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converted_4560 | Is serotonin transported by platelets? | activated platelets, which carry peripheral serotonin,, Platelet serotonin response was measured by serotonin augmented platelet aggregation and platelet serotonin receptor density. , SERT was studied in the 1970s and 1980s using membrane vesicles isolated from blood platelets., platelet-dense granules contain neurotr... | yes |
converted_1853 | Could hypophosphatemic rickets cause craniosynostosis? | This study examines a series of patients with hypophosphatemic rickets and craniosynostosis to characterize the clinical course and associated craniofacial anomalies. , Hypophosphatemic rickets and craniosynostosis: a multicenter case series., A 20-year retrospective review identified patients with hypophosphatemic ric... | yes |
converted_3515 | Can brain derived exosomes carry APP molecules? | Here, we show that small lipid vesicles called exosomes, secreted in the extracellular milieu by cortical neurons, carry endogenous APP, these exosomes contained APP and were capable of efficiently transferring APP to normal primary neurons. , Accumulating evidence has demonstrated that exosomes are associated with amy... | yes |
converted_2131 | Is POLD3 essential for mouse development? | The Pold3 gene encodes a subunit of the Polδ DNA polymerase complex. Pold3 orthologs are not essential in Saccharomyces cerevisiae or chicken DT40 cells, but the Schizosaccharomyces pombe ortholog is essential. POLD3 also has a specialized role in the repair of broken replication forks, suggesting that POLD3 activity c... | yes |
converted_2461 | Does Evolocumab improve cognitive function? | Conclusions In a randomized trial involving patients who received either evolocumab or placebo in addition to statin therapy, no significant between-group difference in cognitive function was observed over a median of 19 months. , Results A total of 1204 patients were followed for a median of 19 months; the mean (±SD) ... | no |
converted_4619 | Do we find bacteriophages in the gut? | a multitude of symbiotic bacteria and bacteriophages are decreased in abundance in patients with COVID-19, Bacterial viruses (bacteriophages, phages) of the gut have increasingly become a focus in microbiome studies, with an understanding that they are likely key players in health and disease., Already without exogenou... | yes |
converted_4100 | Are synonymous sites in primates and rodents functionally constrained? | To resolve this contradiction between expectations and observations, we used processed pseudogenes as a model for strict neutral evolution, and estimated selective constraint on synonymous sites using the rate of substitution at pseudosynonymous and pseudononsynonymous sites in pseudogenes as the neutral expectation. A... | no |
converted_2789 | Can gene therapy restore auditory function? | Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c., We demonstrate recovery of gene and protein expression, restoration of sensory cell function, rescue of complex auditory function and recovery of hearing and balance behavior to near wild-type levels. The data represent ... | yes |
converted_1169 | Have microRNAs been implicated in pharmacogenomics? | A major discovery is the ability of miRNAs to determine the efficacy of drugs, which has given rise to the field of 'miRNA pharmacogenomics' through 'Pharmaco-miRs'. miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function., The potential modulation of toxicology-... | yes |
converted_1828 | Is Migalastat used for treatment of Fabry Disease? | Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study., BACKGROUND: Fabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, resulting in α-galactosidase (α-Gal) deficiency and accumulatio... | yes |
converted_2007 | Is the mouse Sry gene locus free of repetitive sequences? | We demonstrate that the presence of long inverted repeats (IR) flanking the mouse Sry gene leads to the formation of the Sry circular transcript in cultured cells, Circularization requires the presence of both IR. As few as 400 complementary nt are necessary for this process, The presence of the IR does not significant... | no |
converted_3348 | Is Figitumumab effective for non-small cell lung cancer? | A phase III study failed for carboplatin, paclitaxel, with or without figitumumab in first-line treating metastatic non-small cell lung cancer (NSCLC)., CONCLUSION: Adding figitumumab to standard chemotherapy failed to increase OS in patients with advanced nonadenocarcinoma NSCLC., Median OS was 8.6 months for figitumu... | no |
