257513418793678,
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0.023890197277069092,
0.09076610952615738,
-0.053178854286670685,
0.004635071847587824,
0.00... |
diagnostic\ttool:\tEAACI\tTask\tForce\tReport,\t\nAllergy\n\t63:793–796,\t2008.\nThe\tproduction\tof\tantibodies\tis\ta\tmajor\tfunction\tof\tthe\timmune\tsystem\tand\tis\tcarried\tout\tby\ta\nparticular\ttype\tof\t\nlymphocyte\n\t(white\tblood\tcell).\tThere\tare\ttwo\timportant\tgroups\tof\tlymphocytes:\t\nB- | [
-0.02071714587509632,
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0.0021094074472784996,
0.0585775226354599,
0.10921333730220795,
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0.08993735164403915,
0.06358750909566879,
-0.023572765290737152,
0.011960308998823166,
0.0956... |
cells\n\tarising\tfrom\tstem\tcells\tin\tthe\tbone\tmarrow,\n\tand\t\nT-cells\n,\talso\toriginated\tfrom\tstem\tcells\tbut\tlater\ntransported\tto\tthe\tthymus\tgland\twhere\tthey\tmature,\thence\tthe\tname\tT-cells.\tMonocytes\tand\nmacrophages\tare\tprimarily\tphagocytes\tthat\tengulf\tforeign\tmaterial,\tbreak\tit\t... | [
-0.007752527482807636,
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0.026743842288851738,
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0.04295504838228226,
0.058577995747327805,
0.0622551254928112,
0.00840794201940298,
0.09877419471740723,
0.05163351818919182,
-0.022369740530848503,
0.038532376289367676,
0.045047... |
molecules\tof\tthe\tmaterial\ton\ttheir\tsurfaces,\tmaking\tthem\t\nantigen-presenting\tcells\t(APC)\n.\tThe\nantigenic\tcomponent\tdisplayed\ton\tthe\tsurface\tis\tan\t\nepitope\n\tand\tis\trecognized\tby\tT-cells.\nT-cells\tare\ta\tdiverse\tgroup\tof\tlymphocytes\twith\tseveral\tdifferent\troles\tin\tthe\timmune\tres... | [
-0.00585636543110013,
-0.09651564061641693,
0.029022525995969772,
-0.053357917815446854,
-0.07726237177848816,
0.04129696637392044,
0.07750135660171509,
0.04879928007721901,
0.016851674765348434,
0.1252589076757431,
0.06900333613157272,
-0.041136909276247025,
0.004470239859074354,
0.047566... |
different\tcircumstances,\tand\tthey\tsecrete\tdifferent\tsets\tof\t\ncytokines\n\t(chemical\tmessengers).\t\nTh\tcells\nare\thelper\tcells\tthat\tadjust\tthe\tsystem.\t\nTh1\tcells\n\tregulate\tthe\tactivities\tof\tthe\tB-cells\tto\tproduce\nantibodies\tand\tdirect\tdamage\tto\ttarget\tcells,\tresulting\tin\tthe\n\tde... | [
0.026787882670760155,
-0.07807587832212448,
0.03737762197852135,
-0.049302369356155396,
-0.0827745869755745,
0.016757704317569733,
0.11572866886854172,
0.05125301703810692,
0.0026860698126256466,
0.07777874171733856,
0.08310307562351227,
-0.08531562238931656,
0.023256352171301842,
0.034310... |
destruction\tof\tantigens.\tThis\tfunction\tis\nuseful\tin\tdefending\tagainst\tbacteria,\tviruses,\tand\tother\tpathogenic\tcells.\t\nTh2\tcells\n\tmediate\tthe\tallergic\nresponse\tby\tregulating\tthe\tproduction\tby\tB-cells\tof\tIgE\tsensitized\tto\tfood\tor\tother\tallergens.\tOther\tT-cells\nare\t\nT-regulatory\t... | [
-0.03125505894422531,
-0.03331217169761658,
0.02919725328683853,
-0.051796332001686096,
-0.03490085527300835,
0.03147311136126518,
0.07266013324260712,
0.05859823897480965,
-0.0045656063593924046,
0.10188049077987671,
0.08626013994216919,
-0.014894839376211166,
0.022924985736608505,
0.0380... |
are\t\nT-regulatory\tcells\t(T-reg\tcells)\n\tand\t\nT-suppressor\tcells\n\tthat\tregulate\tthe\timmune\tresponse\tso\tthat\nthere\tis\ttolerance\tof\tthe\tforeign\tbut\n\tsafe\tmolecule.\nAlso\tinvolved\tin\tallergic\treactions\tare\t\ngranulocytes\n,\tcells\tthat\tcontain\tintracellular\tgranules,\twhich\tact | [
0.01600239984691143,
-0.07274731248617172,
0.012517073191702366,
-0.03939877077937126,
-0.09442593157291412,
0.035978689789772034,
0.11177606880664825,
0.07542237639427185,
0.007250574417412281,
0.09478721767663956,
0.0884752869606018,
-0.026460977271199226,
0.02911854162812233,
0.07927039... |
