id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 55 49.5k | label stringclasses 2
values |
|---|---|---|---|
converted_2602 | Is Rucaparib effective for ovarian cancer? | INTERPRETATION: In patients with BRCA mutant or BRCA wild-type and LOH high platinum-sensitive ovarian carcinomas treated with rucaparib, progression-free survival was longer than in patients with BRCA wild-type LOH low carcinomas., High LOH is associated with response to the PARP inhibitor rucaparib in BRCA wild-type ... | yes |
converted_3523 | Is SATB1 positioned close to AT-rich sequences? | Tryptic cleavage and peptide sequence analysis demonstrated that the 98-kD protein is identical to a recently cloned protein, special A-T-rich binding protein 1 (SATB1), Special AT-rich sequence-binding protein 1 (SATB1), a DNA-binding protein expressed predominantly in thymocytes, recognizes an ATC sequence context t... | yes |
converted_3810 | Can AGY be used as antidiuretic replacement therapy? | AGY, a Novel Egg Yolk-Derived Anti-gliadin Antibody, Is Safe for Patients with Celiac Disease., Oral egg yolk anti-gliadin antibody (AGY) is a novel treatment to neutralize gluten and may improve the efficacy of the GFD., To determine the safety, tolerability, and potential efficacy of AGY in patients with CD., Most pa... | no |
converted_1883 | Is there any tool that facilitates the functional analysis of cis-regulatory regions in zebrafish? | Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish., he cis-regulatory sequences control when, where, and how much genes are transcribed and can activate (enhancers) or repress (silencers) gene expression. Here, we describe... | yes |
converted_3335 | Does BNN27 promote memory loss? | The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficits in rats., BNN27 is a novel 17C spiroepoxy-DHEA derivative, which devoid of steroidogenic activity. The neuroprotective effects of BNN27 have been recently reported. The present study ... | no |
converted_4483 | Is resistance training usually associated with increasing muscle hypertrophy? | While traditional resistance exercises have been widely used to promote muscle strength and hypertrophy in the elderly, , These findings suggest that in young untrained men, progressing from a training frequency of once per week to a training frequency of 5 times per week with equated volume produces similar gains in ... | yes |
converted_2735 | Is Cystatin D a biomarker? | Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury.[SEP]Definitions: traumatic brain injury defined as following: A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.. Cystatin D defined as following: This gene is involved in the inhibition of cat... | yes |
converted_1176 | Is there an association between serum interleukin-6 concentrations and outcomes of stroke patients? | In addition, IL-6 concentrations affect clinical outcomes in ischemic stroke., After appropriate adjustment, the odds ratios for the association of markers and poor outcome (comparing the upper and the lower third) were interleukin-6, 3.1 (95% CI: 1.9-5.0); C-reactive protein, 1.9 (95% CI: 1.2-3.1); fibrinogen, 1.5 (9... | yes |
converted_4416 | Is periampullary carcinoma (PAC) a relatively rare genitourinary malignancy | Pancreaticobiliary subtype of Periampullary carcinoma (PAC) has a poor prognosis in comparison to the intestinal subtype., MUC1, CK20, and CDX2 immunohistochemical markers can sub-classify periampullary carcinomas into pancreaticobiliary, intestinal, and mixed subtypes., Pancreaticoduodenectomy (PD) is a complex surgic... | no |
converted_3545 | Does the BRAFV600E mutation have an effect on clinical response to radioiodine therapy? | Preclinical studies showed that BRAF mutation significantly reduced radioiodine uptake and decreased the sensitivity to radioactive iodine (RAI) therapy., The status of BRAF mutation may not affect the clinical response to RAI therapy for patients with PTMC with intermediate-risk to high-risk features. More trials exam... | yes |
converted_3928 | Is the Apis mellifera genome available? | Mining Apis mellifera sequences made it possible to identify the honey bee subspecies both at the mitochondrial and nuclear genome levels., Honey bee research is believed to be influenced dramatically by colony collapse disorder (CCD) and the sequenced genome release in 2006, but this assertion has never been tested.,... | yes |
converted_4273 | Is tofacitinib a JAK inhibitor? | The Janus Kinase inhibitor tofacitinib impacts human dendritic cell differentiation and favours M1 macrophage development., Tofacitinib, a small JAK inhibitor, is approved for the treatment of RA and has demonstrated good efficacy in psoriasis phase III clinical trials. [SEP]Definitions: JAK defined as following: A fam... | yes |
converted_3849 | Can ATAC-Seq be employed in single-cell mode? | Single-cell ATAC-seq: strength in numbers., Assembly, and Single-Cell ATAC-Seq., Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement., Here, we comprehensively characterize mouse cardiac progenitor cells (CPCs) marked by Nkx2-5 and Isl1 expression from E7.5 to ... | yes |
converted_3114 | Is there any association between suicide and autism in adolescents, yes or no? | : In all subjects from our research on PubMed, 21.3% of subjects with autism spectrum disorder reported suicidal ideation, have attempted suicide or died by suicide (115 out of 539 subjects) and 7.7% of subjects supported for suicidal thoughts or attempted suicide exhibited an autism spectrum disorder (62 out of 806 su... | yes |
converted_437 | Is there a role for the cylindromatosis tumor suppressor (CYLD) in lung cancer? | Over-expressing CYLD augments antitumor activity of TRAIL by inhibiting the NF-κB survival signaling in lung cancer cells, increased expression of CYLD directly blocks TRAIL-induced NF-κB activation, and consequently increases TRAIL-induced apoptosis in lung cancer cells. CYLD may act as a therapeutic target of lung ca... | yes |
converted_4213 | Is capmatinib effective for glioblastoma? | CONCLUSION: The combination of INC280/buparlisib resulted in no clear activity in patients with recurrent PTEN-deficient glioblastoma. [SEP]Definitions: glioblastoma defined as following: The most malignant astrocytic tumor (WHO grade 4). It is composed of poorly differentiated neoplastic astrocytes and is characterize... | no |
converted_1242 | Is nimodipine recommended for prevention of vasospasm in aneurysmal subarachnoid hemorrhage patients? | This article discusses some of these unresolved issues, including the use of medications such as nimodipine, antifibrinolytics, statins, and magnesium; coiling or clipping for aneurysm securement; and the prevention and treatment of potential complications., The results of this study were as follows: nimodipine demonst... | yes |
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