converted_676 | Has proteomics been used in the study of Pick's disease? | In Pick's disease, increased AGE, CML, CEL, HNE and MDAL bands of about 50 kDa were observed in the frontal cortex (but not in the occipital cortex) in association with increased density of glial acidic protein bands., Thus, brain and cerebrospinal fluid (CSF) samples from patients with Alzheimer's disease, Down syndro... | yes |
converted_2459 | Is there any link between ERCC1-XPF and cohesin? | ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes., Using an in vivo biotinylation tagging approach in mice, we show that the nucleotide excision repair (NER) structure-specific endonuclease ERCC1-XPF complex interacts with the insulator binding protein CTCF, the co... | yes |
converted_1910 | Could plasmepsins be used as targets for developing anti-malaria drugs? | Fighting malaria: structure-guided discovery of nonpeptidomimetic plasmepsin inhibitors., Given that the parasite needs the resulting amino acid building blocks for its growth and development, plasmepsins are an important antimalarial drug target. , Due to early crystallographic evidence, plasmepsin II (Plm II) emerged... | yes |
converted_4461 | Is tivantinib effective for MET-high hepatocellular carcinoma? | BACKGROUND: Tivantinib (ARQ 197), a selective, oral MET inhibitor, improved overall survival and progression-free survival compared with placebo in a randomised phase 2 study in patients with high MET expression (MET-high) hepatocellular carcinoma previously treated with sorafenib., INTERPRETATION: Tivantinib did not i... | no |
converted_2016 | Is ocular melanosis a risk factor for uveal melanoma? | Ocular/oculodermal (oculo[dermal]) melanocytosis is a congenital periocular pigmentary condition that can lead to the development of uveal melanoma, estimated at 1 in 400 affected patients., Melanosis oculi is often underestimated as a risk factor for uveal melanoma and glaucoma. Ophthalmic surveillance, every 6 or 12 ... | yes |
converted_3245 | Is the Fluzone intradermal and the Fluzone intradermal quadrivalent vaccine produced by different companies? | An intradermal version of Fluzone® split-virion inactivated trivalent influenza vaccine, containing 9 µg hemagglutinin per strain of A/H1N1, A/H3N2, and one B lineage virus (Fluzone Intradermal, Sanofi Pasteur), became available in the US during the 2011-2012 influenza season for adults 18-64 years of age. In advance o... | no |
converted_3899 | Is erabutoxin b usually found in plants? | The variants are the curaremimetic toxin alpha from Naja nigricollis and erabutoxin a or b from Laticauda semifasciata, The three-dimensional structure of erabutoxin b, a short-chain neurotoxic peptide purified from the venom of the sea snake Laticauda semifasciata, , THe characteristic feature of the crystal structure... | no |
converted_835 | Is metabolic syndrome related with cardiovascular disease? | The metabolic syndrome (MetS) is characterized by a cluster of risk factors including central obesity, hypertension, dyslipidemia and insulin resistance, The MetS is associated with an increased risk for cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). , As a molecular link between metabolic signals, i... | yes |
converted_1729 | Are mutations in the STXBP1 gene associated with epilepsy? | Folinic acid responsive epilepsy in Ohtahara syndrome caused by STXBP1 mutation., A novel mutation in STXBP1 gene in a child with epileptic encephalopathy and an atypical electroclinical pattern., Mutations in STXBP1 gene, encoding the syntaxin binding protein 1, have been recently described in Ohtahara syndrome, or ea... | yes |
converted_3552 | Is the BAGEL algorithm used for arrayed CRISPR screens? | BAGEL: a computational framework for identifying essential genes from pooled library screens., The adaptation of the CRISPR-Cas9 system to pooled library gene knockout screens in mammalian cells represents a major technological leap over RNA interference, the prior state of the art. New methods for analyzing the data a... | no |
