original_question stringlengths 21 192 | id stringlengths 11 14 | sentence1 stringlengths 23 217 | sentence2 stringlengths 90 53.6k | label stringclasses 2
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Is glycyl-tRNA synthetase gene involved in the development of Charcot-Marie-Tooth disease? | converted_159 | Is glycyl-tRNA synthetase gene involved in the development of Charcot-Marie-Tooth Disease? | Charcot-Marie-Tooth Disease, Type 2D (CMT2D) is an autosomal-dominant axonal peripheral Neuropathy characterized by impaired motor and sensory function in the distal extremities. Gene Mutation in the glycyl-tRNA synthetase (GARS) gene cause CMT2D, Dominant mutations in GARS cause rare forms of Charcot-Marie-Tooth Disea... | yes |
Does triiodothyronine play a regulatory role in insulin secretion from pancreas? | converted_1619 | Does triiodothyronine play a regulatory role in Therapeutic Insulin secretion from pancreas? | Our findings establish that H3P31 gene is an important regulator of Glucose measurement homeostasis and pancreatic β-cell function and provide evidence for the first time of a physiological role for a mitochondrial endocrine receptor., The H3P31 gene(-/-) CASP14 gene had a major defect in Therapeutic Insulin secretion ... | yes |
Is propranolol used for treatment of infantile hemangioma? | converted_2315 | Is propranolol used for treatment of Infantile Hemangioma? | Low-Dose Treatment propranolol for Infantile Hemangioma of the head and neck: Analysis of 23 consecutive patients., BACKGROUND: More and more infantile hemangiomas (HEMIHYPERPLASIA, ISOLATED) are being treated with propranolol, but the effectiveness, dosage, and treatment course are still in dispute., CONCLUSIONS: Low-... | yes |
Does amiodarone affect thyroid hormone receptors in the myocardium? | converted_1092 | Does amiodarone affect thyroid hormone receptors in the myocardium? | ATF7IP wt Allele and Dron affected Tricuspid Valve Insufficiency expression in the Rheumatoid Arthritis similarly by decreasing TRalpha 1 and beta 1 expression by about 50%, In the LVW, ATF7IP wt Allele and Dron decreased THRB gene and, interestingly, ATF7IP wt Allele increased TRalpha 1., n the apex, ATF7IP wt Allele ... | yes |
Is the consumption of chocolate associated with an increase in cardiovascular disease? | converted_2552 | Is the consumption of Theobroma cacao, CALCOCO1 gene, chocolate associated with an increase in Cardiovascular Diseases? | The consumption of natural polyphenols-rich foods, and CALCOCO1 gene in particular, has been related to a reduced risk of Cerebrovascular Disorders, including coronary heart disease and Cerebrovascular accident., Theobroma cacao, CALCOCO1 gene, Theobroma cacao, CALCOCO1 gene, chocolate has been shown to decrease Cerebr... | no |
Is PUVA therapy indicated for eczema treatment? | converted_2056 | Is Methoxsalen With Ultraviolet A Therapy therapy indicated for Eczema treatment? | With bath Methoxsalen With Ultraviolet A Therapy treatment, the best results were found in patients with hyperkeratotic Eczema (17/22; 77% good clinical response) followed by patients with palmoplantar Psoriasis (26/41; 63%) and patients with Vesicular Eczema of Hand and/or feet (8/16; 50%). , Oral vs. bath Methoxsalen... | yes |
Can chronological age be predicted by measuring telomere length? | converted_1380 | Can chronological age be predicted by measuring telomere length? | Homo sapiens somatic cells gradually lose telomeric repeats with age. This study investigated if one could use a correlation between telomere length and age, to predict the age of an individual from their DNA., Therefore, telomere length measurement by real-time quantitative PCR cannot be used to predict age of a perso... | no |
Is vemurafenib used for thyroid cancer? | converted_2072 | Is vemurafenib used for Malignant neoplasm of thyroid? | vemurafenib in patients with BRAF protein, human protein, human(V600E)-positive metastatic or unresectable papillary Malignant neoplasm of thyroid refractory to radioactive Iodine, Homeopathic preparation: a non-randomised, multicentre, open-label, phase 2 trial., vemurafenib, an oncogenic BRAF protein, human protein, ... | yes |
Does GC content vary markedly within a given isochore? | converted_766 | Does GC content vary markedly within a given isochore? | The isochore, a large DNA Sequence - ParameterizedDataType with relatively small GC variance, is one of the most important structures in eukaryotic genomes., Isochores are large regions of relatively homogeneous nucleotide composition, Vertebrate genomes are comprised of isochores that are relatively long (>100 kb) reg... | no |
Is dasatinib effective for treatment of glioblastoma? | converted_2282 | Is dasatinib effective for treatment of Glioblastoma Multiforme? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 Cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
Is lenvatinib effective for thyroid cancer? | converted_1255 | Is lenvatinib effective for Malignant neoplasm of thyroid? | New insights in the treatment of iodide ion I-131 refractory differentiated Thyroid carcinoma: to lenvatinib and beyond., However, even more impressive responses and progression-free survival benefits were seen in the phase III SELECT trial with lenvatinib, giving even higher hopes for the future management of what was... | yes |
Is there any involvement of the long non-coding RNA Gomafu in schizophrenia? | converted_1964 | Is there any involvement of the long non-coding RNA MIAT gene in schizophrenia? | The long non-coding RNA MIAT gene is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing., Here, we profile these transcriptomic responses and show that long non-coding RNAs (lncRNAs) are dynamically regulated by neuronal activation, including acute downreg... | yes |
Are mucin overexpression associated with disease? | converted_3996 | Are Homo sapiens MUC1 protein overexpression associated with disease? | The pathological mechanism underlying Liver calculus is closely related to bacterial infections of the Intrahepatic bile duct, followed by chronic inflammation and the overexpression of Homo sapiens MUC1 wt Allele protein 5AC (MUC5AC protein, human protein, Homo sapiens)., MUC1 wt Allele wt Allele is a Membrane Glycopr... | yes |
