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We will do our best to accommodate your busy schedule. Request an appointment today!
Whether you need a quick weekend trip, or a two week cruise, your dog or cat is more than welcome to stay at our boarding facility. We offer a climate controlled environment as well as separate ‘living quarters’ for each of your pets. We do not allow interaction with other boarders for safety purposes. We also have an outdoor, enclosed area where we let your dog out twice daily to stretch out his or her legs and romp around. For dog and cat boarding, we require all vaccinations to be current.
If dropping off for boarding, please allow yourself a little time to answer questions and fill out our boarding forms. If your pet needs to be boarded with medications, there is an additional charge to administer medications. A form specifically for the medications needs to be filled out and all medications need to be brought in their original bottles. If your dog or cat is on special foods, please bring the food with you. We do feed Purina wet and dry but we always prefer the pets to be on their own food so that they do not develop stomach issues due to switching of foods. We provide blankets, beds and towels so you do not have to bring those with you.
Your pet will look better than ever after a bath at our animal hospital. For a more lustrous look to your furry friend, we provide conditioning baths. Whether you are dropping off for the day for a bath or want a bath to be done the day you pick up from boarding, your pet will smell wonderful and be soft as silk! As we are not a grooming service, specialty haircuts are not something we can do here. But if you want to have a summer cut for your dog or a lion cut for your cat, that we can do!!
Schedule an appointment with our animal hospital for any of our pet care services.
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https://www.animalhousedoctor.com/adoptions-and-pet-care.html
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One year since I cut up my credit cards, closed my Bank Accounts and change the way I look at out our monetary system. Today, is somewhat the unofficial date in which I undertook that great step into a world unknown and feared by almost every person in the Western world. We are adapted to the world of Banking and the concept of capital. We now place value on everything with the common currency and regulate ourselves in such away that we must profit or gain in the sum of this capital. To step away from that, for most, this would be unthinkable. We would question this move as we can only function with the use of these financial institutions. I say, bull-pucky! Read on….
I never could understand how I could own something, and yet, never truly own its value and worth. I could never understand why I would need to pay for my labour credit (money) and use it to purchase material goods based on it’s value and vice versa and not the value that I put into it. Why does every transaction carry a fee… why not just give me my cash: no fees, no specail interest or no holds? Why I would need to go to a separate company or corporation to obtain my money for a small fee? This perplexed my in so many ways.
As of this day one year ago, I decided to put my money where my mouth was and make that great plunge and practised what I preached. So far the results have being mixed. The arrangement I have made have come under fire for the Bank that my employer uses for financial services. It has being a battle for them to give me cash from their Bank currency and exchanging it into cash. It is like going to the dentist and getting a tooth pulled. They get pissed, to put it mildly. I used the Bill of Exchange Act and the Bank Act in Canada to pressure them into giving me my cash. The threat of going to court is to heavy a price for them to deny me of my right under law. My employer cuts my a cheque, at great reluctance, and I cash it a their local cheque cashing outlet. No account necessary, and fees! I realize that this may not be the case for all.
However, with that minor set back, life goes onwards. With learning the value of cash, I have done many things that are now considered old fashion and out of date. With Banks pushing for everyone to move towards credit cards and electronic money, I still get moved to the head of line-ups when the ATMs(Automated tellers Machines) are down and point to point Banking machine are slow or cards are damaged.
In the end of the day, I feel more in touch with my financial lifestyle. I save in far more basic ways than what the Banks want you to do. I have cut off contact with credit companies and other financial outlets. And I watch very carefully as to what is going on in the news regarding new legislation and law in this money industry. I now have money to spend. I know how rediculious that sounds, but it is true. I have money to spend, not dredit and debt!
About a month ago now, I was sent in the post, a credit card application. I was appalled that after going to court over two years ago and winning, that they would even consider such a thing. I promptly sent the application form back with a copy of my personalized reply form. On it, it says that I morally believe that their service are wrong and that they are morally corrupting the Canadian people with their goods and that I support the criminalization of all credit institutions for their bad business and practises.
So, I hope to encourage all of you who read this to throw away your credit cards, pay off your debts and walk away from Banks. Buy only with what you can afford. Live by this simply logic: “If you don’t have the money for it, then you cant afford it.” Such a simple yet powerful statement. You can do it. You don’t need credit to live your life. Be free, stay free and spend free–pay yourself first!
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http://www.thomasso.com/2005/02/11/one-year-without-credit-nice/
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A direct flight to #Denver was my latest get-away. I’ve spent time in the Mile High City before at conferences. As a matter of fact, the first time I learned about the opportunity that took me to the Middle East was at a conference in Denver. And I had an amazing time with friends from college skiing one weekend a few years ago. So, even though it was cold and I flew into snow, I was ready to hang out in Denver.
I stayed at the Hotel Monaco Denver – @Kimpton Hotel. It was just as wonderful as I remembered it being. The family atmosphere, the great customer service, complimentary #winehour plus complimentary chair massages during wine hour – it was spectacular. I hung out at the bar the first night receiving an education on the fine art of making cocktails. Chad, the mixologist on duty, took excellent care of me and poured up a couple of cocktails that certainly hit the spot.
I walked down to the 16th Street Mall and did a little window shopping but found myself in Jazz @ Jack’s. Apparently this is the local place for jazz. Now, since I’ve come to know some of the finest jazz musicians in the US, I was quite disappointed in the talent. There was a local band playing the early set and it was just all weird. There was no jazz and sometimes, you just don’t need to do a different arrangement for some songs. I’ve never heard a more horrendous rendition of Michael Jackson’s Billy Jean. It was painful! The food, subpar. The venue, I loved. But hey, it was something to do!
Comedy Works Comedy Club was a cool venue too. The main act was terrible but the opening act was quite funny. I love the cave-like feel of comedy clubs. It’s a little cozy. I liked the drinks too but they made me put my cell phone in a pouch that I couldn’t open inside the venue. Weird but it cut down on distractions. @comedyworks
Of course I had good food in Denver. Panzano’s at the hotel was pretty good. While the dinner wasn’t as great as I remember, the breakfast was phenomenal. I had zucchini bread french toast. Yes, it was AMAZING! It was moist with a slightly crisp outside topped with fruit and I added whipped cream…cuz I love whipped cream! I went to Appaloosa Grill for a quick bite and ended up having one of the best glasses of wine I’ve ever had. It was a Malbec from Mendoza, Argentina – Reunion 2014. I can also appreciate when a nice red wine is served in a proper glass. I did have a bowl of bison chilli. It was great too. Then I found a cute little breakfast and brunch place: The Egg Shell. Trendy little place with exposed ceilings, concrete floors, great food and a full bar. The service was great too.
The highlight of my trip was walking through the snow filled park on my way to the Denver Art Museum and coming upon a group of people feeding the homeless and providing warm clothes. I was so moved. The group: Impact Locally, is out weekly providing services. They alternate services: food, clothes, blankets, etc. They even take some of the homeless children hiking during the summers and tubing during the winters. They mentor too. To see people in action just really spoke to my heart. I’m always looking for an organization to support. @ImpactLocally received my support that day and I will continue to support them. I’m glad I stumbled upon such warmth and compassion.
Update on my discomfort in 2017:
Even though I tried to back out at the last minute, I went through with my first experience of getting uncomfortable. I spoke before a group of people at my organization for #MLK day. I was so incredibly anxious that I was not in a good place. However, I’m glad I went through with it. I told a story of how I rallied friends in 5th grade to hang banners and posters about MLK at a predominantly white school that I was bussed to. Oklahoma was one of the states that didn’t recognize the federal holiday as MLK day and I couldn’t quite understand that (FYI, it wasn’t until 2000 that all US states actually called MLK day, MLK day). Of course I was called into the principle’s office for causing a stir but I couldn’t understand why they didn’t call it MLK day. Well, the next school year, the district calendar had it marked as MLK day. I like to think that maybe I had something to do with that but who knows. The point of my story was that in today’s times, MLK’s dream has not yet come to pass. I recognize that I must rekindle that fire I had as a young child in order to move forward and continue the work. I invited those I spoke to to rise up and find their fire so we can make change together. So…first test of discomfort…I think I passed.
Living life…and it’s so good.
Looking for a book to read Click here…
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https://kendradawnrn.com/2017/01/21/snowy-denver/
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I haven't seen any publicity for this, but the annual Beaux Arts Festival will be held on campus this weekend. It's always fun, and they have some very fine exhibitors. It's somewhere between your basic street fair and some giant or overpriced event where you can't afford anything on show. There are some very expensive pieces (both nice and “huh”-inducing) and also some reasonable ones.
Over the years I've bought quite a lot of jewelery (for spousal birthdays), and a few pieces of art now hanging on our walls.
When: 10 a.m. to 5 p.m. Jan 9-10, 2010
Where: Grounds of the Lowe Art Museum, 1301 Stanford Dr., on the University of Miami Campus
I hope it warms up a bit by the weekend.
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https://www.discourse.net/2010/01/beaux_arts_this_weekend/
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Finish: Fully Pre Finished
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The Valencia Fully Pre Finished Walnut Glazed Brilliant Clear Cut Frosted Bevelled Internal Door is an excellent addition to LPD's Internal Walnut Collection.
All Of LPD's Walnut doors are pre finished and are 35mm thick, except for metric, which are 40mm. Half-hour fire check doors are 44mm thick.
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https://www.formbydoors.com/products/valencia-pre-finished-walnut
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Book review: 21 Lessons for the 21st Century, by Yuval Harari.
Yuval Harari joins Steven Pinker and Jordan Peterson in proposing lessons to grapple with the challenges of this century. Based on the success of his past two books many are awaiting Harari to tell us how to avoid past mistakes and navigate our future.
Harari writes with flamboyance and vivid turns of phrase and offers many interesting observations and smart details. His clever writing almost obscures the logical shortcomings of his arguments. Behind his style of cool logic and balanced evaluations Harari’s message is an incoherent polemic that verges on the nihilistic and bizarre. Sadly, not a single one of Harari’s 21 lessons stands up to serious scrutiny.
Harari’s first logical shortcoming is an old fallacy: extrapolating future problems from the present. Harari’s take on the future reminds me of one of my first classes in business school. The professor cautioned us that had we listened to the predictions of 19th-century American business prognosticators – who extrapolated from the problems they faced – we would fear the rapid buildup of horse manure as the biggest obstacle to further urban growth.
In a similar vein, Harari assumes that we will remain on auto-pilot and that increasing convergence of big data, artificial intelligence (AI), social psychology algorithms, and large networks will lead to unprecedented elite dominance, manipulation of our feelings (and elections) and mass unemployment. The problem with this argument is that historically unanticipated developments have usually disrupted auto-pilot outcomes.
The advent of computers also saw the creation of hackers. The discovery of antibiotics was accompanied by the identification of viruses and then of bacteria that became antibiotic resistant. New technologies also led to new jobs. Whoever heard of a social media manager in 1980? Harari himself naturally claims that he does not wish to see the elites oppress everyone (page 80). But he seems to think that this time we won’t have much choice.
Harari’s second logical shortcoming is another cliché of doomsayers: his insistence that our presumed future problems are radically different from anything we have ever faced. Harari argues that AI, cyborgs, bio-engineering (and elite control thereof), climate change, and nuclear war are game changers – and these are indeed profound challenges.
Yet, there is another case to be made: new technologies and elite control, environmental damage, and war are as old as humanity itself. Ancient Egyptian and Mesopotamia elites jealously guarded expertise like writing and astronomy as priestly knowledge. Modern industrialists tried to monopolize machine technologies from competitors and workers by force. Pre-industrial societies such as Easter Island (among others) authored their own ecological collapse. And ancient warriors like the Mongols killed 40 million people – one of the deadliest episodes in history.
But the elites across human history were never able to stay in control. People sold or stole the patents. They also fought to create societies that applied values and laws that stopped such concentration. Humans have also learned from technical mistakes – DDT and CFCs once ubiquitous are now illegal. Harari himself sees regulation – as the means to keeping elites in check. Yet he strangely implies that these solutions have nothing to do with past lessons.
Harari’s’ third logical shortcoming is that nothing of past human civilization is relevant to our future. Harari insists that everything from nationalism, liberalism, to all religions – except perhaps Buddhism – are useless in addressing our current predicaments. His logic could not be more circular: all contemporary problems are in his view either technical problems, policy problems, or identity problems (page 128). Since Harari claims that because neither religions nor past ideologies have anything to say about technical problems or policies and only worsen identity frictions they are irrelevant. While Harari just states his opinion as fact, many historians view the laws and values of major religious traditions and modern ideologies like liberalism as the very forces that led to progress against elite domination, war and destruction.
Take the Bible: it rejects elite power by applying the law to everyone and by forbidding property monopolies via the jubilee years. Other Mesopotamian laws which unlike Biblical laws they were based entirely on the status of the victim and the perpetrator – a distinction Harari fails to make (page 189). No wonder, as even Foucault admits, the Bible was the major source of truth to power since the Middle Ages.
In what is possibly his most bizarre chapter, Harari argues we need a new definition of justice because the command not to steal does not apply “when the global system is ceaselessly stealing on my behalf without my knowledge” (page 228). I fail to understand his logic. Why not advocate for carbon taxation, investment in clean technologies, and the application of criminal, environmental, and labor laws in all countries? Instead the solutions Harari offers are entirely rhetorical.
Harari’s fourth logical shortcoming is his insistence that all of human civilization consists of stories of equal fictitiousness. The logical problem with Harari’s use of the word stories/fictions started in his book Sapiens, in which he refers to money, corporations, to nations, religions as fictions. Yet fiction is usually defined as “a pretense that does not represent actuality but has been invented.”
It is hard to get on Harari’s train of thought and include everything on his list as fictions. Money, for example, is a representation of a bill of payment – and therefore a contract. Liberalism is a set of values, laws, and relationships. Neither are fictions like mermaids or Harry Potter. Moreover many of the ideas Harari calls stories are derived from practices in reality. Money seems to have originated from barter of useable goods evolving to the exchange of goods for something of enduring value (precious metals, salt), to bills of payment in lieu of coins.
Where Harari sees fiction; I see the development of a more sophisticated tool. As to liberalism – the story which in Harari’s words “cherishes human liberty as the number one value” and leads to humans wanting to have a say in politics and in their own lives (page 44) – it too seems to be pretty ingrained. Exerting one’s will and independence is something we see in two-year-old children. Liberalism simply ensures the natural desire for liberty through a social contract. Nothing is gained from calling so many things stories other than a rhetorical sleight of hand. And what is lost is the crucial difference between rational descriptions of the world and of human relationships with stories used for political ends.
I worry that if everything is a story unmoored from reality and experience, many will again feel free to create real fictions – like racial superiority, godly birth, or an elite class – as the sign that they deserve to oppress and dominate others. It is these dangerous fictions that the major religious traditions and ideologies Harari so despises opposed with their universal application of the Golden Rule.
Harari’s wonderful writing style obscures the incoherence, polemical nature, and nihilism of his message. Harari writes with wit and offers many interesting examples. We are given keen observations about the history of war – Kamikazes were the first guided missiles. But under the veneer of a mature message of humility and skepticism is a huge amount of waffling and incoherence.
We are told religion has been totally nefarious (pages 126-139) but then also inspires compassion (page 201). Post-truth is a feature of all of humanity (page 236), but then commitment to truth is a defining feature of secularists (page 212). Despite the semblance of analytic distance and fairness, Harari’s’ book has the features of a polemic – mainly directed against religion, though culture gets hit as well. For example, Harari defines secularism as everything that is good: truth, responsibility, compassion. As to whether Stalin was secular Harari writes: “Whether one should view Stalin as a secular leader is therefore a matter of how we define secularism.” (page 212)
When you stack the deck, you usually win and Harari does a lot of deck-stacking. He also makes outrageous generalizations like “ to the best of our scientific knowledge none of the thousands of stories that different cultures, religions, and tribes, have invented throughout the ages is true” (page 283) or “European civilization is anything Europeans make of it […] (page 96). And gives reductionist accounts like people believe this nonsense because it gives them identity and makes them feel a certain way (page 284). Harari’s existential nihilism – especially in its Buddhist form – would be worthy of debate, if he did not couch it in such grandiose assertions. Assert it and they will come seems to be his motto.
For all people concerned with where we are going in the 21st Century, I believe we should take another look at time-honored morality and texts. Harari’s chapter headings are perhaps the most valuable part of the book. Yes, we need to talk about equality, post-truth, meaning, justice, work, belief, fiction and reality. But with his simultaneously incoherent, polemical, and manipulative claims, Harari also does not deliver. For thoughtful readers, I would suggest going back to the very traditional texts that Harari dismisses. The Bible’s 10 big lessons are a good place to start.
Scott A. Shay is the author of In Good Faith (Post Hill Press, September 2018) and is the Chairman and co-founder of Signature Bank of New York.
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https://asiatimes.com/2019/01/lessons-that-simply-dont-hold-water/
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Looking for timber fencing for your home or business in the local area? Here's five reasons to choose fencing made in Somerset.
1. Made in Somerset for over 35 years
Consistent high quality is difficult to find these days, but you can rest assured that our timber fencing is made to the highest standards. By manufacturing our fencing at our site in Somerset, we ensure that no corners are cut. We have been making fencing panels for over 35 years and pride and precision is a key ingredient.
2. Sustainable timber
Our fencing is made entirely from sustainably sourced timber from FSC managed forests. By buying directly from us you can be confident about the origins of the timber used in your fencing.
3. Supporting local craftsmen and businesses
You can't beat the feel-good factor of knowing that your fencing was made by local people who've honed their craft over many years. When you buy from Somerlap, you're also directly supporting the local area because we invest back into our community as often as possible.
4. Local delivery and installation
Another benefit of choosing timber fencing made in Somerset is that we can easily deliver and install for you. Somerlap have built strong ties with local and trusted contractors, so you can be sure that your project will be professionally installed by a trusted local contractor. If you'd like more details about our installation service, please contact the Somerlap team.
5. Five star reviews
Don't take our word for it, here are just a few of our five star reviews from some very satisfied customers:
"At last – high quality sturdy fence panels that don’t get blown down in winter! Recommended."
"We are well pleased with our new waney panels, posts and caps. The fencing has been erected and looks solid, smart and natural. We very much appreciated the help given by the Somerlap staff."
"Excellent panels, easy to install and well made. I also had two special length ones made to fill gaps and the service was excellent."
"We are very happy with our new waney panels. They are very well made and look lovely and solid. The staff are lovely and very helpful. Many thanks."
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https://somerlap.co.uk/blogs/blog/choose-fencing-made-in-somerset
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It’s been going around the Facebook like wildfire, and even the inoculated among us are not immune. So, here’s my humble contribution to the meme:
1. I don’t believe in randomness. The irony in selecting 25 “random” things about oneself is thicker than Karo syrup, which is my favorite.
2. I grew up about 10 miles from a NASCAR racetrack, but I’ve never been to a race. I once won a pair of tickets, but sold the set for $35, which at the time I thought was a king’s ransom.
3. My undergraduate major was Advertising, and I once shared a Calculus class with Peyton Manning. Who would have thought that he would have gone on to become such a great advertiser…
4. When I was in first grade, I got only one answer on a math test incorrect. I left this problem blank: 1-1=__. I was always told zero is nothing, so I left it blank.
5. I tend to keep my eyes open when I pray. This goes back to childhood, when I thought that the reason people closed their eyes when they prayed in church was because God descended from heaven and walked the aisles. I often tried to sneak a peek.
6. I have on occasion added “Pig Latin” to the repertoire of languages on my resume.
7. I’ve never been offered an interview from any of the aforementioned resumes. Arrow-nay inded-may were those prospective employers.
8. Every day, I get into cars with strangers to ride 25 miles to work (this is true!). So far I haven’t been abducted. If you’re reading this and I have been abducted, disregard the previous sentence and call the police already.
9. Quite the romantic, I proposed to my wife as we were sitting on a downed telephone pole. She didn’t see it coming.
10. Once in high school, some friends and I were chased by a sheriff in a Crown Vic., blue lights ablaze. We got away. I guess that means I’m still on the lam?
11. My favorite word is “seldom.” It’s fun to say, but I rarely use it.
12. My favorite weather phenomenon is fog. The reasons behind this are cloudy.
13. I try to always know more than I let on, but most of the time the converse is true.
14. Laden with a loaded internal frame backpack, I once tried to leap aboard a moving train while chasing it across an iced platform. I was roundly tackled by a member of the Belarusian militia who proceeded to question my sanity in no uncertain terms.
15. I’m married to a Kentucky Wildcat who some would say is my complete opposite. I like to say we’re complementary.
16. From Kindergarten through 12th grade, I only got in trouble at school one time. In first grade I had to sit out ten minutes in recess for talking. That’s it. No paddlings (they did that at school back then!), no themes, no suspension, nothing. Doesn’t mean I was always good. Just means I didn’t get caught.
17. A life-changing encounter with Jesus of Nazareth spoiled any dreams I had of becoming a world-class con artist (although I did want to be a lawyer for a little while…).
18. I’ve run a mile in under five minutes only one time.
19. My son is frighteningly smart, and watching him and my daughter grow leaves me in awe much of the time. My wife thinks that my daughter has me “wrapped.” She’s right, of course, but I can still pretend otherwise…
20. My favorite movies these days tend to be older ones. Hollywood has lost the art of storytelling in exchange for gimmickry.
21. My favorite novel is Dostoevsky’s The Brothers Karamazov. I read it ten years ago, and it took me six months to read. It still haunts me to this day, and I plan on re-reading it this year to see what effect a decade of pondering can have on the book.
22. I cannot sleep unless I am lying down. I’ve never slept in a moving automobile or on an airplane. On one long, multi-day international travel disaster, this unique characteristic caused me to stay awake for 54 hours until I had a place to lie down.
23. I mourn the passing of a good T-shirt, pair of underwear, or pair of jeans. My wife rejoices at the passing of such items (of mine), and I suspect she often contributes to their passing…
24. It took over a decade of playing, and countless games, but I finally beat my Dad at chess last year.
25. Mayonnaise is a condiment best left unserved.
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https://www.jaredbridges.net/category/life/page/2/
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The Money Pit (1986)
Looking at Tom Hanks’ output over the last twenty years or so, a new viewer to his work would be forgiven for thinking he was always middle of the road. It’s difficult to appreciate that he started his career playing in broad comedies like The Money Pit. In fact, he was one of Hollywood’s biggest comedy stars of the eighties. And he was damn good at it too.
Tom Hanks and Shelley Long play Walter and Anna, and Alexander Gudunov steals almost every scene he is in as Anna’s narcissistic ex-boyfriend. Walter and Anna buy a dream house cheaply to start their life together, but as it falls apart around them it soon becomes apparent why the house had such a low price.
The Money Pit was one of my mum’s favourite movies – certainly the comedy that I heard her laugh at the most. I must have seen it a dozen times when I was a kid – many times with my mum – and she laughed as hard the twelfth time as she did the first. She has the preternatural ability to extract almost the same value from every viewing: it’s like some kind of cinematic amnesia. I envy that, because with something as funny as The Money Pit it would be great to have that first experience back again.
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https://briangrantross.com/2017/11/27/monday-movie-mentions-28/
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Started as the first employee of Yahoo! Hong Kong office 15 years ago, Ivy Wong has since built top online presence for major media brands in Hong Kong, initially as Asia’s Senior Director of Global Sales at Yahoo!, then as COO of TVB.com, followed by CEO of Next Mobile.
Ivy has successfully expanded two traditional companies into digital. At Next Mobile and TVB, she has developed products such as the very popular TVB “myTV” Catchup TV series and Animated News（蘋果動新聞), each with millions of monthly unique visitors. Ivy is perhaps the only person who has swept the media industry across the print, digital, TV and mobile channels.
After leaving Next Media, she co-founded a lifestyle-oriented, Instagram-like mobile platform dubbed Viss (www.viss.me). It is one of the hottest startups in Hong Kong with a 6-figure seed investment raised and about 2.8 million monthly unique visitors.
Ivy is also the CEO of HMVideal, HMV’s new concept store in Hong Kong.
Since graduating from University of Toronto studying Economics and Marketing, Ivy has joined Yahoo! as the first member in Hong Kong. After 9 years, Ivy became the first local member to head its Global Sales office. Ivy was the leader in building global infrastructure, taking Asia-based multinationals (e.g. Cathay Pacific and Samsung) onto the global stage and bringing US/European based multinationals (e.g. Nokia and General Motors) to Asian markets.
In 2007, Ivy took on a new challenge and became the Chief Operating Officer of TVB.com. She developed the TVB digital media business, which included rebuilding tvb.com from simply an online programme guide to one of the biggest branded video portals, with the very popular “myTV” Catchup TV Series, increasing traffic from only 200,000 monthly users to 7.4 million unique viewers per month. Ivy also has successfully expanded TVB viewership to younger audiences and busy working adults, where 80% of their audience are below age 40, complimenting TVB’s original mature audience base. She was also responsible for the P&L and operation of TVB.com, where advertising revenue grew 250% from 2008 to 2010.
In 2011, Ivy was appointed Chief Executive Officer of Next Mobile Limited, whose parent company is Next Media Group (壹傳媒) that publishes 12 newspaper and magazines in Hong Kong and Taiwan, including Apple Daily and Next Magazine. With the vision of building a next media empire, Next Media has been investing in producing various digital content, like the very popular Animated News and videotainment content; and gaming and commerce. Mobile as Web 3.0 is the key focus of Next Media to build deeper engagement with our users through these digital content and various new initiatives. With the core responsibilities to oversee the company’s overall mobile strategy and grow the digital advertising business, Ivy has grown Next Media’s digital business by over 60% in Hong Kong and Taiwan. With her leadership, Next Media partners with major mobile manufacturers and operators to successfully expand into mobile world. Apple Daily is currently available on iOS, Android, Win 8, Samsung TV and soon on Blackberry platform. Traffic has growth over 50% in 12 months period. Next Mobile also enters into mobile gaming by launching two successful location-based role playing mobile game in Hong Kong, Taiwan and Japan. One of the game, “Life is Crime”, became the number 1 top grossing mobile game on iOS platform. Location-based mobile commerce is also under development.
Ivy is also an advisor to Happy Tree Social Services, a non-profit organization providing medical, educational and social services to the disadvantaged minority over the world.
All volunteer hours must be completed during September to December 2014.
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https://timeauction.org/auctions/27-meet-ivy-wong-former-ceo-at-next-mobile-ivy-wong
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14873211
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Laser Shapes - State
Celebrate your home, wedding location or favorite vacation spot with our laser cut states. They are easy to use as gift add-ons, or to embellish picture frames, crafts and mixed media projects. You really can't go wrong with these! Just choose a state and then, paint, stain, or embellish to create a timeless piece.
Dimensions: State sizes vary depending on shape. Average size is approximately 5" x 5". Hawaii will only include the main island.
Material: Made of 1/8" thick Baltic birch plywood
Hardware: Easy to display
Made in USA
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https://unfinishedwoodco.com/products/laser-cut-states
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14873212
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Current work in wildlife, rivers, public lands, and climate
Citizens Groups Denounce Oil and Gas Industry Harassment of Front Range Residents
In a motion filed in state court this week, Extraction Oil and Gas is demanding the Plaintiffs, conservation group WildEarth Guardians and Broomfield citizens’ group Residents Rights pay the company more than $15,000 in attorneys’ fees that were allegedly incurred when Extraction Oil and Gas moved to intervene in a case.
“This just underscores that Colorado’s oil and gas industry is at war with Coloradans and Colorado communities,” said Jeremy Nichols, Climate and Energy Program Director for WildEarth Guardians. “In classic oil and gas industry form, rather than take responsibility for its actions and respect communities, Extraction Oil and Gas is using the threat of attorneys’ fees to stifle activists and silence opposition.”
Last fall, WildEarth Guardians and Residents Rights sued the City and County of Broomfield over the way its City Manager administratively approved Extraction’s massive fracking plans in the community. Then City Manager, Charles Ozaki, approved Extraction’s development despite a citizen initiative that expressly prohibited approval unless the condition of protecting health and safety had been met and despite lacking authorization to do so under the terms of the Operator Agreement.
The suit was filed on behalf of members of WildEarth Guardians and Residents Rights who have been impacted by the alleged violation of their Charter and improper approval of Extraction’s Comprehensive Drilling Plan for at least 84 wells in close proximity to Broomfield neighborhoods.
“Broomfield officials turned their backs on protecting the health and safety of Broomfield residents to appease the oil and gas industry,” said Becky Early, Board Member of Residents Rights. “The result of this action is that our community is now being torn apart by drilling pads, pipelines, fracking operations, while complaints of adverse impacts have been filed with both the City and State.”
A Broomfield judge dismissed the case earlier in the month, holding residents couldn’t enforce their charter, specifically a provision passed by Broomfield citizen initiative to specifically protect Broomfield residents from adverse impacts of Oil and Gas development that so many Colorado communities have been forced to accept. The case never went to trial and the issues were never briefed. WildEarth Guardians and Residents Rights are now weighing an appeal.
“Here in the United States, we have the right to free speech and that means the right to question our government and to use our courts to resolve those questions,” said Kim McNaughton with Residents Rights. “Extraction’s motion seeking $15,000 is nothing short of an assault on these rights. It’s a vindictive attempt to use the threat of paying attorneys to silence citizens who speak out.”
In its motion, Extraction Oil and Gas claims that it had to pay its lawyers for nearly forty hours of work to draft a single motion to intervene, where they allege the legal issues were supposedly so indisputable that the Plaintiffs should be sanctioned for opposing them.
“There’s nothing frivolous about Americans exercising their rights,” said Nichols. “This is nothing short of an attempt to intimidate and bully residents who dare to oppose the oil and gas industry.”
“Broomfield Residents have sincere concerns about the impacts oil and gas development is having on residents living near large scale industrial fracking. These concerns prompted our community to amend our local Charter,” said Tom Yeager, Board Member of Residents Rights. “We took this issue to the courts because we did not believe that our Charter amendment was being upheld during the permit approval process. The courts are meant to resolve these kinds of disputes.”
Oil and gas companies in Colorado have frequently engaged in retaliatory litigation against citizen activists as an attempt to stifle advocacy. Last fall, a judge rejected a lawsuit filed by a western Colorado oil and gas company that targeted an activist in the town of Paonia. The judge dismissed the case because it was meant to “silence a critic.” Although Colorado recently passed a bill to prevent this type of legal harassment, “Strategic Lawsuits Against Public Participation,” it has not yet been signed by the Governor and will not become effective until July 1, 2019.
WildEarth Guardians and Residents rights will be opposing Extraction’s $15,000 demand and requesting the court dismiss it.
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https://wildearthguardians.org/press-releases/citizens-groups-denounce-oil-and-gas-industry-harassment-of-front-range-residents/
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Growth Trends for Related Jobs
Many employers require candidates to take an assessment test as part of the pre-employment screening or interview process. The assessment may evaluate whether a candidate has the specific knowledge, skills or abilities required for the role, or may give the employer information about the candidate’s personality or style. The assessment may take a variety of formats, including online survey, paper questionnaire or interview format over the phone.
Schedule the assessment test. Work with the potential employer to pick a time for the assessment. Try to pick a test time when you are well-rested, alert and clear minded.
Understand the purpose and directions of the assessment. Ask the assessment administrator to provide information about how the results of the assessment will be used as part of the decision-making process. Read or listen to the directions of the assessment. If there is anything you do not understand, clarify it before starting.
Take the assessment, following the directions provided. If the assessment is a skill-based assessment, try to answer the questions as accurately as possible. If the assessment asks questions about your personality and preferences, answer as honestly as you can. Try not to over-think your answers or tailor your responses to what you think the employer will want to hear.
Clarify next steps with the potential employer. Make sure you understand the next steps in the process and when you can expect to hear the results. Often, candidates who perform well on assessment tests will be invited for additional interviews.
Try to relax when you are taking the assessment. Most often, you have been invited to take the assessment because you have demonstrated qualifications for the role.
If you participate in a personality or style assessment, sometimes the employer will share the results with you and ask for your perspective. During this discussion, try to avoid being defensive. Be open to discussing your strengths and development opportunities. Even if you are not offered the position, the self-reflection can be valuable for your personal growth and ultimately help you in your job search.
Do not try to cheat or game an assessment test. This shows a lack of professional ethics and is the best way to ensure you are not offered the position.
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https://careertrend.com/how-5495453-correctly-assessment-test.html
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Let our family care for yours
UPDATE: Our office will be reopening on Monday, May 18th, 2020.
Click on the button below to view our updated safety procedures and our new screening form. Patients should expect to complete the form when coming in for an appointment.
Caring for your dental health
dentist in londonderry, NH
Welcome to Ebright & Smart Family Dentistry – your new dental home in Londonderry. At Ebright & Smart we strive to provide quality, comprehensive care for the entire family. It is our goal to treat every patient with compassion and respect in a comfortable environment. We hope to build long lasting personal relationships with all of our patients, helping them achieve and maintain their oral health.
We pride ourselves on treating every patient like family. We look forward to meeting you and welcoming you to our practice.
