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--- title-block-banner: true title: "Analysis of Gfap and PDGFRβ reactivity in the ipsilateral hemisphere of KLF4-KO animals" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - na...
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480
--- title-block-banner: true title: "Point pattern analysis (PPA) for Ki67 expression in the ipsilateral hemisphere" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Unive...
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--- title-block-banner: true title: "Analysis of Ki67/PDGFRβ colocalization in defined ROIs of the ipsilateral hemisphere" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name:...
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--- title-block-banner: true title: "Analysis of PDGFR-β morphology in defined ROIs" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Univerisity Laval department...
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--- title-block-banner: true title: "Analysis of PDGFR-β mRNA (FISH) in KLF4-Flox and PDGFR-β-Cre mice (Control experiment)" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - nam...
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--- title-block-banner: true title: "Point pattern analysis (PPA) of PDGFR-β and GFAP+ cells (ipsilateral hemisphere)" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Uni...
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781
--- title-block-banner: true title: "Analysis of PDGFRβ mRNA (FISH) in the injured brain following cerebral ischemia" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Univ...
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--- title-block-banner: true title: "Analysis of KLF4 expression in the ipsilateral hemisphere of PDGFRβ^KLF4-KO mice" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Uni...
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--- title-block-banner: true title: "Analysis of KLF4/PDGFRβ colocalization in defined ROIs following ischemia" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Univerisit...
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--- title-block-banner: true title: "Analysis of hemispheric shrinkage following cerebral ischemia" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Univerisity Laval ...
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--- title-block-banner: true title: "Analysis of PDGFRβ reactivity (Integrated density) in the ipsilateral hemisphere" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Uni...
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--- title-block-banner: true title: "Analysis of CD31 and ColIV expression in the cortex of PDGFRβ^KLF4-KO mice" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Univerisi...
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--- title-block-banner: true title: "Analysis of GFAP reactivity (Integrated density) in the ipsilateral hemisphere" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Unive...
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--- title-block-banner: true title: "Analysis of Haralick features from PDGFRβ in defined ROIs" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Univerisity Laval ...
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--- title-block-banner: true title: "Structural analysis of KLF4-KO brains in the ipsilateral hemisphere" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Univerisity Lava...
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--- title: "Data handling for Widefield PDGFR-β and GFAP-stained barain sections (Ipsilateral hemisphere)" subtitle: "Data analysis notebook" author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Univerisity Laval department: Psychi...
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--- title-block-banner: true title: "Analysis of Klf4 expression in the ipsilateral hemisphere following cerebral ischemia" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name...
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--- title: "Supplementary tables" editor: visual format: html --- ::: {#tbl-panel_shrinkage layout-ncol="2"} | **Parameter** | **Est.** | **2.5 %** | **97.5 %** | |-----------------|----------|-----------|------------| | Intercept | 11.9 | 11.5 | 12.45 | | sigma_Intercept | 0.2 | -0.25 ...
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--- title-block-banner: true title: "Point pattern analysis (PPA) of PDGFR-β and GFAP+ cells (regions of interest)" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Univer...
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Quarto
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--- title-block-banner: true title: "Analysis of PDGFRβ attachment to vasculature (CD31+)" subtitle: "Data analysis notebook" date: today date-format: full author: - name: "Daniel Manrique-Castano" orcid: 0000-0002-1912-1764 degrees: - PhD affiliation: - name: Univerisity Laval depa...
015d4e176d8723845b6ae1b76e5b74579173c7b1f2cd0a65bb0a00330875455c
R
56
4
library(testthat) library(gGnome) test_check('gGnome')
54413c815fb77d3cc51323da0a66926feb0fc5223e765222147eb006822c7c25
R
60
4
library(testthat) library(transmit) test_check("transmit")
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R
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library(testthat) library(fragCounter) test_check("fragCounter")
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R
70
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library(testthat) library(JaBbA) test_check("JaBbA", filter="JaBbA")
336336f2ba610a2c4fd95681d74b0fff53886109822c41719aa981b6b8fe03a6
R
108
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### MixfMRI environment for storing global variables. .MixfMRIEnv <- new.env() .MixfMRIEnv$MPI.gbd <- FALSE
e8a58cc6c8807c2ca355220060de158cbfa9ba5e2148b3a2f3c6eb01ba383f5e
R
137
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library(pheatmap) data<-read.table("S-Fig3f_DAR_reverse_between_DG_CA_ATACseq_Zscore.txt") pheatmap(f,cluster_cols = F,show_rownames = F)
fdc1e399d47b8a259dfb4f25bc7fd875dc4c62eeceffe893644b786f4a72dba9
R
142
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z<-read.table("Fig3b_DAR_associated_gene_Exp.txt",header = T) ggplot(z, aes(x=Group, y=Exp, fill=Type)) + geom_boxplot()+ theme_classic()
310751dd8eed110459addd43a06e14262d97bee8a675b913a9afa6ac90b6f04d
R
167
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install.packages("lmerTest") install.packages("broom") install.packages("emmeans") install.packages("ggplot2") install.packages("gridExtra") install.packages("sjPlot")
d414225aaa9c3797f5f5913039ac515945e1a427aae3b42dea85de588ca439c5
R
180
3
library(pheatmap) data<-read.table("Fig1d.Region_sepcific_expressed_Gene_cpm_Zscore.txt",header = T) pheatmap(data,cluster_rows = F,cluster_cols = F,show_rownames = F,fontsize = 8)
b0717d8e1d28d93504a72283c17ccfb00ab278df6dee8501ab711ab4e37b9c83
R
210
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test_that("construct simple codebook", { codebook <- construct_codebook(c('A', 'B', 'C')) expect_equal(codebook$A$index,1) expect_equal(codebook$A$size,1) expect_equal(codebook$A$symbol,'A') })
b16e95bce16190863e0dbb489cb33593a7310f44443ce506d7e2b672b075190f
R
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10
#------------------------ # Plot phylogenetic tree # 25 Jan 2023 #------------------------ source("./common.R") # <<Figure 5>> plot.phylo(tree_en, tip.color = cl, font = 1) save_pdf("../data/derived/fig.5.pdf")
df2dc6e70924b05d5de40dde65c12d63e04c9310fb29bda7d485eb4e21ce57c0
R
248
6
summarized.overlap <- function(overlap.mat){ x <- eigen(overlap.mat, symmetric = T, only.values = T) p <- nrow(overlap.mat) if (p == 1) 1 else max(min((p * x$values[1] / sum(x$values) - 1) / (p - 1), 1), 0) } # End of summarized.overlap().
