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converted_1871 | Can NEECHAM Confusion Scale be used for evaluation of postoperative delirium? | Sampling was achieved in a nonrandomized targeted manner and delirium was assessed using NeeCham questionnaire. , Delirium in older patients: a diagnostic study of NEECHAM Confusion Scale in surgical intensive care unit., AIMS AND OBJECTIVES: To estimate the diagnostic value and determine the feasibility of the NEECHAM... | yes |
converted_665 | Has overexpression of sirtuins been reported to increase lifespan in budding yeast (Saccharomyces cerevisiae)? | In addition, Sir2 overexpression prevents Rif1 deletion from disrupting Sir2 at IGS1 and shortening lifespan. , Roles for sirtuin proteins at telomeres are thought to promote lifespan in yeast and mammals., Overexpression of sirtuins (NAD(+)-dependent protein deacetylases) has been reported to increase lifespan in budd... | yes |
converted_227 | Can DNA intercalators function as topoisomerase inhibitors? | The aporphine alkaloids (+)-dicentrine and (+)-bulbocapnine are non-planar molecules lacking features normally associated with DNA binding by intercalation or minor groove binding. Surprisingly, dicentrine showed significant activity as a topoisomerase II (EC 5.99.1.3) inhibitor and also was active in a DNA unwinding a... | yes |
converted_1281 | Is TNNI3K a cardiac-specific protein? | cardiomyocyte-specific kinase TNNI3K , We report that cardiac troponin I-interacting kinase (TNNI3K), a cardiomyocyte-specific kinase,, TNNI3K, a cardiac-specific kinase, , The cardiac troponin I-interacting kinase (TNNI3K), a novel cardiac specific kinase, is associated with cardiomyocyte hypertrophy, Human cardiac t... | yes |
converted_1045 | Is clathrin involved in E-cadherin endocytosis? | We demonstrated that GnT-III induced a stabilizing effect on E-cadherin at the cell membrane by inducing a delay in the turnover rate of the protein, contributing for the formation of stable and functional adherens-junctions, and further preventing clathrin-dependent E-cadherin endocytosis., Conversely, GnT-V promotes ... | yes |
converted_2587 | Are sleep apnea and snoring associated with cardiac arrhythmias? | Atrial fibrillation (AF) is the commonest arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Obstructive sleep apnea (OSA), a common breathing disorder, is an independent risk factor for AF., There is a growing consensus in the scientific community that suggests a s... | yes |
converted_3707 | Has MLE4901 been tested in phase III clinical trials? | METHODS
This phase 2, randomised, double-blind, placebo-controlled, single-centre, crossover trial assessed the effectiveness of an oral neurokinin 3 receptor antagonist (MLE4901) on menopausal hot flushes., Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double... | no |
converted_1615 | Are high-flow nasal cannulae effective for treatment of preterm infants? | The use of high-flow nasal cannulae is an increasingly popular alternative to nasal continuous positive airway pressure (CPAP) for noninvasive respiratory support of very preterm infants (gestational age, <32 weeks) after extubation., The use of high-flow nasal cannulae was noninferior to the use of nasal CPAP, with tr... | yes |
converted_2970 | Does allele phasing improve the phylogenetic utility of ultraconserved elements? | Allele Phasing Greatly Improves the Phylogenetic Utility of Ultraconserved Elements., Our empirical analyses of Ultraconserved Element (UCE) locus data collected from the South American hummingbird genus Topaza demonstrate that phased allele sequences carry sufficient phylogenetic information to infer the genetic struc... | yes |
converted_2186 | Can acupuncture cause spinal epidural hematoma? | RESULTS: A 54-year-old woman, a 38-year-old woman, and a 60-year-old man with hemiplegia by cervical subdural or epidural hematoma after cervical posterior paraspinal muscle needling without direct invasion (intramuscular stimulation, acupuncture, or intramuscular lidocaine) were observed., Acute spinal subdural hemato... | yes |
converted_3984 | Should minocycline be used for mild Alzheimer disease? | Conclusions and Relevance: Minocycline did not delay the progress of cognitive or functional impairment in people with mild AD during a 2-year period. [SEP]Definitions: Minocycline defined as following: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective agai... | no |
converted_1030 | Are DNA helicases involved in progeroid syndromes? | Among these syndromes, relevant advances have recently been made in Werner syndrome, one of several progeroid syndromes characterized by defective DNA helicases,, Progeroid syndromes (PSs) constitute a group of disorders characterized by clinical features mimicking physiological aging at an early age., However, all the... | yes |