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https://www.londonderrydentist.com/
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14873215
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Selaa Ses Yachts veneitä myytävänä
|Selection of boats that may be of interest from the list of available boats for sale above.
3 298 775 EUR
2007 SES Yachts 111' - Custom Build "Sunrise" New to the Market! Launched in 2007 by Turkish yard Ses Yachts, she was built from an epoxy-laminated mahogany hull to RINA standards. Rece
470 000 EUR
24m motor yacht built in 2001 year (refit was done in 2011) at Ses Shipyard (Turkey). The boat is in good condition, equipped with 2 MAN 1200hp each ( 350 engine hours), 2 generators etc. Accommodatio
750 000 EUR
VIDEO - Watch the full walkthrough video on this page. DELUXIA Custom built motor yacht that was built in 2008 by SES SHIPYARD from Istanbul, second generation familiy shipyard which specializes in cu
1 890 000 EUR
Watch the full walkthrough VIDEO on this page. M/Y IGUAZU Is a 23.5 m composite hull custom-built motor yacht that was built by SES shipyard design team together with Duck Design from Italy
295 000 EUR
S/Y SERENITY Sold from her first owner, 19.2 m Sloop sail yacht built in Turkey in 1991 by SES shipyard to design by Horst Stichnoth. She is a great sail yacht with amazing wood interior craf
600 000 EUR
Boat Name Sudaki Dimensions Length: 17.64 m Beam: 5.2 m Max Draft: 0.85 m Accommodation Number of cabins: 3 Number of heads: 1 Number of twin berths: 1 Number of double berths:1 Number o
*Tämä hinta perustuu nykypäivän valuuttakurssiin.
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https://www.yachtworld.fi/veneet/kategoria/tyyppi/Ses+Yachts
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Recency effect means using recent experience and knowledge to determine future occurrences. People mostly remember the experience that has occurred recently or knowledge that has been generated recently. Recent knowledge and experience are, therefore, easily used to analyze future trends. Recency effect is applicable in business activities because it influences the shopping behavior of customers.
Connection between primacy and recency effect
The first and last information about a product or service is very important for marketers. The first information aims at illustrating the positive aspects of a product. Customers are attracted to products or services that have positive information; for example, water resistant smartphone or healthy food products.
Primacy effect illustrates that customers are attracted to information that is positive or useful. Recency effect also aims at ensuring that the last information that a customer has about a product is positive. Marketers use the primacy and recency effect to influence the customers to purchase more quantities of the goods or services that they offer.
Achieving recency effect
There is a huge demand for products and services that have recent positive information. Business professionals can ensure recent positive information is achieved through effective advertising, packaging, customer care, and after sales service. Companies should invest a lot in mass media and social media advertising. This is because billions of people globally have access to at least one type or mass or social media. Advertising shows the benefits of using the product. The packaging should be attractive. The staff should ensure that all the needs of the customers are achieved.
People are more likely to purchase a product if it has recent information. Customers are also likely to purchase a product or service that indicates a recent experience. Luxury shoppers place more orders for latest product designs. Customers prefer to purchase luxury items that are recent; for example, new car models or latest Rolex watch design.
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http://hypothesizes.com/1030/recency-effect-influences-shopping-behavior-customers/
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14873217
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Spawn of Possession is a Swedish technical death metal band from Kalmar. Formed in 1997, the group has a total of three studio albums, Cabinet published in 2002, Noctambulant in 2006, and Incurso in 2012.
In his debut in February 1997, Spawn of Possession consists of Jonas Bryssling (guitar), Jonas Karlsson (guitar) and Dennis Röndum (drums). The idea of the group was to create a brutal music that would push the limits of death metal. After three years of performing covers, the band recorded their first demo, The Forbidden . After the recording, the band finds their bassist Erlend Caspersen. A year later, the group will record their second demo, "Church of Deviance" and in December 2001, Spawn of Possession signs a contract with the label Unique Leader Records.
In June 2002, after six months of composition, Spawn of Possession began recording his first studio album, Cabinet . The band finished recording at Pama Studios with producer and engineer Magnus Sedenberg (who had already worked on their demos). The Cabinet registration runs smoothly and the group gets the expected result. A tour is organized afterwards, starting with four weeks in Europe with Disavowed, Vile, Inhume and Mangled. A second tour, in North America, for six weeks follows with Severed Savior, Pyaemia and Gorgasm. Spawn of Possession records a total of 27 concerts that year >>>. After his American tour, Spawn of Possession participates in another tour, the No Mercy festival, with bands like Cannibal Corpse, Hypocrisy, Kataklysm, Exhumed, Vomitory and Carpathian Forest. After this tour, the group plays in summer festivals such as Fuck the Commerce (Germany), Stonehenge (Norway), Grind You Mother (Italy) and Mountains of Death (Switzerland).
On October 24, 2005, the band signs to the label Neurotic Records>. The successor of the first album is Noctambulant, recorded in July 2006 for Neurotic Records. In 2009, Christian Muenzner and Matthew Chalk join Spawn of Possession>.
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https://gprotab.net/en/tabs/spawn-of-possession
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14873218
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1/3 Third Avenue
West Moonah, Tasmania, 7009
Property Type: Unit
2 1 1
West Moonah a stratum property with many advantages. It is just one street away from the Moonah boundary giving you better access to 3 major shopping areas plus a regular bus route nearby and only a short walk to a local shop.
You will be impressed with the well designed living areas showing good space. The generous kitchen is central to a layout for 3 living zones that could give a lounge, a dining plus a separate sitting space or reading zone or study space. There is plenty of room for wall units or cabinets.
A sundeck opens to easy care level lawns.
The two bedrooms with impress with full wall built-ins and both are a queen size.
There is a separate bathroom with separate toilet. The laundry is also separate off the kitchen.
The remote controlled garage has been designed with an alcove suitable for workshop or for storage.
A quality fit out is included with a nice surprise. Only 2 other individually designed villas (one sold) share this space.
Cottages like this are getting harder to find.
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https://moanesnorthside.com.au/property/1-3-third-avenue/
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14873219
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https://scholarstore.in/collections/noire
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14873220
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My name is Shyam Sundar Aduvala and I am work as a Software Professional in the Private Sector. I have completed my B.Tech.. I have been raised up in a Middle Class, Nuclear Family with Traditional Values. I'm from Mancherial, Telangana
My name is Ravikumar Goli and I work in the Private Sector as a Software Professional. I belong to a Middle Class, Joint Family with Traditional Values. I have completed my BE in Electronics and Telecommunications.
I have done my Bachelors degree and I am employed in a Private Sector as a Software Professional in Chennai. Now I'm working in client location, which resides in UK. So, now I'm staying in UK. I come from a Middle class, Nuclear family background with Traditional values.
I am currently working as a software professional in private sector, after having completed my master's degree. I come from an upper middle class, nuclear family with moderate values presently living in Edinburgh.
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https://www.padmasalimatrimony.com/united-kingdom-software-professional-grooms
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14873221
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The Voices of Rivers
by Matthew Dickerson
*Shop in our store. You will save 20% off your entire order with coupon code INDIESTRONG. In addition, you will support the ideas and culture beyond the mainstream!
Plus, as always, you’ll receive free shipping on orders over $40.00
Dickerson’s lovingly crafted narratives take us to waters from sockeye spawning streams of Alaska’s Lake Clark and Katmai National Parks, to Rocky Mountain rivers in the national parks and forests of Montana and Wyoming, to the little brook trout creeks in his home waters of Maine. Along the way we will fall in love with arctic streams, glacial rivers flowing green with flour, alpine brooks tumbling out of melting snow, and little estuaries where lobsters and brook trout swim within a few yards of each other; with wide deep lakes, little mountain tarns with crystal clear water, and tannin-laden beaver ponds the color of tea. The narratives are creative, personal, and compelling, yet informed by science and history as well as close observation and the eye of a naturalist. The characters in the stories are fascinating, from fly fishing guides to fisheries biologists to wranglers to Dickerson himself who often explores the rivers with a fly rod in hand, but whose writing transcends any sort of fishing narrative. But the most important characters are the rivers themselves whose stories Dickerson tells, and whose music he helps us to hear.
Advance Praise for The Voices of Rivers
For the earnest fly fisherman, life on earth is measured by encounter, not only with the cutthroat or the brookie, but with the big story being written beneath all things. Matthew T. Dickerson stewards the whole of the world through his insistence on direct experience with the primal domain and, The Voices of Riversis water-marked with the cultivated sensibilities of a devoted guide. I would fish with him any day of the week.
―James Scott Smith, author of Water, Rocks and Trees
The Voices of the River takes you to some of our countries most precious places and immerses you, not only in its rivers, but also its mountains and forests. You feel the water rush by, watch the wildlife and touch the earth, today, and with an appreciation and urgency to protect these grand yet vulnerable places. Matthew Dickerson writes with an Aldo Leopold-esque ability to describe his surroundings and make you treasure these public places. This book is a must-read, surely for anglers who take pleasure in casting for dolly varden, brook trout and other native fish, and for those who care about the health of our peaks, woodlands and waterways. More importantly, this book is for those disconnected from our wild lands and water by distance or desire, or those who simply don’t think about it. After reading The Voices of the River, you will.
―Lisa Ballard, Three-time Emmy-winning producer/host, Wildlife Journal (PBS); Past-president, Outdoor Writers Association of America
Matthew Dickerson combines a boyish delight in fishing with a very adult understanding of the plight of our native fisheries from Maine to Alaska. And the perspicacity of his prose is a great source of delight to us all, fishers and non-fishers alike. Whether pursuing brook trout or Dolly Varden, Dickerson knows both the thrill of the cast and the agony of horribly compromised habitat. We are all the more gleeful and sadly wiser for his efforts.
―Paul J. Willis, author of Deer at Twilight: Poems from the North Cascades
If Izaak Walton’s Compleat Angler deserves credit for inspiring the rich literature of fly-fishing, Matthew Dickerson’s The Voices of Rivers immediately merits a place at the current end of that enticing shelf. In addition to Dickerson’s vivid accounts of fishing for trout (mostly) in the rivers of Colorado, Montana, Alaska, and Maine, his new book also conveys an thoughtful and informative perspective on trout ecology and conservation and the importance of public lands for the health of our earth. His highly engaging voice ties this all together with its narrative energy, excitement, and humor. Dickerson’s approach to fishing is in most cases catch-and-release. But this book is definitely a keeper.
―John Elder, author of Frog Run and Reading the Mountains of Home
His previous narrative non-fiction nature writing includes several books about rivers and the trout that dwell in them : Downstream: Reflections on Brook Trout, Fly Fishing, and the Waters of Appalachia, Trout in the Desert: on Fly Fishing, Human Habits, and the Cold Waters of the Arid Southwest, and A Tale of Three Rivers: of Wooly Buggers, Bowling Balls, Cigarette Butts, and the Future of Appalachian Brook Trout. His most recent novel is a work of medieval historical fiction titled The Rood and the Torc, set in 7th-Century Europe and inspired by a fragment of the medieval poem Beowulf. He is also the co-author of Ents, Elves, and Eriador: the Environmental Vision of J.R.R.Tolkien, Narnia and the Fields of Arbol: the Environmental Vision of C.S.Lewis, and From Homer to Harry Potter: a Handbook of Myth and Fantasy.
Dickerson has also written essays for several periodicals ranging from literal journals to fly fishing magazines, including: Written River, Image, The Other Journal, Middlebury Magazine, Books and Culture, Creation Care, Eastern Fly Fishing, and The Drake. He is a professor at Middlebury College in Vermont where he has had affiliations with the Computer Science Department, Environmental Studies Program, Writing Program, and the New England Young Writers Conference at Bread Loaf.
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https://homeboundpublications.com/the-voices-of-rivers-by-matthew-dickerson/
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Coenen, P., Willenberg, L., Parry, S., Shi, J. W, Romero, L., Blackwood, D., Maher, C., Healy, G. N, Dunstan, D. & Straker, L. (2018). Associations of occupational standing with musculoskeletal symptoms: a systematic review with meta-analysis. British Journal of Sports Medicine,52(3), K. Khan. 176-183. United Kingdom: B M J Group. Retrieved from https://doi.org/10.1136/bjsports-2016-096795
Objective: Given the high exposure to occupational standing in specific occupations, and recent initiatives to encourage intermittent standing among white-collar workers, a better understanding of the potential health consequences of occupational standing is required. We aimed to review and quantify the epidemiological evidence on associations of occupational standing with musculoskeletal symptoms. Design: A systematic review was performed. Data from included articles were extracted and described, and meta-analyses conducted when data were sufficiently homogeneous. Data sources: Electronic databases were systematically searched. Eligibility criteria: Peer-reviewed articles on occupational standing and musculoskeletal symptoms from epidemiological studies were identified. Results: Of the 11 750 articles screened, 50 articles reporting 49 studies were included (45 cross-sectional and 5 longitudinal; n=88 158 participants) describing the associations of occupational standing with musculoskeletal symptoms, including low-back (39 articles), lower extremity (14 articles) and upper extremity (18 articles) symptoms. In the meta-analysis, ‘substantial’ ( > 4 hours/workday) occupational standing was associated with the occurrence of low-back symptoms ( pooled OR (95% CI) 1.31 (1.10 to 1.56)). Evidence on lower and upper extremity symptoms was too heterogeneous for meta-analyses. The majority of included studies reported statistically significant detrimental associations of occupational standing with lower extremity, but not with upper extremity symptoms. Conclusions: The evidence suggests that substantial occupational standing is associated with the occurrence of low-back and (inconclusively) lower extremity symptoms, but there may not be such an association with upper extremity symptoms. However, these conclusions are tentative as only limited evidence was found from high-quality, longitudinal studies with fully adjusted models using objective measures of standing.
Mary MacKillop Institute for Health Research
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https://researchbank.acu.edu.au/fhs_pub/8480/
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14873223
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Stalybridge St Paul’s made the short trip to Woodley on Saturday as the weather finally allowed for a guaranteed game.
Having won the toss and elected to bat, regular wickets fell all through the innings as Stalybridge’s shot selection left a lot to be desired. Only a brief Rob Mallett blast of 22 managed to nudge the score past hundred, which left Stalybridge with only a glimmer of hope.
A few early-innings wicket in Woodley’s reply showed a bit of fight but 105 was way too low a total as Woodley passed their target with 4 wickets down.
On Sunday, Stalybridge then travelled to Birch Vale in the first round of the cup. A more-spirited batting display meant Stalybridge set 153, with opener Harwick (26), Barnes (20), and a 50 partnership between Brownhill (23) and Mike Mallett (27).
In reply, Stalybridge had Birch Vale struggling at 60 for 5, Gary Sandiford standing out with 3 quick wickets. Vale’s two veteran batters then got together however and pushed the run-rate up to expertly guide them to victory in a game that looked like it was going to be very tight at drinks. Another defeat but certainly positive signs as Stalybridge slowly get into the swing of things.
In contrast. Stalybridge 2nds showed the 1sts how it was done with 2 victories, over Buxworth on Saturday and Birch Vale on Sunday. Ant Hunter scoring 33, veteran Pete Coxon and Bashir picked up 3 wickets each. This was followed by another comprehensive victory in the cup on Sunday. This time Coxon picked up 4 wickets with Chris Gledhill also chipping in with 4 including a 3 wicket maiden.
This Saturday sees the 1st finally at home vs Charlesworth, with the 2nds travelling to Compstall. 1.30 start.
Stalybridge 2nds opened the batting after losing the toss to a 10 man Buxworth, with a solid Mike Brownesque performance from Anthony Hunter, with 33 runs from 99 deliveries, before the rest of the team collapsed with just Gary Sandiford and Keith Bowers making double figures (just) with 17 and 11 respectively, leaving Brian Stone’s men’s innings 6 runs short of a batting point, mainly down to a good bowling performance from Buxworth’s young bowler Marcus Page who bowled a respectable 4-26 in 10 overs.
With just 94 on the board, it looked an unlikely task to take anything from the match, but with said bowler Page having to drop out of their batting, Buxworth were subsequently reduced to nine men, which, between Mudi Bashir (3-14 5M 10O), Pete Coxon (3-21 6M 10O), Gary Sandiford (1-4 1M 2O) and Faz Hussain (1-0 1M 1.3O) managed to knock over in short order keeping Buxworth to a innings total of just 59, with only Ken Bradbury and Alan Reynolds making double figures for the Derbyshire side with 18 and 11 between them.
The 2nds next match is tomorrow when they play the rescheduled Hawke Trophy match against Birch Vale and Thornsett CC again at home, who incidentally are the same team they’ll be playing at the next home game two weeks from now, with Compstall CC away in-between on the 14th.
Stalybridge St Paul’s started their adventure into the Derbyshire and Cheshire league with a trip to the beautiful little ground of Hayfield.
Skipper Richard Wright won the toss and decided to bat on a surprisingly hard wicket considering the previous week’s weather, with Stalybridge hoping to take advantage of the small boundary. Advantage was not really taken however as the innings ended on 169 which seemed well short of a competitive total on such a small ground. Wright (28), Richard Wilde (24), debutant Khalid Akram (39) and Jamie Brownhill (21) all made starts but both a failure to convert these starts into higher scores and combined with a late-order collapse, meant Stalybridge were a touch disappointed. The runs were on the board however which did give at least a glimmer of hope.
Hope however was short-lived as the impressive Hayfield opener quickly got to grips with the bowling and hit a quickfire 70. This took the game away from Stalybridge very early on, which also wasn’t helped by losing opening bowler Fish with a suspected torn hamstring, as Hayfield eventually passed the total with the loss of just one wicket.
Stalybridge 2s also slipped to defeat by 10 runs v Whaley Bridge. Pete Coxon picked up 4 wickets, with Faz Hussain and Ant Hunter making 30-odd with the bat.
A slightly disappointing start but the first season in a new league is always going to be a learning curve and it at least felt very refreshing not travelling home from the depths of Cheshire. Stalybridge 1sts are at home this Saturday (1.30) vs High Lane with the 2nds facing the same opposition.
The 2nds opened the new campaign at home on a sunny but bitterly cold afternoon with a narrow defeat to a 10 man Whaley Bridge 2nd XI, failing to overcome their opening innings score of 174 all out, by reaching just 163 before the final wicket of Graham Stone’s questionable LBW decision that saw a bruise just below his hip be deemed low enough to warrant his departure.
Having scored for the club for just over 4 1/2 years without a “retired injured” before, it was therefore appropriate that there’d be two in one game, with both Whaley Bridge’s David Lomax, and Stalybridge’s Faz Hussain both having to leave the field, only to return later on when fit, as there doesn’t seem to be any provision in the rulebook for having a runner.
Notable batting performances from Whaley Bridge’s keeper Michael Madden and bowler Ivan Heathcote with 60 and 51 respectively, while Staly’s Pete Coxon managed 37 as their top scorer.
Pete also topped Stalybridge’s bowling performance, with 4 wickets for 34 runs, but Whaley Bridge’s Colin Wild improved on that in the second innings with 4 wickets for just 9 runs, both over the maximum twelve overs.
The only other thing of note, was the dubious counting skills of the pavilion end umpire, who by his own admission was scoring his first game of cricket ever, but had eleven overs with 7 balls played, one of which was 8 balls long, but perhaps that could be attributed to the returning ball from the opposite end that bowler Pete Coxon directed onto the umpires nose!
The updated league table can be viewed here or on the DCCL website directly, and the 2nds next match involves a short trip up the A6 against High Lane CC’s 2nd XI.
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https://www.sspcc.co.uk/page/9/
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14873224
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Some 600 containers destined for Uganda are being held at the Kenyan port following the introduction of a cash bond tax. The chairman of the Kampala Traders Association announced last week that the association had resolved to suspend using Mombasa in the interim, reports New Vision (Kampala).
In addition, importers say they will take legal action against the Kenya Revenue Authority (KRA) which has issued a directive instructing importers to lodge either a cash bond equivalent to the value of the imported goods or a bank guarantee to the same value. This must be deposited before the goods being imported can be cleared.
The directive has affected not only the 600 containers waiting at the port but imports of motor vehicles and sugar.
Uganda’s trade minister, Amelia Kyambadde said she had been informed by the Uganda business community that the KRA, under notice CUS/L&A/LEG/1 had made a unilateral decision on a requirement for a cash bond or bank guarantee on transit sugar and motor vehicles above 2000cc.
Ugandan authorities say the action by the KRA directive constitutes another non-tariff barrier imposed by Kenyan authorities on its transit cargo and contravenes East African Community Customs Union protocol and decisions reached by the Council of Ministers in March 2012 on removal of non-trade barriers in the community.
“If Kenya needs an instrument to regulate regional trade in sugar and other products, a cash bond is not the instrument to apply,” said Kyambadde. Sources: Ports.co.za / New Vision (Uganda).
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https://mpoverello.com/2012/10/02/ugandan-importers-to-boycott-mombassa/
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-AASTHA MADAAN, ESQ. MADAAN LAW
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14873226
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Meet the Team
Dr. John Emhardt
Dr. John grew up in Indianapolis, IN and received his bachelor’s degree from DePauw University. After completing his undergraduate degree, Dr. John obtained a master’s degree in Biology from Purdue University.
Dr. John attended Indiana University Dental School in Indianapolis where he discovered his passion for pediatric dentistry. He continued his dental education by completing his pediatric dental residency at the Indiana School of Dentistry and Riley Hospital for Children in Indianapolis. He received advanced training in caring for medically complex patients and those with special healthcare needs. He also completed a master’s in science in dentistry for his research, “Significant Factors Related to Failed Pediatric Dental General Anesthesia Appointments at a Hospital Based Residency Program”.
During his residency, he was selected to participate in the Leadership Education in Neurodevelopmental and Related Disabilities (LEND) program, and during his second year he served as Chief Resident. Upon completion of his training, he received the prestigious Ralph E. McDonald Scholar Award for his outstanding performance in pediatric dentistry.
After his residency, Dr. John was selected for the Indiana Dental Association’s AIR Leadership Program, and is focused on promoting children’s oral health at a local and state level. He is part-time faculty at Riley Hospital’s pediatric dentistry residency program, and he is board certified by the American Board of Pediatric Dentistry.
Dr. John’s safari themed office was inspired by his trip to Kenya in 2010 when he had the opportunity to travel to Eldoret, Kenya during his first year of dental school. In Eldoret, he partnered with the Moi University School of Dentistry to provide oral health screenings and to identify water sources with high levels of fluoride. He enjoys playing tennis, reading, mountain biking and cheering on the Colts, Pacers and Indy Eleven!
Dr. Alexander Voris
Welcome, Dr. Alex!
Dr. Alexander Voris is from Fishers, IN. He attended Indiana University in Bloomington, IN where he obtained a BS in biology, and he received his DDS at the Indiana University School of Dentistry. He is currently finishing up a two-year residency and Master’s degree in Pediatric Dentistry from Indiana University at Riley Hospital for Children. Dr. Alex is thrilled to join the team at Emhardt Pediatric Dentistry! He cannot wait to help grow healthy smiles for the kids of Shelbyville and the surrounding communities!
Dr. Alex is a member of the American Academy of Pediatric Dentistry, the American Dental Association, and the Indiana Dental Association.
Dr. Alex has loved working with children for as long as he can remember. As a child, he experienced a lot of dental and orthodontic treatment. From these experiences, Dr. Alex understands how the dental office can be a scary place for patients. That understanding is why it is so important for him to create a fun, safe, compassionate, and educational environment for all his patients and their families. Dr. Alex wants everyone to have confidence in their smile and to love going to the dentist!
In his free time, Dr. Alex enjoys running, playing tennis, trying new restaurants, and traveling. Dr. Alex lives in Zionsville with his family.
Jeanette is our office manager and is well versed in front office coordination. If you ever have a specific insurance question or scheduling conflict, please ask for Jeanette when calling!
She began her career in the pediatric dental field over 30 years ago on the East side of Indianapolis. She loves to interact with our young patients and families. She will be happy to assist you and your family in any way to make your experience a great one!
Jeanette and her husband Steve have been married for 34 years and she has two children Lynnette and Bernadette and two grandchildren. She feels fortunate to have lived in Shelby County for the last twelve years. She loves spending time with family and friends and she enjoys sewing, hiking, camping, and pretty much anything outdoors.
Diana is our Dental Hygienist who graduated in 2014 from Ivy Tech in Anderson. She truly finds it rewarding caring for our patients, easing their fears, and setting them up for a lifetime of great oral hygiene. She found her passion in pediatric dentistry since graduating.
Diana moved to Shelbyville in 2009 after marrying the love of her life Daryl Thomas. Together they have 3 daughters named Mia, Ezri, and Giselle. Diana enjoys spending time with family, baking, going to church, and tackling extreme DIY projects like building their home from the ground up!
Britney is one of our amazing dental assistants who also helps at our front desk. She has worked in the dental field for over 13 years, with experience in general, oral surgery, and 2 years as an orthodontic assistant. She is excited to now call Emhardt Pediatric Dentistry her home.
Britney lives in Fairland, IN with her husband Tim, daughter Taylor, and son Tucker. Britney and her family love spending time with friends cooking out, around a campfire, or at a racetrack. They are proud members of the Fairland community where Tim serves as a volunteer firefighter.
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https://www.emhardtpediatricdentistry.com/about-us/
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what? haha no, there are no ill effects to the motor from installing motor mounts. they're not solid mounts, they still give quite a bit, particularly the inserts. If it's really bad your mount may be broken. They are made of very bad material and if broken could allow the motor to twist around and potentially hit the firewall. either jack up the car or pull one tire up on the curb and slide under there and check it out.fliphandywork said:I have a set of Prothane front mounts but I heard that if I install them without getting the idle raised it will knock due to their stiffness. Is this true?
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https://www.focusfanatics.com/threads/loud-pop-when-shifting-hard.7936/
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14873228
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- Research article
- Open Access
Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection
BMC Medicine volume 8, Article number: 13 (2010)
There are currently no accurate serum markers for detecting early risk of colorectal cancer (CRC). We therefore developed a non-targeted metabolomics technology to analyse the serum of pre-treatment CRC patients in order to discover putative metabolic markers associated with CRC. Using tandem-mass spectrometry (MS/MS) high throughput MS technology we evaluated the utility of selected markers and this technology for discriminating between CRC and healthy subjects.
Biomarker discovery was performed using Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS). Comprehensive metabolic profiles of CRC patients and controls from three independent populations from different continents (USA and Japan; total n = 222) were obtained and the best inter-study biomarkers determined. The structural characterization of these and related markers was performed using liquid chromatography (LC) MS/MS and nuclear magnetic resonance technologies. Clinical utility evaluations were performed using a targeted high-throughput triple-quadrupole multiple reaction monitoring (TQ-MRM) method for three biomarkers in two further independent populations from the USA and Japan (total n = 220).
Comprehensive metabolomic analyses revealed significantly reduced levels of 28-36 carbon-containing hydroxylated polyunsaturated ultra long-chain fatty-acids in all three independent cohorts of CRC patient samples relative to controls. Structure elucidation studies on the C28 molecules revealed two families harbouring specifically two or three hydroxyl substitutions and varying degrees of unsaturation. The TQ-MRM method successfully validated the FTICR-MS results in two further independent studies. In total, biomarkers in five independent populations across two continental regions were evaluated (three populations by FTICR-MS and two by TQ-MRM). The resultant receiver-operator characteristic curve AUCs ranged from 0.85 to 0.98 (average = 0.91 ± 0.04).
A novel comprehensive metabolomics technology was used to identify a systemic metabolic dysregulation comprising previously unknown hydroxylated polyunsaturated ultra-long chain fatty acid metabolites in CRC patients. These metabolites are easily measurable in serum and a decrease in their concentration appears to be highly sensitive and specific for the presence of CRC, regardless of ethnic or geographic background. The measurement of these metabolites may represent an additional tool for the early detection and screening of CRC.
Colorectal cancer (CRC) mortality remains one of the highest among all cancers, second to only lung cancer (Canadian Cancer Statistics, 2008). Despite the known benefits of early detection, screening programmes based on colonoscopy and fecal occult blood testing have been plagued with challenges such as public acceptance, cost, limited resources, accuracy and standardization. There is consensus in the field that the use of colonoscopy alone for CRC screening is not practical , and that a minimally-invasive serum-based test capable of accurately identifying subjects who are high risk for the development of CRC would result in a higher screening compliance than current approaches and better utilization of existing endoscopy resources [1–3]. Although there have been multiple reports of altered transcript levels [4–11], aberrantly methylated gene products [12–14] and proteomic patterns [15–18] associated with biological samples from CRC patients, few if any have advanced into clinically useful tests. This may be due to a number of reasons including technical hurdles in assay design, challenges obtaining reproducible results, costs and lengthy regulatory processes. Furthermore, most of the tests currently used or in development are based upon the detection of tumour-specific markers and have poor sensitivity for identifying subjects who are either very early stage, or are predisposed to risk but show no clinical presentation of disease.
Although causal genetic alterations for CRC have been well characterized, the number of cases due to adenomatous (APC) and hereditary nonpolyposs colorectal cancer are less than 5% of the total, with approximately 15% claimed to be attributable to inheritable family risk likely due to complex patterns of low penetrance mutations which have yet to be delineated . The fact remains that approximately 80% of CRC cases are thought to arise sporadically, with diet and lifestyle as key risk factors [20, 21]. In addition, an individual's microbiome is intricately linked to their gastrointestinal physiological status and may itself be involved as a risk factor . Given that metabolism is heavily influenced by both diet and lifestyle and that the microbiome contributes its own metabolic processes, it is surprising that there has been little effort aimed identifying metabolic markers as risk indicators of CRC. This may, in part, have been due to the lack of platform technologies and informatics approaches capable of comprehensively characterizing metabolites in a similar way that DNA microarrays or surface-enhanced laser desorption ionization can characterize transcripts or proteins, respectively.
Recently, however, there have been rapid advances made in mass spectrometric-based systems which can identify large numbers of metabolic components within samples in a parallel manner [23–25]. Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) is based upon the principle that charged particles exhibit cyclotron motion in a magnetic field, where the spin frequency is proportional the mass . FTICR-MS is known for its high resolving power and capability of detecting ions with mass accuracy below 1 part per million (ppm). Liquid sample extracts can be directly infused using electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) without chromatographic separation , where ions with differing mass to charge (m/z) ratios can be simultaneously resolved using a Fourier transformation. Using informatics approaches, spectral files from multiple samples can be accurately aligned and peak intensities across the samples compared . High resolution also enables the prediction of elemental composition of all ions detected in a sample, providing a solid foundation for metabolite classification and identification, as well as the ability to construct de novo metabolic networks [23, 27]. The combination of liquid extraction, flow injection, high resolution and informatics affords a unique opportunity to broadly characterize the biochemical composition of samples, with no a priori knowledge about the sample itself, to a degree which was not previously possible. This 'non-targeted' approach has the advantage of detecting novel compounds and is therefore ideally suited for biomarker-driven discovery applications. Using a MS-based discovery platform for metabolic biomarker identification also has the added advantage of straightforward translation into a quantitative method based upon triple-quadruple multiple-reaction-monitoring (TQ-MRM), similar to the clinical methods used to screen for inborn errors of metabolism .
Here we report on the application of this technology for characterizing the serum metabolomes of treatment-naive CRC patients and healthy asymptomatic subjects. A specific metabolic perturbation was discovered in the serum of CRC patients compared to controls in three independent and unrelated sets of samples (total n of 222). We further verify the perturbation using a tandem MS (MS/MS) approach in two additional independent case-control populations totalling 220 subjects. Implications of the findings for CRC screening are discussed.
Patient sample selection
Clinical samples used for the first discovery project were obtained from Genomics Collaborative, Inc (GCI, MA, USA), while samples for the second discovery project and one validation project were obtained from Seracare Lifesciences (MA, USA). These companies specialize in the collection and storage of serum and tissue samples specifically for research purposes. Samples were collected, processed and stored in a consistent manner by teams of physicians as part of a global initiative using standardized protocols and operating procedures. Collection protocols for GCI and Seracare Lifesciences were approved by the Western Institutional Review Board and all samples were properly consented. The inclusion criterion for patient sample selection from the GCI and Seracare biobanks for both the discovery and validation cohorts was that the serum be taken prior to any form of treatment, including surgery, chemo or radiation therapies. All samples were accompanied by detailed pathology reports which were independently verified by certified pathologists at GCI and Seracare. The GCI discovery sample set included serum samples from 40 pre-treatment CRC patients and matched 50 controls; the Seracare discovery set included samples from 26 pre-treatment CRC and matched 25 controls, and the validation Seracare set included 70 pretreatment CRC and matched 70 controls. The discovery samples provided by Osaka Medical University (Osaka, Japan) included 46 pre-surgery CRC patients matched 35 controls which were prospectively collected according to the standard collection protocol of the institution and were properly consented. Study protocols were performed according to the ethical guidelines set by the committee of the three ministries of the Japanese Government. The samples for the Chiba, Japan, validation population, which included 40 pre-surgery CRC patients and 40 matched controls, were also prospectively consented and collected under an ethics reviewed protocol approved by the Institutional Review Board of Graduate School of Medicine, Chiba University. A summary of the populations including disease staging is shown in Table 1. All samples were processed and analysed in a randomized manner and the results unblinded following analysis.