granulocytes\n,\tcells\tthat\tcontain\tintracellular\tgranules,\twhich\tact\nas\tstorage\tdepots\tfor\tdefense\tchemicals\tor\tinflammatory\tmediators\tthat,\twhen\treleased,\tnot\tonly\tprotect\nthe\tbody\tfrom\tinvading\tpathogens\tbut\talso\tcan\tproduce\tallergic\tsymptoms.\tGranulocytes\tcalled\t\nmast\ncells\n\ta... | [
0.016948997974395752,
-0.09941579401493073,
0.01885053515434265,
-0.07794592529535294,
-0.10891600698232651,
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0.09888632595539093,
0.09486456960439682,
0.007434542756527662,
0.09311213344335556,
0.06776393204927444,
0.027987705543637276,
0.07693947106599808,
0.0693483... |
are\tlocated\tin\tthe\tlungs,\tskin,\ttongue,\tand\tlinings\tof\tthe\tnose\tand\n\tintestinal\ttract,\tand\tthose\tcalled\nbasophils\n\tare\tin\tthe\tcirculation.\tOf\timportance\tin\tnon-IgE\tmediated\tallergy\tare\t\neosinophils\n,\tanother\nform\tof\tgranulocytes\tthat\tare\tin\tblood\tand\ttissues\tand,\twhen\tstim... | [
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0.0875384658575058,
0.07578859478235245,
-0.037099044770002365,
0.028012827038764954,
0.08643414... |
cells,\tmigrate\tto\tthe\tsite\tof\tan\tallergic\treaction.\nWhen\tgranulocytes\tdegranulate\tthey\trelease\t\ninflammatory\tmediators\n,\tsuch\tas\thistamine,\tchymase,\nand\ttryptase\n\tand,\tin\tthe\tcase\tof\tmast\tcells,\tthere\tis\tde\tnovo\tsynthesis\tof\tlipid\tmetabolites\tof\tarachidonic | [
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0.09139478951692581,
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0.0847... |
acid—prostaglandins,\tleukotrienes,\tand\tplasma\tactivating\tfactor\t(PAF).\tEach\tof\tthese\tmediators\thas\ta\nspecific\teffect\ton\tlocal\ttissues\tand\tat\tother\tsites,\tresulting\tin\tthe\tsymptoms\tof\tan\tallergic\treaction—\nvasodilation,\tincreased\tvascular\tpermeability\tleading\tto\tangioedema,\tnocicepti... | [
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0.09578398615121841,
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0.011525934562087059,
0.07451720535... |
activation\n\tcausing\titchiness,\tsmooth\tmuscle\tconstriction,\tmucous\tsecretion,\tand\tacute\tdiarrhea.\nAllergic\tresponse\nThe\tpathophysiology\tof\tthe\tallergic\tresponse\tcan\tbe\tdescribed\tin\tthree\tphases:\tthe\tbreakdown\tof\toral\ntolerance,\tallergen\tsensitization,\tand\treactivity\tto\tallergens\tlead... | [
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0.02598390355706215,
0.05946... |
Breakdown\tof\toral\ttolerance.\nHumans\tare\texposed\tto\tthousands\tof\tforeign\tmolecules\tdaily\tfrom\n\tfood\tand\tthe\tenvironment.\tExposure\tto\nthese\tforeign\tmolecules\tin\tthe\tdigestive\ttract\tthrough\tingested\tsubstances\tis\tusually\tfollowed\tby\timmune\nregulation\tor\tsuppression,\tsuch\tthat\tthe\t... | [
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0.035842... |
prerequisite\tfor\tthe\tdevelopment\tof\ttolerance\tto\ta\tfood\tor\tfood\tcomponent.\t\nOral\ttolerance\n\tis\tthe\nmechanism\tby\twhich\tpotentially\tantigenic\tsubstances\n\tdo\tnot\ttrigger\tan\timmune\tresponse\tand\tis\tthe\nnormal\tphysiologic\tresponse\tto\tingested\tantigens\t(\nTordesillas\tand\tBerin,\t2018\... | [
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0.09433... |
Tordesillas\tand\tBerin,\t2018\n).\tThe\tdevelopment\tof\nimmunologic\tand\tclinical\ttolerance\tis\tthus\tcritical\tto\tpreventing\tfood\tallergies\tand\tother\tchronic\ninflammatory\tdiseases.\tOral\ttolerance\tis\tmediated\tby\tseveral\timmune\tcells,\tincluding\tAPCs\tsuch\tas\ndendritic\tcells\t(DCs)\n\tand\tmacro... | [
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-0.017945101484656334,
0.009417649358510971,
0.0721639... |
(T\nreg\n\tcells)\t(\nBauer\tet\tal,\t2015\n).\tTolerance\nis\tacquired\twith\tinnate\tand\tadaptive\timmune\tresponses\tacting\tin\ta\tcoordinated\tmanner\tto\tmount\ta\nresponse\tto\tantigen\texposure.\tIt\tis\ta\tprocess\tthat\tstarts\tin\tutero\tand\tpersists\tthroughout\tlife\t(\nRenz\tet\tal,\n2018\n). | [
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0.04398987... |
