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ec86b206c2c40e6126b553193ab5b27c51911adb1430f3a6b9fbd75b39d930f8
NEURON
419
30
NEURON { POINT_PROCESS inject_norm_concentration USEION x WRITE xd RANGE alpha, beta } ASSIGNED { beta volume } PARAMETER { alpha = 200 area diam } INITIAL { beta = 0 volume = area*diam/4 : = pi*r^2*h } BREAKPOINT { xd = xd + beta * area / 1000 / volume : considering particle concentration -...
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NEURON
425
36
NEURON { SUFFIX test1_kin_compartment } STATE { s d h } PARAMETER { A = 0.5 } BREAKPOINT { SOLVE state METHOD sparse } KINETIC state { COMPARTMENT A {s h d} LOCAL alpha1, beta1, alpha2, beta2 alpha1 = 2 beta1 = 0.6 alpha2 = 3 beta2 = 0.7 ~ s <-> h (alpha1, beta1) ~ ...
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NEURON
425
38
NEURON { POINT_PROCESS expsyn RANGE tau, e NONSPECIFIC_CURRENT i } UNITS { (mV) = (millivolt) (uS) = (microsiemens) } PARAMETER { tau = 2.0 (ms) : the default for Neuron is 0.1 e = 0 (mV) } ASSIGNED {} STATE { g (uS) } INITIAL { g = 0 } BREAKPOINT { SOLVE state METHOD cne...
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NEURON
429
36
NEURON { SUFFIX test0_kin_compartment } STATE { s d h } PARAMETER { A = 0.5 B = 0.1 } BREAKPOINT { SOLVE state METHOD sparse } KINETIC state { COMPARTMENT A {s h} COMPARTMENT B {d} LOCAL alpha1, beta1, alpha2, beta2 alpha1 = 2 beta1 = 0.6 alpha2 = 3 beta2 = 0.7 ...
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NEURON
475
39
NEURON { SUFFIX test1_kin_steadystate } STATE { a b x y } PARAMETER { A = 0.5 B = 0.1 } BREAKPOINT { SOLVE state STEADYSTATE sparse } KINETIC state { COMPARTMENT A {a b} LOCAL alpha1, beta1, alpha2, beta2 alpha1 = 2 beta1 = 0.6 alpha2 = 3 beta2 = 0.7 ~ a <-> b (alph...
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NEURON
506
23
NEURON { SUFFIX neuron_with_diffusion USEION s READ sd } PARAMETER { area : surface area of the CV (in µm^2, internal variable) diam : CV diameter (in µm, internal variable) } ASSIGNED { volume : volume of the CV (conversion factor between concentration and particle amount, in µm^3) sV : particle amount in the ...
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NEURON
545
47
: Delta synapse without plasticity NEURON { POINT_PROCESS deltasyn RANGE g_spike NONSPECIFIC_CURRENT I } UNITS { (ms) = (milliseconds) (mV) = (millivolt) } PARAMETER { g_spike = 1 (mV) : increase in g through one spike } ASSIGNED { } STATE { g (mV) : instantaneous synaptic conductance (non-zero if there a s...
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NEURON
565
39
: Based on Kd model of Foust et al. (2011) NEURON { SUFFIX Kd USEION k READ ek WRITE ik RANGE gbar } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gbar = 0.00001 (S/cm2) } STATE { m h } BREAKPOINT { SOLVE states METHOD cnexp LOCAL g g = gbar*m*h ik = g...
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NEURON
574
38
: Example of mechanism that updates the concentration of an ionic species. NEURON { SUFFIX test_ca USEION ca READ ica WRITE cai VALENCE 2 } UNITS { (mV) = (millivolt) (mA) = (milliamp) (molar) = (1/liter) (mM) = (millimolar) (um) = (micron) } PARAMETER { decay = 80 (ms) : decay rate ...
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NEURON
583
43
NEURON { POINT_PROCESS exp2syn RANGE tau1, tau2, e NONSPECIFIC_CURRENT i } UNITS { (mV) = (millivolt) } PARAMETER { tau1 = 0.5 (ms) tau2 = 2 (ms) e = 0 (mV) } ASSIGNED { factor } STATE { A B } INITIAL { LOCAL tp A = 0 B = 0 tp = (tau1*tau2)/(tau2 - tau1) * log(tau...