9d82b861f4a03af20a7c7706cdfce02723ac58b6999970a8762fbc396b120141
R
264
10
#!/usr/bin/env Rscript args=commandArgs(trailingOnly = T) numers=read.table(args[1], header=T, row.names=1, stringsAsFactors=F) #ss=strsplit(colnames(numers),split="_") #meta=do.call(rbind,ss) #colnames(meta)=c("sex","tissue","id") save(numers, file=args[2] )
4904387e0a6220ddfd5debae1f3503397d315dc111dd11c8d2a64fb567696a59
R
269
12
### Lastest load into a package. .onLoad <- function(libname, pkgname){ library.dynam("MixfMRI", pkgname, libname) invisible() } # End of .onLoad(). .onUnload <- function(libpath){ library.dynam.unload("MixfMRI", libpath) invisible() } # End of .onUnload().
68a2155f0ce69e2dbd79e1ac00b3839f340578e4cbdfedd41f92d742058285b4
R
311
7
# Generated by using Rcpp::compileAttributes() -> do not edit by hand # Generator token: 10BE3573-1514-4C36-9D1C-5A225CD40393 count_spikes <- function(group_index, num_groups, spike_time, timesteps) { .Call('_transmit_count_spikes', PACKAGE = 'transmit', group_index, num_groups, spike_time, timesteps) }
5e0cbcfc4d8ba11161193915295624316c0d5b61b13c1b093022152f330cc4c8
R
345
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library(ggplot2) library(pheatmap) library("ggplotify") library(cowplot) setwd('output path') data =read.table('Sample_AverageExpression.xls',sep = '\t') res <- cor(data) res = round(res, 2) p1 = pheatmap(res,cluster_cols = T,cluster_rows = T) plot_list =as.ggplot(p1) ggsave(plot = plot_list,filename = 'cor_Sample.pd...
37f77f18f377ad8638150d0a99e9a5e765696fbfcb26bf37e4ff71a263d3b1ab
R
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library(MixfMRI, quietly = TRUE) source("00-set_condition.r") ### Test 2d data. da <- eval(parse(text = paste(case, sep = ""))) id <- !is.na(da) PV.gbd <- da[id] ### plot hist fn.plot <- paste("./plot/", case, "_hist.pdf", sep = "") pdf(fn.plot, height = 4, width = 6) hist(PV.gbd, nclass = 100, xlab = "p-val...
632b43a287f208a730ab4359e16053db94750dc2156834ed1ce302e61c102fe8
R
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### Do not delete this file and file name!! ### This file should be loaded before all other *.r files. ### This is to avoid the false positive messages from R CMD check. ### "no visible binding for global variable" ### Suggested by Prof Brian Ripley ### ?globalVariables if(getRversion() >= "2.15.1"){ utils::globalVar...
5997d2aeb5c60060edcff5df92eb16eee4cc4eb48d42ed02826645ce540e6770
R
372
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case <- "ds.pval" .FC.CT$algorithm <- "apecma" .FC.CT$model.X <- "V" .FC.CT$ignore.X <- FALSE .FC.CT$CONTROL$debug <- 1 .FC.CT$CONTROL$RndEM.iter <- 50 .FC.CT$INIT$min.1st.prop <- 0.99 .FC.CT$INIT$max.PV <- 0.05 K.min <- 2 K.max <- 20 max.try.fclust <- 3 seed <- 1234 if(!file.exists("output")){ dir.create("output")...
e23b4ec536b5e14b2a16de6508d2d146493ce8513a8c8c9c9232692b0441954a
R
372
20
case <- "ds.pval" .FC.CT$algorithm <- "apecma" .FC.CT$model.X <- "I" .FC.CT$ignore.X <- FALSE .FC.CT$CONTROL$debug <- 1 .FC.CT$CONTROL$RndEM.iter <- 50 .FC.CT$INIT$min.1st.prop <- 0.99 .FC.CT$INIT$max.PV <- 0.05 K.min <- 2 K.max <- 20 max.try.fclust <- 3 seed <- 1234 if(!file.exists("output")){ dir.create("output")...