Serum samples were stored at -80°C until thawed for analysis and were only thawed once. All extractions were performed on ice. Serum samples were prepared for FTICR-MS analysis by first sequentially extracting equal volumes of serum with 1% ammonium hydroxide and ethyl acetate (EtOAc) three times. Samples were centrifuged between extractions at 4°C for 10 min at 3500 rpm and the organic layer removed and transferred to a new tube (extract A). A 1:5 ratio of EtOAc (extract A) to butanol (BuOH) was then evaporated under nitrogen to the original BuOH starting volume (extract B). All extracts were stored at -80°C until FTICR-MS analysis.
For analysis under negative ESI conditions, sample extract B was diluted 10-fold in methanol:0.1% (v/v) ammonium hydroxide (50:50, v/v) prior to direct infusion. For APCI, extract A was directly injected without diluting. All analyses were performed on a Bruker Daltonics APEX III FTICR-MS equipped with a 7.0 T actively shielded superconducting magnet (Bruker Daltonics, MA, USA). Samples were directly injected using ESI and APCI at a flow rate of 600 μL per hour. Ion transfer/detection parameters were optimized using a standard mix of serine, tetra-alanine, reserpine, Hewlett-Packard tuning mix and the adrenocorticotrophic hormone fragment 4-10. In addition, the instrument conditions were tuned to optimize ion intensity and broad-band accumulation over the mass range of 100-1000 atomic mass units (amu) according to the instrument manufacturer's recommendations. A mixture of the above mentioned standards was used to internally calibrate each sample spectrum for mass accuracy over the acquisition range of 100-1000 amu. FTICR data were analysed using a linear least-squares regression line, mass axis values were calibrated such that each internal standard mass peak had a mass error of < 1 part ppm compared with its theoretical mass. Using XMASS software from Bruker Daltonics Inc (CA, USA), data file sizes of one megaword were acquired and zero-filled to two megawords. A SINm data transformation was performed prior to Fourier transform and magnitude calculations. The mass spectra from each analysis were integrated, creating a peak list that contained the accurate mass and absolute intensity of each peak. Compounds in the range of 100-1000 mz were analysed. In order to compare and summarize the data, all detected mass peaks were converted to their corresponding neutral masses, assuming hydrogen adduct formation. A self-generated two-dimensional (mass versus sample intensity) array was then created using DISCOVAmetrics™ software (Phenomenome Discoveries Inc, Saskatoon, Canada). The data from multiple files were integrated and this combined file was then processed in order to determine all of the unique masses. The average of each unique mass was determined, representing the y-axis. A column was created for each file that was originally selected to be analysed, representing the x-axis. The intensity for each mass found in each of the files selected was then filled into its representative x,y coordinate. Coordinates that did not contain an intensity value were left blank. Each of the spectra was then peak-picked in order to obtain the mass and intensity of all metabolites detected. The data from all modes were then merged to create one data file per sample. The data from all 90 discovery serum samples were then merged and aligned to create a two-dimensional metabolite array in which each sample is represented by a column, each unique metabolite is represented by a single row and each cell in the array corresponds to a metabolite intensity for a given sample. The array tables were then used for statistical analysis described in 'statistical analyses' (see Additional File 1).
Full-scan quadruple time-of-flight (Q-TOF) and high performance liquid chromatography (HPLC)-coupled MS/MS spectrometry
Ethyl acetate extracts from five CRC and five normal samples were evaporated under nitrogen gas and reconstituted in 70 μL of isopropanol:methanol:formic acid (10:90:0.1). Ten microlitres of the reconstituted sample was subjected to HPLC (HP 1100 with Hypersil ODS 5 μm, 125 × 4 mm column; Agilent Technologies, CA, USA) for full scan and 30 μL for MS/MS at a flow rate of 1 mL/min. Eluate from the HPLC was analysed using an ABI QSTAR® XL mass spectrometer fitted with an APCI source in negative mode. The scan type in full scan mode was TOF with an accumulation time of 1.0000 s, mass range between 50 and 1500 Da and duration time of 55 min. Source parameters were as follows: ion source gas (GS) 1 80; ion GS2 10; curtain gas (CUR) 30; nebulizer current (NC) -3.0; temperature 400°C; declustering potential (DP) -60; focusing potential (FP) -265; DP2 -15. In MS/MS mode, scan type was product ion, accumulation time was 1.0000 s, scan range between 50 and 650 Da and duration time 55 min. All source parameters are the same as above, with collision energy (CE) of -35 V and collision gas (CID, nitrogen) of 5 psi. For MS3 work, the excitation energy was set at 180 V.
Preliminary isolation of CRC biomarkers and NMR analysis
For the thin layer chromatographic methods, all chemicals and media were purchased from Sigma-Aldrich Canada Ltd (ON, Canada). All solvents were HPLC grade. Analytical thin layer chromatography (TLC) was carried out on pre-coated silica gel TLC aluminum sheets (EM Science, NJ, USA; Kieselgel 60 F254, 5 × 2 cm × 0.2 mm). Compounds were visualized under ultraviolet light (254/366 nm) or placed in an iodine vapour tank and by dipping the plates in a 5% aqueous (w/v) phosphomolybdic acid solution containing 1% (w/v) ceric sulphate and 4% (v/v) H2SO4, followed by heating. NMR spectra were recorded on Bruker Avance spectrometers; for 1H (500 MHz), δ values were referenced to CDCl3 (CHCl3 at 7.24 ppm) and for 13C NMR (125.8 MHz) referenced to CDCl3 (77.23 ppm).
Ethyl acetate extracts of commercial serum (180 mL serum, 500 mg extract) was subjected to reverse phase flash column chromatography (FCC) with a step gradient elution; acetonitrile - water 25:75 to 100% acetonitrile. The fractions collected were analysed by LC/MS and MS/MS. The fractions containing the CRC biomarkers were pooled (12.5 mg). This procedure was repeated several times to obtain about 60 mg of CRC biomarker rich fraction. This combined sample was then subjected to FCC with a step gradient elution; hexane-chloroform-methanol and the fractions collected subjected to LC/MS and MS/MS analysis. The biomarker rich fraction labelled sample A (5.4 mg, about 65%) was analysed by NMR. Sample A (3 mg) was then treated with excess ethereal diazomethane and kept overnight at room temperature. After the removal of solvent, the sample was analyzed by NMR.
Serum samples were extracted as described for non-targeted FTICR-MS analysis, with the addition of 10 ug/mL [13C1]cholic acid to the serum prior to extraction (resulting in a final ethyl acetate concentration of [13C1]cholic acid of 36 nM. The ethyl acetate organic fraction was used for the analysis of each sample. A series of [13C1]cholic acid dilutions in ethyl acetate from Randox serum extracts was used to generate a standard curve ranging between 0.00022 μg/mL and 0.222 μg/mL. 100 μL of sample were injected by flow-injection analysis into the 4000QTRAP™ equipped with a TurboV™ source with an APCI probe. The carrier solvent was 90% methanol:10% ethyl acetate, with a flow rate of 360 μL/min into the APCI source. The source gas parameters were as follows: CUR: 10.0, CAD: 6, NC: -3.0, TEM: 400, GS1: 15, interface heater on. 'Compound' settings were as follows: entrance potential (EP): -10, and collision cell exit potential (CXP): -20.0. The method is based on the MRM of one parent ion transition for each of the C28 molecules (445.3-383.4 Da, 447.4-385.4 Da, and 449.4-405.4 Da) and a single transition for the internal standard (408.3-343.4 Da). Each of the transitions was monitored for 250 ms for a total cycle time of 2.3 s. The total acquisition time per sample was approximately 1 min. All accepted analyses showed R2 correlation coefficients for the linear regression equation of >0.98. [13C1]cholic acid equivalents for each of the three C28 molecules were calculated by determining the percent recovery of [13C1]cholic acid in each sample by dividing the extrapolated concentration by 0.0148 ug/ml (36 nM, the theoretical amount present in the ethyl acetate extract of each sample). Metabolite concentrations represented as [13C1]cholic acid equivalents were then extrapolated, normalized by dividing by the percent recovery and multiplied by appropriate extraction dilution factors to yield a final serum concentration.
FTICR-MS accurate mass array alignments were performed using DISCOVAmetrics™ version 3.0 (Phenomenome Discoveries Inc, Saskatoon, Canada). Statistical analysis and graphs of FTICR-MS data was carried out using Microsoft Office Excel 2007 and distribution analysis of TQ-MRM data and was analysed using JMP version 8.0.1. Meta Analysis (Fisher's inverse chi-square method) was carried out using SAS 9.2 and R 2.9.0. Two-tailed unpaired Student's t-tests were used for determination of significance between CRC and controls. P-values of less than 0.05 were considered significant. Receiver operating curve (ROC) curves were generated using the continuous data mode of JROCFIT http://www.jrocfit.org.
FTICR metabolomic profiling
The experimental workflow for the studies described in this paper is summarized in Figure 1. Non-targeted metabolomic profiles of sera from three independent populations of treatment-naive CRC patients and geographically and ethnically matched healthy controls (summarized in Table 1) were generated over a 24-month period (that is, each study was separated by approximately 12 months). The first study comprised 40 CRC patients and 50 control subjects acquired from Genomics Collaborative, Inc (GCI); the second study comprised 26 CRC subjects and 25 controls acquired from Seracare Lifesciences Inc; and the third study included 46 CRC and 35 controls prospectively collected in Osaka, Japan. In all cases, serum metabolites were captured through a liquid extraction process (see Methods), followed by direct infusion of the extracts using negative electrospray ionization (nESI) and negative atmospheric pressure chemical ionization (nAPCI) on an FTICR mass spectrometer. The resulting spectral data of all the subjects for each study was aligned within 1 ppm mass accuracy, background peaks were subtracted, and a two-dimensional array table comprising the intensities each of the sample-specific spectral peaks was created using custom informatics software (see Methods). Metabolic differences between CRC patient and control profiles for the three independent studies were visualized by plotting the control mean-normalized log ratio peak intensities across the detected mass range as shown in Figures 2A to 2C. In each independent study, a region of spectra between approximately 440 and 600 Da showed peaks consistently reduced in intensity in CRC patients relative to controls (green, yellow, orange and red points in Figure 2). On average, this cluster of masses showed between 50% and 75% reduction in CRC patient serum compared to the respective controls, with p-values of 1 × 10-5 or lower in each study.
The overlap between each of the discovery studies was further investigated by ranking the top 50 masses based upon P-value from each study and comparing them with masses showing a significant difference (P < 0.05 between CRC and controls) in the other studies as shown in Table 2. For example, 46 of the top 50 metabolites (92%) with the lowest p-values in the GCI discovery set were also significant (P < 0.05) in the Seracare 1 dataset, while 31 out of the 50 GCI masses were significant (P < 0.05) in the Osaka dataset. Likewise, the top 50 metabolites in the Osaka study showed 88% and 94% redundancy with metabolites showing P < 0.05 in the GCI and Seracare 1 studies, respectively. These results indicated a very high degree of commonality among significantly differentiated masses across the three studies, and in fact, 63% of the top 50 masses in each study were also present within the top 50 of at least one of the other two studies (see Additional File 2). Of the top 50 rank-ordered masses, only those identified in more than one study were found to exist within the 440 to 600 Da mass range highlighted above and there was not a single peak detected outside this region which was significantly different between CRCs and controls in any two of the studies. Filtering for metabolic differences detected exclusively in all three studies (as well as removal of C13 isotopic peaks and redundant masses detected in both ESI and APCI), resulted in 13 masses representing individual 12C metabolites as shown in Table 3. These represented the most statistically significant and robust discriminators among the three studies. Subsequent molecular formula assignments, as discussed further below, as well as related expression profiles, suggested that the metabolites belonged to a related chemical family.
The relative intensities of the two lowest molecular weight molecules with nominal masses of 446 and 448 are shown in Figure 3A. We observed little to no correlation between the reduction of the metabolites and disease stage (Figures 3A and 3B), and ROC curve analysis resulted in an average area under-the-curve (AUC) of 0.91 ± 0.03 (Figure 3C; individual AUCs shown) across all three studies for all stages combined.
Computational assignments of reasonable molecular formulas were then carried out for the 13 masses identified above, as well as the top 50 for each discovery set shown in Additional File 2. The assignments were based on a series of mathematical and chemometric rules as described previously , which are reliant on high mass accuracy for precise prediction. The algorithm computes the number of carbons, hydrogens, oxygens and other elements, based on their exact mass, which can be assigned to a detected accurate mass within defined constraints. Logical putative molecular formulas were computed for masses in Table 3 (and Additional File 2), resulting in elemental compositions containing either 28, 30, 32 or 36 carbons and four to six oxygen. We used this information in the subsequent section to select appropriate molecules for structural comparison studies. Collectively, the results indicated a consistent 50% to 75% reduction of organically soluble oxygenated metabolites ranging between 28 and 36 carbons in length, in the serum of CRC patients compared to controls.
Selected ethyl acetate extracts of serum from the GCI cohort used in the FTICR-MS work described above were re-analysed using HPLC coupled to a quadrupole time-of-flight (Q-TOF) MS in full-scan APCI negative ion mode. Consistent with the FTICR-MS results, a cluster of peaks between approximately 440 and 600 Da at a retention time of between 16 and 18 min following reverse-phase HPLC was detected in asymptomatic control sera, but was absent from CRC patient serum (Figure 4). Molecular ions from all six C28 biomarkers (m/z 446, m/z 448, m/z 450, m/z 464, m/z 466 and m/z 468) as well as many of the remaining C32 and C36 markers were easily detectable within normal serum. Extracted masses up to 400 Da within the 16-18 min retention time showed similar peak intensities in both populations (Figure 4, region to the right of the box), as did extracted mass spectra at other retention times (not shown), reinforcing the specificity of this depleted metabolic region for CRC patient serum.
Tandem mass spectrometric fragmentation fingerprints were next generated for the six C28 biomarkers (Table 4, see Additional Files 3 4 5 6 7 8) and for the higher C32 and C36 biomarkers (see Additional File 9). The MS/MS and MS3 fragmentation data of the six C28 biomarkers were dominated by peaks resulting from losses of H2O (m/z 427, 429, 431, 445, 447 and 449), losses of two molecules of H2O (m/z 409, 411, 413, 427, 429, 431), losses of CO2 (m/z 401, 403, 405, 419, 421, 423) and losses of CO2 and H2O (m/z 383, 385, 387, 401, 403, 405), indicating the presence of carboxylic acid functionality and two or more hydroxyl groups. The molecular formulae, organic properties of the molecules and the tandem MS data suggested that the metabolites were derivatives or analogues of one or more possible classes of molecules including fat soluble vitamins such as retinol and retinoic acid (vitamin A), calciferols (vitamin D), tocopherols (vitamin E), phylloquinones (vitamin K), steroids or bile acids, or long chain polyunsaturated hydroxy fatty acids. Tandem mass spectrometric fragmentation fingerprints of standards for each of these metabolic classes were therefore generated including 5S,6S-(7E,9E,11Z,14Z)-dihydroxyeicosatetraenoic acid (1), 15S-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid (2) and 8R-Hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoic acid (3), α-tocopherol (4) γ-tocopherol (5), 13-(6-hydroxy-2,7,8-trimethylchroman-2-yl)-2,6,10-trimethyltridecanoic acid (6), 16-(4,5-dimethyl-3,6-dioxo cyclohexa-1,4-dienyl)-2,6,10,14-tetramethylhexadecanoic acid (7), 6-hydroxy-2,7-dimethyl-2-(4,8,12-trimethyltridecyl)chroman-8-carbaldehyde (8), 6-hydroxy-2,7-dimethyl-2-(4,8,12-trimethyltridecyl)chroman-8-carboxylic acid (9), calciferol (10), cholecalciferol (11), ergosterol (12), phylloquinone (13), retinol (14) and 3β,7α-dihydroxy-5-cholestenoic acid (15) (Table 5). The resulting MS/MS data for vitamins A, D, E, K as well as the steroidal molecules (4 - 15) showed no similarity to any of the metabolomic biomarkers; for vitamin E type molecules, all had diagnostic fragments characteristic of their chroman rings (m/z 163, 149, 149, 149, 163 and 179 for 4, 5, 6, 7, 8 and 9 respectively), for vitamin D and analogues, diagnostic fragments formed as a result of the loss of the side chain (m/z 271, 273 and 253, for 10, 11 and 13, respectively), for phylloquinone (13), the diagnostic fragment m/z 187 for the quinone ring system was prominent, for vitamin A (14), the fragment m/z 269 (M + H - H2O) loses the cyclohexyl ring moiety to form a diagnostic m/z 145 for retinol and for 3β,7α-dihydroxy-5-cholestenoic acid (15) the diagnostic retro diels alder fragment at m/z 277 was observed. In addition to this, other carboxylic acid standards with a pregnane ring system, as in 15 (for example, chenodeoxycholic acid and cholic acid), do not show losses of CO2 upon MS/MS fragmentation (not shown). However, MS/MS fragmentation data of hydroxy fatty acid standards 1, 2 and 3 (Table 5) showed peripheral cut ions similar to those produced by MS/MS of the CRC biomarkers, and consistent with what has been described by others for various hydroxylated long-chain fatty acids [29–33]. For example, marker m/z 446 showed peripheral cut ions 427 [M - H - H2O]-, 401 [M - H - CO2]-, 409 [M - H - 2H2O]-, 383 [M - H - CO2 - H2O]- and 365 [M - H - CO2 - 2H2O]- and chain cut ions, 223, 205, 277 as well as others (see Table 5 and Additional File 3). Similar ions were obtained for the other C28, C32 and C36 metabolites (Table 4 and Additional File 9). Collectively, these deductions indicated that the metabolomic markers were not analogues of vitamins A, D, E, K and steroids, but rather long-chain hydroxy fatty acids containing varying degrees of unsaturation. We collectively refer to these metabolites as hydroxylated polyunsaturated ultra long-chain fatty acids (hPULCFAs; where the term 'ultra' has been used to refer to C30 and longer chain fatty acids ).
Next, an enrichment strategy using bulk serum extracts and a two-stage flash column chromatography approach followed by nuclear magnetic resonance (NMR) analysis was carried out to provide further structural verification of the hPULCFAs. First, reverse phase FCC using a water-acetonitrile solvent gradient was performed and the resulting fractions analysed by LC/MS. Fractions containing the hPULCFAs (fraction 9, Additional Files 10 and 11) were pooled and subjected to normal phase FCC using chloroform-methanol mixtures to obtain an approximately 65% rich semi-purified fraction labelled sample A (Additional File 12). LC and MS/MS analyses (MS2 and MS3) data on sample A were used to track and confirm enrichment of the markers. NMR (1H, 13C and 2D) analyses on sample A and its methyl esters revealed resonances and correlations (Table 6) consistent with very long chain polyunsaturated hydroxy fatty acids with observance of some suppression of resonances for hydrogen atoms attached to sp2 carbons.
Independent validation using MRM methodology
Reduced levels of hPULCFAs in the blood of CRC patients was further confirmed using a MS/MS approach (see methods) in two more independent populations. The approach is based upon the measurement of parent-daughter fragment ion combinations (referred to as MRM) for quantifying analytes [28, 35]. We developed an assay to specifically measure semi-quantitatively three of the 28 carbon hPULCFAs with four oxygens (parent masses 446, 448 and 450; C28H46O4, C28H48O4 and C28H50O4, respectively) as described in the methods. The first study comprised 70 treatment-naive CRC subjects and 70 matched controls, all of which were Caucasians from the USA. The [13C1]cholic acid equivalent concentrations of the three 28-carbon hPULCFAs (named according to nominal mass 446, 448 and 450) for each subject are shown in Figure 5A. Significantly lower levels (P < 0.001, actual values shown in Figure 5A) of each of the metabolites was observed in treatment-naive CRC-positive subjects compared to controls. ROC analysis resulted in AUCs of 0.87 ± 0.005 for each of the 28-carbon containing hPULCFAs (Figure 5B). Plotting patients by disease stage showed a slight (but not significant) reduction between stage I and III, with stage IV subjects showing the least reduction (Figures 5C and 5D), albeit it only seven subjects. The corresponding average AUCs of the 28-carbon pool by stage were 0.87 for stage I, 0.88 for stage II, 0.94 for stage III and 0.66 for stage IV.
We next used the MRM method to characterize another independent population of CRC and control subjects from Chiba, Japan. Serum from 40 pre-treatment CRC subjects and 40 controls were analysed and a significant reduction was again observed in the CRC-positive group (Figure 6A). The corresponding average AUC for the three metabolites was 0.97 ± 0.014 (Figure 6B). In this study, a significant correlation with stage was observed (P < 0.05) for all comparisons between stages I, II and III/IV (Figures 6C and 6D). The AUCs by stage were 0.93 for stage I, 0.97 for stage II and 1.0 for stage III/IV (two stage IVs were grouped with stage III; Figure 6D).
We report here on the discovery of novel hydroxylated polyunsaturated ultra long-chain fatty acids containing between 28 and 36 carbons reduced in the serum of CRC patients compared to healthy asymptomatic controls. The utility of non-targeted metabolomics using high resolution FTICR-MS coupled with flow injection technology for biomarker discovery was demonstrated by applying the technology to three independent test populations. In contrast to the 'training/test-set' approach often used by splitting a single sample set in half to validate the performance of biomarkers [36–38], which often relies on complex algorithms (see review ) and can result in bias , we carried out fully independent discovery analyses on three separate sample sets of matched cases and controls of different ethnic backgrounds collected from multiple sites around the world to ensure a high degree of robustness and minimal chance of sampling bias. Of the top 50 metabolic discriminators discovered in the Osaka set, 44 and 47 of these were also significantly changed in the GCI and Seracare sets, respectively. This remarkable inter-study agreement indicates that not only is non-targeted FTICR-MS technology a reproducible biomarker discovery engine, but that disease-related metabolomic changes can be highly conserved across geographic locations and races. The reduction of hPULCFAs in the serum of CRC patients was further validated by translation of the non-targeted FTICR-MS discovery into a simple targeted TQ-MRM method for three hPULCFAs, which was used on two further independent and ethnically diverse case-control test populations. ROC AUCs generated from the TQ-MRM method on the two validation studies were consistent with those based upon the same fatty acids detected in the three FTICR-MS discovery studies (Figures 3, 5 and 6). In total, five independent study populations collectively comprising 222 treatment-naive CRC patient samples and 220 disease-free asymptomatic controls were evaluated using two different analytical methods. Indeed, the likelihood of the reported association between the reduction of hPULCFAs and CRC being a false positive result across the five independent sets of samples is astronomically low. Meta-analysis was performed on the false positive rates using Fisher's Inverse Chi-square Method (; p = P-values of five independent samples, k = five different samples, C = upper tail of the chi-square distribution with 2 k degrees of freedom ( = 18.31))[41, 42]. Based upon the meta-analysis, the resulting P-values for markers 446 and 448 were more significant than the individual P-values, at 2.96 × 10-47 and 8.11 × 10-49, respectively. Although there were differences in the median ages between the CRC and control cohorts in two of the studies, there was no statistically significant trend between age and hPULCFA levels within the individual cohorts and we observed no significant difference between hPULCFA concentrations among the controls from the different populations (not shown). We also observed no differences between genders, and although there were slightly higher BMI levels in the control cohorts for the GCI and Seracare 1 cohorts, the BMIs were matched in the second Seracare validation population suggesting the markers are not related to BMI. A prospective analysis of disease-free subjects equally distributed across various age groups is underway specifically to address any potential age or BMI effects in more detail. Overall our results indicate with a high degree of confidence that a reduction in these metabolites is correlated with the presence of CRC.
The FTICR-MS provided resolution sufficient for confident molecular formula predictions based upon accurate mass in conjunction with extraction, ionization, and statistical correlative information. Although multiple elemental compositions were theoretically assignable to given biomarker masses, only formulas having 28 to 32 carbons, and four to six oxygen were consistently assignable to common masses detected in two or three of the discovery sets. Given a high degree of statistical interaction between the sample-to-sample expression profiles of the hPULCFAs (that is, a high degree of correlation between the relative intensities of the markers across subjects) we suspected they were all part of the same metabolic system and should therefore show related compositions. Detection in negative ionization mode also reduced the likelihood that nitrogen was present in any of the compositions. This information in conjunction with tandem mass spectrometry showing prominent losses of water and carbon dioxide enabled the determination of molecular formulas as shown in Table 3 and Additional File 2. A number of candidate classes of molecules theoretically fitting the molecular formula class were easily excluded using tandem MS. For example, we observed no fragments indicative of condensed ring systems such as those in steroids or vitamin D, and no fragments indicative of chroman ring systems such as those observed in the vitamin E tocopherols. Several other classes of molecules including vitamin K and retinol, and bile acids such as cholic acid and 3β,7α-dihydroxy-5-cholestenoic acid also did not show comparable fragmentation patterns. However, the similarity in fragmentation pattern, particularly in the relative abundances of daughter ions resulting from losses of CO2 and H2O, and chain cut ions from the hPULCFAs to known hydroxy fatty acid standards as well as other fatty acids reported in the literature such as the resolvins and protectins (discussed below), allowed for the identification of the metabolites as hydroxylated polyunsaturated ultra long-chain fatty acids. Examination of the MS/MS data for the C28 series (masses 446, 448, 450, 464, 466 and 448) revealed a consistent 113 Da daughter ion, which we conjecture to represent the carboxy-terminus chain fragment -CH2-CH=CH-CH2-CH2-COOH. In addition, a consistent loss of 54 (-CH=CH-CH2-CH2-) from the [M-(CO2 +H2O)] daughter ion was observed for the 446, 448, 464 and 466, but not the 450 and 468 molecules, suggesting that (1) the 450 and 468 may have a saturated carboxy terminal region and (2), that there are likely no hydroxyl moieties within this region of the molecule. MS/MS data of all the C28 and other markers also did not show the diagnostic fragment obtained with a 1,2-diol motif as observed for 1 (base peak is chain cut ion at m/z 115) and NMR on fractions enriched via flash-column chromatography showed lower than expected integration values obtained for the 1H NMR signals at δ 2.78 (methylene interruptions between double bond carbons) and at δ 5.12 - 5.90 (hydrogen atoms on double bond carbons). Cumulatively these results suggested that the hydroxyl groups in the molecules are likely bonded to the carbon atoms between the sp2 carbons at least seven carbons from the carboxy end. Confirmation of the exact positions of the hydroxyl groups and precise locations of unsaturations in individual hPULCFAs using preparatory HPLC and chemical synthesis is in progress and will be reported in subsequent publications.
Interestingly, the metabolite markers reported in this study represent a human-specific metabolic system. We analysed serum samples from multiple species, including rat, mouse and bovine, as well as multiple different sample sources including numerous cell lines, conditioned media, tumour and normal colonic tissue from patients in the GCI discovery set, and brain, liver, adipose and other tissues from various species, all of which failed to show any detectable levels of these hPULCFAs (results not shown). We also could not detect these molecules in various plant tissues or grains, including policosanol extracts which are rich in saturated C28 and longer-chain fatty acids [43, 44]. This suggests that the molecules may originate from human-specific metabolic processes, such as specific p450-mediated and/or microbiotic processes. The lack of detection in tumour or normal colonic tissue suggests that the metabolites are not 'tumour-derived markers' and, combined with the high rate of association in stage I cancer, it is not likely that the reduction is the result of tumour burden. Analysis of post-surgery samples is currently in progress to address this question. However, the further reduction of levels observed in some late stage Japanese cases (Figure 6) could be explained if lower levels of the hPULCFAs were indeed indicative of progression rate in this group. It is also important to note that in all control groups reported in this paper, subjects were not colonoscopy-confirmed to be free of tumours or advanced neoplasia. Based upon colonoscopy results by Collins et al in average-risk subjects, up to 10% of an asymptomatic population can be positive for advanced neoplasia . Therefore, the ability of these metabolites to discriminate between subjects at risk and not at risk for CRC is likely under-estimated in our results. Studies are currently in progress to evaluate endoscopy-confirmed controls, to assess the effect of treatment on the markers, and to investigate any possible association with various grades of colon pathologies and non-malignant GI disorders as well as other cancers.
Although fatty acids of this length containing hydroxyl groups have never been reported as far as we are aware, they appear to resemble a class of hydroxylated very long-chain fatty acids knows as the resolvins and protectins that originate from the n3 essential fatty acids EPA and DHA, respectively, which are critical in promoting the resolution of acute inflammation. The inability to sufficiently 'resolve' acute inflammation is the leading theory behind the establishment of chronic inflammatory states which underlie multiple conditions including cancer and Alzheimer's Disease . Of particular relevance is the effect of pro-resolution long-chain hydroxy fatty acid mediators on intestinal inflammatory conditions such as irritable bowl disease (IBD), Crohn's Disease, Colitis and colon cancer. Both Resolvin E1 (RvE1) and Lipoxin A4 (LXA4) have been implicated with protective effects against colonic inflammation. RvE1 was shown to protect against the development of 2,4,6-trinitrobenze sulphonic acid-induced colitis in mice, accompanied by a block in leukocyte infiltration, decreased proinflammatory gene expression, induced nitric oxide synthase, with improvements in survival rates and sustained body weight . Similarly, LXA4 analogues have been shown to attenuate chemokine secretion in human colon ex vivo , and attenuated 50% of genes, particularly those regulated by NFκB induced in response to pathogenically induced gastroenteritis . In vivo, LXA4 analogues reduced intestinal inflammation in DSS-induced inflammatory colitis, resulting in significantly reduced weight loss, haematochezia and mortality . Structurally, resolvins and protectins (as well the n6 lipoxins) comprise mono-, di- and tri-hydroxylated products of the parent VLCFAs, catalyzed by various lipoxygenases, cyclooxygenases and p450 enzymes [51–55]. The possibility that the hPULCFAs reported here represent elongation products of these molecules cannot be excluded. Future studies will be required to address the origin, as well as the biological role, if any, that these molecules may play in defending the body against CRC development.
Although we report results from multiple case-control cohorts each having a limited sample size, the average AUC across all the samples reported here was 0.91 ± 0.04, which translates into approximately 75% sensitivity at 90% specificity with little to no disease-stage bias. The real-world screening performance is currently being evaluated through two large ethically approved prospective clinical trials, one in collaboration with the Saskatchewan Cancer Agency and the Saskatchewan Provincial Government (PDI-CT-1; n = 5000), and the other with the University of Calgary (PDI-CT-3 n = 1500). Clinically relevant questions are being addressed, including correlation between hPULCFAs and CRC in a prospective hospital screening environment, correlation with other non-malignant gastrointestinal disorders (such as IBD, Crohn's and colitis), whether there is any correlation with various stages of neoplasia or polyps and family history and whether subjects with low hPULCFA levels show higher incidence rates of CRC than subjects with 'normal' levels over time.
In summary, we have identified a consistent reduction of novel circulating hPULCFAs in CRC patients which could have considerable implications for CRC diagnosis and screening and possibly prevention and treatment. Adherence to currently recommended screening modalities, namely faecal occult blood testing and colonoscopy, is poor due to a number of factors including public acceptance, risk, cost and available resources. The use of a serum-based test to screen the population for subjects who are high risk would focus endoscopy resources on subjects who need it the most, resulting in a higher detection rate, particularly in early stages of the disease. Given the positive prognosis of early-stage therapeutic intervention, it is tempting to speculate that hPULCFA-based screening could one day result in decreased CRC mortality.
We have shown that comprehensive non-targeted metabolomics technology based upon high-resolution FTICR mass spectrometry represents a powerful and robust approach for small-molecule biomarker-driven discovery. Accurate mass measurements combined with conventional MS/MS resulted in the rapid identification of key structural characteristics of the novel metabolites discovered and the assignment of putative chemical structures. The subsequent translation of these metabolite biomarker discoveries into an efficient and clinically viable high-throughput semi-quantitative triple-quadrupole platform represents a significant advancement in the clinical implementation of biomarker discoveries. The reduction of systemic hydroxylated ultra-long chain fatty acids in CRC patients raises intriguing biological and aetiological questions given the large numbers of sporadic CRC cases and the heavy influence of lifestyle and diet on risk. Further research is ongoing regarding the potential role(s) these novel molecules play in CRC progression and whether they have any association with previously established risk factors.
adenomatous polyposis coli
atmospheric pressure chemical ionization
area under the curve
flash column chromatography
Fourier transform ion cyclotron resonance mass spectrometry
high performance liquid chromatography
hydroxylated polyunsaturated ultra long-chain fatty acid
multiple reaction monitoring
tandem mass spectrometry
mass to charge ratio
nuclear magnetic resonance
part per million
surface-enhanced laser desorption ionization
thin layer chromatography
very long-chain fatty acid.
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Ringner M, Peterson C, Khan J: Analyzing array data using supervised methods. Pharmacogenomics. 2002, 3: 403-415. 10.1517/146224184.108.40.2063.