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NEURON
609
37
NEURON { POINT_PROCESS template RANGE xp, yp, zp, xd, yd, zd NONSPECIFIC_CURRENT i } PARAMETER { field xp yp zp : proximal coordinates xd yd zd : distal coordinates r_axial : axial resistivity } ASSIGNED { da } STATE {} INITIAL { LOCAL dx, dy, dz : vector spanned by segment ...
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NEURON
615
40
: Comment: Kv3-like potassium current NEURON { SUFFIX Kv3_1 USEION k READ ek WRITE ik RANGE gbar } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gbar = 0.00001 (S/cm2) vshift = 0 (mV) } STATE { m } BREAKPOINT { SOLVE states METHOD cnexp ...
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NEURON
630
30
: Compute reversal potential for generic ion using Nernst equation. : : TODO: support global derived parameters via e.g. GLOBAL + ASSIGNED, : so that we don't need to store a copy of coeff at every CV. NEURON { SUFFIX nernst USEION x READ xi, xo WRITE ex VALENCE zx GLOBAL R, F RANGE coeff } PARAMETER ...
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NEURON
634
38
: Ornstein-Uhlenbeck: linear mean reverting process : ================================================= : dS(t) = kappa [mu - S(t)] dt + sigma dW(t) : E[S(t)] = mu - (mu-S_0)*e^(-kappa t) : Var[S(t)] = sigma^2/(2 kappa) [1 - e^(-2 kappa t)] : in the limit: : lim t->∞ E[S(t)] = mu : lim t->∞ Var[S(t)] = ...
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NEURON
639
23
//register APs in each GC objref BCAP[BC_number], BCAP_time[BC_number] objref GCAPrecord[GC_number] objref GCAP_time[GC_number] //record the time of individual APs in each GC proc RegisterAP(){ local a for a=0, GC_number-1 {access GC[a].soma GCAPrecord[a]=new APCount(0.5) GCAPrecord[a].thresh...
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NEURON
650
42
: Stochastic Volatility (linear SDE) : =================================== : P: log of the price (of a stock or bond) : sigma: volatility : The observed volatility of the price is not constant but itself a stochastic process. NEURON { POINT_PROCESS stochastic_volatility GLOBAL mu, theta, kappa, sigma_1 } ...
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NEURON
657
45
: SK-type calcium-activated potassium current : Reference : Kohler et al. 1996 NEURON { SUFFIX SK_E2 USEION k READ ek WRITE ik USEION ca READ cai RANGE gSK_E2bar } UNITS { (mV) = (millivolt) (mA) = (milliamp) (mM) = (milli/liter) } PARAMETER { gSK_E2bar = 0.000001 (mho/cm2) zTau ...
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NEURON
665
50
UNITS { (mV) = (millivolt) (S) = (siemens) } NEURON { SUFFIX pas NONSPECIFIC_CURRENT i RANGE g, e } INITIAL {} PARAMETER { g = .001 (S/cm2) e = -65 (mV) : we use -65 for the ball and stick model, instead of Neuron default of -70 v (mV) } STATE { s } BREAKPOINT { foo(i) } PROCED...
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NEURON
670
43
:Reference Characterization of a Shaw-related potassium channel family in rat brain, The EMBO Journal, vol.11, no.7,2473-2486 (1992) NEURON { SUFFIX SKv3_1 USEION k READ ek WRITE ik RANGE gSKv3_1bar } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gSKv3_1b...
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NEURON
683
46
: Exponential current-based synapse NEURON { POINT_PROCESS expsyn_curr RANGE w, tau, R_mem NONSPECIFIC_CURRENT I } UNITS { (ms) = (milliseconds) (mV) = (millivolt) (MOhm) = (megaohm) } PARAMETER { R_mem = 10.0 (MOhm) : membrane resistance tau = 5.0 (ms) : synaptic time constant w = 4.20075 (mV) : weight } ...
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NEURON
695
42
: Mean reverting process (linear SDE) : =================================== : dS(t) = kappa [mu - S(t)] dt + sigma dW(t) : If mu==0 it is called Ornstein-Uhlenbeck process : E[S(t)] = mu - (mu-S_0)*e^(-kappa t) : Var[S(t)] = sigma^2/(2 kappa) [1 - e^(-2 kappa t)] : in the limit: : lim t->∞ E[S(t)] = mu : ...