822f8cb44e87fd1094316db8a22e5408c1a35c33231be35d584570f5e05a5136
R
375
20
case <- "jssv44i11" .FC.CT$algorithm <- "apecma" .FC.CT$model.X <- "I" .FC.CT$ignore.X <- FALSE .FC.CT$CONTROL$debug <- 1 .FC.CT$CONTROL$RndEM.iter <- 50 .FC.CT$INIT$min.1st.prop <- 0.975 .FC.CT$INIT$max.PV <- 0.05 K.min <- 2 K.max <- 20 max.try.fclust <- 3 seed <- 1234 if(!file.exists("output")){ dir.create("outpu...
4078acdef267f21846fb9670917ca0cdd3ccab32b9ab6e4ffac0eeb528617ba4
R
387
20
case <- "pval.olddata.complex" # case <- "pval.olddata.mag" .FC.CT$algorithm <- "apecma" .FC.CT$model.X <- "V" .FC.CT$ignore.X <- FALSE .FC.CT$CONTROL$debug <- 1 .FC.CT$CONTROL$RndEM.iter <- 100 .FC.CT$INIT$min.1st.prop <- 0.8 K.min <- 2 K.max <- 15 max.try.fclust <- 3 seed <- 1234 if(!file.exists("output")){ dir.c...
9b0c3b41791253f0b3edc42a73f92f11d350076f93c79e455d33463d589819bc
R
387
20
case <- "pval.olddata.complex" # case <- "pval.olddata.mag" .FC.CT$algorithm <- "apecma" .FC.CT$model.X <- "I" .FC.CT$ignore.X <- FALSE .FC.CT$CONTROL$debug <- 1 .FC.CT$CONTROL$RndEM.iter <- 100 .FC.CT$INIT$min.1st.prop <- 0.8 K.min <- 2 K.max <- 15 max.try.fclust <- 3 seed <- 1234 if(!file.exists("output")){ dir.c...
860c7f527d819cbec6e77067b777fc37c86757c4c28150b99064cddaf9b2e16c
R
395
22
library(shiny) library(shinyBS) library(shinyWidgets) library(tidyverse) library(stringr) library(Matrix) library(Seurat) library(metacell) library(scater) library(Biostrings) library(igraph) library(plotly) library(data.tree) library(collapsibleTree) library(phylocanvas) library(msaR) library(ape) library(shinycssloa...
0f73db3c4f442bcdaa2ee85c5d3ba5a92512691be9b1697f424814fbd2898a80
R
407
15
library(MixfMRI, quietly = TRUE) source("00-set_condition.r") ### Test 2d data. da <- eval(parse(text = paste(case, sep = ""))) id <- !is.na(da) PV.gbd <- da[id] # PV.gbd[PV.gbd > 0.3] <- runif(sum(PV.gbd > 0.3), 0.3, 1) ### plot hist fn.plot <- paste("./plot/", case, "_hist.pdf", sep = "") pdf(fn.plot, height = 4, w...
c24ac2c2f262b7b2e459dc51219b96dd8f6e62df3f0d3725239566e2a06d3c38
R
409
19
countMiceAndLitters <- function(df, filterByVar, groupingVars){ count <- df %>% filter( !is.na({{ filterByVar }}) ) %>% group_by(!!! groupingVars)%>% select( mouseID, damID, !!! groupingVars ) %>% summarise( numCells = n(), numMice = length(unique(mouseID)),...
21ddce02cefeb84c772f41ce30001b19339a14b2f341b713d8f4618dfcf39fa2
R
410
21
case <- "ds.pval" .FC.CT$algorithm <- "apecma" # .FC.CT$model.X <- "V" .FC.CT$ignore.X <- TRUE .FC.CT$CONTROL$debug <- 1 .FC.CT$CONTROL$RndEM.iter <- 50 .FC.CT$INIT$min.1st.prop <- 0.99 .FC.CT$INIT$max.PV <- 0.05 .FC.CT$INIT$class.method <- "simple" K.min <- 2 K.max <- 10 max.try.fclust <- 1 seed <- 1234 if(!file.exi...
53cff1f2380e506cf82aa46011ee6549ca2c1b0b70f1b2129d7be601d66382a8
R
425
21
case <- "pval.olddata.complex" # case <- "pval.olddata.mag" .FC.CT$algorithm <- "apecma" # .FC.CT$model.X <- "I" .FC.CT$ignore.X <- TRUE .FC.CT$CONTROL$debug <- 1 .FC.CT$CONTROL$RndEM.iter <- 100 .FC.CT$INIT$min.1st.prop <- 0.8 .FC.CT$INIT$class.method <- "simple" K.min <- 2 K.max <- 10 max.try.fclust <- 3 seed <- 123...
a8053296e152a6918371a7833f4f8502c484cd35fcfa4d919ead20342639e648
R
427
9
data<-read.table("Region_ctrl_DAR_NAc_other_RUVr_k3.txt",header = T) plot((-1)*data$logFC,-log10(data$FDR),pch=20,col="grey",xlab="log2FC",ylab="-log10(FDR)",main="NAc") d1<-data[data$logFC<(-1) & data$FDR<0.01,] points((-1)*d1$logFC,-log10(d1$FDR),pch=20,col="red") d2<-data[data$logFC>1 & data$FDR<0.01,] points((-1)*d...
