id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 55 21.3k | label stringclasses 2
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converted_2916 | Is there any role for HUWE1 in MYC signalling? | HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation., To determine the importance of HUWE1, we chose to examine its function in colorectal cancer, where it is mutated in up to 15 per cent of tumours. Modelling of identified mutations showed that... | yes |
converted_2266 | Are neurexins localized at pre-synapses? | Neurexins and neuroligins are two distinct families of single-pass transmembrane proteins localized at pre- and postsynapses, respectively. , presynaptic neurexins, best-characterized transsynaptic interactions are formed by presynaptic neurexins, which bind to diverse postsynaptic ligands., presynaptic neurexin[SEP] | yes |
converted_3952 | Has ubrogepant entered clinical phase III trials? | Ubrogepant (MK-1602) is a novel, oral, calcitonin gene-related peptide receptor antagonist in clinical development with positive phase III outcomes for acute treatment of migraine., A population pharmacokinetic model describing the effect of formulations was included in the E-R simulation framework to assess potential ... | yes |
converted_3231 | Is CD63 an exosomal marker? | f exosome marker proteins (e.g., CD63, Alix) , CD63 levels and acetylcholinesterase (AChE) activity were used as markers of exosome,, The results demonstrated these exosomes all expressed CD9, CD63, CD81, Alix[SEP] | yes |
converted_3183 | Are protamines ubiquitously expressed? | Protamines are nuclear proteins which are specifically expressed in haploid male germ cells.[SEP] | no |
converted_529 | Is TALEN being used on stem cells? | Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9., Genetic correction of patient-derived induced pluripotent stem cells (iPSCs) by TALENs or CRISPR-Cas9 holds promise for DMD gene therapy; however, the safety of such nuclease treatm... | yes |
converted_4655 | Is Erythropoietin effective for neuroprotection of Preterm Infants. | BACKGROUND: High-dose erythropoietin has been shown to have a neuroprotective effect in preclinical models of neonatal brain injury, and phase 2 trials have suggested possible efficacy; however, the benefits and safety of this therapy in extremely preterm infants have not been established., There was no significant dif... | no |
converted_3875 | Is MK-1602 a CGRP antagonist? | The aim of this trial was to evaluate the efficacy and tolerability of ubrogepant (MK-1602), a calcitonin gene-related peptide receptor antagonist (CGRP-RA), for the acute treatment of migraine., This trial supports ubrogepant's efficacy and provides further evidence that CGRP-RAs are viable options for the acute treat... | yes |
converted_1874 | Is there an association between Muenke Syndrome and FGFR3 gene mutation? | RESULTS: Forty-four with a positive FGFR3 mutation, median age 9 years, range 7 months to 52 years were enrolled. In addition, 10 unaffected siblings served as controls (5 males, 5 females; median age, 13 years; range, 3-18 years)., Muenke is a fibroblast growth factor receptor 3 (FGFR-3)-associated syndrome, which was... | yes |
converted_4178 | Do bacteria release extracellular vesicles? | Bacterial extracellular vesicles (EVs) are bilayered lipid membrane structures, bearing integral proteins and able to carry diverse cargo outside the cell to distant sites., Knowledge of the structure, molecular cargo and function of bacterial extracellular vesicles (BEVs) is primarily obtained from bacteria cultured i... | yes |
converted_3482 | Is PF-05190457 an inverse agonist of the ghrelin receptor? | Pharmacokinetics and pharmacodynamics of PF-05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects., To evaluate safety, tolerability and pharmacokinetics of oral PF-05190457, an oral ghrelin receptor inverse agonist, in healthy adults., PF-05190457 is a well-tolerated first-in-cl... | yes |
converted_166 | Are there any statistical methods for normalizing and identifying differential regions in histone modification ChIP-seq data? | ChIPnorm: a statistical method for normalizing and identifying differential regions in histone modification ChIP-seq libraries., In this paper we propose a two-stage statistical method, called ChIPnorm, to normalize ChIP-seq data, and to find differential regions in the genome, given two libraries of histone modificati... | yes |