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NEURON
697
43
: SK-type calcium-activated potassium current : Reference : Kohler et al. 1996 NEURON { SUFFIX SK USEION k READ ek WRITE ik USEION ca READ cai RANGE gbar } UNITS { (mV) = (millivolt) (mA) = (milliamp) (mM) = (milli/liter) } PARAMETER { gbar = .000001 (mho/cm2) zTau = 1 (ms) ...
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NEURON
743
42
NEURON { POINT_PROCESS efield RANGE xp, yp, zp, xd, yd, zd NONSPECIFIC_CURRENT i } PARAMETER { xp yp zp : proximal coordinates xd yd zd : distal coordinates e0 : amplitude omega : frequency r_axial : axial resistivity } ASSIGNED { da } STATE { t } INITIAL { LOCAL dx...
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NEURON
752
55
:Comment : :Reference : : Characterization of a Shaw-related potassium channel family in rat brain, The EMBO Journal, vol.11, no.7,2473-2486 (1992) NEURON { SUFFIX SKv3_1 USEION k READ ek WRITE ik RANGE gSKv3_1bar, gSKv3_1, ik } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gSKv...
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NEURON
768
53
: Reference: Kole,Hallermann,and Stuart, J. Neurosci. 2006 NEURON { SUFFIX Ih NONSPECIFIC_CURRENT ihcn RANGE gIhbar } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gIhbar = 0.00001 (S/cm2) ehcn = -45.0 (mV) } STATE { m } BREAKPOINT { SOL...
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NEURON
800
39
COMMENT Author: Aaron Miller Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig Germany -- Point process which computes membrane current (nonspecific current) as a result of a user provided conductance timeseries. Based on a conductance-based synapse, the user specifies the refersal potential 'e', the...
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NEURON
824
47
: Reference: Kole, Hallermann, and Stuart : J. Neurosci. 2006 NEURON { SUFFIX Ih NONSPECIFIC_CURRENT ihcn RANGE gbar } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gbar = 0.00001 (S/cm2) ehcn = -45.0 (mV) } STATE { m } BREAKPOINT { ...
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NEURON
842
68
NEURON { SUFFIX test_inilining } UNITS { (mV) = (millivolt) (S) = (siemens) } PARAMETER { alpha = 2 beta = 4.5 gamma = -15 delta = -0.2 } STATE { s0 s1 s2 } BREAKPOINT { s1 = foo(alpha, beta) rates(delta) s0 = s1 * s2 } FUNCTION iden(x) { iden = x } FUNCTION...
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NEURON
874
41
: Dynamics that track inside calcium concentration : modified from Destexhe et al. 1994 NEURON { SUFFIX CaDynamics_E2 USEION ca READ ica WRITE cai RANGE decay, gamma, minCai, depth, initCai } UNITS { (mV) = (millivolt) (mA) = (milliamp) (molar) = (1/liter) (mM) = (millimolar) (um) ...
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NEURON
883
62
:Reference : : Adams et al. 1982 - M-currents and other potassium currents in bullfrog sympathetic neurones :Comment: corrected rates using q10 = 2.3, target temperature 34, orginal 21 NEURON { SUFFIX Im USEION k READ ek WRITE ik RANGE gImbar, gIm, ik } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (millia...
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NEURON
887
48
: Based on Im model of Vervaeke et al. (2006) NEURON { SUFFIX Im_v2 USEION k READ ek WRITE ik RANGE gbar, qt } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { celsius (degC) gbar = 0.00001 (S/cm2) } ASSIGNED { qt } STATE { m } BREAKPOINT { SO...
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NEURON
890
50
: Reference: M-currents and other potassium currents in bullfrog sympathetic neurones : Adams et al. 1982 : Comment: corrected rates using q10 = 2.3, target temperature 34, orginal 21 NEURON { SUFFIX Im USEION k READ ek WRITE ik RANGE gbar, qt } UNITS { (S) = (siemens) (mV) = (milliv...
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NEURON
892
39
: Dynamics that track inside calcium concentration : modified from Destexhe et al. 1994 NEURON { SUFFIX CaDynamics USEION ca READ ica WRITE cai RANGE decay, gamma, minCai, depth GLOBAL F } UNITS { (mV) = (millivolt) (mA) = (milliamp) (molar) = (1/liter) (mM) = (millimolar) ...