5ba24b083504179681fecdac2301da9af73d308df57d1b41f9378dd303c531c5
R
428
17
#' The 'leafcutter' package. #' #' @description A DESCRIPTION OF THE PACKAGE #' #' @docType package #' @name leafcutter-package #' @aliases leafcutter #' @useDynLib leafcutter, .registration = TRUE #' @import methods #' @import Rcpp #' @import rstantools #' @importFrom rstan optimizing #' #' @references #' Stan Dev...
c25a9c36f6343afa769257f51611582449b06b4e82da89705a30c3a41fdf1f27
R
436
19
install.packages('ggplot2') install.packages('SimInf') install.packages('VSF') install.packages('devtools') install.packages('e1071') install.packages('nleqslv') install.packages('C:/Users/eric_fortune/Downloads/VFS_1.0.2.tar.gz', repos = NULL,type = 'source') install.packages('deSolve') install.packages('RMAWGEN’') l...
f50504592f73e0ce87acfe6224e1009bbff44caa29e8b02c2b8a5c0d28a9380d
R
447
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#!/usr/bin/Rscript # Loading data from stding args = commandArgs(trailingOnly=TRUE) metal = fread(args[1]) N = as.numeric(args[2]) ## Library loading .libPaths("/mnt/rreal/RDS/acarrasco/R_libs/") library(data.table) library(stringr) library(tidyverse) # To perfrom the harmonization QC, we used the code from -> https...
b73095756a993c9d952c621a50425ba2b8f724fe354124cf6e9677accdd17c48
R
491
11
library(ggplot2) NAc<-read.table("DistanceTSS_Region_ctrl_NAc_other_DAR.txt"); DG<-read.table("DistanceTSS_Region_ctrl_DG_other_DAR.txt"); CA<-read.table("DistanceTSS_Region_ctrl_CA_other_DAR.txt"); SVZ<-read.table("DistanceTSS_Region_ctrl_SVZ_other_DAR.txt"); a<-boxplot(as.numeric(NAc$V2/1000),as.numeric(DG$V2/1000),...
631af022f8ecade27e1068df1e6ae53ef06dd3ae342629bfe5cbfb4dfd041d1e
R
500
11
require(data.table) f <- fread("grep -v ^# /broad/broadsv/NA12878/GCAT/gcat_illumina_150x/snowman/v115/v115.snowman.indel.vcf", sep='\t') hdr <- fread("grep ^# /broad/broadsv/NA12878/GCAT/gcat_illumina_150x/snowman/v115/v115.snowman.indel.vcf", sep="\t", header=FALSE) ## rescale the quality score f[, SL := gsub(".*?:...
66f5ce41dc0960d82629def004e1f5d1e0e1471778110522b14828c16ab3a613
R
509
20
library(MixfMRI, quietly = TRUE) set.seed(1234) da <- gendataset(phantom = shepp2fMRI, overlap = 0.01)$pval ### Check 2d data. id <- !is.na(da) PV.gbd <- da[id] # pdf(file = "maitra_2d_fclust.pdf", width = 6, height = 4) hist(PV.gbd, nclass = 100, main = "p-value") # dev.off() ### Test 2d data. id.loc <- which(id, ar...
897909db93142f38f2f7c111400bd39e300c8d1ed52060aeb091b6d4b44e834a
R
516
21
library(MixfMRI, quietly = TRUE) dim <- c(4, 5, 4, 10) set.seed(123) da.ts <- array(rnorm(prod(dim)), dim = dim) id.class <- cba.cor(da.ts) table(id.class) fun.tanh <- function(a, B){ d <- 1 / apply(B, 2, function(b){ dist(rbind(as.vector(a), b)) }) tanh(d) } id.class.tanh <- cba.cor(da.ts, fun.sim = fun.tanh) tab...
41d7430534b9b46fe24b95f6c68da892dc2f01bb856bceb4d2f2ed59af9626b0
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--- title: "Advanced usage" author: "Jonas Simon Fleck" date: "5/18/2022" output: html_document --- ```{r, echo = FALSE, message=FALSE} knitr::opts_chunk$set(message = FALSE, warning = FALSE) ``` - Interaction terms - motifs - aggregation - Filtering the graph ```{r, results='hide'} library(tidyverse) library(Pando)...
944f419b8e16f83158a819446a84ed51ebdfee30c458d51bb5f891655efaa476
R
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library(pheatmap) data<-read.table("Fig2d_DEG_of_DG_CA_reverse_w_Zscore_Expression.txt",header = T) pheatmap(data[,3:ncol(data)],cluster_rows = F,cluster_cols = F,fontsize = 7) paletteLength <- 50 myColor <- colorRampPalette(c("navy", "white", "firebrick3"))(paletteLength) myBreaks <- c(seq(-2, 0, length.out=ceiling(p...
