PMCID string | Title string | Sentences string |
|---|---|---|
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | This process is orchestrated by autophagy-related genes (ATGs), evolutionarily conserved from yeast to mammals . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Initiation occurs under nutrient deprivation or stress, leading to mTORC1 inactivation and activation of the ULK1/2 complex . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | The ULK complex, comprising ULK1/2, ATG13, and ATG101, promotes phagophore formation. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | PI3P production by the VPS34 complex I, modulated by Bcl-2, recruits WIPI proteins and facilitates Atg12-Atg5-Atg16L1 complex formation, driving LC3 lipidation and autophagosome maturation . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Autophagy exhibits a context-dependent dual role in tumor biology. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | On the one hand, it functions as a cytoprotective mechanism under metabolic and oxidative stress, enabling tumor cells to sustain viability under hypoxia, nutrient scarcity, or therapeutic insult . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | In GIST, c-KIT mutations are associated with aberrant autophagy activation, enhancing resistance to apoptosis and contributing to therapeutic resistance . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Enhanced autophagic flux under stress conditions delays senescence, facilitates immune evasion, and sustains tumor proliferation . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Conversely, persistent or excessive autophagy may elicit autophagic cell death. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | In GIST, knockout of ATGs such as ATG7 sensitizes tumor cells to IM, highlighting autophagy as a mechanism of drug resistance and a potential therapeutic target . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Elevated expression of autophagy markers correlates with unfavorable prognosis in several cancers . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Inhibition of autophagy using lysosomal blockers like chloroquine impedes autophagosome-lysosome fusion, potentiating IM-induced cytotoxicity . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | This dualistic nature of autophagy underscores its therapeutic complexity and offers the potential for context-specific modulation. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Research on the therapeutic effects of IM in GISTs has traditionally emphasized its capacity to induce apoptosis. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | However, apoptosis and autophagy, often initiated by overlapping upstream signaling pathways, engage in distinct and sometimes opposing cellular functions. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Apoptosis is widely recognized as a tumor-suppressive mechanism, whereas the role of autophagy remains context-dependent, influenced by tumor stage, oncogenic mutations, and microenvironmental conditions . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Emerging evidence suggests that IM resistance may be mediated, at least in part, through autophagy, regulated by various molecular factors, including ncRNAs . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Accordingly, elucidating the interplay between TKI-induced autophagy and apoptosis in GISTs may uncover novel strategies to overcome drug resistance (Fig. 3).Fig. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | 3Role of Autophagy in GIST Cell Drug Resistance (Created by BioRender). |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | This figure explores the response of GIST cells to IM treatment. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Autophagy levels significantly increase post-treatment, especially in drug-resistant GIST cells. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Chloroquine, an autophagy inhibitor, may promote apoptosis by blocking autophagy, suggesting potential therapeutic effects Role of Autophagy in GIST Cell Drug Resistance (Created by BioRender). |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | This figure explores the response of GIST cells to IM treatment. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Autophagy levels significantly increase post-treatment, especially in drug-resistant GIST cells. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Chloroquine, an autophagy inhibitor, may promote apoptosis by blocking autophagy, suggesting potential therapeutic effects A pivotal study by Miselli et al. (2008) examined surgical specimens from 11 GIST patients with confirmed molecular characteristics who received IM therapy, compared to 2 untreated patients. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | The IM-treated group exhibited elevated expression of the pre-autophagic marker Beclin1/PI3KIII and reduced anti-autophagic Beclin1/Bcl-2 complex levels. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Notably, apoptosis-related proteins were undetectable in these samples. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | These findings suggest that in untreated tumors, IM may induce anti-tumor activity via KIT autophagy, whereas in pretreated tumors, a subset of GIST cells may transition into a quiescent state-retaining proliferative potential upon IM discontinuation or acquisition of resistance mutations . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Further supporting this notion, Gupta et al. demonstrated that GIST cell survival and dormancy during IM therapy are associated with a stabilized tumor burden. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Despite limited apoptotic induction by IM, autophagic vesicle formation was observed as early as 8 h post-treatment, particularly in IM-sensitive cells. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Importantly, a negative correlation between autophagy and apoptosis was established. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | These findings underscore autophagy's critical role in maintaining GIST cells in a quiescent, reversible, non-proliferative state. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | This dormancy allows tumor cells to withstand intrinsic vulnerabilities and therapeutic stress, ultimately contributing to recurrence and the development of drug resistance. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Autophagy is tightly regulated by several signaling pathways, among which mTOR and AMP-activated protein kinase (AMPK) are the most prominent. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | The mechanistic target of rapamycin (mTOR) serves as a negative regulator of autophagy by integrating upstream signals such as PI3K/Akt. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | It suppresses autophagy initiation by phosphorylating ULK1 complex components, including ULK1 and Atg13. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | In GIST, hyperactivation of mTOR correlates with increased tumor growth, invasiveness, and therapeutic resistance. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Notably, mTOR signaling enhances cellular metabolism and restrains autophagic cell death, contributing to treatment evasion . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | As a result, mTOR inhibitors like rapamycin have been widely explored as modulators of autophagy and potential anticancer agents. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Rapamycin has demonstrated efficacy in suppressing GIST cell proliferation and enhancing chemotherapy sensitivity . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Conversely, AMPK functions as a cellular energy sensor and positive regulator of autophagy. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Under energy stress, AMPK inhibits mTOR signaling and directly activates autophagy to restore metabolic homeostasis. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | In GIST, AMPK activation has been shown to inhibit tumor cell proliferation and promote apoptosis while enhancing autophagy and alleviating mTOR-mediated suppression . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Beyond autophagy induction, AMPK modulates lipid metabolism and glycolysis, creating a more vulnerable metabolic state in tumor cells. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Small-molecule AMPK activators have improved chemotherapeutic responses in preclinical GIST models, highlighting their potential as therapeutic agents . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | In summary, mTOR and AMPK are opposing autophagy regulators and play critical roles in GIST pathogenesis and drug response. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Therapeutically targeting this regulatory axis offers promising opportunities to overcome resistance in GIST and other malignancies. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Silencing of autophagy-related genes ATG7 and ATG12 via RNA interference, or pharmacological inhibition of lysosomes using antimalarial agents, has synergized with IM to induce GIST cell death . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Song et al. reported that autophagy activity is significantly elevated in IM-resistant GIST cell lines compared to sensitive ones. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Importantly, co-treatment with chloroquine, a lysosomal inhibitor, and IM suppressed autophagy via the MAPK/ERK pathway, enhancing cytotoxicity and overcoming drug resistance . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Chloroquine disrupts autophagosome-lysosome fusion, and its combination with IM reduces LC3-II expression, increases chemotherapy sensitivity, and exerts potent tumor-suppressive effects in GIST mouse models (Fig. 3). |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Beyond lysosomal inhibition, targeting heat shock proteins (HSPs) has emerged as another promising strategy. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | As molecular chaperones, HSPs stabilize oncogenic proteins such as mutant KIT. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Inhibition of HSP90 using NVP-AUY922 (AUY922) facilitates KIT degradation via proteasomal and autophagic pathways. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | AUY922 effectively suppresses the growth of both IM-sensitive (GIST882) and IM-resistant (GIST48) cells. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | However, when autophagy is blocked, the KIT protein accumulates, highlighting the critical role of autophagy in KIT turnover induced by HSP90AA1 inhibition . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Subsequent studies demonstrated that rapamycin, an mTOR inhibitor, reduces total and phosphorylated KIT levels in IM-resistant GIST cells. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Combined treatment with rapamycin and AUY922 produces a synergistic antiproliferative effect in vitro . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Mechanistically, the tyrosine kinase WEE1 promotes KIT degradation by repressing Beclin1 and enhancing the LC3BII/I ratio, thus facilitating autophagic flux . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | A reciprocal relationship between autophagy and apoptosis has been widely observed in GIST. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | The X-linked inhibitor of apoptosis protein (XIAP), which suppresses apoptosis, becomes stabilized in IM-treated GIST-882 cells due to decreased ubiquitination. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | It is accompanied by increased autophagy, suggesting that the ubiquitin–proteasome system may modulate autophagic activity and contribute to secondary resistance . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Autophagy regulation also involves post-translational and epigenetic mechanisms. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | ATG5 is stabilized by the deubiquitinase USP13 in a PAK1-dependent manner, with USP13 is transcriptionally regulated by the methyltransferase METTL3 . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | In addition, recent studies have uncovered a neurotrophic signaling axis in GIST. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | The GDNF-GFRA1 pathway interacts with the lysosomal calcium channel MCOLN1, activating Ca-dependent TFEB signaling. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | TFEB subsequently upregulates lysosomal gene expression, amplifies autophagic flux, and inhibits apoptosis under TKI treatment. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Dual inhibition of GFRA1 and autophagy demonstrates promising potential for overcoming drug resistance in GIST therapy . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Ferroptosis is a distinct form of PCD characterized by iron-dependent lipid peroxidation and reactive oxygen species (ROS) accumulation. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Unlike apoptosis or necrosis, ferroptosis is driven by intracellular iron overload, which catalyzes Fenton reactions to generate hydroxyl radicals that damage polyunsaturated fatty acids (PUFAs) in membrane phospholipids, ultimately leading to cell death . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Beyond its role in tumor suppression, ferroptosis is implicated in various pathological conditions, including neurodegenerative, cardiovascular, and hepatic diseases. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | A central ferroptosis regulator is glutathione peroxidase 4 (GPX4), which protects cells by reducing lipid peroxides. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Inhibition or loss of GPX4 function induces ferroptosis. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | The small-molecule RSL3 is a well-characterized GPX4 inhibitor that irreversibly inactivates GPX4, promoting lipid peroxidation and cell death. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | RSL3 has shown potent anti-tumor activity across multiple cancer models and enhances chemotherapy efficacy, particularly in drug-resistant tumors . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Co-administration with other ferroptosis inducers, such as FIN56, amplifies tumor cell death . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Furthermore, GPX4 inhibitors elevate ROS levels, stimulate T and NK cell activation, and improve tumor immune surveillance . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | In vivo studies confirm their tolerability and efficacy against solid tumors, including GIST . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Ferroptosis induction in GIST is primarily mediated by ROS generated through mitochondrial respiration and the NADPH oxidase (NOX) family. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | These ROS disrupt membrane integrity, triggering ferroptosis. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Their clearance depends largely on the xc-glutathione (GSH)-GPX4 axis, with additional antioxidant inputs from coenzyme Q10 and tetrahydrobiopterin (Fig. 4). |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | GPX4 utilizes GSH, supplied by cysteine imported through the xc cystine/glutamate antiporter system, to neutralize lipid ROS and maintain redox homeostasis. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Fig. 4Metabolic Regulation and Drug Targets in Ferroptosis Pathway (Created by BioRender). |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | This figure outlines the key molecular mechanisms of the ferroptosis pathway, including the interactions between GSH, PUFAs, and iron ions. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Drugs such as IM and vorinostat may also enhance anti-tumor effects by modulating ferroptosis-related pathways Metabolic Regulation and Drug Targets in Ferroptosis Pathway (Created by BioRender). |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | This figure outlines the key molecular mechanisms of the ferroptosis pathway, including the interactions between GSH, PUFAs, and iron ions. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Drugs such as IM and vorinostat may also enhance anti-tumor effects by modulating ferroptosis-related pathways The xc antiporter consists of SLC7A11 (xCT) and SLC3A2 subunits, which exchange extracellular cystine for intracellular glutamate . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | These transporters are crucial in regulating redox balance, iron metabolism, and susceptibility to ferroptosis. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Targeting GPX4 or SLC7A11 has emerged as a promising strategy to sensitize GIST cells to chemotherapy via ferroptosis induction. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Nevertheless, issues such as treatment specificity and resistance remain challenges for future clinical applications. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | In addition to GPX4 and SLC7A11, ferroptosis is modulated by proteins involved in iron homeostasis, such as hepcidin and ferritin, which control intracellular iron availability . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Increasing evidence highlights ferroptosis as a novel therapeutic avenue, especially in tumors unresponsive to conventional chemotherapy or targeted therapy. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Agents like RSL3 activate ferroptosis pathways and effectively inhibit tumor cell proliferation . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | However, the context-dependent nature of ferroptosis and its specific regulatory mechanisms in different tumor types warrant further investigation. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | The redox state of intracellular iron significantly influences cellular sensitivity to ferroptosis. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Additionally, the cytoskeleton, modulated by phosphorylation of heat shock protein family B member 1 (HSPB1), plays a role in iron uptake and lipid ROS generation . |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Before the introduction of IM, inhibitors of HSPs attracted attention as potential therapeutics. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | For example, the HSP90 inhibitor IPI-504 was shown to induce KIT degradation, suppress cell proliferation, and reduce tumor burden, highlighting its clinical potential. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Since HSP family members may also modulate ferroptosis, further investigation is warranted into their role in GIST ferroptosis. |
PMC12065685 | Regulatory roles of non-coding RNAs in programmed cell death pathways and drug resistance in gastrointestinal stromal tumors | Ferroptosis has recently emerged as a therapeutic strategy and prognostic marker in GIST. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.