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A 1-year - old, female spayed domestic shorthair cat with a 6 week history of upper respiratory signs and a progressive reluctance to move, which culminated in a right - sided hemiparesis, was found to have a sewing needle foreign body lodged in the brainstem . Surgical extraction of the needle was successful and the c... |
Stilgoe j, owen r, macnaghten p (2013) developing a framework for responsible innovation . Policy 42: 15681580 von schomberg r (2013) a vision of responsible innovation . In: responsible innovation: managing the responsible emergence of science and innovation in society, owen r, heintz m, bessant j (eds). Post (2015) r... |
A macular epiretinal membrane (erm) is a disorder of the vitreomacular interface characterized by fibrocellular proliferation on the anterior surface of the internal limiting membrane (ilm) of the macula.1 pars plana vitrectomy and membrane peeling is a standard surgical treatment for an erm and combined removal of the... |
In the united states, obesity is currently the second leading cause of preventable disease and death after smoking (19). According to the national health and nutrition examination study conducted in 20032004, 17% of u.s . Childhood and adolescence are believed to be critical periods for the development of obesity (6). ... |
Pityriasis rosea is a self - limited inflammatory condition of the skin that mostly affects young adults . A 6-year old girl with red - brown maculopapular eruption sized 0, 51 cm in diameter localized on neck, trunk and popliteal region visited our general pediatric outpatient clinic . After consulting dermatologist s... |
These irrigants should not affect the dentin surface or interfere with restorative materials [36]. The deleterious effects of certain irrigators, such as sodium hypochlorite, have been confirmed by previous studies, which have shown that bond strength is decreased [3,57]. Sodium hypochlorite is an alkaline solution wit... |
Spontaneous reporting of adverse drug reactions (adrs) by healthcare workers remains an important method of adrs detection . Such monitoring and reporting system contributes to signal detection of unsuspected and unusual adrs previously undetected during the initial evaluation of a drug . It encourages documentation of... |
M.tuberculosis could be isolated from intraoperativ biopsy; resistance testing revealed a completely sensitive strain . On july 2, treatment was started with rifampicin (rif) 600 mg / day, isoniazid (inh) 300 mg / day, pyrazinamid (pza) 1500 mg / day and ethambutol (etb) 1200 mg / day . After two month of combination t... |
A urethral diverticulum may be defined as a sac - like protrusion or pocket, which is continuous with the lumen of the urethra . Congenital diverticula are usually located on the ventral surface of the penile urethra, whereas acquired diverticula may be found anywhere along the urethra the peno - scrotal junction is th... |
The enhancement of aqueous solubility has remained a challenge for the successful development of new drug products in the pharmaceutical industry as the number of poorly water - soluble drugs is increasing . Many strategies have been employed to overcome this challenge by modifying the solid structure of the drug, and ... |
Every year up to 3 million us pregnant women are affected by gestational diabetes mellitus (gdm), diabetes mellitus during pregnancy, and it still has an increasing progress in pregnant women society . Gdm has unfavorable effects on both mother and the baby which could be categorized into short term and long term morbi... |
A new drug to market usually costs a lot of time for the research and the development and invests a huge amount of money . After decoding the human genome, the molecular biology and the proteomic fields make a remarkable advance; people understand more clearly the disease generation and the disease mechanism . Computer... |
S. paratyphi b dt+ with the resistance phenotype apcmsmspsutc had been isolated sporadically in various states of australia since 1997, and initial surveys showed a potential association with ownership of home aquariums (d. lightfoot, unpub . Data). In 2000, multidrug - resistant s. paratyphi b dt+ with an identical ph... |
Fiber - reinforced posts have superior advantages as compared with cast posts, generally regarding their esthetics, physical properties and their modulus of elasticity, which is similar to root dentin.1 posts are generally cemented with resin cements . Proper selection of resin cements influence the retention of posts ... |
Broad - necked aneurysms of the basilar artery (ba) apex are challenging to treat using both microsurgical clipping and endovascular techniques . However, the use of endovascular techniques for coil occlusion of these aneurysms has been dramatically favored over traditional open microsurgical procedures because of the ... |
Experimental methods and associated references are available in the online version for the paper at http://www.nature.com / naturebiotechnology/. |
Focal cemento - osseous dysplasia (fcod) is a fibro - osseous lesion that is a nonneoplastic reactive lesion . A case of 47-year - old female patient presenting with a diagnostic dilemma to the clinician is reported . Methods to achieve definitive diagnosis are discussed . Fcod can present with features of periapical p... |