converted_1828 | Is Migalastat used for treatment of Fabry Disease? | Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study., BACKGROUND: Fabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, resulting in α-galactosidase (α-Gal) deficiency and accumulatio... | yes |
converted_1876 | Has small pox been eradicated from the world? | small pox has been eradicated., smallpox is now eradicated, In May 1980 the World Health Assembly in Geneva announced in solemn form the world-wide eradication of the small-pox and gave recommendations to the member countries for concluding measures concerning the small-pox vaccination, the foundation of vaccine reserv... | yes |
converted_703 | Is there an association between FGFR3 mutation and plagiocephaly? | Series of neurosurgical interventions were carried out, principally for acrocephaly and posterior plagiocephaly. The most common achondroplasia mutation, a p.Gly380Arg in the fibroblast growth factor receptor 3 (FGFR3) gene, was detected. , The most common mutation for achondroplasia (FGFR3 Gly380Arg, resulting in 113... | yes |
converted_3655 | Does gavestinel improve outcomes of stroke patients? | CONCLUSION: Consistent with the clinical outcomes in the GAIN trials, no effects of gavestinel on ischemic infarction was observed., No effects of gavestinel on infarct volume were observed in the primary or other analyses. , Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the... | no |
converted_848 | Is there a pharmacogenetic test for trastuzumab? | The clinical need for novel approaches to improve drug therapy derives from the high rate of adverse reactions to drugs and their lack of efficacy in many individuals that may be predicted by pharmacogenetic testing., the assessment of the human epidermal growth factor receptor (HER-2) expression for trastuzumab therap... | yes |
converted_3205 | Does RUNX2 inhibit astrocyte differentiation? | The method was able to recapitulate experimentally validated cell-fate determinants, and validation of two predicted cell-fate determinants confirmed that overexpression of ESR1 and RUNX2 in mouse neural stem cells induces neuronal and astrocyte differentiation, respectively.[SEP]Definitions: RUNX2 defined as following... | no |
converted_895 | Does the histidine-rich Ca-binding protein (HRC) interact with triadin? | The HRC effects on RyR may be regulated by the Ca(2+)-sensitivity of its interaction with triadin., In rabbit skeletal and cardiac muscles, HRC binds to sarcoplasmic reticulum (SR) membranes via triadin, a junctional SR protein. , HRC may play a key role in the regulation of SR Ca cycling through its direct interaction... | yes |
converted_2620 | Is DNA polymerase θ involved in DNA repair? | DNA polymerase θ (Pol θ) is implicated in various cellular processes including double-strand break repair and apurinic/apyrimidinic site bypass., Pol θ is the defining enzyme for a pathway of DSB repair termed "alternative end-joining" (altEJ) or "theta-mediated end-joining.", DNA polymerase θ is a key player in PARP-... | yes |
converted_2721 | Is Brucella abortus the organism that causes brucillosis known to cause spontaneous abortions in humans? | . Brucellosis is a major cause of pyrexia of unknown origin (PUO), Brucellosis is the most common bacterial zoonosis, and causes a considerable burden of disease in endemic countries. Cardiovascular involvement is the main cause of mortality due to infection with Brucella spp,, quite abruptly, he developed asthenia and... | no |
converted_1138 | Does surgery for ovarian endometriomas improve fertility? | CONCLUSION: Endometriomas per se appear to be the main cause of the reduced long-term reproductive performance of the affected patients, with little or no contribution from surgery. Furthermore, endometrioma surgery seems to improve the success rates of fertility treatment., Amongst the 38 women desiring pregnancy afte... | yes |
converted_2461 | Does Evolocumab improve cognitive function? | Conclusions In a randomized trial involving patients who received either evolocumab or placebo in addition to statin therapy, no significant between-group difference in cognitive function was observed over a median of 19 months. , Results A total of 1204 patients were followed for a median of 19 months; the mean (±SD) ... | no |
converted_3708 | Does ESN364 activate the hypothalamic-pituitary-gonadal axis? | Oral administration of the NK3R antagonist, ESN364, suppressed the hypothalamic-pituitary-gonadal axis in healthy volunteers by selective modulation of gonadotropin secretion, leading to a restrained decrease in ovarian hormone levels in women.[SEP]Definitions: NK3R defined as following: Human TACR3 wild-type allele is... | no |
converted_2592 | Are there sex differences in the transcriptome of the mouse hippocampus? | To better understand the possible molecular basis for the sex-biased nature of neurological disorders, we used a developmental series of female and male mice at 1, 2, and 4 months of age to assess both mRNA and protein in the hippocampus with RNA-sequencing and mass-spectrometry, respectively., The bulk of these differ... | yes |
