id stringlengths 11 14 | sentence1 stringlengths 23 192 | sentence2 stringlengths 55 19.7k | label stringclasses 2
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converted_4157 | Is metoprolol metabolized by CYP2D6? | Among these beta-blockers atenolol is mainly eliminated by renal excretion, bisoprolol is in part excreted as parent compound via the renal route (50%), the other 50% are hepatically metabolised, whereas metoprolol and carvedilol are metabolised by CYP2D6. [SEP]Metoprolol has relations with CYP2D6, CYP3A4, ADRB2, NN344... | yes |
converted_214 | Are there focused databases from which you can retrieve gene expression data on renal disease? | Proteomics database in chronic kidney disease, Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease[SEP]Chronic kidney disease has relations with glycogen storage disease, disease_phenotype_positive with distal 16p11.2 microdeletion syndrome, and hereditary renal hypouricemia. Chron... | yes |
converted_4485 | Is nerinetide effective for ischaemic stroke? | 337 (61·4%) of 549 patients with nerinetide and 329 (59·2%) of 556 with placebo achieved an mRS score of 0-2 at 90 days (adjusted risk ratio 1·04, 95% CI 0·96-1·14; p=0·35). Secondary outcomes were similar between groups. , INTERPRETATION: Nerinetide did not improve the proportion of patients achieving good clinical ou... | no |
converted_2090 | Can methylenetetrahydrofolate reductase (MTHFR) gene mutations cause homocystinuria? | Methylenetetrahydrofolate reductase (MTHFR) deficiency is a rare autosomal recessive disorder. , Several mutations seen in methylenetetrahydrofolate reductase (MTHFR) give rise to the formation of hyperhomocysteinemia and homocystinuria, a considerable risk factor for cardiovascular and cerebrovascular disorders, by le... | yes |
converted_4677 | Is Ameloblastoma (AB) a benign tumor that never metastasizes? | Ameloblastic carcinoma (AC) is defined as a rare primary epithelial odontogenic malignant neoplasm and the malignant counterpart of benign epithelial odontogenic tumor of ameloblastoma (AB) by the WHO classification, AC develops pulmonary metastasis in about one third of the patients and reveals a poor prognosis, Amelo... | no |
converted_4055 | Is progeria caused by an autosomal recessive gene? | Hutchinson-Gilford progeria syndrome (HGPS) is an autosomal-dominant genetic disease that leads to accelerated aging and often premature death caused by cardiovascular complications. , Hutchinson-Gilford progeria syndrome is an autosomal dominant, rare, fatal pediatric segmental premature aging disease., Progeria is sp... | yes |
converted_4559 | Is there an association between pyostomatitis vegetans and Crohn's disease? | Among the main oral manifestations of IBD are cobblestoning of the oral mucosa, labial swellings with vertical fissures, pyostomatitis vegetans, angular cheilitis, perioral erythema, and glossitis. , Pyostomatitis Vegetans: A Clue for Diagnosis of Silent Crohn's Disease., We present a case of Pyostomatitis vegetans inv... | yes |
converted_1105 | Are thyroid hormone receptor alpha1 mutations implicated in thyroid hormone resistance syndrome? | Mutations in human TRα1 mediate RTH with features of hypothyroidism in particular tissues (e.g. skeleton, gastrointestinal tract), but are not associated with a markedly dysregulated pituitary-thyroid axis., Clinical phenotype of a new type of thyroid hormone resistance caused by a mutation of the TRα1 receptor[SEP]Res... | yes |
converted_3024 | Is deletion at 6q24.2-26 associated with longer survival of patients with high-grade serous ovarian carcinoma (HGSOCs)? | Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients., We found that loss at 6q24.2-26 was significantly associated with the cluster of longer survival independently from other confounding factors (HR = 0.06, 95%CI = 0.01-0.43, Padj = 0.005). The prognostic value of thi... | yes |
converted_733 | Is Sarcolipin a regulatory/inhibitory protein of the Calcium ATPase SERCA? | The activity of SERCA is regulated by two small, homologous membrane proteins called phospholamban (PLB, also known as PLN) and sarcolipin (SLN). Detailed structural information explaining this regulatory mechanism has been lacking, and the structural features defining the pathway through which cytoplasmic Ca(2+) enter... | yes |
converted_4450 | Is SOX10 expressed in melanoma cells? | Our study confirmed that SOX10 is an oncogene and activate Notch signaling pathway, which suggests the potential treatment for melanoma patients by target SOX10/Notch axis., The most commonly used melanocytic markers include S100, Melan-A, HMB45 and SOX10, melanocytic markers melan-A and SOX10 [SEP]S SUMOylation of tra... | yes |
