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The cloudsat 2cice product describes the vertically resolved microphysical properties of ice clouds [deng et al ., 2010, 2013]. The algorithm is a synergetic ice cloud retrieval derived from the combination of the cloudsat radar reflectivity (ze) and the cloudaerosol lidar and infrared pathfinder satellite observation ... |
Cough variant asthma (cva), a variant form of classic asthma that presents solely with a cough and responds to bronchodilator treatment, is considered to be the most common cause of chronic coughs . Several studies have suggested that the fundamental pathophysiological characteristics of cva, airway inflammation and ai... |
Childhood obesity is related to a wide range of psychosocial and physical problems resulting in larger health care costs [2, 3]. Since obesity, once established, is difficult to treat, prevention is the main priority and is therefore receiving increasingly more attention . Traditionally, the prevention and treatment of... |
Only 10% to 20% of tumors are resectable at the time of diagnosis, and even in these patients, survival beyond 5 years can be anticipated in no more than 10% . These data underscore the importance of an optimal palliation that will guarantee the shortest possible hospital stay and as long a survival as possible with a ... |
The question of why one person develops high blood pressure (bp) and another does not has long been controversial . For example, freud in the 1930s hypothesized that keeping one's anger in will cause bp to rise . Theories of stress and disease came a bit later, and a multitude of experimental and field studies show tha... |
Participants aged between 4 and 50 years with type 1 diabetes on insulin pump therapy with impaired awareness of hypoglycemia participated in a 6-month intervention trial comparing standard pump therapy (insulin pump only) to the veo (insulin pump with continuous glucose monitoring and lgs function). Hypoglycemia aware... |
Transepithelial elimination of granulomas has been reported in the past; however, transfollicular elimination has not found a mention in the dermatologic literature . Herein we report this curious phenomenon and correlate it with the clinical features of this condition . A 43-year - old male presented with an asymptoma... |
Improved treatment strategies and better supportive care have resulted in increased survival rates for most childhood cancers . Currently, close to 80% of children and adolescents with cancer will survive 5 years or more after diagnosis . In the usa, they are at risk for developing secondary neoplasm, cancer recurrence... |
A 55-year - old woman was referred to our institution with sudden onset of chest pain . She had a history of percutaneous vertebroplasty at the 12th thoracic vertebra for osteoporotic fracture 3 weeks before she was referred to the institution . An electrocardiogram (ecg) did not show st - segment elevation; sinus rhyt... |
The study protocol was reviewed and approved by the ethical committee of the barcelona health institute . During the 200910 influenza season, the sentinel network of primary care physicians and pediatricians of navarre obtained nasopharyngeal swab specimens from patients with influenza - like illness (ili) for virologi... |
Fine needle aspiration cytology (fnac) of the thyroid gland is firmly established as a first - line diagnostic test for the evaluation of goiter and as the single most effective test for preoperative diagnosis of lesions of the thyroid gland . Recent studies have also confirmed that fnac is more sensitive as well as sp... |
Hemoptysis is one of the symptoms of pulmonary diseases such as parenchymal diseases (like infections) and endobronchial lesions (like tumors) as well as vasculitis (like wegener s disease and anti - glomerular basement membrane disease). Based on its severity, hemoptysis is classified as mild, moderate, and severe . M... |
According to the 2010 national survey on drug use and health, 20 percent of us adult population (45.9 million) were estimated to have mental illness in 2010: 3.8 percent had suicidal ideation (8.7 million); 20 percent of the general population (9.2 million) with mental illness met criteria for substance abuse or depend... |
Metabolic syndrome (syndrome x, insulin resistance syndrome) consists of constellation of metabolic abnormalities which include central obesity, hyperglycemia plus insulin resistance, high triglycerides plus low hdl cholesterol, and hypertension (the deadly quartet). Third national health and nutrition examination surv... |
A left renal vein passing behind the abdominal aorta is termed a retroaortic left renal vein (rlrv), and this anomaly is a relatively uncommon condition . Recent advances in computed tomography and magnetic resonance imaging techniques make it possible to visualize the vascular structures in detail . Additionally, the ... |
Over the past few decades, percutaneous coronary intervention (pci) has become one of the most common medical procedures for patients with coronary artery disease . The benefits of pci are mainly attributable to a reduction of myocardial ischemia . However, noninvasive tests of myocardial ischemia are limited by their ... |