converted_4558 | Do mutations in KCNT2 only cause phenotypes with epilepsy? | KCNT2 variants resulting in substitutions affecting the Arg190 residue have been shown to cause epileptic encephalopathy and a recognizable facial gestalt. We report two additional individuals with intellectual disability, dysmorphic features, hypertrichosis, macrocephaly and the same de novo KCNT2 missense variants af... | no |
converted_867 | Are psammoma bodies characteristic to meningiomas? | Psammoma bodies (PBs) are concentric lamellated calcified structures, observed most commonly in papillary thyroid carcinoma (PTC), meningioma, and papillary serous cystadenocarcinoma of ovary but have rarely been reported in other neoplasms and nonneoplastic lesions., Studies on serous cystadenocarcinoma of ovary and m... | yes |
converted_856 | Is Dicer part of the RISC loading complex? | Dicer is a component of the protein machinery (the RNA Induced Silencing Complex [RISC]) which is involved in catalyzing the formation of mature microRNAs from their precursors in the process of microRNA biogenesis., RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor co... | yes |
converted_1287 | Can the apoptosis regulator BAX trigger the release of cytochrome c? | 6-Shogaol reduced the mitochondrial membrane potential (MMP) and released cytochrome c from mitochondria to cytosol via Bax activation. , Moreover, overexpression of ERβ prevented Bax activation, cytochrome c release, caspase-3 activation, and PARP cleavage during apoptosis., In this study, we demonstrated that EV71 in... | yes |
converted_1532 | Is selumetinib effective in thyroid cancer? | A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours., BACKGROUND: We completed a phase I clinical trial to test the safety and toxicity of combined treatment with cixutumumab (anti-IGF-1R antibody) and selu... | yes |
converted_882 | Is nivolumab used for treatment of Non–Small-Cell Lung Cancer? | BACKGROUND: Patients with advanced squamous-cell non-small-cell lung cancer (NSCLC) who have disease progression during or after first-line chemotherapy have limited treatment options. This randomized, open-label, international, phase 3 study evaluated the efficacy and safety of nivolumab, a fully human IgG4 programmed... | yes |
converted_1520 | Is there any data to suggest that TRH (thyrotropin releasing hormone) administration can improve symptom severity of amyotrophic lateral sclerosis patients? | These central nervous system (CNS)-mediated effects provide the rationale for use of TRH and its analogs in the treatment of brain and spinal injury, and CNS disorders like schizophrenia, Alzheimer's disease, epilepsy, amyotrophic lateral sclerosis, Parkinson's disease, depression, shock and ischemia., The Effect of TR... | yes |
converted_785 | Is flibanserin effetive for Hypoactive Sexual Desire Disorder? | Mechanism of action of flibanserin, a multifunctional serotonin agonist and antagonist (MSAA), in hypoactive sexual desire disorder., Flibanserin is a novel multifunctional serotonin agonist and antagonist (MSAA) that improves sexual functioning in premenopausal women who suffer from reduced sexual interest and desire.... | yes |
converted_1331 | Is there a difference in the rate between gene fusion and gene fission? | we illustrate arrangement diversity within closely related organisms, estimate arrangement turnover frequency and establish, for the first time, branch-specific rate estimates for fusion, fission, domain addition and terminal loss., Rate and polarity of gene fusion and fission in Oryza sativa and Arabidopsis thaliana, ... | yes |
converted_4601 | Is Epistaxis associated with dental implant placement? | The overall survival rate of the implants into the sinus cavity was 95.6%, without statistical differences according to the level of penetration. The clinical and radiological complications were 3.4% and 14.8% respectively. The most frequent clinical complication was the epistaxis, , implant placement and protrusion o... | yes |
converted_3073 | Is the NLM medical text indexer (MTI) still useful and relevant? | 12 years on - Is the NLM medical text indexer still useful and relevant?, Facing a growing workload and dwindling resources, the US National Library of Medicine (NLM) created the Indexing Initiative project in 1996. This cross-library team's mission is to explore indexing methodologies for ensuring quality and currency... | yes |
converted_1751 | Is Thalidomide currently a marketed drug? | In this retrospective study, pharmacy claims were analyzed for those patients with a diagnosis of MM who received thalidomide,, The Japanese POEMS syndrome with Thalidomide (J-POST) Trial is a phase II/III multicentre, double-blinded, randomised, controlled trial that aims to evaluate the efficacy and safety of a 24-we... | yes |