converted_728 | Is the Prostate- Specific Antigen (PSA) test relevant only for prostate cancer? | rostate cancer (PCa) is the most frequently diagnosed malignancy and the second leading cause of cancer death in men, PSA is known to be prostate specific, but not PCa specific, deficiencies of serum PSA as a prostate-cancer-specific diagnostic test are well recognized., medical debate surrounding the use of the prosta... | no |
converted_963 | Is STAT3 involved in EIF2AK2-dependent suppression of autophagy? | STAT3 may act as a competitive inhibitor of EIF2AK2. Indeed, pharmacological or genetic inhibition of STAT3 stimulates EIF2AK2-dependent EIF2S1 phosphorylation and autophagy. Conversely, the overexpression of wild-type STAT3 as well as of STAT3 mutants that cannot be phosphorylated by JAK2 or are excluded from the nucl... | yes |
converted_4697 | Is disruption of immune regulation mechanisms associated with adverse pregnancy outcomes, including preeclampsia (PE)? | Maternal systemic and placental inflammatory responses participate in the pathogenesis of hypertensive disorders of pregnancy including preeclampsia, a pregnancy-specific syndrome, although the role of inflammation remains unclear. , Our results indicate these proteins are new factors that play important roles in the ... | yes |
converted_1623 | Is the Histidine-Rich Calcium Binding protein (HRC) related to arrhythmias and cardiac disease? | A human genetic variant (Ser96Ala) in the sarcoplasmic reticulum (SR) histidine-rich Ca(2+)-binding (HRC) protein has been linked to ventricular arrhythmia and sudden death in dilated cardiomyopathy. , These findings suggest that aberrant SR Ca2+ release and increased susceptibility to delayed afterdepolarizations unde... | yes |
converted_4540 | Do only changes in coding regions of MEF2C cause developmental disorders? | Non-coding region variants upstream of MEF2C cause severe developmental disorder through three distinct loss-of-function mechanisms., Clinical genetic testing of protein-coding regions identifies a likely causative variant in only around half of developmental disorder (DD) cases. The contribution of regulatory variatio... | no |
converted_352 | Are there studies representing the involvement of Notch mutations in neurodegenerative diseases such as Down syndrome, Pick's and Prion's disease, and cadasil syndrome? | he Notch signaling pathway plays a critical role in maintaining the balance between cell proliferation, differentiation and apoptosis, and is a highly conserved signaling pathway that regulates normal development in a context- and dose-dependent manner. Dysregulation of Notch signaling has been suggested to be key even... | yes |
converted_285 | Is ospemifene effective for treatment of dyspareunia? | Ospemifene, a novel selective estrogen receptor modulator, has been developed for the treatment of vulvovaginal atrophy and dyspareunia in postmenopausal women. , For the comparison of short-term ospemifene with placebo, parabasal cells (the standardized mean difference [SMD] = -37.5, 95% confidence interval [CI] = -41... | yes |
converted_4413 | Is there a role for CADM1 in Myelodysplastic syndrome (MDS)? | Together with the frequent simultaneous deletions of KMT2A, ATM and CBL and mutations of ASXL1, SF3B1 and CBL, we show that CADM1 may be important in the physiopathology of the del(11q) MDS, extending its role as tumor-suppressor gene from solid tumors to hematopoietic malignancies., The CADM1 tumor suppressor gene is ... | no |
converted_994 | Is DNA methylation an epigenetic modification of chromatin related to gene expression? | DNA methylation is a chemical modification of DNA involved in the regulation of gene expression by controlling the access to the DNA sequence. , Epigenetic marks such as DNA methylation play important biological roles in gene expression regulation and cellular differentiation during development., DNA methylation patter... | yes |
converted_1477 | Does HuR protein regulate the splicing process? | HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA, Here we describe experiments showing that HuR and TIA1/TIAL1, two kinds of RNA-binding proteins, were involved in the regulation of alternative splicing of SIRT1 pre-mRNA under normal and stress circumstances, HuR increased SIRT1-∆... | yes |
