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PMC11190538
The 50 % cytotoxic and growth inhibitory doses were calculated using the mean dose-response curves of three different experiments (Fig. 3).
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PMC9429973
Infections were reported in 47%/34% (grade 3/4: 7%/9%) of patients.
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PMC8481254
In addition, YAP knockdown prevented the increase in cell O-GlcNAcylation caused by overexpression of CDK19.
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PMC9429973
The study results indicate a meaningful clinical efficacy of the combination.
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PMC10996034
Furthermore, these results confirmed the reliability of PPI network analysis to examine the interactions between proteins, and provided molecular information that the three targets may participate in the drug resistance mechanisms of EOC.
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PMC2614416
Additionally, they afford improved reproducibility, ease of application of quantitative techniques and controlled experimental conditions.
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PMC11653168
Increased expression levels of both cleaved caspase-3 and LC3B markers of apoptotic and autophagic cell death suggested a dual mechanism regarding the promotion of cell death by Stattic.
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PMC11678130
Finally, the present study also assessed the potential irritant effect and the antiangiogenic properties of the QUE + 5-FU treatment in ovo.
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PMC9895440
Read quality was assessed with the FastQC tool (version 0.11.5).
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PMC10761571
Fatemeh Akbari: Writing - original draft, Resources.
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PMC11471176
Our team succeeded in synthesizing, characterizing, and experimentally validating one of these compounds; namely LMS1007 (data yet to be published).
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PMC7215722
As shown in Figure 2, after 2 h incubation with EB, the concentration of EB significantly and rapidly increased under DSS treatment.
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PMC9429973
According to population databases (1000 genomes; ExAc; gnom AD), 11 mutations were pathological, 3 probably pathological and 2 of uncertain clinical significance.
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PMC10933092
The RNA concentration of each sample was determined using a NanoDrop 2000 (Thermo Fisher, United States).
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PMC11306019
Various mechanisms have been identified in relation to the resistance and relapse of MM patients treated with BTZ (Gonzalez-Santamarta et al., 2020).
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PMC9960565
The Hg concentration in the supernatants was calculated using the standard curve.
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PMC10631132
3Analysis of cell-forming complexes following mesodermal differentiation using CLSM.
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PMC11621493
This family is characterized by a catalytic domain structurally similar to the plant lipid hydrolase patatin (patatin-like domain).
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PMC11594588
Heart muscle cells, cardiomyocytes, show a significantly higher concentration of mitochondria in relation to other types of cells .
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PMC7338939
Cells were incubated at 37°C, 5% CO2.
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PMC9429973
p53 status was analyzed by immununohistochemistry using an anti-TP53 antibody (clone: DO-7).
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PMC11764090
Overexpression of ZjICE2 improves chlorophyll content, photosynthetic efficiency, and cold resistance injapanese lawngrass (Zoysia japonica Steud.) (
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PMC7802142
It is also demonstrated that miR-100 promotes MSC osteogenesis .
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PMC11537649
Lnc NEAT1 = long noncoding nuclear enriched autosomal transcript 1, qRT-PCR = quantitative real-time PCR.
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PMC10938336
In vitro cytotoxic assays were carried out in HL-60 and BJ cells using the MTT assay along with analysis of apoptosis with the annexin V detection kit.
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PMC10933092
The thermal cycling program included the following steps: 50°C for 2 min, denaturation at 95°C for 2 min, followed by 40 cycles of 95°C for 15 s and 60°C for 1 min.
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PMC11321678
First, the cutadapt tool was used to identify and trim any adapter sequence in each read, and then, BWA was used to align trimmed reads pair to hg19 reference.
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PMC11291490
DuPBMCs were obtained from 30-day-old ducks or ducks that had been vaccinated at 5 w post the initial vaccination using the peripheral blood mononuclear cell separation kit (Tianjin Hao Yang Biological Products Technology Co., Ltd., Tianjin, China) following the manufacturer’s protocols.
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PMC11787355
Constant regions of TCR α and β chains were murinized to avoid mispairing with endogenous human TCRs.
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PMC11705547
Disrupting the interaction between PD-1 and PD-L1 neutralizes the inhibitory signals in T cells, and activates the anti-tumor immune response .
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PMC10813895
Interestingly, ELF5 knockout and heterozygote female mice failed to produce milk during their first gestation, but ELF5 heterozygote females regain the milk production after second or third gestations .