converted_579 | Is there any link between the aurora B kinase and the polycomb protein ring1B? | The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes., We show that the Aurora B kinase and the polycomb protein Ring1B have essential roles in regulating transcriptionally active genes in quiescent lymphocytes. Ring1B and Aurora B bind to a wide range of act... | yes |
converted_831 | Have 5q35 microdeletions been implicated in Sotos syndrome development? | Loss-of-function mutations of NSD1 and 5q35 microdeletions encompassing NSD1 are a major cause of Sotos syndrome (Sos), which is characterized by overgrowth, macrocephaly, characteristic facies, and variable intellectual disability (ID), We observed a novel 3.5 Mb 5q subtelomeric deletion in a 3-year-old girl with deve... | yes |
converted_3323 | Is BNN20 involved in Parkinson's disease? | Neurotrophic factors are among the most promising treatments aiming at slowing or stopping and even reversing Parkinson's disease (PD). However, in most cases, they cannot readily cross the human blood-brain-barrier (BBB). Herein, we propose as a therapeutic for PD the small molecule 17-beta-spiro-[5-androsten-17,2'-ox... | yes |
converted_1733 | Is mitofusin 2 a receptor for parkin? | Recent work demonstrates that a phosphorylated form of the mitochondrial fusion protein Mitofusin 2 serves as a receptor for Parkin translocation to damaged mitochondria., We show that the mitochondrial outer membrane guanosine triphosphatase mitofusin (Mfn) 2 mediates Parkin recruitment to damaged mitochondria. , Mfn2... | yes |
converted_2795 | Is chlorotoxin a peptide? | chlorotoxin peptide , Chlorotoxin (CTX) is a 36-amino-acid disulfide-containing peptide derived from the venom of the scorpion Leiurus quinquestriatus., The mature Odontobuthus doriae chlorotoxin peptide has a 35-amino-acid residue and four disulfide bounds. , Chlorotoxin (CTX), a disulfide-rich peptide from the scorpi... | yes |
converted_1968 | Is infertility characteristic of individuals with Fanconi anemia? | PALB2 links BRCA1 and BRCA2 in homologous recombinational repair of DNA double strand breaks (DSBs). Mono-allelic mutations in PALB2 increase the risk of breast, pancreatic, and other cancers, and biallelic mutations cause Fanconi anemia (FA). , Moreover, mutant males showed reduced fertility due to impaired meiosis an... | yes |
converted_2390 | Is Loss of function one of the cardinal signs of inflammation? | The concept of the four cardinal signs of acute inflammation comes from antiquity as rubor et tumor cum calore et dolore, (redness and swelling with heat and pain) extended later by functio laesa (loss of function)., As early as 2000 years ago, the Roman encyclopaedist Aulus Cornelius Celsus recognised four cardinal si... | yes |
converted_2266 | Are neurexins localized at pre-synapses? | Neurexins and neuroligins are two distinct families of single-pass transmembrane proteins localized at pre- and postsynapses, respectively. , presynaptic neurexins, best-characterized transsynaptic interactions are formed by presynaptic neurexins, which bind to diverse postsynaptic ligands., presynaptic neurexin | yes |
converted_3736 | Is αCGRP a member of the CGRP family? | αCGRP, another amyloidogenic member of the CGRP family., Therefore, in this work, we investigated the amyloidogenic profile of αCGRP, a 37-residue-long peptide hormone, utilizing both biophysical experimental techniques and Molecular Dynamics simulations. These efforts unravel a novel amyloidogenic member of the CGRP f... | yes |
converted_1955 | Does oculocutaneous albinism show an autosomal recessive inheritance? | Oculocutaneous albinism (OCA) is an autosomal recessive disorder characterized by hypopigmentation in eyes, hair and skin, accompanied with vision loss. , Oculocutaneous albinism (OCA) is an autosomal recessive hereditary pigmentation disorder affecting humans and several other animal species. , Oculocutaneous albinism... | yes |
converted_4489 | Is Mical an oxidoreductase? | the MICALs, which are flavoprotein monooxygenase/hydroxylase enzymes that associate with flavin adenine dinucleotide (FAD) and use the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH) in Redox reactions, MICAL is an oxidoreductase, We have recently identified a new family of multidomain oxidoreductase (red... | yes |
converted_2156 | Do circRNAs remain untranslated? | We demonstrate that the circular RNA circ-Foxo3 was highly expressed in non-cancer cells and were associated with cell cycle progression, Ectopic expression of circ-Foxo3 repressed cell cycle progression by binding to the cell cycle proteins cyclin-dependent kinase 2 (also known as cell division protein kinase 2 or CDK... | no |