Renz\tet\tal,\n2018\n).\nThe\tgut\tmicroenvironment\tsupports\tand\tpromotes\texpansion\tof\tthe\tregulating\tactivity\tof\tT-reg\tcells\nthrough\tmultiple\tprocesses\tincluding\tthe\n\tpresence\tof\tretinoic\tacid\t(from\tvitamin\tA)\tand\tmicrobial\nmetabolites,\tsuch\tas\tshort-chain\tfatty\tacids.\tB-cells\talso\ti... | [
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0.06524153... |
B-regulatory\n(B-reg)\tcells\n\tact\tmainly\tthrough\tinterleukin-10\t(IL-10),\tan\tantiinflammatory\tcytokine\tto\treduce\tinfection\nand\tallergic\tinflammation\tand\tto\tpromote\ttolerance.\tA\tbreakdown\tin\tthe\ttolerogenic\tprocess\tleads\tto\ta\nshift\taway\tfrom\tT-reg\tcell\n\tinduction\tto\tthe\tgeneration\to... | [
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0.01564004085958004,
0.04527617... |
to\tfood\tallergens\t(\nRenz\tet\tal,\t2018\n;\t\nSampson\tet\tal,\t2018\n).\nSensitization.\nSensitization\n\tto\tfood\tantigens\tcan\ttake\tplace\tin\tthe\tgastrointestinal\ttract,\toral\tcavity,\tskin,\tand\noccasionally\tin\tthe\trespiratory\ttract\t(\nSampson\tet\tal,\t2018\n).\tGastrointestinal\t(GI)\tfunction\ti... | [
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0.12871651351451874,
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0.03634309023618698,
0.033... |
maintenance\tof\toral\ttolerance,\n\tand\tavoidance\tof\tallergic\tsensitization\tand\tallergic\tresponse,\tsince\tthe\nvast\tmajority\tof\tfood\tproteins\tare\tbroken\tdown\tby\tgastric\tacid\tand\tdigestive\tenzymes\tin\tthe\tstomach\tand\nintestine.\nRecognized\tas\tbeing\tincreasingly\tessential\tto\tthis\tfunction... | [
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0.0215934... |
microbiome\n,\tthe\tcollection\tof\tdifferent\ttypes\tof\tmicrobes\t(bacteria,\tbacteriophage,\tfungi,\tprotozoa,\tand\nviruses)\tthat\tlive\tinside\tthe\tgut.\tThe\tintestinal\tmicrobiome\tis\tresponsible\tfor\tregulating\tthe\texpansion\tof\nT-reg\tcells\tand\tTh1\tand\tTh2\ttype\tcells\tto\tpromote\timmune\tbalance.... | [
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0.08497321605682373,
0.12199025601148605,
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0.0415559783577919,
0.09918863... |
Russler-Germain\tet\tal,\t2017\n).\nDysbiosis\n\toccurs\twhen\tthere\tis\tan\timbalance\tin\tthe\tmicrobial\tecosystem,\twhich\tcan\tcontribute\tto\nincreased\tintestinal\tpermeability\tor\t“leaky\tgut,”\n\tand\tthe\tincreased\tlikelihood\tthat\tintact\tfood\nproteins\tand\tpeptides\twill\tpass\tthrough\tthe\tintestina... | [
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0.06125813350081444,
0.07994549721479416,
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0.02103390172123909,
0.00949... |
immune\tsensitization\tand\tpossibly\treactivity\t(\nPlunkett\tand\tNagler,\t2017\n).\tThe\t\ngut-associated\tlymphoid\ntissue\t(GALT)\n\tis\tthe\tlargest\tmass\tof\tlymphoid\ttissue\tin\tthe\tbody\tand\tantigen\tpenetration\tand\npresentation\tto\tthe\tGALT\tdrives\tfood\tsensitization\t(\nFritscher-Ravens\tet\tal,\t2... | [
0.014838581904768944,
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0.052813634276390076,
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0.04357440024614334,
0.11682802438735962,
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0.0656423568725586,
0.11464650928974152,
-0.04636006057262421,
0.011217632330954075,
0.0506... |
Fritscher-Ravens\tet\tal,\t2014\n).\tOther\tconditions\n\tsuch\nas\tGI\tdisease,\tmalnutrition,\tfetal\tprematurity,\tand\timmunodeficiency\talso\tmay\tbe\tassociated\twith\nincreased\tgut\tpermeability\tand\trisk\tof\tdevelopment\tof\tfood\tallergy.\tDisruptions\tin\tthe\tmicrobiome\tand | [
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0.09158913791179657,
0.12069352716207504,
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0.004917364101856947,
0.05... |
the\tintestinal\twall\tbarrier\tare\tthe\tresult\tof\tvarious\tfactors,\tincluding\tcesarean\tdelivery,\tformula\tfeeding,\nantibiotics,\tchronic\tstress,\tinfections,\tand\talterations\tin\tthe\tmicrobiome\tdue\tto\tdisease\n\t(see\t\nChapters\t1\nand\t\n27\n\tfor\tfurther\tdiscussion\tof\tthe\tmicrobiome). | [
