id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 55 47.9k | label stringclasses 2
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converted_1658 | Does cucumber lower blood sugar in diabetics? | The ethanolic extract of Cucumis sativus Linn, Cucumis melo utilissimum Roxb, Cucumis melo Linn, Benincasa hispida Thunb Cogn and Tricosanthes anguina Nees, when administered in 250 mg/kg dose, orally to rats failed to lower blood sugar or to depress the peak value, after glucose load., Ethanolic extract of Tricosanthe... | yes |
converted_3930 | Has the olive tree pollen proteome been studied? | Olive pollen is a major allergenic source worldwide due to its extensive cultivation. We have combined available genomics data with a comprehensive proteomics approach to get the annotated olive tree (Olea europaea L.) pollen proteome and define its complex allergenome. [SEP] | yes |
converted_2934 | Have machine learning methods been used to predict the severity of major depressive disorder(MDD)? | Here, we conduct a meta-review to identify predictors of response to antidepressant therapy in order to select robust input features for machine learning models of treatment response. , machine learning framework involving EEG-based functional connectivity to diagnose major depressive disorder (MDD)., Identification of... | yes |
converted_4543 | Is CircRNA produced by back splicing of exon, intron or both, forming exon or intron circRNA? | CircRNAs are a subclass of lncRNAs that have been found to be abundantly present in a wide range of species, including humans. CircRNAs are generally produced by a noncanonical splicing event called backsplicing that is dependent on the canonical splicing machinery, giving rise to circRNAs classified into three main ca... | yes |
converted_967 | Are CTCF and BORIS involved in genome regulation and cancer? | CTCF is ubiquitously expressed and plays diverse roles in gene regulation, imprinting, insulation, intra/interchromosomal interactions, nuclear compartmentalisation, and alternative splicing. CTCF has a single paralogue, the testes-specific CTCF-like gene (CTCFL)/BORIS. CTCF and BORIS can be deregulated in cancer. The ... | yes |
converted_848 | Is there a pharmacogenetic test for trastuzumab? | The clinical need for novel approaches to improve drug therapy derives from the high rate of adverse reactions to drugs and their lack of efficacy in many individuals that may be predicted by pharmacogenetic testing., the assessment of the human epidermal growth factor receptor (HER-2) expression for trastuzumab therap... | yes |
converted_2959 | Is Adar3 involved in learning and memory? | Adar3 Is Involved in Learning and Memory in Mice., The newest member of the A-I editing family of ADAR proteins, the vertebrate-specific ADAR3, is highly expressed in the brain, but its functional significance is unknown. In vitro studies have suggested that ADAR3 acts as a negative regulator of A-I RNA editing but th... | yes |
converted_3792 | Is tocilizumab a csDMARD? | The task force agreed on 5 overarching principles and 12 recommendations concerning use of conventional synthetic (cs) DMARDs (methotrexate (MTX), leflunomide, sulfasalazine); glucocorticoids (GCs); biological (b) DMARDs (tumour necrosis factor inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, inflixim... | no |
converted_1360 | Is triadin involved in cardiac function? | Junctin (JCN), a 26-kd sarcoplasmic reticulum (SR) transmembrane protein, forms a quaternary protein complex with the ryanodine receptor, calsequestrin, and triadin in the SR lumen of cardiac muscle. Within this complex, calsequestrin, triadin, and JCN appear to be critical for normal regulation of ryanodine receptor-m... | yes |
converted_811 | Is myasthenia gravis associated with osteoporosis? | We performed PVP in 4 patients with generalized MG associated with recent steroid-induced symptomatic VFs. , In this case report, we used tacrolimus to successfully treat a 13-year-old boy with ocular MG who had suffered from severe steroid complications, including a failure of thrive and osteoporosis., INTRODUCTION: ... | yes |
converted_364 | Is alemtuzumab effective for remission induction in patients diagnosed with T-cell prolymphocytic leukemia? | Sequential chemoimmunotherapy of fludarabine, mitoxantrone, and cyclophosphamide induction followed by alemtuzumab consolidation is effective in T-cell prolymphocytic leukemia, A central need in this historically refractory tumor is the controlled evaluation of multiagent chemotherapy and its combination with the curre... | yes |