Human motor performance does not always end up with the same behavioral consequences, but it rather fluctuates trial by trial even in a fully acquired and well - trained motor skill . This performance fluctuation seems to influence results of the competition in sports games and accidents in daily habitual activities (e... |
Although blood lead levels (bll) in us children have been dramatically reduced over the past 40 years, lead poisoning events continue to occur . The lead - based paint poisoning prevention act legislation was passed in 1971, and by 1978 the use of lead - based paint in residential housing was banned . The elimination o... |
Annually, 0.6 to 1 million people of 196 to 297 million malaria infected population lose their lives, mostly children under five and pregnant women (1). In eastern mediterranean regions, over 10 million clinical malaria cases occur each year, of which 50 thousand lead to death . Totally, 287 million which is about 60% ... |
In 1910, eugenics found an unlikely champion in russia: nikolai gamaleia (18591949), one of the country s leading bacteriologists . That year gamaleia founded a new professional journal, entitled hygiene and sanitation (gigiena i sanitariia), which became the first russian periodical to address various eugenic issues s... |
The differentiated thyroid carcinoma (dtc) is generally considered to be a neoplastic disease having a good prognosis with mortality rates around 5 - 15% . This is partly due to a spontaneous evolution often slow and to the ability of cancer cells to capture the iodine 131 (i). Nevertheless, dtc has a significant metas... |
Marijuana is the most commonly used illicit drug in the us, particularly among young adults, with marijuana use prevalence increasing in recent years . Chronic marijuana use is associated with cognitive impairment and addiction . While marijuana can be used in various forms (e.g., vaporized and edible), the most common... |
Post - traumatic stress disorder (ptsd) is a general anxiety disorder that was first introduced in 1980 in an american psychiatric association publication, diagnosis of mental disability and statistical manual1 . Ptsd occurs following an unexpected traumatic event or life - threatening physical and mental shock, and is... |
Noncommunicable diseases (ncds) and chronic illnesses affect all countries, including the gulf cooperation council (gcc) countries, of which the state of qatar is a member . The increase in prevalence of ncds is largely attributable to changing demographics and adoption of the lifestyle of developed countries, ie, poor... |
The management of metastatic renal cell carcinoma (mrcc) is in constant evolution and mrcc patients have an increasingly greater number of systemic treatment options . Currently, the biggest debate surrounds the selection criteria for first - line and second - line agents in patients with clear cell mrcc, and favorable... |
The nature of the new - born roles may cause a feeling of inefficiency and social isolation in the sufferer . In fact, after cancer is diagnosed, the patient will be hit by a crisis, his self - confidence will be at stake, his individual relationships will be disturbed due to uncertainty about future, the previous adap... |
In cancer care, research has often focused on nausea and vomiting problems, mainly on the frequency and management of these symptoms . Significant developments in anti - emetic therapy with the introduction of highly effective 5ht3 receptor antagonist have improved the control of emetic episode . Ironically, nausea and... |
Arterial tortuosity syndrome (ats) is a rare hereditary, autosomal recessive connective tissue disorder characterized by dysmorphic facial features, skin and joint laxity, tortuosity, elongation of the major arteries, vascular dilatation, stenosis, formation of aneurysm, pulmonary artery stenosis, and bowel hernia and ... |
Congenital pouch colon (cpc) is a rare regional variant of anorectal malformation comprising 2%9% of cases . The most commonly accepted narasimharao's classification divides this entity into four subtypes based on the length of normal colon proximal to the colonic pouch . Recently, saxena and mathur classified cpc - ba... |
Endometrial cancer is the most common gynecologic malignancy and is largely diagnosed in early stages [1, 2]. The primary means of treating localized disease is total abdominal hysterectomy and bilateral salpingo - oophorectomy . For all but low - risk tumors, adjuvant radiotherapy (rt) is thought to reduce chances of ... |
Antithrombin iii is a plasma protein that inhibits several of the serine proteases involved in the coagulation cascade, including thrombin and factor xa . A homozygous deficiency causes lethal thrombosis in utero or in the neonatal period; however, the heterozygous state occurs in 0.16% of the healthy population1 and i... |
For the past quarter century, worldwide usage of bariatric surgery has largely been governed by a 1991 set of recommendations from the national institutes of health (nih) that limit these operations to severely obese individuals (bmi 40 kg / m) or to patients with a bmi 35 kg / m and serious obesity - related comorbidi... |
