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BioASQBlurb_5_WITH_RELATION_vqc_hetionet_normalized

original_question stringlengths 21 168	id stringlengths 11 13	sentence1 stringlengths 26 211	sentence2 stringlengths 108 23.5k	label stringclasses 2 values
Is the protein Papilin secreted?	converted_0	Is the protein Papilin secreted?	Using expression analysis, we identify three Genes that are transcriptionally regulated by HLH-2: the PROTOCADHERIN 3 cdh-3, and two Genes encoding secreted Extracellular Matrix Proteins, ERBB Receptor Feedback Inhibitor 1/papilin and him-4/hemicentin. We found that ERBB Receptor Feedback Inhibitor 1 encodes long (MIG...	yes
Are long non coding RNAs spliced?	converted_1	Are long non coding RNAs spliced?	Our analyses indicate that lncRNAs are generated through pathways similar to that of protein-coding genes, with similar histone-modification profiles, splicing signals, and exon/intron lengths. For alternative exons and long noncoding RNAs, splicing tends to occur later, and the latter might remain unspliced in some ca...	yes
Is RANKL secreted from the cells?	converted_2	Is TNFSF11 protein, human wt Allele secreted from the Cells?	Osteoprotegerin (Panoramic Radiography) is a soluble secreted factor that acts as a TNFRSF10C gene for receptor activator of NF-κB ligand (TNFSF11 protein, human protein, human wt Allele) Osteoprotegerin (Panoramic Radiography) is a secreted glycoprotein and a member of the Tumor Necrosis Factor Receptor superfamily. ...	yes
Does metformin interfere thyroxine absorption?	converted_3	Does metformin interfere thyroxine absorption?	LT4 absorption is unchanged by concomitant metformin ingestion. It has been hypothesized that metformin may suppress serum thyrotropin (TSH) concentrations by enhancing LT4 absorption or by directly affecting the hypothalamic-pituitary axis.[SEP]	no
Has Denosumab (Prolia) been approved by FDA?	converted_4	Has Denosumab (Prolia) been approved by FDA?	Denosumab is a RANK-ligand antibody that was approved by the FDA in 2010 for the prevention of skeletal fractures in patients with bone metastases from Solid Neoplasm. The authors present the imaging findings and technical report of an attempted percutaneous vertebroplasty in the only patient found to be actively unde...	yes
Are transcription and splicing connected?	converted_5	Are transcription and splicing connected?	, as splicing is often cotranscriptional, a complex picture emerges in which splicing regulation not only depends on the balance of RNA Splicing Factors binding to their mRNA Precursor target sites but also on transcription-associated features such as Protein Info recruitment to the transcribing machinery and elongatio...	yes
Is Alu hypomethylation associated with breast cancer?	converted_6	Is Alu hypomethylation associated with Malignant neoplasm of Breast?	Alu and Long Interspersed Nucleotide Element-1 hypomethylation is associated with ERBB2 wt Allele enriched subtype of Malignant neoplasm of Breast In IBC, Alu hypomethylation correlated with negative Estrogen Receptors (Endoplasmic Reticulum) status In survival analyses, low Alu methylation status tended to be associat...	yes
Proteomic analyses need prior knowledge of the organism complete genome. Is the complete genome of the bacteria of the genus Arthrobacter available?	converted_7	Proteomic analyses need prior knowledge of the organism complete genome. Is the complete genome of the bacteria of the genus Arthrobacter available?	Complete genome sequence of Arthrobacter phenanthrenivorans type strain (Sphe3). Complete genome sequence and metabolic potential of the quinaldine-degrading bacterium Arthrobacter sp. Rue61a. Here, we described the high quality draft genome sequence, annotations and the features ofArthrobactersp. B6. Complete genome s...	yes
Do mutations of AKT1 occur in meningiomas?	converted_8	Do Gene Mutation of AKT1 protein, human occur in Meningioma?	The recent identification of somatic Gene Mutation in components of the SHH-GLI1 and AKT1 protein, human protein, human-MTOR signaling pathways indicates the potential for cross talk of these pathways in the development of Meningioma. A Mutation Abnormality in PIK3CA gene gene or AKT1 protein, human protein, human was ...	yes
Does physical activity influence gut hormones?	converted_9	Does physical activity influence gut hormones?	Increases in blood Peptide YY, human(3-36) levels were dependent on the exercise intensity (effect of session: P<0.001 by two-way ANOVA), whereas those in Glucagon-Like Peptide 1 levels were similar between two different exercise sessions. A decrease in serum leptin levels (-48.4%, p < 0.001) was observed after interve...	yes
