original_question stringlengths 21 192 | id stringlengths 11 14 | sentence1 stringlengths 23 217 | sentence2 stringlengths 90 53.6k | label stringclasses 2
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Is glycyl-tRNA synthetase gene involved in the development of Charcot-Marie-Tooth disease? | converted_159 | Is glycyl-tRNA synthetase gene involved in the development of Charcot-Marie-Tooth Disease? | Charcot-Marie-Tooth Disease, Type 2D (CMT2D) is an autosomal-dominant axonal peripheral Neuropathy characterized by impaired motor and sensory function in the distal extremities. Gene Mutation in the glycyl-tRNA synthetase (GARS) gene cause CMT2D, Dominant mutations in GARS cause rare forms of Charcot-Marie-Tooth Disea... | yes |
Does triiodothyronine play a regulatory role in insulin secretion from pancreas? | converted_1619 | Does triiodothyronine play a regulatory role in Therapeutic Insulin secretion from pancreas? | Our findings establish that H3P31 gene is an important regulator of Glucose measurement homeostasis and pancreatic β-cell function and provide evidence for the first time of a physiological role for a mitochondrial endocrine receptor., The H3P31 gene(-/-) CASP14 gene had a major defect in Therapeutic Insulin secretion ... | yes |
Is propranolol used for treatment of infantile hemangioma? | converted_2315 | Is propranolol used for treatment of Infantile Hemangioma? | Low-Dose Treatment propranolol for Infantile Hemangioma of the head and neck: Analysis of 23 consecutive patients., BACKGROUND: More and more infantile hemangiomas (HEMIHYPERPLASIA, ISOLATED) are being treated with propranolol, but the effectiveness, dosage, and treatment course are still in dispute., CONCLUSIONS: Low-... | yes |
Does amiodarone affect thyroid hormone receptors in the myocardium? | converted_1092 | Does amiodarone affect thyroid hormone receptors in the myocardium? | ATF7IP wt Allele and Dron affected Tricuspid Valve Insufficiency expression in the Rheumatoid Arthritis similarly by decreasing TRalpha 1 and beta 1 expression by about 50%, In the LVW, ATF7IP wt Allele and Dron decreased THRB gene and, interestingly, ATF7IP wt Allele increased TRalpha 1., n the apex, ATF7IP wt Allele ... | yes |
Is the consumption of chocolate associated with an increase in cardiovascular disease? | converted_2552 | Is the consumption of Theobroma cacao, CALCOCO1 gene, chocolate associated with an increase in Cardiovascular Diseases? | The consumption of natural polyphenols-rich foods, and CALCOCO1 gene in particular, has been related to a reduced risk of Cerebrovascular Disorders, including coronary heart disease and Cerebrovascular accident., Theobroma cacao, CALCOCO1 gene, Theobroma cacao, CALCOCO1 gene, chocolate has been shown to decrease Cerebr... | no |
Is PUVA therapy indicated for eczema treatment? | converted_2056 | Is Methoxsalen With Ultraviolet A Therapy therapy indicated for Eczema treatment? | With bath Methoxsalen With Ultraviolet A Therapy treatment, the best results were found in patients with hyperkeratotic Eczema (17/22; 77% good clinical response) followed by patients with palmoplantar Psoriasis (26/41; 63%) and patients with Vesicular Eczema of Hand and/or feet (8/16; 50%). , Oral vs. bath Methoxsalen... | yes |
Can chronological age be predicted by measuring telomere length? | converted_1380 | Can chronological age be predicted by measuring telomere length? | Homo sapiens somatic cells gradually lose telomeric repeats with age. This study investigated if one could use a correlation between telomere length and age, to predict the age of an individual from their DNA., Therefore, telomere length measurement by real-time quantitative PCR cannot be used to predict age of a perso... | no |
Is vemurafenib used for thyroid cancer? | converted_2072 | Is vemurafenib used for Malignant neoplasm of thyroid? | vemurafenib in patients with BRAF protein, human protein, human(V600E)-positive metastatic or unresectable papillary Malignant neoplasm of thyroid refractory to radioactive Iodine, Homeopathic preparation: a non-randomised, multicentre, open-label, phase 2 trial., vemurafenib, an oncogenic BRAF protein, human protein, ... | yes |