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NEURON
899
57
TITLE K-DR : K-DR current for Mitral Cells from Wang et al (1996) : M.Migliore Jan. 2002 : ek (mV) must be explicitly def. in hoc : ik (mA/cm2) NEURON { THREADSAFE SUFFIX kdrmt USEION k READ ek WRITE ik RANGE gbar, vhalfm } PARAMETER { v(mV) celsius gbar = 0.002 (mho/cm2) a0m...
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NEURON
902
54
: Reference: Adams et al. 1982 - M-currents and other potassium currents in bullfrog sympathetic neurones : Comment: corrected rates using q10 = 2.3, target temperature 34, orginal 21 NEURON { SUFFIX Im USEION k READ ek WRITE ik RANGE gImbar } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) ...
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NEURON
904
47
:Reference : Modeled according to kinetics derived from Magistretti & Alonso 1999 :Comment: corrected rates using q10 = 2.3, target temperature 34, orginal 21 NEURON { SUFFIX Nap RANGE gbar, qt USEION na READ ena WRITE ina } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gb...
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NEURON
905
54
: Reference: Adams et al. 1982 - M-currents and other potassium currents in bullfrog sympathetic neurones : Comment: corrected rates using q10 = 2.3, target temperature 34, orginal 21 NEURON { SUFFIX dummy USEION k READ ek WRITE ik RANGE gImbar } UNITS { (S) = (siemens) (mV) = (millivolt) (m...
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NEURON
913
36
: Dynamics that track inside calcium concentration : modified from Destexhe et al. 1994 NEURON { SUFFIX CaDynamics_E2 USEION ca READ ica WRITE cai RANGE decay, gamma, minCai, depth } UNITS { (mV) = (millivolt) (mA) = (milliamp) FARA...
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NEURON
976
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TITLE K-D : K-D current for prefrontal cortical neuron ------Yuguo Yu 2007 NEURON { THREADSAFE SUFFIX KdShu2007 USEION k WRITE ik RANGE gkbar, ik, ek GLOBAL minf, mtau, hinf, htau } PARAMETER { gkbar = 0.1 (mho/cm2) celsius ek = -100 (mV) : must be explicitly def. in hoc v (mV...
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NEURON
1,020
53
: $Id: xtra.mod,v 1.4 2014/08/18 23:15:25 ted Exp ted $ NEURON { SUFFIX xtra RANGE es : (es = max amplitude of the potential) RANGE Ex,Ey,Ez RANGE Dx,Dy,Dz RANGE x, y, z, type, order GLOBAL stim : (stim = normalized waveform) POINTER ex } PARAMETER { : default transfer resistance between stim electrodes and...
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NEURON
1,023
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:Comment LVA ca channel. Note: mtau is an approximation from the plots :Reference Avery and Johnston 1996, tau from Randall 1997 :Comment shifted by -10 mv to correct for junction potential :Comment corrected rates using q10 = 2.3, target temperature 34, orginal 21 NEURON { SUFFIX Ca_LVAst USEION ca READ e...
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NEURON
1,037
53
: Comment: LVA ca channel. : Note: : - mtau is an approximation from the plots : - shifted by -10 mv to correct for junction potential : - corrected rates using q10 = 2.3, target temperature 34, orginal 21 : Reference: Avery and Johnston 1996, tau from Randall 1997 NEURON { SUFF...
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NEURON
1,065
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: Reference: Reuveni, Friedman, Amitai, and Gutnick, J.Neurosci. 1993 NEURON { SUFFIX Ca_HVA USEION ca READ eca WRITE ica RANGE gCa_HVAbar } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gCa_HVAbar = 0.00001 (S/cm2) } STATE { m h } BREAKPOINT { SOLVE stat...
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NEURON
1,090
57
NEURON { SUFFIX Nap_Et2 USEION na READ ena WRITE ina RANGE gNap_Et2bar } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gNap_Et2bar = 0.00001 (S/cm2) } STATE { m h } BREAKPOINT { SOLVE states METHOD cnexp ina = gNap_Et2bar*m*m*m*h*(v - ena) } ...