Stress urinary incontinence (sui) is defined as a disease entity that presents with involuntary urine leakage during effort, exertion, or coughing . Sui generates severe social, economic, and psychological problems that can have a significantly negative impact on women's health . To treat sui, several forms of retropub... |
We analyzed data from the national tuberculosis surveillance system (ntss) at the centers for disease control and prevention (atlanta, ga, usa) and restricted analysis to cases reported during 20062013 to permit sufficient time for follow - up reporting of outcome data . M. tuberculosis complex isolates were identified... |
This is a case of 18-year - old african american female presenting with profuse per vaginal bleeding three days following an induced second trimester curettage abortion . She was diagnosed to be a case of disseminated intravascular coagulation disorder due to retained products of conception . This 18-year - old (gravid... |
Children younger than 18 years old who presented with a first acquired demyelinating event were identified by the dutch study group for pediatric ms, which includes 13 major pediatric neurology centers in the netherlands, as described earlier . Children were diagnosed with ms if they had a second demyelinating attack o... |
Antiphospholipid antibody syndrome (aps) is characterized by arterial and/or venous thromboses, recurrent abortions or foetal loss, and circulating antiphospholipid antibodies (apl) [1, 2]. According to the classification criteria, diagnosis of aps requires the combination of at least one clinical and one laboratory cr... |
Advanced age - related macular degeneration (amd) (mim 603075) is a leading cause of visual impairment and blindness in people older than 60 years . Amd is a common, late - onset disease that is modified by covariates including smoking and body mass index and has recurrence ratios for siblings of a case that are 36-fol... |
Classical exstrophy of the bladder is a rare anomaly with an incidence of 1 in 30,000 - 50,000 live births . There are a few case reports of covered exstrophy with anorectal malformation and the complete duplication of bladder, urethra, and the mullerian structures . However, covered exstrophy associated with duplicati... |
In 1960, the dow corning corporation developed the first injectable liquid silicone that was sterile, pure, and of constant viscosity for medical application . It was marketed under the name of dermagen and its initial purpose was for waterproofing the skin of burn patients . Previously, liquid silicone was available o... |
The institutional review board of seoul national university bundang hospital (b-1103/123 - 106) approved the design and protocol of this study . From march 2009 to february 2012, we prospectively recruited 41 consecutive patients who requested a hardware removal procedure after volar plating for drfs for reasons such a... |
Genus rhizobium consists of aerobic, gram - negative bacteria capable of forming nitrogen - fixing symbiosis with plants of the fabaceae family . Rhizobium leguminosarum species is subdivided into biovars that include strains isolated from the nodules of corresponding host plants (bv . Viciae from vicia spp . Viciae st... |
It has been confirmed that sensorimotor incongruence causes pathological pain such as phantom limb pain,1 and several studies with healthy participants have clearly indicated incongruence between proprioception associated with motor intention and visual feedback to be the cause of dysesthesias such as pain, peculiarity... |
Cardiovascular complications are major causes of morbidity and mortality following non - cardiac thoracic operations . In order to improve risk stratification and predictability of potential postoperative complications, various tools, such as revised cardiac risk index (rcri) or american college of cardiology / america... |
Uterine anomaly is a disorder which is identified during the work up for infertility, abortion and preterm delivery . It occurs in 4% of the general population and it constitutes 40% of the causes of abortions and preterm deliveries . These conditions are associated with spontaneous abortion (24%) in the first trimeste... |
Asthma is a chronic inflammatory disease of the airways that is characterized by variable airflow obstruction, increased airway responsiveness and inflammation, mucus overproduction, and airway remodeling . Asthma presents clinically as a result of combination of both genetic and environmental factors, and is the resul... |
Duplication of the thumb is the most common polydactyly of the hand . According to its anatomical location there is a gene responsible for pre - axial polydactyly types ii and iii as well as for complex polysyndactyly, which is located on chromosome 7q36 . Pre - axial polydactyly occurs sporadically with an incidence o... |
The ultimate goal of targeted nanotechnology - based drug delivery systems (nanoddss) in cancer therapy is to improve the therapeutic index of cytotoxic agents by selectively increasing their concentration at the tumor site . Liposomes in particular have attracted much attention as site - specific drug delivery vehicle... |