Is irritable bowel syndrome more common in women with endometriosis?	converted_10	Is Irritable Bowel Syndrome more common in women with Endometriosis?	CONCLUSIONS: Comorbid pain syndromes, mood conditions and Asthma are common in adolescents and young women with Endometriosis. There are many etiologies of Pelvic pain female that present with symptoms resembling those of Endometriosis-associated Pelvic pain female that are not diagnosable with laparoscopy, such as Chr...	yes
Does BNP increase after intensive exercise in athletes?	converted_11	Does nesiritide increase after intensive exercise in athletes?	NT-pro-nesiritide was significantly elevated postexercise in both adults and adolescents and remained above baseline at 24 h in both groups. NT-pro-nesiritide concentrations increased significantly (28 +/- 17.1 vs 795 +/- 823 ng x L, P < 0.05), whereas postrace Troponin T, Cardiac Muscle were elevated in just five athl...	yes
Are there web based self management strategies for chronic pain ?	converted_12	Are there web based self management strategies for Chronic Pain:-:Point in time:^Patient:- ?	Fibromyalgia Symptom Reduction by Online Behavioral Self-monitoring, This study aimed to evaluate effects of a web-based, self-monitoring and symptom management system (SMARTLog) that analyzes personal self-monitoring data and delivers data-based feedback over time. Moderate use (3 times weekly x 3 months) increased l...	yes
Is Weaver syndrome similar to Sotos?	converted_13	Is Weaver syndrome similar to Sotos?	Overgrowth conditions are a heterogeneous group of disorders characterised by increased growth and variable features, including Macrocephaly, distinctive facial appearance and various degrees of Learning difficulties and Intellectual Disability. Among them, Sotos and Weaver syndromes are clinically well defined and due...	yes
Is peripheral neuroepithelioma related to Ewing sarcoma?	converted_14	Is Peripheral Neuroectodermal Tumor, Primitive related to Ewing sarcoma?	The term "small round-cell tumor" describes a group of highly aggressive malignant tumors composed of relatively small and monotonous undifferentiated cells with high Nuclear (incident type) to cytoplasmic ratios. This group includes Ewing's sarcoma of bone of Specimen Type - Bone (ES), Peripheral Neuroectodermal Tumor...	yes
Is c-met involved in the activation of the Akt pathway?	converted_15	Is c-met involved in the activation of the Proto-Oncogene Proteins c-akt pathway?	Amplification of methionine has been reported in approximately 5%-22% of Lung Neoplasms with acquired resistance to small-molecule inhibitors of the epidermal growth factor receptor (Epidermal Growth Factor Receptor). Resistance to Epidermal Growth Factor Receptor inhibitors is likely mediated through downstream activa...	yes
Is pregnancy an additional risk during during H1N1 infection?	converted_16	Is pregnancy an additional risk during during H1N1 Communicable Diseases?	H1N1 influenza in pregnancy can be associated with severe complications This case series confirms a high number of complications in pregnant women due to pandemic H1N1/09. Pregnant women might be at increased risk for complications from pandemic H1N1 Virus Communicable Diseases. Pregnant women are at increased risk for...	yes
Are long non coding RNAs as conserved in sequence as protein coding genes?	converted_17	Are long non coding RNAs as conserved in sequence as protein coding genes?	Most lncRNAs are under lower sequence constraints than protein-coding genes and lack conserved secondary structures, making it hard to predict them computationally. hey are under stronger selective pressure than neutrally evolving sequences-particularly in their Promoter Regions, Genetic, which display levels of select...	no
Is TENS machine effective in pain?	converted_18	Is Transcutaneous Electric Nerve Stimulation machine effective in pain?	Transcutaneous electrical nerve stimulation is widely used in pain management but its effectiveness depends on the stimulation being targeted appropriately hypoalgesic effects of transcutaneous electrical nerve stimulation upon experimentally induced ischaemic pain. The results of this study have provided evidence of t...	yes
Is there any algorithm for enhancer identification from chromatin state?	converted_19	Is there any algorithm for Enhancer of transcription identification from chromatin state?	RFECS: a random-forest based algorithm for Enhancer of transcription identification from chromatin state. However, only a limited number of cell types or chromatin marks have previously been investigated for this purpose, leaving the question unanswered whether there exists an optimal set of Histone antigen modificatio...	yes