Lack of effective cancer treatments and the emergence of drug resistance in progressively growing tumors make cancer immunotherapy a viable alternative to treat and manage metastatic diseases . Synthetic peptide - based vaccines that are capable of inducing specific t cell - mediated immunity are emerging as attractive... |
The use of natural and artificial substances has increased during the past few decades, which indicates the incidence of a new problem in physical and social health . The term addicted individual can be defined as one who has a very strong desire toward the use of addictive substances, regardless of their consequences ... |
Clinical reasoning (cr) is one of the most crucial competencies that a physician should achieve . Most of specialty societies, licensing bodies and medical schools consider it in the list of competencies that their graduates should attain and they try to ensure its mastery in the learners . Many factors may influence (... |
Cutaneous t - cell lymphoma (ctcl) is a rare group of mature t - cell lymphomas primarily presenting in the skin . Between 2000 and 3000 new cases of ctcl occur in the us each year, with mycosis fungoides (mf) being the predominant subtype.1 skin manifestations of mf include patches, plaques, tumors, and erythroderma .... |
Proton pump inhibitors (ppis) are a class of drugs that are routinely used in children; however, stability data for extemporaneous liquid formulations are not readily available for many of these compounds . In a prospective study performed by lugo et al ., which included 21 children's hospitals, an oral suspension of l... |
Chronic obstructive pulmonary disease (copd), a disorder of chronic airflow limitation (chronic airflow obstruction) not reversed by bronchodilators, is now the 3 commonest cause of death worldwide . While most of the information on copd prevalence, morbidity, and mortality is available from high - income countries, it... |
Darier's disease (dd), described independently by darier and white in 1889, is an autosomal - dominant disease characterized by persistent eruption of hyperkeratotic papules, histological examination of which shows suprabasal acantholysis with distinct overlying dyskeratosis . Dd is caused by mutation in the atp2a2 gen... |
Uterine rupture rarely occurs during pregnancy, but it is a critical obstetric complication associated with maternal and fetal mortality and morbidity.1 it is known that the rate of uterine rupture increases in patients with a history of uterine surgery, such as cesarean section or myomectomy . It is however, not yet k... |
Tracheoesophageal fistula (tef) is a congenital or acquired life threatening complication of a communication between the esophagus and the tracheobronchial tree or the other mediastinal structures, due to pathological conditions affecting these structures . The most common etiology of nonmalignant acquired tef is a cuf... |
Inguinal hernia repair is one of the most commonly performed surgical procedures with approximately 20 million inguinal herniorrhaphies repairs performed yearly around the globe . The operative approach to inguinal herniorraphy overtime has evolved from primary tissue - based repairs to open tension - free mesh repairs... |
Les indices de pharmacorsistance (ipr) quantifient leffet cumulatif de la rsistance antimicrobienne sur la probabilit quun pathogne donn soit susceptible un traitement antimicrobien . Driver lipr des infections urinaires dorigine non nosocomiale causes par lescherichia coli en colombie - britannique entre 2007 et 2010 ... |
Stroke is the major cause of chronic disability and the third leading cause of death in humans after cancer and coronary heart disease in developed countries . Because stroke causes severe neurological complications, new strategies for patients suffering from stroke are needed . The capacity for neuroprotection depends... |
Rising interest in health and regular medical checkups have promoted detection of early cancer . Likewise, in stomach cancer, detection rates for early stages are higher than those for progressive cancer . Traditionally, gastrectomy has generally been regarded as the standard therapy for treatment of gastric cancer . H... |
Worldwide, more than 4 million people each year are estimated to have a non - st - segment elevation myocardial infarction (nstemi), and long - term mortality is higher in patients with non - st - elevation acute coronary syndrome (acs) than in those with st - elevation acs . In clinical practice, for patients who pres... |
Surgery for pancreatic cancer is probably the most demanding and risky operative procedure in abdominal surgery . Remarkable progress has been achieved during the last three decades and pancreatic surgery can nowadays be performed safely with low morbidity and mortality in various specialized hospitals around the world... |
Benzo[a]pyrene (b[a]p), a polycyclic aromatic hydrocarbon compound, is produced by incomplete combustion of organic compounds and high - pressure processes . This compound is commonly present in motor vehicle exhaust, tobacco smoke, grilled, smoked and broiled foods, and emissions from residential and industrial heatin... |