converted_4565 | Is Sotrovimab effective for COVID-19? | It seems that monoclonal antibodies (e.g., low dosage bamlanivimab, baricitinib, imatinib, and sotrovimab) are a better choice for treating severe or non-severe COVID-19 patients. , The Food and Drug Administration has granted emergency use authorization to sotrovimab for the treatment of mild to moderate COVID-19 in p... | yes |
converted_4112 | Is there a role for TFII-I in megakaryopoiesis? | TFII-I/Gtf2i and Erythro-Megakaryopoiesis., TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer. Williams-Beuren Syndrome (WBS) is caused by a large hemizyg... | yes |
converted_4535 | Is there a way to distinguish COVID-19 clinically from other respiratory illnesses, particularly influenza? | Findings indicate that clinical symptoms alone would be insufficient to distinguish between coronavirus disease 2019 and other respiratory infections (eg, influenza) and/or to evaluate the effects of preventive interventions (eg, vaccinations)., Our reasoning highlights how challenging a balanced approach to a patient ... | no |
converted_4708 | Can whole genome sequencing be used for diagnosis of mitochondrial disease? | Whole genome sequencing is a useful diagnostic test in patients with suspected mitochondrial disorders, yielding a diagnosis in a further 31% after exclusion of common causes. Most diagnoses were non-mitochondrial disorders and included developmental disorders with intellectual disability, epileptic encephalopathies, o... | yes |
converted_4566 | Is Otolin-1 a matrix protein? | otoconia matrix protein, otolin-1, Otolin-1 is a collagen-like protein expressed in the inner ear of vertebrates. , Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1, binds to otolin-1 and forming matrix protein architectures[... | yes |
converted_676 | Has proteomics been used in the study of Pick's disease? | In Pick's disease, increased AGE, CML, CEL, HNE and MDAL bands of about 50 kDa were observed in the frontal cortex (but not in the occipital cortex) in association with increased density of glial acidic protein bands., Thus, brain and cerebrospinal fluid (CSF) samples from patients with Alzheimer's disease, Down syndro... | yes |
converted_2496 | Does prolactinoma increase osteoporosis risk? | Prolactinoma: A Massive Effect on Bone Mineral Density in a Young Patient., Osteoporosis has been noted to be an issue in postmenopausal women with prolactinomas. This case shows a similar impact on bone health in a young male resulting in low bone mineral density for age based on Z-score. This case report highlights t... | yes |
converted_3994 | Is there an association of alterations in ADCY7 and ulcerative colitis? | To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low coverage and compared them to 3,652 previously sequenced population controls across 73.5 million variants. We then imputed from these sequences i... | yes |
converted_1272 | Is curcumin a phytochemical? | we analyzed turmeric from different agroclimatic regions for influence of various factors on its growth and yield of important phytochemicals, The phytochemical, curcumin, has been reported to play many beneficial roles., Curcumin (CUR), the major component in Curcuma longa, has been shown as a potent chemopreventive p... | yes |
converted_3829 | Is there any role of genotoxic pks + E. coli in cancer? | Mutational signature in colorectal cancer caused by genotoxic pks+, Various species of the intestinal microbiota have been associated with the development of colorectal cancer1,2, but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the p... | yes |
converted_540 | Is Calcium homeostasis important in cardiac physiology and pathophysiology? | Maintenance of cellular calcium homeostasis is critical to regulating mitochondrial ATP production and cardiac contraction. , the Ca(2+) signal regulates the most important activities of the cell, from the expression of genes, to heart and muscle contraction and other motility processes, to diverse metabolic pathways i... | yes |
converted_4300 | Is istiratumab effective for pancreatic cancer? | CONCLUSIONS: Istiratumab failed to improve the efficacy of SOC chemotherapy in this patient setting. [SEP]Definitions: pancreatic cancer defined as following: A primary or metastatic malignant tumor involving the pancreas. Representative examples include carcinoma and lymphoma.. | no |
converted_2409 | Are mouse chromosomes acrocentric? | Based on combined fluorescence in situ hybridization and linkage mapping, the gene order on CFA9 is similar to that of the homologous genes on HSA17q and mouse chromosome 11 (MMU11), but in the dog the gene order is inverted with respect to the centromere. , In murine models of human carcinogenesis, however, karyotype... | yes |