With the aging population there is a concomitant diversification of the united states such that, by 2050, it is predicted that the proportion of ethnic minority older adults (65) will nearly double (from 19.7% in 2012 to 39.1% in 2050). Thus, it is critical that cognitive screening tools be useful, applicable, and inte... |
A girl aged 13 years and 9 months with no previous morbidity was referred to our department with a 2-week history of evident periorbital and pretibial edema, myalgia, and fatigue . Her blood pressure was 130/80 mm hg, and urine dipstick testing showed proteinuria + + + and microhematuria + + . Laboratory investigations... |
It is often quoted that all drugs are dangerous and how dangerous a drug is depends on the skill of the prescriber . The skill includes the knowledge of uncommon adverse effects of drugs that may have huge therapeutic implications for the patient . Over the last few years, there have been increasing case reports of hyp... |
C57bl/6-cd3 (cd3) mice (23) were provided by d. kappes (fox chase cancer center, philadelphia, pa), and 129-cd3 (cd3) mice (16) were provided by d. wiest (fox chase cancer center). C57bl/6-v6/v1 tcr transgenic (tg) mice (line 134) (24) were provided by b.j . B6.129-cd3 (cd3) (25) and c57bl/6 (b6) mice were generated in... |
Describir el tratamiento quirrgico y los resultados en un grupo de pacientes con diagnstico de sndrome de adherencia grasa tras una ciruga de oblicuo inferior . Estudio retrospectivo de 6 casos diagnosticados y tratados de sndrome de adherencia grasa tras una ciruga de oblicuo inferior . La edad media fue de 24,67 aos ... |
Most surgical educators today understand that basic laparoscopic skills need to be taught outside of the operating room initially and that novel techniques in surgical education are necessary . Laparoscopic surgery requires a different set of skills compared with skills needed for open surgery . These sets of skills ar... |
Situs inversus is an autosomal recessive condition involving mirror image transposition of abdominal and thoracic organs and an incidence of 1/10,000 to 1/20,000 . When the heart is also transposed towards the right, it is called situs inversus totalis . Situs inversus partialis is a much rarer condition where the hear... |
A master metal die was used to make a specimen which has a highly polished surface approximately 15 mm in diameter, on which were inscribed two parallel lines for the determination of dimensional stability . A space of 5 mm was provided between the test die and the collar for the elastomeric impression material . Prior... |
Correction of class ii malocclusions includes growth modification, dental camouflage, and orthognathic surgery . However, dental camouflage with upper first premolar extraction carries the risk of over - retraction of the maxillary incisors and may result in an obtuse nasolabial angle and compromised soft tissue profil... |
Experimental dogs: ten healthy beagle dogs (4 males and 6 females, 16 years old and 9.414.7 kg) were used . All dogs were kept in our experimental animal room, and fed commercially - available dry dog food twice a day and given water ad libitum . All dogs were received clinical examinations for confirmation of healthy ... |
Aliquots of ethylenediamine tetraacetic acid - anticoagulated peripheral venous blood were collected from 37 hcv - infected patients being treated at the department of internal medicine, gastroenterology division, botucatu medical school (fmb), so paulo state university (unesp), botucatu, so paulo, brazil, in 2010 . Th... |
In the descent of man, darwin (1872) wrote that in contrast to other social animals such as bees or ants, mans motive to give aid no longer consists solely of a blind instinctive impulse, but is largely influenced by the praise and blame of his fellow men. Why should we attach weight to purely symbolic incentives such ... |
The mirror foot is a rare congenital anomaly associated with duplication of the structures of the foot . Type three is associated with a dysplastic tibia of which only 5 have been reported . Surgical management has been reported in only two of these five cases which are in the form of amputation . We would like to pres... |
Breast cancer is the most frequently diagnosed cancer and the leading global cause of cancer death among women, accounting for 23% of cancer diagnoses and 14% of cancer deaths each year, worldwide . Although breast cancer has a higher incidence in developed countries, half of new breast cancer diagnoses and an estimate... |
Dengue, a mosquito - borne viral disease, is emerging as one of the world's most rapidly spreading and important infectious diseases of the twenty first century a somewhat different disease scenario exists today, with all four viral serotypes circulating in asia, africa, and the americas, an estimated 3.6 billion peopl... |
These very modern curing devices offer several advantages, such as high power output and very low weight . Although the first - generation devices did not perform well,1,2 the latest generation is reported to work optimally.35 the lifetime of leds reaches 10,000 hours compared to approximately 50 hours for a quartz - t... |
Magnetic resonance imaging (mri) of the spine is commonly utilized in establishing a diagnosis of the pediatric patient with neck and back complaints . It offers excellent visualization of the vertebral body, ligaments, disk, and neural elements and is a valuable tool in the assessment of the pediatric patient with a n... |
