id stringlengths 11 14 | sentence1 stringlengths 20 168 | sentence2 stringlengths 55 47.4k | label stringclasses 2
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converted_1871 | Can NEECHAM Confusion Scale be used for evaluation of postoperative delirium? | Sampling was achieved in a nonrandomized targeted manner and delirium was assessed using NeeCham questionnaire. , Delirium in older patients: a diagnostic study of NEECHAM Confusion Scale in surgical intensive care unit., AIMS AND OBJECTIVES: To estimate the diagnostic value and determine the feasibility of the NEECHAM... | yes |
converted_665 | Has overexpression of sirtuins been reported to increase lifespan in budding yeast (Saccharomyces cerevisiae)? | In addition, Sir2 overexpression prevents Rif1 deletion from disrupting Sir2 at IGS1 and shortening lifespan. , Roles for sirtuin proteins at telomeres are thought to promote lifespan in yeast and mammals., Overexpression of sirtuins (NAD(+)-dependent protein deacetylases) has been reported to increase lifespan in budd... | yes |
converted_227 | Can DNA intercalators function as topoisomerase inhibitors? | The aporphine alkaloids (+)-dicentrine and (+)-bulbocapnine are non-planar molecules lacking features normally associated with DNA binding by intercalation or minor groove binding. Surprisingly, dicentrine showed significant activity as a topoisomerase II (EC 5.99.1.3) inhibitor and also was active in a DNA unwinding a... | yes |
converted_1281 | Is TNNI3K a cardiac-specific protein? | cardiomyocyte-specific kinase TNNI3K , We report that cardiac troponin I-interacting kinase (TNNI3K), a cardiomyocyte-specific kinase,, TNNI3K, a cardiac-specific kinase, , The cardiac troponin I-interacting kinase (TNNI3K), a novel cardiac specific kinase, is associated with cardiomyocyte hypertrophy, Human cardiac t... | yes |
converted_1045 | Is clathrin involved in E-cadherin endocytosis? | We demonstrated that GnT-III induced a stabilizing effect on E-cadherin at the cell membrane by inducing a delay in the turnover rate of the protein, contributing for the formation of stable and functional adherens-junctions, and further preventing clathrin-dependent E-cadherin endocytosis., Conversely, GnT-V promotes ... | yes |
converted_2587 | Are sleep apnea and snoring associated with cardiac arrhythmias? | Atrial fibrillation (AF) is the commonest arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Obstructive sleep apnea (OSA), a common breathing disorder, is an independent risk factor for AF., There is a growing consensus in the scientific community that suggests a s... | yes |
converted_3707 | Has MLE4901 been tested in phase III clinical trials? | METHODS
This phase 2, randomised, double-blind, placebo-controlled, single-centre, crossover trial assessed the effectiveness of an oral neurokinin 3 receptor antagonist (MLE4901) on menopausal hot flushes., Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double... | no |
converted_1615 | Are high-flow nasal cannulae effective for treatment of preterm infants? | The use of high-flow nasal cannulae is an increasingly popular alternative to nasal continuous positive airway pressure (CPAP) for noninvasive respiratory support of very preterm infants (gestational age, <32 weeks) after extubation., The use of high-flow nasal cannulae was noninferior to the use of nasal CPAP, with tr... | yes |
converted_2970 | Does allele phasing improve the phylogenetic utility of ultraconserved elements? | Allele Phasing Greatly Improves the Phylogenetic Utility of Ultraconserved Elements., Our empirical analyses of Ultraconserved Element (UCE) locus data collected from the South American hummingbird genus Topaza demonstrate that phased allele sequences carry sufficient phylogenetic information to infer the genetic struc... | yes |
converted_2186 | Can acupuncture cause spinal epidural hematoma? | RESULTS: A 54-year-old woman, a 38-year-old woman, and a 60-year-old man with hemiplegia by cervical subdural or epidural hematoma after cervical posterior paraspinal muscle needling without direct invasion (intramuscular stimulation, acupuncture, or intramuscular lidocaine) were observed., Acute spinal subdural hemato... | yes |
converted_3984 | Should minocycline be used for mild Alzheimer disease? | Conclusions and Relevance: Minocycline did not delay the progress of cognitive or functional impairment in people with mild AD during a 2-year period. [SEP]Definitions: Minocycline defined as following: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective agai... | no |
converted_1030 | Are DNA helicases involved in progeroid syndromes? | Among these syndromes, relevant advances have recently been made in Werner syndrome, one of several progeroid syndromes characterized by defective DNA helicases,, Progeroid syndromes (PSs) constitute a group of disorders characterized by clinical features mimicking physiological aging at an early age., However, all the... | yes |
converted_1828 | Is Migalastat used for treatment of Fabry Disease? | Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study., BACKGROUND: Fabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, resulting in α-galactosidase (α-Gal) deficiency and accumulatio... | yes |
converted_1876 | Has small pox been eradicated from the world? | small pox has been eradicated., smallpox is now eradicated, In May 1980 the World Health Assembly in Geneva announced in solemn form the world-wide eradication of the small-pox and gave recommendations to the member countries for concluding measures concerning the small-pox vaccination, the foundation of vaccine reserv... | yes |
converted_703 | Is there an association between FGFR3 mutation and plagiocephaly? | Series of neurosurgical interventions were carried out, principally for acrocephaly and posterior plagiocephaly. The most common achondroplasia mutation, a p.Gly380Arg in the fibroblast growth factor receptor 3 (FGFR3) gene, was detected. , The most common mutation for achondroplasia (FGFR3 Gly380Arg, resulting in 113... | yes |