Ectodermal dysplasia, as first described by thurman,1,2 is a hereditary disorder occurring as a consequence of disturbances in the ectoderm of the developing embryo . The triad of nail dystrophy (onchodysplasia), alopecia or hypotrichosis (scanty, fine light hair on the scalp and eyebrows), and palmoplantar hyperkerato... |
Chronic renal failure is a progressive, irreversible kidney disorder in which the body s ability to maintain liquid and electrolytes is lost; it is considered a major problem in the health system, and is one of the leading causes of death and inability worldwide (1). The prevalence of chronic renal failure is 242 cases... |
Curing a medical disease generally implies completely removing the pathogenic agents: e.g., killing microbes with specific antibiotic therapy or surgically removing cancer . In t1d, cure implies reversing new - onset t1d and restoring glucose homeostasis . Initial surgical success using the edmonton protocol in islet t... |
Of all the functional groups in organic chemical space, the olefin must be regarded as one of the most privileged from the vantage point of utility in synthesis . As a result, methods for olefin synthesis and functionalization have been extensively developed and applied in both academic and industrial sectors . Most ol... |
Juxtaglomerular cell tumor (jgct), also known as reninoma, is an extremely rare kidney tumor of the juxtaglomerular cells that typically secrete renin . It was first described, in 1967, by robertson et al ., and was first named, in 1968, by kihara et al . Since then, approximately 100 case reports have been published .... |
Preterm birth (ptb) is a leading cause of neonatal morbidity and mortality, and it is well recognized that the risk decreases with increasing gestational age of delivery . The benefits of antenatal corticosteroid (acs) administration to patients at risk of delivery <34 weeks to mitigate the risks of prematurity have be... |
Porcelain - fused - to - metal (pfm) restorations are the most commonly used crowns due to high strength and accuracy of the cast metal and esthetic properties of the porcelain . Factors affecting the bracket bond strength to enamel have been extensively studied and include enamel surface preparation techniques, adhesi... |
The study was approved by the medical ethics committee of jinling hospital and adhered to the tenets of the declaration of helsinki . All donor tissues were obtained within 12 h after enucleated eyeballs from healthy young adults with accidental death without any disease . Twenty eyes of 17 patients, who are with moder... |
Central retinal artery occlusion (crao) leads to severe visual disturbances and is generally resistant to treatment . The fundus changes are characterized by retinal whitening, a cherry red spot, and a pale disc.1 the visual prognosis in eyes with crao is generally very poor, and the degree of visual damage has been su... |
Neurodegenerative disorders represent a global health problem, being a major cause of high mortality among elderly populations . One of the most common degenerative diseases of the nervous system is parkinson's disease (pd). It is related to the death of dopaminergic neurons in the basal ganglia of the brain . Regardle... |
This evaluation illustrated that without the implementation of an appropriate scaling system, the work - up to rule out pe is of low yield . Consequences of excessive testing include unnecessary exposure to radiation and financial wastefulness . The implementation of clinical prediction rules will improve the diagnosti... |
A study conducted in a saudi hospital assessed the opinion of nurses on self report of pain as the indicator of pain intensity revealed that nurses underestimated pain intensity in smiling patient and overestimated it in the grimacing patient (kaki et al . (2000) conducted a survey of nurses' decisions about assessment... |
Birth weight is dependent on several parameters, the chief being the gestational age at delivery . Of the non - pathological variables, maternal ethnicity, height, and weight, as well as parity definition of small for gestational age baby depends on accurate criteria for expected mean weight and standard deviation . Co... |
A 30-year - old man was admitted to our clinic with complaints of abdominal pain and fever . He had a history of ewing's sarcoma diagnosed 18 months earlier on his chest wall and he had undergone pneumectomy with negative excision margins, followed by chemotherapy . On physical examination, his saturation was 91% despi... |
In mid - april 2010, influenza - like illness was reported in pigs in a north yorkshire gilt (female pig intended for breeding that has not farrowed) grower unit of 1,200 animals . Gilts were brought into the unit in batches of 100 animals at 5 months of age . The first batch of gilts arrived in mid - january 2010; pre... |