converted_1987 | Is H4K20 methylation associated with DNA replication? | It seems likely that continued study of the methylation of H4K20 will yield extremely valuable insights concerning the regulation of histone modifications before and during cell division and the impact of these modifications on subsequent gene expression., Aberrant rereplication correlates with decreased levels of H4K2... | yes |
converted_3777 | Does protein ALEX1 contain armadillo repeats? | ALEX1 (Arm protein lost in epithelial cancers, on chromosome X), contains two armadillo repeats domains, is expressed different in normal and carcinomas tissues., Arm protein lost in epithelial cancers, on chromosome X 1 (ALEX1) is a novel member of the Armadillo family which has two Armadillo repeats as opposed to mor... | yes |
converted_1489 | Is there any role for long noncoding RNAs in adipogenesis? | Long noncoding RNAs regulate adipogenesis., Here we profiled the transcriptome of primary brown and white adipocytes, preadipocytes, and cultured adipocytes and identified 175 lncRNAs that are specifically regulated during adipogenesis. Many lncRNAs are adipose-enriched, strongly induced during adipogenesis, and bound ... | yes |
converted_3466 | Is Hemochromatosis type 4 is caused by a mutation in a recessive gene? | severely affect iron homeostasis causing type 4 hereditary hemochromatosis, an autosomal dominant iron overload condition with variable phenotypic manifestations, Hemochromatosis type 4, also known as ferroportin disease, is an autosomal dominant genetic disorder caused by pathogenic mutations in the SLC40A1 gene, whi... | no |
converted_1942 | Is pseudouridine a RNA modification? | Pseudouridine (Ψ) is the most abundant of>150 nucleoside modifications in RNA. , The number and position of the pseudouridines of Haloarcula marismortui and Deinococcus radiodurans large subunit RNA have been determined by a combination of total nucleoside analysis by HPLC-mass spectrometry and pseudouridine sequencing... | yes |
converted_3440 | Does teplizumab hold promise for diabetes prevention? | Anti-CD3 teplizumab and anti-CD3 otelixizumab have been shown to provide C-peptide preservation. , Underway are secondary prevention studies with teplizumab and with abatacept., INTERPRETATION: Findings of exploratory analyses suggest that future studies of immunotherapeutic intervention with teplizumab might have incr... | yes |
converted_3357 | Is SARS virus interacting with ACE2 encoded protein? | The trimeric SARS coronavirus (SARS-CoV) surface spike (S) glycoprotein consisting of three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 (ACE2) and mediates fusion of the viral and cellular membranes through a pre- to postfusion conformation transition, The viral spike glycoprotein (S)... | yes |
converted_3706 | Do genes with monoallelic expression contribute proportionally to genetic diversity in humans? | Genes with monoallelic expression contribute disproportionately to genetic diversity in humans., An unexpectedly large number of human autosomal genes are subject to monoallelic expression (MAE). Our analysis of 4,227 such genes uncovers surprisingly high genetic variation across human populations. This increased diver... | no |
converted_1223 | Is there any association of the chromosomal region harboring the gene ITIH3 with schizophrenia? | The most widely shared subset of genes-common to five of six disorders-included ANK3, AS3MT, CACNA1C, CACNB2, CNNM2, CSMD1, DPCR1, ITIH3, NT5C2, PPP1R11, SYNE1, TCF4, TENM4, TRIM26, and ZNRD1. , Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associati... | yes |
converted_4461 | Is tivantinib effective for MET-high hepatocellular carcinoma? | BACKGROUND: Tivantinib (ARQ 197), a selective, oral MET inhibitor, improved overall survival and progression-free survival compared with placebo in a randomised phase 2 study in patients with high MET expression (MET-high) hepatocellular carcinoma previously treated with sorafenib., INTERPRETATION: Tivantinib did not i... | no |
converted_480 | Are epigenetic modifications implicated in cardiovascular development and disease? | Gene expression regulation through the interplay of DNA methylation and histone modifications is well-established, although the knowledge about the function of epigenetic signatures in cardiovascular disease is still largely unexplored., The study of epigenetic markers is, therefore, a very promising frontier of scienc... | yes |