8217be2463b6753f448a456710b29f7a2b87f24e2da710972d91a12cdfd72329
R
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case <- "simu.2d" .FC.CT$algorithm <- "apecma" .FC.CT$model.X <- "V" .FC.CT$ignore.X <- FALSE .FC.CT$CONTROL$debug <- 1 .FC.CT$CONTROL$RndEM.iter <- 50 .FC.CT$INIT$min.1st.prop <- 0.95 .FC.CT$INIT$class.method <- "prob.extend" K.min <- 2 K.max <- 8 max.try.fclust <- 3 seed <- 1234 smooth <- FALSE if(!file.exists("out...
4cfb7364b203d8d40593a77855750c111932bae61ab27190ecea14cd8fdad0f5
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library(MixfMRI, quietly = TRUE) set.seed(1234) ### Test maitra's simulation. da <- gendataset(phantom = shepp1fMRI, overlap = 0.01)$pval id <- !is.na(da) PV.gbd <- da[id] id.loc <- which(id, arr.ind = TRUE) X.gbd <- t(t(id.loc) / dim(da)) ### Run noX and 2 clusters. .FC.CT$ignore.X <- TRUE .FC.CT$INIT$class.method <...
b2000fc47e8272f65c16bfacf5de34d1de5f4392c8dbb09c80b2015c75d4f728
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test_that("testing adding channel noise", { codebook <- construct_codebook(c('A', 'B', 'C')) signal <- encode_signal( codebook=codebook, symbol = 'A', signal_power = 3, duration_in_seconds = 10 ) result <- add_channel_noise( codebook, signal...
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R
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# logging which server was used to run this script system("echo \"Running this on ### $(hostname) ### \\(* w *)/\"") # load library library(tidyverse) library(ArchR) library(Seurat) set.seed(666) addArchRThreads(threads = 8) addArchRGenome("hg38") proj <- loadArchRProject(path = "Dracheva_ALS_FTD_latest_atac_anno_a...
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R
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library(tidyverse) df <- read_tsv("count_cell_barcodes_pre_post_multiplets_removal.txt", col_names = c("sample", "original_count", "filtered_count")) %>% mutate(rate = 100*(1 - (filtered_count/original_count)), rate = round(rate, 2)) p <- df %>% ggplot(aes(sample, original_count)) p + geom_bar(fill = "#D...
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### This file contains major functions for solving MLE of SIGMA. mle.SIGMA.I <- function(PARAM, i.k){ N.gbd <- PARAM$N.gbd p.X <- PARAM$p.X B <- W.plus.y(.MixfMRIEnv$X.gbd, -PARAM$MU[, i.k], N.gbd, p.X) * sqrt(.MixfMRIEnv$Z.gbd[, i.k] / .MixfMRIEnv$Z.colSums[i.k]) tmp.SIGMA <- colSums.gbd(B^2) tmp.SI...
619741690c61332800d25bf3fe7d1e686957dfd494796f6288497779576c8230
R
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library(MixfMRI, quietly = TRUE) set.seed(1234) ### Test 2d data. da <- pval.2d.mag id <- !is.na(da) PV.gbd <- da[id] id.loc <- which(id, arr.ind = TRUE) X.gbd <- t(t(id.loc) / dim(da)) ret <- fclust(X.gbd, PV.gbd, K = 3) print(ret) ### p-values of rest clusters. ret.lrt <- lrt(PV.gbd, ret$class, K = 3) print(ret.lrt...
4d54d9d3b99e0ba5f0773bdc699e707388200c307a3306fff19496ac8fc0ac24
R
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library(ggplot2) #St18 data<-read.table("Fig4f_gene_St18_expression_updata.txt",header = T) ggplot(data, aes(x=Region, y=St18, color=Drug)) + geom_boxplot(position=position_dodge(0.5),width=0.4)+ scale_x_discrete(limits=c("NAc","DG","CA","SVZ"))+ labs(title="St18",x="")+ theme_classic()+ theme(plot.title = ...
386b9bf29eb211a5f49cd3e48a3ea6f4529104ce7cb3a024bd27c4b9a71df4cc
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create_count_matrix <- function(data_input, data_type_input, rep_num_input) { if (data_type_input == "dna") { grep_pattern <- "^dna\\d" } else if (data_type_input == "rna") { grep_pattern <- "^rna\\d" } header_indeces <- colnames(data_input) %>% grep(pattern = grep_pattern) count_matrix <- cbind( ...
cbe0dde07cbb8d88d3acc0ed39941cd060626e0ae3026d90fd4df06a87f03320
R
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library(MixfMRI, quietly = TRUE) library(EMCluster, quietly = TRUE) # .FC.CT$algorithm <- "apecma" # .FC.CT$model.X <- "V" # .FC.CT$ignore.X <- TRUE set.seed(1234) ### Test toy1. X.gbd <- toy1$X.gbd X.range <- apply(X.gbd, 2, range) X.gbd <- t((t(X.gbd) - X.range[1,]) / (X.range[2,] - X.range[1,])) PV.gbd <- toy1$PV.g...
0091fad3987710f243606724ceac41623f4caa8a27a3a30cdd477d2558f1969b
R
735
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library(MixfMRI, quietly = TRUE) library(EMCluster, quietly = TRUE) # .FC.CT$algorithm <- "em" # .FC.CT$model.X <- "V" # .FC.CT$ignore.X <- TRUE set.seed(1234) ### Test toy1. X.gbd <- toy1$X.gbd[, -3] X.range <- apply(X.gbd, 2, range) X.gbd <- t((t(X.gbd) - X.range[1,]) / (X.range[2,] - X.range[1,])) PV.gbd <- toy1$PV...
