id stringlengths 11 14 | sentence1 stringlengths 21 192 | sentence2 stringlengths 55 47.4k | label stringclasses 2
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converted_381 | Is cadasil syndrome a hereditary disease? | CADASIL is the most frequent hereditary small-vessel disease of the brain. The clinical impact of various MR imaging markers has been repeatedly studied in this disorder, but alterations of contrast between gray matter and normal-appearing white matter remain unknown. The aim of this study was to evaluate the contrast... | yes |
converted_4032 | Is G3BP1 found in stress granules? | RAS GTPase-activating protein-binding protein (G3BP1) is an RNA-binding protein that is essential for assembling stress granules. , Within SGs, single-molecule localization microscopy revealed distributed hotspots of immobilized G3BP1 and IMP1 that reflect the presence of relatively immobile nanometer-sized nanocores.,... | yes |
converted_169 | Are there any specific antidotes for rivaroxaban? | Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of intracerebral hemorrhage (ICH). However, two facts make this situation complicated: First, the risk of hematoma expansion is unknown for NOACs. Second, there is no specific antidote for neither of the NOACs., ... | no |
converted_2571 | Can gas vesicles be detected by ultrasound? | Gas vesicles-genetically encoded protein nanostructures isolated from buoyant photosynthetic microbes-have recently been identified as nanoscale reporters for ultrasound., Here, we demonstrate that genetic engineering of gas vesicles results in nanostructures with new mechanical, acoustic, surface, and functional prope... | yes |
converted_2784 | Is there any association between the human gut microbiome and depression? | Moreover, recent findings are suggestive of the possibility that dysregulation of the enteric microbiota (i.e., dysbiosis) and associated bacterial translocation across the intestinal epithelium may be involved in the pathophysiology of stress-related psychiatric disorders, particularly depression.[SEP]Definitions: hum... | yes |
converted_2877 | Can enasidenib be used for the treatment of acute myeloid leukemia? | In August 2017, the United States Federal Drug Administration (FDA) approved enasidenib (Idhifa, Celgene/Agios) for adults with relapsed and refractory acute myelogenous leukemia (AML) with an IDH2 mutation. [SEP]Definitions: AML defined as following: Clonal expansion of myeloid blasts in bone marrow, blood, and other ... | yes |
converted_3791 | Do nematodes contain a CTCF gene? | Our findings show that CTCF and possibly chromatin insulation are present in basal nematodes. We suggest that the insulator protein CTCF has been secondarily lost in derived nematodes like C. elegans., The most highly enriched motif (LM1) corresponds to the X-box motif known from yeast and nematode. , show that three ... | yes |
converted_1695 | Is calcium overload involved in the development of diabetic cardiomyopathy? | High-glucose treatment resulted in increased intracellular calcium ([Ca2+]i) which was mobilized to the mitochondria. Concomitant intra-mitochondrial calcium ([Ca2+]m) increase resulted in enhanced reactive oxygen and nitrogen species generation. These events led to mitochondrial dysfunction and apoptosis., The novel f... | yes |
converted_3736 | Is αCGRP a member of the CGRP family? | αCGRP, another amyloidogenic member of the CGRP family., Therefore, in this work, we investigated the amyloidogenic profile of αCGRP, a 37-residue-long peptide hormone, utilizing both biophysical experimental techniques and Molecular Dynamics simulations. These efforts unravel a novel amyloidogenic member of the CGRP f... | yes |
converted_188 | Is there any link between CTF4 and CTF18 during sister chromatid cohesion? | Our results suggest that Elg1, Ctf4, and Ctf18 may coordinate the relative movement of the replication fork with respect to the cohesin ring, These data defined two cohesion pathways, one containing CSM3, TOF1, CTF4, and CHL1, and the second containing MRC1, CTF18, CTF8, and DCC1, Here we show that three proteins requi... | yes |
converted_4178 | Do bacteria release extracellular vesicles? | Bacterial extracellular vesicles (EVs) are bilayered lipid membrane structures, bearing integral proteins and able to carry diverse cargo outside the cell to distant sites., Knowledge of the structure, molecular cargo and function of bacterial extracellular vesicles (BEVs) is primarily obtained from bacteria cultured i... | yes |