converted_1530 | Does triiodothyronine stimulate red blood cell sodium potassium pump? | reduction in Na+,K+ATPase activity has been demonstrated in red blood cells (RBCs), as well as an inverse correlation between this enzymatic action and free triiodothyronine (FT3) levels., The restoration of normal FT3 values also brings about a normalization of Na+,K+ATPase activity in erythrocytes., at hyperthyroid p... | no |
converted_3555 | Is AZD5153 active in prostate cancer? | AZD5153 Inhibits Prostate Cancer Cell Growth in Vitro and in Vivo., Bromodomain-containing protein 4 (BRD4) overexpression participates in prostate cancer progression by enhancing the transcriptional activity and expression of several key oncogenes. AZD5153 is a novel BRD4 inhibitor.METHODS: Prostate cancer cells were ... | yes |
converted_3387 | Has ZP-PTH been tested in a phase II clinical trial? | This system was successfully tested in a Phase 2 clinical trial for the treatment of post-menopausal women with osteoporosis.[SEP]Relations: stenosis or atrophy of the coronary ostium has relations: disease_disease with abnormal origin or aberrant course of coronary artery, disease_disease with abnormal origin or aberr... | yes |
converted_4535 | Is there a way to distinguish COVID-19 clinically from other respiratory illnesses, particularly influenza? | Findings indicate that clinical symptoms alone would be insufficient to distinguish between coronavirus disease 2019 and other respiratory infections (eg, influenza) and/or to evaluate the effects of preventive interventions (eg, vaccinations)., Our reasoning highlights how challenging a balanced approach to a patient ... | no |
converted_903 | Does Rad9 interact with Aft1 in S.cerevisiae? | Rad9 interacts with Aft1 to facilitate genome surveillance in fragile genomic sites under non-DNA damage-inducing conditions in S. cerevisiae., Here we show that Rad9 checkpoint protein, known to mediate the damage signal from upstream to downstream essential kinases, interacts with Aft1 transcription factor in the bud... | yes |
converted_1701 | Is the protein KCNQ2 associated with idiopathic epilepsy? | Juvenile idiopathic epilepsy (JIE) in Arabian foals resembles benign-familial neonatal convulsion (BFNC) syndrome, a rare idiopathic epilepsy of new-born humans. BFNC syndrome exhibits genetic heterogeneity, as has been hypothesised to occur in Arabian foals, and is known to be caused by mutations in the voltage-gated ... | yes |
converted_1953 | Is ABCE1 involved in ribosomal recycling? | Ribosome recycling orchestrated by the ATP binding cassette (ABC) protein ABCE1 can be considered as the final-or the first-step within the cyclic process of protein synthesis, connecting translation termination and mRNA surveillance with re-initiation., Recent studies have identified ABCE1 as a ribosome-recycling fac... | yes |
converted_2009 | Can Pentraxin 3 predict outcomes of sepsis? | As compared with low serum PTX3and sTWEAK cases, cirrhotic patients with high serum PTX3/sTWEAK levels a have higher probability of new severe infections, severe sepsis, septic shock, type 1 hepatorenal syndrome, in-hospital, and 3-month follow-up mortalities. , Neonates with high nPTX3 concentrations also have lowered... | yes |
converted_3094 | Can cardiospheres be produced from skin fibroblasts? | Therefore, there is an emerging interest in generating cardiosphere-like stem cells from somatic cells via somatic reprogramming. , Here we provide the detailed protocol for generating induced cardiospheres (iCS) for cardiac regeneration by somatic reprogramming of mouse fibroblasts using a panel of pluripotent transcr... | yes |
converted_2226 | Is there any involvement of L1 retrotransposition in the Rett syndrome? | Using neuronal progenitor cells derived from human induced pluripotent stem cells and human tissues, we revealed that patients with Rett syndrome (RTT), carrying MeCP2 mutations, have increased susceptibility for L1 retrotransposition. Our data demonstrate that L1 retrotransposition can be controlled in a tissue-specif... | yes |
converted_1950 | Do T-Cells regulate neuropathic pain? | here is evidence for a considerable impact of the immune system also in neuropathic pain. However, the role of the adaptive immune system is still unclear., Our investigation revealed a clear shift of T-cell subsets towards anti-inflammation in patients with neuropathic pain. , GITRL expressed on macrophages drives c... | yes |
converted_275 | Is shotgun lipidomics the direct infusion of a lipid sample into a mass spectrometer? | In direct infusion/injection (or shotgun) lipidomics, An efficient shotgun lipidomics strategy was established and optimized for fast phospholipid profiling of viscera from three fish species: Lateolabrax japonicas, Ctenopharyngodon idellus, and Carassius auratus. This strategy relies on direct infusion of total lipid ... | yes |