9bac6f973aff694a8b478bfc880fd5bab160e59fb82470ad31767bbbc097041f
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### compute correlation cba.cor <- function(da.ts, da.m = NULL, adj.dist = TRUE, fun.sim = stats::cor){ dim.da.ts <- dim(da.ts) if(!is.null(da.m)){ dim.da.m <- dim(da.m) if(length(dim.da.ts) != (length(dim.da.m) + 1)){ stop("Dimension lengths of da.ts and da.m do not match.") } if(any(d...
647ba8a11b8c3e74382f65959cdbe42e1378d3857b5902e65118da529a551520
R
758
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library(MixfMRI, quietly = TRUE) library(EMCluster, quietly = TRUE) # .FC.CT$algorithm <- "apecma" # .FC.CT$model.X <- "V" # .FC.CT$ignore.X <- TRUE set.seed(1234) ### Test pstats id <- which(!is.na(pstats)) PV.gbd <- pstats[id] X.gbd <- which(!is.na(pstats), arr.ind = TRUE) X.range <- apply(X.gbd, 2, range) X.gbd <-...
c2de589be3c3eba85e14d6c2e2947779343424b7656441c379d12d9421c52ea4
R
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library(ggplot2) data<-read.csv("Fig5a_Motif_enriched_in_DAR.txt",header = T,sep="\t") ggplot(data,aes(x=Type, y=GENE, size = -log10(LogPvalue), col =Percent ))+ geom_point(alpha=1) + scale_size(range = c(0.01, 3))+ scale_color_gradient2( low="grey", mid="orange", high="red" ) + theme(axis.text.x = element_te...
ff339c16d329136fea0ce64057020d22ed9564a8875427180af9f7b517f3e96d
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library(ggplot2) require("ggrepel") data<-read.table("Fig4e_DAR_enhancer_Gene_Exp.txt",header = T) f<-data f$Significant <- ifelse(f$Exp_FDR < 0.05 & (f$DAR_logFC*f$Exp_logFC > 0), "FDR < 0.05", "Not Sig") ggplot(f, aes(x = (-1)*DAR_logFC, y = (-1)*Exp_logFC, shape = Region,size=-log10(Exp_FDR)))+ geom_hline(yinterc...
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library(MixfMRI, quietly = TRUE) set.seed(1234) da <- gendataset(phantom = shepp1fMRI, overlap = 0.01)$pval set.seed(1234) da2 <- gendataset(phantom = shepp2fMRI, overlap = 0.01)$pval xlim <- ylim <- c(0.19, 0.82) # pdf(file = "maitra_2d.pdf", width = 4, height = 4) # par(mfrow = c(2, 2), mar = c(0, 0, 1, 0)) par(mfro...
22466140aa5c87d11083b8b59de571f0288d9e8c282b47e655dec350c00be449
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# logging which server was used to run this script system("echo \"Running this on ### $(hostname) ### \\(* w *)/\"") # load library library(tidyverse) library(Seurat) library(sctransform) library(scales) # read in full dataset with 1st round annotation data_obj_sub <- readRDS("./seurat_objects/snRNA_cellBneder_correc...
c742c05ec680b1d60fa60e1c1dd522662f554009fbaf326b05d0e23487669dfb
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### Get the Cov(logit eta_k) and 95% CE. ### Partial logL. Return a matrix with dimension M * N. # partial.logL.I <- function(x, ETA, BETA, MU, SIGMA, post.z) ### Paritial all logit(eta_k). Return a K * (K - 1) partial.logit.p <- function(ETA){ K <- length(ETA) d.dETA <- 1 / ETA + 1 / (1 - ETA) ret <- diag(d.dE...
d4944a3a74b41f89d57c97bc7ae76e61bd8b291d146465d407fdfee8f5e562e7
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# time series step = 7 #in weeks year = 365 num_year = 15 n = 52 * num_year t = seq(0, year*num_year , by = step) a <- 25 b <- 1/58 c <- 10 d <- 1/24 c.unif <- runif(n) c.norm <- rnorm(n) amp <- 5 amp2 <- 5 offset <- 13 #temp data set.seed(1) y1 <- a*sin(b*t-4)+c.norm*amp #precipitation set....
c99e5f99edc2e407f0441900fd362bd07a991fd434ed1f6582c86e6c3e85cb39
R
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library(MixfMRI, quietly = TRUE) .FC.CT$model.X <- "I" .FC.CT$CONTROL$debug <- 0 K <- 3 ### Fit toy1. set.seed(1234) X.gbd <- toy1$X.gbd X.range <- apply(X.gbd, 2, range) X.gbd <- t((t(X.gbd) - X.range[1,]) / (X.range[2,] - X.range[1,])) PV.gbd <- toy1$PV.gbd fcobj <- fclust(X.gbd, PV.gbd, K = K, min.1st.prop = 0.5) ...