converted_3655 | Does gavestinel improve outcomes of stroke patients? | CONCLUSION: Consistent with the clinical outcomes in the GAIN trials, no effects of gavestinel on ischemic infarction was observed., No effects of gavestinel on infarct volume were observed in the primary or other analyses. , Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the... | no |
converted_848 | Is there a pharmacogenetic test for trastuzumab? | The clinical need for novel approaches to improve drug therapy derives from the high rate of adverse reactions to drugs and their lack of efficacy in many individuals that may be predicted by pharmacogenetic testing., the assessment of the human epidermal growth factor receptor (HER-2) expression for trastuzumab therap... | yes |
converted_3205 | Does RUNX2 inhibit astrocyte differentiation? | The method was able to recapitulate experimentally validated cell-fate determinants, and validation of two predicted cell-fate determinants confirmed that overexpression of ESR1 and RUNX2 in mouse neural stem cells induces neuronal and astrocyte differentiation, respectively.[SEP]Definitions: RUNX2 defined as following... | no |
converted_895 | Does the histidine-rich Ca-binding protein (HRC) interact with triadin? | The HRC effects on RyR may be regulated by the Ca(2+)-sensitivity of its interaction with triadin., In rabbit skeletal and cardiac muscles, HRC binds to sarcoplasmic reticulum (SR) membranes via triadin, a junctional SR protein. , HRC may play a key role in the regulation of SR Ca cycling through its direct interaction... | yes |
converted_2620 | Is DNA polymerase θ involved in DNA repair? | DNA polymerase θ (Pol θ) is implicated in various cellular processes including double-strand break repair and apurinic/apyrimidinic site bypass., Pol θ is the defining enzyme for a pathway of DSB repair termed "alternative end-joining" (altEJ) or "theta-mediated end-joining.", DNA polymerase θ is a key player in PARP-... | yes |
converted_2721 | Is Brucella abortus the organism that causes brucillosis known to cause spontaneous abortions in humans? | . Brucellosis is a major cause of pyrexia of unknown origin (PUO), Brucellosis is the most common bacterial zoonosis, and causes a considerable burden of disease in endemic countries. Cardiovascular involvement is the main cause of mortality due to infection with Brucella spp,, quite abruptly, he developed asthenia and... | no |
converted_1138 | Does surgery for ovarian endometriomas improve fertility? | CONCLUSION: Endometriomas per se appear to be the main cause of the reduced long-term reproductive performance of the affected patients, with little or no contribution from surgery. Furthermore, endometrioma surgery seems to improve the success rates of fertility treatment., Amongst the 38 women desiring pregnancy afte... | yes |
converted_2461 | Does Evolocumab improve cognitive function? | Conclusions In a randomized trial involving patients who received either evolocumab or placebo in addition to statin therapy, no significant between-group difference in cognitive function was observed over a median of 19 months. , Results A total of 1204 patients were followed for a median of 19 months; the mean (±SD) ... | no |
converted_3708 | Does ESN364 activate the hypothalamic-pituitary-gonadal axis? | Oral administration of the NK3R antagonist, ESN364, suppressed the hypothalamic-pituitary-gonadal axis in healthy volunteers by selective modulation of gonadotropin secretion, leading to a restrained decrease in ovarian hormone levels in women.[SEP]Definitions: NK3R defined as following: Human TACR3 wild-type allele is... | no |
converted_2592 | Are there sex differences in the transcriptome of the mouse hippocampus? | To better understand the possible molecular basis for the sex-biased nature of neurological disorders, we used a developmental series of female and male mice at 1, 2, and 4 months of age to assess both mRNA and protein in the hippocampus with RNA-sequencing and mass-spectrometry, respectively., The bulk of these differ... | yes |
converted_4558 | Do mutations in KCNT2 only cause phenotypes with epilepsy? | KCNT2 variants resulting in substitutions affecting the Arg190 residue have been shown to cause epileptic encephalopathy and a recognizable facial gestalt. We report two additional individuals with intellectual disability, dysmorphic features, hypertrichosis, macrocephaly and the same de novo KCNT2 missense variants af... | no |
converted_867 | Are psammoma bodies characteristic to meningiomas? | Psammoma bodies (PBs) are concentric lamellated calcified structures, observed most commonly in papillary thyroid carcinoma (PTC), meningioma, and papillary serous cystadenocarcinoma of ovary but have rarely been reported in other neoplasms and nonneoplastic lesions., Studies on serous cystadenocarcinoma of ovary and m... | yes |
converted_856 | Is Dicer part of the RISC loading complex? | Dicer is a component of the protein machinery (the RNA Induced Silencing Complex [RISC]) which is involved in catalyzing the formation of mature microRNAs from their precursors in the process of microRNA biogenesis., RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor co... | yes |
converted_1287 | Can the apoptosis regulator BAX trigger the release of cytochrome c? | 6-Shogaol reduced the mitochondrial membrane potential (MMP) and released cytochrome c from mitochondria to cytosol via Bax activation. , Moreover, overexpression of ERβ prevented Bax activation, cytochrome c release, caspase-3 activation, and PARP cleavage during apoptosis., In this study, we demonstrated that EV71 in... | yes |
converted_1532 | Is selumetinib effective in thyroid cancer? | A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours., BACKGROUND: We completed a phase I clinical trial to test the safety and toxicity of combined treatment with cixutumumab (anti-IGF-1R antibody) and selu... | yes |
converted_882 | Is nivolumab used for treatment of Non–Small-Cell Lung Cancer? | BACKGROUND: Patients with advanced squamous-cell non-small-cell lung cancer (NSCLC) who have disease progression during or after first-line chemotherapy have limited treatment options. This randomized, open-label, international, phase 3 study evaluated the efficacy and safety of nivolumab, a fully human IgG4 programmed... | yes |
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