converted_415 | Can protein coding exons originate from ALU sequences? | The Alu element has been a major source of new exons during primate evolution. Thousands of human genes contain spliced exons derived from Alu elements., More than 25% of Alu exons analyzed by RNA-Seq have estimated transcript inclusion levels of at least 50% in the human cerebellum, indicating widespread establishment... | yes |
converted_297 | Are cyclophilins proteins that bind to prolines? | Cyclophilins are ubiquitously expressed proteins that bind to prolines and can catalyse cis/trans isomerization of proline residues., a characteristic of the cyclophilin family of proteins that bind prolines and often act as cis-trans peptidyl-prolyl isomerases. , The cyclophilins are widely expressed enzymes that cata... | yes |
converted_356 | Is the yeast Μac1 transcription factor induced upon copper deficiency? | Low-affinity copper transporter CTR2 is regulated by copper-sensing transcription factor Mac1p in Saccharomyces cerevisiae., The copper-depletion induced CTR2 transcription can be abrogated by genetic deletion of copper-sensing transcription factor Mac1p, Taken together, our results suggest that Mac1p can activate the ... | yes |
converted_523 | Is stop codon bypass possible? | In 1999, proof-of-concept for treating these disorders was obtained in a mouse model of muscular dystrophy, when administration of aminoglycosides restored protein translation by inducing the ribosome to bypass a PTC., Aminoglycosides can bypass nonsense mutations and are the prototypic agents for translational bypass ... | yes |
converted_3162 | Is actin present in the nucleus? | Moreover, inhibition of ATM kinase or deficiency in nuclear actin polymerization causes carcinogenic RET/PTC chromosome rearrangements after DSBs induction in human cells., Our findings establish that nuclear actin-based mobility shapes chromatin organization by generating repair domains that are essential for homolog... | yes |
converted_2407 | Has the proteome of mice hippocampus been analysed? | We employed a discovery-based proteomic approach in subcellular fractions of hippocampal tissue from chronic intermittent alcohol (CIE)-exposed C57Bl/6J mice to gain insight into alcohol-induced changes in GluN2B signaling complexes. , We employed shotgun liquid chromatography-mass spectrometry (LC-MS) proteomic and m... | yes |
converted_3806 | Does head ct increase brain tumor risk? | Excess relative risk of new brain tumor averaged 1.29 (95% confidence interval, 0.66-1.93) for pediatric patients exposed to one or more head CTs. Tumor incidence increased with number of pediatric head CTs in a dose-dependent manner, with measurable excess incidence even after a single scan. Converging evidence from e... | yes |
converted_345 | Are circRNAs associated with diseases and traits? | Circ2Traits: a comprehensive database for circular RNA potentially associated with disease and traits., Circular RNAs play a crucial role in fine tuning the level of miRNA mediated regulation of gene expression by sequestering the miRNAs. Their interaction with disease associated miRNAs indicates that circular RNAs are... | yes |
converted_918 | Is oxalate renal excretion increased after bariatric surgery? | Despite the fact that bariatric surgery-induced weight loss is associated with a significant decrease in morbidity and mortality and improvement in renal function, bariatric surgery has recently been shown to be associated with a significant risk of nephrolithiasis. The main risk factor for nephrolithiasis is increased... | yes |
converted_3130 | Are apoE mimetics being considered as a treatment against Alzheimer's disease? | The apolipoprotein-E-mimetic COG112 protects amyloid precursor protein intracellular domain-overexpressing animals from Alzheimer's disease-like pathological features., Studies show that administration of apolipoprotein E (apoE) and apoE-derived small peptide mimetics protect AD mouse models against these AD-like featu... | yes |
converted_1145 | Could RG7112 be used as cancer therapy? | RG7112 is a potent and selective member of the nutlin family of MDM2 antagonists currently in phase I clinical studies., Our findings offer a preclinical proof-of-concept that RG7112 is effective in treatment of solid tumors expressing wild-type p53., On the other hand, JNJ-26854165, a novel tryptamine derivative and R... | yes |