Non - hodgkin's lymphomas (nhl) primarily involving the orbit, is relatively uncommon . We report a case of orbital lymphoma in a 62-year - old male with rare histopathological findings secondary to transformation of once cell type into another . Tissue diagnosis and molecular studies led to revelation of diffuse large... |
An 18-year - old white female with a history of type 1 diabetes since age 6 years presented with a 3-year history of poorly controlled diabetes, increasing insulin requirements (up to 3 units kg day) and frequent hospitalizations for diabetic ketoacidosis . The patient's diabetes had been under excellent control (a1c 6... |
With technical advancements in magnetic resonance imaging (mri), the reported incidence of spinal subdural hematoma (sdh) has been steadily increasing39). Furthermore, simultaneous spinal and intracranial sdhs are extremely rare, having been reported in only about 35 cases to date6). The patient is a 57-year - old man,... |
Mes - p(tms)2 (2) (408 mg, 1.37 mmol) is added to a cooled (70 c) suspension of 2,6-bis(chlorocarbonyl)pyridine (144 mg, 0.71 mmol) in toluene (20 ml). All volatiles are removed in vacuum and the residue is extracted with pentane and filtered over celite . Upon concentration to ca . 5 ml the zz - isomer of bisphosphaal... |
Microbial rhodopsins function as light - driven (retinal - based) membranal ion pumps, cation channels or light sensors (heberle and deupi, 2014). These rhodopsins are found in various microorganisms (archaea, bacteria, eukarya) (grote and o'malley, 2011; bj et al ., 2013; ernst et al ., 2014) and viruses (yutin and ko... |
B - cell acute lymphoblastic leukemia (pb - all) is a cancer of precursor b cells, involving the bone marrow (bm) and peripheral blood and is the most common childhood cancer . B - cell lymphoblastic lymphoma (pb - lbl) represents a rare form of this disease in which the lymphoblasts are confined to mass lesions with l... |
Despite our increasing ability to support vital organs and resuscitate patients, acute kidney injury (aki) is a frequent complication of cardiac surgery and increases morbidity and mortality . The primary resuscitation strategy for these patients is to restore effective renal blood flow (rbf) by fluid resuscitation to ... |
Alzheimer's disease (ad) is one of the leading causes of dementia today and it poses an immense societal challenge as the prevalence is expected to continue to rise . This makes it imperative to identify early preclinical changes in ad with high accuracy, in order for intervention strategies to yield effective outcome ... |
The recognition of anions in water remains a key challenge for the field of anion supramolecular chemistry.1 whilst examples of abiotic hosts capable of anion binding in organic solvents are plentiful, receptors that can operate in water without relying primarily on electrostatics or metal coordination are relatively r... |
Mechanical preparation of the root canal system is recognized as being one of the most important stages in root canal therapy . This process serves to optimize the shape of the canal for disinfection and obturation, giving it a uniformly tapered funnel shape, with a diameter that increases smoothly from the apex toward... |
It is often caused by blunt trauma, haematologic malignancy, coagulopathy and percutaneous or endoscopic procedure . We present a case of intramural duodenal haematoma caused by inferior vena caval (ivc) filter strut perforation managed by laparotomy and endovascular filter retrieval . This cause of duodenal haematoma ... |
Many animals spend their entire or some of their life cycle attached to other organisms or substrates . This life strategy is common in ectoparasites, epizoic species, sedentary benthic organisms, and inhabitants of wave - swept shores . A wide variety of attachment mechanisms are found in invertebrates such as monogen... |
Usually, nocardiosis is a rare infectious disease due to nocardia infections, but there are an increasing number of reports on nocardiosis . It is commonly seen in persons with a compromised immune system ., we present a rare case of cutaneous nocardiosis with involvement of the trachea, anterior mediastinum and sternu... |
Worldwide, esophageal cancer is the sixth leading cause of death from cancer . While the incidence of adenocarcinoma is increasing, the incidence of squamous cell carcinoma (scc) is stable.1 the cornerstone of curative treatment has been surgery . However, for a variety of reasons, the majority of patients with esophag... |
Unique physical chemical properties and microstructure features make sn ag cu (sac) alloys the worldwide most used lead - free solders . In particular, the sn - based sn-3.8ag-0.7cu (wt%) alloy (sac387), which corresponds to sn-4.1ag-1.3cu (at . However, two main problems caused by using such type of lead - free solder... |
A 33-year - old woman with a five - year history of essential thrombocythemia, was admitted to our hospital after the recent detection of a palpable mass in the left flank . Laboratory findings at the time of admission included a hemoglobin level of 14.7 g / dl, a platelet count of 7310/l, and leukocyte count of 24,010... |