Does GC content vary markedly within a given isochore? | converted_766 | Does GC content vary markedly within a given isochore? | The isochore, a large DNA Sequence - ParameterizedDataType with relatively small GC variance, is one of the most important structures in eukaryotic genomes., Isochores are large regions of relatively homogeneous nucleotide composition, Vertebrate genomes are comprised of isochores that are relatively long (>100 kb) reg... | no |
Is dasatinib effective for treatment of glioblastoma? | converted_2282 | Is dasatinib effective for treatment of Glioblastoma Multiforme? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 Cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
Is lenvatinib effective for thyroid cancer? | converted_1255 | Is lenvatinib effective for Malignant neoplasm of thyroid? | New insights in the treatment of iodide ion I-131 refractory differentiated Thyroid carcinoma: to lenvatinib and beyond., However, even more impressive responses and progression-free survival benefits were seen in the phase III SELECT trial with lenvatinib, giving even higher hopes for the future management of what was... | yes |
Is there any involvement of the long non-coding RNA Gomafu in schizophrenia? | converted_1964 | Is there any involvement of the long non-coding RNA MIAT gene in schizophrenia? | The long non-coding RNA MIAT gene is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing., Here, we profile these transcriptomic responses and show that long non-coding RNAs (lncRNAs) are dynamically regulated by neuronal activation, including acute downreg... | yes |
Are mucin overexpression associated with disease? | converted_3996 | Are Homo sapiens MUC1 protein overexpression associated with disease? | The pathological mechanism underlying Liver calculus is closely related to bacterial infections of the Intrahepatic bile duct, followed by chronic inflammation and the overexpression of Homo sapiens MUC1 wt Allele protein 5AC (MUC5AC protein, human protein, Homo sapiens)., MUC1 wt Allele wt Allele is a Membrane Glycopr... | yes |
Does HER2 under-expression lead to favorable response to trastuzumab? | converted_1267 | Does ERBB2 wt Allele under-expression lead to favorable response to trastuzumab? | over-expression of ERBB2 wt Allele is reported in approximately 20% of gastric tumours, challenging the use of targeted therapies. , In patients with advanced gastric or gastro-oesophageal junction cancer, addition of trastuzumab to chemotherapy significantly improved overall survival compared with chemotherapy alone. ... | no |
Does simvastatin improve outcomes of aneurysmal subarachnoid hemorrhage? | converted_2866 | Does simvastatin improve outcomes of aneurysmal subarachnoid hemorrhage? | Randomized controlled trials have shown that simvastatin and intravenous Magnesium supplements, alimentary tract and metabolism do not prevent Noninfiltrating Intraductal Carcinoma or improve functional outcomes after aneurysmal subarachnoid hemorrhage (ASAH1 wt Allele)., Conclusions Simvastatin showed no benefits in d... | no |
Does ESN364 activate the hypothalamic-pituitary-gonadal axis? | converted_3708 | Does ESN364 activate the hypothalamic-pituitary-gonadal axis? | Oral administration of the TACR3 wt Allele antagonist, ESN364, suppressed the hypothalamic-pituitary-gonadal axis in healthy volunteers by selective modulation of gonadotropin secretion, leading to a restrained decrease in ovarian hormone levels in women.[SEP]Definitions: TACR3 wt Allele defined as following: Human TAC... | no |
Is pimavanserin a typical antipsychotic? | converted_3448 | Is pimavanserin a typical antipsychotic? | pimavanserin is the first FDA-approved atypical antipsychotic drug indicated for the treatment of Hallucinations and Delusions associated with Parkinson Disease psychosis (Osteoarthropathy, Primary Hypertrophic).[SEP]Relations: pimavanserin has relations: drug_drug with Pirenzepine, drug_drug with Pirenzepine, drug_dru... | no |
Is Melioidosis caused by the bacterium Burkholderia pseudomallei? | converted_2063 | Is Melioidosis caused by the bacterium Pseudomonas pseudomallei antibody? | Pseudomonas pseudomallei antibody, the causative agent of Melioidosis,, What drives the occurrence of the Melioidosis bacterium Pseudomonas pseudomallei antibody in domestic gardens?, Landscape changes influence the occurrence of the Melioidosis bacterium Pseudomonas pseudomallei antibody in soil in northern Australia.... | yes |