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NEURON
1,105
55
: Comment The transient component of the K current : Reference Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats:subtypes and gradients,Korngreen and Sakmann, J. Physiology, 2000 : Comment: shifted -10 mv to correct for junction potential : Comment corrected rates using q10 = ...
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NEURON
1,112
57
: SK-type calcium-activated potassium current : Reference : Kohler et al. 1996 NEURON { SUFFIX SK_E2 USEION k READ ek WRITE ik USEION ca READ cai RANGE gSK_E2bar, gSK_E2, ik } UNITS { (mV) = (millivolt) (mA) = (milliamp) (mM) = (m...
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NEURON
1,113
55
:Comment : :Reference : : Characterization of a Shaw-related potassium channel family in rat brain, The EMBO Journal, vol.11, no.7,2473-2486 (1992) NEURON { SUFFIX SKv3_1 USEION k READ ek WRITE ik RANGE gSKv3_1bar, gSKv3_1, ik } UNITS { (S) ...
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NEURON
1,126
69
NEURON { SUFFIX NaTa_t USEION na READ ena WRITE ina RANGE gNaTa_tbar } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gNaTa_tbar = 0.00001 (S/cm2) } STATE { m h } BREAKPOINT { SOLVE states METHOD cnexp ina = gNaTa_tbar*m*m*m*h*(v-ena) } DERI...
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NEURON
1,128
57
: Reference: Reuveni, Friedman, Amitai, and Gutnick, : J. Neurosci. 1993 NEURON { SUFFIX Ca_HVA USEION ca READ eca WRITE ica RANGE gbar } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gbar = 0.00001 (S/cm2) } STATE { m h } BREAKPOINT { SOLVE s...
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NEURON
1,136
69
:Comment : LVA ca channel. Note: mtau is an approximation from the plots :Reference : : Avery and Johnston 1996, tau from Randall 1997 :Comment: shifted by -10 mv to correct for junction potential :Comment: corrected rates using q10 = 2.3, target temperature 34, orginal 21 NEURON { SUFFIX Ca_LVAst USEION ca READ ec...
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NEURON
1,138
68
:Comment : The transient component of the K current :Reference : : Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats:subtypes and gradients,Korngreen and Sakmann, J. Physiology, 2000 :Comment : shifted -10 mv to correct for junction potential :Comment: corrected rates using q10 = 2.3,...
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NEURON
1,141
79
:Reference :Colbert and Pan 2002 NEURON { SUFFIX NaTa_t USEION na READ ena WRITE ina RANGE gNaTa_tbar, gNaTa_t, ina, mtau_scale, htau_scale } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gNaTa_tbar = 0.00001 (S/cm2) } ASSIGNED { v (mV) ena (mV) ina (mA/cm2) gNaTa_t (S/cm2) ...
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NEURON
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: Comment: The transient component of the K current : Reference: Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats:subtypes and gradients : Korngreen and Sakmann, : J. Physiology, 2000 NEURON { SUFFIX K_T USEION k READ ek WRITE ik RANGE gbar, qt, vs...
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NEURON
1,167
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:Comment : :Reference : : Kole,Hallermann,and Stuart, J. Neurosci. 2006 NEURON { SUFFIX Ih NONSPECIFIC_CURRENT ihcn RANGE gIhbar, gIh, ihcn } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PAR...
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NEURON
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:Reference :Colbert and Pan 2002 :comment: took the NaTa and shifted both activation/inactivation by 6 mv NEURON { SUFFIX NaTs2_t USEION na READ ena WRITE ina RANGE gNaTs2_tbar, gNaTs2_t, ina } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gNaTs2_tbar = 0.00001 (S/cm2) } ASSIGNED...
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NEURON
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NEURON { SUFFIX hh05 USEION k READ ek WRITE ik NONSPECIFIC_CURRENT il : qt is ASSIGNED, but needs to be RANGE RANGE gl, el, gkbar, q10 } ASSIGNED { q10 } STATE { n } PARAMETER { gkbar = 0.036 (S/cm2) gl = 0.0003 (S/cm2) el = -54.3 (mV) celsius (degC) ...
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NEURON
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:Comment The persistent component of the K current :Reference Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats:subtypes and gradients,Korngreen and Sakmann, J. Physiology, 2000 :Comment shifted -10 mv to correct for junction potential :Comment corrected rates using q10 = 2.3...