Baggerly KA, Morris JS, Coombes KR: Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments. Bioinformatics. 2004, 20: 777-785. 10.1093/bioinformatics/btg484.
LV H: Meta-Analysis. Journal of Educational Statistics. 1992, 17: 279-296.
Fisher RA: Statistical methods for research workers. 1932, London: Oliver & Boyd, 4
Marinangeli CP, Kassis AN, Jain D, Ebine N, Cunnane SC, Jones PJ: Comparison of composition and absorption of sugarcane policosanols. Br J Nutr. 2007, 97: 381-388. 10.1017/S0007114507336763.
Wang MF, Lian HZ, Mao L, Zhou JP, Gong HJ, Qian BY, Fang Y, Li J: Comparison of various extraction methods for policosanol from rice bran wax and establishment of chromatographic fingerprint of policosanol. J Agric Food Chem. 2007, 55: 5552-5558. 10.1021/jf063623q.
Collins JF, Lieberman DA, Durbin TE, Weiss DG: Accuracy of screening for fecal occult blood on a single stool sample obtained by digital rectal examination: a comparison with recommended sampling practice. Ann Intern Med. 2005, 142: 81-85.
Das UN: Essential fatty acids: biochemistry, physiology and pathology. Biotechnol J. 2006, 1: 420-439. 10.1002/biot.200600012.
Das UN: Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease--but how and why?. Prostaglandins Leukot Essent Fatty Acids. 2008, 78: 11-19. 10.1016/j.plefa.2007.10.006.
Arita M, Yoshida M, Hong S, Tjonahen E, Glickman JN, Petasis NA, Blumberg RS, Serhan CN: Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci USA. 2005, 102: 7671-7676. 10.1073/pnas.0409271102.
Goh J, Baird AW, O'Keane C, Watson RW, Cottell D, Bernasconi G, Petasis NA, Godson C, Brady HR, MacMathuna P: Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo. J Immunol. 2001, 167: 2772-2780.
Gewirtz AT, Collier-Hyams LS, Young AN, Kucharzik T, Guilford WJ, Parkinson JF, Williams IR, Neish AS, Madara JL: Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. J Immunol. 2002, 168: 5260-5267.
Serhan CN: Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. J Periodontol. 2008, 79: 1520-1526. 10.1902/jop.2008.080231.
Schwab JM, Chiang N, Arita M, Serhan CN: Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007, 447: 869-874. 10.1038/nature05877.
Serhan CN, Gotlinger K, Hong S, Lu Y, Siegelman J, Baer T, Yang R, Colgan SP, Petasis NA: Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. J Immunol. 2006, 176: 1848-1859.
Serhan CN: Novel chemical mediators in the resolution of inflammation: resolvins and protectins. Anesthesiol Clin. 2006, 24: 341-364. 10.1016/j.atc.2006.01.003.
Schwab JM, Serhan CN: Lipoxins and new lipid mediators in the resolution of inflammation. Curr Opin Pharmacol. 2006, 6: 414-420. 10.1016/j.coph.2006.02.006.
The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/8/13/prepub
We would like to thank the following individuals for their contributions to this work: Hideaki Shimada, Takeshi Tomonaga and Kazuyuki Matsushita for sample collection, processing and clinical data management at Chiba, Japan.
The following authors are full-time employees and have received salaries from Phenomenome Discoveries Inc, Saskatoon, Canada: Shawn A Ritchie, Pearson W K Ahiahonu, Dushmanthi Jayasinghe, Doug Heath, Jun Liu, Yingshen Lu, Wei Jin, Amir Kavianpour, Yasuyo Yamazaki, Amin M. Khan, Mohammad Hossain, Khine Khine Su-Myat and Paul L Wood. Dayan B Goodenowe is the co-founder, President and CEO, of Phenomenome Discoveries, Inc. Only Dayan B Goodenowe owns shares in the company. Kevin Krenitsky, Ichiro Takemasa, Masakazu Miyake, Mitsugo Sekimoto, Morito Monden, Hisahiro Matsubara and Fumio Numura have no competing financial interests. None of the authors have non-financial competing interests. Phenomenome Discoveries Inc is financing the article processing fees for the manuscript. Shawn A Ritchie and Dayan B Goodenowe are named inventors on submitted patent applications relating to the discoveries disclosed within the manuscript and have both received a salary from Phenomenome Discoveries Inc (the organization named in the patents).
SAR was the group leader, lead author and writer, performed the study design and sample selection, completed all the discovery FTICR-MS data analysis, including statistical analysis, supervised the structural elucidation, MSMS interpretation and overall experimental designs. PWAK performed MS/MS and NMR analysis and interpretation and analysed all comparison MSMS standard data. DJ performed MS/MS and fraction column chromatography enrichment and NMR interpretation. DH developed FTICR-MS analytical methods, including extraction protocols, and helped to develop the TQ-MRM methodology used. JL developed high performance liquid chromatographic methods and analysed samples for HPLC-TOF analysis. YL developed and optimized TQ-MRM methods and analysed validation sample sets. WJ performed and optimized HPLC-TOF and MS/MS analysis and samples, including enriched serum extracts. AK was involved in the optimization of the TQ-MRM methodology, QAQC and analysis of validation (Seracare and Chiba) samples. YY developed the original chromatographic (HPLC) methods used to isolate the hPULCFAs and aided in the experimental design of the Chiba and Osaka sample sets. AMK oversaw the structural elucidation processes including NMR interpretation and MS/MS interpretation. MH aided in MS/MS and NMR data generation and interpretation. KKSM was involved in the biostatistical analysis, including the analysis of HTS data, Fisher analysis and all SAS work. PLW was involved in the interpretation of MS/MS data, NMR data, mechanistic insights into MSMS fragmentation patterns and proposed structural motifs. KK was involved in the sample selection and study design for the genomics collaborative and Seracare Lifesciences sample sets, the selection of matched cases and controls, clinical data organization and verification of disease pathology. IT was involved in the design of clinical trials in Osaka, patient selection and pathology confirmation. MM was involved in the clinical trial design in Osaka, patient selection and discovery analysis, clinical staging, pre-versus post surgery data collection and analysis. MS was the Head of the lower gastroenterological surgery group, Osaka, responsible for patient recruitment and trial design. MM was the group leader at the Osaka Department of Surgery and was involved in the experimental design of the Osaka discovery sample set, data analysis/interpretation and unblinding of data. HM was the head of surgery (for CRC population, Chiba) responsible for the patient enrolment and selection for the Chiba samples. FN was the group leader at Chiba overseeing the entire project, including protocol design and approvals, data analysis and unblinding. DBG was the President and CEO of Phenomenome Discoveries Inc, and oversaw most of the efforts at PDI, was integrally involved in the interpretation of MS/MS data, the development of FTICR methodology, the experimental designs and was also a significant contributor to the format and direction of the manuscript.
Electronic supplementary material
Additional file 2: t -test) of each discovery project. Masses shaded grey were detected in the top 50 in two of the three studies. Indicated are the detected accurate mass, the computationally predicted molecular formula (for masses shaded in grey), the mass difference between the detected mass and mass of the predicted molecular formula in part per million (ppm), the mode of analysis (electrospray ionization; atmospheric pressure chemical ionization), the P-value (based on an unpaired student's t-test) between the average peak intensity of control subjects versus colorectal cancer (CRC) patients and the average peak intensity ratio between CRC patients and controls. (PNG 243 KB)
Additional file 10: Purification process to obtain hydroxylated polyunsaturated ultra long-chain fatty acids (hPULCFA) enriched fractions from human serum. Dried organic extracts of serum were initially purified in a reversed phase flash column chromatography using water/acetonitrile step solvent gradient to obtain semi purified hPULCFA enriched fraction (F9). Several of F9s were combined for a secondary purification step in a normal phase flash column chromatography using hexane/chloroform/methanol step solvent gradient to obtain highly hPULCFA enriched fraction 7 (F7_2). (PNG 141 KB)
Authors’ original submitted files for images
Below are the links to the authors’ original submitted files for images.
About this article
Cite this article
Ritchie, S.A., Ahiahonu, P.W., Jayasinghe, D. et al. Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med 8, 13 (2010). https://doi.org/10.1186/1741-7015-8-13
- High Performance Liquid Chromatography
- Cholic Acid
- Atmospheric Pressure Chemical Ionization
- Hydroxy Fatty Acid
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https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-8-13
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14873229
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Persuasive Letter: Approval and Support for the Act
To Thomas More,
Approval and Support for the Act
I am writing this letter quite sorrowfully, in part due to the fact that I personally feel that you are indeed an honorable man, worthy of reward and praise. Your disapproval of both acts of parliament is justifiable as well as admirable. I have no doubt in my mind that your reasons for refusing to acknowledge the two acts are valid and worthy of consideration. The fact that the King has such low regard for the law that he is quite willing to change the law simply to satisfy his own personal desires is no doubt deplorable. The king is willing to not just divorce his wife, in pursuit of a male heir, but is also willing to walk away from the ordained path of God to do it. The motivations for pursuing these changes are no doubt selfish in your eyes and agreeing to them would amount to a demonstration of utter disrespect for the law and for God.
Further, this decision I understand, weighs heavily on your heart, as your conscience cannot allow you to support a split in the church simply to satisfy simplistic human desires. Amending the law, and denouncing the supremacy of the pope simply to satisfy an individual’s desires, even if it is the king cannot be simple for a principled individual like yourself. Bottom line, no principled individual compromises what they stand for, either for political gain, or for the sake of self preservation.
The issue in question is no doubt one of morals. The bible quite clearly outlines the conditions under which any marriage may be dissolved. The conditions under which the king wishes to dissolve his marriage raises considerable moral questions, more so when one considers the trouble it took to bring about the union in the first place. The marriage in itself was immoral, and required the pope cut a number of corners that have already brought the church into disrepute, allowing the king to divorce and remarry will only further tarnish the church’s image, no morally upright citizen would support such an action.
While I acknowledge that your reasons for not supporting the act are valid, kindly reconsider your position. Philosophically, it is argued that the best course of action for any individual to take, is usually the one that results in the greatest happiness for those involved. As such, the main motivation when taking any particular action, should always be realizing the greatest utility. In this case, your support for the act, would no doubt make the king and his supporters quite happy. It would also ensure that we are reunited as a family, which would also make us very happy. On the other hand, your refusal to support the act has brought immense unhappiness even to you, the best course of action would therefore, be for you to support the act.
Not signing in support of the act, will lead to your untimely death, as the fact that you do not support the act has already led to your arrest and detention. Your friends have already turned against you, and I have no doubt that even more will betray you as long as you keep opposing the act. Although what you have only lost so far is your position and your freedom, your continued opposition to the act will undoubtedly lead to your loss of standing. As a politician, you surely must understand that it never ends well for those who oppose the establishment.
Furthermore, not supporting the act will have negative consequences for your family as well. It is my belief that you would not like to harm your own family, although you must understand that if labeled an outcast and a rebel, our fate, as members of your family is also sealed, as we will also be labeled outcasts and no doubt be excommunicated, or worse still, murdered. If your family disappears, your legacy will also be a distant memory. In fact, you will have no legacy to be remembered for, as no one fondly remembers traitors, your death and our death or disappearance will have been for nothing.
If you support the act, I do understand that to you it will have been an act of cowardice but imagine what it could mean. The king and his henchmen already hold you in such high regard. You would undoubtedly ascend to a position of power within the kingdom. Such a high position would mean that you become a man who wield significant power, which would give you an opportunity to slowly correct and change things; giving you a real opportunity to effect change.
Finally father, supporting the act would not only spare your life, but ours as well. It would mean that our family can be reunited again, and its name would remain intact. Supporting the act would also leave you wiser, as it would also mean that you now understand who you can or cannot trust, and in due course, I have no doubt that you will be able to repay in kind, those that have turned their backs on you. Please do not let pride and your conscience cost our lives, more so one that we are not yet done cherishing, and one as capable as yours, you were meant to effect real change, stay alive and play politics like I know you can.
Your Loving Daughter
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https://www.nursingessayswriter.com/persuasive-letter-approval-and-support-for-the-act/
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14873230
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‘The property down the road is on the market for $750,000 and that property isn’t as good as mine. So my property must be worth around $900,000… do you think we could get that?’
Whilst there is some logic to this argument, it may not be accurate. Firstly, it’s not easy to be objective about one’s own home and secondly, the property down the road hasn’t yet sold so it’s not yet a useful comparison.
A real estate agent will look at ‘comparable sales’ to estimate the sale price of a property. However, with acreage properties it is not always easy to compare apples with apples. We sometimes need to extrapolate to come up with ‘similar sales’. For example, Property 1 may have an extra bedroom but Property 2 has a swimming pool – so we can trade one feature off with another to make a price comparison.
The value of a property is very subjective, so people may have different opinions on how much a property is worth to them. To illustrate, a property located on a busy road may only be worth $400,000 to a family with young children due the traffic noise. But a business owner may pay $550,000 for the same property because it provides extra exposure to passing customers. So a property is worth what someone is prepared to pay!
Market value is defined as:
“the estimated amount for which an asset or liability should exchange between a willing buyer and a willing seller in an arm’s length transaction after proper marketing wherein the parties had each acted knowledgeably, prudently and without compulsion.” International Valuation Standards Committee (IVSC)
There are three traditional approaches to valuing a property:
- comparison approach
- cost approach (land value + cost of construction)
- income approach (eg. for commercial properties)
A real estate agent is not a registered valuer. A valuer can provide a valuation but a real estate agent can only provide a market appraisal. The difference is, a valuation is a legal document that is defensible in court.
Valuers are usually engaged by a bank to ensure the property is worth more than the bank is lending on the mortgage. Obviously the bank wants to protect themselves if the borrower is unable to repay the debt and the property needs to be sold (mortgagee sale).
Valuers have tertiary qualifications, at least two years of experience, and they are registered with the Valuers Registration Board of Queensland. At the end of the day, both real estate agents and valuers rely on comparable sales to estimate the market value of your home.
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https://karlgrossman.com.au/how-is-my-home-valued-2/
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14873231
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Welcome to the BRAVO Center!
Since 1990, BRAVO director Amy Teelin has brought the Baraboo community a fun place to dance, exercise, and perform. Located on the Baraboo River just a few blocks from beautiful downtown, the BRAVO Center offers big-city opportunities in this wonderful small town.
The BRAVO Center is a positive, energetic dance and fitness studio that focuses on providing students with the perfect balance of technique and fun. Dance is a creative form of individual expression and we work to hone the artistry. It is our goal that each dancer who joins the BRAVO family not only has a blast in class, but can also use their skills and knowledge from BRAVO to excel in any performance endeavor.
We pride ourselves in providing our students with professional, quality instruction from trained teachers in a non-competitive, positive atmosphere. Every student is welcomed into the BRAVO family with open arms, regardless of age, ability, or achievement. Whether you're in class just for fun or you're preparing for collegiate programs, our personal and passionate teachers will help your goals.
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https://www.bravocenter.info/?lightbox=dataItem-jqzd4b9x
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14873232
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February 11, 2019
The Birth Defect Surveillance Group, part of ZikaPLAN’s Work Package 8 (Disease Burden and Risk Assessment), announces the launch of the Global Birth Defects website.
The Zika epidemic highlighted the need to build stronger birth defect surveillance systems to improve birth defect prevention and the care of affected children, not only in response to Zika but also other risk factors. Birth defects affect at least 3% of babies in most populations around the world and surveillance is essential to measure the impact of the numerous risk factors that can affect fetal development in early pregnancy. Surveillance provides an evidence base for preventive public health interventions designed to mitigate those risk factors.
This initiative aims to improve and mainstream birth defect (congenital anomaly) surveillance, especially in low resource areas, which are most affected. The website offers a comprehensive, up-to-date inventory of available resources and associated tools for congenital anomaly surveillance and research that can be adapted to local needs and used to determine appropriate public health interventions.
The international committee behind the website is also busy creating a first-of-its-kind App for the description and coding of externally visible birth defects. This App will be freely available and is aimed at enabling frontline healthcare workers in resource-constrained environments to improve and expand their surveillance efforts. Once downloaded onto a mobile device, the App can be used offline, making it more practical for use in places where internet accessibility is limited or intermittent. The committee gathered in London on January 21 & 22, 2019 to finalize the content of this App. Field testing will take place in India, Africa, and Latin America later this year before final enhancements are made. Then the App will be widely released.
Look for updates on Twitter @GlobalBirthDfx
International Committee for Congenital Anomaly Surveillance Tools
- H. Dolk, EUROmediCAT, Ulster University, UK (Chair)
- I. Barisic, EUROCAT, Department of Genetics, Children’s University Hospital, Zagreb, Croatia
- L. Barlow, The Makerere University-John Hopkins University Research Collaboration, Uganda
- L. Botto ICBDMSR, University of Utah, USA
- E. Garne EUROCAT, Lillebaelt Hospital, Denmark.
- P Guatibonza, Latin American Collaborative Study of Congenital Malformations (ECLAMC), Colombia
- C. Halleux, WHO TDR, Geneva, Switzerland
- L. Holmes, Massachusetts General Hospital, Boston, USA and WHO TDR Advisor
- I. Orioli, Latin American Collaborative Study of Congenital Malformations (ECLAMC), Rio de Janeiro, Brazil
- N. Raina, World Health Organization, Regional Office for South East Asia (WHO SEARO), New Delhi, India
- D. Valencia, Centers for Disease Control and Prevention (CDC), Atlanta, USA
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https://zikaplan.tghn.org/news/new-global-birth-defects-website-comprehensive-resources-improve-birth-defect-surveillance/
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14873233
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I’m a little embarrassed to admit it, but I’m a fast eater. Regardless of whether it’s a garden salad or a filet mignon, once I get my hands on my utensils, I start cutting, sticking, and scooping up food at a steady pace. I politely shove it into my mouth and swallow, and then I either move onto the next bite or start multitasking.
In the back of my mind, I see it as a bad habit, a product of absentmindedness, or borderline rudeness, but it has never struck me as something of any spiritual consequence until recently.
It all started last year when I joined a contemplative prayer group that meets once a month and encourages members to practice spiritual disciplines. Quite frankly, I joined the group because my wife insisted, and I didn’t want her to think I was unspiritual; but I wasn’t looking forward to it. I mean, for me, the phrase “spiritual discipline” conjures up memories of miserable attempts to fast and pray while fantasizing about eating Cocoa Pebbles.
Anyway, to my surprise, there are more spiritual disciplines than fasting and praying, although fasting and praying have their place. For example, there’s being silent before God, journaling; there are creative ways to meditate on scripture; and there’s something called consciousness examen.
Consciousness examen is prayer that involves reflecting on our lives and looking for ways the Holy Spirit moved during the day. Basically, it’s a multicolored, spiritual X-ray, an opportunity to relive the day and see where God was at work in the ordinary. If you want some good guidance on it, click here, but here’s how I do it:
- I open myself to gratitude for all kinds of random stuff that blessed me during the day;
- I ask God for help in being real with Him;
- I become aware of the ways I moved with God during the day and the ways I was moved by insecurity or fear;
- I recognize that I’m forgiven for the ways I failed; and
- I invite God to show up and give me the grace to see His activity in my life the next day.
As I walk through a prayerful review of the day, I begin to see that so many of the ordinary moments in the day weren’t ordinary at all – and like a stained glass window, the Spirit’s illumination brings out patterns, colors, and meaning that were invisible in the dull light of my hurried life.
Through this practice, I find myself constantly surprised at how little I engage with my own life, how unaware I am of God, how often I simply go through the motions. And that’s where the spirituality of eating comes in.
I’m starting to realize that I live my life like I eat my food – jamming it in and swallowing, barely tasting it, ungrateful for the preparation, barely aware of the flavors. So I’ve begun slowing down in general, appreciating the surprise run-ins with friends on the street, being fully present for tender, but tight, hugs from my daughter – and yes, I’ve actually been chewing and enjoying my food.
So, for example, the other day I came home and my wife had whipped together one of her staple Puerto Rican dishes. I sat down at the table, prepared to shovel it in, but then I stopped and decided to experience it.
Good. Gracious. The flavor of the fish, tomato base, green olives, potatoes, raisins, and brown rice burst in my mouth, perfectly complementing one another – even the texture was pleasing. Yet somehow, in six years of marriage, I hadn’t really noticed it like I did at that meal. It makes me want to slow down and see what the rest of my meals really taste like, what the rest of my life tastes like.
Basically, I’m developing a taste for the present, a hunger to experience God in the moment – not just when I’m prayerfully reflecting on my day. “Oh, taste and see that the Lord is good! Blessed is the man who takes refuge in him!” (Psalm 34:8).
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https://joshuarogers.com/2014/07/03/eating-just-got-really-spiritual-for-me/
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14873234
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Bowhunting to us is more than a hobby, but a way of life. We live for the early morning's in the stand, and the late night's gathered around a tailgate. The sound of crunching leaves is forever etched into our memory, and we often find ourselves day dreaming of an arrow perfectly hitting its mark. Our team is made up of some of the most diehard bowhunters, skilled machinist, and innovative engineers one could ask for - and when we set out to design the first REK broadhead, our goal was simple. We wanted to create a broadhead that worked flawlessly, and could be trusted by bowhunters far and wide. We understand the need for quality gear when at full draw, and recognize that failure isn't an option. REK Broadheads are designed and tested to perform. With the most advanced manufacturing processes and tightest tolerances in the industry we have created a broadhead that is simply better. REK Broadheads are built off of a universal modular design allowing one to change this broadhead from an expandable to a fixed blade by simply switching blades. Our expandable broadhead, the REK 1.8, introduces new Spring Lock Retention technology that holds blades securely closed while also aiding against accidental deployment. We pride ourselves in our premium American made quality, and you can rest assured that each and every broadhead has been individually inspected to meet our standards. Bowhunters across the country are making the switch to REK, and the results are speaking for themselves. Believe the hype.
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https://www.rekbroadheads.com/our-story
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14873235
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The unit's spacious and inviting foyer leads to an expansive great room extending over 35 feet, featuring fabulous western exposures, ceilings over 10', over-sized double-hung windows and 4" white oak floors throughout - all contributing to a wonderful open feel.
The open, eat-in kitchen is conveniently set back from the great room and its generous dining area, allowing for multiple dining and entertaining options, and features a large island with seating for 5, custom oak cabinetry and hardware from Italy, Calacatta Gold marble counter tops and is fully equipped with a Sub-Zero refrigerator and wine storage, Wolf gas range with a vented range hood, and Miele speed oven and dishwasher, as well as a garbage disposal.
The spacious master bedroom suite features a large finished walk-in closet, an adjacent windowed room suitable for a sitting room or nursery and a luxuriously finished master bath with radiant floor heating, polished Calacatta Gold marble floor and wall tiles, custom double vanity, fixtures and tub by Waterworks, and separate shower stall. Additionally, this grand space features a separate home office outfitted with finished closets, and full second bath with Waterworks fixtures. A multi-zone 4-pipe heating and cooling system and a full size washer and vented dryer complete this impressive and unique unit.
About the Building: Ralph Walker Tribeca is a full service building with a 24-hour doorman, concierge and valet parking made available to residents. In addition, the building boasts over 40,000 square feet of amenity space including a fitness center, an 82-foot heated lap pool, wading pool, billiards room, a club lounge with bar and dining room, four common outdoor spaces with sunrise and sunset terraces, children's play room, teen lounge, media lounge, wine tasting room, conference room with Wi-Fi throughout club level, private recreation space and bike storage. Surrounded by the best of Tribeca, Battery Park City, and within close proximity to Brookfield Place and the Westfield World Trade Center transportation hub and shopping mall.
Looking forward to showing you.
Building Features 33 Floors157 Units
$3,450,000 / $1,892 per ft²
Listed on Apr 23, 2020
101 Days on Market
Not updated in 62 days
1 Bed / 2.0 Baths / 1,823 ft²
Total Monthly expenses: $5,169
Maintenance: $2,500 / R.E. Taxes $2,669
Exclusively listed with: Halstead Property, LLC Source: RLS
Joseph William Corda
Unit listing history
|Date||Status||Amount||Listed by||Owner Name|
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pricing report for unit 13S
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https://www.urbandigs.com/building/100-barclay-street/13s/
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14873236
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The Soloist takes centre stage bathed in a very becoming hue of pink and always sees the world through rosé-tinted glasses. She’s destined to be in the spotlight and surrounded by adoring fans.
2019 Vintage DUE FOR RELEASE SOON!
“Intensely aromatic with an array of fruits including cranberry, raspberry, watermelon and strawberry, this dry Rosé has a fresh but gentle palate which lingers with hints of anise” Olly Masters (Winemaker)
The 2019 season was a typical Central Otago season in terms of heat but what was unusual was the high rainfall and a lack of the north-west spring winds. The heavier spring rains encouraged vigorous canopy development requiring vigilance to ensure short interval spray programs were maintained to prevent any disease. Conditions for flowering and fruit set were ideal for Misha’s Vineyard with a mild autumn with perfect weather to enable ripening. However it was a very mixed season across the region with vineyards impacted by a severe frost early in the season (13th October) where temperatures plummeted to -4⁰C and three days of late frosts (6-8th April), which saw many vineyards scramble to harvest fruit as canopies collapsed. This was certainly a year to be thankful for steep slopes and a frost-drained vineyard site. Growing Degree Days (GDDs) were 1149 and fruit for this wine was handpicked at 4.5 tonnes per hectare.
This style of Rosé is an ideal aperitif wine but also works well with antipasto, salads, light pasta dishes as well as raw or lightly cooked seafood. It matches a range of white meats and is the perfect partner for summer parties and BBQs.
|Region||Central Otago, New Zealand||Vineyard||Estate-grown, single vineyard|
|Sub-region||Bendigo – Single Vineyard||Variety/ Clones||114 (33%), 4 (32%) 6 (25%) 5 (10%)|
|Planting||2005/07, Altitude: 210 – 245m||Harvested||4 & 9 April 2019|
|Harvest Analysis||Brix: 22.8-24.6 / pH: 3.41-3.36 / TA: 6.0-6.8 g/l||Bottled||6 August 2019 (Stelvin closure)|
|Wine Analysis||Alc:13.5% / pH: 3.39 / TA: 6.0 g/l||Cellaring||1-3+ years|
|Residual Sugar||4.36 g/l||Style||Dry|
The whole bunch Pinot Noir fruit was all destemmed and crushed into picking bins for soaking to extract colour and flavour from the skins. The juice was left in contact with the skins for less than one day to avoid excess colour and tannin but show expressive fruit. The fruit was then pressed and the juice cold-settled to clarify. The subsequent juice has the vibrant colour from the Pinot Noir skins, but not the tannins that would be extracted if the ferment was carried out on the skins like a red wine. The clear juice was fermented in stainless steel, at low temperatures (15°C), to retain aromatics and provide a freshness to the wine. The resulting Rosé is a dry-style with plenty of varietal character and fruit purity.
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https://mishasvineyard.com/product/the-soloist-pinot-rose-2018/
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14873237
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Thank you for stopping by to see this incredibly delicious Blackened Salmon.
This Blackened Salmon Zucchini Pasta is hands down the best salmon you will ever try. It is also the easiest recipe you will ever make.
Salmon is so good for you!
Salmon is so good for you which is why I serve it often. I have always known that salmon was good for your brain but had no idea of the other benefits. It is not only good for your brain but your heart, hair, skin, cholesterol and so much more. Salmon is a fantastic source of Omega-3.
Blackened Salmon Zucchini Pasta Tastes Terrific
This Blackened Salmon Zucchini Pasta is one of my favorite ways to eat Salmon. It is so full of flavor from Paul Prudhomme’s Blacken Seasoning and Salmon seasoning. I can find these seasonings at my local Walmart. Hopefully, you will be able to find them too. I wish you could taste this salmon. It is spicy but not hot and tender and flaky with a little crispiness on top.
How easy is it to prepare this Blackened Salmon Zucchini Pasta?
I use Paul Prudhomme’s blackening seasoning and his salmon seasoning. I use a hot skillet with a little olive oil and butter. A lot of people cook their fish on low, but for this recipe, the skillet needs to be hot. It will sear the blackening seasonings. Place the skin side down into the hot skillet for about two to three minutes. After seasoning the top of the salmon, flip it over and cook three to four minutes. The skin side will be the top side at this point. Now, I peel the skin off the salmon. After peeling the skin off the salmon, add the blackening seasoning to the side of the salmon you took the skin off. Flip the salmon over and cook for two minutes. It truly takes less than ten minutes to prepare this blackened salmon.
Typically, I serve my Blackened Salmon over Pasta Alfredo but this time I decided to serve it over zucchini pasta. I found this very inexpensive vegetable pasta gadget and love it. You can read more about it and how easy it is to turn zucchini or squash into strings that resemble pasta. It is a much healthier than pasta and easy to substitute in most pasta recipes.
Blackened Salmon Zucchini Pasta
- Blackened Salmon
- Two pounds salmon
- Two tablespoons Paul Prudhomme's Blackened Redfish Magic - Make sure the Salmon is coated well on both sides.
- Two tablespoons Paul Prudhomme's Magic Salmon Seasoning
- And Two tablespoons Olive Oil
- Two tablespoons of butter
- Zucchini Pasta
- Three large zucchini
- BLACKENED SALMON
- First of all, Heat the skillet with the butter and olive oil over medium-high heat.
- The skillet needs to be really hot before adding the salmon.
- Place the skin side down into the hot skillet for about two to three minutes.
- After seasoning the top of the salmon, flip it over for three to four minutes.
- It will be ⅓ to ½ way done which you will be able to see on the side of the salmon.
- Next, I peel off the skin.
- After peeling the skin off, add the blackening seasoning to the top side of the salmon you took the skin off.
- Flip the salmon over and cook for two minutes.
- If you like leaving the skin on, season it before placing the skin down in the skillet.
- Cook each side three to four minutes.
- The time you cook the salmon will vary depending on how thick it is and how pink you like it.
- Remove the Salmon from the skillet.
- ZUCCHINI PASTA
- After making the zucchini pasta, add it to the same skillet you removed the salmon.
- Add 1/3 cup of chicken broth
- /4 cup of heavy cream to the skillet
- Next, scrap all the goodies from the pan.
- Add the zucchini pasta.
- Stir the pasta until thoroughly heated.
- Serve Blackened Salmon over the Zucchini Pasta.
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https://recipesforourdailybread.com/blackened-salmon-zucchini-pasta/
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http://mamaunabridged.com/2020/02/21/private-behind-the-scene/
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How to Do Spring in New York
Even though the first day of spring was officially several weeks ago, we are only now beginning to get real spring-like weather in New York. That’s fine by me. I hate the heat and like to keep as much distance between myself and summer as possible.
Spring is a great season to be in New York. The blanket of cold is lifted and the blanket of overheated humidity has yet to descend. The hum of outdoor social life returns and the parks become alive again.
I know that summer is coming and that it will be several months of sweltering misery, so let’s enjoy the spring while we have it here. Here are some ideas of how you can best enjoy the springtime in New York City:
Go to Coney Island before it gets crowded. Coney Island is a fun place to go and enjoy the amusements and atmosphere. It gets choked with people during the official summer season (though if you walk far enough along the boardwalk you can find your way away from the worst of the crowds. Ride the Cyclone, visit the freak show at the Coney Island Circus Side Show and visit its freak museum. Get a hot dog at the original Nathan’s. There’s even the New York Aquarium there.
Go bird watching in Inwood Hill Park. Inwood in northern Manhattan is one of the city’s great treasures of a neighborhood and central to that is Inwood Hill Park. Where else in Manhattan can you see eagles and hawks and get lost in the woods? Bird watchers get to see a lot of interesting birds in the park, and not just eagles and hawks. Eagles were hatched in the park years ago to increase their likelihood of returning as adults. Hawks are long-time residents of Inwood (and other city spots). So go and enjoy watching nature’s predation at its most beautiful.
Visit a botanical garden. The city’s largest botanical garden is in the Bronx near the Bronx Zoo, but did you know that Brooklyn, Queens and Staten Island all have their own botanical gardens also? Lots of abundant park land and plant life abound at the botanical gardens, plus they often have special exhibits.
Take a historic walking tour. No matter what your interests are, there is history in New York for you. Interested in learning about the American Revolution, gangsters, labor strikes, punk rock? There’s a walking tour for you. When you can walk past something and tell someone something interesting about it, that’s makes you a better traveling companion. You might learn something interesting and historic about spots you walk by every day.
Enjoy some free outdoor theater. There is free Shakespeare in many public parks throughout the city and it’s a shame not to take advantage of that. There is so much good theater, art and creativity to sample for free that you should never jones for your theater fix. The New York Public Theater, New York Classical Theatre and Hip to Hip Theater Company all do a great job bringing free theater to the people of New York.
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https://matthewsheahan.com/2015/04/18/how-to-do-spring-in-new-york/
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There are many reasons that push people to stick to trains in India. It is apparent that Indian railways keep people connected to each other. Whether day today office goers or the long journeys; you can find people traveling all over the place by trains.