Sulfasalazine used in the therapy of inflammatory bowel diseases, such as ulcerative colitis and crohn's disease [1, 2]. Ingested sulfasalazine passes to the colon without being absorbed in intestine and is split into 5-aminosalicylic acid (5-asa) and sulfapyridine by colonic bacteria [1, 2]. Most of 5-asa is metaboliz... |
After myxomas and lipomas, cardiac papillary fibroelastomas (cpf) are the most common benign primary tumors of the heart (7.9%).1) pathologically, these tumors grossly appear like a " sea anemone ", because they consist of multiple frond - like projections . Histologically, they are avascular tumors derived from normal... |
The development of efficient methods for the generation of medium- and large - sized heterocycles is an important facet of screening campaigns for facilitating drug discovery . In particular, medium and macrocyclic lactams constitute an important class of molecules in compound collections derived from target - oriented... |
The two efficacy studies described in this paper were conducted to evaluate the speed of relief onset from a new aspirin swallowable tablet formulation compared to regular aspirin . Based on the improved dissolution and pharmacokinetic profile, the expectation was that this formulation would have a clinically meaningfu... |
Histologically benign ameloblastoma accounts for 1% to 3% of tumors and cysts of the jaw123 . Ameloblastic carcinoma (ac), on the other hand, is even rarer; until 2011, fewer than 70 cases had been reported in the english literature4 . Malignancy in ameloblastoma has been the subject of controversy for a number of year... |
The study was conducted in the critical care unit of the division of cardiology, medical university of vienna (muv), and was approved by the ethics committee of the muv and the vienna general hospital (accession no . Each of the participants gave written informed consent . Between october 2007 and december 2008, consec... |
Pyometra is one of the most common diseases affecting intact bitches and is usually seen in middle or older age dogs (1). It can be a life - threatening condition since chronic and extreme inflammation is known to be associated with a sepsis - like disorder termed systemic inflammatory response syndrome (2). A combinat... |
Outside endemic regions, malaria may occur in travellers that have recently been to or visited endemic regions or in individuals from endemic countries recently arrived at or visiting nonendemic regions . An infection that was acquired in an endemic area by an individual (either a tourist or indigenous native) but diag... |
An ability to select relevant auditory stimuli from our surroundings is an important aspect of human behavior . One commonly used experimental scheme for studying neural correlates of auditory processing is the odd - ball paradigm in which a target acoustic stimulus (the deviant) is presented among frequent stimuli (th... |
Experimental conditions including chemical and instrumental effect dependently and/or independently on the efficiency of analytical methods in different levels . Therefore, the optimization of these conditions potentially develops analytical methods . Despite its limitation, the univariate method has still been applied... |
The goal of endodontic therapy is to eliminate micro - organisms from the infected root canal system . Mechanical cleaning and shaping of the root canal greatly reduces the microbial load, but because of the complex anatomy, organic, and inorganic residues including bacteria cannot be completely removed from the canal ... |
We report on three related congolese popliteal pterygium syndrome (pps) patients concordant only for the skinfold over the toenail . Mutation analysis revealed that the three affected individuals carried a heterozygous missense mutation in the exon 4, nm_006147.2:c.250c> t; p.arg84cys . The popliteal pterygium syndrome... |
Our research has had a focus on nicotinic acetylcholine receptors (nachrs) of parasitic nematodes because they are target sites that bind a major class of anthelmintic drugs . Nachrs are pentameric ligand - gated ion channels involved in synaptic transmission in the nervous systems of both vertebrates and invertebrates... |
A 57-year - old woman presented to our primary care clinic with tender, subcutaneous nodules on her right ankle and right thigh of 2 months duration . The lesions had begun as 12 mm reddish papules that progressed into 23 cm nodules . She denied insect bites, local trauma, or the use of new cosmetic products . The prev... |
Amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease characterized by the loss of both upper and lower motor neurons (mns) [13]. Als research has primarily focused on mechanisms regarding mn cell death; however, degenerative processes in the skeletal muscle, particularly involving neuromuscular junc... |
Psychiatric symptoms during pregnancy induce an increase in morbidity and also in the mortality levels among women and children . Fetal mortality suffers an increase among mothers with mental disorders: stillbirths occur 1.1 times more in pregnant women with schizophrenia and twice more in those who present affective d... |
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