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NEURON
1,212
65
TITLE K-A : K-A current for Mitral Cells from Wang et al (1996) : M.Migliore Jan. 2002 : ek must be explicitly set in hoc : ik has units (mA/cm2) NEURON { SUFFIX kamt USEION k READ ek WRITE ik RANGE gbar } PARAMETER { celsius v (mV) gbar = 0.002 (mho/cm2) a0m = 0.04 vhalfm...
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NEURON
1,240
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: Reference Colbert and Pan 2002 : Comment took the NaTa and shifted both activation/inactivation by 6 mv NEURON { SUFFIX NaTs2_t USEION na READ ena WRITE ina RANGE gNaTs2_tbar } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gNaTs2_tbar = 0.00001 (S/cm2) } ...
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NEURON
1,243
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: Exponential synapse with online STDP : cf. https://brian2.readthedocs.io/en/stable/resources/tutorials/2-intro-to-brian-synapses.html#more-complex-synapse-models-stdp NEURON { POINT_PROCESS expsyn_stdp RANGE tau, taupre, taupost, e, Apost, Apre, max_weight NONSPECIFIC_CURRENT i } UNITS { (mV) = (mil...
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NEURON
1,246
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NEURON { SUFFIX hh04 : a variable can be READ *or* WRITE, the latter granting read and write access USEION k READ ek WRITE ik NONSPECIFIC_CURRENT il : Note, no RANGE for STATE (these are implicitly unique to each CV) : gkbar is a new PARAMETER RANGE gl, el, gkbar } STATE { n } PARAMETER { ...
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NEURON
1,251
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: Comment: The persistent component of the K current : Reference: Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats:subtypes and gradients : Korngreen and Sakmann : J. Physiology, 2000 NEURON { SUFFIX K_P USEION k READ ek WRITE ik RANGE gbar, vshift...
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NEURON
1,251
73
:Comment : The persistent component of the K current :Reference : : Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats:subtypes and gradients,Korngreen and Sakmann, J. Physiology, 2000 :Comment : shifted -10 mv to correct for junction potential :Comment: corrected rates using q10 = 2.3...
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NEURON
1,253
61
:Reference : : Adams et al. 1982 - M-currents and other potassium currents in bullfrog sympathetic neurones :Comment: corrected rates using q10 = 2.3, target temperature 34, orginal 21 NEURON { SUFFIX Im USEION k READ ek WRITE ik RANGE gImbar, gIm, ik } ...
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NEURON
1,255
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NEURON { SUFFIX protein_synthesis RANGE theta, alpha, area USEION pc_ WRITE pc_d : common pool of plasticity-related proteins USEION sps_ READ sps_d : signal triggering protein synthesis } PARAMETER { theta = 1 : threshold for protein synthesis (refers to SPS concentration, in µmol/l or mmol/l or...
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NEURON
1,265
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TITLE K-DR channel : from Klee Ficker and Heinemann : modified to account for Dax et al. : M.Migliore 1997 UNITS { (mA) = (milliamp) (mV) = (millivolt) } PARAMETER { v (mV) ek (mV) : must be explicitely def. in hoc celsius (degC) gkdrbar=.003 (mho/cm2) vhalfn=13 (mV) a0n=0.02 (/...
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NEURON
1,307
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: Reference: Colbert and Pan 2002 NEURON { SUFFIX NaTs USEION na READ ena WRITE ina RANGE gbar, qt } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gbar = 0.00001 (S/cm2) malphaF = 0.182 mbetaF = 0.124 mvhalf = -40 (mV) mk ...
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NEURON
1,379
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: Kv2-like channel : Adapted from model implemented in Keren et al. 2005 : Adjusted parameters to be similar to guangxitoxin-sensitive current in mouse CA1 pyramids from Liu and Bean 2014 NEURON { SUFFIX Kv2like USEION k READ ek WRITE ik RANGE gbar, qt } UNITS { (S) = (siemens) (mV) = (millivolt) (...
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NEURON
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COMMENT Author: Aaron Miller Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig Germany -- Point process which computes membrane current (nonspecific current) as a result of a user provided conductance timeseries for a voltage gated NMDA synapse. Based on a conductance-based synapse, the user specifie...