converted_844 | Is there a genome-wide technique for the detection of R-loop formation? | Genome-wide analysis of fragile sites by chromatin immunoprecipitation (ChIP) and microarray (ChIP-chip) of phosphorylated H2A in these mutants supported a transcription-dependent mechanism of DNA damage characteristic of R loops, We have used a bisulfite-sensitivity assay to demonstrate genome-wide increase in the occ... | yes |
converted_3602 | Has istadefylline been considered as a treatment for Parkinson's disease? | Istradefylline (ISD) is a new drug developed for the treatment of Parkinson's disease (PD). It is an adenosine receptor A2A antagonists that will represent an important option for patients with advanced PD where it has been demonstrated efficacy in decreasing daily OFF time and is well tolerated. , The objective of thi... | yes |
converted_813 | Does a selective sweep increase genetic variation? | An East African population that gave rise to non-Africans underwent a selective sweep affecting the subcentromeric region where MTMR8 is located. This and similar sweeps in four other regions of the X chromosome, documented in the literature, effectively reduced genetic diversity of non-African chromosomes, a selective... | no |
converted_1520 | Is there any data to suggest that TRH (thyrotropin releasing hormone) administration can improve symptom severity of amyotrophic lateral sclerosis patients? | These central nervous system (CNS)-mediated effects provide the rationale for use of TRH and its analogs in the treatment of brain and spinal injury, and CNS disorders like schizophrenia, Alzheimer's disease, epilepsy, amyotrophic lateral sclerosis, Parkinson's disease, depression, shock and ischemia., The Effect of TR... | yes |
converted_2858 | Has Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) been reported to be a plasminogen receptor in pathogenic bacteria? | binding of plasminogen (Plg) to bacterial surfaces, as it has been shown that this interaction contributes to bacterial adhesion to host cells, invasion of host tissues, and evasion of the immune system. Several bacterial proteins are known to serve as receptors for Plg including glyceraldehyde-3-phosphate dehydrogena... | yes |
converted_3875 | Is MK-1602 a CGRP antagonist? | The aim of this trial was to evaluate the efficacy and tolerability of ubrogepant (MK-1602), a calcitonin gene-related peptide receptor antagonist (CGRP-RA), for the acute treatment of migraine., This trial supports ubrogepant's efficacy and provides further evidence that CGRP-RAs are viable options for the acute treat... | yes |
converted_4177 | Should cerebrolysin be used for aneurysmal subarachnoid hemorrhage? | No significant difference was detected in the proportion of patients with favorable six-month GOSE in either study group (odds ratio (OR): 1.49; 95% confidence interval (CI): 0.43-5.17). Secondary functional outcome measures for favorable six-month recovery i.e. a mRS of 0 to 3 (OR: 3.45; 95% CI 0.79-15.01) were compar... | no |
converted_1408 | Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) cause sudden cardiac death? | Here we refine our approach, and apply it to novel variants found in 2266 patients across two large cohorts with inherited sudden death syndromes, namely catecholaminergic polymorphic ventricular tachycardia (CPVT) or Brugada syndrome (BrS)., Calsequestrin-associated catecholaminergic polymorphic ventricular tachycardi... | yes |
converted_4244 | Is Adamts18 deficiency associated with cancer? | Adamts18 deficiency promotes colon carcinogenesis by enhancing β-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer., ADAMTS18 is a novel tumor suppressor and is critical to the pathology of human colorectal cancer. However, the underlying mechanism is not cl... | yes |
converted_2135 | Are hepadnaviral minichromosomes free of nucleosomes? | Several nucleosome-protected sites in a region of the DHBV genome [nucleotides (nt) 2000 to 2700], known to harbor various cis transcription regulatory elements, were consistently identified in all DHBV-positive liver samples., In addition, we observed other nucleosome protection sites in DHBV minichromosomes that may ... | no |