converted_745 | Is rivaroxaban metabolized in kidneys? | The novel oral anticoagulants (i.e., dabigatran, apixaban, rivaroxaban) all undergo renal metabolism to varying degrees, and hence dosing, efficacy, and safety require special consideration in CKD patients., The new oral anticoagulants have relatively little data in patients with severe renal impairment, and all have a... | yes |
converted_1853 | Could hypophosphatemic rickets cause craniosynostosis? | This study examines a series of patients with hypophosphatemic rickets and craniosynostosis to characterize the clinical course and associated craniofacial anomalies. , Hypophosphatemic rickets and craniosynostosis: a multicenter case series., A 20-year retrospective review identified patients with hypophosphatemic ric... | yes |
converted_4419 | Is Sotatercept effective for Pulmonary Arterial Hypertension? | Sotatercept for the Treatment of Pulmonary Arterial Hypertension., CONCLUSIONS: Treatment with sotatercept resulted in a reduction in pulmonary vascular resistance in patients receiving background therapy for pulmonary arterial hypertension., Sotatercept for the Treatment of Pulmonary Arterial Hypertension, CONCLUSIONS... | yes |
converted_3712 | Are stem cell transplants used to treat acute kidney injury? | Animal studies have shown that mesenchymal stromal cell (MSC) infusions improve acute kidney injury (AKI) outcomes when administered early after ischemic/reperfusion injury or within 24 hours after cisplatin administration., Early Diagnostic Markers for Detection of Acute Kidney Injury in Allogeneic Hematopoietic Stem ... | yes |
converted_2078 | Is the number of described human nuclear mutations less than 50000? | The number of known mutations in human nuclear genes, underlying or associated with human inherited disease, has now exceeded 100,000 in more than 3700 different genes (Human Gene Mutation Database)., The Human Gene Mutation Database (HGMD®) is a comprehensive collection of germline mutations in nuclear genes that unde... | no |
converted_3234 | Anaplasma phagocytophilum is an obligate gram-negative, intracellular bacterium, yes or no | The genus Anaplasma belonging to the Anaplasmataceae family (order Rickettsiales) comprises obligate intracellular Gram-negative bacteria of veterinary and public health importance. Six species and five types of strains genetically related are currently assigned to the genus Anaplasma including Anaplasma marginale, A. ... | yes |
converted_1370 | Are nucleosomes positioned at DNA replication origins? | yeast origins are characterized by an asymmetric pattern of positioned nucleosomes flanking the ACS. The origin sequences are sufficient to maintain a nucleosome-free origin; however, ORC is required for the precise positioning of nucleosomes flanking the origin., Here, we identify nucleosome occupancy as a likely cand... | no |
converted_2618 | Can non ubiquitinated Tomm20 promote mitophagy? | A total of 338 new targets were identified and from these we validated glycogen synthase kinase 3β (Gsk3β), which can phosphorylate α-synuclein, and translocase of outer mitochondrial membrane 20 (Tomm20), a mitochondrial translocase that, when ubiquitinated, promotes mitophagy, as SCFFbxo7substrates both in vitro and... | no |
converted_4025 | Is Lanabecestat effective for Alzheimer's disease? | INTRODUCTION: The APECS and AMARANTH trials showed that beta-secretase (BACE) inhibitors verubecestat and lanabecestat failed to slow cognitive and functional decline in individuals with prodromal or early Alzheimer's disease. , Conclusions and Relevance: Treatment with lanabecestat was well tolerated and did not slow ... | no |
converted_4586 | Is Mediator present at super enhancers? | BRD4 and Mediator were found to co-occupy thousands of enhancers associated with active genes., Master transcription factors and mediator establish super-enhancers at key cell identity genes, Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expr... | yes |
converted_3030 | Is avelumab effective for bladder cancer? | BACKGROUND: Avelumab has recently been approved by the Food and Drug Administration for the therapy of Merkel cell carcinoma and urothelial carcinoma., Six drugs including one CTLA-4 blocker (ipilimumab), two PD-1 blockers (nivolumab and pembrolizumab) and three PD-L1 blockers (atezolizumab, avelumab and durvalumab) ar... | yes |