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PMC11171319
All in all, HCMV fulfils the recently described four hallmarks of cancer in transformed cells , in addition to the previously reported ten hallmarks of cancer (Figure 1).
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PMC11412721
Together, these data suggested that p53-AS isoforms may not be required to control the pool of early B cells under normal conditions, but that in an Eμ-Myc context they would limit the expansion of pre-tumor early B cells, specifically in males. (
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PMC11629143
not significant (test).
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PMC10047551
In this study, we found that the PD-L1 DNA methylation status functionally influences its expression.
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PMC11422497
The statistical analysis revealed no significant correlation between circ_SMA4 and the following clinicopathological features: age, gender, tumor size (cm), mitotic figure (HPF), or malignant degrees and type, as well as gene mutation status (P > 0.05).
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PMC11594641
We observed a decrease in the migration of RAB27A KO DMBC12 and RAB27A KO SkMel28 cells compared to controls.
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PMC4443654
Close examination of these regions reveals many examples of enhancer activity nucleated upon genes associated with cell-type-specific biology (Figure 5A, Additional file 1: Figure S10).
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PMC11787381
p < 0.05 vs. Aβ1-42 was considered significant (red).
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PMC10213199
Total RNA was extracted from the larvae, adult flies, and cells using TRIzol reagent (Invitrogen, Carlsbad, CA, USA) according to the manufacturer's instructions.
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PMC7039683
The large majority of embryos with SNP1 constructs, of either allele, were not blue, and no two blue embryos showed the same pattern.
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PMC11001582
We then used CRISPR–Cas9 to insert these repeats, or a control eGFP sequence, immediately after, and in frame with, the endogenous mouse C9orf72 ATG start codon, in mouse embryonic stem cells (Extended Data Fig. 1a).
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PMC6337547
At the same time, the total radical reducing activities of the seven phenolic acids were determined to be consistent with the above results .
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PMC11588008
The expression of ERK mRNA. ***
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PMC9429973
Image: Summary/Conclusion: Aside from the significant elaboration of HCT technology, most worthy of mention developments include the success in haploidentical HCT and the use of reduced-intensity conditioning in older patients.
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PMC7039683
Embryos were dechorionated using pronase (Sigma, St. Louis, MO, 1 mg/mL in fish water 1 mg/mL in fish water) at room temperature for 10 min, rinsed in PBS, and then dissociated cells using a pestle and incubated in trypsin (0.25%)-EDTA (Life technology) at 33°C for 30 min.
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PMC11799978
Schematic graph of the coculture system assessing the effects of tumor CM on fibroblasts. (
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PMC11180402
Predicted transcription factor-binding sites in the SNHG1 promoter. (
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PMC11782780
WB results also demonstrated that the addition of glycolysis inhibitors 2-DG or 3-BP weakened the upregulation of sh-EBF3 knockdown on BC cells and the expression of stem cell markers (CD133, CD44, and Oct-4) (Fig. 3G).
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PMC11001582
Several mouse models have been developed to elucidate pathomechanisms associated with C9ALS/FTD pathology.
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PMC11607321
Through manual exploration, the optimal number of factors was set to 100, which was automatically reduced during training to 97 by discarding factors with variance explained lower than 0.0001.