converted_4024 | Is the apilimod inhibitor effective against SARS-CoV-2? | To identify therapeutics that can be repurposed as SARS-CoV-2 antivirals, we profiled a library of known drugs encompassing approximately 12,000 clinical-stage or FDA-approved small molecules. Here, we report the identification of 30 known drugs that inhibit viral replication. Of these, six were characterized for cellu... | yes |
converted_437 | Is there a role for the cylindromatosis tumor suppressor (CYLD) in lung cancer? | Over-expressing CYLD augments antitumor activity of TRAIL by inhibiting the NF-κB survival signaling in lung cancer cells, increased expression of CYLD directly blocks TRAIL-induced NF-κB activation, and consequently increases TRAIL-induced apoptosis in lung cancer cells. CYLD may act as a therapeutic target of lung ca... | yes |
converted_1416 | Is c-myc subject to regulation by the circadian clock? | The current study encompasses the investigation of simultaneous expression of four circadian clock genes (Bmal1, Clock, Per1 and Per2) and three clock-controlled cell cycle genes (Myc, Cyclin D1 and Wee1), Our results suggest that aberrant expression of circadian clock genes can lead to aberrant expression of their dow... | yes |
converted_2871 | Are de novo mutations in regulatory elements responsible for neurodevelopmental disorders? | The role of de novo mutations in regulatory elements affecting genes associated with developmental disorders, or other genes, has been essentially unexplored. We identified de novo mutations in three classes of putative regulatory elements in almost 8,000 patients with developmental disorders. Here we show that de novo... | yes |
converted_4434 | Is Satb1 a transcription factor? | Special AT-rich sequence binding protein-1 (SATB1) is localized to the nucleus and remodels chromatin structure in T cells, chromatin organizers SATB2 and SATB1 , transcription factor complexes. These MYB complexes assemble aberrantly with LYL1, E2A, C/EBP family members, LMO2, and SATB1. , Staining for the transcripti... | yes |
converted_2271 | Is davunetide being considered for the treatment of progressive supranuclear palsy? | Critical appraisal of the role of davunetide in the treatment of progressive supranuclear palsy., Davunetide's efficacy and tolerability are being tested in a placebo-controlled study in PSP patients, making it the most advanced drug candidate in this indication. This review examines the disease characteristics of PSP,... | yes |
converted_523 | Is stop codon bypass possible? | In 1999, proof-of-concept for treating these disorders was obtained in a mouse model of muscular dystrophy, when administration of aminoglycosides restored protein translation by inducing the ribosome to bypass a PTC., Aminoglycosides can bypass nonsense mutations and are the prototypic agents for translational bypass ... | yes |
converted_4392 | Are TAMs good anticancer therapeutic targets? | Integrating therapeutic strategies to target TAMs to complement conventional therapies has yielded promising results in preclinical trials and warrants further investigation to determine its translational benefit in human cancer patients.[SEP]Definitions: human defined as following: Members of the species Homo sapiens.... | yes |
converted_3444 | Does ProSavin use an adenoviral vector? | Long-Term Follow-Up of a Phase I/II Study of ProSavin, a Lentiviral Vector Gene Therapy for Parkinson's Disease., ProSavin, a lentiviral vector based gene therapy that delivers local and continuous dopamine, was previously shown to be well tolerated in a Phase I/II first-in-human study, with significant improvements in... | no |
converted_1580 | Do Conserved noncoding elements act as enhancers? | The aCNEs are rich in tissue-specific enhancers, Transgenic zebrafish assay of some human CNE enhancers that have been lost in teleosts, Conserved noncoding elements (CNEs) in vertebrate genomes often act as developmental enhancers,, In all four cases where the zebra fish and human CNE display a similar expression patt... | yes |
converted_1656 | Is the microRNA 132 (miR-132) involved in brain pathologies? | miR-132 dysregulation and subsequent abnormal expression of miR-132 target genes contribute to the neurodevelopmental and neuromorphological pathologies present in schizophrenia., micro-RNAs encoding miR-9, miR-124a, miR-125b, miR-128, miR-132 and miR-219 are abundantly represented in fetal hippocampus, are differentia... | yes |
converted_436 | Is progesterone effective for treatment of patients with traumatic brain injury based on clinical trial data? | BACKGROUND: Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. , The proportion of patients with a favorable outcome on the Glasgow Outcome Scale (good recovery or moderate disability) wa... | no |
converted_1408 | Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) cause sudden cardiac death? | Here we refine our approach, and apply it to novel variants found in 2266 patients across two large cohorts with inherited sudden death syndromes, namely catecholaminergic polymorphic ventricular tachycardia (CPVT) or Brugada syndrome (BrS)., Calsequestrin-associated catecholaminergic polymorphic ventricular tachycardi... | yes |