Is deletion at 6q24.2-26 associated with longer survival of patients with high-grade serous ovarian carcinoma (HGSOCs)? | converted_3024 | Is Gene Deletion Abnormality at 6q24.2-26 associated with longer survival of patients with high-grade serous ovarian carcinoma (HGSOCs)? | Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients., We found that loss at 6q24.2-26 was significantly associated with the cluster of longer survival independently from other confounding factors (HR = 0.06, 95%CI = 0.01-0.43, Padj = 0.005). The prognostic value of thi... | yes |
Do raspberries improve postprandial glucose and acute and chronic inflammation in adults with type 2 Diabetes? | converted_2930 | Do raspberries improve postprandial glucose and acute and chronic inflammation in adults with type 2 Diabetes? | The NLR family pyrin domain containing 3 (NLRP3) inflammasome plays a critical role in insulin resistance and the pathogenesis of type 2 diabetes. Red raspberry (Retinoblastoma) contains high amounts of Dietary Fiber and polyphenolic compounds, which are known for their anti-oxidative and anti-inflammatory effects. [SE... | yes |
Is SLC22A3 expressed in the brain? | converted_146 | Is SLC22A3 expressed in the Head>Brain? | The Solute Carrier Family 22 Member 1 (OCT) 3 is widely expressed in various Organ in Homo sapiens, and involved in the disposition of many exogenous and endogenous compounds. Several lines of evidence have suggested that POU5F1 gene expressed in the Head>Brain plays an important role in the regulation of neurotransmis... | yes |
The TRPM2 gene is associated with development of spontaneous thromboembolism? | converted_2670 | The CLU gene gene is associated with development of spontaneous thromboembolism? | TheTransientReceptorPotentialMelastatin 2 (CLU gene) is a member of G protein coupled receptor superfamily and a novel dual-function protein that possesses both Ion Channel andAdenosine 5'-DiphosPhataseRibose (ADPR) hydrolase function. CLU gene is involved in calcium ionsignaling in various Cells as an endogenous redox... | no |
Can canagliflozin cause euglycemic diabetic ketoacidosis? | converted_2476 | Can canagliflozin cause euglycemic diabetic Ketoacidosis? | CASE REPORT: We present a case of a 57-year-old Human, Female adult with DIABETES MELLITUS, NONINSULIN-DEPENDENT, 1 (disorder) taking a combination of canagliflozin and metformin who presented with progressive altered mental status over the previous 2 days. Her work-up demonstrated a Metabolic acidosis with an anion ga... | yes |
Is Rucaparib effective for ovarian cancer? | converted_2602 | Is rucaparib effective for ovarian cancer? | INTERPRETATION: In patients with BRCA mutant or BRCA wild-type and Loss of Heterozygosity high Platinum-Sensitive Disease ovarian carcinomas treated with rucaparib, progression-free survival was longer than in patients with BRCA wild-type Loss of Heterozygosity low carcinomas., High Loss of Heterozygosity is associated... | yes |
Does strenuous physical activity affect thyroid hormone metabolism? | converted_154 | Does strenuous physical activity affect Thyroid Hormones metabolism? | The results of the present study in a unique experimental human model of maximal exposure to altitude and physical exercise demonstrate that extreme HA and strenuous physical exercise are coupled with specific endocrine adaptations. These include increased activity of the GH/IGF-I axis and a low T(3) syndrome, 3,5,3'-l... | yes |
Are astrocytes part of the blood brain barrier? | converted_3263 | Are Astrocytes part of the blood Head>Brain barrier? | The Blood - Head>Brain barrier function (BBB) is a tight boundary formed between Endothelial Cells and Astrocytes, which separates and protects Head>Brain from most pathogens as well as neural toxins in circulation., The Blood - Head>Brain barrier function (BBB) consists of Endothelial Cells, Astrocytes, and Pericytes ... | yes |
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