PMCID string | Title string | Sentences string |
|---|---|---|
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | 8 Imatinib resistance analysis and drug sensitivity prediction. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | A-C) Boxplots depicting the expression levels of LARP7 among untreated, imatinib-sensitive, and imatinib-resistant GIST patients in GSE132542, GSE51697, and Proteomics (Sun et al.). ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | D-E) Box plot and point plot showing the relationship between the predicted IC50 values of UMI-77 and LARP7 expression in GSE225819. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Box plot displaying the top 10 drugs with predicted IC50 values significantly lower in the LARP7 high-expression group in GSE136755. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Point plot indicating the top 10 drugs whose predicted IC50 values were negatively correlated with LARP7 in GSE136755. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Subsequently, we aimed to predict drugs that target LARP7 based on the extensive data from GDSC_v2. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | In GSE225819, the IC50 values of UMI-77, a Myeloid cell leukemia-1 (Mcl-1) inhibitor, were significantly lower in the LARP7 high-expression group (Fig. 8D) and exhibited a significant negative correlation with LARP7 expression (Fig. 8E). |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | In GSE136755, we identified 74 drugs that demonstrated potential efficacy in LARP7 high-expression group (Fig. 8F, 8G and Table S7). |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Notably, Teniposide (a topoisomerase II inhibitor), Carmustine (a DNA alkylator/crosslinker), and GSK2578215A (an LRRK2 inhibitor) exhibited the most promising results in our predictive analysis. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | These findings suggest that LARP7 may be implicated in the imatinib resistance observed in GIST patients, and several drugs have the potential to address this challenge. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Through qRT-PCR and western blotting detection of four pairs of cancer and para-cancerous tissues from GIST patients, it was confirmed that LARP7 was up-regulated in GIST tumor tissues at the clinical level (Fig. 9A and B). |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | To validate the role of LARP7 in promoting GIST, knockdown experiments were conducted in vitro in GIST cancer cell lines. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Results showed that all three siRNAs demonstrated effective LARP7 knockdown at the mRNA (Fig. 9C) and protein levels (Fig. 9D) in GIST-T1 and GIST-882 cells. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | The siLARP7–2 exhibited the best effect and was used in subsequent experiments. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | In the CCK8 assay, the GIST-T1 and GIST-882 cells with inhibited LARP7 expression exhibited a reduced growth pattern compared to the scrambled vector group (Fig. 9E). |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | The wound healing assay displayed a slower healing rate in the LARP7 knockdown groups (Fig. 9F). |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | These results confirmed that LARP7 down-regulation significantly reduced GIST-T1 and GIST-882 cell proliferation and migration. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Fig. 9The role of LARP7 in promoting cell proliferation and migration in GIST-T1 and GIST-882 cells. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | A-B) The expression of LARP7 in four para-cancerous tissues and paired GISTs evaluated using qRT-PCR and western blot analysis. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | GIST-T1 and GIST-882 cells with LARP7 knockdown via three siRNAs were assessed using qRT-PCR, with LARP7 mRNA expression normalized to GAPDH levels. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | GIST-T1 and GIST-882 cells subjected to either control or siLARP7 were harvested to evaluate LARP7 expression through western blot analysis. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | CCK8 assays were performed on GIST-T1 and GIST-882 cells transfected with either control or siLARP7–2 at 24, 48, 72, and 96 h. (F) Wound healing assays were conducted to compare cell migration between the LARP7-inhibited group and the control group, with evaluations conducted 48 h post-transfection in both GIST-T1 and GIST-882 cells. *: |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | p < 0.05; **: p < 0.01; ***: p < 0.001; ****: p < 0.0001.Fig. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | 9 The role of LARP7 in promoting cell proliferation and migration in GIST-T1 and GIST-882 cells. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | A-B) The expression of LARP7 in four para-cancerous tissues and paired GISTs evaluated using qRT-PCR and western blot analysis. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | GIST-T1 and GIST-882 cells with LARP7 knockdown via three siRNAs were assessed using qRT-PCR, with LARP7 mRNA expression normalized to GAPDH levels. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | GIST-T1 and GIST-882 cells subjected to either control or siLARP7 were harvested to evaluate LARP7 expression through western blot analysis. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | CCK8 assays were performed on GIST-T1 and GIST-882 cells transfected with either control or siLARP7–2 at 24, 48, 72, and 96 h. (F) Wound healing assays were conducted to compare cell migration between the LARP7-inhibited group and the control group, with evaluations conducted 48 h post-transfection in both GIST-T1 and GIST-882 cells. *: |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | p < 0.05; **: p < 0.01; ***: p < 0.001; ****: p < 0.0001. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | To explore the unknown factors in GIST tumorigenesis, we combined transcriptional RNA-seq data and proteomic data to screen for potential key genes. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | After filtering based on their significance in relation to PFS, we identified 35 up-regulated DEGs/DEPs. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Notably, upon examining the background of these genes, we found that many were associated with epigenetic regulation, including ANP32E, CDH11, MSI2, and SYMD4. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | As previously mentioned, a group of transcription factors and chromatin remodeling factors were found to be essential for sustaining GIST proliferation and KIT expression. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Inhibition of MOZ and Menin-MLL complexes resulted in decreased GIST cell proliferation by disrupting interactions with transcriptional and chromatin regulators, such as DOT1 L . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Furthermore, G protein-coupled receptor 20 (GPR20) has recently been identified as a non-tyrosine kinase target in GIST , which was also noted in our results. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | La ribonucleoprotein 7 (LARP7), a member of the La-related protein family, encoded a protein that binds to 7SK RNA. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | This protein was a key component of the 7SK small nuclear ribonucleoprotein (snRNP) complex, which critical in regulating RNA polymerase II pausing by negatively modulating the PTEF-b complex. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | In breast cancer, BRCA1/BARD1 catalyzed the K48 polyubiquitination of LARP7, thereby promoting the G2/M transition and the DNA damage response following ionizing radiation . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | LARP7 has been identified as a potential tumor suppressor in gastric and follicular thyroid cancers . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Conversely, under the regulation of HOGA1, LARP7 facilitated the progression of pancreatic ductal adenocarcinoma . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | In cooperating with TRIM28, LARP7 inhibited endothelial-to-mesenchymal transition and valvulogenesis . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Additionally, LARP7 can enhance SIRT1 deacetylase activity, which contributed to the slowing of cellular aging . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | LARP7 also involved in regulating mRNA stability and translation processes. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | A deficiency in LARP7 has been linked to impaired telomere maintenance in Alazami syndrome . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | However, the role of LARP7 in the pathogenesis of GIST remained to be fully elucidated. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Our study provided the first evidence that LARP7 functioned as an oncogene in GIST and was significantly associated with the GIST prognosis. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Functional enrichment analysis revealed a significant up-regulation of genes involved in interferon signaling, negative regulation of viral processes, expression of IFN-induced genes, antigen processing and presentation, T cell-mediated cytotoxicity, and other related pathways. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Notably, these functions have not been identified in any cancer types, and only the 7SK snRNP complex has been previously implicated in the process of HIV-1 latency . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Recently, GBP1, the sole DEGs/DEPs identified between high and low LARP7 expression groups in our results, has been reported to play a role in guarding against pathogen infection , promoting tumorigenesis , and contributing to drug resistance . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | These findings further suggest that LARP7, in conjunction with GBP1, may participate in gastrointestinal resistance to viral infection. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | The interaction between LARP7 and GBP1 will be further explored in subsequent studies. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | A single-cell RNA-seq analysis of intra- and peri‑tumor tissues from GIST patients demonstrated that T cells constitute the largest proportion of immune cells in the microenvironment . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Our findings indicated that GISTs with high LARP7 expression exhibited increasing infiltration of CD8+ T cells. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Additionally, predictive analysis of cytokine pathway status revealed that the IFN1, IFNG, and IL27 signaling pathways were activated in high LARP7 expression groups. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Furthermore, we observed that the correlation between IFN-related pathway activation and LARP7 expression was particularly pronounced within a small subset of GIST patients, as illustrated in Fig. 6B. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | The detection of LARP7 aided in further stratifying patients with GIST, and the characteristics of this small subset of patients warrant detailed investigation. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | In our network analysis, we predicted that H19 or LINC00665 targeted hsa-miR-138–5p, which negatively regulated LARP7 expression in GIST. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Extensive research has shown that the lncRNA H19 promotes cancer progression, metastasis, and drug resistance , a function also attributed to the lncRNA LINC00665 . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | The hsa-miR-138–5p was associated with cancer cell proliferation and drug resistance across various cancers, including prostate cancer , colorectal cancer , cervical cancer , and renal cell carcinoma . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Notably, the LINC00665/hsa-miR-138–5p/SIN3A axis has been shown to modulate the progression of colorectal cancer . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | While not directly related to cancer, the interaction between H19 and hsa-miR-138–5p has been reported in rat models of severe acute pancreatitis . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | These lncRNAs and miRNA played crucial roles in epigenetic regulation by targeting key transcription factors and chromatin regulators, and their relationship with LARP7 will be experimentally validated in future studies. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | In the RBP-mRNA network, LARP7 was targeted by IGF2BP2 and YTHDC1, suggesting that LARP7 may be regulated through N(6)-methyladenosine (m6A) modification. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | SCAF4 and SCAF8, function as anti-terminators, suppressed early mRNA termination . |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | The relationship between these RBPs and LARP7 also presented a compelling narrative regarding mRNA metabolism. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Although we found that LARP7 was significantly up-regulated in imatinib-resistant GISTs at the transcriptional level, further analysis and experiments are necessary to elucidate the role of LARP7 in drug resistance. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Predictive drugs such as UMI-77 (an established BH3-mimetic for MCL-1), Carmustine (an alkylating agent), and other agents were identified, which may assist in the treatment of GIST. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | However, our study was limited by a small sample size and a lack of survival data. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Future research utilizing advanced technologies will be essential to fully characterize the role of LARP7 in GIST pathophysiology. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Four paired cancer and para-cancerous tissues from GIST patients validated LARP7 expression was up-regulated in tumor. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Both the CCK8 and wound healing assays demonstrated that the knockdown of LARP7 inhibited the proliferation and migration of GIST-T1 and GIST-882 cells. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | We have demonstrated the cancer-promoting function of LARP7 in clinical samples and in vitro experiments, but our sample size was relatively small and further experiments were pending. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Samples containing prognostic information were still being collected. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | In vivo experiments and specific experiments related to epigenetics were ongoing. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | LARP7 served as a link between risk factors such as viral infections and the dysfunction of epigenetic mechanisms in GIST. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | In summary, the detection of LARP7 expression in GIST holds promise for early-stage diagnosis, ongoing surveillance for potential recurrence, and the prediction of therapy response. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | GISTs characterized by high expression of LARP7 exhibited aggressive clinicopathological features, leading to an increased risk of relapse in patients following treatment. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | This study provided valuable insights for the further exploration of personalized therapeutic strategies for GIST. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | This study protocol was granted approval by the Ethics Committee of Sichuan Provincial People's Hospital (Approval Number: 2024–226), adhering to the principles of the Declaration of Helsinki. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Each patient provided written informed consent and approved the utilization of their tissues for research purposes. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Figure S1. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Functional enrichment results of down-regulated DEGs/DEPs. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Functional enrichment network of 281 commonly down-regulated DEGs/DEPs using ClueGO. ( |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Point plot displaying the top 35 prognosis-related genes in the down-regulated group. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | The point color indicates the absolute value of log2(fold change) for each gene/protein. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | The point size reflects the value of -log10(p value). |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | The bar plot in the right panel represents the relationship with PFS for each protein. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Heng Zheng: Writing – review & editing, Writing – original draft, Visualization, Validation, Software, Project administration, Methodology, Formal analysis, Data curation, Conceptualization. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | Yong Pan: Writing – review & editing, Writing – original draft, Validation, Software, Project administration, Methodology, Formal analysis, Data curation, Conceptualization. |
PMC11867541 | Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors | The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
PMC10669966 | PDE3A Is a Highly Expressed Therapy Target in Myxoid Liposarcoma | Liposarcomas (LPSs) are common soft-tissue sarcoma subtypes. |
PMC10669966 | PDE3A Is a Highly Expressed Therapy Target in Myxoid Liposarcoma | There is an unmet clinical need for targeting LPS-subtype-specific highly expressed genes. |
PMC10669966 | PDE3A Is a Highly Expressed Therapy Target in Myxoid Liposarcoma | We investigated RNA sequence data from a large clinical LPS sample series and an in silico transcriptome database consisting of 201 tissue types. |
PMC10669966 | PDE3A Is a Highly Expressed Therapy Target in Myxoid Liposarcoma | We discovered that the PDE3A gene is highly expressed in the myxoid LPS subtype. |
PMC10669966 | PDE3A Is a Highly Expressed Therapy Target in Myxoid Liposarcoma | In addition, PDE3A served as a drug target for PDE3A modulators in LPS cell lines, warranting further studies toward its usage in clinical therapy. |
PMC10669966 | PDE3A Is a Highly Expressed Therapy Target in Myxoid Liposarcoma | Liposarcomas (LPSs) are a heterogeneous group of malignancies that arise from adipose tissue. |
PMC10669966 | PDE3A Is a Highly Expressed Therapy Target in Myxoid Liposarcoma | Although LPSs are among the most common soft-tissue sarcoma subtypes, precision medicine treatments are not currently available. |
PMC10669966 | PDE3A Is a Highly Expressed Therapy Target in Myxoid Liposarcoma | To discover LPS-subtype-specific therapy targets, we investigated RNA sequenced transcriptomes of 131 clinical LPS tissue samples and compared the data with a transcriptome database that contained 20,218 samples from 95 healthy tissues and 106 cancerous tissue types. |
PMC10669966 | PDE3A Is a Highly Expressed Therapy Target in Myxoid Liposarcoma | The identified genes were referred to the NCATS BioPlanet library with Enrichr to analyze upregulated signaling pathways. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.