converted_2425 | Are there mammalian promoters with distal enhancer functions? | Genome-wide characterization of mammalian promoters with distal enhancer functions., Gene expression in mammals is precisely regulated by the combination of promoters and gene-distal regulatory regions, known as enhancers. Several studies have suggested that some promoters might have enhancer functions. However, the ex... | yes |
converted_784 | Can NXY-059 be used for treatment of acute ischemic stroke patients? | Even when the international recommendations for preclinical stroke research, the Stroke Academic Industry Roundtable (STAIR) criteria, were followed, we have still seen limited success in the clinic, examples being NXY-059 and haematopoietic growth factors which fulfilled nearly all the STAIR criteria, This occurred du... | no |
converted_543 | Is the gene DUX4 epigenetically regulated in somatic cells? | There are several genes on chromosome 4q35 region including DUX4 within D4Z4 repeats. Transcription of these genes is usually repressed by epigenetic modifications of this chromosomal region and also accumulation of transcriptional repressors to the repeat array., Recent studies provide compelling evidence that a retro... | yes |
converted_3340 | Is MLL3 part of the ASCOM complex? | MLL3 as part of ASCOM complex, MLL3 as part of activating signal cointegrator-2 -containing complex (ASCOM) | yes |
converted_2176 | Is dexamethasone recommended for treatment of intracerebral hemorrhage? | Dexamethasone and other glucocorticoids should be avoided. , During the third interim analysis, the death rate at the 21st day was identical in the two groups (dexamethasone vs. placebo, 21 of 46 vs. 21 of 47; chi-square = 0.01, P = 0.93). In contrast, the rate of complications (mostly infections and complications of d... | no |
converted_4114 | Is YKL-40 used as a biomarker for Alzheimer's disease? | Recently, cerebrospinal fluid (CSF) YKL-40 levels were reported to be a promising candidate biomarker of glial inflammation in Alzheimer's disease (AD). , Disease groups differed between them except AD versus FTD for YKL-40. , YKL-40 appears to be a more reliable biomarker in neurological diseases than NSE. | yes |
converted_4065 | Is ofatumumab effective for multiple sclerosis? | Anti-CD20 Agents for Multiple Sclerosis: Spotlight on Ocrelizumab and Ofatumumab., Ofatumumab, a fully human anti-CD20 monoclonal antibody, that binds a distinct epitope, has been further investigated in phase 3 trials for relapsing forms of MS. , Conclusion: Ofatumumab offers beneficial outcomes for RMS by reducing re... | yes |
converted_1739 | Is there a relationship between thyroid hormone altered metabolism and coronary artery disease? | The results showed that higher levels of TSH within the reference range were independently associated with the presence of CAD only among subjects less than or equal to 65 years old, suggesting age might influence the relationship., FT3 levels within the normal range were inversely correlated with the presence and seve... | yes |
converted_286 | Is pregabalin effective for treatment of patients with restless leg syndrome? | CONCLUSIONS: This study demonstrated improvements in objective and subjective measures of sleep maintenance and sleep architecture with pregabalin compared with placebo and pramipexole. Effects of pregabalin on periodic limb movement arousal index were comparable to pramipexole. , CONCLUSIONS: Pregabalin provided signi... | yes |
converted_2463 | Can Logic Alignment Free (LAF) be used for bacterial genomes classification? | LAF: Logic Alignment Free and its application to bacterial genomes classification., In this paper, we present Logic Alignment Free (LAF), a method that combines alignment-free techniques and rule-based classification algorithms in order to assign biological samples to their taxa. This method searches for a minimal subs... | yes |
converted_248 | Is low T3 syndrome a prognostic marker in patients with renal insufficiency? | Low T3 was particularly common (44.3 %), and clearly associated with increased 6- and 12-month mortality and decreased overall survival (log rank test, P=0.007). , Increased rT3 may be more common in ESRD patients than previously described, and together with decreased T3 it may serve as an indicator of poor prognosis i... | yes |
converted_3146 | Is L-4F an apoE mimetic peptide? | Apolipoprotein A-I mimetic peptide 4F suppresses tumor-associated macrophages and pancreatic cancer progression., L-4F, an Apolipoprotein A-I (ApoA-I) mimetic peptide, is engineered to mimic the anti-inflammatory and anti-oxidative functionalities of ApoA-I. | no |