converted_3383 | AhR ligands are attractive drug targets for pharmaceutical development due to their induction of Cyp1a1, yes or no? | Based on our review of the data, there is little evidence to support the indiscriminate exclusion of AhR activators/Cyp1a1 inducers from early drug developmental pipelines. We also found no evidence that short-term treatment with RMAhRLs produce "dioxin-like toxicity", However, recent discoveries of new AhR ligands wi... | yes |
converted_1948 | Do IEG create a ripple effect of transcription? | Rapid induction of immediate-early genes (IEGs) in response to growth factor stimulations is accompanied by co-upregulation of their neighbouring genes., Even in surrounding intergenic regions, transcriptional activation took place at the same time. , Here we show that intensive transcription at one locus frequently sp... | yes |
converted_409 | Does a linker histone exist in the yeast genome? | Hho1p is a bona fide linker histone, In Saccharomyces cerevisiae, HHO1 encodes a putative linker histone with very significant homology to histone H1, HHO1p may play a similar role to linker histones, but at restricted locations in the chromatin, The putative linker histone in Saccharomyces cerevisiae, Hho1p, has two r... | yes |
converted_2229 | Does PCSK9 (Proprotein convertase subtilisin/kexin type 9) binds with HDL-receptor (HDL-R)? | Recently it was revealed that the secreted Proprotein Convertase Subtilisin Kexin 9 (PCSK9) binds with LDL-receptor (LDL-R) causing its degradation in the lysosome with the result of LDL-C accumulating in the blood., The major goal of this study is to identify peptide/s from the catalytic domain of hPCSK9 that can bloc... | no |
converted_516 | Is there an association between TERT promoter mutation and survival of glioma patients? | Mutations lead to TERT upregulation and are associated with aggressive clinical behavior in glioblastomas., Kaplan-Meier's survival analysis showed that TERT promoter mutation (P=0.037), Isocitrate dehydrogenase (IDH) mutation (P<0.001), and 1p/19q codeletion (P<0.001) were associated with favorable overall survival (O... | yes |
converted_2205 | Does the Abelson-related gene (ARG) gene encode for a serine kinase? | One isoform of Arg/Abl2 tyrosine kinase is nuclear and the other seven cytosolic isoforms differently modulate cell morphology, motility and the cytoskeleton., The non-receptor tyrosine kinase Abelson related gene (Arg/Abl2) regulates cell migration and morphogenesis by modulating the cytoskeleton. , The human Arg (Abl... | no |
converted_3506 | Is mesothelioma caused by asbestos exposure? | Malignant mesothelioma is a rare and aggressive pleural or peritoneal tumour almost always caused by exposure to asbestos fibres, Exposure to asbestos can cause malignant mesothelioma 30-40 years after exposure., Malignant peritoneal mesothelioma is a rare, aggressive tumor arising from the peritoneal lining, induced b... | yes |
converted_2407 | Has the proteome of mice hippocampus been analysed? | We employed a discovery-based proteomic approach in subcellular fractions of hippocampal tissue from chronic intermittent alcohol (CIE)-exposed C57Bl/6J mice to gain insight into alcohol-induced changes in GluN2B signaling complexes. , We employed shotgun liquid chromatography-mass spectrometry (LC-MS) proteomic and m... | yes |
converted_1465 | Does triiodothyronine (T3) has cardiac angiogenic effects? | T3-induced cardiac sprouting angiogenesis in adult hypothyroid mice was associated with PDGF-BB, PDGFR-β and downstream activation of Akt., L-T3 significantly increased angiogenesis and cell survival and enhanced the expression of nuclear-encoded transcription factors involved in these processes., T(3) administration r... | yes |
converted_4352 | Does atemoya juice inhibit tye CYP3A4 enzyme? | Atemoya juice significantly inhibited CYP1A2 activity in human liver microsomes, but not the activities of CYP2C9 and CYP3A.[SEP] | no |
converted_1619 | Does triiodothyronine play a regulatory role in insulin secretion from pancreas? | Our findings establish that p43 is an important regulator of glucose homeostasis and pancreatic β-cell function and provide evidence for the first time of a physiological role for a mitochondrial endocrine receptor., The p43(-/-) mice had a major defect in insulin secretion both in vivo and in isolated pancreatic islet... | yes |
converted_1567 | Does low T3 negatively affect prognosis of patients after cardiac surgery? | ur findings suggest that the development of LCOS after congenital heart surgery is associated with decreased total and free T3, and increased IL-8 levels at 48 hours, and preoperative tT4 level is an independent predictor of LCOS., Low basal fT3 concentration can reliably predict the occurrence of postoperative AF in C... | yes |