converted_2096 | Is Cryptococcus neoformans a frequent cause of isolated skin infections in immunocompromised individuals | Cryptococcus is an opportunistic yeast with a worldwide distribution that primarily causes significant infections in immunocompromised individuals, generally by affecting the respiratory tract. But primary cutaneous cryptococcosis (PCC) without systemic infection is rare. , Cryptococcus is a ubiquitous fungus and is k... | no |
converted_3580 | Can discharge destinations be accurately predicted using the Risk Assessment and Prediction Tool (RAPT)? | CONCLUSION: Our analysis identified age, lower lumbar/lumbosacral surgery, and RAPT walk score as independent predictors of discharge to SNF, and demonstrated superior predictive power compared with the total RAPT Score when combined in a novel grading scale. , PURPOSE: The aim of this study was to evaluate the value o... | yes |
converted_742 | Can mutations in Calmodulin cause ventricular fibrillation? | We characterized a family presenting with a history of ventricular fibrillation (VF) and sudden death without ECG or echocardiographic abnormalities at rest. Two siblings died suddenly at the ages of 9 and 10 years, and another two were resuscitated from out-of-hospital cardiac arrest with documented VF at age 10 and 1... | yes |
converted_4266 | Is cytokeratin a tumor marker? | cytokeratin fragment antigen 21-1 (CYFRA21-1) in patients with laryngeal squamous cell carcinoma (LSCC) and its correlation with tumorigenesis and progression, cytokeratin fragment 19 (AUC=0.6882, p<0.0001) proved best in detecting relapse., The immunohistochemistry staining for cancer antigen 19-9, carcinoembryonic a... | yes |
converted_4698 | Can autophagy related lncRNAs be used for colorectal cancer prognosis? | A Novel Prognostic Prediction Model for Colorectal Cancer Based on Nine Autophagy-Related Long Noncoding RNAs, A prognostic prediction model of CRC was built based on nine ARlncRNAs (NKILA, LINC00174, AC008760.1, LINC02041, PCAT6, AC156455.1, LINC01503, LINC00957, and CD27-AS1). The 5-year overall survival rate was sig... | yes |
converted_705 | Is Bladder training an effective method to treat urge incontinence ? | Mindfulness-based stress reduction appears to be a treatment worthy of further study, as in the short term, it is as effective as historical studies of drug treatment and bladder training in reducing urge incontinence and incontinence-related quality of life., All patients, irrespective of the results of cystometry wer... | yes |
converted_288 | Can zinc finger nucleases be used to combat disease? | Genetic engineering has emerged as a powerful mechanism for understanding biological systems and a potential approach for redressing congenital disease., This is of particular importance, given the momentum currently behind ZFNs in moving into phase I clinical trials. This study provides a historical account of the ori... | yes |
converted_2790 | Is the PINES framework being used for the prediction of coding variants? | PINES: phenotype-informed tissue weighting improves prediction of pathogenic noncoding variants., Here, we introduce the computational framework PINES (Phenotype-Informed Noncoding Element Scoring), which predicts the functional impact of noncoding variants by integrating epigenetic annotations in a phenotype-dependent... | no |
converted_994 | Is DNA methylation an epigenetic modification of chromatin related to gene expression? | DNA methylation is a chemical modification of DNA involved in the regulation of gene expression by controlling the access to the DNA sequence. , Epigenetic marks such as DNA methylation play important biological roles in gene expression regulation and cellular differentiation during development., DNA methylation patter... | yes |
converted_2327 | Is ACI-35 a passive vaccine? | Two active vaccines targeting either nonphosphorylated (AAD-vac1) and phosphorylated tau (ACI-35) have entered Phase I testing.[SEP] | no |
converted_1691 | Is STAT3 transcription factor regulated by mTORC1? | Mechanistically, mTORC1 mediated IL-6-induced Stat3 activation in intestinal epithelial cells to stimulate the expression of downstream targets essential for cell proliferation and tissue regeneration. Therefore, mTORC1 signaling critically protects against inflammatory bowel disease through modulation of inflammation-... | yes |
converted_2658 | Does International Citicoline Trial on acUte Stroke trial supports efficacy of citicoline for stroke treatment? | The meta-analysis showed that no significant differences were found in the long-term mortality (OR=0.91, 95% CI 0.07 to 1.09, P=0.30), the rate of dependency (OR=1.02, 95% CI 0.87 to 1.24, P=0.85), and the effective rate (OR=0.98, 95% CI 0.84 to 1.14, P=0.82) between citicoline group and control group. , In conclusion... | no |