Does HER2 under-expression lead to favorable response to trastuzumab? | converted_1267 | Does ERBB2 wt Allele under-expression lead to favorable response to trastuzumab? | over-expression of ERBB2 wt Allele is reported in approximately 20% of gastric tumours, challenging the use of targeted therapies. , In patients with advanced gastric or gastro-oesophageal junction cancer, addition of trastuzumab to chemotherapy significantly improved overall survival compared with chemotherapy alone. ... | no |
Does simvastatin improve outcomes of aneurysmal subarachnoid hemorrhage? | converted_2866 | Does simvastatin improve outcomes of aneurysmal subarachnoid hemorrhage? | Randomized controlled trials have shown that simvastatin and intravenous Magnesium supplements, alimentary tract and metabolism do not prevent Noninfiltrating Intraductal Carcinoma or improve functional outcomes after aneurysmal subarachnoid hemorrhage (ASAH1 wt Allele)., Conclusions Simvastatin showed no benefits in d... | no |
Does ESN364 activate the hypothalamic-pituitary-gonadal axis? | converted_3708 | Does ESN364 activate the hypothalamic-pituitary-gonadal axis? | Oral administration of the TACR3 wt Allele antagonist, ESN364, suppressed the hypothalamic-pituitary-gonadal axis in healthy volunteers by selective modulation of gonadotropin secretion, leading to a restrained decrease in ovarian hormone levels in women.[SEP]Definitions: TACR3 wt Allele defined as following: Human TAC... | no |
Is pimavanserin a typical antipsychotic? | converted_3448 | Is pimavanserin a typical antipsychotic? | pimavanserin is the first FDA-approved atypical antipsychotic drug indicated for the treatment of Hallucinations and Delusions associated with Parkinson Disease psychosis (Osteoarthropathy, Primary Hypertrophic).[SEP]Relations: pimavanserin has relations: drug_drug with Pirenzepine, drug_drug with Pirenzepine, drug_dru... | no |
Is Melioidosis caused by the bacterium Burkholderia pseudomallei? | converted_2063 | Is Melioidosis caused by the bacterium Pseudomonas pseudomallei antibody? | Pseudomonas pseudomallei antibody, the causative agent of Melioidosis,, What drives the occurrence of the Melioidosis bacterium Pseudomonas pseudomallei antibody in domestic gardens?, Landscape changes influence the occurrence of the Melioidosis bacterium Pseudomonas pseudomallei antibody in soil in northern Australia.... | yes |
Is deletion at 6q24.2-26 associated with longer survival of patients with high-grade serous ovarian carcinoma (HGSOCs)? | converted_3024 | Is Gene Deletion Abnormality at 6q24.2-26 associated with longer survival of patients with high-grade serous ovarian carcinoma (HGSOCs)? | Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients., We found that loss at 6q24.2-26 was significantly associated with the cluster of longer survival independently from other confounding factors (HR = 0.06, 95%CI = 0.01-0.43, Padj = 0.005). The prognostic value of thi... | yes |
Do raspberries improve postprandial glucose and acute and chronic inflammation in adults with type 2 Diabetes? | converted_2930 | Do raspberries improve postprandial glucose and acute and chronic inflammation in adults with type 2 Diabetes? | The NLR family pyrin domain containing 3 (NLRP3) inflammasome plays a critical role in insulin resistance and the pathogenesis of type 2 diabetes. Red raspberry (Retinoblastoma) contains high amounts of Dietary Fiber and polyphenolic compounds, which are known for their anti-oxidative and anti-inflammatory effects. [SE... | yes |
Is SLC22A3 expressed in the brain? | converted_146 | Is SLC22A3 expressed in the Head>Brain? | The Solute Carrier Family 22 Member 1 (OCT) 3 is widely expressed in various Organ in Homo sapiens, and involved in the disposition of many exogenous and endogenous compounds. Several lines of evidence have suggested that POU5F1 gene expressed in the Head>Brain plays an important role in the regulation of neurotransmis... | yes |
The TRPM2 gene is associated with development of spontaneous thromboembolism? | converted_2670 | The CLU gene gene is associated with development of spontaneous thromboembolism? | TheTransientReceptorPotentialMelastatin 2 (CLU gene) is a member of G protein coupled receptor superfamily and a novel dual-function protein that possesses both Ion Channel andAdenosine 5'-DiphosPhataseRibose (ADPR) hydrolase function. CLU gene is involved in calcium ionsignaling in various Cells as an endogenous redox... | no |
Can canagliflozin cause euglycemic diabetic ketoacidosis? | converted_2476 | Can canagliflozin cause euglycemic diabetic Ketoacidosis? | CASE REPORT: We present a case of a 57-year-old Human, Female adult with DIABETES MELLITUS, NONINSULIN-DEPENDENT, 1 (disorder) taking a combination of canagliflozin and metformin who presented with progressive altered mental status over the previous 2 days. Her work-up demonstrated a Metabolic acidosis with an anion ga... | yes |
Is Rucaparib effective for ovarian cancer? | converted_2602 | Is rucaparib effective for ovarian cancer? | INTERPRETATION: In patients with BRCA mutant or BRCA wild-type and Loss of Heterozygosity high Platinum-Sensitive Disease ovarian carcinomas treated with rucaparib, progression-free survival was longer than in patients with BRCA wild-type Loss of Heterozygosity low carcinomas., High Loss of Heterozygosity is associated... | yes |
Does strenuous physical activity affect thyroid hormone metabolism? | converted_154 | Does strenuous physical activity affect Thyroid Hormones metabolism? | The results of the present study in a unique experimental human model of maximal exposure to altitude and physical exercise demonstrate that extreme HA and strenuous physical exercise are coupled with specific endocrine adaptations. These include increased activity of the GH/IGF-I axis and a low T(3) syndrome, 3,5,3'-l... | yes |