converted_3714 | Is deletion at 6q24.2-26 associated with shorter survival for ovarian cancer patients? | Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients., Standard treatments for advanced high-grade serous ovarian carcinomas (HGSOCs) show significant side-effects and provide only short-term survival benefits due to disease recurrence. Thus, identification of novel pro... | no |
converted_334 | Is exome sequencing efficient for the detection of germline mutations? | Whole exome sequencing is an efficient and sensitive method for detection of germline mutations in patients with phaeochromcytomas and paragangliomas, Whole exome sequencing is sensitive, rapid and efficient for detection of PCC/PGL germline mutations., These results from deep sequencing demonstrate a higher mutational... | yes |
converted_733 | Is Sarcolipin a regulatory/inhibitory protein of the Calcium ATPase SERCA? | The activity of SERCA is regulated by two small, homologous membrane proteins called phospholamban (PLB, also known as PLN) and sarcolipin (SLN). Detailed structural information explaining this regulatory mechanism has been lacking, and the structural features defining the pathway through which cytoplasmic Ca(2+) enter... | yes |
converted_2106 | Does GATA-1 regulate ribosomal protein genes? | Mutations in exon 2 interfere with the synthesis of the full-length isoform of GATA-1 and lead to the production of a shortened isoform, GATA-1s. These mutations have been found in patients with Diamond-Blackfan anemia (DBA), a congenital erythroid aplasia typically caused by mutations in genes encoding ribosomal prote... | yes |
converted_2040 | Does Yersinia pestis causes a respiratory infection? | Inhalation of Yersinia pestis results in primary pneumonic plague, a highly lethal and rapidly progressing necrotizing pneumonia, Yersinia pestis causes the fatal respiratory disease pneumonic plague., Pulmonary infection by Yersinia pestis causes pneumonic plague, a rapidly progressing and often fatal disease., Pulmon... | yes |
converted_3363 | Is bortezomib a Proteasome inhibitor? | The proteasome-inhibitor bortezomib, The proteasome inhibitor bortezomib is effective for a variety of tumors, but not for GBM. , Proteasome inhibitor bortezomib , The proteasome inhibitor bortezomib, registered for Multiple Myeloma treatment, is currently explored for activity in solid tumors including non-small cell ... | yes |
converted_3806 | Does head ct increase brain tumor risk? | Excess relative risk of new brain tumor averaged 1.29 (95% confidence interval, 0.66-1.93) for pediatric patients exposed to one or more head CTs. Tumor incidence increased with number of pediatric head CTs in a dose-dependent manner, with measurable excess incidence even after a single scan. Converging evidence from e... | yes |
converted_1846 | Can Diabetes be caused by a defect in a potassium chanel? | Mutations in KATP channel genes can result in hypo- or hypersecretion of insulin, as in neonatal diabetes mellitus and congenital hyperinsulinism, respectively., To date, all patients affected by neonatal diabetes due to a mutation in the pore-forming subunit of the channel (Kir6.2, KCNJ11) are heterozygous for the mut... | yes |
converted_1658 | Does cucumber lower blood sugar in diabetics? | The ethanolic extract of Cucumis sativus Linn, Cucumis melo utilissimum Roxb, Cucumis melo Linn, Benincasa hispida Thunb Cogn and Tricosanthes anguina Nees, when administered in 250 mg/kg dose, orally to rats failed to lower blood sugar or to depress the peak value, after glucose load., Ethanolic extract of Tricosanthe... | yes |
converted_2662 | Does oncogene-induced DNA replication stress inhibit genomic instability? | Oncogene-induced DNA replication stress is thought to drive genomic instability in cancer., We propose that single-stranded DNA generated in response to oncogene-induced replication stress compromises the repair of deaminated cytosines and other damaged bases, leading to the observed SNS mutator phenotype.[SEP] | no |
converted_3129 | Has Hesperidin any role as a Neuroprotective Agent? | Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease, Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury, Neuroprotective Effects of Hesperidin on Cerebral Vasospasm, The neuro... | yes |
converted_4 | Is RANKL secreted from the cells? | Osteoprotegerin (OPG) is a soluble secreted factor that acts as a decoy receptor for receptor activator of NF-κB ligand (RANKL) , Osteoprotegerin (OPG) is a secreted glycoprotein and a member of the tumor necrosis factor receptor superfamily. It usually functions in bone remodeling, by inhibiting osteoclastogenesis thr... | yes |