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PMC11269933
Moreover, the calculation of enzyme-substrate binding affinity by MM/GBSA method showed that the binding free energy in the S11 phosphorylated system is lower than that in the wild-type system (ΔGbind; Figures 3E and 3F).Table 1Properties of the formed hydrogen bonds between PEP/ADP and its adjacent PK residuesH-BondWide Type SystemS11-Phospho SystemOccupancy(%)Distance(Å)Angle(Å)LifetimeOccupancy(%)Distance(Å)Angle(Å)LifetimeUNK_591@O2-ARG_86@HH2217.372.85154.9114.3310.572.89159.685.76UNK_591@O3-ARG_86@HH1210.872.77158.08186.372.81161.7418.04UNK_591@O5-ASN_88@HD2229.32.89155.7934.3319.372.9156.098.9UNP_592@O6-LYS_124@HZ32.072.86156.992.331.732.86153.421.1UNP_592@O8-LYS_124@HZ22.62.82150.852.338.272.78156.361.3UNP_592@O8-LYS_124@HZ32.932.71155.973.678.82.77154.541.33UNP_592@O9-LYS_124@HZ22.32.82152.432.673.972.78155.991.34UNP_592@O9-LYS_124@HZ32.432.78151.6433.672.78157.971.58UNP_592@O10-LYS_124@HZ13.932.77161.715.675.932.76153.761.38UNP_592@O10-LYS_124@HZ22.92.79155.5545.572.75156.881.41UNP_592@O8-LYS_215@HZ11.572.79159.9221.032.79149.091.39UNK_591@O6-LYS_376@HZ30.52.7163.3110.82.79161.971.07UNK_591@O2-ARG_86@HH1212.572.88154.0233––––UNK_591@O3-ARG_86@HH2215.42.88147.8812.67––––UNK_591@O6-ASN_88@HD2192.95153.315.33––––UNK_591@O6-ASN_88@HD221.22.95155.086.67––––UNK_591@O5-SER_90@HG5.92.78161.289.33––––UNP_592@O6-LYS_124@HZ11.632.8152.262.67––––UNP_592@O9-LYS_124@HZ12.772.81155.932.67––––UNP_592@O6-ARG_129@HH121.072.92152.74.33––––UNP_592@O8-ARG_129@HH2216.672.87153.4223––––UNP_592@O9-ARG_129@HH128.772.87152.9924.67––––UNP_592@O10-ARG_129@HH2234.572.82154.4455––––UNP_592@O4-LYS_215@HZ20.272.97152.921––––UNP_592@O7-LYS_215@HZ11.532.85153.662––––UNP_592@O7-LYS_215@HZ31.732.78157.172.67––––UNP_592@O9-LYS_215@HZ21.52.83162.22.33––––UNP_592@O9-LYS_215@HZ31.12.76154.971.67––––UNP_592@O10-LYS_215@HZ22.732.81162.172.67––––UNK_591@O1-ASN_88@HD22––––1.672.9143.81.4047UNK_591@O5-ASN_88@HD21––––14.072.98155.092.0635UNP_592@O6-LYS_124@HZ2––––1.12.86150.771.1196UNP_592@O7-LYS_124@HZ1––––2.132.85153.921.1020667UNP_592@O7-LYS_124@HZ2––––2.32.83152.271.146UNP_592@O7-LYS_124@HZ3––––2.032.83154.741.125UNP_592@O8-LYS_124@HZ1––––7.932.76154.711.3321667UNP_592@O10-LYS_124@HZ3––––5.472.76154.791.2751667UNP_592@O7-ARG_129@HH21––––12.332.87154.023.5956667UNP_592@O6-LYS_215@HZ2––––2.332.84157.951.5769333UNP_592@O8-LYS_215@HZ2––––1.12.8156.311.1938333UNP_592@O10-LYS_215@HZ1––––1.332.79155.11.0663667UNP_592@O10-LYS_215@HZ3––––1.472.76158.941.0802UNP_592@O6-LYS_233@HZ1––––3.932.84153.461.0701667UNP_592@O6-LYS_233@HZ2––––3.872.91156.61.1028667UNP_592@O6-LYS_233@HZ3––––3.972.81156.011.1752333UNP_592@O7-LYS_233@HZ1––––5.972.88153.591.2039333UNP_592@O7-LYS_233@HZ2––––6.232.84150.941.0967UNP_592@O7-LYS_233@HZ3––––6.12.84153.41.4685UNP_592@O8-LYS_233@HZ1––––32.81154.861.3177333UNP_592@O8-LYS_233@HZ2––––2.82.78155.851.4041333UNP_592@O8-LYS_233@HZ3––––3.12.83156.011.4102UNP_592@O9-LYS_233@HZ1––––1.632.79156.041.0984UNP_592@O9-LYS_233@HZ2––––1.772.84154.621.6135333UNP_592@O9-LYS_233@HZ3––––1.532.79154.031.0877UNP_592@O10-LYS_233@HZ1––––5.472.81154.381.2676667UNP_592@O10-LYS_233@HZ2––––6.032.78155.431.3307333UNP_592@O10-LYS_233@HZ3––––5.672.81155.21.3040667UNK_591@O2-LYS_279@HZ1––––4.172.9150.191.1162667UNK_591@O2-LYS_279@HZ2––––4.22.88151.451.1855UNK_591@O3-LYS_279@HZ1––––2.532.77160.871.2673UNK_591@O3-LYS_279@HZ2––––2.532.82165.291.2531UNK_591@O3-LYS_279@HZ3––––2.432.86155.521.2993333UNK_591@O4-LYS_279@HZ1––––3.32.83155.81.3571333UNK_591@O4-LYS_279@HZ3––––3.372.76156.451.1909667UNK_591@O2-SER_371@HG––––7.432.63163.677.8377333UNK_591@O3-SER_371@HG––––6.472.66161.4813.8869UNK_591@O4-SER_371@HG––––10.672.63162.248.6064667 Properties of the formed hydrogen bonds between PEP/ADP and its adjacent PK residues Subsequently, the SPR experiments were conducted to validate the results of molecular dynamics simulations and the impact of S11 phosphorylation on enzyme-substrate affinity.