converted_3074 | Has strimvelis been approved by the European Medicines Agency? | Strimvelis (autologous CD34+ cells transduced to express adenosine deaminase [ADA]) is the first ex vivo stem cell gene therapy approved by the European Medicines Agency (EMA), indicated as a single treatment for patients with ADA-severe combined immunodeficiency (ADA-SCID) who lack a suitable matched related bone marr... | yes |
converted_1122 | Is there evidence for somatic mosaicism in Tuberous Sclerosis? | There are several case reports of solitary SEGA without any other manifestations of TSC. Usually these cases are thought to be forme fruste of TSC due to somatic mosaicism., Female germline mosaicism in tuberous sclerosis confirmed by molecular genetic analysis, This is the first case of germline mosaicism in tuberous ... | yes |
converted_3572 | Does the Mcm2-Ctf4-Polα axis play a role in transfer of histones to leading strand DNA at the replication forks? | The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands., Although essential for epigenetic inheritance, the transfer of parental histone (H3-H4)2 tetramers that contain epigenetic modifications to replicating DNA strands is poorly understood. Here, we show that the Mcm2-Ctf4-Polα axis fa... | no |
converted_3810 | Can AGY be used as antidiuretic replacement therapy? | AGY, a Novel Egg Yolk-Derived Anti-gliadin Antibody, Is Safe for Patients with Celiac Disease., Oral egg yolk anti-gliadin antibody (AGY) is a novel treatment to neutralize gluten and may improve the efficacy of the GFD., To determine the safety, tolerability, and potential efficacy of AGY in patients with CD., Most pa... | no |
converted_4017 | Is eptinezumab a small molecule? | Eptinezumab-jjmr (referred to as eptinezumab hereafter; Vyepti™) is a humanised monoclonal antibody that binds to calcitonin gene-related peptide (CGRP) and blocks its binding to the receptor. | no |
converted_2522 | Does Uc.160 promote cancer? | We previously discovered the downregulation of T-UCR expression in gastric cancer (GC), indicating that T-UCRs could play an important role in GC biology. Uc.160+, a T-UCR reported to be downregulated in human cancer, has not been examined in GC.METHODS: We analyzed the expression pattern of Uc.160+ in nonneoplastic an... | no |
converted_2270 | Are there ultraconserved genomic regions in the budding yeast? | Here, we present a systematic study of ultraconserved genomic regions in the budding yeast based on the publicly available genome sequences, in order to reveal their relationship with the adaptability or fitness advantages of the budding yeast.Results: Our results indicate that, in addition to some fundamental biologic... | yes |
converted_3187 | Do Crocus sativus extracts loosen the blood-brain barrier? | Crocus sativus Extract Tightens the Blood-Brain Barrier, Reduces Amyloid β Load and Related Toxicity in 5XFAD Mice., In vitro results showed that Crocus sativus extract increases the tightness of a cell-based blood-brain barrier (BBB) model and enhances transport of Aβ. Further in vivo studies confirmed the effect of C... | no |
converted_4296 | Is FKBP52 encoding a chaperone ? | Hsp90 co-chaperones Pp5 and FKBPs, The co-chaperone FK506-binding protein 51 (FKBP51), co‑chaperone FKBP52 | yes |
converted_4157 | Is metoprolol metabolized by CYP2D6? | Among these beta-blockers atenolol is mainly eliminated by renal excretion, bisoprolol is in part excreted as parent compound via the renal route (50%), the other 50% are hepatically metabolised, whereas metoprolol and carvedilol are metabolised by CYP2D6. | yes |
converted_3048 | Can pazopanib be used for treatment von Hippel-Lindau disease? | Variable response of CNS hemangioblastomas to Pazopanib in a single patient with von Hippel-Lindau disease: Case report., Treatment of RCCs with tyrosine kinase inhibitors (TKIs) such as Pazopanib is now first line therapy, but their effect on VHL-associated CNS HBs remains unknown. We report the use of Pazopanib in a ... | yes |
converted_926 | Is there a role for transcription factories in genome organization? | The mammalian nucleus is a highly complex structure that carries out a diverse range of functions such as DNA replication, cell division, RNA processing, and nuclear export/import. Many of these activities occur at discrete subcompartments that intersect with specific regions of the genome. Over the past few decades, e... | yes |