converted_1354 | Has the presence of delayed enhancement been documented in athletes performing strenuous exercise? | Atypical findings such as marked cardiac dilation, reduced deformation, or small patches of delayed gadolinium enhancement may be commonly encountered in well-trained athletes, but, at present, the prognostic significance of such findings is unknown. , On CMR, DGE localized to the interventricular septum was identified... | yes |
converted_3970 | Does erenumab target the calcitonin gene-related peptide? | Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor (erenumab) and three targeting the calcitonin gene-related peptide (eptinezumab, fremanezumab, and galcanezumab).[SEP] | no |
converted_3486 | Are there lncRNAs that control the extent of neuronal outgrowth? | Regulation of Neuroregeneration by Long Noncoding RNAs., Here, we profiled gene expression following sciatic nerve crush in mice and identified long noncoding RNAs (lncRNAs) that act in the regenerating neurons and which are typically not expressed in other contexts. We show that two of these lncRNAs regulate the exten... | yes |
converted_3563 | Are genes that escape X-chromosome inactivation related to mental impairment? | Mutation screening of the MECP2 gene in a large cohort of 613 fragile-X negative patients with mental retardation., The first one, the double nucleotide substitution c.1162_1163delinsTA leading to a premature stop codon (p.Pro388X) was found in a female patient with random X-inactivation, presenting with borderline men... | yes |
converted_506 | Are there conserved noncoding elements identified between genomes of human and teleosts? | We report evidence for a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding elements (HCNEs), their developmental regulatory target genes, and phylogenetically and functio... | yes |
converted_420 | Are messenger RNA molecules epigenetically methylated? | The most abundant mRNA post-transcriptional modification is N(6)-methyladenosine (m(6)A), which has broad roles in RNA biology., N(6)-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate., Recently, methylation patterns have also been revealed ... | yes |
converted_4565 | Is Sotrovimab effective for COVID-19? | It seems that monoclonal antibodies (e.g., low dosage bamlanivimab, baricitinib, imatinib, and sotrovimab) are a better choice for treating severe or non-severe COVID-19 patients. , The Food and Drug Administration has granted emergency use authorization to sotrovimab for the treatment of mild to moderate COVID-19 in p... | yes |
converted_4344 | Does trimetazidine protect from myocardial injury after percutaneous coronary intervention? | After a median follow-up of 47·5 months (IQR 42·3-53·3), incidence of primary endpoint events was not significantly different between the trimetazidine group (700 [23·3%] patients) and the placebo group (714 [23·7%]; hazard ratio 0·98 [95% CI 0·88-1·09], p=0·73). When analysed individually, there were no significant di... | no |
converted_1281 | Is TNNI3K a cardiac-specific protein? | cardiomyocyte-specific kinase TNNI3K , We report that cardiac troponin I-interacting kinase (TNNI3K), a cardiomyocyte-specific kinase,, TNNI3K, a cardiac-specific kinase, , The cardiac troponin I-interacting kinase (TNNI3K), a novel cardiac specific kinase, is associated with cardiomyocyte hypertrophy, Human cardiac t... | yes |
converted_2669 | Is CXCL7 a chemokine? | CXCL7, a chemokine highly expressed in platelets, , Chemokine CXCL7 Heterodimers[SEP] | yes |
converted_181 | Is the abnormal dosage of ultraconserved elements disfavored in cancer cells? | Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cells., We begin by showing that depletion for UCEs characterizes the most recent large-scale human CNV datasets and then find that even newly formed de novo CNVs, which have passed through meiosis at most once, are signific... | no |
converted_909 | Does resveratrol reduce cardiac remodeling? | In conclusion, resveratrol attenuated cardiac oxidative damage and left ventricular remodeling and enhanced the decreased expression of SIRT1 in hearts of old rats with emphysema and thus might be a therapeutic modality for cardiac injury complicated in chronic obstructive pulmonary disease (COPD)., In conclusion, resv... | yes |