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NEURON
1,392
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: Reference: Colbert and Pan 2002 NEURON { SUFFIX NaTa USEION na READ ena WRITE ina RANGE gbar, qt } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { v (mV) celsius (degC) gbar = 0.00001 (S/cm2) malphaF = 0.182 ...
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NEURON
1,442
72
:Comment : :Reference : : Reuveni, Friedman, Amitai, and Gutnick, J.Neurosci. 1993 NEURON { SUFFIX Ca USEION ca READ eca WRITE ica RANGE gCabar, gCa, ica } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) ...
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NEURON
1,458
85
:Comment : mtau deduced from text (said to be 6 times faster than for NaTa) :Comment : so I used the equations from NaT and multiplied by 6 :Reference : Modeled according to kinetics derived from Magistretti & Alonso 1999 :Comment: corrected rates using q10 = 2.3, target temperature 34, orginal 21 NEURON { SUFFIX Nap...
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NEURON
1,462
72
:Comment : :Reference : : Reuveni, Friedman, Amitai, and Gutnick, J.Neurosci. 1993 NEURON { SUFFIX Ca_HVA USEION ca READ eca WRITE ica RANGE gCa_HVAbar, gCa_HVA, ica } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (millia...
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NEURON
1,470
76
: Adaption of T-type calcium channel from Wang, X. J. et al. 1991; : c.f. NMODL file in ModelDB: : https://senselab.med.yale.edu/modeldb/showModel.cshtml?model=53893 : : Note the temperature rate correction factors of 5 (for m) and 3 : (for h <-> s <-> d) have been applied to match the model described : in the current-...
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NEURON
1,547
76
scale_factor = 0.1 //the scale factor for EPSGs in both BCs and GCs tstop=200 /* xopen("GC_connection_Poisson_excitation_231229_mpi.hoc") xopen("BC_excitatory_connection_231229_mpi.hoc") xopen("BC-GC_inhibitory_synapse_231229.hoc") */ xopen("GC_BC template_231229.hoc") objref GC GC=new excitatory_cell() geo...
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NEURON
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/* Copyright (c) 2015 EPFL-BBP, All rights reserved. THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS'' AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJ...
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NEURON
1,557
68
:Comment : LVA ca channel. Note: mtau is an approximation from the plots :Reference : : Avery and Johnston 1996, tau from Randall 1997 :Comment: shifted by -10 mv to correct for junction potential :Comment: corrected rates using q10 = 2.3, target temperature 34, orginal 21 NEURON...
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NEURON
1,560
68
:Comment : The transient component of the K current :Reference : : Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats:subtypes and gradients,Korngreen and Sakmann, J. Physiology, 2000 :Comment : shifted -10 mv to correct for junction potential :Comment: co...
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NEURON
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/* // Copyright (c) 2015 EPFL-BBP, All rights reserved. THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS'' AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN P...
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NEURON
1,568
79
:Reference :Colbert and Pan 2002 NEURON { SUFFIX NaTa_t USEION na READ ena WRITE ina RANGE gNaTa_tbar, gNaTa_t, ina } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) } PARAMETER { gNaTa_tbar = 0.0000...
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NEURON
1,569
44
/* Copyright (c) 2015 EPFL-BBP, All rights reserved. THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS'' AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJ...
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NEURON
1,570
44
/* Copyright (c) 2015 EPFL-BBP, All rights reserved. THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS'' AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJ...
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NEURON
1,572
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/* Copyright (c) 2015 EPFL-BBP, All rights reserved. THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS'' AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJ...
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NEURON
1,572
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/* Copyright (c) 2015 EPFL-BBP, All rights reserved. THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS'' AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJ...
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NEURON
1,572
44
/* Copyright (c) 2015 EPFL-BBP, All rights reserved. THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS'' AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJ...
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NEURON
1,575
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/* Copyright (c) 2015 EPFL-BBP, All rights reserved. THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS'' AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJ...
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NEURON
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/* Copyright (c) 2015 EPFL-BBP, All rights reserved. THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS'' AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJ...
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NEURON
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: Input current modeled by an Ornstein-Uhlenbeck process : Sets non-specific current given mean, volatility and relaxation time : : Adapted from Jannik Luboeinski's example here: https://github.com/jlubo/arbor_ou_lif_example : : I_ou input current (nA) : μ input current mean (nA) : σ input current volatility (...