Are transcribed ultraconserved regions involved in cancer?	converted_20	Are transcribed ultraconserved regions involved in cancer?	Although most cancer research has focused in RNA, Messenger, non-coding RNAs are also an essential player in tumorigenesis. In addition to the well-recognized microRNAs, recent studies have also shown that epigenetic silencing by CpG Islands hypermethylation of other classes of non-coding RNAs, such as transcribed ultr...	yes
Do patients with Pendred syndrome present congenital deafness?	converted_21	Do patients with Pendred's syndrome present Congenital Hearing Loss, Partial?	Pendred Syndrome can be characterized by the triad composed of familial goitre, abnormal perchlorate discharge and Congenital Hearing Loss, Partial. Pendred's syndrome is an Autosomal Recessive Disorder characterized by Congenital Hearing Loss, Partial and goiter. Pendred's syndrome comprises congenital sensorineural ...	yes
Is CD56 useful in Ewing sarcoma prognosis?	converted_22	Is NCAM1 wt Allele useful in Ewings sarcoma prognosis?	Excellent prognosis in a subset of patients with Ewings sarcoma identified at diagnosis by NCAM1 wt Allele using flow cytometry There was a highly significant correlation between NCAM1 wt Allele expression and progression-free survival (PFS; 69% in low/negative expression versus 30% in high expression groups, P = 0.024...	yes
Are there any urine biomarkers for chronic kidney disease?	converted_23	Are there any urine biomarkers for chronic Both kidneys disease?	Kidney and urine proteomic biomarkers are considered as promising diagnostic tools to predict CKD progression early in Diabetic Nephropathy, facilitating timely and selective intervention that may reduce the related health-care expenditures. Both blood and urine biomarkers are reviewed in this paper and offer a conside...	yes
Is valproic acid effective for glioblastoma treatment?	converted_24	Is valproic acid effective for glioblastoma treatment?	A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma Multiforme Multiforme. PURPOSE: valproic acid (VPA) is an antiepileptic agent with Histone Deacetylase Inhibitor [EPC] therapy (HDACi) activity shown to sensitize glioblastom...	yes
Can Levoxyl (levothyroxine sodium) cause insomnia?	converted_25	Can Levoxyl (levothyroxine sodium) cause insomnia?	METHODS: Seventy-one patients diagnosed with Acquired hypothyroidism were randomly allocated into two study groups: the first group received usual dose of levothyroxine and the second group received combination of levothyroxine and liothyronine for at least 4 months. The main outcomes were psychosocial problems (Goldbe...	yes
Is fatigue prevalent in patients receiving treatment for glioblastoma?	converted_26	Is fatigue prevalent in patients receiving treatment for glioblastoma?	By contrast, fatigue worsened over time, with a difference in mean score of 5.6 points between baseline and 4-month follow-up (P=.02). In the GB cohort, the most common side effects were fatigue (56 %), Diarrhea (44 %), Neutrophil count decreased (31 %), and THROMBOCYTOPENIA 2 (disorder) (25 %). A total of 37 patients...	yes
Does the CTCF protein co-localize with cohesin?	converted_27	Does the CTGF protein, Homo sapiens protein co-localize with cohesins?	To investigate cohesins-non-CTGF protein, Homo sapiens (CNC) binding events in vivo we mapped cohesins and CTGF protein, Homo sapiens, as well as a collection of tissue-specific and ubiquitous transcriptional regulators using Chromatin Immunoprecipitation Sequencing in primary Mus sp. liver. In contrast to regions of t...	yes
Are stress granules involved in the pathogenesis of Amyotrophic Lateral Sclerosis?	converted_28	Are Stress Granules involved in the pathogenesis of Amyotrophic Lateral Sclerosis?	Shprintzen-Goldberg syndrome have been linked to several pathologies including inflammatory diseases, Primary malignant neoplasm, Virus Diseases, and Neurodegenerative Disorders such as AMYOTROPHIC LATERAL SCLEROSIS 1 (ALS) and frontotemporal dementia (Frontotemporal dementia). Like several other ALS-associated Protein...	yes
Does TGF-beta play a role in cardiac regeneration after myocardial infarction?	converted_29	Does Recombinant Transforming Growth Factor-Beta play a role in cardiac regeneration after myocardial infarction?	We then performed a chemical screen and identified several small molecules that increase or reduce Myocytes, Cardiac proliferation during heart development. These compounds act via Subfamily Erinaceinae, Insulin-Like Growth Factor I or Transforming growth factor β signaling pathways. Here, we report that the balance b...	yes