converted_1913 | Is avanafil indicated for treatment of erectile dysfunction? | CONTEXT: Avanafil (AVA) is used in the treatment of erectile dysfunction, but is reported for its poor aqueous solubility. , BACKGROUND: Phosphodiesterase 5 inhibitors (PDE5-Is) sildenafil, vardenafil, tadalafil and the recently approved avanafil represent the first-line choice for both on-demand and chronic treatment ... | yes |
converted_4408 | Does UBE4B promote renal cancer? | UBE4B might act as an oncogene in regulating RCC development. Therefore it could be served as an effective indicator to predict OS and a potential biomarker for targeted therapy of RCC patients.[SEP] | yes |
converted_835 | Is metabolic syndrome related with cardiovascular disease? | The metabolic syndrome (MetS) is characterized by a cluster of risk factors including central obesity, hypertension, dyslipidemia and insulin resistance, The MetS is associated with an increased risk for cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). , As a molecular link between metabolic signals, i... | yes |
converted_2088 | Are cutaneous porphyrias inherited with a recessive pattern? | Five of the porphyrias are low-penetrance autosomal dominant conditions in which clinical expression results from additional factors that act by increasing demand for haem or by causing an additional decrease in enzyme activity or by a combination of these effects, Molecular mechanisms of dominant expression in porphyr... | no |
converted_2007 | Is the mouse Sry gene locus free of repetitive sequences? | We demonstrate that the presence of long inverted repeats (IR) flanking the mouse Sry gene leads to the formation of the Sry circular transcript in cultured cells, Circularization requires the presence of both IR. As few as 400 complementary nt are necessary for this process, The presence of the IR does not significant... | no |
converted_3803 | Is Tcf3 associated with the Wnt pathway? | TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments, Furthermore, the role of miR-17 was because of its target gene TCF3 (transcription factor 3), a key transcription factor of canonical Wnt pathway., Co... | yes |
converted_764 | Is insulin-like growth factor-I (IGF-I) able to affect tendon protein synthesis in classic Ehlers-Danlos syndrome patients? | Tendon protein synthesis rate in classic Ehlers-Danlos patients can be stimulated with insulin-like growth factor-I, IGF-I injections significantly increased FSR values in cEDS patients but not in controls, In conclusion, baseline protein synthesis rates in connective tissue appeared normal in cEDS patients, and the pa... | yes |
converted_2436 | Is CREB a key memory protein? | Human cyclic AMP response element binding protein (CREB) transcription factor which plays a crucial role in memory, The activated CREB is implicated in the regulation of development, protection, learning, memory and plasticity in the nerve system. , A mouse genetic study showed that cAMP-responsive element-binding prot... | yes |
converted_146 | Is SLC22A3 expressed in the brain? | The organic cation transporter (OCT) 3 is widely expressed in various organs in humans, and involved in the disposition of many exogenous and endogenous compounds. Several lines of evidence have suggested that OCT3 expressed in the brain plays an important role in the regulation of neurotransmission. , The organic cati... | yes |
converted_2420 | SGOT is an abbreviation for an enzyme other wise known as alanine amino transferase, yes or no? | patients with aspartate amino transferase (SGOT), alanine amino transferase (SGPT),, Alanine amino transferase (SGPT), , aspartate aminotransferase (AST-SGOT), alanine amino-transferase (ALT-SGPT), Mean values of glutamate dehydrogenase (GDH), serum aspartate and alanine transferase (SGOT and SGPT), ornithine carbamoyl... | no |
converted_150 | Is PTEN involved in follicular thyroid carcinoma? | Two of the 259 patients (0.8%), with both follicular thyroid carcinoma and macrocephaly, were found to carry a germline mutation in the PTEN gene. The PTEN mutation frequency in unselected cases of follicular thyroid carcinoma was 4.8%, The frequency of germline pathogenic PTEN mutations in an unselected series of pati... | yes |
converted_4439 | Are circular RNAs implicated in diseases of the eye? | n this review, we summarized the function of circRNAs and indicated their roles in the pathogenesis of DR, which may provide new therapeutic targets for clinical treatment., This study aimed to determine whether circular RNAs (circRNAs) in whole blood could be served as novel non-invasive biomarkers for proliferative d... | yes |