converted_2275 | Is Drk essential for anesthesia-resistant memory (ARM) in Drosophila? | Anesthesia-resistant memory (ARM) was described decades ago, but the mechanisms that underlie this protein synthesis-independent form of consolidated memory inDrosophilaremain poorly understood. Whether the several signaling molecules, receptors, and synaptic proteins currently implicated in ARM operate in one or more ... | yes |
converted_3736 | Is αCGRP a member of the CGRP family? | αCGRP, another amyloidogenic member of the CGRP family., Therefore, in this work, we investigated the amyloidogenic profile of αCGRP, a 37-residue-long peptide hormone, utilizing both biophysical experimental techniques and Molecular Dynamics simulations. These efforts unravel a novel amyloidogenic member of the CGRP f... | yes |
converted_528 | Is there any software for automated analysis of immuno-histochemistry images? | The LIM homeobox gene Lhx2 is expressed in cortical progenitors during development and also in the superficial layers of the neocortex in maturity. However, analysis of Lhx2 function at later stages of cortical development has been hampered by severe phenotypes associated with early loss of function. , The vein graft s... | yes |
converted_1883 | Is there any tool that facilitates the functional analysis of cis-regulatory regions in zebrafish? | Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish., he cis-regulatory sequences control when, where, and how much genes are transcribed and can activate (enhancers) or repress (silencers) gene expression. Here, we describe... | yes |
converted_3048 | Can pazopanib be used for treatment von Hippel-Lindau disease? | Variable response of CNS hemangioblastomas to Pazopanib in a single patient with von Hippel-Lindau disease: Case report., Treatment of RCCs with tyrosine kinase inhibitors (TKIs) such as Pazopanib is now first line therapy, but their effect on VHL-associated CNS HBs remains unknown. We report the use of Pazopanib in a ... | yes |
converted_3620 | Are tumour specific antigens originating from known protein coding genes? | It is well established that MHC class I molecules present peptides from endogenous proteins, such as virus or tumour antigens, to CD8+ T lymphocytes. , So far, human tumour specific antigens that can be presented by HLA molecules have not been identified on the molecular level., These CTLs recognize short peptides deri... | yes |
converted_3284 | Do de novo truncating mutations in WASF1 cause cancer? | De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures., Here, using exome sequencing and whole-genome sequencing, we identified three de novo truncating mutations in WAS protein family member 1 (WASF1) in five unrelated individuals with moderate to profound intellectual disability with autis... | no |
converted_67 | Is TENS machine effective in pain? | Transcutaneous electrical nerve stimulation is widely used in pain management but its effectiveness depends on the stimulation being targeted appropriately, hypoalgesic effects of transcutaneous electrical nerve stimulation upon experimentally induced ischaemic pain., The results of this study have provided evidence of... | yes |
converted_4439 | Are circular RNAs implicated in diseases of the eye? | n this review, we summarized the function of circRNAs and indicated their roles in the pathogenesis of DR, which may provide new therapeutic targets for clinical treatment., This study aimed to determine whether circular RNAs (circRNAs) in whole blood could be served as novel non-invasive biomarkers for proliferative d... | yes |
converted_1057 | Are there clinical trials on stem cells in multiple sclerosis | Cells are generally given intravenously. Multiple sclerosis, rheumatoid arthritis and lupus have been successfully treated in human clinical trials, Human multipotent mesenchymal stem cell (MSC) therapies are currently being tested in clinical trials for Crohn's disease, multiple sclerosis, graft-versus-host disease, t... | yes |
converted_3387 | Has ZP-PTH been tested in a phase II clinical trial? | This system was successfully tested in a Phase 2 clinical trial for the treatment of post-menopausal women with osteoporosis.[SEP] | yes |
converted_1941 | Is NSD-1015 an inhibitor of Aromatic L-Amino Acid Decarboxylase? | When pretreated with a central AADC inhibitor (NSD-1015), further application of l-dopa failed to increase the motoneuron activity although the expression of DA in the AADC cells was not completely inhibited. , Inhibition of Ddc by AADC inhibitor NSD-1015 or anti-sense morpholino oligonucleotides (MO) reduced brain vol... | yes |
converted_3813 | Is aggrephagy a variant of autophagy? | The selective branch of autophagy that deals with identification, capture and degradation of protein aggregates is called aggrephagy., Mechanistic insights into aggrephagy, a selective basal autophagy process to clear misfolded protein aggregates, , , it is largely unknown how misfolded polypeptides form aggresomes and... | yes |