Are astrocytes part of the blood brain barrier? | converted_3263 | Are Astrocytes part of the blood Head>Brain barrier? | The Blood - Head>Brain barrier function (BBB) is a tight boundary formed between Endothelial Cells and Astrocytes, which separates and protects Head>Brain from most pathogens as well as neural toxins in circulation., The Blood - Head>Brain barrier function (BBB) consists of Endothelial Cells, Astrocytes, and Pericytes ... | yes |
Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
cause sudden cardiac death? | converted_825 | Could Catecholaminergic Polymorphic Ventricular Tachycardia (Polymorphic catecholergic Ventricular Tachycardia by ECG Finding)
cause Sudden Cardiac Death? | Two siblings died suddenly at the ages of 9 and 10 years, Catecholaminergic Polymorphism Ventricular Tachycardia by ECG Finding (Polymorphic catecholergic Ventricular Tachycardia by ECG Finding) is a type of Cardiac Arrhythmia that occurs in people with a structurally normal Chest>Heart. Stress or anxiety-induced relea... | yes |
Is the UGT1A1*28 polymorphism associated with irinotecan response in Caucasians? | converted_1430 | Is the UGT1A1*28 Allele polymorphism associated with irinotecan response in Caucasians? | These Variant are associated with greater risk of serious Toxic effect., Homozygous carriers of UGT1A1*28 Allele Allele as well as those with additional UGT1A1 wt Allele Variant can suffer from severe irinotecan Toxic effect[SEP]Relations: Irinotecan has relations: drug_protein with UGT1A1, drug_protein with UGT1A1, dr... | yes |
Is NADPH oxidase 5 expressed in rodents? | converted_1778 | Is NADPH oxidase 5 expressed in Rodent? | Because the Nox5 gene is absent in Rodent, we generated Mice, Transgenic expressing human Nox5 in a podocyte-specific manner (Nox5(pod+)). , The NADPH oxidase 5 (NOX5) gene is present in Homo sapiens but not Rodent. , The data document that the NOX5 gene was expressed in Cells of Lagomorpha unlike Rodent, making the ra... | no |
Does replication timing affect the rate of somatic mutations? | converted_888 | Does replication timing affect the rate of somatic Gene Mutation? | Here we observe that Mutation Abnormality rate, as reflected in recent evolutionary divergence and human nucleotide diversity, is markedly increased in later-replicating regions of the human Genome - anatomical entity, ll classes of substitutions are affected, suggesting a generalized mechanism involving replication ti... | yes |
Is SATB1 expressed in thymocytes? | converted_3649 | Is DNA-Binding Protein SATB1 expressed in thymocyte? | A thymocyte factor DNA-Binding Protein DNA-Binding Protein SATB1 suppresses transcription of stably integrated matrix-attachment region-linked reporter Genes., DNA-Binding Protein DNA-Binding Protein SATB1 is a Homeodomain Proteins and is predominantly expressed in thymocyte. , DNA-Binding Protein DNA-Binding Protein S... | yes |
Is Apelin usually decreased in diabetes? | converted_3157 | Is APLN gene usually decreased in Diabetes Mellitus? | APLN gene has been shown to act on Glucose measurement and lipid metabolism but also to modulate insulin secretion. Moreover, different studies in both animal allergen extracts and Homo sapiens have shown that plasma APLN protein, human concentrations are usually increased during BODY MASS INDEX QUANTITATIVE TRAIT LOCU... | no |
Does wheat belongs to the genus Avena, yes or no? | converted_2517 | Does Triticum aestivum belongs to the genus Avena, yes or no? | oat seedlings (oats preparation), wild green-oat (oats preparation) , ornithine-oxo-acid aminotransferase activity (oats preparation L.), ornithine-oxo-acid aminotransferase activity (oats preparation L.), Avena (oat allergenic extract), oats preparation, oatstraw, Avena sativa, oatstraw, wild oats (Avena fatua L.), o... | no |
Does radiation for tinea capitis increases brain tumor risk? | converted_3445 | Does radiation for Tinea Capitis increases Brain Neoplasms risk? | Emphasis is placed on Meningioma resulting from childhood treatment for primary Brain Neoplasms or Tinea Capitis, exposure to dental x-rays, and exposure to atomic explosions in Hiroshima and Nagasaki. , It is well known that radiation can induce Meningioma. These Neoplasms usually arise in patients with a history of L... | yes |
Is Brucella abortus the organism that causes brucillosis known to cause spontaneous abortions in humans? | converted_2721 | Is Brucella species abortus the organism that causes brucillosis known to cause spontaneous Abortions:Number:Point in time:^Patient:Quantitative:Reported in Homo sapiens? | . Brucellosis is a major cause of Fever of unknown origin (Pyrexia of unknown origin (excl puerperal)), Brucellosis is the most common Bacterial Zoonoses, and causes a considerable burden of Disease in endemic countries. Cardiovascular involvement is the main cause of mortality due to Communicable Diseases with Brucell... | no |
Can fetal aneuploidy be detected with non-invasive prenatal testing? | converted_876 | Can Prenatal care aneuploidy be detected with non-invasive prenatal testing? | Non-invasive prenatal testing with cell-free DNA: US physician attitudes toward implementation in clinical practice., The aim of this study was to assess awareness, potential adoption, and current utilization of non-invasive prenatal testing (NIPT) analysis for common Prenatal care aneuploidies among obstetricians, Cel... | yes |
Can the Micro-C XL method achieve mononucleosome resolution? | converted_1845 | Can the Micro-C XL method achieve mononucleosome resolution? | We present Micro-C XL, an improved method for analysis of chromosome folding at mononucleosome resolution, We present Micro-C XL, an improved method for analysis of chromosome folding at mononucleosome resolution., Micro-C XL: assaying chromosome conformation from the nucleosome location location to the entire Genome -... | yes |