converted_2455 | Is LDB1-mediated enhancer looping dependent on cohesin? | LDB1-mediated enhancer looping can be established independent of mediator and cohesin., Moreover, ENCODE data and our chromatin immunoprecipitation results indicate that cohesin is almost completely absent from validated and predicted LDB1-regulated erythroid enhancer-gene pairs. Thus, lineage specific factors largely ... | no |
converted_245 | Is the Drosophila Translational Control Element (TCE) involved in spermatogenesis? | Gene regulation in Drosophila spermatogenesis: analysis of protein binding at the translational control element TCE., We have previously identified a 12 nucleotide long sequence element, the TCE, that was demonstrated to be necessary for translational control of expression in the male germ line of Drosophila melanogast... | yes |
converted_282 | Is the Wnt protein modified by notum? | Notum deacylates Wnt proteins to suppress signalling activity., Kinetic and mass spectrometric analyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins and thus constitutes the first known extracellular protein deacylase., the Wnt inhibitor notum, ... | yes |
converted_1340 | Are there enhancer RNAs (eRNAs)? | active enhancers are transcribed, producing a class of noncoding RNAs called enhancer RNAs (eRNAs). eRNAs are distinct from long noncoding RNAs (lncRNAs), but these two species of noncoding RNAs may share a similar role in the activation of mRNA transcription, eRNAs may then facilitate enhancer-promoter interaction or... | yes |
converted_4125 | Is vocimagene amiretrorepvec effective for glioblastoma? | CONCLUSIONS: These results support an immune-related mechanism of action for Toca 511 and Toca FC, and suggest that molecular and immunologic signatures are related to clinical benefit from treatment., The median OS was 11.10 months for the Toca 511/FC group and 12.22 months for the control group (hazard ratio, 1.06; 9... | no |
converted_391 | Does the majority of the mitochondrial genomes abide to the second parity rule (PR2)? | a large number of mitochondrial genomes significantly deviate from the 2nd parity rule in contrast to the eubacterial ones, mitochondria may be divided into three distinct sub-groups according to their overall deviation from the aforementioned parity rule., The behaviour of the large majority of the mitochondrial genom... | no |
converted_3813 | Is aggrephagy a variant of autophagy? | The selective branch of autophagy that deals with identification, capture and degradation of protein aggregates is called aggrephagy., Mechanistic insights into aggrephagy, a selective basal autophagy process to clear misfolded protein aggregates, , , it is largely unknown how misfolded polypeptides form aggresomes and... | yes |
converted_1501 | Have germline variants been associated to colorectal cancer? | Overall, we identified aberrant transcripts in 8% of the patients (familial cases 30%; early-onset manifestation 21%). In eight of them, two different out-of-frame pseudoexons were found consisting of a 167-bp insertion from intron 4 in five families with a shared founder haplotype and a 83-bp insertion from intron 10 ... | yes |
converted_3829 | Is there any role of genotoxic pks + E. coli in cancer? | Mutational signature in colorectal cancer caused by genotoxic pks+, Various species of the intestinal microbiota have been associated with the development of colorectal cancer1,2, but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the p... | yes |
converted_3056 | As of Feb 2019, are major brain gangliosides a target for the treatment of Alzheimer's disease? | An understanding of the mechanism on the interaction of GM1 and Aβs in AD may contribute to the development of new neuroregenerative therapies for this disorder., Abnormal ganglioside metabolism also may occur in AD brains, Continuous intraventricular infusion of GM1 has recently been shown to have a significant benefi... | yes |
converted_3930 | Has the olive tree pollen proteome been studied? | Olive pollen is a major allergenic source worldwide due to its extensive cultivation. We have combined available genomics data with a comprehensive proteomics approach to get the annotated olive tree (Olea europaea L.) pollen proteome and define its complex allergenome. [SEP] | yes |
converted_4546 | Is METTL1 overexpression associated with better patient survival? | Here we find METTL1 is frequently amplified and overexpressed in cancers and is associated with poor patient survival. METTL1 depletion causes decreased abundance of m7G-modified tRNAs and altered cell cycle and inhibits oncogenicity. Conversely, METTL1 overexpression induces oncogenic cell transformation and cancer. ... | no |