converted_918 | Is oxalate renal excretion increased after bariatric surgery? | Despite the fact that bariatric surgery-induced weight loss is associated with a significant decrease in morbidity and mortality and improvement in renal function, bariatric surgery has recently been shown to be associated with a significant risk of nephrolithiasis. The main risk factor for nephrolithiasis is increased... | yes |
converted_2071 | Has the gorilla genome been determined? | Starting with human, chimpanzee, gorilla, and orangutan genomes, our software generated an exhaustive data set of 292 ALs (∼1 kb each) in ∼3 h. , We generated a high-quality assembly of the gorilla genome using single-molecule, real-time sequence technology and a string graph de novo assembly algorithm, Here we present... | yes |
converted_443 | Can we detect DNA strand asymmetries using dinucleotide relative abundance "genomic signatures"? | comparing the heterogeneities of bacterial genomes with respect to strand-independent first- and second-order features, (i) G + C content and (ii) dinucleotide relative abundance,, the concept of a genomic signature was introduced with the observation of species-type specific Dinucleotide Relative Abundance Profiles (D... | no |
converted_1283 | Is factor XI deficient in Hemophilia C? | Factor XI deficiency is a rare hematologic disorder. Hemophilia C (factor XI deficiency) affects both genders and it is usually asymptomatic,, Congenital factor XI deficiency (also known as the Rosenthal syndrome or hemophilia C), rare case of an acute cerebral aneurysm rupture in a patient with a known factor XI defic... | yes |
converted_3471 | Are the members of the KRAB-ZNF gene family promoting gene repression? | The proteins encoded by these genes, whose expression is often tissue-specific, act as epigenetic suppressors contributing to the addition of repressive chromatin marks and DNA methylation., Here, using a reporter system, we show that TRIM28/KRAB-ZNFs alter DNA methylation patterns in addition to H3K9me3 to cause stab... | yes |
converted_820 | Is Lysine-specific demethylase 1 (LSD1) a critical regulator of hematopoiesis? | Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells, shRNA-mediated knockdown of LSD1 in hematopoietic precursor cells resulted in altered SALL4 downstream gene expression and increased cellular activity, our data... | yes |
converted_1298 | Are there Conserved Noncoding Elements (CNEs) in invertebrate genomes? | Here, we use genome-wide comparisons between C. intestinalis and C. savignyi to identify putative urochordate cis-regulatory sequences. Ciona conserved non-coding elements (ciCNEs) are associated with largely the same key regulatory genes as vertebrate CNEs, We have identified Conserved Non-coding Elements (CNEs) in th... | yes |
converted_3937 | Are mucins glycosylated proteins? | Many members of the mucin family are evolutionarily conserved and are often aberrantly expressed and glycosylated in various benign and malignant pathologies leading to tumor invasion, metastasis, and immune evasion., Mucin is a glycoprotein that is the primary component of the mucus overlaying the epithelial tissues. ... | yes |
converted_1241 | Is poly (ADP- ribosylation) involved in transcriptional control? | Histone phosphorylation, ubiquitylation, SUMOylation and poly-ADP-ribosylation, as well as ATP-dependent nucleosome remodeling complexes, play equally pivotal roles in the maintenance of transcriptional fidelity, oly(ADP-ribose) polymerase-1 (PARP-1; EC 2.4.2.30) is an abundant nuclear protein that is involved in DNA r... | yes |
converted_1475 | Is aganglionic megacolon a feature of Down syndrome? | Down syndrome (DS) is recognized by characteristic facial features, intellectual disability, and an increased risk for cardiac malformations and duodenal atresia. Recently, Hirschsprung disease (HSCR), or congenital aganglionic megacolon, has been seen more often among patients with DS, Of the 17 patients with HD who w... | yes |
converted_450 | Can SUMO affect calcium homeostasis? | Increasing SUMOylation levels correlated inversely with calcium influx in sensory neurons., CRMP2 deSUMOylation by SUMO proteases SENP1 and SENP2 normalized calcium influx to those in the CRMP2AAA mutant., Thus, our results identify a novel role for SUMO modification in CRMP2/CaV2.2 signaling pathway, Moreover, SUMO1 o... | yes |
converted_1510 | Is gastro esophageal reflux related to burning mouth syndrome? | Our results suggest that there is no causal connection between LPR episodes and the occurrence of intraoral burning sensations in the examined patients., As reported below, although this symptom may well be diagnostically misleading, careful diagnosis based on clinical signs may distinguish patients with BMS from those... | no |