Is Bladder training an effective method to treat urge incontinence ? | converted_705 | Is Bladder training an effective method to treat urge Incontinence ? | Mindfulness-based stress reduction appears to be a treatment worthy of further study, as in the short term, it is as effective as historical studies of Pharmacologic Substance treatment and Urinary Bladder training in reducing urge Incontinence and Incontinence-related quality of life., All patients, irrespective of th... | yes |
Is there any functional association during viral replication between flaviviridae viral RNA depended RNA polymerase and viral helicase? | converted_836 | Is there any functional association during viral replication between flaviviridae viral RNA depended RNA polymerase and viral helicase? | Several labs have obtained evidence for a Protein complex that involves many of the nonstructural (NS) Proteins encoded by the Virus. NOONAN SYNDROME 3, NS4A, NS4B, NS5A, and NS5B appear to interact structurally and functionally. In this study, we investigated the interaction between the helicase, NOONAN SYNDROME 3, an... | yes |
Is insulin-like growth factor-I (IGF-I) able to affect tendon protein synthesis in classic Ehlers-Danlos syndrome patients? | converted_764 | Is Insulin-Like Growth Factor I (IGF-I) able to affect tendon protein synthesis in classic Ehlers-Danlos syndrome patients? | Tendon protein synthesis rate in classic Ehlers-Danlos patients can be stimulated with Insulin-Like Growth Factor I, IGF-I injections significantly increased Flexed Sidebent Rotated values in Autoimmune Lymphoproliferative Syndrome Type 2B patients but not in controls, In conclusion, baseline protein synthesis rates in... | yes |
Can pazopanib be used for treatment von Hippel-Lindau disease? | converted_3048 | Can pazopanib be used for treatment Von Hippel-Lindau Syndrome? | Variable response of Clinical Nurse Specialists hemangioblastomas to pazopanib in a single patient with Von Hippel-Lindau Syndrome: Case report., Treatment of Renal Cell Carcinoma with Protein-tyrosine kinase inhibitor (disposition) (TKIs) such as pazopanib is now first line therapy, but their effect on VHL-associated ... | yes |
Are Crocus sativus compounds being considered against Alzheimer's disease? | converted_3184 | Are Crocus sativus antigen compounds being considered against ALZHEIMER DISEASE, FAMILIAL, 1? | Previous evidence suggested that Crocus sativus antigen antigen is linked to improving cognitive function in ALZHEIMER DISEASE, FAMILIAL, 1 (cytarabine/daunorubicin protocol) patients. The aim of this study was to in vitro and in vivo investigate the mechanism(s) by which Crocus sativus antigen antigen exerts its posit... | yes |
Does MVIIA and MVIIC bind to the same calcium channel? | converted_1434 | Does MVIIA and MVIIC bind to the same calcium channel? | We examined the post-pubertal behavioral effects of neonatal (postnatal day 7) medial prefrontal Adrenal Cortex Diseases infusion of either vehicle or N-type and P/Q-type presynaptic voltage-dependent calcium channel blockers (ziconotide and MVIIC respectively; 6.8 and 45 pmol infused respectively) in Rattus norvegicus... | no |
Is Weaver syndrome similar to Sotos? | converted_47 | Is Weaver syndrome similar to Sotos? | Overgrowth conditions are a heterogeneous group of disorders characterised by increased growth and variable features, including Macrocephaly, distinctive facial appearance and various degrees of Learning difficulties and Intellectual Disability. Among them, Sotos and Weaver syndromes are clinically well defined and due... | yes |
Are proteasome inhibitors good candidates for treatment of leukemia and solid tumors? | converted_187 | Are Proteasome inhibitors, antineoplastic agent good candidates for treatment of leukemia and solid Neoplasms? | We show that treatment with b-AP15 inhibited tumor progression in four different in vivo Solid Neoplasm models and inhibited organ infiltration in an RUNX1 gene model. Our results show that the deubiquitinating activity of the 19S regulatory particle is a new anticancer drug target, We further found that ATO targets Mi... | yes |
Is there alternative polyadenylation during zebrafish development? | converted_1878 | Is there alternative polyadenylation during Zebrafish development? | Extensive alternative polyadenylation during Zebrafish development., At 2 h post-fertilization, thousands of unique poly(A) sites appear at locations lacking a typical polyadenylation signal, which suggests a wave of widespread cytoplasmic polyadenylation of mRNA degradation intermediates. Our insights into the identit... | yes |
Does International Citicoline Trial on acUte Stroke trial supports efficacy of citicoline for stroke treatment? | converted_2658 | Does International Citicoline Trial on acUte Stroke trial supports efficacy of citicoline for Cerebrovascular accident treatment? | The meta-analysis showed that no significant differences were found in the long-term mortality (OR=0.91, 95% CI 0.07 to 1.09, P=0.30), the rate of dependency (OR=1.02, 95% CI 0.87 to 1.24, P=0.85), and the effective rate (OR=0.98, 95% CI 0.84 to 1.14, P=0.82) between citicoline group and control group. , In conclusion... | no |
Does the BRAFV600E mutation have an effect on clinical response to radioiodine therapy? | converted_3545 | Does the BRAFV600E Mutation Abnormality have an effect on clinical response to iodide ion I-131 therapy? | Preclinical studies showed that BRAF protein, human protein, human Mutation Abnormality significantly reduced iodide ion I-131 uptake and decreased the sensitivity to radioactive iodine (PPP1R13L wt Allele) therapy., The status of BRAF protein, human protein, human Mutation Abnormality may not affect the clinical respo... | yes |
Is mitofusin 2 a receptor for parkin? | converted_1733 | Is MFN2 gene a receptor for parkin? | Recent work demonstrates that a phosphorylated form of the mitochondrial fusion protein Mitofusin 2 serves as a receptor for Parkin translocation to damaged Mitochondria., We show that the mitochondrial outer membrane guanosine triphosphatase mitofusin (Mfn) 2 mediates Parkin recruitment to damaged Mitochondria. , Mfn2... | yes |