converted_3712 | Are stem cell transplants used to treat acute kidney injury? | Animal studies have shown that mesenchymal stromal cell (MSC) infusions improve acute kidney injury (AKI) outcomes when administered early after ischemic/reperfusion injury or within 24 hours after cisplatin administration., Early Diagnostic Markers for Detection of Acute Kidney Injury in Allogeneic Hematopoietic Stem ... | yes |
converted_3255 | Can Daptacel be used instead of IPOL? | Our goal was to compare the safety and immunogenicity of a combination vaccine (DTaP(5)-IPV-Hib; Pentacel) with that of its separately administered, US-licensed equivalent vaccines (diphtheria, tetanus, 5-component acellular pertussis vaccine [DTaP(5); Daptacel], inactivated poliovirus vaccine [IPV; IPOL], and Haemophi... | no |
converted_4258 | Can FTO promote pancreatic cancer development? | m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling., Moreover, FTO demethylated the m6A modification of praja ring finger ubiquitin ligase 2 (PJA2), thereby reducing its mRNA decay, suppressing Wnt signaling, and ultimately restraining the proliferation, in... | no |
converted_2357 | Is Kummell’s disease an avascular necrosis of the vertebral body? | Kummell's disease is an avascular necrosis of the vertebral body, secondary to a vertebral compression fracture. This entity is characterised by the gradual development in time of a vertebral body collapse following a trivial spinal trauma, involving a worsening back pain associated with a progressive kyphosis., Kumme... | yes |
converted_2491 | Has ATF4 transcription factor been linked to cancer and neoplastic transformation? | aken together, we discovered a novel axis of BCL10-regulated OSCC progression via STAT1/ATF4/S100P/P65 signaling, which could predict the prognosis of OSCC and will be beneficial for developing therapeutic strategy against advanced OSCC, s a result, the level of phosphorylated Eukaryotic Initiation Factor 2 alpha (eIF2... | yes |
converted_3970 | Does erenumab target the calcitonin gene-related peptide? | Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor (erenumab) and three targeting the calcitonin gene-related peptide (eptinezumab, fremanezumab, and galcanezumab).[SEP]Relations: CALCRL has relations: drug_protein with Erenumab, drug_protein with Erenumab, molfun... | no |
converted_3340 | Is MLL3 part of the ASCOM complex? | MLL3 as part of ASCOM complex, MLL3 as part of activating signal cointegrator-2 -containing complex (ASCOM)[SEP]Definitions: MLL3 defined as following: This gene plays a role in both methylation and transcriptional regulation. | yes |
converted_1733 | Is mitofusin 2 a receptor for parkin? | Recent work demonstrates that a phosphorylated form of the mitochondrial fusion protein Mitofusin 2 serves as a receptor for Parkin translocation to damaged mitochondria., We show that the mitochondrial outer membrane guanosine triphosphatase mitofusin (Mfn) 2 mediates Parkin recruitment to damaged mitochondria. , Mfn2... | yes |
converted_4560 | Is serotonin transported by platelets? | activated platelets, which carry peripheral serotonin,, Platelet serotonin response was measured by serotonin augmented platelet aggregation and platelet serotonin receptor density. , SERT was studied in the 1970s and 1980s using membrane vesicles isolated from blood platelets., platelet-dense granules contain neurotr... | yes |
converted_3938 | Is carpal tunnel syndrome a type of nerve entrapment? | Carpal tunnel syndrome (CTS) is a common entrapment neuropathy, often requiring carpal tunnel release (CTR) surgery., Carpal tunnel syndrome (CTS) is an entrapment neuropathy accounting for up to 90% of nerve compression syndromes, Carpal tunnel syndrome (CTS) is the most frequent entrapment neuropathy in humans. , C... | yes |
converted_4210 | Is the zelda transcription factor a chromatin remodeller? | ncreasing the number of Zelda binding sites accelerates the kinetics of nuclei transcriptional activation regardless of their transcriptional past, Zelda facilitates transcriptional activation by accumulating in microenvironments where it could accelerate the duration of multiple pre-initiation steps., Zelda acts throu... | yes |
converted_245 | Is the Drosophila Translational Control Element (TCE) involved in spermatogenesis? | Gene regulation in Drosophila spermatogenesis: analysis of protein binding at the translational control element TCE., We have previously identified a 12 nucleotide long sequence element, the TCE, that was demonstrated to be necessary for translational control of expression in the male germ line of Drosophila melanogast... | yes |
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