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PMC11798926
For mouse cultures, hippocampal neurons were dissected from wild-type P0 C57BL/6J mouse pups of both sexes and plated in 6-well plates at a density of 100,000 cells per well.
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PMC9429973
Results: Sixty-nine lymphoma patients, treated with two vaccine doses, were included in this study.
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PMC11672142
This assessment is supported by consulting the SwissADME Web site.
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PMC11726183
All the mentioned modules used are available from Drug Discovery Package, Schrödinger, Inc., New York, USA (2024) software.
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PMC9429973
Aims: Our study aims to evaluate the Overall Survival (OS) of all the refractory/relapsed Chronic Lymphocytic Leukemia patients treated with Ibrutinib in the third line of therapy from 2018 until january 2022 and evaluate the correlation of this survivance with the age subgroups and gender.
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PMC11700165
Cells expressing TEL-SYK showed stronger oncogenic capacity, as measured by rapid closing of the gap and greater proliferation and migration rate compared to ITK-SYK and BTK-SYK (Supplementary Figure S2A,B).
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PMC10551595
GinA5 = 5 μM GinA. Regardless of the type of ALL, the inhibitory effect of the GinA and Dexa combination was examined on the primary cells of nine patients to ascertain the prevalence of combination therapy.
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PMC11401350
Data are summarized as a histogram in (C) as mean (SD, n = 7).
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PMC11049548
The ambiguities were solved using spiking experiments.
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PMC11753949
The contributions of synaptopodin and synaptopodin neighbors to these steps, remain open questions in neuronal cell biology.
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PMC11678841
After 24 h of culture, media were removed and fresh complete media (100 µL), containing increasing concentrations of α-TOH or GA (1, 5, 10, 25, 50, and 100 µM) were added; then, cells were incubated in a humidified 5% CO2 atmosphere at 37 °C for 4, 24, and 48 h. Cells maintained in medium supplemented with DMSO or ethanol (EtOH) were used as controls.
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PMC5916734
When generating the 3B12- 86 cell line, changes in the copy number of the human FIX gene were revealed: the copy number of the FIX gene increased approximately fivefold after amplification, remained constant upon cloning of the amplified population, and subsequently dropped fourfold after plasmids had been cotransfected with the auxiliary genes and repeated cloning had been performed.
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PMC11286266
This might reflect essentiality of the genes involved or redundancy amongst them.
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PMC11545737
While inflammation due to macrophage pyroptosis has been extensively addressed, the effects of activation of pyroptosis pathways on modulation of cell cytoskeleton and cell–cell junctions in epithelia and endothelia and on the bacterial crossing of epithelial and endothelial barriers have only been partly investigated.
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PMC9429973
This study included 4103 annual check-ups with available HJB score and all other biological parameters: Hb, HbA%, HbS%, HbF%, platelets etc.
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PMC9874064
Kaplan-Meier analysis of overall survival probability in LIHC patients.
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PMC10957991
Magnifications of the stainings, related to (A).
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PMC11806182
The most significantly altered genes were predominantly up-regulated, including AURKA, ABHD3, NCAPG, YARS, RRM2, AUNIP, and MTFR2 (Fig. 5B).
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PMC9429973
The mean time from mobilization to HSC transplantation was 3.3 months (0-11).The median age was 52 years (11-66) with a sex ratio of 1.4.
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PMC11434983
The capability of the new complex to target EGFR and inhibit its phosphorylation was tested using the Western blotting technique, as previously described .
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PMC11593713
Growing medium was removed from each well and collected in 15 mL sterile centrifuge tubes.
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PMC8996378
It would also important to assess the ability of these compounds to modulate other ABC transporters involved in MDR, namely ABCC1 and ABCG2.