Is GRG5 involved only in late embryonic mouse development? | converted_3556 | Is TLE5 gene involved only in late embryonic Mus sp. development? | Groucho related gene 5 (TLE5 gene) is a HSD17B4 gene that has been implicated in late embryonic and postnatal Mus sp. development. Here, we describe a previously unknown role of TLE5 gene in early developmental stages by analyzing its function in stem cell fate decisions. By both loss and gain of function approaches we... | no |
Is cadasil syndrome a hereditary disease? | converted_381 | Is cadasil syndrome a hereditary disease? | NOTCH3 wt Allele is the most frequent hereditary small-vessel disease of the Head>Brain. The clinical impact of various MR imaging markers has been repeatedly studied in this disorder, but alterations of contrast between gray matter and normal-appearing white matter remain unknown. The aim of this study was to evaluat... | yes |
Does dronedarone affect T3 and T4 levels? | converted_1452 | Does dronedarone affect T3 thoracic segmental innervation and T4 levels? | Amiodarone resulted in increased T4, T4/T3 thoracic segmental innervation thoracic segmental innervation and rT3, whereas dronedarone did not alter the Thyroid Hormones profile in normal animals., Fifty-five Wistar rats were randomly allocated to a 2-week oral treatment with either vehicle (n=18), amiodarone (30 mg/kg,... | no |
Can epigenetic modifications be heritable? | converted_4444 | Can epigenetic modifications be heritable? | Epigenetic alterations (epimutations) could thus contribute to heritable variation within populations and be subject to evolutionary processes such as natural selection and drift. [SEP] | yes |
Are cyclophilins proteins that bind to prolines? | converted_297 | Are cyclophilins Proteins that bind to prolines? | Cyclophilins are ubiquitously expressed Proteins that bind to prolines and can catalyse CISH protein, human/trans isomerization of proline residues., a characteristic of the cyclophilin family of Proteins that bind prolines and often act as CISH protein, human-trans peptidyl-prolyl isomerases. , The cyclophilins are wi... | yes |
Is STAT3 transcription factor regulated by mTORC1? | converted_1691 | Is STAT3 protein, human transcription factor regulated by mechanistic target of rapamycin complex 1? | Mechanistically, mechanistic target of rapamycin complex 1 mediated IL-6-induced Stat3 activation in intestinal Epithelial Cells to stimulate the expression of downstream targets essential for cell proliferation and tissue regeneration. Therefore, mechanistic target of rapamycin complex 1 signaling critically protects ... | yes |
Has depression been shown to be a predictor of frailty? | converted_220 | Has depression been shown to be a predictor of frailty? | significant role of frailty as a predictor of depression in a relatively younger old Chinese population, significant relationships between frailty and Depressive Symptoms and mortality at 1 year, These findings suggest that Malnutrition is a major predictor of frailty or the "failure to thrive" syndrome in older person... | yes |
Is invasion and metastasis one of the hallmarks of cancer? | converted_431 | Is invasion and metastasis one of the hallmarks of cancer? | The pathogenesis of millimeter involves the accumulation of extensive cytogenetic changes, as well as cancer-related phenotypic alterations that facilitate Tumor cells, uncertain whether benign or malignant survival, invasion and metastasis. This review presents current knowledge regarding the biological characteristic... | yes |
Does molindone affect body weight? | converted_618 | Does molindone affect body weight? | Mean weight increased by 0.54 kg, and mean body mass index by 0.24 kg/m(2). , A large-scale trial comparing a first-generation antipsychotic (molindone) with newer agents did not find significant differences in treatment response, although the newer antipsychotics were associated with more severe weight gain. , No agen... | yes |
Is MEDI2228 a bispecific antibody? | converted_4357 | Is MEDI2228 a bispecific antibody? | We here delineated the Molecular and cellular mechanisms underlying novel immunomodulatory effects triggered by BCMA pyrrolobenzodiazepine (PBD) antibody drug conjugate (ADC) MEDI2228 which can augment efficacy of these immunotherapies.[SEP]Relations: Molecular system has relations: anatomy_anatomy with gABAergic syste... | no |
Is cystatin C or cystatin 3 used as a biomarker of kidney function? | converted_874 | Is CST3 gene or cystatin 3 used as a biomarker of kidney function? | to explore the effect of ageing on renal function with CST3 gene as the marker of glomerular filtration rate (GFR) in the general population without Vascular Diseases or Diabetes Mellitus., Cystatin C, a more specific kidney function biomarker, was also elevated at 24 h after CLP., This study evaluated FGF-23 as well a... | yes |
Is phospholamban phosphorylated by Protein kinase A? | converted_572 | Is phospholamban phosphorylated by Protein kinase A? | cAMP-dependent protein kinase (PKA) phosphorylation of PLB1 gene, phosphorylation of PLN gene gene, at either Ser(16) by PKA , Activation of cardiac muscle Sarcoplasmic Reticulum Ca2+-ATPase (SERCA2a) by beta1-agonists involves cAMP- and PKA-dependent phosphorylation of phospholamban (PLB1 gene), which relieves the inh... | yes |
Is Selinexor effective for multiple myeloma? | converted_3484 | Is Selinexor effective for Multiple Myeloma? | Safety and efficacy of selinexor in relapsed or refractory Multiple Myeloma and Waldenstrom Macroglobulinemia., Based on these findings, we conclude that selinexor in combination with dexamethasone is active in heavily pretreated Millimole per Liter and propose a RP2D of 45 mg/m2 (80 mg) plus 20 mg dexamethasone given ... | yes |
Is it possible to detect survivin protein expression in normal human adult tissues? | converted_432 | Is it possible to detect survivin protein expression in normal Homo sapiens adult Body tissue? | BIRC5 protein, Homo sapiens wt Allele (BIRC5 protein, Homo sapiens protein, Homo sapiens) is one of the members of IAP-family apoptosis inhibitors. The BIRCS gene is expressed in most Homo sapiens embryonic Body tissue and Malignant Neoplasms but not in normal differentiated Body tissue of adult Homo sapiens., BIRC5 pr... | no |