0.027340872213244438,
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0.03608549013733864,
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0.012640782631933689,
0.053288526833057404,
0.008830700069665909,
0.02237478829920292,
0.08022961020469666,
0.11103490740060806,
-0.07295536994934082,
0.036716658622026443,
0.0909711... |
(see\t\nChapters\t1\nand\t\n27\n\tfor\tfurther\tdiscussion\tof\tthe\tmicrobiome).\nAdditional\tforces\tdriving\ttolerance\tbreakdown\tand\tpotential\tsensitization\tmight\tarise\toutside\tthe\nintestine,\tas\tthere\tis\tevidence\tthat\tfood\tallergen\tentry\tcan\toccur\tthrough\tscratched,\tbroken,\tand\ninflamed\tskin... | [
0.015745406970381737,
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0.021942313760519028,
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0.06506575644016266,
0.04314925894141197,
0.020615024492144585,
0.07048100233078003,
0.08747820556163788,
-0.025191761553287506,
0.04038865491747856,
0.05110... |
inflamed\tskin\t(\nRenz\tet\tal,\t2018\n).\tLike\tthe\tgut,\tthe\tskin\tmicrobiome\tconsists\tof\tthousands\tof\tmicrobial\norganisms\tand\ttheir\tbyproducts\n\tthat\tinhabit\tthe\tskin.\tA\tharmonious\tbalance\tof\tthe\tgut-skin-microbiota\tis\nnow\tthought\tto\tbe\tvital\tto\ta\twell-functioning\timmune\tsystem. | [
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0.04682222753763199,
0.048450347036123276,
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0.10118570923805237,
0.0993877649307251,
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0.029079297557473183,
0.081836... |
Reaction.\nThe\tthird\tphase\tof\tthe\tallergic\tresponse\tis\treactivity\twhenever\tan\tallergen\tto\twhich\tthe\timmune\tsystem\tis\nnow\tsensitized\tenters\tthe\tbody\tagain.\tBecause\tindividuals\tcan\tdevelop\timmunologic\tsensitization\tas\nevidenced\tby\tthe\tproduction\tof\tallergen-specific\n\tIgE\t(sIgE)\tor\... | [
0.02969283051788807,
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0.08295561373233795,
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0.07225033640861511,
0.07409777492284775,
0.04013959318399429,
0.01991945318877697,
0.1494266837835312,
0.09511067718267441,
-0.08435631543397903,
0.005250954534858465,
0.05909243971... |
IgE\t(sIgE)\tor\tother\timmune\tcell\tsensitization\twithout\nhaving\tallergic\tsymptoms\tupon\tsubsequent\texposure\tto\tthose\tfoods,\tan\tIgE-mediated\tor\tnon–IgE-\nmediated\tfood\tallergy\trequires\tthe\tpresence\tof\tnot\tonly\tloss\tof\ttolerance\tand\tsensitization\tbut\talso\tthe\npresence\tof\tclinical\tsympt... | [
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0.10613599419593811,
0.0236910842359066,
0.035995788872241974,
0.06560972332954407,
0.11055812239646912,
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0.06822188198566437,
0.0448819... |
NASEM,\n2017\n)\t(\nFig.\t25.2\n).\nFIG.\t25.2\nSensitization\tprocess\tand\tIgE-mediated\tallergic\treaction.\nIgE-mediated\treactions\n\toccur\twhen\tsIgE\tproduced\tin\tresponse\tto\tthe\tpresence\tof\tthe\tallergen\nattaches\tto\tmatching\tsIgE\tantibodies\ton\tthe\tmast\tcell\tor\tbasophil,\tforming\ta\t“bridge”\t... | [
0.01068183220922947,
-0.03472103551030159,
0.04847796633839607,
-0.04112353175878525,
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0.014514327049255371,
0.06495121866464615,
0.011926576495170593,
0.038630012422800064,
0.0661659836769104,
0.08807872980833054,
-0.038565173745155334,
0.024402156472206116,
0.0283537... |
bridging\tactivates\tthe\tmast\tcell\tor\tbasophil\tby\ta\tseries\tof\tenergy-requiring\tprocesses\tresulting\tin\tthe\ncell’s\tdegranulation\tand\n\trelease\tof\tthe\tinflammatory\tmediators,\tand\tthe\tappearance\tof\tallergic\tsymptoms.\nIgE-mediated\tfood\tallergic\treactions\tare\trapid\tin\tonset,\toccurring\twit... | [
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0.11359703540802002,
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0.0535876527428627,
0.06407199800014496,