Many people think that trains usually are too packed but even then people prefer to travel by train, why so? Well, there are reasons that can vary from passenger to passenger. Some of the common reasons are given below:
Trains are always within budget. No matter you are a poor individual belongs to a middle-class family or a rich fellow; you can always find a train that is within your budget. Even if you are six members in a family and your budget is not too sound; you can avail low budget trains like Garib Rath trains or similar ones. These are specifically run for the people who cannot afford to travel otherwise. The tickets for these trains are really nominal. Moreover, you can also find rich and high budgeted people too traveling by train. They do travel by train because there are luxurious and absolutely comfortable trains too like Rajdhani express and so on. These superfast and air-conditioned trains keep the rich people comfy during their rides.
Time and availability
In metro cities, you can easily find many trains running to a specific destination throughout the day. Whether you want to go at night, in the morning or noon, you can find a train going at that time. Moreover, the availability of trains is also there no matter what. But yes, if you are planning a trip during festivals or high seasons then you have to be proactive in your ticket booking. You have to book a ticket well in time. You can avail superfast trains that run effectively, efficiently and in the most prolific manner.
No issues of food
You can always get something or other to eat during your train journey. You can even make the most of Food Delivery at Train. You would be catered food right on your table if you wish. You can order food or eatables that you want to eat and it would be delivered to you at the next station. In this way, you would not have to starve during the journey. Moreover, you can find the sellers and vendors all the time in trains. Finally, trains do halt at different stations and hence you get the chance to eat something from outside.
When you travel with your friends or family by train, you get a great family time. It is like a joyful picnic. Of course, it might sound the thing of past but it is the reality of present for many families. They travel in groups and have a great time. They enjoy the journey in the most effective manner.
Thus, by now you might be convinced to a great extent that trains do live in hearts of people!
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https://blogaton.in/why-people-choose-trains-for-their-journeys-in-india/
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Has the development of fine lines, wrinkles, sun damage, or other skin flaws over the years changed the way you feel about your complexion? Are you searching for a revitalizing remedy for achieving youthful and glowing skin? Thankfully, there is now an innovative skin transforming treatment available with VirtueRF, With the benefits of microneedling and cosmetic technology, VirtueRF can have your complexion looking healthy and rejuvenated.
What is VirtueRF?
VirtueRF is the newest generation of radio frequency microneedling, with FDA-clearance for your safety. It is a minimally-invasive treatment that helps stimulate natural production of collagen. VirtueRF treats wrinkles, fine lines, for the face, neck, hands, and body. Offering a truly comfortable patient experience, it includes the use of a compounded numbing cream and a tandem first in market electro current post treatment mask to ensure an unprecedented recovery and absence of visible evidence that you had a treatment today. Results are immediate and improve as time passes, providing the best of both worlds.
- Targets Wrinkles & Fine Lines
- Aims to Tighten Skin
- Improves Skin Tone & Texture
- Immediate Results
- No Downtime
- Virtually Pain-Free
What to expect?
VirtueRF works by stimulating the natural production of collagen and results can be seen in as little as three to four treatments spaced four weeks apart to maximize results. It targets unwanted scars and wrinkles, while it simultaneously tightens the skin.
VirtueRF’s treatment experience is ended with an exclusive mask. This mask system soothes skin and eliminates redness. An enriching Mask infused with antioxidants, vitamins, moisturizing and anti-inflammatory properties is applied to the skin.
With virtually zero down time, our team of aesthetic experts, coupled with VirtureRF the most advanced RF Microneedling platform available, can transform your skin so you will enjoy ‘filter free’ and ‘make-up’ free photos in short.
If you are ready to hit the reverse button on your skin for an even, youthful, and healthy complexion, VirtueRF could be the solution for you. Reach out to the professionals here at Dr. Renée Moran Medical Aesthetics to learn more! Contact us today and schedule your consultation towards a youthful and vibrant complexion!
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https://drmoran.co/virtuerf/
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Details About Pointe West Country Club
Vero Beach, Florida
We are proud to be an Arnold Palmer Golf Managed Private Club because we run under the philosophy of Partnering with our members in order to help facilitate the fulfillment of the Members’ vision for their Club. This partnership is exampled by our enrollment process of “Membership by Invitation.” This means that every new Member who enrolls in any of our Clubs is sponsored by, and receives an invitation from, a Member of the Club. This is a prideful tradition and ensures all of our New Members are families that will enhance our Membership roster and the camaraderie of the Club. Although, we take great pride in the many amenities and services that our Clubs offer, our most valuable asset is our Members.
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https://golflifenavigators.com/composite/pointe-west-country-club/
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GET REGISTERED …
If you happen to be a taxpayer living in Laurens County, South Carolina, you might want to circle this Friday (August 4) on your calendar.
That’s the deadline for registering to vote in an increasingly contentious election over a $109 million borrowing bill for new school construction. This controversial measure – which would raise property taxes on residents by as much as $400 – is being pushed relentlessly by Laurens County School District 55 superintendent Stephen Peters and his allies.
We addressed this referendum earlier this month, but things have gotten downright crazy in the intervening weeks. Last week, for example, a local limited government activist who is opposed to the measure was reportedly picketed by referendum supports and accused of being a racist.
Apparently several opponents of the plans put forward by Peters – who is black – have found themselves slapped with “race cards” in recent weeks.
We’ll have more on that story momentarily …
In the meantime, we would encourage any of our readers in Laurens County who are not currently registered to vote – and who care about how their tax dollars are being spent – to take a moment and visit the county’s registration and elections office this week.
In-person applications are due on Friday, while applications sent by mail must be postmarked no later than Sunday, August 6.
For those of you keeping score at home, students in this particular school district averaged 1356 on the most recent SAT exam – well below the statewide average of 1446 for students at government-run schools. Meanwhile the district’s average ACT score of 16.8 also lagged behind the statewide government-run school average of 18.2.
Is a new $109 million high school going to fix that? Don’t bet on it …
Laurens’ referendum will be held on Tuesday, September 5. Absentee voting will begin on August 22.
WANNA SOUND OFF?
Got something you’d like to say in response to one of our stories? In addition to our always lively comments section (below), please feel free to submit your own guest column or letter to the editor via-email HERE or via our tip-line HERE …
Banner via iStock
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https://www.fitsnews.com/2017/07/31/registration-deadline-looms-for-laurens-county-referendum/
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At Civiltech, we understand that our ultimate clients are the communities affected by our projects. We strive to ensure that our work has a positive impact. We work to build client trust, and we look for opportunities to volunteer and give back. We encourage and support our team’s community outreach and volunteerism both as a firm and as individuals. We are proud of the robust community outreach activities in which our staff participated in 2019 both as a company and through individual efforts.
Civiltech continued a longstanding tradition of celebrating Take Your Child to Work Day (TYCWD) in April. This outreach effort requires dozens of volunteers to ensure that our grade-school age participants have a fun and meaningful day. The kids participate in engineering activities, such as egg catapults and Popsicle stick structures, as well as fun events such as piloting drones and enjoying a feature movie. We love TYCWD as it teaches the youngsters a little bit about engineering, but they also get to see how mom or dad spends their day.
In November, we made a donation to the Elk Grove Village Food Pantry. Our efforts provided over 300 items to the pantry. Also, we continued our holiday tradition of kicking off our staff holiday party by first packing boxes at the Schaumburg location of Feed My Starving Children. The Civiltech team, together with another group of volunteers, packed 306 boxes of food which represents 66,096 meals and feeds 181 children for a year!
While we participate in the FMSC program annually as a company, Civiltech employees often choose to volunteer on their own time with their own families, both locally and while traveling. This year, Civiltech’s Joe Emry, P.E. and his family packed meals at FMSC in Eagan, Minnesota while traveling over the holidays.
Civiltech strives to support college students in their educational journey and career exploration. As a company, we attend several collegiate career fairs throughout the year and strive to not only hire many summer interns, but ensure that their time at Civiltech provides a fun, rich, and worthwhile educational experience. In November, Civiltech participated in the 14th Annual ITE (Institute of Transportation Engineers) Student Day. Civiltech’s Anmol Shrivastava, P.E., PTOE serves as Illinois ITE’s Director of Student Affairs and was an active participant in the coordination and planning of the ITE Student Day. Our participation included having a booth at the event’s career fair and sponsoring the event’s luncheon. We then invited students to our Chicago office giving them the opportunity to visit a working civil engineering firm and ask questions to our staff about a career in civil engineering. In fact, one of those students was recently hired as a designer in our Chicago office!
Civiltech staff are often invited back to their alma maters to participate in events providing inspiration and insight. In April, Jen Hyman, P.E. returned to Purdue to participate in a panel discussion at Juniors Exploring Engineering at Purdue (JEEP). This event is geared towards young women in their junior year of high school, providing them the opportunity to learn more about an education and career in engineering.
Supporting students interested in learning about engineering is important to Civiltech, and we often host job shadowing days. A Civiltech job shadow day is packed full of interesting activities that expose students to the wide variety of professional services we offer and the variety of choices a transportation engineering degree can provide.
Our student outreach also extends to the classroom. In March, Shirley Choi, P.E.; Jen Hyman, P.E.; and Kyle Mishler, our Director of Operations, spent an afternoon at Hinsdale Central High School giving a presentation on career paths for women in the engineering field. The young women were very interested in how Shirley and Jen chose their engineering path and the colleges they attended. We are proud of all of the women engineers and technical staff at Civiltech. We appreciate the opportunity to provide role models and encourage young women to pursue a path in a STEM related profession.
Civiltech’s Environmental Scientist, Samantha Primer, volunteers every other Tuesday assisting grade school students at Ogden Elementary with reading. Her work is part of Working in the Schools (WITS), a program that pairs community volunteers with students and teachers within Chicago Public Schools to provide supplementary literacy programming for students that need extra time to work on their reading and comprehension skills. WITS is the largest activator of year-long corporate volunteer programming in Chicago Public Schools and provides various opportunities for volunteers to engage with students.
Volunteer Time Off
Civiltech staff individually volunteer in a wide range of activities throughout the year. Civiltech supports its staff’s efforts with a Volunteer Time Off (VTO) Program. Through this program we aim to collectively make a distinctive contribution to the communities in which we work, live, and play through the establishment of effective partnerships and programs that make the best use of the energies and skills of our employees. We believe this to be a benefit to the community and to our employees themselves.
In December, Civiltech’s Steve Pautsch, P.E., PTOE worked with the Northern Fox Valley Chapter of Habitat for Humanity utilizing VTO time. He will be working on this house more in the New Year and will have the opportunity to meet the family at the House Blessing in April. Steve did this work as part of Civiltech’s Volunteer Time Off Program.
Jim Woods, P.E., PTOE uses VTO time assisting with a breakfast and clean up shift at DuPage Pads, an interim overnight housing program. In addition to overnight housing, PADS provides support services to enable individuals to receive casement management, life coaching, and employment support.
We’re thrilled with all we were able to achieve in 2019 and the important contributions our staff made to our communities and the world at large. We look forward to expanding our programs, our opportunities, and our outreach throughout the New Year.
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https://civiltechinc.com/civiltech-strives-to-give-back/
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Simon Stanley searches for the best lunchtime bargains in District 1. Photos by Simon Stanley and Jonny Edbrooke.
If you’re chained to a desk or simply trying to save cash – or, in my case, both – making lunchtimes count can be a chore. Since the day my favourite bun cha wagon disappeared from outside our apartment building, my midday ritual has become a lacklustre cheese sandwich eaten at my desk over YouTube videos. Whether time or money is your enemy, I fear I am not alone in my solemn routine. Here are five affordable lunch options that beat watching cats do the ‘Thriller’ dance any day.
79/2/5 Phan Ke Binh, Dakao, D1
08 62 710 115 // Lunch Mon to Sat 12pm – 2.30pm
Decibel and its weekly movie screenings, open-mic nights and free food events may be the worst-kept secret in Dakao but its two lunchtime deals are news to the evening crowd. The VND 90,000 Western menu offers either a sandwich, a salad or a pasta dish with a soft drink thrown in, while the real bargain lies in their popular daily rotations of homemade Vietnamese cuisine, priced at VND 49,000. Poached pork in coconut juice and caramelised chicken with ginger are among the highlights but bun thit nuong cha gio is always on the menu. Order up and you’ll be presented with a giant bowl of noodles and beautifully grilled pork, fresh greens and piping hot spring rolls, a worthy rendition of the dish.
26 Ngo Thoi Nhiem, D3
08 39 300 233 // Set lunch Mon to Fri 11am – 3pm
With its killer margaritas, party-like atmosphere and some of the best Mexican food in town, you may well have promoted Khoi Thom to the ‘only for a special occasion’ list but its weekday lunch menu could change your mind. Thirteen dishes are available across three price levels, starting from VND 110,000. Freshly-made tacos are a highlight – the Baja-style fish quickly ranks among my top five meals in Saigon. Alternatively, opting for a plump burrito or torta will set you back VND 125,000 with a salad included. For the ravenous, four main-course favourites come in at VND140,000 each. At these knockdown prices you’re onto a winner already, but Khoi Thom also throws in free flow soft drinks, including homemade lemonade, and a choice of Mexican desserts or fresh fruit.
1st Floor, 77B Ham Nghi, D1
09 09 368 201 // Lunch Mon to Fri 11.30am – 1pm
Blending Parisian cafe stylings with old Saigon charm, La Rotonde could be one of the prettiest spots in the city. This cool, breezy loft space of whitewashed brick, tropical greenery and antique photography is the ideal place to lose yourself for a few hours. But visit during a weekday lunch hour, however, and things are a little livelier. With a buffet lunch on offer for VND 65,000, it’s not surprising that La Rotonde is packed to its extremely high rafters. In addition to ‘all you can eat’ salad, rice and vegetables, one main meal is included from a rotating list of up to eight, including shrimp in chilli sauce and a Chinese sausage omelette.
Robata Dining An
15C Le Thanh Ton, D1
08 38 225 329 // Lunch 11am – 2pm
In terms of quality, portion size and variety, Robata’s extensive lunch menu is one of the best deals you’ll find on Le Thanh Ton. With most dishes hovering around the VND 100,000 mark, this authentic Japanese open-kitchen diner serves everything you could think of, from a mixed tempura and rice (VND 90,000) to steaming bowls of pork ramen (VND 100,000). At VND 150,000, the beautiful 13-piece assorted sushi platter is a steal. Overflowing with generous morsels of freshly prepared seafood, everything on the platter is flown in each morning from Danang. A long wooden bar allows for a relaxed atmosphere, ideal for solo diners, while the private booths upstairs provide a more intimate experience.
Truong Dinh Lunch Lady
Corner of Truong Dinh & Vo Van Tan, D3
Lunch 11am – finished
Escape the air-conditioning and lunch al fresco like a local. Every weekday morning, two local ladies build a sprawling Vietnamese buffet restaurant right on the pavement of Truong Dinh. With a beaming smile, the proprietor offers a plate heaped with rice, inviting diners to construct their meal from a series of roughly 15 metal serving trays, each containing a separate dish. Several varieties of fish are lined up alongside potatoes, green beans, cabbage, mushrooms and grilled tofu, but it’s their speciality fried chicken that really makes this spot worth a visit. Meaty and flavoursome with a crisp skin and plenty of seasoning, it’s obvious why the tables are soon full and a line of hungry office workers has formed up the street. Plates start at VND 25,000, with each portion of meat or fish costing an additional VND10,000. Arrive early or it may all be gone.
Published March 2015 – AsiaLIFE Vietnam
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https://simonstanleywriter.com/2016/05/14/saigons-lunchtime-bargains/
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On Golden Pond quotes,On Golden Pond (1981)
Director: Mark Rydell,Stars: Katharine Hepburn, Henry Fonda, Jane Fonda
Ethel: Listen to me, mister. You're my knight in shining armor. Don't forget it. You're going to get back on that horse and I'm going to be right behind you, holding on tight and away we're going to go, go, go!
-Why not? You did it.
-Never mind. I'll explain later.
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http://imoviequotes.com/on-golden-pond-quoteson-golden-pond-1981.html
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|Total launches huge-capacity LNG bunker vessel|
|Ship to supply CMA CGM's ultra-large newbuild boxships as part of 3m-tonne agreement.
|Image credit: Total|
|Updated on 18 Oct 2019 13:04 GMT
|Total has announced the launch of its new LNG bunker vessel, which is due to begin operating in northern Europe next year.
The 18,600-cubic-metre-capacity ship trumps the capacity of the world's first purpose-built LNG bunkering vessel, Gas4Sea's Engie Zeebrugge, which operates in the north European port of Zeebrugge and has the capacity to hold up to 5,000 cubic metres (cbm).
It also beats the 7,500-cbm capacity of the Kairos gas supply vessel developed by Bernhard Schulte Shipmanagement (BSM) and Babcock International Group, which is chartered by LNG bunker supplier Nauticor and also operates in north Europe.
With this vessel, bunker arm Total Marine Fuels Global Solutions (TMFGS) intends to focus on supplying LNG to the container ship segment, including those sailing on the Europe-Asia trade. In particular, it is to be used to supply CMA CGM's newbuild LNG mega-container ships. TMFGS signed a 10-year, 300,000-tonne-per-annum supply contract with the boxship operator in December 2017.
The 135-metre-long vessel is described as being highly manoeuvrable, designed to operate safely in harbours and terminals, and built to meet the highest environmental standards through the use of LNG as fuel and a complete reliquefaction of the boil-off gas.
It is built by Hudong-Zhonghua Shipbuilding in China and fitted with the Mark III membrane containment system provided by French tank specialist GTT.
TMFGS signed a long-term contract with Mitsui O.S.K. Lines (MOL) to charter the ship in early 2018. The vessel is to be managed by MOL (Europe Africa) Ltd - a UK subsidiary of MOL.
"Developing infrastructure like this giant bunker vessel is essential to allow LNG to become a widely used marine fuel," said Momar Nguer, President for Total Marketing & Services.
"This first ship demonstrates our commitment to offering our customers both more environmentally friendly fuels and the associated logistics. Thanks to this pioneering investment, Total is making a positive contribution to the sustainable evolution of global shipping."
Total claims to be second-largest private global LNG player with LNG sales of 22m tonnes in 2018, an overall global portfolio of around 40m tonnes per year by 2020, and a global market share of 10 percent.
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https://bunkerindex.com/news/article.php?article_id=21402
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Livingston Eugene (Gene) Spyres, 94, of Williams, CA, passed away November 17, 2016.
Gene was born in Springdale, Arkansas, on January 31, 1922, to Oscar & Lola Spyres. His siblings are Richard “Dale Spyres (deceased); Max Spyres (deceased); and survived by Mary “Bernie” Kalfsbeek.
He was wedded to Freda Marie Bennett from Texas on February 2, 1946, in College City, CA.
Gene was a World War II Veteran (1942-1946) where he served in the United States Armed Air Forces in the “8th Air Force.” After the war, he was employed by the Ford Motor Company in Richmond, CA, and later transferred to the Ford Mtr. Milpitas, CA plant and retired in 1977.
He was a dedicated and loving husband/father. He enjoyed watching professional wrestling, baseball, and football and was our family’s champion “dominoes” player!
He was preceded in death by his wife Freda (1994) and his son David (2016). He is survived by daughter, Carolyn Estes, Midville, GA; daughter, Jean O’Brien, Williams, CA; son, Steve Spyres, and his wife, Darlene, Yuba City, CA. He was blessed with 11 grandchildren, 13 great grandchildren and 5 great great grandchildren.
A celebration of life will be held at McNary-Moore Funeral Service, Colusa, CA, on Wed. November 23 from 5:00-8:00PM.
In lieu of flowers, memorial contributions in Livingston’s name may be made to the Williams Fire Department, 810 E. Street, Williams, CA, 95987.
Arrangements are under the direction of McNary-Moore Funeral Service (530) 458-2111.
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https://williamspioneer.com/2016/news/80106/
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Prime dryer cords are constructed with vinyl to resist cracking, acids, oils and grease. Wire dryer cords fit most homes built after 1996 and each cord includes a strain relief kit.
Prime’s amp dryer cords have ring terminals for secure connections and molded-on plugs that won’t pull apart from the dryer cord.
Our amp dryer cords come in black or gray, in 3-wire or 4-wire, and in 4ft, 5ft or 6ft cord length to suit any laundry room. All Prime wire and cable cords are cULus or equivalent certified and come with a lifetime warranty.
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https://www.electriduct.com/Prime-Dryer-Cords.html
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Everton are reportedly lining up a January swoop for £10 million rated Bordeaux forward Diego Rolan.
The 22-year-old, who can play down the right or through the middle, scored 15 goals for the Ligue 1 side last season.
However, this term the Uruguay international has struggled, netting just once in 15 appearances.
But despite his dip in form, a number of clubs still have their eye on the attacker, with Everton strongly linked with a move.
Toffees boss Roberto Martinez is looking to add some competition to his forward ranks and is also wary that an injury to top scorer Romelu Lukaku would leave his side short of quality in the final third.
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https://www.shoot.co.uk/everton-target-10-million-forward/
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Thursday, 19 March 2009
Who's The Daddy?
Are we witnessing a power struggle at Barnet Council? Just over a week ago, Council Leader Mike Freer issued a public statement acknowledging that the public had not been told the truth about the £27.4 million invested in Iceland. Mr Freer said he had been misled by officers and promised an external investigation.
Today, new Chief Executive Nick Walkley told the Barnet Press that he was launching an internal investigation.
Well, which is it to be?
Are we to have a fully independent external investigation that will examine in detail every document and interview every person who was involved in devising and implementing the council’s treasury management strategy, that will leave no stone unturned so that we can get to the truth? Or are we going to have an internal review under the auspices of the officer who was Executive Director for Resources at the time the money was deposited?
For the sake of Barnet’s taxpayers, let us hope that that Mr Walkley does not get his way.
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http://www.notthebarnettimes.co.uk/2009/03/whos-daddy.html
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Mobile advertising and discovery platform, InMobi, has just released some data that shows its remarketing platform, powered by Miip, is driving up eCommerce sales by 7%. Miip is InMobi’s digital curator and discovery platform launched last year.
The company says that the average consumer purchases products worth around Rs.1500 to Rs.2500 through the platform, which translates to a return of $8-$10 for every ad dollar spent. Prominent eCommerce retailers such as India’s Myntra and PayTM and China’s Nuomi have since started using the platform.
InMobi Miip drives eCommerce sales by 7%
The platform packs a combination of data analytics, creative design and back-end integrations to drive a more individualised shopping experience on mobile apps. In addition, advertisers can tap into the remarketing features to nudge users to make their first purchase or re-engage existing customers.
InMobi says that the solution also extends to on-demand services, travel, news and entertainment apps to increase engagement and revenues.
With smartphone users spending just 5% of their time on shopping apps, and 57% checking them only monthly, according to Forrester, the remarketing solution can help to reach users even when their being spotted on other mobile apps. InMobi’s SDK is directly integrated with over 30,000 mobile apps.
When a user clicks on an adverts, s/he is deep linked to the app’s product detail page for a seamless buying experience.
Ananth Narayanan, Chief Executive Officer, Myntra, says:
“We have seen a real improvement in our re-marketing campaigns since leveraging InMobi’s re-marketing platform powered by Miip. Miip is an ingenious platform which can grow m-commerce rapidly in India.”
In partnership with eCommerce companies and a deep back-end integration between them, InMobi is able to let sellers create audience segments in real-time and target them instantly across 3rd party apps with custom offers. The company’s network now extends to 135m users in India and over 1,000 publishers.
Naveen Tewari, Co-founder & CEO, InMobi, adds:
“Indian eCommerce is at a tipping point, and Miip is poised to play a critical role in enabling this ecosystem. Advertisers can now extend beyond driving brand awareness and app installs, to increasing sales and transactions through mobile advertising. We’re still in the early days of mobile commerce in India, as these numbers continue to rise, users will be able to discover and buy products that they need, but didn’t know existed.”
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https://www.businessofapps.com/news/inmobi-discovery-platform-miip-helps-to-drive-ecommerce-sales-by-7/
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Maddie, who you may know if you’ve visited the store, says I have a chalkboard problem. I think this project may confirm her theory!!
We purchased a dresser and the mirror was unattached and missing a mirror. I’m not a huge fan of mirrors on the backs of dressers (hang them on the wall!) so we decided to make this one a chalkboard.
Here’s where we started:
Maddie painted a coat of Miss Mustard Seeds Milk Paint in typewriter on the writing surface:
We chose another favorite color, kitchen scale, for the frame:
Then we seasoned by rubbing chalk on the writing surface:
And here it is:
Now, aren’t you a little obsessed too??
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https://www.fivethirtyhome.com/blog/news/the-chalkboard-obsession-continues/
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Featured Illustration – ‘The Classroom’ by Sue deGennaro
Our fifth feature from our Books Illustrated exhibition is The Classroom by Sue deGennaro, from ‘Max & George’ by Cori Brooke.
The first thing that strikes you in this, and all the illustrations, from ‘Max & George’, is how Sue deGennaro has used grid paper as the background for many of the elements in the artworks. The combination of the conte (which is like hard pastel) and gouache (a more opaque style of watercolour) creates simple but striking colours that lift all the pictures depicting Max, a small boy about to start school, and George, his imaginary friend that appears as his reflection.
This is a charming and quietly funny story about a young boy making a big change in his life and adapting to it. It’s also a great example of how the illustrator adds so many different layers to the original story; for example, nowhere does Cori Brooke specify in the text that Max’s reflection appears as a rabbit, but that is how Sue deGennaro has interpreted it. This makes the reader feel like they share a special secret with Max.
If you’d like to see The Classroom in all its lovely detail, and all our other Books Illustrated prints for this semester, please stop past the Front Office. And if you’d like to order a print for yourself or a loved one, please complete our order form and return it to the Front Office.
(If you missed last week’s feature, check out Orongobong Orangutan by David Miller)
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https://cms.act.edu.au/the-classroom-sue-degennaro/
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Poppy lives near Tokyo and likes to read novels and play video games, especially fantasy RPGs. Dragon Age: Inquisition is a standout title of the fantastic fantasy role-playing video game series by BioWare. Aside from epic side quests, an awesome storyline, and warrior classes , there is a great assortment of romanceable characters for you to choose from. Romancing is optional, but it is a great and immersive addition to the game. Depending on your character's gender and race, there are different ways for your character to woo someone. Just follow some simple steps! But who to choose?
Travel there, and you'll be in a small courtyard at night. You'll have a very easy fight. Keep exploring to find a door, which leads to an inner plaza.
After a cut scene, you'll have one more fight, and it'll be easy. Afterward, you're given the choice whether to recruit a new party member, Sera, to your cause.
Either way, it resolves the quest. Those looking to romance Sera should know that you'll never really be able to bring Sera to your level - she does things on her own terms and nobody elses.
Romance with Sera in Dragon Age Inquisition Dragon Age: Inquisition Guide. 0. Post Comment. Next Romances Solas Prev Romances Cassandra. Sera. Who may enter a love relationship with Sera? You can romance with Sera only if you play as a female, regardless of your race. This means that the relationship is going to be a homosexual one.
This can lead to confusing conversations, but have patience and do her personal quests to gain approval. You can also check out her codex for added info over time, as well as a journal she keeps in the Skyhold Tavern.
Mark Walden Dating Coach, Free Online Dating In Jardines de la Silla (Jardines) (Mexico, Nuevo Leon), Dating Ring New York Times Online Dating Santa Cruz de Tenerife (Spain, Canary Islands) Best Dating Websites In Pakistan Dating Sera Dragon Age Free Online Dating In Kutloanong (South Africa, Orange Free State) Best Quick Hookup App. How Romance Works in Dragon Age. Do you like this video? For the romances in the specific games, see Romance (Origins), Romance (Dragon Age II), and Romance (Inquisition). For sexuality in Thedas, see Sexuality and marriage. Romances have been a recurring ct of the Dragon Age game series. In Dragon Age: Origins, four companions are romantic. Dec 01, Sera is impulsive and revels in the moment. For her, it's not about what's right, it's about what's right now. In the Friends of Red Jenny, she humbled authority and had fun doing it.
Be warned that Sera will not accept what happens in Mythal. If you should be determined to believe in what transpired, your romance with Sera will end. Assuming her disposition is high enough, this will be triggered when you speak to her and tell her that you are interested in her.
To get her disposition high, you'll generally need to look for the strongest punishments for any Sit in Judgment quests, and favor killing or otherwise punishing those who wrong you. Sera enjoys pranks, and tends to be atheistic, so you should publicly doubt the view that you are actually Andraste's herald. If Sera is receptive, after a couple more chats with her, she'll tell you she bought you a hat.
Your character is concerned that she needs to buy a return gift for Sera, which actually triggers the quest. To resolve it, you simply need to talk to each of your companions in any order. Speak to Sera again after that, and you'll get a payoff cut scene, as well as officially be in a relationship after that.
So ok about marriage in trespasser why is it only for Cullen and Sera. Did bio ware ran out of time to do every character or what. Will they ate it so . Jun 07, The Complete Romance for Cassandra from Dragon Age Inquisition. Skip navigation Dragon Age Inquisition - Cassandra Complete Romance Revan Dragon Age Inquisition - Sera Complete Romance. Despite threats to boycott and general shock from certain countries, Dragon Age: Inquisition provided us with a fresh batch of gay and pansexual characters. Sera, for example, is a lesbian and is only possible to romance if your character is female. *Note, you can romance Sera as any race, but she especially loves Qunari and Dwarf women.
If you ever want to break up with her, speak to her and make your feelings known. However, as with all relationships, if you break it off, there's no going back. Last Edited: 1 Dec pm.
Recruiting [ edit ] A Friend of Red Jenny is triggered as you walk away from the first major cut scene in Val Royeaux. I look forward to hearing from you. Licensed Clinical Professional Counselor.
Dragon Age Inquisition: Complete Sera/Dwarf Romance, aka. Twee Romance
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http://fireemblemheroestips.com/dating/dating-sera-dragon-age.php
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Fun for Kids
If you are visiting Wiltshire and the South West with family you won’t be short of fun packed activities to fill your day. We’ve picked out some attractions below that we think are really super fun for kids, but there are other attractions in the area which also make for great family days out. Don’t miss out on the great selection of historic attractions, museums, and great houses all on your doorstep - what better what to explore our country’s fascinating past!
If you and your family love animals why not visit the UKs number one safari park - Longleat Safari and Adventure Park - for an unforgettable day out and great fun for kids. Alternatively the Hawks Conservancy Trust is a gem of a place. Conveniently located just off the A303 it has a great collection of birds of prey, and is an award winning centre working in the fields of conservation, education, rehabilitation and the research of birds of prey.
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http://hisalisbury-stonehenge.co.uk/local-attractions/fun-for-kids
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By the end of this year, crop sprayers sold in Australia by agricultural equipment manufacturer Agrifac will incorporate smart weed detection technology from French start-up Bilberry.
Bilberry’s technology will enable farmers to determine, in real time, whether particular crops need weedkiller or not. Its cameras can be mounted on the arms of any make or model of crop sprayer. Meanwhile, an on-board computer recognises weeds from real-time images crops and controls the flow of herbicide via the sprayer.
All information collected ‘in the field’, regarding the presence of weeds and the application of herbicide, is made available to farmers in the form of maps. The goal is to massively reduce the amount of weedkiller needed – potentially by up to 80 percent, Bilberry claims.
This is the first commercial application to emerge from the Smart IoT Application Development (SIOTAD) framework launched in February this year by EIT Digital, part of EU R&D agency EIT (European Institute of Technology).
Farmers down under
As well as the reduction of weedkiller usage, there’s a water conservation aspect to this, too, as Bilberry CEO Guillaume Jourdain has pointed out: “Fighting weeds is a priority for Australian farmers, as these unwanted plants consume the resources of any already dry soil.”
This year, the Australian national winter crop harvest is expected to be 40 percent smaller than last year, according to a report issued last week by the Australian Bureau of Agricultural and Resource Economics and Sciences, thanks to drought, high temperatures and a late start to the winter season.
The Bilberry weed detection feature will be marketed to Australian customers as an option on top of the standard Agrifac products – mostly crop sprayers and sugar beet harvesting equipment. Agrifac is headquarters in Steenwijk in the Netherlands and, since 2012, has been part of Groupe Excel Industries, a global spraying giant with revenues of €819 million in its 2016 fiscal year.
Agrifac’s Australian subsidiary, however, was only established in 2014, so is a bit of a start-up itself.
Change of strategy
The deal between Agrifac and Bilberry marks a change of strategy for Bilberry. Jourdain originally intended to sell directly to farmers – but he’s since recognised, he says, that Agrifac’s sales network will help it to reach more customers in less time. By the end of 2018, he reckons, more than 10,000 hectares of Australian land will have been scanned with Bilberry’s technology.
This was originally developed in collaboration with Nokia, which provided the live development and trial environment (Nokia Innovation Platform) that Bilberry used to access the massive computational power needed to train its algorithms.