Are astronauts in higher risk for developing cancer? | converted_3557 | Are astronauts in higher risk for developing cancer? | Understanding space radiation health effects is critical due to potential increased morbidity and mortality following spaceflight. , No significant associations between space radiation dose and mortality were found using logistic regression with an internal reference group, adjusting for medical radiation., Despite ye... | no |
Is sumoylation implicated in myogenesis? | converted_682 | Is sumoylation implicated in myogenesis? | Sentrin/small ubiquitin-like modifier (SUMO)-specific protease 2 (SUMO1 wt Allele) has broad de-SUMOylation activities in vitro, which is essential for embryonic heart development., Silencing SUMO1 wt Allele can reduce growth-differentiation factor 8 expression and, therefore, promote myogenesis of Specimen Source Code... | yes |
Are long non coding RNAs as conserved in sequence as protein coding genes? | converted_63 | Are long non coding RNAs as conserved in sequence as protein coding genes? | Most lncRNAs are under lower sequence constraints than protein-coding genes and lack conserved secondary structures, making it hard to predict them computationally., hey are under stronger selective pressure than neutrally evolving sequences-particularly in their Promoter Regions, Genetic, which display levels of selec... | no |
Is there any link between conserved noncoding elements and alternative splicing in vertebrates? | converted_1187 | Is there any link between conserved noncoding elements and alternative splicing in Vertebrates? | Some of the most highly conserved sequences occur in Genes encoding RNA-Binding Proteins, particularly the RNA splicing-associated SR Genes. Differences in sequence conservation between Plants and animal allergen extracts are likely to reflect differences in the biology of the Organism, with Plants being much more able... | yes |
Are microRNA (miR) regulated through DNA methylation of their promoters? | converted_1369 | Are MicroRNAs (miR) regulated through DNA methylation of their promoters? | We found that TCF7L1 gene down-regulation in the context of constitutively active Wnt signaling does not result from Promoter DNA methylation but is likely to be caused by a plethora of mechanisms at both the RNA and protein level as shown by the observed decrease in activating histone marks (histone H3 trimethyl Lys4 ... | yes |
Does low T3 negatively affect prognosis of patients after cardiac surgery? | converted_1567 | Does low T3 thoracic segmental innervation negatively affect prognosis of patients after cardiac surgery? | ur findings suggest that the development of LCOS after congenital heart surgery is associated with decreased total and free T3 thoracic segmental innervation thoracic segmental innervation, and increased interleukin-8 receptor binding activity levels at 48 hours, and preoperative Adenosine A2B Receptor Antagonist TT-4 ... | yes |
Are there microbes in human breast milk? | converted_2779 | Are there microbes in human Breast Milk Specimen? | Contrary to long-held dogma, human Milk Specimen is not sterile. Instead, it provides infants a rich source of diverse Bacteria, particularly microbes belonging to the Staphylococcus, Streptococcus species species, and Pseudomonas genera., The origins of the Bacteria in Milk Specimen are thought to include the maternal... | yes |
Does nintedanib hold promise for lung disease associated with systemic sclerosis? | converted_3480 | Does nintedanib hold promise for lung disease associated with Systemic Scleroderma? | The patient developed progressive lung Fibrosis under several immunosuppressants and was started on nintedanib, with clinical and functional stabilization. Nintedanib is a tyrosine-kinase PPP1R1A gene that blocks several profibrotic pathways, inhibiting proliferation and migration of Specimen Source Codes - Fibroblasts... | yes |
Is Downs syndrome associated with decreased risk of leukemia? | converted_2227 | Is Down Syndrome associated with decreased risk of leukemia? | The association of Down's syndrome and leukemia has been documented for over 50 years. Multiple studies have established the incidence of leukemia in Down's syndrome patients to be 10- to 20-fold higher than that in the general population., We present a case of congenital Leukemia, Myelocytic, Acute manifesting from th... | no |
Is tirabrutinib effective for lymphoma? | converted_4628 | Is tirabrutinib effective for lymphoma? | In March 2020, oral tirabrutinib was approved in Japan for the treatment of recurrent or refractory primary central nervous system lymphoma. tirabrutinib is also under regulatory review in Japan for the treatment of Waldenström's macroglobulinemia and Malignant lymphoma - lymphoplasmacytic. Clinical development is unde... | yes |
Are there ultraconserved genomic regions in the budding yeast? | converted_2270 | Are there ultraconserved genomic regions in the budding yeast? | Here, we present a systematic study of ultraconserved genomic regions in the budding yeast based on the publicly available genome sequences, in order to reveal their relationship with the adaptability or fitness advantages of the budding yeast.Results: Our results indicate that, in addition to some fundamental biologic... | yes |
Is Lysozyme abundant in human tears? | converted_4261 | Is muramidase abundant in human tears? | LYZL2 gene present in the natural tear, muramidase (LYZL2 gene C, human) is a naturally occurring Enzyme [APC] that operates against Gram-positive bacteria and leads to cell death. This antimicrobial Enzyme [APC] forms the part of the innate defense system of nearly all animal allergen extracts and exists in their soma... | yes |