Recurrence of bladder cancer is common, and is reported to occur in 50%-70% of cases, and approximately 10%-15% of patients will experience disease progression . Detection of bladder cancer when it is still at an early stage is important for effective treatment, and currently the standard approach in detection of bladd... |
Recent years have seen the development of a new class of implicit - solvent models the variational implicit - solvent model (vism). Coupled with the robust level - set numerical method, such models allow an efficient and quantitative description of molecular solvation . Central in the vism is a mean - field free - ener... |
Lichen planus (lp) is a chronic dermatologic disease that is relatively common among our population . It is most common among middle - aged adults with women predominance (3:2) ratio over men . This article focuses on the prevalence of oral, skin, and oral and skin lesions of lp . A study was conducted in the departmen... |
Diabetes is one of the most common disorders worldwide, and its prevalence is estimated to increase by 122% from 1995 to 2025 (1). Due to the increasing prevalence of diabetes, factors related to diabetes and its complications have become increasingly important (2, 3). Appropriate care, including controlling blood suga... |
Androgenic alopecia (aga) is the most common hair loss condition in men and women with significant negative impact on their social and psychological wellbeing . Aga, a hereditary androgen - dependent disorder, is characterized by a progressive process that causes a gradual conversion of terminal hair into miniaturized ... |
Oral contraceptive - induced menstrual migraine (ocmm) is a menstrual migraine subtype mainly caused by estrogen withdrawal occurring during the week of pill suspension [1, 2]. Ocmm is a poorly studied, but particularly severe and disabling form of menstrual migraine; it is codified by the ichdii classification as estr... |
Lichen planus is a chronic inflammatory mucocutaneous disease of unknown etiology that frequently involves the oral mucosa . The disease affects skin and mucosa in prevalence estimated between 0.5 and 2.0% of the population with predilection for females and a mean age at onset in the fourth or fifth decade 1 . About ha... |
Cerebral venous and sinus thrombosis is a rare condition accounting for <1% of all strokes.7) its annual incidence is estimated at three to four cases per one million members of the population, most often affecting young adults and children.19) in adults, the peak incidence is in their third decade, and approximately 7... |
Myofascial release has been commonly regarded as a therapeutic, post - exercise technique aimed towards repair and recovery (1, 2, 18, 22). More recently, myofascial release has been regarded as a performance enhancing, pre - exercise technique within the athletic population (19, 24). This current pre - exercise myofas... |
Severe hyperkalemia during orthotopic liver transplantation, is very dangerous, and needs vigilant monitoring of serum potassium and acute management of the hyperkalemia . The causes of hyperkalemia during different stages are; 1) extracellular shift in exchange for h during severe metabolic acidosis in an - hepatic ph... |
Human saliva is a biological fluid with myriad of biological functions important for the maintenance of oral and general health . It is a plasma ultra - filtrate containing proteins either synthesized in situ from blood or in the salivary glands 1 . Major salivary glands consisting of submandibular glands, sublingual g... |
Vitamin k is a fat - soluble vitamin existing mostly in nature and comprises vitamin k1 (phylloquinone), contained mostly in deep green vegetables, and vitamin k2 (menaquinone), found mainly in meats, dairy, fish, and fermented foods . The classic role of vitamin k is as a cofactor for the enzyme gamma - glutamyl carbo... |
Ehlers danlos syndrome (eds) is a group of inherited connective tissue disorders caused by a defect in collagen synthesis . The clinical presentation varies widely based on the type of eds.1 joints, skin and blood vessels are typically affected, the latter being the problem in the case presented in this paper . Some ty... |
The philippine archipelago, consisting of about 7107 islands, is a center of endemicity and biodiversity where a large number of endemic plants have been reported to exhibit medicinal properties . Previous ethnobotanical studies of medicinal plants in this country were conducted in the archipelagos of batanes and visay... |
Among the different human cell types, janus kinase (jak)/signal transducer and activator of transcription (stat) signaling cascades transduce signals of more than 50 cytokines and peptide hormones . A subset of these growth factors such as prolactin (prl), growth hormone (gh), leukemia inhibitory factor (lif), and onco... |
Endothelial injury has been studied in septic and non - septic patients, both at risk for and with established acute lung injury (ali) and acute respiratory distress syndrome (ards). Several clinical studies have demonstrated that circulating levels of angiopoietin-2 (ang-2), which are associated with mortality, are el... |