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https://internetofbusiness.com/agrifac-bilberry-weeds-aussie-farms/
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SAN ANTONIO — San Antonio has a thriving arts community, thanks in part to a constant flow of energy from young artists with new ideas and fresh approaches. Here's a look at five to watch: Adriana Corral, Jenelle Esparza, Mark Menjivar, Fernando Andrade and Jessica Sailors.
On a trip to her hometown of El Paso, Adriana Corral walked along the border fence that separates the United States from Mexico, collecting some of the sun-beaten soil for an installation dealing with the killings of women in neighboring Juarez.
Over the past four years, she has returned to the story of those women again and again, creating quiet, meditative works that somehow speak volumes.
“I think I became really sensitive to it, especially being in such close proximity to it, and then it felt like this responsibility,” said Corral, 31, who graduated from the University of Texas at Austin with a master's degree in art in 2013.
For “Voces de las Perdidas” (“Voices of the Lost”), a 2010 installation, Corral strung hundreds of ceramic body tags from a gallery ceiling. More recently, an exhibit at Cinnabar Gallery included an acetone rubbing Corral created with documents she obtained from human rights attorney Ariel Dulitzky, who sued the Mexican state of Chihuahua for not properly investigating the killings of eight women found buried in a cotton field in 2001. A similar work was made up entirely of the women's names, painstakingly applied in multiple layers to create a block of visual static.
For an exhibit coming up at Artpace in September, Corral, who shares a near West Side studio with fiancé and fellow artist Vincent Valdez, plans to apply text directly to a gallery wall and create a pair of graves on the floor — one of soil, one of ashes.
“The process is almost equally important for me (as the completed work),” she said. “When I put text up it's almost like the invisible work you don't get to see.”
Amada Cruz, executive director of Artpace, describes Corral's work as “brave, in that she's not afraid to confront difficult subject matter.”
“I also appreciate how well-researched her work is,” Cruz said. “The elegance of her forms draws you in, and then you encounter the very serious content — super smart but emotional too.”
When Jenelle Esparza was working on “Ancestral Archetypes,” a series of “shadow portraits” of women, she tried different light sources to create silhouetted images of her subjects.
“The window ended up being the best thing every time,” she said.
It's also an apt metaphor for the photographs — black-and-white double exposures that provide an intimate glimpse into the women's lives.
“I wanted to take these portraits that would tell you a little bit more about this person without showing you their face, like maybe something under the surface,” said Esparza, 28.
Esparza created the photographs in “Ancestral Archetypes” by pairing images of the gardens, plants and natural surroundings around her subjects' homes with their silhouetted images. One of the women had begun writing poetry after her husband's death.
“When the resulting image came out, these blooms were just like coming from her lips — just really beautiful,” she said.
From Corpus Christi, Esparza received a bachelor's degree in photography from the University of Texas at San Antonio in 2010. In addition to her photography, she also creates multimedia installation and abstract photo-based pieces. Her résumé includes a growing list of exhibitions, including solo shows at REM Gallery and the Blue Star Contemporary Art Museum, where “Ancestral Archetypes” is on view.
“I think one thing that's most exciting for me about her work is the way that she's used traditional processes in going with film photography but has layered the images and is taking on contemporary ideas using older techniques,” said Mary Heathcott, executive director of the Blue Star.
When Esparza does freelance work, she opts for the precision of digital imagery, but for her artwork she prefers to take her chances with film, where accidents — both happy and not — are always a possibility.
“That's one thing I think I really enjoy about using film and especially when I'm using it with multiple exposures, because that organic element is out of your control,” she said.
“Ancestral Archetypes” continues through Aug. 3 at the Blue Star Contemporary Art Museum,116 Blue Star, www.bluestarart.org.
Mark Menjivar did not come to art by any of the traditional routes.
Instead, he studied social work at Baylor University. After graduation, he spent two years in Bolivia working with street kids and women involved in prostitution. Burned out by the experience, Menjivar returned to the United States in 2005.
“That's when I first picked up a camera and started taking photographs,” said the 34-year-old, who recently earned a master's degree in art and social practice from Portland State University.
Though now a freelance photographer and artist, his background continues to inform his work.
“I'm always looking at not just individuals, but at society and how communities come together and asking where meaning is located in what we do,” he said. “My practice is such that some people may look at me and say, 'Gosh, well, he's a journalist or a sociologist or an anthropologist' and I actually like that. I like having that mixture of things in there.”
Some of his projects include “You Are What You Eat,” a series of portraits depicting the contents of refrigerators in homes across the country; and “My Sadness Goes On and On,” an ongoing list of sad songs submitted by people around the world.
Currently, Menjivar is working on a book about “The Luck Archive,” a collection of personal narratives and objects related to the concept of luck. He began the project about three years ago, inspired by four four-leaf clovers he found pressed between the pages of a used book. He gives each person who contributes a photographic print of one of the clovers.
“So often when we think about the art world, we think about the traditional gallery system where you put something on the wall and it's for sale,” Menjivar said. “But in a lot of my projects, I'm really not selling anything. I'm giving things away to people as a thank you or as an exchange.”
“The Luck Archive” was part of an exhibit of interactive art curated by Leslie Moody Castro for Contemporary Art Month.
“Mark Menjivar is pure effervescence,” said Castro, an independent curator who lives in Austin and Mexico City. “His work is honest and thoughtful, and instigates a moment in which people can really connect.”
In Fernando Andrade's latest graphite drawings, two young boys gleefully drag a garbage bag bulging with body parts, while another boy, with a sort of malicious grin on his face, stirs acid in a barrel that has an arm hanging over the side.
Powerful, disturbing images executed in a hyper-realist style, the drawings are from the 27-year-old San Antonio artist's “Tierra y Libertad/Land and Liberty” series, inspired by his early years growing up in Ciudad Acuña, in northern Mexico — and the subsequent deterioration of the border region into a war zone.
“They come from my memories of playing as a kid, playing cops and robbers, tag, soccer in the dirt road,” Andrade, who came to San Antonio at age 7 with his family, said during a recent tour of his studio at Hausmann Millworks. “What kids are going through now is death, violence, weapons, the military. The games they are playing are a little more serious.”
With the recent influx of young immigrants from Central America, Andrade's drawings have special meaning and relevance. He will show new work at the Blue Star Contemporary Art Museum in December.
“He is a wonderful artist,” said Blue Star Director Mary Heathcott. “In addition to being a technically talented artist, Fernando's work deals with contemporary issues in interesting ways — child's play as a point of investigation of U.S./Mexico border violence, for example. He has this keen approach to his subject matter and composition.”
By contrast, Andrade's paintings are abstract riots of color and pattern, influenced by Gustav Klimt, the Austrian symbolist painter, as well as by Andrade's experience as a muralist in the Jefferson area. While the drawings reflect the world and have a hard-hitting message, the paintings are simple personal expression.
“They reflect my spiritual side,” said Andrade, a Jefferson High School graduate who earned an associate's degree in graphic design from San Antonio College. “I just let it flow. It's you and the paint. Have fun.”
Jessica Sailors is young and thin, with a radiant smile and her hair in a thick red braid. She could be one of those models exuding good health from a grocery-counter magazine cover.
“But I still struggle with body image,” said Sailors, a 27-year-old Bastrop native who recently earned her master's of fine arts degree in ceramics from the University of Texas at San Antonio and now is teaching at the school. “When I get out of the shower in the morning, it's hard for me not to look at myself in the mirror and see crow's feet and love handles. 'Oh, my butt's dropping, better do more squats.'”
Body image is at the core of Sailors' ceramic work. Her most recent pieces resemble women's body parts formed together into what she refers to as “these intimate little objects.” She calls some of them “Fleshy Bits.”
“I'm interested in cultural perspectives of beauty and the way we treat women's bodies,” Sailors said.
Last year, Sailors' work was part of the Kinsey Institute Juried Art Show at Indiana University, and she also has exhibited at the San Angelo Museum of Fine Arts.
“I have loved her work for years,” said local ceramics artist Wesley Harvey. “She was actually an undergraduate student of mine at Texas Tech University, and I knew at that moment that she was going to be a great artist. I love the sexuality of her work, but I like the ambiguity also. There is a kind of grotesque beauty with her work that I think is very nice.”
Why, Sailors asks, are fat deposits on women's chests glorified, yet fat deposits elsewhere on the body demonized?
She realizes men have body issues as well, but said there seems to be more pressure on women to live the ideal.
“And it's women doing it to each other,” she said. “Someone said a man will punch another man in the face and that will be the end of it. But a woman will give another woman an eating disorder.”
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https://www.expressnews.com/entertainment/arts-culture/article/Five-San-Antonio-artists-to-watch-5617566.php
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last nite (technically it was 1 am this morning).
It’s soooooooo cute, if I do say so myself:
Here are both girls in their hats:
I have printed off the first of the squares for project 6year! It’ll be for January.
I’m going to add the squares to my progress bar on the right side.
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https://www.cenla.net/i-finished-my-youngest-daughters-hat
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https://www.ymaspace.com/video+speed+controller+f%C3%83%C2%BCr+google+chrome.html
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The 5-Second Trick For Tallahassee housing market
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COVID-19 containment, and economic resilience are critical factors driving regional dissimilarities inside the housing Restoration. Per our before investigation, the unfold of COVID-19 is intently connected to the housing slowdown, with markets with larger circumstances for every capita much more very likely to see a bigger effect on provide along with the pace of sales.
We are an institutional real estate manager offering acquisition, asset management, portfolio administration, exploration, valuation and residence revenue skills for its purchasers. As knowledgeable fiduciary, we've been experienced in selecting, underwriting, obtaining and handling Qualities different in size from USD 10 million to more than USD 500 million.
Numerous brokers don’t take the time to know their market. Whenever you put effort and time into entirely comprehension your real estate market, you quickly attain a aggressive benefit. The more you know, the higher you can provide your clients and guidebook them towards producing the very best decisions.
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http://shaneylzmz.mybjjblog.com/the-5-second-trick-for-tallahassee-housing-market-10960594
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Polyakov is an Associate Research Professor at the NJIT Department of Computer Science & Cybersecurity Research Center. He is also a Principal Scientist at Duality Technologies Inc. His primary research interests are applied lattice-based cryptography, homomorphic encryption, and program obfuscation. He is a co-founder and core contributor to the open-source PALISADE Lattice Cryptography Library. Prior to joining NJIT, he worked as a research scientist at MIT CSAIL and held several senior-level industrial positions. His prior research dealt with time series analysis using statistical physics methods and mathematical modeling of membrane technology processes. He is a recipient of Moscow Mayor's Young Scientist Award (2005) and member of a winning team at the iDASH 2018 competition.
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https://qa-cd.rsaconference.com/experts/yuriy-polyakov
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Single Luggage Tag with slot and clear pocket with address panel insert on reverse. Printed FULL Colour. Supplied individually bagged with vinyl loop strap.
59mm (High) x 110mm (Wide)
A basic shape 2D luggage tag with logo printed onto one sideSize102mm (Length) x 70mm (Wide) x 5mm (Thick)
A custom shape 2D luggage tag with logo molded onto one sideSize(Approx measurements) 105mm (Lenth) x 65mm (Wide) x 5mm (Thick)
Plastic Key Tags with hole punched. Printed and supplied 3 UP. They can be printed front and back with full colour edge to edge.Tags only available in White.Size28mm (High) x 54mm (Wide)
Credit card size single plastic tag with full colour edge to edge print. Price below is for a generic full colour print one side and standard blank address panel template on reverse with 1 central slot. Option to personalise by adding name details or full colour print both sides. Attachments available, Imitation Leather Strap, Vinyl Loop Strap, 14cm Cord Loop & Metal Loop. See Accessories and add them to your cost.SizeNot Specified
Credit card sized plastic luggage tags with full colour edge to edge print on a thick 1.0mm durable plastic to help prevent breakage. Attachments available, Imitation Leather Strap, Vinyl Loop Strap, 14cm Cord Loop & Metal Loop. See AccessoriesSize85.4mm W x 54mm H x 1.0mm Thick
High quality silicon key tag perfect for branding. Printed or embossed option Manufactured from high quality flexible silicon to order PMS colour match available.
230mm (Length) x 25mm (Wide)
FREE CALL 1300 1 444 88
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https://www.4branding.com.au/products/bags/luggage_tags/56323-Luggage_Tag_Hard_Plastic_with_pull_out_insert
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TERMS & CONDITIONS
TERMS & CONDITIONS FOR DUBAI AIRPORT FREE ZONE
Acceptance of Terms & Conditions.Your use of the Dubai Airport Freezone website is governed by these Terms & Conditions. By using the website, you (the “User”) accept and agree to be bound by these Terms & Conditions. These Terms & Conditions represent a binding contract between Dubai Airport Freezone and you. Please read these Terms & Conditions carefully. If you do not agree with these Terms & Conditions, do not use the Dubai Airport Freezone website. The terms (“You”) and (“User”) as used herein refer to all individuals and/or entities accessing the website for any reason.
Use of websiteThe contents of this website including, but not limited to, the text, graphics, images, links and sounds are the property of Dubai Airport Freezone and are protected by copyright. Dubai Airport Freezone reserves all copyright, trademark, patent, intellectual and other property rights in the information contained in this site.
Use of websiteUsers are prohibited from violating or attempting to violate the security of the website, including, without limitation:
- Accessing data not intended for such user or logging into a server or account which the user is not authorized to access.
- Attempting to probe, scan or test the vulnerability of a system or network or to breach security or authentication measures without proper authorization.
- Attempting to interfere with service to any user, host or network, including, without limitation, via means of submitting a virus to the website, overloading, flooding, spamming, mail bombing or crashing.
- Sending unsolicited e-mail, including promotions, and/or advertising of products or services.
- Forging any TCP/IP packet header or any part of the header information in any e-mail or news group posting.
- Violation of system or network security may result in civil or criminal liability. Dubai Airport Freezone will investigate occurrences which may involve such violations and may involve, and cooperate with, law enforcement authorities in prosecuting users who are involved in such violations.
Tas’heel registration and passwordUsers of our Tas’heel e-service are required to register before using the Dubai Airport Freezone Website. When you register you agree to provide true, accurate, current and complete information about yourself as prompted by the Dubai Airport Freezone registration form made available to you via the website (such information being the “registration data”). You also agree to maintain and promptly update the registration data to keep it true, accurate, current and complete. If you provide any information that is untrue, inaccurate, not current or incomplete, or Dubai Airport Freezone has reasonable grounds to suspect that such information is untrue, inaccurate, not current or incomplete, Dubai Airport Freezone has the right to suspend or terminate your account and refuse any and/or all current or future use of the services provided in the Dubai Airport Freezone website (the “Services”). Dubai Airport Freezone reserves the right to reject registrations from companies without having to justify such rejection. Upon completing the registration process, You will receive a password. You are responsible for maintaining the confidentiality of your password and are fully responsible for all activities that occur under your password, including, but not limited to, applying for services against which you will be charged for a certain fee as fixed by Dubai Airport Freezone, regardless of whether or not such activities are authorized by you. You agree to immediately notify Dubai Airport Freezone of any unauthorized use of your password. Dubai Airport Freezone will not be liable for any loss or damage arising from an unauthorized use of your password
Prohibited usesAs a condition of your use of the services provided on the Dubai Airport Free Zone website, you warrant that you will not use (or plan, encourage or help others to use) the website for any purpose or in any manner that is unlawful or prohibited by these Terms & Conditions and the applicable law and that you will not: Upload, post, e-mail or otherwise transmit any content that you do not have a right to transmit under any law or under contractual or fiduciary relationships (such as inside information, proprietary and confidential information learnt or disclosed as part of employment relationships or under non disclosure agreements).
- Post any incomplete, false or inaccurate information.
- Use any device, software or routine to interfere or attempt to interfere with the proper working of the website or any activity being conducted on this site.
- Take any action which imposes an unreasonable or a disproportionately large load on the website’s infrastructure.
- Allow access to a non-public area of the website, disclose to or share your password with any third parties or use your password for any unauthorized purpose.
- Notwithstanding anything to the contrary contained herein, use or attempting to use any engine, software, tool, agent or other device or mechanism (including without limitation browsers, spiders, robots, avatars or intelligent agents) to navigate or search the website other than the search engine and search agents available from Dubai Airport Freezone on the website and other than generally available third party web browsers (e.g. Netscape Navigator, Microsoft Explorer, Safari).
- Attempt to decipher, decompile, disassemble or reverse engineer any of the software comprising or in any way making up a part of the website.
- Upload, post, e-mail or otherwise transmit any material that contains software viruses or any other computer code, files or programs designed to interrupt, destroy or limit the functionality of any computer software or hardware or telecommunication equipment.
- Collect or store personal data about other users.
- Transmit, post, distribute or store any message, information, data, text, software or images or other materials (“Content”) that is unlawful, harmful, threatening, abusive, harassing, tortuous, defamatory, vulgar, obscene, sexually explicit, libelous, hateful, racially, ethnically or otherwise objectionable to another user or any other person or entity.
- Post or transmit any content that contains viruses or corrupted data, Trojan horses, worms, time bombs, cancel bots or other computer programming routines or engines that are intended to damage, detrimentally interfere with, surreptitiously intercept or expropriate any system, data or information.
- Use the website’s communication features in a manner that adversely affects the availability of its resources to other users (e.g. excessive shouting, use of all caps, or flooding continuous posting or repetitive texts).
- Upload, transmit or post any content or use the website in any manner that infringes any patent, trademark, trade secret, copyright or other proprietary rights of any party or violate the privacy, publicity or other personal rights of any third parties.
- Make any unauthorized use of the website.
- Violate any applicable local, national or international law or regulation.
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https://www.dafz.ae/en/terms-and-conditions/
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Yahoo's huge data breach is making waves on Capitol Hill.
Continue Reading Below
Sen. Mark Warner on Monday asked the Securities and Exchange Commission to investigate whether Yahoo fulfilled its obligations to properly keep its users and investors abreast of its investigation into a massive data breach that saw 500 million user account details stolen.
"Data security increasingly represents an issue of vital importance to management, customers, and shareholders, with major corporate liability, business continuity, and governance implications," the Virginia Democrat, who serves on the Senate Intelligence and Banking Committees and is the co-founder of the Senate Cybersecurity Caucus, said in a statement. "Yahoo's September filing asserting lack of knowledge of security incidents involving its IT systems creates serious concerns about truthfulness in representations to the public. The public ought to know what senior executives at Yahoo knew of the breach, and when they knew it."
Yahoo announced last week that at least 500 million user accounts were hacked by what it believes was a government actor. While Yahoo said that its investigation is ongoing, it revealed that the data was taken in 2014. Since then, press reports have surfaced, saying that Yahoo CEO Marissa Mayer knew about the hack in July but did not notify users until last week. Verizon, which acquired Yahoo this summer, also wasn't notified until last week, the Financial Times says.
Federal law dictates that companies must inform users and investors of a breach within four days.
"I encourage you to investigate whether Yahoo and its senior executives fulfilled their obligations to keep investors and the public informed, and whether the company made complete and accurate representations about the security of its IT systems," Warner wrote to the SEC. "Additionally, since published reports indicate fewer than 100 of approximately 9,000 publicly listed companies have reported a material data breach since 2010, I encourage you to evaluate the adequacy of current SEC thresholds for disclosing events of this nature."
Neither Yahoo nor the SEC immediately responded to PCMag's request for comment.
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https://www.foxbusiness.com/features/senator-to-sec-you-need-to-investigate-yahoo-breach
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Dr Raewyn Teirney has been working in Gynaecology and Infertility for more than 15 years.
Welcome to Sex Therapy Sydney, Australia.
Raewyn is renowned for her caring approach and the time she spends with patients to discuss all options. Raewyn is determined to empower women and couples surrgoacy their fertility journey recognising the sense of frustration many experience in trying to start a family. Raewyn practices all aspects of infertility, however her special research and clinical interest in PCOS is paramount, having published many papers on this topic.
Gay drawings cartoons in Australia now lectures and trains subspecialists of the future on this condition and maintains a Visiting Medical Officer fertility subspecialist role at the Royal Hospital for Women in Sydney. As a female fertility specialist Raewyn is highly regarded by patients Sex surrogacy Maroubra her ability to explain sophisticated medical science in ways in which everyone understands.
Sex surrogacy Maroubra
Meet Dr Raewyn Tierney. Bondi Junction Fertility Clinic A fertility specialist will assess your overall reproductive health and conduct some simple tests to identify any existing reproductive conditions.
Visit clinic page. Kogarah Fertility Clinic Kogarah Fertility Clinic has an exceptional team of leading fertility specialists and a comprehensive choice of treatments.
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See how we can help. Website Visit website. In return this leads you back on track to where you can keep celebrating life, Maaroubra great sex and relationships in ways you once felt and will experience as this new and exciting chapter unfolds.
Sex surrogacy Maroubra gather history, and we build rapport. My approach is positive, personal and Fit escort Launceston. Good outcomes that stick usually are the fruits of working together patiently and hopefully over some time.
I offer tailor made Sex surrogacy Maroubra to suite your individual needs either as a couple, single or group dynamic.
She now lectures and trains subspecialists of the future on this condition and maintains a Marouhra Medical Officer fertility subspecialist role at the Royal Hospital for Women in Sydney. Body show and tell and body mapping is done with the lights on. My goal every time is to welcome a nervous, anxious person and have them leave relaxed, feeling good Massage annerley Albury empowered.
Advice for a parent who has Autism Spectrum Disorder. Holliday has worked with everyone from a post-op trans man who wanted to learn how to give and receive Marohbra, to something virgins looking to test the waters.
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Holliday herself is not certified, though she often Sex surrogacy Maroubra with licensed sex therapists throughout the country. IPSA skirts prostitution law in certifying its members because Marroubra doesn't acknowledge intercourse is part of Sex surrogacy Maroubra practice, according to Larry and other current and former surrogates. I do an oral meditation, describing my body, tip to toe—how it feels and functions—totally honestly," he says.
Larry Villarin is one of only ten certified male sex surrogates in the country— Buy tv online Newcastle he has sex with clients to sudrogacy them cope with their fears. is "pro-choice" and voted for same-sex surrogacy. Mr Daley replaced former Premier Bob Carr as the MP for Maroubra.
That Labor stronghold. Sex Therapy Sydney specialises in Sex Therapy, Relationship Counselling & Therapy for Couples, Individuals of all genders & sexual orientations.
❶We had so many firsts together—she didn't want to let go," Larry recalls. Is it worth seeing a psychologist? Find out. Somewhere along the line, they stopped trusting men.
I work with people to identify and overcome a range of physical and mental sexual health problems Sex surrogacy Maroubra help … Address: Suite54 Foveaux StreetSurry Hills NSW Phone: 02 8… Show phone number. Contact me now to clarify any concerns or queries and to make an appointment.
Dr Raewyn Teirney
Sending Send Verification. I may take a sexual history and therapy may involve asking some personal questions.
She was there, and she was wise. I mainly work at my home office, but I do travel. Aromatherapy Courses Beauty Therapy Courses. Welcome to Sex Therapy Sydney, Australia. Subscribe to The LoveLife newsletter for regular inspiration on sex, love and intimacy.|At the LoveLife Clinic we believe that a healthy sexuality is essential to good relationships and general well-being.
Sex & Relationship Therapy
Founded Free appliance removal Lismore leading sex and relationship expert Jacqueline Hellyer, with Alain Sex surrogacy Maroubra, the LoveLife Clinic provides specialised sex therapy and relationship coaching for men, women and couples, in person in Sydney, Australia, and via Surrogach around the Massage escape spa Wodonga reviews. From sexual dysfunctions through to spicing up a jaded love life, let us help you resolve your sexual issues and create Sex surrogacy Maroubra healthy fulfilling love life!
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While therapy helps overcome dysfunctions, coaching takes you beyond Sex surrogacy Maroubra to exceptional. Coaching in sex, love and intimacy will enhance not just your love life, but Sfx health and well-being in the whole surrogqcy life! Join Jacqueline on these beautiful immersive experiences and discover mindful, bodyful, soulful sex and Marlubra.
As one of only a handful of practitioners in Australia qualified as Mafoubra Psychosexual Therapist in Australia, Timber house plans Orange brings enormous experience to work with individuals and couples on all issues to do with sex, love and intimacy.
Read. He is passionate about helping individuals and couples understand themselves and their partners and co-create great relationships. He has a special interest in men's sexual health and well-being. He sees clients in person in Sydney, Australia, or via Zoom video conferencing.]
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https://www.baro4.com/sex-surrogacy-maroubra.html
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List of Free On-Demand Virus Scanners
More information will follow. Malwarebytes’ Anti-Malware software is a program you can use to protect your computer from spyware, adware, and other malicious software. Malwarebytes is distributed for free by the developer for personal use.
Install Malwarebytes & Scan Your Computer for Malware
Fake Anti-viruses, keyloggers, adware and rootkits are all forms of malware. Though parts of rootkits are detectable and removable by Malwarebytes, if you suspect that you may have a rootkit you should back up your data, securely wipe your hard drive including the boot sectors, and reinstall Windows.
The full scan which we recommend in this article can take several hours depending on the speed of your system and how full your hard drive is. We therefore encourage you to run this scan as the last thing you do on your computer for the day, leave it running over night, and check the results in the morning.
Instructions Step One: Starting the Program You will need to locate the Malewarebytes icon on your desktop and double click it to run the program. If you don’t see an icon like the one circled in the image below, you will need to have a technician come install it for you. If you have a local administrative account on your computer you can install it yourself.
The installer can be downloaded from the Malwarebytes Website ; click the “download now” link on their front page to start. Step Two: The Main Screen Depending on the version of Malwarebytes you have installed, it may prompt you to download updates before you see the screen below. If so, click the option to download updates now and skip to step 4. Otherwise, click on the “Update” tab which is boxed below. Step Three: Updating If the date of your last update is not within the past week, you should click the Update Now link, highlighted in red above and allow Malwarebytes to update.
A box will pop up and it will notify you when it is finished. If Malwarebytes fails to update, go ahead and continue to the next step, but if at a later step you need the assistance of a Computing services Technician, be sure to tell him or her that Malwarebytes failed to update. Return to the main screen by clicking “Dashboard” on the top row of tabs. Step Four: Starting the Scan Select “Full Scan” the highlighted option in the image below and click the scan button also highlighted.
A window will pop up asking which drives to scan, in most cases it automatically detects the correct drives so you can just click the scan button on the popped up window.
The scanning window looks like this: During the scan your anti-virus software may alert you to viruses it has found. This is because most anti-viruses scan any file which is accessed by any other software.
Since Malwarebytes is accessing files as it scans, it will trigger your anti-virus to also scan that file. Step Five: Results If Malware is detected on your system the screen will look like this when it finishes the scan: If there was no malware found the highlighted button will read Scan and will take you to the results screen.
Clicking on the highlighted “Show Results” button will take you to the following screen: At this time it would be a good idea to save anything you were working on and exit any programs you have running besides Malwarebytes. The malware removal process can sometimes cause unexpected errors or system shutdowns when the malware is to deeply entrenched in a system.
Everything that Malwarebytes has found will be displayed on the list. Clicking the button highlighted in the above image will start the removal process. Depending on how many infected objects Malwarebytes has found, this could take some time. Once it has finished removing all of the malware it found, you will either see a message box saying everything has been removed successfully, or you will see a window prompting you to restart in order to complete the removal process. If you have not already saved your work and closed other programs, you must do so now.
Delaying the restart for to long gives whatever malware has been found time to reinfect cleaned files, or infect new ones. It is recommended that you only delay the restart long enough to save your work. Closing Notes Congratulations, your system should now be malware free! If Malwarebytes found a particularly large number of malware related objects, you may want to rescan your computer.
Also, it is always a good idea to run your anti-virus scans regularly. There are other anti-malware tools out there. If you would like more details feel free to contact the help desk at x
What you need to know about Meltdown and Spectre 1gynRat asked the Hard Drives, NAS Drives, Storage forum if one should scan a flash drive or an external hard drive for malware–such as a virus or Trojan. I see no point in scanning every external drive every time you insert it. That becomes very annoying very fast. Yes, some antivirus programs do this automatically, but if yours does, I strongly recommend you turn the feature off. Which isn’t to say that you should never scan an external drive. Of course you should–when you think it’s appropriate.
VIDEO: [HOWTO] Run a Deep Scan for Malware
How can I get Malwarebytes to scan other drives (external/internal) as well as C/ drive on my Laptop. Because it must open and scan through every file on every drive, a full scan will free MalwareBytes Anti-Malware (MBAM) program and run the full scan option in . System Care Ultimate 11″ and just finished a Full Scan several hours ago. MalwareBytes Flash Scanner is an added tool to Malwarebytes’ Anti-Malware Pro version. It targets infected removable flash drives that utilizes.
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http://btr.isp.regruhosting.ru/malwarebytes-scan-multiple-drives/
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The warm up tent was introduced to the regatta when we moved to Dorney Lake.
Our Warm Up Tent is a very popular space dedicated to the preparation time athletes need ahead of a big race. We know it is not possible for every club or school to bring warm up ergs to Dorney Lake, thank to Concept 2 this is not a problem. By supplying erg machines, every competitor is freely able to access the warm up facility. This means everyone has the very best preparation ahead of racing.
We would like to thank Alex Dunne and our Partners at Concept 2 – getting every junior ready to race! Thank you!
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https://www.nationalschoolsregatta.co.uk/post/warm-up-tent-supported-by-concept-2
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I want to prepare for the IIT JEE 2020 from AK Vidhya Mandir Classes. However, there are other institutes such as the allen career Institute which one must take into consideration while joining A.K. What are the benefits of joining AK vidhyamandir classes over the coaching institutes like the Allen Career Institute?
The teachers of the AK Vidya mandir classes are really brillliant. All of the teachers have a really great experience with the teaching methodology since they have been teaching for like 5 to 10 years.
Moreover, the coaching institute also provides with the prepared notes, visual classes and other methological ways through which students can get a better grasp on the topic. So mwhat elese do you want?
It is an amazing decision to take admission in this coaching.
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https://www.studydekho.com/qa/145-i-want-to-prepare-for-the-iit-course-from-ak-vidhya-mandir-c
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If you have suffered a neck or back injury at work, you may be covered by Florida’s workers’ compensation system. Below is a short discussion of neck and back injuries at work. We encourage you to read the following information and contact our office for a free appointment with a Florida workers’ comp attorney.
Causes of Back and Neck Injuries
Sometimes a back or neck injury is caused by a single event, such as a fall from a ladder or tripping over a piece of machinery. However, not all neck and back injuries are caused by a single traumatic event. Back and neck injuries can develop over time from repetitive motions. In addition, some injuries are an aggravation of a pre-existing injury caused by work activities.
Jobs that require you to twist, bend, or lift items every day can increase the risk of a neck or back injury. It is also good to remember that a relatively simple work activity can result in a neck and back injury. You don’t have to fall from a high location or perform the same activity for 30 years to incur a neck or back injury at work.
Types of Back and Neck Injuries
The neck and back are composed of discs, nerves, and tissue. Damage to any element in the neck or back can create chronic pain and permanent damage. Because the spinal cord transmits messages from the brain to the other parts of the body, an injury to the back can result in a disruption of the pathways. When the brain cannot send messages to the rest of the body, the person can lose control of bodily functions and be paralyzed.
Examples of common neck and back injuries at work include:
- Whiplash or neck sprain
- Subluxation or dislocation
- Dislocated vertebrae
- Fractured vertebrae
- Torn or ruptured discs
- Injury to the tendons, muscles, or ligaments in the back
- Compression of nerves
- Herniated discs
A back or neck injury should not be ignored. If you are experiencing neck or back pain, you need to report the pain to your employer and request immediate medical attention. If your employer refuses to file a workers comp claim or allow you to seek medical attention, contact our office immediately for a consultation with a Boca Raton workers comp attorney.
Receiving Florida Workers’ Compensation for Back or Neck Injuries
In many claims for back and neck injuries, insurance companies dispute whether the injury occurred because of the employee’s work. Insurance companies like to claim that neck and back injuries occurred because of pre-existing problems. However, you may still be entitled to workers comp benefits if your back or neck injury is an aggravation of a pre-existing condition provided that your work was a substantial aggravating factor. The work aggravation must also cause a permanent and substantial increase of the pre-existing neck or back injury.
If your employer or insurance companies denies your back or neck injury, you won’t receive medical care or other benefits. However, you have the right to appeal a denial of your claim, but you must act quickly. If your workers’ comp claim has been denied, contact our Boca Raton workers comp attorneys immediately for a free consultation.
Call a Boca Raton Workers Comp Attorney for A Free Evaluation
If you have been injured at work, you have rights under Florida’s workers’ compensation laws. Contact The Broderick Law Firm, P.L. by calling 1-800-333-3903 to request a free, no-obligation consultation with a Boca Raton workers comp lawyer.