Does epidural anesthesia for pain management during labor affect the Apgar score of the the infant? | converted_2844 | Does epidural anesthesia for pain management during labor affect the Apgar score of the the infant? | We retrospectively analyzed 93 consecutive single-pregnancy patients who underwent cesarean section with combined spinal-epidural anesthesia. The patients were divided into two groups, depending on the use of 6% Idiopathic Hypereosinophilic Syndrome 130/0.4: group A (461 ± 167 ml of saline-based Idiopathic Hypereosino... | no |
Is acid alpha-glucosidase the enzyme that causes Pompe disease when mutant? | converted_725 | Is acid Alpha-glucosidase the Enzyme [APC] that causes Generalized glycogen storage disease of infants when Mutant? | Generalized glycogen storage disease of infants is an autosomal recessive genetic disorder characterized by a deficiency of the Enzyme [APC] responsible for degradation of lysosomal glycogen (acid α-glucosidase (Ga language)), Generalized glycogen storage disease of infants is a systemic metabolic disorder characterize... | yes |
Is G3BP1 found in stress granules? | converted_4032 | Is G3BP1 gene found in Stress Granules? | RAS GTPase-activating protein-binding protein (G3BP1 gene gene) is an RBMS3 gene that is essential for assembling Stress Granules. , Within Shprintzen-Goldberg syndrome, single-molecule localization microscopy revealed distributed hotspots of immobilized G3BP1 gene gene and IGF2BP1 gene that reflect the presence of rel... | yes |
Are there mammalian promoters with distal enhancer functions? | converted_2425 | Are there mammalian Promoter with distal Enhancer of transcription functions? | Genome-wide characterization of mammalian Promoter with distal Enhancer of transcription functions., Gene expression in Mammals is precisely regulated by the combination of Promoter and gene-distal Regulatory Sequences, Nucleic Acid, known as enhancers. Several studies have suggested that some Promoter might have Enhan... | yes |
Is FTY720 FDA approved? | converted_4263 | Is FTY-720 FDA approved? | FTY-720 (fingolimod) is a known sphingosine 1-phosphate (S1P) receptor Agonist that exerts strong anti-inflammatory effects and was approved as the first oral drug for the treatment of Multiple Sclerosis by the US Food and Drug Administration (FDA) in 2010. [SEP]Relations: fingolimod has relations: drug_drug with WIN 5... | yes |
Is Sotatercept effective for Pulmonary Arterial Hypertension? | converted_4419 | Is Sotatercept effective for Pulmonary Arterial Hypertension? | Sotatercept for the Treatment of Pulmonary Arterial Hypertension., CONCLUSIONS: Treatment with Sotatercept resulted in a reduction in pulmonary vascular resistance in patients receiving background therapy for Idiopathic Idiopathic pulmonary arterial hypertension., Sotatercept for the Treatment of Pulmonary Arterial Hyp... | yes |
Has the protein TIEG1 been associated with apoptosis? | converted_147 | Has the protein TIEG1 been associated with apoptosis? | Recombinant Transforming Growth Factor-Beta) inducible early gene 1 (TIEG1) is known to induce apoptosis in Recombinant Transforming Growth Factor-Beta sensitive pancreatic Tumor Cells, malignant, yet its effect on Recombinant Transforming Growth Factor-Beta resistant Tumor Cells, malignant remains unclear, overexpress... | yes |
Is erythropoietin effective for treatment of amyotrophic lateral sclerosis? | converted_2791 | Is erythropoietin effective for treatment of amyotrophic lateral sclerosis? | This study was performed to validate the Amyotrophic Lateral Sclerosis-MITOS as a 6-month proxy of survival in 200 Amyotrophic Lateral Sclerosis patients followed up to 18 months.METHODS: Analyses were performed on data from the recombinant human erythropoietin RCT that failed to demonstrate differences between groups ... | no |
Can desvenlafaxine be used at a dose of 50mg/day? | converted_1216 | Can desvenlafaxine be used at a dose of 50mg/day? | Long-term use of desvenlafaxine was safe and well tolerated, with a clinical benefit/risk profile similar to that in other populations., e objective of this study was to evaluate the long-term safety of desvenlafaxine for continuation treatment of major depressive disorder (Major Depressive Disorder) in Japanese patien... | yes |
Has the companion diagnostic HercepTest received FDA approval? | converted_4223 | Has the companion diagnostic HercepTest received FDA approval? | The FDA-Approved Breast Cancer HER2 Evaluation Kit (HercepTest; Dako) May Miss Some HER2-Positive Breast Cancers., HER2 fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) tests were performed on 52 cases using a US Food and Drug Administration (FDA)-approved kit (HercepTest, FDA kit) and a laborat... | yes |
Do RNA:DNA hybrids preferentially form in high or low GC regions? | converted_1392 | Do RNA:DNA hybrids preferentially form in high or low GC regions? | Intrinsic termination signals for multisubunit bacterial RNA polymerases (RNAPs) encode a GC-rich stem-loop structure followed by a polyuridine [poly(U)] tract, and it has been proposed that steric clash of the stem-loop with the exit pore of the RNAP imposes a shearing force on the RNA in the downstream RNA:DNA hybrid... | yes |
Is nucleosome eviction ATP-dependent? | converted_308 | Is nucleosome location eviction ATP-dependent? | ATP-dependent chromatin location location remodeling and nucleosome location location-depleted 'barriers' co-operate to determine the kinetics of nucleosome location location organization, ATP-dependent nucleosome location location-remodeling factors endow chromatin location location with structural flexibility by prom... | yes |
Is Huntington's disease is caused by expansion of a CTG repeat in the HTT gene on Chromosome 4? | converted_3531 | Is Huntington Disease is caused by expansion of a CTG repeat in the SLC6A4 wt Allele gene on Chromosome 4? | Huntington Disease (Hodgkin Disease) is caused by a CAG repeat expansion that encodes a polyglutamine (polyQ) expansion in the Hodgkin Disease disease Protein Info, Hodgkin Disease Protein Info, human (SLC6A4 wt Allele)., Huntington disease (Hodgkin Disease) is a dominantly inherited disorder caused by a CAG expansion ... | no |