306588a86f29fd82881060ff2ce04e96592325c10f82b75453617553d870d74e
R
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library(MixfMRI, quietly = TRUE) library(EMCluster, quietly = TRUE) .FC.CT$model.X <- "I" .FC.CT$CONTROL$debug <- 0 .FC.CT$check.X.unit <- FALSE ### Fit toy1. set.seed(1234) X.gbd <- toy1$X.gbd PV.gbd <- toy1$PV.gbd ret.2 <- fclust(X.gbd, PV.gbd, K = 2) ret.3 <- fclust(X.gbd, PV.gbd, K = 3) ret.4 <- fclust(X.gbd, PV.g...
c1af1be8dba9a5a7272eb9f5c228fc2b755fd6299b38173ed2732c3e70320286
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library(ggplot2) data<-read.table("S-Fig5c_DEG_TF_logFC_FDR.txt") mid<-0 ggplot(data,aes(x=Region, y=Gene, size = -log10(FDR), col =LogFC ))+ geom_point(alpha=1) + scale_color_gradient2(midpoint=mid, low="navy", mid="white", high="firebrick3" ) + scale_size(range = c(0.01, 3))+ scale_x_discrete(limits=c("NAc"...
5985fba19bb6411c21d90d627d77dc03955593288dcc9e7e6b0cefa0a73afe22
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### For work flows only. get.workflow <- function(dir.name = "workflow/", parallel = c("spmd"), pkg = "MixfMRI"){ dir.name <- paste(dir.name, parallel[1], "/", sep = "") file.path <- tools::file_path_as_absolute( system.file(dir.name, package = "MixfMRI")) file.path } # End of get.workflow()...
3b62fc0ab81b1601a5add1e31b178a094e1797a8a1dd21549bb623687fbf3d3e
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### Density of mulitvariate normal distribution. # X: N.gbd by p.X # MU: length p.X # full: p.X by p.X dmvn <- function(X, MU, full, log = FALSE){ N <- nrow(X) p <- ncol(X) tmp.S <- full logdet <- log(abs(det(tmp.S))) B <- W.plus.y(X, -MU, N, p) tmp.S <- solve(tmp.S) distval <- rowSums((B %*% tmp.S) * ...
d82fc57418a747537880563fd1a87e3f9ce7d9d2242fb8217cffe5c3431a7ca9
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838
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# logging which server was used to run this script system("echo \"Running this on ### $(hostname) ### \\(* w *)/\"") # load library library(tidyverse) library(ArchR) library(Seurat) set.seed(666) addArchRThreads(threads = 16) addArchRGenome("hg38") proj <- loadArchRProject(path = "Dracheva_ALS_FTD_latest_atac_anno_...
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R
841
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printTtestText <- function(t_test){ pval <- t_test$p.value pText <- case_when( pval < 0.001 ~ "<0.001", pval > 0.999 ~ ">0.999", TRUE ~ as.character(paste0("==", round(pval, 3))) ) text <- paste0( ## Uses plotmath to format "list(", "italic(t)", # italic t "[", round(t_test$parameter, 2...
bfc26a544190859f3bed5baa4205fcac771f1c74ae35feacee811fe3a53ced1e
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library(MixfMRI, quietly = TRUE) set.seed(1234) ### Check 2d data. da <- pval.2d.complex id <- !is.na(da) PV.gbd <- da[id] hist(PV.gbd, nclass = 100, main = "p-value") ### Test 2d data. id.loc <- which(id, arr.ind = TRUE) X.gbd <- t(t(id.loc) / dim(da)) ret <- fclust(X.gbd, PV.gbd, K = 3) print(ret) ### p-values of ...
d0033056d6a4b12f77ff38814d3aefe101745b4aebbb106e9bb0246f14e42281
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toCPXMatrix <- function(Amat){ if (is.null(Amat)) { return(NULL) } else if (is(Amat, "sparseMatrix")) { Amat <- as(Amat, "dgCMatrix") matbeg <- Amat@p matcnt <- diff(c(Amat@p, length(Amat@x))) matind <- Amat@i matval <- Amat@x } else if (is(Amat, "simple_trip...
9965273bdb7afe82f20185d5987024e28365c307a28dc8f1bd8d2d77d2ee49c3
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test_that("example transmission", { codebook <- construct_codebook(c('A', 'B', 'C')) decoded_signal <- transmit_signal( codebook=codebook, symbol = 'A', signal_power = 10, noise_power = 10, duration_in_seconds = 10, time_interval = 0.1, entropy_threshold =...
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874
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ret.summary <- list() ret.jaccard.summary <- list() ret.alternative <- list() ret.jaccard.alternative <- list() for(i.rep in 1:25){ prefix <- paste("simu_2d_", sprintf("%02d", i.rep), "/new/", sep = "") fn <- paste(prefix, "summary_table/summary_table.rda", sep = "") load(fn) ret.summary[[i.r...
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R
879
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# Compute AIC and BIC for given PARAM. aic <- function(PARAM){ d <- compute.d(PARAM) -2 * PARAM$logL + 2 * d } # End of aic(). bic <- function(PARAM){ d <- compute.d(PARAM) -2 * PARAM$logL + d * log(PARAM$N) } # End of bic(). icl.bic <- function(PARAM){ d <- compute.d(PARAM) -2 * PARAM$logL + d * log(PAR...