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https://www.thebrodericklawfirm.com/back-neck-injuries-florida-workers-comp-claim/
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ANALYSIS AND DESIGN OF DIRECT-COUPLED COMPUTER CIRCUIT ELEMENTS EMPLOYING MOS TRANSISTORS,
FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO
Pagination or Media Count:
An analysis is made of a circuit operating with direct connections using MOS transistors. Methods of designing single elements are discussed. Matching conditions of such circuits and the criterion of nondistortion transmission of given signal levels in logic circuits are also considered. It was found that if MOS transistors are used with induced channels the direct matching of logic circuits can be accomplished only by using the the sauce type of transistors. Analyses are made of the static characteristics and transient processes in a key circuit, and of the static condition of the trigger. The switching characteristics of NOT-OR and NOT-AND logic circuits are given. The design of these circuits is reduced to the design of a key circuit with one transistor.
- Computer Hardware
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https://apps.dtic.mil/sti/citations/AD0699235
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How to prepare a manuscript for Strategies- a PE journal
Movement Science Department
College of Liberal Arts and Sciences
Physical Sciences and Mathematics
The journal's goal is to provide information to physical educators and coaches that will assist them in their daily work by: Helping educators and coaches be more effective professionals Facilitating an understanding of the social, physical and intellectual aspects of motor performance and physical fitness Identifying current issues and or trends of importance to the physical activity and sport-related professions
Michigan Association for Health, Physical Education , Recreation and Dance
Johnson, Ingrid L., "How to prepare a manuscript for Strategies- a PE journal" (2014). Faculty Scholarly Dissemination Grants. 880.
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https://scholarworks.gvsu.edu/fsdg/880/
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What is Cepia? Our Favorite Non-Profit Organization
Let's Give Back!
I am an avid believer on all things are better when shared. When I started building this business I immediately thought to myself... I want to donate some of my profits to people in need.
Living in Costa Rica has given me a front row seat to some of the difficulties families face here in terms of opportunity, income, affordability of programs for kids, clothes, food, etc. When I was introduced to Cepia, a non-profit organization based in Costa Rica, I immediately wanted to help.
What is Cepia?
Laetitia Deweer, the co-founder and Vice President, started Cepia to promote culture, health, sports and education for children and teenagers and their families from poor backgrounds in the communities of Guanacaste, Costa Rica. Laetitia along with her self-less staff puts in time to open doors to local children who don't have access to much outside their front door.
They started an after-school program that now has 700 children..that's right, 700!!! How wonderful is that! These children can play basketball, go swimming, do jui jitsu, participate in art classes, surf lessons, soccer games, and learn english all around different communities in Guanacaste.
They also have a girls club which focuses on social & emotional issues, difficult families, abuse, learning issues, etc. This is a 40 week program put on by Cepia's wonderful volunteers.
I absolutely love our community here in Tamarindo! We have an exciting Surf Film Festival this weekend (March 13th-14th) and they are giving ALL proceeds to benefit Cepia. If you're in and around the area stop by for some fun! They have two evenings of surf films, food, music, and raffles, with an awards ceremony on Saturday night for the Robert August Surf & Turf. Check the link below for more details!
In case you wanted to donate to this wonderful organization, I have included the link here! Every little bit helps. We are all in this together.
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https://nalakai.com/blogs/news/what-is-cepia-our-favorite-non-profit-organization
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Fear is influencing you in every area of life. Fear in your relationships. Fear of missing out on pleasures of life.
Time and thought are route of fear. This creates anxiety. Then the anxiety becomes our first relationship. Fear of rejection failure uncertainty are all part of everyday life. Humans have learned to compromise and give in. This leaves them living only as part human. Another part remains on the sidelines, afraid to reveal itself. Afraid of being judged and possibly rejected. These fears create worry about what you may be missing out on.
These fears prevent people from doing new things. Fear of being different prevents change.
Fear of change is the standard of almost all of society.
There are a number of reasons why we are afraid of change. There is something you can do about that. Living as part of you is draining your energy. Reality is; there are over 7 billion people in this world. The few that will judge you for wanting to live as complete being will be replaced by people with courage and compassion.
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https://www.elitetantra.com/2016/07/
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Hours Monday-Saturday 8AM-5PM Year Round
Winter hours – Mon-Fri: 8-5 Sat: 8-5
Don’t forget to set your clocks back this weekend for Daylight Savings Time.
Also remember that our Ewe-Pullet hours change from Summer to Fall schedule.
We will be open from 8am to 5pm Monday through Saturday.
We are closed on Sunday.
“Starting on November 7th”
9th ANNUAL Fall Harvest Days 2016! Saturday, October 22nd 8 am to 5 pm
Harvest Day 2016 at Ewe Pullet Self-Service Used Auto Parts
Standard Wheel Barrow $40 or our 2-Wheel Black Hand-Cart $70
You may bring your own standard wheelbarrow or use one of our own if available!
Free Admission all day. (Standard Rules apply, 16 or older only in lot, no open toe shoes.)
Open for normal EWE-PULLET business as usual also.
EWE PULLET SCAVENGER HUNT!!! There will be 27 specially marked parts on cars in the facility. They will be marked with specific bright color paint. If you find any of the parts, pull them and bring them to the office, you will receive the same value as what it would cost to buy the part in credit on an EGG MONEY in-store credit card! There is also the OWNER / MANAGER showdown with two special parts that will be marked that are worth $50.00 Cash each!
Have you been getting your EWE PULLET price book stamped? For everyone that has turned a fully stamped Price Book sheet, there will be Drawings throughout the day. Turn in yours now if not you can start a new one for next year. Get stamps every time you buy from E.P.! Someone will win a new flat screen LED TV!
$1.00 Coupon for on site concessions for everyone signed in! Concessions by Nikki’s Burrito Express.
Inflatables for the kids– for this special day bring your kids. Childcare not provided and children must be supervised! Children’s are not allowed in the yard.
40-40-40 Rules and Notes On the day of the event, pull as many parts as you can fit in a Ewe Pullet Wheelbarrow or bring your own STANDARD 6 Cubic Foot single wheel Wheelbarrow (No modifications). Carefully position the items in the wheelbarrow and bring it to the staging area in front of the “Pull Barn”. When you get the signal, one person will need to push the items 40 feet within the 40 second time limit. New this year! Honk the horn-ring the bell!
RULES: Absolutely No Strapping of any sort.
No hoods, trunk lids, pickup boxes, bed liners or tailgates can be used as a stacking base.
Blow the horn before your 40 foot trip then ring the bell thru the course and you have 40 seconds to do it.
Lift Hoist cannot be moved to pull a motor or transmission until till ready to use. 3 available
We have parking available in field to the North thank you to the great neighbors we have.
We will allow tool drop off and parts loading only in main parking lot. Country club members will be allowed to park in the main parking lot as a benefit of membership.
Remember you can buy your Ewe-Pullet membership today
(We will not allow bulk scrap purchases of items such as aluminum rims and radiators)
Come and enjoy the day, even if just to watch!!!
Grand Opening of Marvin’s Gardens
Saturday, July 23, 2016
Ribbon cutting at 9:30am
This area will contain newer models and unique vehicles that
have served their time at the Full-Service Operation
Nordstrom’s Auto Recycling.
In order to help you better Ewe-Pullet has reorganized the tire section.
Stop in and check out the more than 100 tires ready for you.
Only at Ewe-Pullet.
Always thinking of you.
Ewe-Pullet new tire rack in progress, always with good selection of tires at the best prices in the area.
In honor of Earth Day on Friday, April 22, Ewe-Pullet and its sister, Nordstrom’s Automotive
Inc., are offering an Amnesty Day for you to bring your consumer
quantities of tires, oil, antifreeze, and car parts to
either location for free disposal.
Attention Web and App Users!
Our inventory of Self-Service vehicles is always Live at:
We are excited to add a New Service!
If you are a do-it-yourselfer or an independent mechanic looking for a used part we don’t have available this might be for you!
You can use the mobile friendly website or the App for your Droid or Apple
to “smart search” our vehicles or Row52 participants.
Vehicle Smart Search, Parts Pullers, Parts Wanted, Parts For Sale, all available.
Download or Link up today!
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https://www.ewepullet.com/author/ricardo/page/6/
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14873276
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JoAnn Gregoli, of Sparta, is an event planner by trade. And now, she's a super mom.
"I have reached out to 50 moms and moms' groups and sewing clubs to be able to make masks for the healthcare workers on the front lines," she said.
Her group connected on Facebook from various locations, 50 women -- most of whom have never met -- sewing around the clock, making thousands of masks that are either equal to or better than N95s.
"What started this whole thing is I have two children on the front lines," she said. "One is a physician assistant, and one is a detective. And they alerted me there was a need for masks in some of their areas."
Gregoli has now supplied masks to 15 hospitals and nursing homes in New Jersey and five hospitals in New York. And part of her family traces its roots back to a famous helper, Rosie the Riveter.
"My son-in-law is the grandson of the original Rosie the Riveter from Norman Rockwell," she said. "They were neighbors in Vermont. So when Norman Rockwell actually painted that picture, it was his grandmother who was the model."
She is so fiercely proud of how women from Sparta to Madison have rolled up their sleeves.
"We produced over 5,000, just moms sewing from home with their kids," she said. "It's crazy that they even have the time to do that while they're trying to teach school to their kids simultaneously. It's nuts.
She says that without being asked, companies have sent candies and chapsticks for her to give medical staff, as well as materials to make the masks.
"Home Depot sent me well over 50 boxes of supplies, which were all fabric and elastic, crazy, arrived at my home," she said. "So people don't even know who's stepped up to the plate."
And she hopes the efforts will help alleviate a critical shortage in the fight against the virus.
"We are the Rosie the Riveters of our generation," she said. "Trying to make a difference, one mask at a time, a grassroots effort."
MORE CORONAVIRUS COVID-19 COVERAGE
Grieving the lost: Tri-State residents who have died
New York state
New York City
Where are the testing centers
See how our communities are making a difference
Free educational resources for parents and children
How you can help victims of coronavirus
Share your coronavirus story with Eyewitness News
Stimulus check scams and other coronavirus hoaxes
Coronavirus prevention: how clean are your hands?
Centers for Disease Control and Prevention on coronavirus
Coronavirus cases by NJ county
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https://abc7ny.com/coronavirus-nj-new-jersey-update-curfew/6105032/
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14873277
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As the founding attorney at the Law Office of Zach Horsley, LLC, Birmingham lawyer Zach Horsley helps those with family law concerns navigate the legal system.
Before the formation of his present firm, Attorney Horsley worked at the public defender’s office in Pikeville and practiced at another firm.
He is a graduate of Auburn University and the Appalachian School of Law. Mr. Horsley is licensed to practice in Alabama and the District Court of Northern Alabama. Learn more by contacting his firm today.
Rate : $$$
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https://lawtally.com/lawyers/zachary-kyle-horsley/
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14873278
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Following an automobile accident in December of 2006, the plaintiff was emergently transported to a nearby hospital. At the hospital, he was found to have suffered multiple left rib fractures and a grade II-III splenic laceration in the accident. The initial exam indicated that he was suffering from pain in his left shoulder and side, and that he was tender in the LUQ. He was given at least one or two doses of morphine and one dose of Toradol for his pain prior to being taken to the radiology department. A single x-ray technician took the plaintiff by gurney to the radiology department for plain films and upon arrival asked the plaintiff to get up and walk into the room and stand on his own for shoulder x-rays. After the first film was taken, when the x-ray technician approached the plaintiff to position him for the second view, he clearly reported that he was very dizzy and unable to stand. The x-ray technician allowed him to sit for a few minutes, but then again asked the plaintiff to stand to be positioned for the second film. After positioning him, the x-ray technician left this trauma patient, who was suffering from dizziness and lightheadedness and who had just received at least two narcotic pain medications, alone in the room, unsupervised. Just after the x-ray technician left the room, the plaintiff suffered from another syncopal episode and violently fell, striking his head.
Two nurses and an emergency department physician were summoned and found the plaintiff on the floor, pale, cool, and diaphoretic, with frank blood coming from his left ear. Following the incident, in addition to the plaintiff’s ongoing LUQ pain, he was found to be suffering from amnesia and palpable soft tissue changes in the left lower occipital region, with blood in his ear. The plaintiff was sent for CT scanning to further define his injuries. The head CT scan identified a left occipital bone fracture and subdural hematoma. Comparison with a second set of films identified a developing subarachnoid hemorrhage as well. The decision was made to transfer him to another hospital. He spent a week hospitalized and underwent surgery to treat his injury months later.
Following this fall, the plaintiff was diagnosed as having suffered a left basilar skull fracture and a left posterior occipital bone fracture, which resulted in a subcapsular hematoma. The plaintiff was also diagnosed with a subarachnoid hemorrhagea nondisplaced fracture of his left occipital mastoid and the walls of his auditory canal. He developed sinus thrombosis and air fluid leaks through the walls of his air cells, middle ear cavity and external auditory canal. The plaintiff continued to suffer from ongoing headaches, dizziness, and hearing loss long after his discharge from the hospital.
The plaintiff continues to suffer from nausea, vertigo, headaches, short term memory loss, word finding difficulties, and extreme pain and fatigue. He has also suffered from significant hearing loss, with tinnitus, vibrations and pressure in his ear. Noises and tiredness aggravate each of these symptoms and cause additional episodes of dizziness and vibration. His permanent hearing difficulties have affected his employment and family activities throughout his recovery and will likely always be present.
Verdict/Settlement: The parties settled at mediation, without suit being filed for a confidential amount.
Plaintiff’s Counsel (please include name and firm):
Mark A. Abramson, Esquire and Holly B. Haines, Esquire
Firm: Abramson, Brown & Dugan
1819 Elm Street
Manchester, NH 03104
Name of Case/County: Rockingham County
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https://www.arbd.com/verdictsettlement-2/
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14873279
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Reorder gear by searching for your Squadron:
We are your Snacko and Mess Officer continuity book and we want to make the changeover a seamless transition.
Custom patches for the Combined Joint Task Force Phoenix. Our CJTF Phoenix patches are 100% embroidered with Velcro backing.
CLDJ Air Ops Air Traffic Control Patch
Priced for Quantity of 100
Qty - 100
Task Force Phoenix OCP Patch
Your shopping cart is currently empty. What a perfect time to check out our great selection of customizable products!
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https://www.aviatorgear.com/c-7030-cjtf-phoenix.aspx
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14873280
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Ofsted recently praised an outstanding central London school for the fact that its “students receive excellent advice about their career options, training and employment opportunities from year 7 onwards.”
The school makes good use of branding to raise the profile of post-16 progression and support. Students are encouraged to think about the behaviours and skills that help them to open the “DOOR” – Dedicated, Organised, Opportunities and Resilient – to their careers.
A comprehensive school careers website includes success stories from former students and provides access to a range of resources to help choices at key points of transition. The school has a Unifrog licence, which enables them to support exploration of higher education and apprenticeships. The annual report to governors noted an increase from 6% to 20% in the number of students accessing apprenticeships.
Communication of the provision is a strength and the school sends out a detailed monthly bulletin to students and families. The school also issues a parents’ handbook in year 7 to explain their careers offer. The head of employer engagement is making plans to improve the physical careers space at the school, has visited other schools and colleges to develop her ideas. The school has excellent links with the employer community and its students have access to a wide range of employer encounters.
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https://www.careershubcios.co.uk/case_studies/embedded-advice-about-careers-and-lmi/
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14873281
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|Make An Offer|
|Shaper of Board|
|Size of Board|
|Surfboard Fin System|
|Type of Tail|
- Selection Required: Select product options above before making new offer.
- Error: There was an error sending your offer, please try again. If this problem persists, please contact us.
5ft 3in Hayden Shapes “Merlot” Ref #44111
W 18 1/8″
The Haydenshapes Merlot is another signature model by Craig Anderson. The Merlot has been designed for high performance surfing in small to medium waves. It maintains its performance when put on rail, through the large single concave to double vee. The hip in the tail loosens the board up, helping with critical surfing in the pocket.
1 in stock
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https://www.usedsurfboardshawaii.com/product/5ft-3in-hayden-shapes-merlot-ref-44111/
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14873282
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There are some key things that need to be considered before committing to any produce supplier. If you are operating a food-services company or any hospitality venue, knowing where your food is coming from is key to your success. The reality is, quality food and the farms they come from become increasingly important. Ultimately, considering the important things about where your food is coming from can make a big difference in your business. Here are the key things that you absolutely must consider before you commit to a produce supplier.
Where Your Produce Supplier Purchases Their Produce
Knowing where all your produce comes from is essential to the hospitality industry. A key question that you must ask your produce supplier is where they purchase their produce. This integral question will provide you with insight that can help steer you in the right direction when you’re choosing the perfect supplier for your specific and unique needs.
Being Knowledgeable About All The Products They Carry
When you need any questions answered, your hope is that your supplier will have those answers for you. Being knowledgeable about all the products they themselves carry is a great way to comb through the less than stellar produce suppliers and find one that gets you what you are looking for when it comes to the food being delivered to your business.
Does Your Produce Supplier Offer Online Ordering?
Another key component that needs to be factored into your decision-making process is the ability to order produce online. Being equipped with the latest technology available can make a massive difference in how you choose to go with one supplier over another. The reality is, online ordering is a very convenient option for many looking for premium produce suppliers.
There’s nothing more essential than knowing where exactly your food and produce is coming from. Taking the time to quality control your produce suppliers to find out what best suits your needs can make a massive difference in the quality of your produce and the ultimate success of your business overall. Ultimately, finding produce suppliers that cater to your specific needs is the best way to approach the decision-making process to make it as simple and convenient as possible.
BAYWATER FARMS HAS THE RIGHT PRODUCE FOR YOU
Baywater Farms is a family-owned and operated farm servicing Baltimore, Washington D.C., Maryland, Delaware beaches, and the Eastern Shore. We are capable of meeting the demands of your produce distributor, restaurant produce supplier, CSA produce supplier, or wholesale produce supplier while maintaining the integrity and character of a small farm. When you work with Baywater Farms, you work with an experienced, ethical, and local farm dedicated to providing the highest-quality heirloom produce.
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https://www.baywaterfarms.com/blog/things-to-consider-before-committing-to-a-produce-supplier/
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14873283
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& Operated by Verizon
The "TracFone" Networks, the largest family of Prepaids in the US, are
operated by Verizon. They
control 11 different Prepaid carriers in the US, TracFone
being the largest. This list provides links and
other useful data, listed
alphabetically. The advantage is that with these services you use the
same wireless networks as the major carriers at a lower price. The
disadvantage is that these carriers will eventually use the
Verizon wireless infrastructure exclusively. This could mean coverage, plan and name changes.
variation of T-Mobile's own
Prepaid before their acquisition of MetroPCS. GoSmart was
acquired by America Movil in 2016 and now operates
more like other Tracfone prepaids. GoSmart offers some very low
price points and give you "unlimited" data and will "throttle" your web
speed after your allotment.
have a very limited number of
phones available, but they allow you to bring your own phone.
Broadband access is limited to 3G downloads but allow 4G-LTE
access to Facebook and Messenger. Talk, text and data roaming is
available for no extra charge in Mexico and 15 other Latin American
originally developed to offer a pure 10
cents a minute wireless experience but has evolved to a network that
has a slight benefit toward families.
of our recommended prepaid
services. They use the entire Verizon Wireless network with
off-network Voice and Text roaming available at a reasonable per minute
rate. America Movil acquired Page Plus in 2014.
supplies service to those customers who qualify for LifeLine services,
a government-supported telephone program. Plans are Free or at a very
low cost. Safelink is only offered in certain states of the US
phones are confined to the T-Mobile network and give you lower rates in
return for more restricted network access. The name "SIM-ple"
originated with them being a "SIM-only" service, but now they offer
offered as an exclusive product to be sold at Wal-Mart, Straight Talk
also offers their phones and service online. They offer single-network
phones which allows a choice of one of the national carriers, and a
Bring-Your-Own-Phone plan that offers access to multiple networks.
Talk also offers Hot Spots and Wireless Home Phone Systems.
- ABOUT STRAIGHT TALK COVERAGE:
Talk, along with their related prepaid brands, regularly negotiates
with all the wireless networks to get the best price to use
infrastructure. Depending on your service plan, the carrier
used in a certain location this year may be different than the one you
used last year. Straight Talk's plans are dependant on your
model and may be limited to just one major network or one technology
(CDMA or GSM). Your phone may also access one of the smaller,
regional networks. In most cases, you won't know which
you are using and coverage won't change appreciably.
- STRAIGHT TALK Review
- STRAIGHT TALK
- STRAIGHT TALK Online
largest wireless service in Mexico and their new US
service gives you a Mexico-calling connection with their "Extended
Nation" plans. There are several plan levels that include Roaming in
Mexico, including a 7-day plan. Coverage in Mexico is mostly on the
superior Telcel Mexico network. In
the US, Telcel offers all the same
characteristics of the Straight Talk network, including a "Bring Your Own Phone" plan that
roams nationally on most available GSM networks. Telcel coverage in the
US uses the T-Mobile network. They also offer Spanish language customer
Wireless was created to be sold at Walmart, like Straight
but at different price points, and is limited to the Verizon
and not the roaming partners
available on Straight
largest Prepaid service in the US and the largest of America
Movil's US networks. They
have created a network with nationwide coverage using roaming
agreements with various carriers.
Prepaid was never part of the "Tracfone" networks, but now that Verizon
owns all the Tracfone carriers, it should be assumed that they all
have, or will have, a cooperative realtionship. Verizon Prepaid was
never a strong product by itself so there is a chance it could be
eliminated in favor of one of the other networks, or it could become
the 'catch-all' for any of the other Tracfone carriers that could cease
to exist and have their operations and customers switched to Verizon
created their own brand of wireless using the T-Mobile Network. America
Movil acquired the Walmart Family Mobile service and now operates it
within their TracFone operation. The phones and plans offered are
similar to other America Movil products and will continue to be sold at
Walmart stores and Walmart.com. While the phones should
to use the T-Mobile network, America Movil may make adjustments and
their maps show coverage available on roaming partners. Their
service is competitive with other prepaids and they may
be offered at price points that may better fit your usage.
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http://mountainprepaid.com/reviews/tracfone-prepaids.shtml
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14873284
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the objective analysis and evaluation of an issue in order to form a judgment.
Five easy steps to critical thinking and reading critically
Now more than ever, it matters that we all think critically and apply that to what information we ingest. In light of recent exposure of false news being shared that has had an impact on national elections, believing everything we read comes with extreme consequences. To that end, I am more convinced than ever that one thing I can do is to apply what I learned in my schooling about reading critically.
The internet is a source of a lot of information and misinformation. A data point from meetings I attended this week – over 90% of the content that is on the Internet has been created in the past 2 years. It will continue to proliferate and grow, making it harder and harder to filter and fact check. We all want to believe that what we read is true, but that can’t be the case. To quote my mom (and many others), fool me once, shame on you – fool me twice, shame on me.
Here are my suggestions – I’m sure there are many others, but I wanted to keep this brief. Feel free to add your own to the list.
- Read broadly. If you only get your news from a single source, you run the risk of getting tunnel vision.
- If a topic or story seems ludicrous, fact check it. Look at other sites to see if they are reporting it as well. Select sites that have conflicting views and see how it’s being reported from their perspective.
- Know who is behind your news. Look at who the publishers and editors are – you can very quickly get a sense of bias or point of view by doing this. Many media sources use names in ways that make them seem like other sources – this can be intentional or not, but it is important to understand what you are reading and who is sharing it.
- If you find yourself only ever saying “Yeah – that’s my kind of news” you are probably in an echo chamber. News that is based on the basic journalistic principle of “Who, What, Where, Why, and How” will often give you news that makes you uncomfortable because it runs counter to your personal beliefs or bias.
- Synthesize what you read – get the various sources, look for themes, and then THINK. I can’t stress this enough. News should not tell you how to think or feel. It should inform and you need to draw your own conclusions. It’s why I stopped watching any local or network news. I can’t abide being told how I should feel or think. I use my brain every day to do this. The minute I stop, I become part of the problem. And that’s not OK with me.
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https://erinlearywrites.com/2016/11/18/critical-thinking-5-easy-steps/
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14873285
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Dufont Faes Construction are a preferred contractor for a range of prominent clients including local authorities, social housing providers, government agencies, historic estates and education departments.
Transforming homes, buildings and environments – Building for a Better Quality of Life.
Conservation and Heritage
Focusing on speciality conservations, restoration, repair and refurbishment or historic buildings and estates.
Delivering new build projects to high quality, cost effective standards, meeting the needs of tomorrow through design and sustainability.
Specialist Aids & Adaptations
Making a difference to the day-to-day lives of disabled and vulnerable people through sensitive alterations to their surroundings.
Repairs & Maintenance
Providing a proactive, responsive, right first-time service everywhere from social housing to high profile historic estates.
Contact our head office and talk to one of our friendly, experienced team
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https://www.dufontfaes.com/construction/
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14873286
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Healthcare Industry News: Artis zeego
News Release - May 3, 2010
Hansen Medical and Siemens Announce Agreement to Co-Develop Integrated Products to Advance Treatment of Irregular HeartbeatsMOUNTAIN VIEW, CA., May 3--(HSMN NewsFeed) - Hansen Medical, Inc. (NASDAQ:HNSN ) and Siemens Healthcare today announced joint development and cooperation agreements to co-develop integrated products designed to help simplify complex cardiac procedures for the diagnosis and treatment of cardiac arrhythmias, or irregular heartbeats.
The agreements will enable the creation of integrated product solutions by combining Siemens' Artis zeeŽ family of angiography systems and the syngoŽ DynaCT Cardiac (angiographic computed tomography) with Hansen Medical's SenseiŽ X Robotic Catheter System. The integrated products will be designed to enable electrophysiologists to perform complex cardiac procedures with greater confidence and improved efficiency.
Cardiac arrhythmias can drastically reduce the quality of life and can also lead to serious health risks including heart failure and stroke. Nearly 550,000 new patients are diagnosed with cardiac arrhythmias in the United States each year, and arrhythmias cause approximately 250,000 deaths annually according to the Heart Rhythm Foundation and the American College of Cardiology. The condition also affects over 4.5 million people in Europe.
"For Siemens Healthcare, the joint development and cooperation agreement with Hansen Medical is another important step towards integrated solutions advancing the quality of care for an increased number of patients," said Dr. Heinrich Kolem, CEO Angio-, Fluoroscopic- & Radiographic Systems for Siemens. "We believe the combination of our efforts will enable us to offer our customers significant improvements in workflow during the treatment of cardiac arrhythmias."
The Sensei X system is the next generation flexible robotic platform that integrates advanced levels of 3D catheter control with 3D visualization. This innovative technology is designed to provide fine catheter control while mapping in 3D to enhance the physician's ability to access hard-to-reach cardiac anatomy and maintain stability during complex cardiac arrhythmia procedures.
Siemens' Artis zee systems including Artis zeego, the first multi-axis system based on robotic technology, are ideal for cardiac diagnostics and interventions, even hybrid procedures. The flexible and ergonomic design enables clinicians to optimally adapt the system configuration to focus on interventional cardiology, pediatric and electrophysiology applications with tableside operation. In addition, the syngo DynaCT Cardiac enables CT-like imaging of the heart with an angiocardiographic system during cardiac procedures, so that physicians can visualize the left atrium and pulmonary veins in 3D.
"Hansen Medical is committed to improving the clinical experience of electrophysiologists worldwide, and we are extremely pleased to be collaborating with Siemens Healthcare to develop integrated products that offer comprehensive solutions," said Frederic Moll, M.D., CEO, Hansen Medical. "These joint agreements will allow both companies to offer enhanced procedural planning and workflow, as well as improved capabilities to customers. The design of our integrated solution will improve visualization and instinctive driving within 3D anatomical models, resulting in improved catheter navigation and contact while inside a patient's heart."
The Sensei X platform is built upon an open architecture design and Hansen Medical's commitment to open architecture allows for successful collaboration with a broad range of leading imaging companies.
About Hansen Medical, Inc. Hansen Medical Inc., based in Mountain View, Calif., develops products and technology using robotics for the accurate positioning, manipulation and control of catheters and catheter-based technologies. Its first product, the SenseiŽ Robotic Catheter system, is a robotic navigation system that enables clinicians to place mapping catheters in hard-to-reach anatomical locations within the heart easily, accurately and with stability during complex cardiac arrhythmia procedures. The Sensei system is compatible with fluoroscopy, ultrasound, 3D surface map and patient electrocardiogram data and was cleared by the U.S. Food and Drug Administration (FDA) in May 2007 for manipulation and control of certain mapping catheters in Electrophysiology (EP) procedures. The safety and effectiveness of the Sensei system for use with cardiac ablation catheters in the treatment of cardiac arrhythmias, including atrial fibrillation (AF), have not been established. The Sensei system is CE Marked for use during EP procedures, such as guiding catheters in the treatment of AF. Additional information can be found at www.hansenmedical.com.
Forward-Looking Statements This press release contains forward-looking statements that involve risks, uncertainties, assumptions, and other factors, which, if they do not materialize or prove correct, could cause Hansen Medical's results to differ materially from those expressed or implied, by such forward-looking statements. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including, statements containing the words "plan," "expects," "believes," "goal," "estimate," "may" and similar words. Hansen Medical intends such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 21E of the Exchange Act and the Private Securities Litigation Reform Act of 1995. Important factors that could cause actual results to differ materially from those indicated by such forward-looking statements include, among others, product development risks, potential safety and regulatory issues that could delay approvals, and the scope and validity of intellectual property rights applicable to products being developed. These and other risks are described in greater detail under the heading "Risk Factors" contained in our periodic SEC filings.
Hansen Medical, Heart Design, Hansen Medical & Heart Design, Sensei, IntelliSense and Fine Force Technology are registered trademarks, and Artisan, Artisan Extend, Lynx, CoHesion and Instinctive Motion are trademarks of Hansen Medical Inc., in the United States and other countries.
Artis zee and syngo are registered trademarks of Siemens AG.
Source: Hansen Medical
Issuer of this News Release is solely responsible for its
Please address inquiries directly to the issuing company.
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https://salesandmarketingnetwork.com/news_release_bs.html?pipe=0000ac177000191&ID=2030741&key=Artis+zeego
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14873287
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Barrow AFC are pleased to announce the appointment of Levi Gill as the club’s new Chief Executive Officer.
Levi will work in collaboration with the Board of Directors and be responsible for all administrative and commercial activities at the Club.
Speaking on the appointment, Club Chairman Paul Hornby said, “Levi has made a real impression on the owners during his time representing the Bluebirds Trust on the Club Board. We knew that a return to the Football League would require a more full-time, professional approach to the Club’s off-field operations and we were always keen to appoint locally if possible. In Levi we are delighted to have somebody who knows the Club and can hit the ground running as we continue through a busy period for Barrow AFC.”
Levi added: “I’m obviously incredibly honoured that the Board have put their faith in me to take up this role. Last season exceeded all of our expectations and we now enter our first League Two campaign with a squad and a manager that we feel are both ‘EFL ready’. My job is to ensure that off-field we can reach that same level. There are countless new requirements set for our club by the EFL and I’m looking forward to ensuring that we meet these as well as delivering the best possible experience for our staff, our commercial partners and most importantly our supporters.”
Levi will formally join the Club next month, and will spend the next two weeks transitioning into the new role and coordinating the Club’s ongoing process of re-opening as COVID-19 restrictions ease. As part of the transition, Levi will resign from his role as the Bluebirds Trust Director effective from 24th July.
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https://www.barrowafc.com/news/2020/july/220720-barrow-appoint-levi-gill-as-chief-executive/
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14873288
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A carnival in Boynton Beach sponsored by students at Spanish River High School in Boca Raton starts today and continues through Sunday.
Its purpose is to raise money for the school's DECA club and the school's Project Graduation party.
DECA is a nationwide high school association of marketing students. Twelve students from Spanish River's club will compete in a national competition in Detroit.
Project Graduation is a countywide program that offers alcoholand drug-free parties for graduating seniors on their graduation night.
The carnival, which will include events and carnival rides, will be held today and Friday from 6 to 10 p.m. and noon to 10 p.m. Saturday and Sunday in the parking lot of the Glendale Federal Bank at Congress Avenue and Woolbright Road in Boynton Beach.
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https://www.sun-sentinel.com/news/fl-xpm-1994-04-21-9404210621-story.html
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14873289
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It goes without saying that there is a certain standard of care that we expect when we or our loved ones are seeking medical care and treatment. If this standard is not met, it can have serious and potentially life changing consequences. At Clarke Jeffers we offer advice and guidance on how to deal with medical negligence claims. Whether you have suffered injuries or loss because of a misdiagnosis or whether you were injured because a procedure was done incorrectly, we have a wealth of experience that can assist you with your case.
“We don’t put our health or lives in many people’s hands but when we do, we are entitled to the highest possible form of professionalism. When this slips it needs to be accounted for.”
-Victor Clarke, Managing Partner.
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https://cj.ie/medical-negligence/
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trying to get a return for their
investors, a competitive market
has taken root that would require
a major catastrophic loss event to
alter the current playing field.
“What I’m telling my folks
is this is the new normal,” says
Bob Greenebaum, executive vice
president, Casualty Practice Group
Leader at Swett & Crawford.