converted_292 | Is RET the major gene involved in Hirschsprung disease? | The RET proto-oncogene is the major gene associated to HSCR with differential contributions of its rare and common, coding and noncoding mutations to the multifactorial nature of this pathology, The RET proto-oncogene is the major gene for HSCR with differential contributions of its rare and common, coding and noncodin... | yes |
converted_4242 | Are G-quadruplexes(G4) possible drug targets for glioblastoma? | These observations indicate that 6OTD targets GSCs through G4 stabilization and promotion of DNA damage responses. Therefore, G4s are promising therapeutic targets for glioblastoma., Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole., G-quadruplex (G4) DNA is a type of ... | yes |
converted_4148 | Is the glucocorticoid receptor a transcription factor? | GR and KLF4, both pioneer transcription factors,, The glucocorticoid receptor (GR) is a ligand-binding dependent transcription factor that ultimately regulates vital biological processes and inflammation response through specific gene expression control, thus representing a notable drug target to explore. , The glucoco... | yes |
converted_1937 | Does NADPH oxidase 5 require any subunit for function? | Nox5 forms a functional oligomer mediated by self-association of its dehydrogenase domain., While Nox1-4 require regulatory subunits, including p22phox, Nox5 activity does not depend on any subunits. , Thus, Nox5 forms a catalytically active oligomer in the membrane that is mediated by its dehydrogenase domain. , Coe... | no |
converted_4031 | Was golimumab tested for diabetes? | CONCLUSIONS: Among children and young adults with newly diagnosed overt type 1 diabetes, golimumab resulted in better endogenous insulin production and less exogenous insulin use than placebo. , Golimumab and Beta-Cell Function in Youth with New-Onset Type 1 Diabetes., lticenter, placebo-controlled, double-blind, paral... | yes |
converted_364 | Is alemtuzumab effective for remission induction in patients diagnosed with T-cell prolymphocytic leukemia? | Sequential chemoimmunotherapy of fludarabine, mitoxantrone, and cyclophosphamide induction followed by alemtuzumab consolidation is effective in T-cell prolymphocytic leukemia, A central need in this historically refractory tumor is the controlled evaluation of multiagent chemotherapy and its combination with the curre... | yes |
converted_2379 | Are loop domains preserved upon cohesin loss? | Cohesin Loss Eliminates All Loop Domains., The human genome folds to create thousands of intervals, called "contact domains," that exhibit enhanced contact frequency within themselves. "Loop domains" form because of tethering between two loci-almost always bound by CTCF and cohesin-lying on the same chromosome. "Compar... | no |
converted_1434 | Does MVIIA and MVIIC bind to the same calcium channel? | We examined the post-pubertal behavioral effects of neonatal (postnatal day 7) medial prefrontal cortex infusion of either vehicle or N-type and P/Q-type presynaptic voltage-dependent calcium channel blockers (omega-conotoxins MVIIA and MVIIC respectively; 6.8 and 45 pmol infused respectively) in rat pups., Additionall... | no |
converted_1995 | Are there canonical marks of active chromatin in developmentally regulated genes? | Absence of canonical marks of active chromatin in developmentally regulated genes., The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally regulated d... | no |
converted_2868 | Is pazopanib an effective treatment of glioblastoma? | RESULTS: The six-month progression-free survival (PFS) rates in phase II (n = 41) were 0% and 15% in the PTEN/EGFRvIII-positive and PTEN/EGFRvIII-negative cohorts, respectively, leading to early termination. , Single-agent pazopanib did not prolong PFS in this patient population but showed in situ biological activity a... | no |
converted_2664 | Is recursive splicing more common in short introns? | Recent work in human and fruitfly tissues revealed that long introns are extensively processed cotranscriptionally and in a stepwise manner, before their two flanking exons are spliced together, Cutting a Long Intron Short: Recursive Splicing and Its Implications., Furthermore, we uncover the potential to investigate ... | no |
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