converted_3144 | Is the protein Asporin related to disease? | Accumulating evidence demonstrates the involvement of asporin in OA pathogenesis., Asporin has been reported as a tumor suppressor in breast cancer, while asporin-activated invasion has been described in gastric cancer., Asporin has been implicated as an oncogene in various types of human cancers; , These results sugg... | yes |
converted_680 | Is signal transducer and activator of transcription-3 (STAT3) critical for tumor angiogenesis progression? | (STAT3) is critical for cancer progression by regulating tumor cell survival, proliferation, and angiogenesis. Herein, we investigated the regulation of STAT3 activation and the therapeutic effects of Icaritin, a prenyl flavonoid derivative from Epimedium Genus, in renal cell carcinoma (RCC). , Overall, these results... | yes |
converted_1409 | Does Apolipoprotein E (ApoE) have anti-inflammatory activity? | have previously reported that apolipoprotein E (apoE), a protein component of very-low-density lipoproteins (VLDL) and high-density lipoproteins and a potent plasma-borne atheroprotective factor, exerts anti-inflammatory activity in macrophages by switching the activation profile from M1 ("classic") to M2 ("alternativ... | yes |
converted_3237 | Is the crystal structure of Pim-1 available? | Recent crystallographic studies of Pim-1 have identified unique structural features but have not provided insight into how the kinase recognizes its target substrates. , a co-crystal structure of lead molecule (HS38) in complex with DAPK3, a dual Pim/DAPK3 inhibitor (HS56), The crystal structure of this compound with P... | yes |
converted_4703 | Does sphingosine-1 phosphoate suppress epiregulin? | S1P-induced FOXO1 and EREG gene expression suggests that the activation of S1P-S1PR axis may cooperate with gonadotropins in modulating follicle development., S1P-dependent CREB phosphorylation induced FOXO1 and the EGF-like epiregulin-encoding gene (EREG), confirming the exclusive role of gonadotropins and interleukin... | no |
converted_428 | Have gnotobiotic animal models been used for the study of bowel disease? | Host gene expression in the colon of gnotobiotic interleukin-2-deficient mice colonized with commensal colitogenic or noncolitogenic bacterial strains: common patterns and bacteria strain specific signatures., Specific pathogen-free (SPF), but not germfree (GF), interleukin (IL)-2-deficient (IL-2-/-) mice develop infl... | yes |
converted_3697 | Is SATB1 necessary for T-cell maturation? | Special AT-rich binding protein 1 (SATB1) nuclear protein, expressed predominantly in T cells, regulates genes through targeting chromatin remodeling during T-cell maturation., the transcription factor SATB1 that regulates the T-cell maturation, SATB1 is a transcriptional regulator controlling the gene expression that ... | yes |
converted_3799 | Can SMAD6 variants cause craniosynostosis? | SMAD6 variants in craniosynostosis: genotype and phenotype evaluation., Enrichment of heterozygous missense and truncating SMAD6 variants was previously reported in nonsyndromic sagittal and metopic synostosis, and interaction of SMAD6 variants with a common polymorphism nearBMP2 (rs1884302) was proposed to contribute ... | yes |
converted_1758 | Has Glucose-6-phosphate dehydrogenase (G6PD) deficiency an X-linked inheritance? | Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the commonest red cell enzymopathy in humans and has an X-linked inheritance. , This genetic defect shows sex linked inheritance and a marked heterogeneity., G6PD deficiency is the most common enzymopathy in the world. , Study of the deficiency pattern amongst fami... | yes |
converted_4461 | Is tivantinib effective for MET-high hepatocellular carcinoma? | BACKGROUND: Tivantinib (ARQ 197), a selective, oral MET inhibitor, improved overall survival and progression-free survival compared with placebo in a randomised phase 2 study in patients with high MET expression (MET-high) hepatocellular carcinoma previously treated with sorafenib., INTERPRETATION: Tivantinib did not i... | no |
converted_2156 | Do circRNAs remain untranslated? | We demonstrate that the circular RNA circ-Foxo3 was highly expressed in non-cancer cells and were associated with cell cycle progression, Ectopic expression of circ-Foxo3 repressed cell cycle progression by binding to the cell cycle proteins cyclin-dependent kinase 2 (also known as cell division protein kinase 2 or CDK... | no |
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