converted_523 | Is stop codon bypass possible? | In 1999, proof-of-concept for treating these disorders was obtained in a mouse model of muscular dystrophy, when administration of aminoglycosides restored protein translation by inducing the ribosome to bypass a PTC., Aminoglycosides can bypass nonsense mutations and are the prototypic agents for translational bypass ... | yes |
converted_3248 | Is endotrophin derived from collagen? | endotrophin production from type IV collagen, High levels of COL6A3 and its cleaved product, endotrophin (ETP), Endotrophin is released from COL VI[SEP]Definitions: COL6A3 defined as following: Collagen alpha-3(VI) chain (3177 aa, ~344 kDa) is encoded by the human COL6A3 gene. This protein plays a role in extracellular... | yes |
converted_2129 | Is diphosphatidylglycerol (cardiolipin) a phospholipid of the mitochondrial membranes? | A unique organelle for studying membrane biochemistry is the mitochondrion whose functionality depends on a coordinated supply of proteins and lipids. Mitochondria are capable of synthesizing several lipids autonomously such as phosphatidylglycerol, cardiolipin and in part phosphatidylethanolamine, phosphatidic acid an... | yes |
converted_1467 | Are BRAF mutations common in melanoma? | patients with BRAF-mutant melanoma., BRAF-mutated melanoma , The RAS/RAF/MEK/ERK pathway has been reported to be activated in over 80% of all cutaneous melanomas, making it the focus of many scientific studies in the melanoma field. Discoveries of mutations and aberrant expression of components in this cascade, in part... | yes |
converted_2590 | Does temsirolimus improve survival of glioblastoma patients? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
converted_1414 | Are genes symmetrically distributed between leading and lagging DNA strand in bacteria? | Genomic DNA is used as the template for both replication and transcription, whose machineries may collide and result in mutagenesis, among other damages. Because head-on collisions are more deleterious than codirectional collisions, genes should be preferentially encoded on the leading strand to avoid head-on collision... | no |
converted_2408 | Was saracatinib being considered as a treatment for Alzheimer's disease in November 2017? | A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease., Herein, we present a Phase Ib trial of the repurposed investigational drug AZD0530, a Src family kinase inhibitor specific for Fyn and Src kinase, for the treat... | yes |
converted_1283 | Is factor XI deficient in Hemophilia C? | Factor XI deficiency is a rare hematologic disorder. Hemophilia C (factor XI deficiency) affects both genders and it is usually asymptomatic,, Congenital factor XI deficiency (also known as the Rosenthal syndrome or hemophilia C), rare case of an acute cerebral aneurysm rupture in a patient with a known factor XI defic... | yes |
converted_4100 | Are synonymous sites in primates and rodents functionally constrained? | To resolve this contradiction between expectations and observations, we used processed pseudogenes as a model for strict neutral evolution, and estimated selective constraint on synonymous sites using the rate of substitution at pseudosynonymous and pseudononsynonymous sites in pseudogenes as the neutral expectation. A... | no |
converted_162 | Is there an increased risk for cancer in Dyskeratosis Congenita? | People with DC are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML), solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis, Clinical progression of the disease can lead to aplastic anemi... | yes |
converted_985 | Is JTV519 (K201) a potential drug for the prevention of arrhythmias? | We compared the suppressive effect of K201 (JTV519), a multiple-channel blocker and cardiac ryanodine receptor-calcium release channel (RyR2) stabilizer, with that of diltiazem, a Ca(2+ )channel blocker, in 2 studies of isoproterenol-induced (n = 30) and ischemic-reperfusion-induced VAs (n = 38) in rats. , After admini... | yes |
converted_1530 | Does triiodothyronine stimulate red blood cell sodium potassium pump? | reduction in Na+,K+ATPase activity has been demonstrated in red blood cells (RBCs), as well as an inverse correlation between this enzymatic action and free triiodothyronine (FT3) levels., The restoration of normal FT3 values also brings about a normalization of Na+,K+ATPase activity in erythrocytes., at hyperthyroid p... | no |
