Nason/clinicaltrials-database

ClinicalTrials.gov Database (AACT)

A clean, queryable DuckDB database built from the AACT flat files -- the most comprehensive structured export of ClinicalTrials.gov data.

56,397,018 rows across 48 tables covering every registered clinical trial.

Built with clinicaltrials-database.

Quick Start

DuckDB CLI

INSTALL httpfs;
LOAD httpfs;
ATTACH 'https://huggingface.co/datasets/Nason/clinicaltrials-database/resolve/main/clinicaltrials.duckdb' AS ct (READ_ONLY);

-- Trials by phase
SELECT overall_status, COUNT(*) as n
FROM ct.studies
GROUP BY overall_status
ORDER BY n DESC;

Python

import duckdb
con = duckdb.connect()
con.sql("INSTALL httpfs; LOAD httpfs;")
con.sql("""
    ATTACH 'https://huggingface.co/datasets/Nason/clinicaltrials-database/resolve/main/clinicaltrials.duckdb'
    AS ct (READ_ONLY)
""")
con.sql("SELECT * FROM ct.studies LIMIT 5").show()

DuckDB uses HTTP range requests, so only the pages needed for your query are downloaded.

Tables

Table	Description	Rows
reported_events	Summary of reported adverse events	11,446,277
outcome_measurements	Summary data for outcome measures by study group	4,777,352
browse_conditions	NLM-generated MeSH terms for study conditions	4,194,046
design_outcomes	Planned outcome measures and observations	3,566,612
facilities	Facility names, addresses, and recruiting status	3,410,973
baseline_measurements	Demographic and baseline measures by group	2,808,533
browse_interventions	NLM-generated MeSH terms for study interventions	2,480,003
result_groups	Aggregate list of group titles/descriptions for results reporting	2,120,694
outcome_counts	Sample sizes for each outcome by study group	1,537,817
keywords	Investigator-provided keywords describing the study	1,523,516
design_group_interventions	Cross-reference mapping design groups to interventions	1,283,125
study_references	Citations to publications related to the study	1,078,399
design_groups	Protocol-specified groups or cohorts assigned to interventions	1,056,031
conditions	Disease or condition names studied in each trial	1,025,650
interventions	Interventions or exposures: drugs, devices, procedures, vaccines	973,952
sponsors	Sponsor and collaborator names and types	920,618
milestones	Participant progress through each stage of the study	855,865
countries	Countries where the study has sites	783,722
id_information	Identifiers other than NCT ID (org study IDs, secondary IDs)	748,312
outcomes	Outcome measure descriptions and time frames	638,016
outcome_analysis_groups	Groups involved in each outcome analysis	609,509
drop_withdrawals	Summary of participant withdrawals: counts and reasons	577,923
reported_event_totals	Totals of reported adverse events by category	577,536
calculated_values	AACT-computed fields: months to report results, facilities count, etc.	576,029
studies	Core study record: title, status, phase, type, dates, enrollment, and regulatory info	576,029
brief_summaries	Brief text summary of the study protocol	575,064
detailed_descriptions	Detailed text description of the study protocol	575,064
eligibilities	Participant eligibility criteria (inclusion/exclusion, age, sex)	575,064
designs	Study design details: allocation, masking, assignment, purpose	571,286
responsible_parties	Parties responsible for submitting study information	557,553
overall_officials	People responsible for overall scientific leadership	519,601
search_term_results		494,618
intervention_other_names	Synonymous names for interventions	470,456
facility_contacts	Contact information at each study facility	409,886
outcome_analyses	Statistical analyses performed on outcomes	315,026
baseline_counts	Sample sizes at baseline for each study group	230,199
facility_investigators	Investigator names at each study facility	223,509
central_contacts	Primary and backup contacts for enrollment questions	217,960
ipd_information_types	Individual participant data sharing information types	87,849
provided_documents	Protocol, SAP, and informed consent form documents	78,018
result_contacts	Points of contact for scientific information about results	76,963
result_agreements	Agreements between sponsor and principal investigators about results	76,963
participant_flows	Recruitment and pre-assignment details	76,963
links	Web links relevant to the study	74,921
pending_results	Events related to submission of results for QC review	32,304
documents	Full study protocol and statistical analysis plan	10,692
retractions	Retraction notices for study results or publications	334
search_terms		186

Data Source

AACT (Aggregate Analysis of ClinicalTrials.gov) -- maintained by the Clinical Trials Transformation Initiative (CTTI). Updated daily from ClinicalTrials.gov. This is public domain U.S. government data.

License

Database build code: MIT. Underlying data: public domain (U.S. government work).

GitHub

Full source code, build instructions, and data dictionary: github.com/ian-nason/clinicaltrials-database