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PMC8343815
In a study conducted by Chithrani and colleagues, they evaluated the radiosensitizing effects of 50-nm gold nanoparticles on HeLa cells and found that gold nanoparticles in combination with 6-MV X-ray enhanced radiotherapy by a factor of 1.17 .
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PMC11718274
14.94 and 28.89 µg/ml) for 72 h. Integrity of mitochondrial membrane potential studied using Rhodamine-123 dye in the control untreated A-431 cells and A-431 cells treated with doxorubicin- or Y 2 O 3 NPs (7.47.
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PMC5673060
Annotation enrichment analysis of phosphoproteins up-regulated in either the DasR or A204 parental cells compared against the human genome using the DAVID application.
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PMC11740573
In the study of Mohanty S et al. it was shown that vitamin D induces the expression of tight junction proteins during bacterial infection .
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PMC9429973
The suitability of these studies for indirect treatment comparison (ITC) was assessed by considering the comparability of study design, population, intervention, and outcomes.
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PMC11075223
Xuanshen Shengma Decoction, combined with compound oxygen, reduced the inflammatory reaction of chronic cough in children and improved lung function .
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PMC10452486
In light of these findings, we revisited the literature on HLA-E expression on human cancers and summarized the reports that used the MEM series of mAbs in Table 2.
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PMC7917457
Systemic tumor-specific T cell responses were analyzed with the ELISpot assay from the spleens of treated mice.
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PMC6600592
The reaction was then kept on room temperature for 6 h. After the reaction was stopped, icy aqueous hydrochloric acid solution (0.1 mol/L, 10 mL) was drop to resultant solution under stirring for 10 min.
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PMC11791203
Fluorescence microscopy of HT29 cells treated with the chloroform extract of H. malabarica revealed distinct staining patterns upon dual staining with acridine orange (AO) and ethidium bromide (EB), demonstrating apoptosis induction in a concentration-dependent manner (Fig. 3).
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PMC11657744
Cells were fixed and stained with antibodies against PCNA (red), Arl13b (green), and DAPI (blue) for nuclear staining.
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PMC11247842
The data collection and methodology for post-GWAS is a unique resource for livestock genetics research.
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PMC9429973
For acute GvHD, the risk decreased over time (p = 0.004), ranging from a 1-year cumulative incidence of 42% (95% CI: 26–62%) in 2000 to 26% (95% CI: 19–34%) in 2020, whereas the risk of chronic GvHD remained stable (p = 0.49), with a 2-year cumulative incidence of 49% (95% CI: 45–53%) in the full cohort.
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PMC11472639
The effects of exercise on NK-cell subsets in MREM participants can be seen in Supplementary Table 3.
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PMC11637284
Moreover, over-replication of kDNAs in the few cells that have retained the kDNA was also observed (Fig 4B, right panel and 4C, middle panel).
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PMC11724582
B-C) Colony formation was detected via a colony formation assay. (
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PMC11306331
Cells were then expanded for sorting.
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PMC11119602
Interestingly, both parental and HepG2/cr grew at similar rates following subsequent incubation (Figure 1F), an effect not seen in scratch test assays (Figure 1G).
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PMC11024707
No significant difference was found between the sibling and control groups in terms of mi-RNA-151a-3p.
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PMC9812014
Furthermore, no detectable loss in cell viability was detected at HHT doses less than 1 µM. HHT also exerted a strong inhibitory effect on NDV by lowering the level of NDV-NP protein expression in cells treated with 50 nM HHT.
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PMC11388384
Alternatively, SCUBE1 could promote SHH secretion or diffusion within the cell layer (Fig. 3E).
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PMC9429973
Lancet.398(10299):491-502.
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PMC11742231
Similarly, the CCLE dataset, after preprocessing, contained 11,104 drug–cell pairs involving 23 drugs and 436 cell lines.
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PMC11775197
15-lipoxygenase-1 (15-LOX-1) expression is associated with NSAIDs, and its main product of metabolism, 13-S-hydroxyoctadecadienoic acid (13-S-HODE), promotes the apoptotic pathway by down-regulating PPARβ/δ expression .
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PMC10551595
The TPSA for this compound was estimated at 75.99 Å, which indicated a significant permeability (<140 Å) of any cellular plasma membrane for this derivative.
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PMC10440586
Gliomas are the most prevailing central nervous system (CNS) tumors, accounting for approximately 80% of brain malignancies.
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