converted_4578 | Is the protein HOXA11 associated with endometrial disease? | Both CD10 and HOXA11 have been implicated in regulation of endometrial homeostasis., Combined expression of HOXA11 and CD10 identifies endometriosis versus normal tissue and tumors., The combination of HOXA11 and CD10 expression profiles provides a useful tool to identify ectopic endometrial tissue and for distinguish... | yes |
converted_2141 | Is osteocrin expressed exclusively in the bone? | Evolution of Osteocrin as an activity-regulated factor in the primate brain., Here we use transcriptional profiling of human fetal brain cultures to identify an activity-dependent secreted factor, Osteocrin (OSTN), that is induced by membrane depolarization of human but not mouse neurons., Osteocrin (Ostn) is a recentl... | no |
converted_319 | Is microRNA(miRNA) 29 involved in post-ischemic cardiac remodeling? | Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and myocardial dysfunction. I, In addition, miR-21, -24, -133, -210, -494, and -499 appear to protect myocytes against I/R-induced apoptosis, whereas mi... | yes |
converted_4711 | Can METTL3 methylate long noncoding RNAs? | METTL3-Mediated lncRNA m6A Modification in the Osteogenic Differentiation of Human Adipose-Derived Stem Cells Induced by NEL-Like 1 Protein., This study aimed to explore the regulatory mechanism of methyltransferase3 (METTL3) -mediated long non-coding RNA (lncRNA) N6-methyladenosine (m6A) modification in the osteogenic... | yes |
converted_1775 | Is exon skipping correlated with exon circularization? | Exon Skipping Is Correlated with Exon Circularization, We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regulatory complexity of the human transcriptome, Exon Skipping Is Correlated with Exon Circularization., We find that circularization of ... | yes |
converted_703 | Is there an association between FGFR3 mutation and plagiocephaly? | Series of neurosurgical interventions were carried out, principally for acrocephaly and posterior plagiocephaly. The most common achondroplasia mutation, a p.Gly380Arg in the fibroblast growth factor receptor 3 (FGFR3) gene, was detected. , The most common mutation for achondroplasia (FGFR3 Gly380Arg, resulting in 113... | yes |
converted_677 | Are there any urine biomarkers for bladder cancer diagnosis? | CONCLUSIONS: Several gene-based urinary biomarkers have demonstrated promise in initial studies, which now need to be rigorously validated in the clinical setting for them to be translated into clinically useful tests in diagnosis, surveillance or risk-stratification of bladder cancer, Novel promising markers are in v... | yes |
converted_3174 | Was stelara developed by Amgen? | NICE does not specifically recommend switching from one biologic to another, and only ustekinumab (UST; STELARA®, Janssen Pharmaceuticals, Inc., Horsham, PA, USA) is recommended after anti-tumour necrosis factor failure.[SEP]Definitions: Janssen Pharmaceuticals defined as following: A pharmaceutical company providing m... | no |
converted_2357 | Is Kummell’s disease an avascular necrosis of the vertebral body? | Kummell's disease is an avascular necrosis of the vertebral body, secondary to a vertebral compression fracture. This entity is characterised by the gradual development in time of a vertebral body collapse following a trivial spinal trauma, involving a worsening back pain associated with a progressive kyphosis., Kumme... | yes |
converted_62 | Is pregnancy an additional risk during during H1N1 infection? | H1N1 influenza in pregnancy can be associated with severe complications, This case series confirms a high number of complications in pregnant women due to pandemic H1N1/09., Pregnant women might be at increased risk for complications from pandemic H1N1 virus infection., Pregnant women are at increased risk for complica... | yes |
converted_4546 | Is METTL1 overexpression associated with better patient survival? | Here we find METTL1 is frequently amplified and overexpressed in cancers and is associated with poor patient survival. METTL1 depletion causes decreased abundance of m7G-modified tRNAs and altered cell cycle and inhibits oncogenicity. Conversely, METTL1 overexpression induces oncogenic cell transformation and cancer. ... | no |
converted_691 | Do lincRNAs play a role in human cancer? | Long non-coding RNA H19 increases bladder cancer metastasis, These data suggest that upregulated H19 enhances bladder cancer metastasis by associating with EZH2 and inhibiting E-cad expression, lncRNA H19 is essential for human tumor growth, Previous reports have demonstrated that HOTAIR associates with chromatin modif... | yes |
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