converted_76 | Is CD56 useful in Ewing sarcoma prognosis? | Excellent prognosis in a subset of patients with Ewing sarcoma identified at diagnosis by CD56 using flow cytometry, There was a highly significant correlation between CD56 expression and progression-free survival (PFS; 69% in low/negative expression versus 30% in high expression groups, P = 0.024), In patients with lo... | yes |
converted_1071 | Are there any specific antidotes for dabigatran? | Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of intracerebral hemorrhage (ICH). However, two facts make this situation complicated: First, the risk of hematoma expansion is unknown for NOACs. Second, there is no specific antidote for neither of the NOACs. ,... | no |
converted_1302 | Does thyroid hormone signaling affect microRNAs expression in the heart? | e show that the heart regulates systemic energy homeostasis via MED13, a subunit of the Mediator complex, which controls transcription by thyroid hormone and other nuclear hormone receptors. MED13, in turn, is negatively regulated by a heart-specific microRNA, miR-208a., On the other hand, T₃ treatment increased miR-35... | yes |
converted_4409 | Does addition of valproic acid improve survival of patients with diffuse intrinsic pontine glioma? | Median event-free survival (EFS) and overall survival (OS) for DIPG were 7.8 (95% CI 5.6-8.2) and 10.3 (7.4-13.4) months, and estimated one-year EFS was 12% (2%-31%). Median EFS and OS for HGG were 9.1 (6.4-11) and 12.1 (10-22.1) months, and estimated one-year EFS was 24% (7%-45%). , CONCLUSION: Addition of VPA and bev... | no |
converted_3183 | Are protamines ubiquitously expressed? | Protamines are nuclear proteins which are specifically expressed in haploid male germ cells.[SEP]Definitions: Protamines defined as following: A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino ... | no |
converted_4273 | Is tofacitinib a JAK inhibitor? | The Janus Kinase inhibitor tofacitinib impacts human dendritic cell differentiation and favours M1 macrophage development., Tofacitinib, a small JAK inhibitor, is approved for the treatment of RA and has demonstrated good efficacy in psoriasis phase III clinical trials. [SEP]Definitions: JAK defined as following: A fam... | yes |
converted_4138 | Is methotrexate used for the treatment of Rheumatoid Arthritis (RA)? | The use of methotrexate in rheumatoid arthritis., Historical perspective on the use of methotrexate for the treatment of rheumatoid arthritis., Aminopterin, a folic acid analogue was first reported in 1948 to produce temporary remission of acute leukemia of children, was also reported in 1951 to produce an important an... | yes |
converted_3216 | Is collagen matrix of human articular cartilage changing with disease? | The collagen matrix of human articular cartilage is an essentially permanent structure that has no significant turnover in adults, even with the occurrence of disease., the chondrocytes in ageing articular cartilage have limited capacity to turnover the interterritorial matrix., Type II collagen is a major component of... | no |
converted_3937 | Are mucins glycosylated proteins? | Many members of the mucin family are evolutionarily conserved and are often aberrantly expressed and glycosylated in various benign and malignant pathologies leading to tumor invasion, metastasis, and immune evasion., Mucin is a glycoprotein that is the primary component of the mucus overlaying the epithelial tissues. ... | yes |
converted_3610 | Is g-H2AX a marker for double strand breaks? | The specific phosphorylation of histone H2AX on serine residue 139, described as γ-H2AX, is an excellent indicator or marker of DNA double-strand breaks (DSBs). , expression of the DNA double-strand break marker gamma-H2AX (γH2AX) , pH2AX, a marker of the DNA double-strand break (DSB)[SEP]Definitions: serine defined as... | yes |
converted_1226 | Are there interactomes available for POU5F1 and SOX2? | The interactomes of POU5F1 and SOX2 enhancers in human embryonic stem cells., We assayed long-range chromosomal interactions on putative enhancers of POU5F1 and SOX2 genes in human embryonic stem cells (hESCs) using 4C-Seq technique. We discovered that their frequent interacting regions mainly overlap with early DNA re... | yes |
converted_1574 | Does the concentration of protein HIF-1α increase after the administration of the cytoprotective prodrug"amifostine" (ethyol) ? | We demonstrated that the treatment of several human cancer cell lines with therapeutical doses of WR-1065 led to a strong induction of different VEGF-A mRNA isoforms independently of HIF-1alpha, e investigated the involvement of hypoxia-regulated proteins (Hypoxia inducible factors HIF1alpha, HIF2alpha and carbonic anh... | yes |
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