Speaking to the abundant capital in
the marketplace and what that has
meant for the ability to withstand
larger losses, Greenebaum notes
the industry hardly flinched after
2012’s Superstorm Sandy—which
SAN DIEGO, CA. WWW.NAPSLO.ORG
WELCOME continued on page 4 A
Welcome to San Diego and the 2015 NAPSLO Annual Convention.
We’re pleased to welcome a record
number of attendees this year with
an exceptional lineup of networking, social and educational events,
thanks to the great work of our
If you haven’t already picked
up your registration packet,
you may do so this morning in
the Harbor Foyer on Level 2 of
the Manchester Grand Hyatt.
Programs are scheduled through-
out the meeting, beginning with
the Opening Reception tonight
in San Diego’s Embarcadero Park.
NAPSLO’s Next Generation will
NEW NORMAL continued on page 6 A
Gil Hine Hank Haldeman
We do. Colony Specialty’s Casualty division launched a “zero deductible”
program for smaller accounts, is perfecting the art of the same-day quote
turnaround, and secured $25 million in excess capacity to better serve
Technology and Service focused on your Success.
Rapid-fire quotes and zero deductibles.
Who does that?
Adjusting to the
With a huge influx of capacity,
significant rate decreases and fierce
competition for business, emphasis on
value delivered is more critical than
ever for the Excess & Surplus market
BY PHIL GUSMAN
Anyone who has been in the insurance industry long enough has heard it before: “This
market cycle is different.” This time,
though, even veteran Excess and
Surplus Lines professionals believe
it might well be the case.
A combination of excess
capital, much of it from nontraditional sources, and, to a
lesser extent, the ability to put
data and analytics to better use
means the industry can absorb
larger losses than ever before.
With continuous new entrants
armed with so much capital
September 9, 2015
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https://www.property-casualtydigital.com/propertycasualty/napslo20150909
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Our Everest Base Camp Trek 13 Days is a journey that assembles all the best features of the Everest region. This Everest Base Camp trekking is a key to explore the Everest region and the Everest Base Camp.
This 13 Days Everest Trekking captures the essence of the Nepalese mountain life. The trek passes through the different Sherpa villages. Namche Bazaar is the Sherpa Hub in the Khumbu region. It is the only gateway to Everest. During the trek, you can explore the mountainous lifestyle of Sherpas.
The trail passes through the dense forests, riverbanks, and refreshing natural terrains. The trek is extremely beautiful and joyous.
The unique villages at Phakding, Namche Bazaar, Tengboche, and Dingboche are lovely. The local people are hospitable and cheerful. They are ever ready to reply to your ‘Namaste’ with a cheerful face.
Start off the trek from Kathmandu with a thrilling flight to Lukla. Besides being thrilling, the fight is equally scenic. Enjoy the bird’s eye views of the Everest region.
Enjoy the flight while the plane flies above the green hills, valleys, and the snowy mountains. Hold on to your seats while the flight lands at Lukla. Lukla is one of the most dramatic airstrips on the planet.
The 360 degrees view of Mt. Everest and Khumbu glacier from the famous vantage point of Kalapatthar is heavenly! The jovial trekking journey displays the amazement of the Everest region.
The streaming rivers, boulder-dotted pastures, herds of yaks and mountain goats are magnetic. The Chortens, Gompas, Player flags, and Monasteries are the reflections of Buddhist practices.
Immerse yourself in the alluring sights of the majestic mountains. The hills, diverse terrains, rivers, glaciers, gorges, and the snowy massifs are beautiful. The Everest Base Camp Trek for 13 days is a trek of a lifetime!
Trip Highlights of Everest Base Camp Trek 13 Days
- The amazing mountain flight to and from Lukla – Kathmandu.
- The Tengboche Monastery and the blissful moment during the evening chants and prayers.
- Kalapathar, the best viewpoint of Mount Everest.
- The Everest Base Camp, the footstep of the world’s highest peak.
- The unique traditions and cultural practices of Himalayan Sherpas.
- The hospitable local people.
- The mesmerizing valleys, lovely terrains, and diverse mountains topology.
- Amazing panoramas of Everest, Lhotse, Nuptse, Amadablam, Thamserku, and others.
Outline Itinerary of Everest Base Camp Trek 13 Days
Day 01: Arrival and transfer to your hotel in Kathmandu.
Day 02: Rest and arrangement day in Kathmandu.
Day 03: Kathmandu – Lukla, and trek to Phakding (2,562m, 35 min flight, 6.2 km, 3-4 hrs)
Day 04: Phakding – Namche Bazaar (3,440 m, 10 km, 5-6 hrs treks)
Day 05: Rest, Acclamation in Namche, Explore Namche.
Day 06: Namche Bazar – Tengboche (3,870m, 10km, 5-6 hrs)
Day 07: Tengboche – Dingboche (4,360m, 5-6 hrs, 8km)
Day 08: Dingboche – Lobuche (4,940m, 4-5 hrs, 7 km)
Day 09: Lobuche – Gorakshep (5,160m) – Everest Base Camp (5,364m) Gorakshep (7-8 hrs, 15 km)
Day 10: Gorakshep – Kala Patthar (5,545m) – Pheriche (4,280m, 15km, 7-8 hrs)
Day 11: Pheriche – Namche Bazaar (3,440m, 15km, 6-7 hrs)
Day 12: Namche Bazaar – Lukla (2,642m, 18km, 6-7 hrs)
Day 13: Lukla – Kathmandu (1,300m, 35 min flight)
Best Time for Everest Base Camp Trek 13 Days
Autumn is the season that sees the highest trekkers in the Everest region Treks. During Autumn, the weather is mild and suitable for Everest Base Camp Trekking. The sky is bright and clear. The views of the gigantic Himalayan massifs towering to touch the sky is so perfect.
It is the time when the entire region wakes up after long winter hibernation. As the region warms up day by day, the animals and birds are more active. The surrounding vistas, wide terrains, and distinct landscapes are enchanting.
Spring is the most popular time for EBC trek after Autumn. Spring arrives right after the monsoon rain ends. The monsoon swipes away all the dirt and impurities in the atmosphere. So, the surrounding becomes cleaner.
Spring is the time when the hills blankets under the petals of colorful flowers. You will walk through the alluring Rhododendron forest. The temperature is mild for day hikes and isn’t as cold as in winter during the night.
Monsoon and Winter are off seasons for Everest Base Camp Trek. However, there are some trekkers who have desires to trek during these times. The trek can be quite difficult than in the best seasons, yet the trek is doable.
In monsoon, the region is wet due to frequent rainfall. The sky isn’t clearly visible. Dark clouds hover above you, mostly in the evenings and mornings. Also, the summer bugs and leeches are active on the trail. Carry some insects repellent and table salts (for leeches).
Winter is the coldest season in the Everest region. Most of the high passes and high altitude trail buries under huge piles of snow during mid of the winter. The night temperatures are very less, far below the freezing temperature. Also, the weather is frequently varying in winter.
Despite that, with appropriate gears, the Everest Base Camp trek is possible throughout the year.
Weather and Temperature at Everest Base Camp
Autumn (September, October, November)
Autumn is the time when the Everest region inches towards the cold weather. The autumn-sun isn’t as warm as the summer sun.
The daytime temperature ranges between 20 to 12 degrees. The nighttime temperature varies between 3 degrees to -7 degrees. The temperature decreases as the month traverse from September to November. November is the coldest month in Autumn.
Spring (March, April, May)
Spring is the colorful season at Everest. The entire region progresses towards warm weather in Spring. Spring is a glorious time to visit Everest.
The daytime temperature in March is around 12 degrees. The temperature goes up to 15-16 degrees in April. May is the hottest month of Spring. The daytime temperature in May reaches around 20 degrees.
Nights are warmer and bearable. Sometimes the temperature drops to zero at night. But the temperature is not alarmingly low as in winter. The nighttime temperature ranges between -8 to -5 degrees.
Winter (December, January, February)
Winter is the driest season at the Everest Base Camp. In winter, the temperature at the lower elevation is bearable. But as you ascend to higher elevations, there will be heavy snowfall. The temperature is very cold there. The average temperature ranges between max 20°C during days to -17°C at nights.
Summer (June, July, August)
Summer months have the hottest temperature. The daytime temperature in summer varies between 20 to 25 degrees. The maximum temperature occurs in June and July. The nights are colder than the days. The night temperature ranges somewhere between -3 to 5 degrees.
Why Everest Base Camp Trek 13 Days?
To View the Impressive Himalayas
During the Everest Base Camp Trek, you can see the best panoramas of the towering peaks including Mt. Everest, Mt. Lhotse, Mt. Nuptse, Mt Thamserku, and Mt. Ama Dablam, and several others. The mesmerizing snowy peaks are enchanting!
The Everest Base Camp trek passes through many Sherpa Villages. Also, we will walk into Namche Bazaar, a Sherpa town in the Everest region. Walking into the Sherpa villages is a beautiful experience. The local Sherpas are hospitable and cheerful. We will walk through villages like Pheriche, Tengboche, Dingboche, Namche, Lobuche, etc.
Kalapathar is the best vantage point of Mt. Everest. From there you can see the 360 degrees panorama of the gigantic Everest. You will also see the alluring vista of Khumbu glacier and the Khumbu Icefall.
Nature and Culture
The Everest Base Camp Trekking is a beautiful trek. This trek exhibits the beautiful nature and culture in the Everest region. Walk into varying landscapes, dense forests, riverbanks, and glacial moraines. You will have a wonderful time.
There are chances of witnessing several floral and fauna diversities. We will walk into the Sagarmatha National Park, a natural UNESCO World Heritage Site in Nepal.
During the trek, you will be walking through the Sherpa villages and Monasteries. You can see the prayer flags flapping in the wind almost everywhere. The Himalayan Sherpas, their lifestyles, cultures, and traditions are interesting.
Trek Difficulties During Everest Base Camp Trek 13 Days
Everest Base Camp trek is the highest altitude trek in Nepal. During the trek, you will trek to the base camp of Mt. Everest, 5380 meters. The highest point that you reach on the trek is at Kalapathar 5643 meters. Due to it’s higher altitudes, most of the EBC trekkers suffer from Altitude Sickness.
Watch out for the symptoms of altitude sickness. Cure it as soon as possible. Ignoring the symptoms can make the condition more serious.
Length of the Trek
The distance from Lukla to the Everest Base Camp is 62 kilometers. The trek route is not uniform. There are lots of ups and downs and it adds difficulty to the trek. There are various tough sections. Walking through glacial moraines and passes are very hard.
Also, trekking in such a remote area for long duration can be exhausting. There are some trekkers who feel exhausted due to the length, duration, and difficulty of the trek.
Weather and Temperature
The weather in the Himalayas is always varying. We cannot predict the weather to be perfect. Fair weather in Everest can change in no time. Get information on the weather conditions in the Everest region before you plan to trek.
Also, you must get appropriate gears for the time that you are trekking in.
Note: We have suggested the appropriate gears for Everest Base Camp Trek for all seasons. Check our article on the Packaging Lists for Everest Base Camp Trek.
Accommodation and Food
Everest Base Camp Trek is a teahouse trek. The number of teahouses en route gets lesser as we trek to the higher altitudes. In the peak seasons, there is a huge inrush of trekkers and climbers in the Everest region. So, you might have difficulty in finding a place for accommodation and food.
Some Tips for Everest Base Camp Trek 13 Days
- Prepare physically and mentally. You must be physically fit. The trek has some tough sections. A strong mentality always boosts you to trek further.
- Pack light, pack wise. Include all the essential trekking gear.
- Stay hydrated. You can carry your own refillable water bottle and some water purifying tablets. You can buy bottled water at some places in the trek routes but they are expensive.
- Slow and steady wins this race! Maintain your own pace of the walk. Make it constant. Do not try to overdo.
- Wear comfortable hiking boots. You will have to walk continuously for days. With an uncomfortable boot, you might get blisters on your feet.
- It’s chilly up there at the base camp. Get a down jacket and a warm sleeping bag for nights (any time of the year).
- If you are trekking in Monsoon, you need rain protection for all your gear.
- Make sure to be open. You cannot stay quite after you get any signs of altitude sickness. The situation can get worse while doing so.
Everest Base Camp trek 13 days is an amazing experience of trekking in the base of the world’s highest peak Mt. Everest and enjoying the best of the Everest region. This 13 days exotic trek takes you to the typical Sherpa settlements in the Himalayas.
For more details on this trek, contact us.
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https://excitingnepal.com/everest-base-camp-trek-13-days/
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An awesome song from one of the best praise leader in Nigeria. Lawrence & Decovenant has been a blessing to the body of Christ and this generation in general.
They have been touching lives with their inspirational lyrics and awesome voices. The song Testify talks about the goodness of God, what he has done and about to do.
Listen and be blessed.
Stream & download video here
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https://trinitymedia.com.ng/audio-video-testify-by-lawrence-decovenantfree-download-trinity-media/
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Kate Middleton has been credited with influencing more people than ever to join the Scouts, as membership reaches an all-time high.
Since the royal announced last January that she would become a volunteer for the organisation, total membership has risen by more than 11,500, reaching record levels.
Nearly 3000 adults have also signed up as volunteers in the last year, one of the biggest rises in decades for the organisation.
CLICK ON IMAGES TO VIEW GALLERY
The Duchess of Cambridge has been seen volunteering for the Scouts and last month proved herself to be a dab hand at breadmaking when she joined the scouts for an activity day in the Lake District.
The royal joked with other volunteers about her "twister" bread: "Oh it's actually not bad," she said. "If you were desperately hungry."
Kate has becoming one of the growing members of flexible volunteers who, because of other commitments, help when they can rather then every session.
At the time of becoming a volunteer, a St James's Palace spokesperson said she "loved the idea of Scouting and working hands-on with children".
Latest figures have shown that the total number of adults has passed 100,000 for the first time this century, showing that the Scouts may be the latest organisation to be charmed with the "Kate Effect".
Chief Scout Bear Grylls praised the mum-to-be's efforts: "It's great that so many adults are joining the Scouts, and I am sure the increase has had much to do with the Duchess of Cambridge becoming a Scout Volunteer last year."
"She is an incredible role model and she helps is show that Scouting's not just for boys
"She's also such a generous volunteer and everyone is excited to have her in the Scouting family".
On Sunday, Kate attended the National Review of the Queen's Scouts at Windsor Castle. The pregnant duchess spent time with excited well-wishers and guest from both the UK and the Commonwealth.
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https://www.hellomagazine.com/royalty/2013042512248/kate-middleton-scout-membership-rise/
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We all respond to stress differently. For some, it produces a panic of tail-chasing “what if” ideation or sets off a downward spiral of lethargic cynicism. For others, it leads to explosive overachievement, which doesn’t seem that bad until you run out of stuff to clean, cook, or organize. And for still others, stress is a trigger for serious disorders like anxiety, depression, addiction, and self-harm.
These are all side effects of the brain and body going into “emergency mode.” When your brain senses danger, it signals the body to shut down anything unnecessary, while turning up the senses to maximize your perception of where and whom the danger is coming from.
None of that would be so bad if we only experienced stress on an occasional basis. Our primal ancestors certainly got stressed out when they saw a wild animal stalking them, or when a lightning storm threatened to incinerate their village. But as we’re all too well aware, stress is a constant presence in our lives today.
Modern threats to survival have typically been more social in nature — we’re worried over whether a new shirt makes us look fat, or if we’re going to miss a deadline or flub an interview. Just because these threats don’t come with fangs or fire doesn’t make them easier to deal with. At its core, stress is always about the struggle to survive. When you take everyday concerns about financial security, future opportunities, the state of government and the economy, and the well-being of family and friends, and then add a new and frequently lethal virus into the mix, you’ve got a seriously debilitating load of stress.
That’s why we — you, me, us, everyone — need to start meditating right now.
Meditation helps with weathering the coronavirus lockdown for the same reason it helps with any type of stress — by giving your brain a chance to fix itself. According to neurological studies over the past decade, the synapses in our brain tend to favor the same pathways over and over. Just as you have your favorite route to take to work (you know, back when you used to work outside the home), your thoughts, ideas, and opinions tend to take the same route from the subconscious to the conscious brain. This process creates actual grooves in your brain that make it even easier to fall into the same patterns of thought. So if you have a groove that views a situation negatively, every new idea (even a positive one) is likely to be interpreted negatively by the time it reaches your conscious thought.
Meditation fixes this by flattening out those grooves, giving your ideas a chance to take the road less traveled by. In doing so, it’s been shown to help with things like gaining a new perspective on stressful situations; building skills to manage stress; focusing on the present; and increasing patience, tolerance, and imagination while reducing negative emotions and responses to stimuli.
- How to Meditate: A Guide for Beginners
- End the Stigma Around Men’s Mental Health
- A Complete Guide to Self-Care for Men
Needless to say, our current global situation makes meditation more important than it’s ever been. If you’re being a good citizen and abiding by shelter-in-place guidelines, your usual outlets and distractions aren’t available anymore. Without the freedom to go for a jog or meet up with friends at your favorite watering hole, how are you supposed to clear your head? And the distractions of TV, Internet, and takeout food you can only get you so far.
Meditation is just as important for essential workers, who are living at the other end of the spectrum. While the rest of us are just suffering from boredom and malaise, medical caregivers and other essential service providers are running a never-ending rat’s maze, trying to work an already overpacked schedule under the constant threat of contracting the virus from the people they serve. Believe it or not, meditation can help these people, as well.
It’s hard to believe something as simple as sitting still and thinking positive thoughts (or no thoughts at all) could help in such a complicated time as this. We’re here to tell you the proof is in the doing. Give meditation a try — just 5 to 10 minutes a day — and see if you don’t feel just a little bit better. It might not change the world, but it can at least change your world. And in challenging times like this, that’s not nothing.
Benefits of Meditation
Meditation helps heal physical issues
According to Harvard Health, when you’re under constant heavy stress, your adrenal glands overproduce the hormone cortisol. Too much cortisol in the system deals a serious blow to the function of your immune system, as well as the health of other organs in your body.
While you can’t always do much about the stress you’re under, meditation is here to help. By activating the parasympathetic nervous system, meditation helps your body rest, recover, and reset. By stopping the overflow of cortisol, your body is able to regulate breathing, bring down elevated blood pressure, restore normal organ function, and put the immune system back to work.
We’re not just saying this, either. A 2009 study on patients with heart health issues showed that those who practiced meditation once per day experienced over 40% fewer heart attacks and other “cardiovascular events.” Even more tellingly, 80% of the patients who participated in the study were still practicing meditation nine years later. But even if heart health isn’t your issue, you can still benefit from meditation’s beneficial impact on conditions like asthma, irritable bowel syndrome, tension headaches, and chronic pain.
Meditation helps you sleep
Much as we’re all enjoying those middle-of-the-night text threads with fellow quarantined insomniacs, we’d be better off getting good sleep during this time of high stress and uncertainty. Not only does daytime sleepiness sap your productivity (no good when you’re adjusting to working from home), but it also deteriorates your overall health and your mental and emotional resilience.
Fortunately, the same benefits of meditation listed above help overcome a racing mind and physical restlessness. By spending just ten minutes a day on a meditation practice that focuses on your breathing and brings your mind’s attention to the present, you can trigger a full-body relaxation response that gently ushers you into a deep, restorative sleep.
Meditation helps with anxiety, depression, and addiction
This should come as no surprise. Meditation has been studied for decades as a deterrent to those who struggle with behavioral disorders like anxiety, depression, and addiction. The idea is that meditation calms and reassures the “wanting mind,” which creates its own obstacles to well-being by being always on high alert for threats while reaching out for this perfect panacea that lies just beyond our grasp. In past years, that panacea might have been a romantic partner, a better job, or just getting the last word in with your snarky brother-in-law. But now, of course, it looks like taking that vacation you had to cancel, enjoying a two-hour meal in a restaurant full of happy people, or even just a hug from your mom.
Meditation is key to helping quell the wanting mind by restoring your focus on the here and now. And you may be saying, “The here and now is exactly what I’d like to avoid.” But the thing is, mindful grounding yourself in the present is actually the best way to exit the spiral of self-harmful behavior. By helping you be fully present in the moment (instead of worrying about the future or ruminating on the past), meditation helps you climb out of your brain’s habitual groove and see things in a more interesting and newly positive light. As a bonus, it increases your interleukin levels (providing you with greater energy) and triggers your body to release chemical toxins that affect neurotransmitter receptors and alter your mood.
Meditation helps with conflict management
Sartre’s immortal words “Hell is other people” are truer than they’ve ever been, thanks to this pandemic. Your roommates drive you crazy with every little cough or throat clearing. Your spouse’s mood swings are aggravating your own. Your kids, your pets, your neighbors, even your houseplants are making you wish that you could start life over as a hermit on top of a mountain. Of course, even if you lived there, there would still be the internet to fill your soul with rage at the cesspool that is humanity in 2020.
Deep breath. It’s okay to admit that shelter-in-place has you feeling (and acting) more … prickly, shall we say? We’re all feeling it, and meditation is here to help.
Our cultural assumption is that conflict is only resolved by the strongest argument. Make a better case than your opponent (or just shout louder than they can), and you’ve won. But in fact, researchers are finding that something called “relational agility” is actually more effective in resolving conflict. This skill involves working with everything that comes up in a human interaction, including elements that are felt rather than articulated. (For example, your roommate says it’s fine with them if you blast music while you clean out your closet, but you get the vibe that they are really not fine with it at all.)
By slowing down your thought process and tuning you into the sensations of the present moment, meditation can help you step outside your own ego-centered perspective to sense what’s important to the other person. In other words, it helps you develop compassion. And rather than interpreting their response negatively (there are those brain grooves again) as selfishness, rudeness, or pure crazy, it allows you to see their more vulnerable side — they feel just as afraid, uncertain, and flat-out bored as you do. Once you’ve made those relatable connections, it’s hard not to interact with more grace and patience, even in the midst of conflict.
Meditation helps you appreciate simple things
Remember when you used to wish you had more time to fill in the blank? Read poetry, cook elaborate meals, practice guitar, listen to the entire catalog of your favorite musician, etc.? Well, you’ve got it now — how is all that going for you?
If you’re like us, you might not have crossed many of these time investments off your bucket list, even after four or more weeks of shelter-in-place. Why? Because the fast-paced digitally influenced society we’ve been living in for the past 20 years has groomed our brains to have the attention span of a cocker spaniel on four shots of espresso. As a result, even now that we have all the time in the world to spend on things we love, we’re wasting that time the way we always do: Scrolling through our phone or complaining how there’s nothing to watch on Netflix.
Meditation is the key to making the most of this time. Much as we hate to be all Pollyanna, it’s undeniable that this is the quiet moment we’ve been waiting for all our lives, and as much as it sucks, why not make the most of the opportunity? It might never come again — we hope it doesn’t.
So dust off that record collection or that anthology of short stories, and before you dive in, spend 10 minutes meditating to get yourself in the right frame of mind to really soak it up.
Meditation makes you more creative
If you’re like me, you’re finding yourself running out of household projects that will use up your free time. If you’re saving the last bits of mold to clean out of the shower like a favorite imported wine, it’s time to turn your energy toward a more artistic endeavor. Meditation can help with that.
One of the fun discoveries from meditation research is that it works along very similar lines as taking a consciousness-enhancing drug, like psilocybin or LSD. After booting your brain out of its habitual grooves, meditation induces high-frequency brain waves associated with attention, perception, and divergent thinking, allowing you to notice and feel things in new and unusual ways. From there, it’s just a matter of applying those brain waves to the kernel of an idea. And if you tend to be a perfectionist, good news: Meditation also boosts your ability to bounce back from a failed attempt and even negative feedback from others.
This isn’t just for artists, poets, and musicians. Major corporations like Google, Goldman Sachs, and Medtronic have introduced meditation to their employees in hopes of spurring more creative thinking to get ahead in the marketplace. So even if you’re a firmly left-brain kind of guy, practicing meditation can supercharge your work-from-home productivity and — who knows? — position you for a serious professional promotion once life gets back to normal.
Meditation puts good vibes into a world that needs them badly
This is where it gets woo-woo, but just hang with me, okay? Sure, meditation improves your individual experience of the world, and that’s not nothing. But there are schools of thought, especially within traditional spiritual circles, that practicing a certain form of meditation known as “lovingkindness meditation” sends positive energy out into the world that can support our collective understanding, compassion, and cooperation. In other words, one person meditating for 10 minutes a day creates a ripple effect that improves the lives and experiences of people they’ll probably never meet.
There’s a lot of weird science around this, much of it having to do with the mysterious realm of quantum physics. But the central idea is that the collective consciousness of every living thing creates a unified field, like a medium that we all live in. Each action and thought contributes to that field, for good or for harm. For a good analogy, notice what happens to the overall temperature of your house if you open the door to a cold bedroom or closet. The unified field is like that; the “temperature” of one person’s mind-body-spirit feeds into the experience of the whole.
We get it, this one is a little bit out there. But right now, we could all use every bit of healing power and positivity available to us. So what’s the harm in putting some good intentions out there, even if they’re woo-woo? At worst, it’ll make you feel better for having done something good for yourself and for humanity.
- 10 Small DIY Projects You Can Tackle While Stuck at Home
- Self-Care for Men: A Complete Guide to Feeling Your Absolute Best
- 9 Reasons to Learn a Language While You’re Stuck at Home
- A Complete Guide to Meditation for Men
- End the Stigma and Start the Conversation About Men’s Mental Health
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https://www.themanual.com/culture/benefits-of-meditation-why-you-should-start-meditating/
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We have studied the capacitance-voltage (C- V) characteristics of Schottky barriers on inverted nGaAs/ N-AIGaAs and normal N-AIGaAs/n-GaAs heterojunctions. Impurities introduced during film growth produced a negative sheet charge of 6.0 X 10 II cm -2 at the interface of the inverted n-GaAs/N-AIGaAs heterojunction. The effectiveness of GaAs quantum wells in trapping these impurities was investigated. GaAs quantum wells 20 A wide were placed in intervals of 2500 A for the first 0.75 pm of the AIGaAs layer; in the last 0.25 pm, the periodicity of the quantum wells was progressively decreased by half with the last quantum well placed at about 160 A from the GaAs/ AIGaAs interface. The resulting measured interface charge concentration of 4.4 X 1010 cm -2 is more than a magnitude lower than measured before the use of the quantum wells and is essentially at the limit of the accuracy of the C-V technique for this structure.
Date of this Version
Appl. Phys. Lett. 48, 428 (1986)
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https://docs.lib.purdue.edu/ecepubs/76/
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Just when you think that merger and acquisition transaction numbers can’t get any higher, they keep breaking records. Fueled by near-zero interest rates, monetary stimulus, and investor demand for corporate debt, M&A showed the highest level of activity over the past nine months than at any time in the past four decades. Moreover, there’s zero sign of a slowdown: Grant Thornton’s recent survey found that 68% of M&A professionals expect deal volume to keep increasing.
If your organization is planning an M&A transaction in 2022 or any other time, you need to be ready to tell your story well and sell the deal to all stakeholders. Following are the critical points to keep in mind.
The rationale should be a few key messages that explain why the transaction is in the best interest of all stakeholders and will create value for shareholders. It should be presented in the context of the company’s stated strategy and value creation plans and consider the skeptic’s point of view.
One of the best ways to develop a compelling rationale is to think through the questions that will be asked on announcement day.
Once agreed on, the deal rationale should be consistently communicated in all deal-related communications materials (press releases, investor-call scripts, stakeholder letters, Q&As, and others).
One of the first things analysts and investors will do when seeing acquisition news is to search the web for information on the acquired company. Whether it’s a well-known public company or an unknown private one, the buyer needs to know what information investors and analysts might uncover on their own that will inform their impressions about the transaction as well as the questions they’ll ask. Do a thorough audit of all information in the public domain — from the company website to press articles and social media — and be especially alert for anything that might be negative, concerning, or inconsistent with your story.
The press release announcing the transaction is often the first opportunity to sell the deal to stakeholders. It should be considered an important forum to control the message with a compelling deal rationale. From an investor’s perspective, information reduces risk. Investors will want to understand how the acquisition will affect the company’s risk profile and financial performance, particularly how it will generate a return on invested capital. The release should have
That includes employees and customers of both companies, and the communication must begin on announcement day. The goal is to make sure important stakeholders hear the news directly from management rather than listening or reading about it from other sources.
Employees will want to know how their jobs will change due to the transaction. Top concerns will be any changes in their reporting structure, their responsibilities, compensation, benefits, stock options, potential layoffs, and new growth opportunities. Be careful to avoid any commitments that might be reversed (e.g., saying there will be no layoffs when, in fact, there may be some redundancies later). Remember, it’s OK to tell employees that it’s still early in the process, but management is committed to providing updated information as things progress. Finally, keep in mind that anything you send out to employees could quickly end up in the public domain.
Employees, especially the relationship managers, will need to be armed with talking points to ensure message continuity when fielding customer calls.
In an M&A transaction, customers don’t always think bigger is better. Instead, they will want to know that they are highly valued and it’s “business as usual” — they’ll get the same great products and service they’ve always received from your company, on the same terms, through the same people.
Employees, especially the relationship managers, will need to be armed with talking points to ensure message continuity when fielding customer calls. When there is a shortlist of large customers, it’s worth the effort to conduct proactive outreach via phone calls on announcement day.
A thoughtful media strategy can result in positive coverage. The deal announcement is the newsworthy event, not the deal close. The best way to enhance the odds of generating coverage for an M&A transaction from a major financial publication or broadcast outlet is to disclose the deal size and transaction terms and give the story to a trusted reporter as an exclusive. Some reporters are eager to get exclusives and are willing to cover small transactions if they are the only ones with the story. Once you’ve identified a reporter interested in an exclusive, brief the reporter before the announcement to ensure a complete understanding of the transaction and an accurate and positive story.
Successful M&A communications require planning and careful coordination at every step. Develop a detailed timeline for both the preparation process and announcement day. There are lots of questions to consider — do you want to have an investor call on announcement day? Do you want to create any additional communication channels — a microsite, video, or deal-at-a-glance fact sheet? How and when will communications go out to employees and customers? Are there other stakeholders to consider, such as critical vendors and partnerships? Logistics matter greatly when several stakeholders are involved. For example, the team must consider the different time zones involved and carefully manage material, nonpublic information.
Despite best efforts to communicate the merits of the deal and favorable reports from sell-side analysts, an acquirer’s stock often sells off immediately after news of an acquisition. There are many reasons for this — from merger arbitrage activity (buying the target and shorting the acquirer) to a long history of acquisitions that didn’t work out and resulted in massive goodwill write-downs. So, keep in mind that this is just an initial reaction and remember the words of Benjamin Graham, the father of fundamental security analysis: In the short run, the stock market is a voting machine, but in the long run, the stock market is a weighing machine. So, don’t worry too much if the votes aren’t cast in your favor on announcement day. Suppose future results show that the acquisition did indeed have the projected positive impact on earnings, cash flow, and other gauges of performance. In that case, the weighing machine will ultimately take control and reward the buyer for creating shareholder value.
Moira Conlon is the founder and president of Financial Profiles.
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https://www.cfo.com/credit-capital/mergers-acquisitions/2021/12/7-keys-to-communicating-an-ma-deal-effectively/
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I’ve felt apprehensive about writing on this topic and have thus prevented it for a while. For many individuals, the point of “getting serious” is to settle down and start constructing a life that can produce youngsters. It seemed like I used to be constantly destroying the relationships I used to be in and solely relationship needy girls. Even if God labored that means (which He doesn’t), you’ll have plenty of alternatives to trust God — and to be taught to love like Christ ( Ephesians 5:25 ) — in marriage, whether or not it is to this lady or someone else.
For those who ever need to take some of the load off, I’d absolutely love to jot down some articles on your weblog in alternate for a hyperlink again to mine. By embodying what respect means, companions can inspire one another, associates, and household to additionally behave in a respectful manner.
When people on the earth expect much less and fewer of each other in courting, God is not. The world’s approach can present enjoyable and intercourse and youngsters and finally even some stage of dedication, but it cannot result in the life-giving Jesus after whom our marriages are to take their cues.
Having a dating associate felt happier than any defined relationship I’d had in years. Reddit users who weighed in on the subject have been keen to elucidate the difference between casual courting versus relationships primarily based on their own experiences.
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http://www.echu.org/relationship-consultation-for-artistic-professionals-3.html
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This stylish coral cushion is on trend and the perfect cushion for your home or seaside retreat.
Match back with its coordinating throws to complete the look for your home.
Designed and produced in Austria
85% cotton, 8% viscose, 7% acrylic
Size 50 x 50 cm
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https://www.emotionandkids.com.au/blue-coral-nova-50x50-cushion
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Noro Silk Garden Solo is similar to Noro's Silk Garden except with more subtle colorings. Like Silk Garden, Silk Garden Solo is an Aran weight mohair silk and lambswool blend. Projects with this yarn include hats, mitts, and slippers.
45% Silk, 45% Mohair, 10% WooI with approx 110 yards per 50g that knits to 4.5 sts per inch on a US 8.0 needle.
Packaged as skeins.
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https://www.knit-n-crochet.com/Noro-silk-garden-solo.html
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