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R
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ret.summary <- list() ret.jaccard.summary <- list() ret.alternative <- list() ret.jaccard.alternative <- list() for(i.rep in 1:25){ prefix <- paste("simu_2d_", sprintf("%02d", i.rep), "/new/", sep = "") fn <- paste(prefix, "summary_table/summary_table_new4.rda", sep = "") load(fn) ret.summary...
cb58a2a10a687525794e4a57ae36bcb578fbf08a6405a15810196f6cdb94f3a1
R
884
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ret.summary <- list() ret.jaccard.summary <- list() ret.alternative <- list() ret.jaccard.alternative <- list() for(i.rep in 1:25){ prefix <- paste("simu_2d_", sprintf("%02d", i.rep), "/new/", sep = "") fn <- paste(prefix, "summary_table/summary_table_new5.rda", sep = "") load(fn) ret.summary...
256028e6907cf09e2dfd4779361c4f0a7ffc316229a5ab067e189292beebfaa2
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887
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# logging which server was used to run this script system("echo \"Running this on ### $(hostname) ### \\(* w *)/\"") # load library library(tidyverse) library(ArchR) library(Seurat) set.seed(666) addArchRThreads(threads = 8) addArchRGenome("hg38") proj <- loadArchRProject(path = "Dracheva_ALS_FTD_latest_atac_anno_a...
ec8890865f4131878dd62cb6db6b2d48049f390bd694d7ce5cbbc4c17f0ba895
R
894
32
library(MixfMRI, quietly = TRUE) library(EMCluster, quietly = TRUE) # .FC.CT$algorithm <- "em" # .FC.CT$model.X <- "V" # .FC.CT$ignore.X <- TRUE ### Test toy1. set.seed(1234) X.gbd <- toy1$X.gbd X.range <- apply(X.gbd, 2, range) X.gbd <- t((t(X.gbd) - X.range[1,]) / (X.range[2,] - X.range[1,])) PV.gbd <- toy1$PV.gbd P...
0242b33352310219c40486b06eec13cccf35705adee6cbc4a00c9566265406cf
R
896
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toCPXMatrix <- function(Amat){ ## if (is.null(Amat)) { ## return(NULL) ## } else if (is(Amat, "sparseMatrix")) { Amat <- as(Amat, "dgCMatrix") matbeg <- Amat@p matcnt <- diff(c(Amat@p, length(Amat@x))) matind <- Amat@i matval <- Amat@x ## } else if (is(Amat, ...
345d7475595fea6558c9765bd920e01b6ddee8a4aa8d11ba2eb244f9aa4541cc
R
904
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files<-list.files(pattern = "txt") #NAc f<-read.table(files[5]); d<-read.table(files[6]) plot((-1)*f$logFC,(-1)*d$logFC,xlab = "DEG:logFC", ylab="DEG's promoter: logFC", pch=20,main = "NAc") abline(h=0,lty=2,col="red"); abline(v=0,lty=2,col="red") #DG f<-read.table(files[3]); d<-read.table(files[4]) plot((-1)*f$lo...
31f59157c608bf8cd07f7329957ce2e9469ad5b0267634c823ecf42ada20ef23
R
907
34
library(ArchR) library(stringr) marker = read.table('marker.txt',sep = '\t',header =T) ### marker list proj = loadArchRProject('adult_Save-ProjAxolotl2') ## data cor = read.csv('color.txt',sep = '\t',header =F) ## color list library(dplyr) anno = read.csv('annonation.csv',header =T) ## annotation list anno = anno[,...
2db5e76742104af8d89ad37d356cf3aee661b7c575c59aa28ed3c8e0e58a2b16
R
917
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### SHELL> mpiexec -np 4 Rscript mpi_fclust2d.r library(MixfMRI, quietly = TRUE) library(EMCluster, quietly = TRUE) library(pbdMPI, quietly = TRUE) init() .FC.CT$MPI.gbd <- TRUE # .FC.CT$algorithm <- "em" # .FC.CT$model.X <- "V" # .FC.CT$ignore.X <- TRUE set.seed(1234) ### Test toy1. X.gbd <- toy1$X.gbd[, -3] X.range...
26d13b4d9b60aba127537e1a45ac5eb8b73141c8922ccc3731f0894ea70c2165
R
922
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# 00-paths.R # # Resolves dataFolder and outputFolder from environment variables, with # platform-aware WSL/Windows switching and an in-repo fallback. # Sourced by 01-set-up.R; also sourceable standalone by pipeline scripts # that do not need the full setup (packages, functions, etc.). # # Sets: dataFolder, outputFolde...
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924
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# logging which server was used to run this script system("echo \"Running this on ### $(hostname) ### \\(* w *)/\"") # load library library(tidyverse) library(Seurat) library(sctransform) ## read the post-QC seurat object data_obj_sub <- readRDS("./seurat_objects/snRNA_cellBender_corrected_postQC_SeuratV4_object.rds"...
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931
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# logging which server was used to run this script system("echo \"Running this on ### $(hostname) ### \\(* w *)/\"") # load library library(tidyverse) library(Seurat) filtered_cells_obj <- readRDS("./seurat_objects/snRNA_cellBender_corrected_QC_filteredCells_scTransformed_SeuratV4_object.rds") aibs_obj <- readRDS("/c...