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0.05066756531596184,
0.0568910... |
exposure\tthrough\teither\tinhalation,\tskin\tcontact,\tor\tingestion.\tA\twide\trange\tof\tsymptoms\tare\tattributed\nto\tthis\ttype\tof\treaction,\tand\tusually\tinvolve\tthe\tGI,\tdermatologic,\tor\trespiratory\tsystems\tand\tcan\trange\nfrom\tmild\n\thives\tto\tlife-threatening\tmultiple\torgan\tanaphylaxis\t(\nFig... | [
0.02835458517074585,
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0.09346667677164078,
0.057854216545820236,
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0.06265144050121307,
0.1053178533911705,
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0.029157111421227455,
0.068... |
FIG.\t25.3\nA\n\tand\t\nB\n,\tAtopic\teczema:\tAn\tIgE-mediated\tskin\treaction\tto\ta\tfood\tallergen,\tcommonly\tseen\ton\tthe\thands,\nback\tof\tknees,\tand\tthe\tinside\tof\telbows.\n\t\nSource:\n\tA,\tFrom\t\t\nwww.istockphoto.com\n.\nNon–IgE-mediated\treactions\n\tare\tbased\ton\tthe\tactivation\tof\tcells\tother... | [
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0.027425045147538185,
-0.029955647885799408,
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-0.03231764957308769,
0.11675330251455307,
0.049669791013002396,
0.03845280781388283,
0.0713328942656517,
0.15429949760437012,
-0.015426588244736195,
0.028258031234145164,
0.05192... |
and\ttheir\tdegranulation\tand\trelease\tof\tmediators.\tNon–IgE-mediated\treactions\tare\tpresent\tin\tdelayed\n\tor\nchronic\treactions\tto\tfood\tallergen\tingestion.\tSee\t\nTable\t25.2\n\tfor\ta\tcomparison\tof\tIgE-\tand\tnon–IgE-\nmediated\tallergic\treactions. | [
0.038674984127283096,
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0.09376700222492218,
0.021816115826368332,
-0.009270425885915756,
0.07696574926376343,
0.1241740882396698,
-0.030837396159768105,
-0.01089280005544424,
0.0607... |
TABLE\t25.2\nComparison\tof\tIgE-\tand\tNon–IgE-Mediated\tAllergic\tReactions\nCharacteristics/Target\nOrgan\nIgE\tMediated\nNon–IgE-Mediated\nMixed\tIgE-\tand\nNon–IgE-\nMediated\nMechanism\nTh2\tactivation\tstimulates\nproduction\tof\tIgE\tby\tactivated\tB-\ncell\tlymphocytes.\tAllergen\tbinds\nwith\tthe\treceptors\t... | [
0.012236041948199272,
-0.10000235587358475,
-0.012775726616382599,
-0.04122514650225639,
-0.08112579584121704,
0.0002931739145424217,
0.08732037246227264,
0.05612363666296005,
-0.04004063829779625,
0.1035156100988388,
0.08805084973573685,
-0.01860628090798855,
0.010821130126714706,
0.06378... |
with\tthe\treceptors\ton\tsensitized\nIgE\tantibodies\ton\tmast\tcells\tor\nbasophils.\tUpon\tbinding,\tchemical\ninflammatory\tmediators\tare\nreleased.\nT-cells\tand\nsometimes\neosinophils\tare\nassociated\twith\ntriggering\n\trelease\nof\tinflammatory\nmediators\tand\ndevelopment\tof\nsymptoms.\nA\ncombination\nof\... | [
0.023103851824998856,
-0.08626387268304825,
0.030033765360713005,
-0.004722225479781628,
-0.08589157462120056,
0.03384449705481529,
0.08345653116703033,
0.03634557127952576,
0.008465226739645004,
0.11146754771471024,
0.08997565507888794,
-0.08148543536663055,
-0.017925286665558815,
0.08493... |
A\ncombination\nof\tIgE\tand\nnon-IgE\nmechanisms\nTiming\nQuick\tonset\nFirst\tphase:\timmediate\treaction—\nminutes\tto\t1\thour\n*\nLate\tbiphasic\tphase:\tmay\toccur\nseveral\thours\t(4\tto\t6)\tafter\tinitial\nreaction\t(e.g.,\talpha\tgal)\nDelayed\tonset:\t>2\nhours;\toften\t4\tto\t6\nhours;\trelapsing\nDelayed\n... | [
0.024999603629112244,
-0.07491476833820343,
0.07380105555057526,
-0.08360034227371216,
-0.1535654217004776,
0.004580279812216759,
0.0638534277677536,
-0.01310283225029707,
0.025828508660197258,
0.11907415091991425,
0.08111295849084854,
-0.03858700022101402,
0.04342801123857498,
0.019415738... |
hours;\toften\n4\tto\t6\thours\nVolume\tRequired\n\tfor\nReaction\nSmall\nSometimes\tlarger\nSometimes\nlarger\nSystemic\nAnaphylaxis\nFood-associated\texercise\tinduced\nanaphylaxis\t(FEIA)\nNSAID-associated,\taspirin-\nassociated,\tor\talcohol-associated\nfood-induced\tanaphylaxis\nNA\nNA\nSkin\nGeneralized\turticari... | [