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NEURON
1,604
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/* Copyright (c) 2015 EPFL-BBP, All rights reserved. THIS SOFTWARE IS PROVIDED BY THE BLUE BRAIN PROJECT ``AS IS'' AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE BLUE BRAIN PROJ...
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NEURON
1,656
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:Reference :Colbert and Pan 2002 :comment: took the NaTa and shifted both activation/inactivation by 6 mv NEURON { SUFFIX NaTs2_t USEION na READ ena WRITE ina RANGE gNaTs2_tbar, gNaTs2_t, ina } UNITS { (S) = (siemens) (mV) = (millivolt) ...
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NEURON
1,665
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:Comment : The persistent component of the K current :Reference : : Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats:subtypes and gradients,Korngreen and Sakmann, J. Physiology, 2000 :Comment : shifted -10 mv to correct for junction potential :Comment: c...
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NEURON
1,685
79
COMMENT Two state kinetic scheme synapse described by rise time tau1, and decay time constant tau2. The normalized peak condunductance is 1. Decay time MUST be greater than rise time. The solution of A->G->bath with rate constants 1/tau1 and 1/tau2 is A = a*exp(-t/tau1) and G = a*tau2/(tau2-tau1)*(-exp(-t/tau1) + e...
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NEURON
1,702
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: sample file ? another style of comments NEURON { THREADSAFE SUFFIX test USEION ca READ cai USEION k WRITE ik READ ki RANGE gkbar, ik, ek, ki, cai GLOBAL minf, mtau, hinf, htau } STATE { h (nA) m r } UNITS { (S) = (siemens) (mV) = (millivolt) (mA) = (milliamp) (mo...
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NEURON
1,761
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COMMENT Two state kinetic scheme synapse described by rise time tau1, and decay time constant tau2. The normalized peak conductance is 1. Decay time MUST be greater than rise time. The solution of A->G->bath with rate constants 1/tau1 and 1/tau2 is A = a*exp(-t/tau1) and G = a*tau2/(tau2-tau1)*(-exp(-t/tau1) ...
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NEURON
1,816
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objref PC, PCvode PC= new ParallelContext() PC.nthread(256) dt=.1 //PC.runworker() RNGseed=31123 number_of_axon=2500 //2500 axons, producing a connection probability of 2% (Scharfman, 2009) input_sample_size = 50 //how many axons each GC sample from number_of_input=25 //each axon produce 75 inputs that are distributed...
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NEURON
1,816
69
objref PC, PCvode PC= new ParallelContext() PC.nthread(256) dt=.1 //PC.runworker() RNGseed=31123 number_of_axon=2500 //2500 axons, producing a connection probability of 2% (Scharfman, 2009) input_sample_size = 50 //how many axons each GC sample from number_of_input=25 //each axon produce 75 inputs that are distributed...
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NEURON
1,816
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objref PC, PCvode PC= new ParallelContext() PC.nthread(256) dt=.1 //PC.runworker() RNGseed=31123 number_of_axon=2500 //2500 axons, producing a connection probability of 2% (Scharfman, 2009) input_sample_size = 50 //how many axons each GC sample from number_of_input=25 //each axon produce 75 inputs that are distributed...
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NEURON
1,816
69
objref PC, PCvode PC= new ParallelContext() PC.nthread(256) dt=.1 //PC.runworker() RNGseed=31123 number_of_axon=2500 //2500 axons, producing a connection probability of 2% (Scharfman, 2009) input_sample_size = 50 //how many axons each GC sample from number_of_input=25 //each axon produce 75 inputs that are distributed...
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NEURON
1,816
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objref PC, PCvode PC= new ParallelContext() PC.nthread(256) dt=.1 //PC.runworker() RNGseed=31123 number_of_axon=2500 //2500 axons, producing a connection probability of 2% (Scharfman, 2009) input_sample_size = 50 //how many axons each GC sample from number_of_input=25 //each axon produce 75 inputs that are distributed...
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NEURON
1,816
69
objref PC, PCvode PC= new ParallelContext() PC.nthread(256) dt=.1 //PC.runworker() RNGseed=31123 number_of_axon=2500 //2500 axons, producing a connection probability of 2% (Scharfman, 2009) input_sample_size = 50 //how many axons each GC sample from number_of_input=25 //each axon produce 75 inputs that are distributed...