Is DITPA a thyroid hormone analog utilized in experimental and clinical studies	converted_30	Is DITPA a thyroid hormone analog utilized in experimental and clinical studies	DITPA normalized the elevated serum T(3) and Thyrotropin:-:Pt:Ser/Plas:- when the dose reached 1 mg/kg · d and T(4) and rT(3) increased to the lower normal range. The identification of 3,5-diiodothyropropionic acid (DITPA) that binds to both α- and β-type threonine-tRNA ligase activity with relatively low affinity was ...	yes
Is MammaPrint cleared by the United States Food and Drug Administration?	converted_31	Is MammaPrint cleared by the United States Food and Drug Administration?	Real-time RT-PCR confirmed the 5-gene prognostic signature that was distinct from an FDA-cleared 70-gene signature of MammaPrint panel and from the Oncotype DX Breast Cancer Assay Breast Cancer Assay recurrence score assay panel.[SEP]	yes
Is amantadine effective for treatment of disorders conciousness?	converted_32	Is amantadine effective for treatment of disorders conciousness?	We here provide a systematic overview of the therapeutic effects of amantadine, apomorphine and zolpidem in patients recovering from Apraxia, oculomotor, Cogan type. Evidence from clinical trials using these commonly prescribed pharmacological agents suggests positive changes in the neurological status in patients, lea...	yes
Is GAGA associated with nucleosome-free regions (NFR)?	converted_33	Is Gaga associated with nucleosome location-free regions (NFR)?	One of the three nuclease hypersensitive sites in the Fab-7 boundary, EEF1A2 wt Allele, contains multiple consensus-binding sequences for the Gaga factor, a Protein Info known to be involved in the formation and/or maintenance of nucleosome location location-free regions of chromatin location location. The SPHEROCYTOSI...	yes
Is amiodarone a class I anti-arrhythmic drug?	converted_34	Is amiodarone a Canadian Cardiovascular Society Grading Scale Class I Antiarrhythmic [EPC] drug?	Common Canadian Cardiovascular Society Grading Scale Class I agents are excluded due to the inherent abnormal cardiac structure and function in the setting of Shock, Cardiogenic. Class III drug options include dofetilide and amiodarone. amiodarone has been used as an Antiarrhythmic [EPC] drug since the 1970s and has an...	no
Has the protein TIEG1 been associated with apoptosis?	converted_35	Has the protein TIEG1 been associated with apoptosis?	Recombinant Transforming Growth Factor-Beta) inducible early gene 1 (TIEG1) is known to induce apoptosis in Recombinant Transforming Growth Factor-Beta sensitive Malignant neoplasm of pancreas Cells, yet its effect on Recombinant Transforming Growth Factor-Beta resistant cancer Cells remains unclear overexpression of T...	yes
Is PTEN involved in follicular thyroid carcinoma?	converted_36	Is PTEN protein, human involved in Follicular THYROID DIAGNOSTIC RADIOPHARMACEUTICALS carcinoma?	Two of the 259 patients (0.8%), with both Follicular THYROID DIAGNOSTIC RADIOPHARMACEUTICALS carcinoma and Large head (disorder), were found to carry a germline mutation in the PTEN protein, human protein, human gene. The PTEN protein, human protein, human mutation frequency in unselected cases of Follicular THYROID DI...	yes
Does strenuous physical activity affect thyroid hormone metabolism?	converted_37	Does strenuous physical activity affect Thyroid Hormones metabolism?	The results of the present study in a unique experimental human model of maximal exposure to altitude and physical exercise demonstrate that extreme HA and strenuous physical exercise are coupled with specific endocrine adaptations. These include increased activity of the GH/IGF-I axis and a low T(3) syndrome liothyron...	yes
Is the gene MAOA epigenetically modified by methylation?	converted_38	Is the gene MAOA protein, human epigenetically modified by methylation?	Evidence that the methylation state of the MAOA protein, human protein, human gene (MAOA protein, human protein, human) gene predicts brain activity of Monoamine Oxidase A Enzyme [APC] in healthy men. We found significant interindividual differences in methylation status and methylation patterns of the core MAOA protei...	yes
Is glycyl-tRNA synthetase gene involved in the development of Charcot-Marie-Tooth disease?	converted_39	Is Glycine-tRNA Ligase Genes involved in the development of Charcot-Marie-Tooth Disease?	Charcot-Marie-Tooth Disease type 2D (Charcot-Marie-Tooth Disease, Type 2D) is an autosomal-dominant axonal peripheral neuropathy characterized by impaired motor and sensory function in the distal extremities. Mutations in the Glycine-tRNA Ligase (GARS) Genes cause Charcot-Marie-Tooth Disease, Type 2D Dominant Gene Muta...	yes