-0.004690013825893402,
-0.031919464468955994,
0.0027294207829982042,
0.07113824784755707,
-0.07827040553092957,
0.04346584528684616,
0.03509725630283356,
0.06311938166618347,
-0.02612357959151268,
0.0024236664175987244,
0.0669165849685669,
-0.013805696740746498,
-0.03488186001777649,
0.047... |
Acute\tcontact\turticaria\nAngioedema\nRash\nItching\nFlushing\nContact\tdermatitis\nDermatitis\nherpetiformis\nAtopic\ndermatitis\n(eczema)\t(see\nFig.\t25.3\n)\nGastrointestinal\tTract\nImmediate\tgastrointestinal\t(GI)\nhypersensitivity\tor\tspasm\nOral\tallergy\tsyndrome\t(OAS)\tor\npollen-food\tallergy\tsyndrome\n... | [
0.008619513362646103,
-0.02819572202861309,
0.01811334118247032,
-0.006309899967163801,
-0.0848347395658493,
-0.01125846616923809,
0.011344492435455322,
0.08102839440107346,
-0.10806232690811157,
0.08800087869167328,
0.07059155404567719,
0.008208019658923149,
0.051036614924669266,
0.075659... |
(PFAS)\nAbdominal\tpain\nNausea\nVomiting\nBelching\nBloating\nDiarrhea\nConstipation\nFood\tprotein–\ninduced\nenteropathy\nsyndromes\t(FPIES)\nFood\tprotein–\ninduced\nproctocolitis\t(FPIP)\nCeliac\tdisease\nEosinophilic\nesophagitis\t(EoE)\nEosinophilic\tgastritis\nEosinophilic\ngastroenteritis\n(EGE)\nNA\nRespirato... | [
0.022313831374049187,
-0.08682148158550262,
-0.02911382168531418,
0.034555427730083466,
-0.07308076322078705,
0.008414272218942642,
0.04177214577794075,
0.14905193448066711,
-0.023365233093500137,
0.06411392241716385,
0.039236072450876236,
0.013140978291630745,
0.06670596450567245,
0.08462... |
NA\nRespiratory\nAcute\trhinitis\t(stuffy\tnose)\nRhinorrhea\t(runny\tnose)\nAsthma\nBronchospasm\nLaryngeal\tedema\nNA\nAsthma\nCardiovascular\nHypotension\nDizziness\tor\tfainting\nNA\nNA\n*\t\nIn\tcontrast\tto\ttypical\tfood\tanaphylaxis\tthat\toccurs\twithin\tminutes\tto\t2\thours\tfollowing\tingestion\tof\tthe\ttr... | [
-0.002758248243480921,
-0.07751671224832535,
0.010334940627217293,
0.022512394934892654,
-0.09153331816196442,
-0.00438940292224288,
0.05034838244318962,
0.07215088605880737,
-0.016536451876163483,
0.052590228617191315,
0.12256286293268204,
-0.023599563166499138,
0.060260575264692307,
0.06... |
reactions\tto\tmammalian\tmeat,\n\twith\tthe\tsame\tanaphylaxis\tsymptoms\tare\tdelayed,\toccurring\t3\tto\t8\thours\tafter\tingestion.\nNA\n,\tNot\tapplicable.\nSources:\tNational\tAcademies\tof\tSciences,\tEngineering,\tand\tMedicine\t(NASEM),\tInstitute\tof\tMedicine\t(IOM)\t\nFinding\ta\tpath\tto\tsafety\tin\tfood\... | [
0.013737127184867859,
-0.058639563620090485,
0.013980447314679623,
-0.051536690443754196,
-0.02396734431385994,
0.05032432824373245,
0.04119878262281418,
0.09747636318206787,
0.03691145032644272,
0.09779782593250275,
0.1038612350821495,
-0.025408443063497543,
0.003941906150430441,
0.055463... |
Finding\ta\tpath\tto\tsafety\tin\tfood\tallergy:\nAssessment\tof\tthe\tglobal\tburden,\tcauses,\tprevention,\tmanagement,\tand\tpublic\tpolicy\n.\tWashington,\tDC:\tThe\tNational\tAcademies\tPress,\t2017\tp.\t40.\nRenz\tH,\tAllen\tKJ,\tSicherer\tSH,\tet\tal:\tFood\tallergy,\tNature\tReviews-Disease\tPrimers,\tvol\t4:\t... | [
-0.03067638911306858,
-0.014119607396423817,
0.019768545404076576,
-0.04211393743753433,
-0.03865890949964523,
-0.01471154484897852,
0.045247144997119904,
0.023773107677698135,
-0.007171825505793095,
0.04368994012475014,
0.10879117250442505,
-0.013023159466683865,
0.08297041058540344,
0.01... |
Joneja\tJV:\t\nThe\thealth\tprofessional’s\tguide\tto\tfood\tallergies\tand\tintolerances\n,\tChicago,\tIL,\t2013,\tAcademy\tof\tNutrition\tand\tDietetics.\nIgE-mediated\tfood\tallergies\nAlthough\tany\tfood\tcan\tcause\tan\tallergic\treaction,\ta\tsmall\tnumber\tof\tfoods\tcause\tthe\n\tvast\tmajority\tof\tIgE- | [
-0.0034887560177594423,
-0.0399959571659565,
0.02939893677830696,
-0.019462456926703453,
-0.06248049437999725,
0.0013013744028285146,
0.10192428529262543,
0.004001379944384098,
0.002675347961485386,
0.027342401444911957,
0.1001242846250534,
-0.04026824235916138,
0.04184601828455925,
0.0036... |