The prognosis is bleak with the median survival in advanced disease around four months from diagnosis . Survival compares unfavourably with other european countries and the usa [1, 2]. It has often been felt that the scottish lung cancer population has more comorbidity with poorer performance status thus presenting few... |
Atypical antipsychotics are believed to reduce the risk of extrapyramidal syndrome, including tardive dyskinesia (td). Quetiapine is reported to be less likely to induce td side effects and, in fact, has been shown to relieve symptoms of severe td1) and reduce td risk.2) quetiapine's low affinity and fast dissociation ... |
India is estimated to have an adult (1549 years) human immunodeficiency virus (hiv) prevalence of 0.27% in 2011 . Adult hiv prevalence among males and females is estimated at 0.32% and 0.22%, respectively . According to the national aids control organisation (naco) the adult hiv prevalence at national level has continu... |
Diarrhea is an important childhood infection globally, accounting for 2.5 million deaths in under - five children every year . Passage of blood and mucus in stool associated with high - grade fever, tenesmus, and intestinal cramps are common symptoms . Arthritis, conjunctivitis, parotitis, intussusception, rectal prola... |
The standard approach of internal jugular vein (ijv) for central venous cannulation (cvc) using visual and palpable anatomic landmarks is associated with 95% success rate, but it carries the complications from inadvertent puncture of surrounding structures, including the common carotid artery due to significant variati... |
Pioglitazone is an established insulin sensitizer hugely successful in therapeutic management of type 2 diabetes mellitus . The beneficial effects extend beyond glycemic control and have positive effects on lipid metabolism, blood pressure, endothelial function, adiponectin, and c - reactive protein levels . Pioglitazo... |
Chronic helicobacter pylori infection is causally associated with gastritis, gastroduodenal ulcer disease, gastric adenocarcinoma and mucosa - associated lymphoid tissue lymphoma . A genome - wide association study (gwas) of anti - h . Pylori serologic status among europeans identified inverse associations with single ... |
Malignant ascites (ma), defined as the abnormal accumulation of cancer - containing fluid in the peritoneal cavity, is a sign of peritoneal carcinomatosis.1 it is caused by a variety of primary abdominal and extra - abdominal cancers . The former category mainly includes gastric cancer (gc), colorectal cancer, pancreat... |
Blood is a complex tissue consisting of a very specialized network of circulating immune cells and soluble factors that are the morphological substrate of the human immune response . Among immune cells, the monocyte, neutrophil, and natural killer (nk) compartments are essential for first - line, innate immune response... |
At the present time, synthetic meshes are frequently used in pelvic organ prolapse (pop) surgery with very good clinical outcomes . At the same time although rare, these complications can have serious consequences . During the past several years, many reports of complications associated with synthetic meshes have been ... |
Dermatologists have witnessed the many new successes in psoriasis treatment that are documented by improvement of the psoriasis area and severity index (pasi). It measures four aspects of disease activity, namely reduction of erythema, scaling and infiltration as well as area involved . All components of pasi can be do... |
Several clinical trials have investigated the effect of the long - acting anticholinergic bronchodilator, tiotropium bromide (barnes et al 1995), on lung function and dyspnea at rest (van noord et al 2000; vincken et al 2002; casaburi et al 2002; celli et al 2003; brusasco et al 2003; verkindre et al 2006) and during e... |
The mechanism of transmission of the agent or agents causing sars is not yet fully understood but is probably mainly by droplet secretions, fomites, or person - to - person contact, as much of the transmission in hong kong has been limited to healthcare workers and family members . To date, no evidence of airborne tran... |
Pheochromocytoma is rare but a critical tumor of chromaffin cells, which is frequently considered in the evaluation of hypertension, arrhythmia, or panic disorder and in the follow - up of patients with particular genetic diseases (1, 2). Pheochromocytoma is a one of the potentially fatal causes of childhood hypertensi... |
With the increasing availability of completely sequenced genomes, comparative genomic approaches are becoming more important to decipher the functions of genes . Methods, which are powerful, using the conservation of gene proximity on genomes (i.e. Determining potential operons) can understand functional associations b... |
Hemolysis, elevated liver enzymes, and low platelet count (hellp) syndrome is frequently associated with severe form of pre - eclampsia . However, the relationship between 2 symptoms is controversial, and the cause of hellp syndrome is still unknown . But there is a growing consensus that it has a familial tendency . A... |