converted_766 | Does GC content vary markedly within a given isochore? | The isochore, a large DNA sequence with relatively small GC variance, is one of the most important structures in eukaryotic genomes., Isochores are large regions of relatively homogeneous nucleotide composition, Vertebrate genomes are comprised of isochores that are relatively long (>100 kb) regions with a relatively h... | no |
converted_2562 | Is subacute sclerosing panencephalitis caused by the Measles vaccine? | Subacute sclerosing panencephalitis (SSPE) is a potentially fatal complication of measles. , Subacute sclerosing panencephalitis (SSPE) is a fatal complication of measles. We reviewed California cases from 1998-2015 to understand risk f, Subacute sclerosing panencephalitis should be eliminated by measles vaccination, T... | no |
converted_4148 | Is the glucocorticoid receptor a transcription factor? | GR and KLF4, both pioneer transcription factors,, The glucocorticoid receptor (GR) is a ligand-binding dependent transcription factor that ultimately regulates vital biological processes and inflammation response through specific gene expression control, thus representing a notable drug target to explore. , The glucoco... | yes |
converted_286 | Is pregabalin effective for treatment of patients with restless leg syndrome? | CONCLUSIONS: This study demonstrated improvements in objective and subjective measures of sleep maintenance and sleep architecture with pregabalin compared with placebo and pramipexole. Effects of pregabalin on periodic limb movement arousal index were comparable to pramipexole. , CONCLUSIONS: Pregabalin provided signi... | yes |
converted_2491 | Has ATF4 transcription factor been linked to cancer and neoplastic transformation? | aken together, we discovered a novel axis of BCL10-regulated OSCC progression via STAT1/ATF4/S100P/P65 signaling, which could predict the prognosis of OSCC and will be beneficial for developing therapeutic strategy against advanced OSCC, s a result, the level of phosphorylated Eukaryotic Initiation Factor 2 alpha (eIF2... | yes |
converted_42 | Is irritable bowel syndrome more common in women with endometriosis? | CONCLUSIONS: Comorbid pain syndromes, mood conditions and asthma are common in adolescents and young women with endometriosis., There are many etiologies of pelvic pain that present with symptoms resembling those of endometriosis-associated pelvic pain that are not diagnosable with laparoscopy, such as interstitial cys... | yes |
converted_856 | Is Dicer part of the RISC loading complex? | Dicer is a component of the protein machinery (the RNA Induced Silencing Complex [RISC]) which is involved in catalyzing the formation of mature microRNAs from their precursors in the process of microRNA biogenesis., RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor co... | yes |
converted_3904 | Is Ixodes a species of tick? | ixodid ticks, ixodid ticks , ixodid ticks, tick, Ixodes ricinus, hard ticks (family Ixodidae), The two enzootic tick vectors, Ixodes affinis and Ixodes minor, rarely bite humans but are more important than the human biting "bridge" vector, Ixodes scapularis, in maintaining the enzootic spirochete cycle in nature., is ... | yes |
converted_1758 | Has Glucose-6-phosphate dehydrogenase (G6PD) deficiency an X-linked inheritance? | Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the commonest red cell enzymopathy in humans and has an X-linked inheritance. , This genetic defect shows sex linked inheritance and a marked heterogeneity., G6PD deficiency is the most common enzymopathy in the world. , Study of the deficiency pattern amongst fami... | yes |
converted_742 | Can mutations in Calmodulin cause ventricular fibrillation? | We characterized a family presenting with a history of ventricular fibrillation (VF) and sudden death without ECG or echocardiographic abnormalities at rest. Two siblings died suddenly at the ages of 9 and 10 years, and another two were resuscitated from out-of-hospital cardiac arrest with documented VF at age 10 and 1... | yes |
converted_3080 | Is treatment with Bacillus Calmette Guerin used for bladder cancer? | Intravesical Bacillus Calmette-Guerin (BCG) is the best treatment modality for progression of non-muscle invasive bladder cancer. , this result indicates that they may be used as putative biomarkers for monitoring changes in bladder carcinogenesis in response to BCG immunotherapy., response of urothelial precancerous l... | yes |
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