vast\tmajority\tof\tIgE-\nmediated\tfood\tallergies.\tFoods\tthat\tare\tmore\tlikely\tto\tinduce\tan\tallergic\tresponse\tvary\tby\tcountry\tand\nregion\tof\tthe\tworld\taccording\tto\ta\tpopulation’s\teating\thabits.\tIn\tthe\tUnited\tStates\tthe\tcommon\tallergenic\nfoods\tare\tcow’s\tmilk,\teggs,\tpeanuts,\ttree\tnu... | [
0.03123319521546364,
-0.02627374231815338,
0.07007613033056259,
-0.01566433720290661,
-0.0669315904378891,
-0.020920144394040108,
0.05560765787959099,
-0.005722952075302601,
-0.0373348705470562,
0.06773296743631363,
0.11537526547908783,
-0.10229827463626862,
0.013468721881508827,
-0.008602... |
NASEM,\t2017\n).\tAmong\tU.S.\nadults\twith\tfood\tallergies\tthe\tfive\tmost\tcommon\tfood\tallergies\n\tare\tshellfish\t(2.9%),\tpeanut\t(1.8%),\tmilk\n(1.9%),\ttree\tnuts\t(1.2%),\tand\tfin\tfish\t(0.9%)\t(\nGupta\tet\tal,\t2019\n).\tIn\tother\tcountries,\tfor\texample,\tJapan,\negg,\tcow’s\tmilk,\twheat,\tshellfish... | [
-0.052736930549144745,
-0.013474255800247192,
0.012300542555749416,
-0.06360486894845963,
-0.07130927592515945,
-0.07061109691858292,
0.05292438715696335,
0.024561915546655655,
-0.04630536586046219,
-0.0064727384597063065,
0.08398551493883133,
-0.1299944967031479,
0.03567705675959587,
0.00... |
(\nMatsuo\tet\tal,\t2015\n).\nThe\tmain\tIgE-mediated\tallergic\treactions\tare\tfood-induced\tanaphylaxis;\tfood-dependent,\texercise-\ninduced\tanaphylaxis\t(FDEIA);\n\t\ncow’s\tmilk\tprotein\tallergy\t(CMPA)\n;\toral\tallergy\tsyndrome\t(OAS),\twhich | [
-0.0019649644382297993,
0.016976425424218178,
-0.025124486535787582,
-0.030473995953798294,
-0.06281843036413193,
0.046214696019887924,
-0.01337471418082714,
0.12194875627756119,
0.014576934278011322,
0.052241794764995575,
0.12966392934322357,
-0.014959065243601799,
-0.008744859136641026,
... |
recently\tis\trecognized\tas\tbeing\ttwo\tsyndromes,\tpollen-food\tallergy\tsyndrome\t(PFAS)\tand\tlipid\ttransfer\nprotein\tsyndrome\t(LTPS);\tlatex-fruit\tor\tlatex-food\tsyndrome;\tand\tsystemic\tnickel\tallergy\tsyndrome\n(SNAS).\nFood-induced\tanaphylaxis\nFood-induced\t\nanaphylaxis\n\tis\tan\tacute,\tsystemic,\t... | [
0.009351999498903751,
-0.031197093427181244,
-0.011966338381171227,
0.004372005816549063,
-0.021700004115700722,
0.062089405953884125,
0.028969597071409225,
0.10315772145986557,
-0.02465129643678665,
0.04385638236999512,
0.12548315525054932,
0.012957911938428879,
0.02879822626709938,
0.047... |
response\nthat\tusually\toccurs\twithin\ta\tlimited\tperiod\tfollowing\texposure\tto\ta\tfood\tantigen.\tMultiple\torgan\tsystems\nare\taffected.\tSymptoms\tinclude\trespiratory\tdistress,\tabdominal\tpain,\tnausea,\tvomiting,\tcyanosis,\narrhythmia,\thypotension,\tangioedema,\turticaria,\tdiarrhea,\tshock,\tcardiac\ta... | [
0.01791764236986637,
-0.019263368099927902,
0.03639446943998337,
0.003610344836488366,
-0.04645538330078125,
-0.0009369209292344749,
0.08935680985450745,
0.007099715527147055,
0.008717469871044159,
0.0444609709084034,
0.07543065398931503,
-0.06773518770933151,
0.061264533549547195,
0.00694... |
The\tvast\tmajority\tof\tanaphylactic\treactions\tto\tfoods\tin\tadults\tin\tNorth\tAmerica\tinvolve\tpeanuts,\n\ttree\nnuts,\tfish,\tand\tshellfish.\tIn\tchildren,\tpeanuts\tand\ttree\tnuts\tare\tthe\tmost\tcommon\tcauses\tof\tanaphylactic\nreactions,\tbut\tanaphylactic\treactions\tto\tcow’s\tmilk\tand\teggs\thave\tbe... | [
-0.025125134736299515,
-0.006514480337500572,
0.03914572298526764,
-0.057238075882196426,
-0.04836816340684891,
-0.0033087844494730234,
0.03772934153676033,
0.024861155077815056,
-0.02195930853486061,
0.05739281699061394,
0.10153987258672714,
-0.09430032968521118,
-0.021586300805211067,
0.... |
common\tfood\tallergen\tin\tfatal\tanaphylactic\treactions\t(\nTurnbull\tet\tal,\t2015\n).\nPeople\twith\tknown\tanaphylactic\treactions\tto\tfood\tallergens\tshould\tcarry\tand\tbe\tprepared\tto\tuse\nepinephrine\n\tvia\ta\tportable\tinjectable\tdevice\t(often\tcalled\tan\tEpiPen)\tat\tall\ttimes.\tEpinephrine\tis\tth... | [
0.03398006036877632,
-0.04474727809429169,
