id stringlengths 11 14 | sentence1 stringlengths 20 168 | sentence2 stringlengths 55 19.7k | label stringclasses 2
values |
|---|---|---|---|
converted_1270 | Can administration of the thyrotropin releasing hormone reduce fatigue in cancer patients? | TRH administration was associated with significant improvement (p < 0.05) in fatigue levels as measured by the Visual Analog Scale-Energy (VAS-E), was associated with significant (p < 0.05) improvement in sleep disturbances and improved quality of life. , This decrease in CRP level with TRH administration was associate... | yes |
converted_1489 | Is there any role for long noncoding RNAs in adipogenesis? | Long noncoding RNAs regulate adipogenesis., Here we profiled the transcriptome of primary brown and white adipocytes, preadipocytes, and cultured adipocytes and identified 175 lncRNAs that are specifically regulated during adipogenesis. Many lncRNAs are adipose-enriched, strongly induced during adipogenesis, and bound ... | yes |
converted_1052 | Is Propofol used for short-term sedation? | The current study explores the incidence and content of dreaming during short-term sedation with sevoflurane or propofo, Propofol is the sedative most frequently used for short-term sedation and the weaning phase, whereas benzodiazepines are the preferred substances for medium- and long-term sedation., Performance of t... | yes |
converted_1510 | Is gastro esophageal reflux related to burning mouth syndrome? | Our results suggest that there is no causal connection between LPR episodes and the occurrence of intraoral burning sensations in the examined patients., As reported below, although this symptom may well be diagnostically misleading, careful diagnosis based on clinical signs may distinguish patients with BMS from those... | no |
converted_248 | Is low T3 syndrome a prognostic marker in patients with renal insufficiency? | Low T3 was particularly common (44.3 %), and clearly associated with increased 6- and 12-month mortality and decreased overall survival (log rank test, P=0.007). , Increased rT3 may be more common in ESRD patients than previously described, and together with decreased T3 it may serve as an indicator of poor prognosis i... | yes |
converted_1913 | Is avanafil indicated for treatment of erectile dysfunction? | CONTEXT: Avanafil (AVA) is used in the treatment of erectile dysfunction, but is reported for its poor aqueous solubility. , BACKGROUND: Phosphodiesterase 5 inhibitors (PDE5-Is) sildenafil, vardenafil, tadalafil and the recently approved avanafil represent the first-line choice for both on-demand and chronic treatment ... | yes |
converted_2101 | Is Obeticholic Acid used for treatment of Primary Biliary Cholangitis? | Obeticholic acid in primary biliary cholangitis., In a double-blind, randomized, placebo-controlled study including 217 patients with primary biliary cholangitis, the authors show that obeticholic acid (a potent farnesoid X agonist) administered with ursodeoxycholic acid or as monotherapy significantly decreases serum ... | yes |
converted_944 | Has protein citrullination been implicated in rheumatoid arthritis? | : Citrullination has become a hot topic within recent years due to its involvement in diseases such as rheumatoid arthritis (RA), multiple sclerosis and fibrosis. , Current literature suggests that increased levels of citrullinated proteins are found in several if not all inflammatory diseases. , Antibodies directed ag... | yes |
converted_2876 | Does tremelimumab improve survival of mesothelioma patients? | BACKGROUND: Tremelimumab, an anti-CTLA4 monoclonal antibody, initially showed good activity when used alone in patients with mesothelioma, but did not improve the overall survival of patients who failed on first-line or second-line chemotherapy compared with placebo in the DETERMINE study. , INTERPRETATION: The combina... | no |
converted_1978 | Do histone variant mH2A (macro-H2A) levels decrease upon differentiation? | Through manipulation of macroH2A isoforms, we further demonstrate that macroH2A2 is the predominant barrier to reprogramming., In particular, we find macroH2A isoforms to be highly enriched at target genes of the K27me3 demethylase, Utx, which are reactivated early in iPS reprogramming, Therefore, we propose that macr... | no |
converted_220 | Has depression been shown to be a predictor of frailty? | significant role of frailty as a predictor of depression in a relatively younger old Chinese population, significant relationships between frailty and depressive symptoms and mortality at 1 year, These findings suggest that malnutrition is a major predictor of frailty or the "failure to thrive" syndrome in older person... | yes |
converted_3284 | Do de novo truncating mutations in WASF1 cause cancer? | De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures., Here, using exome sequencing and whole-genome sequencing, we identified three de novo truncating mutations in WAS protein family member 1 (WASF1) in five unrelated individuals with moderate to profound intellectual disability with autis... | no |
converted_3829 | Is there any role of genotoxic pks + E. coli in cancer? | Mutational signature in colorectal cancer caused by genotoxic pks+, Various species of the intestinal microbiota have been associated with the development of colorectal cancer1,2, but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the p... | yes |
converted_3952 | Has ubrogepant entered clinical phase III trials? | Ubrogepant (MK-1602) is a novel, oral, calcitonin gene-related peptide receptor antagonist in clinical development with positive phase III outcomes for acute treatment of migraine., A population pharmacokinetic model describing the effect of formulations was included in the E-R simulation framework to assess potential ... | yes |
converted_4696 | Do Afamin bind Vitamin E? | The plasma glycoprotein afamin has been previously identified as an alternative carrier protein for vitamin E in extravascular fluids such as plasma and cerebrospinal, ovarian follicular, and seminal fluids., afamin, a vitamin E-binding protein in human plasma, the human vitamin E-binding protein afamin, Afamin is a pl... | yes |
converted_4679 | Is there any role of the 'Greek islands' in olfactory receptor choice? | Chromatin conformation capture using in situ Hi-C on fluorescence-activated cell-sorted olfactory sensory neurons and their progenitors shows that olfactory receptor gene clusters from 18 chromosomes make specific and robust interchromosomal contacts that increase with differentiation of the cells. These contacts are o... | yes |
converted_253 | Can life style changes reduce oxidative stress | The CFS group had an unfavorable lipid profile and signs of oxidative stress induced damage to lipids and proteins. These results might be indicative of early proatherogenic processes in this group of patients who are otherwise at low risk for atherosclerosis. Antioxidant treatment and life style changes are indicated ... | yes |
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