Is amiodarone a class I anti-arrhythmic drug? | converted_142 | Is amiodarone a Canadian Cardiovascular Society Grading Scale Class I Antiarrhythmic [EPC] drug? | Common Canadian Cardiovascular Society Grading Scale Class I agents are excluded due to the inherent abnormal cardiac structure and function in the setting of Shock, Cardiogenic. Class III drug options include dofetilide and amiodarone., Amiodarone has been used as an Antiarrhythmic [EPC] drug since the 1970s and has a... | no |
Is metabolic syndrome related with cardiovascular disease? | converted_835 | Is Metabolic Syndrome X related with Cardiovascular Diseases? | The Metabolic Syndrome X (ETV3 wt Allele) is characterized by a cluster of risk factors including central obesity, Hypertensive disease, Dyslipidemias and insulin resistance, The ETV3 wt Allele is associated with an increased risk for Cardiovascular Diseases (Cerebrovascular Disorders) and type 2 diabetes mellitus (T2D... | yes |
Has amantadine ER been approved by the FDA? | converted_3583 | Has amantadine Endoplasmic Reticulum been approved by the FDA? | ADS-5102 (amantadine) extended-release (Endoplasmic Reticulum) capsules (GOCOVRITM) is a recent US FDA-approved treatment for Dyskinetic syndrome in Lugano Lymphoma Response Classification Progressive Disease by PET patients. [SEP]Relations: Amantadine has relations: drug_drug with Ergometrine, drug_drug with Ergometri... | yes |
Is there an association between FGFR3 mutation and plagiocephaly? | converted_703 | Is there an association between FGFR3 protein, human Mutation Abnormality and Plagiocephaly? | Series of neurosurgical interventions were carried out, principally for Acrocephaly and posterior Plagiocephaly. The most common Achondroplasia Mutation Abnormality, a p.Gly380Arg in the Fibroblast Growth Factor Receptors (FGFR3 protein, human protein, human) gene, was detected. , The most common Mutation Abnormality ... | yes |
Is ozanezumab effective for amyotrophic lateral sclerosis? | converted_3431 | Is ozanezumab effective for amyotrophic lateral sclerosis? | The adjusted mean of the joint-rank score was -14·9 (SE 13·5) for the ozanezumab group and 15·0 (13·6) for the placebo group, with a least squares mean difference of -30·0 (95% CI -67·9 to 7·9; p=0·12). , INTERPRETATION: Ozanezumab did not show efficacy compared with placebo in patients with Amyotrophic Lateral Scleros... | no |
Is the 22-item sino-nasal outcome test (SNOT-22) a widely used measure for Health-Related Quality-of-Life (HRQOL) associated with chronic rhinosinusitis (CRS)? | converted_4421 | Is the 22-item sino-nasal outcome test (SNOT-22) a widely used measure for Health-Related Quality-of-Life (HRQOL) associated with Chronic sinusitis (Congenital Rubella Syndrome)? | The Sino-Nasal-Outcome-Test-22 (SNOT-22) represents the reference questionnaire to assess symptoms, health-related quality-of-life (HRQOL) and treatment-response in patients with Chronic sinusitis (Congenital Rubella Syndrome). , Assessment of health-related quality-of-life in patients with chronic Rhinosinusitis - Val... | yes |
Are deletions of chromosomal regulatory boundaries associated with congenital disease? | converted_1843 | Are Gene Deletion of chromosomal regulatory boundaries associated with Congenital Disorders? | Deletions of chromosomal regulatory boundaries are associated with Congenital Disorders., Our results suggest that Enhancer of transcription adoption caused by Gene Deletion of regulatory boundaries may contribute to a substantial minority of copy-number variation phenotypes and should thus be taken into account in the... | yes |
SGOT is an abbreviation for an enzyme other wise known as alanine amino transferase, yes or no? | converted_2420 | SGOT - Glutamate oxaloacetate transaminase is an abbreviation for an enzyme other wise known as D-Alanine Transaminase, yes or no? | patients with aspartate amino transferase (SGOT - Glutamate oxaloacetate transaminase - Glutamate oxaloacetate transaminase), D-Alanine Transaminase (SGPT - Glutamate pyruvate transaminase - Glutamate pyruvate transaminase),, Alanine amino transferase (SGPT - Glutamate pyruvate transaminase - Glutamate pyruvate transam... | no |
Is Titin the largest single protein molecule found in Nature? | converted_1478 | Is Titin Kinase the largest single Protein Info molecule found in Nature? | Titin Kinase Kinase, the largest Protein Info in the Human body structure, is well known as a molecular spring in Muscle Cells and scaffold Protein Info aiding myofibrillar assembly., Titin Kinase Kinase is the largest Protein Info in Mammals; it forms an elastic filament along the myofibril of Cardiac - anatomy qualif... | yes |
Are Chernobyl survivors at increased risk for breast cancer? | converted_3695 | Are Chernobyl survivors at increased risk for Malignant neoplasm of Breast? | Results: A more aggressive course of Malignant neoplasm of Breast is observed in patients exposed to radiation from the Chernobyl accident under the age of 30 years (P < .01). , A significant excess of Multiple Myeloma incidence [standardized incidence rate (SIR) 1.61 %, 95% confidence interval (NDUFB6 gene) 1.01-2.21]... | yes |
Is istiratumab effective for pancreatic cancer? | converted_4300 | Is istiratumab effective for pancreatic cancer? | CONCLUSIONS: Istiratumab failed to improve the efficacy of SOC chemotherapy in this patient setting. [SEP]Definitions: pancreatic cancer defined as following: A primary or metastatic malignant tumor involving the pancreas. Representative examples include carcinoma and lymphoma.. | no |
Does oncogene-induced DNA replication stress inhibit genomic instability? | converted_2662 | Does oncogene-induced DNA replication stress inhibit genomic instability? | Oncogene-induced DNA replication stress is thought to drive genomic instability in Primary malignant neoplasm., We propose that single-stranded DNA generated in response to oncogene-induced replication stress compromises the repair of deaminated cytosines and other damaged Unit dose - Base, leading to the observed Symp... | no |
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