0.03986760973930359,
-0.049833498895168304,
-0.08111745119094849,
0.02889249287545681,
0.07829396426677704,
0.07823839783668518,
-0.023829150944948196,
0.059016965329647064,
0.1323842704296112,
-0.03528866171836853,
-0.025081321597099304,
0.079768... |
of\tchoice\tto\treverse\tan\tallergic\tanaphylactic\treaction.\tDelayed\tuse\tof\tepinephrine\thas\tbeen\tassociated\nwith\tan\tincreased\trisk\tof\tbiphasic\treactions,\tin\twhich\ta\trecurrence\tof\tsymptoms\t4\tto\t12\thours\tafter\tthe\ninitial\tanaphylactic\treaction\tmay\tbe\tfatal.\tSee\tSimons\t(2014)\tfor\tman... | [
0.015192070044577122,
-0.03405622020363808,
0.05077725648880005,
-0.027182605117559433,
-0.08810850977897644,
0.030064605176448822,
0.07971952110528946,
0.06409861147403717,
0.009281808510422707,
0.06382379680871964,
0.11401982605457306,
-0.02714923396706581,
-0.010692265816032887,
0.04999... |
reaction\nand\tthe\twebsite\tfor\tFood\tAllergy\tResearch\tand\tEducation\t(FARE).\tImmediate\tcoordination\tof\tcare\tand\nreferral\tto\ta\tphysician\tspecializing\tin\tallergy\tmedicine\tis\tessential\tfor\tpatient\tsafety.\tIf\tyou\twitness\ta\nsevere\tallergic\tresponse\tor\tanaphylaxis,\tcall\t911\timmediately\tan... | [
0.005969944875687361,
-0.007788110990077257,
0.0443209707736969,
-0.05118830129504204,
-0.043437328189611435,
0.046503204852342606,
0.058417629450559616,
0.08075962215662003,
0.020284321159124374,
0.09744976460933685,
0.12007979303598404,
-0.04578988254070282,
0.0017158673144876957,
0.0481... |
cardiopulmonary\tresuscitation\t(CPR)\tif\tnecessary.\nFood-dependent,\texercise-induced\tanaphylaxis\n\t(FDEIA)\nFood-dependent,\texercise-induced\tanaphylaxis\t(FDEIA)\n\tis\ta\trare\tdistinct\tform\tof\tallergy\tin\twhich\tan\noffending\tfood\ttriggers\tan\tIgE-mediated\tanaphylactic\treaction\tonly\twhen\tthe\tsens... | [
0.0005969532649032772,
-0.03128928318619728,
-0.02332327328622341,
0.022176869213581085,
-0.05715695023536682,
0.029679760336875916,
0.055252645164728165,
0.07240995764732361,
0.016991296783089638,
0.04489688575267792,
0.12528029084205627,
-0.04410380497574806,
-0.02352849766612053,
0.0929... |
exercises\twithin\t2\tto\t4\thours\tafter\teating,\tor\toccasionally,\tbefore\teating\tthe\tfood.\tSigns\tof\tdeveloping\nanaphylaxis\tare\turticaria\t(hives),\tpruritus\t(itching),\tand\terythema\t(reddening)\tfollowed\n\tby\tbreathing\ndifficulty\tand\tGI\tsymptoms.\tThe\tingestion\tof\tthe\tfood\tis\tnot\tproblemati... | [
0.022879749536514282,
-0.05340481922030449,
0.06693587452173233,
-0.017346562817692757,
-0.10475905984640121,
0.015002257190644741,
0.11575791984796524,
0.04283224046230316,
-0.061956536024808884,
0.04305771365761757,
0.033310845494270325,
0.008201146498322487,
0.02824355475604534,
0.03556... |
exercise\tis\tnot\tproblematic\tin\tthe\tabsence\tof\tconsumption\tof\tthe\tfood.\tFDEIA\tappears\tto\tbe\tmore\ncommon\tin\tadolescents\tand\tyoung\tadults,\tand\tin\tthose\twith\tknown\tfood\tallergy\tor\ta\thistory\tof\nanaphylaxis.\tShellfish,\tseafood,\tcertain\tfruits,\tcow’s\tmilk,\tcelery,\ta\tgliadin\tcomponen... | [
-0.027381332591176033,
-0.03031207248568535,
0.031942784786224365,
-0.03831753879785538,
-0.0821608230471611,
0.034321531653404236,
0.1042424738407135,
-0.006834106519818306,
-0.04245411604642868,
0.03970426693558693,
0.09585396945476532,
-0.07390312850475311,
0.033658288419246674,
0.01100... |
in\twheat,\tand\tother\nfoods\thave\tbeen\treported\tas\toffending\tagents\t(\nAsaumi\tand\tEbisawa,\t2018\n).\nIn\tFDEIA,\tthe\tcombination\tof\ta\tsensitizing\tfood\tand\texercise\tprecipitates\tsymptoms,\tpossibly\trelated\tto\nincreased\tGI\tpermeability\tand\tabsorption,\tblood-flow\tredistribution,\tand\tincrease... | [
-0.00030074562528170645,
-0.046386994421482086,
0.005726058967411518,
-0.02417827770113945,
-0.04824277013540268,
-0.029128096997737885,
0.10365220904350281,
0.026780076324939728,
0.028858084231615067,
0.0320296436548233,
0.09948689490556717,
-0.07129553705453873,
0.008715808391571045,
0.0... |
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