Two major pathophysiologic abnormalities underlie most cases of type 2 diabetes (t2d): 1) insulin resistance and 2) defects in pancreatic -cell function . The current consensus is that both are essential components in disease pathogenesis even if their relative importance, the precise temporal sequence of events, and u... |
Meningiomas are the second most common central nervous system neoplasm in adults and account for 15 - 20% of all primary brain tumors . Although most meningiomas are benign, -10% of meningiomas demonstrate more aggressive clinical behavior, as non - benign meningiomas . The term " chordoid meningiomas " was first coine... |
Respiratory tract infections, such as community - acquired pneumonia (cap), acute exacerbation of chronic bronchitis (aecb), or acute bacterial sinusitis, are important causes of morbidity and mortality worldwide . The most frequent causative organism in cap is streptococcus pneumoniae or, less commonly, one of the aty... |
Crowns and fixed partial dentures (fpds) are the major prosthodontic treatment modalities for past several decades with factors like esthetics, contact points and pontics playing an important role in varying their design . However, one property of cement retained fixed restorations, retention, has been of prime importa... |
Pulmonary rehabilitation (pr) has become an integral component in the treatment of chronic obstructive pulmonary disease (copd) patients . The short - term effects on improving symptoms, exercise tolerance, and health - related quality of life (hrqol) were demonstrated by numerous randomized studies and meta - analyses... |
Rna has the dual capability of serving as a genetic polymer that mediates the inheritance of information and as a catalyst for chemical transformations and is therefore a promising candidate as an ancestral biopolymer . In early protocells, prior to the emergence of an rna replicase, nonenzymatic template - directed po... |
The development of an artificial endocrine pancreas (aep), composed of a system of continuous blood glucose monitoring and automated insulin infusion, has been a long sought - after solution in diabetic care . The intravascular approach to both glucose sensing and insulin delivery was abandoned in the late 80s, so curr... |
In recent years, the demand for herbal remedies in nigeria has been on the rise . Yet there are little or no scientific data to support medicinal claims of these herbal formulations . Herbals are usually sought after for their health benefits and these have become common medicines in many nigerian homes . It is recogni... |
Hallucinations, predominantly visual in nature, can occur in parkinson disease (pd) and are often related to the antiparkinsonian drugs . Visual hallucinations are a well - recognized problem . Besides visual hallucinations, patients with pd uncommonly experience different forms of hallucinations, such as auditory hall... |
Recently, the importance of quality of life research has been accepted . Regardless of the disease process, improving a person's quality of life has become an important goal of treatment programs . In the pediatric literature, quality of life studies have been largely confined to single disease states . Usually absent ... |
Cardiotoxicity and associated drug failures in clinical development or even withdrawals from the market contribute significantly to the rising cost of drug discovery and development in the pharmaceutical industry . It has been reported that 28% of drug withdrawals in the usa are associated with negative cardiovascular ... |
Blunt traumatic rupture of the diaphragm is a serious injury that is often difficult to diagnose . (1) it is an uncommon injury whose incidence is rising because of the increasing number of road traffic accidents in the last few years, together with better pre - hospital and hospital resuscitation of severely injured p... |
The jun activation - domain binding protein 1 (jab1) is initially identified as a coactivator of activator protein (ap-1) transcription factor and found a component of the cop9 signalosome (csn) complex, contained modulating signal transduction, gene transcription, and protein stability.12 jab1 interacted with p27 and ... |
The retinal pigment epithelium (rpe) performs highly specialized metabolic and transport functions essential for homeostasis of the neural retina (bok 1993). These include phagocytosis of photoreceptor - shed outer segments, transport of nutrients into and removal of waste products from photoreceptor cells and retinoid... |
H. pylori eradication is strongly recommended in all patients with atrophic gastritis and peptic ulcer disease, but may also benefit subgroups of patients with dyspepsia, and patients who start with nsaid therapy [16]. H. pylori eradication therapy is an important component of guidelines concerning these patients [7, 8... |
Kikuchi - fujimoto disease (kfd) is a rare, benign, self - limiting cervical lymphadenitis . The skin manifestations of our case mimicked systemic lupus erythematosus (sle), but immunofluorescence and serology were negative for it . A paucity of reports in literature with unusual skin manifestations has prompted us to ... |
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