abstract string | rna_related int64 |
|---|---|
background berberine is a natural alkaloid derived from a traditional chinese herbal medicine. it is known to modulate microrna (mirna) levels, although the mechanism for this action is unknown. here, we previously demonstrate that the expression of 87 mirnas is differentially affected by berberine in multiple myeloma ... | 1 |
mammalian micrornas (mirnas) pair to 3'utrs of mrnas to direct their posttranscriptional repression. important for target recognition are approximately 7 nt sites that match the seed region of the mirna. however, these seed matches are not always sufficient for repression, indicating that other characteristics help spe... | 1 |
microrna (mirna) has been proved to play a key role in lipid metabolism. in our previous study, mir-125b was validated to be differentially expressed in preadipocytes and adipocytes, which was also proved to involve in lipid metabolism. to explore the comprehensive targets of mir-125b in adipocytes, isobaric tag for re... | 1 |
the gene encoding the mir-34a microrna is a transcriptional target of the p53 tumor suppressor protein and subject to epigenetic inactivation in colorectal cancer and numerous other tumor types. here, we combined pulsed silac (psilac) and microarray analyses to identify mir-34a-induced changes in protein and mrna expre... | 1 |
the structure and dynamics of the polyadenylation inhibition element (pie) rna, free and bound to the u1a protein, have been examined using time-resolved fret and 2-aminopurine (2ap) fluorescence. this regulatory rna, located at the 3' end of the u1a pre-mrna, adopts a u-shaped structure, with binding sites for a singl... | 1 |
we previously reported that mir-1 is among the most consistently down-regulated mirs in primary human prostate tumors. in this follow-up study, we further corroborated this finding in an independent data set and made the novel observation that mir-1 expression is further reduced in distant metastasis and is a candidate... | 1 |
background wnt-signalling has an important role in renal cancer and it is modulated by genistein in other cancers. recently, micrornas (mirnas) have emerged as new regulators of gene expression. thus, we focused on mirnas to examine the regulatory mechanism of genistein on the wnt-signalling pathway in renal cell carci... | 1 |
background microrna 21 (mir-21) has been demonstrated to be significantly elevated in many types of cancers, including the hepatocellular carcinoma (hcc). in the present study, we investigated the role of mir-21 in hcc by identifying its novel targets, as well as its underlying molecular mechanism. methods the expressi... | 1 |
the aim of this study was to investigate the role of microrna-21 (mir-21) in the regulation of phosphatase and tensin homolog deleted from chromosome-10 (pten) expression and proliferation of endometrioid endometrial cancer (eec) cells. we performed a qrt-pcr assay with mir-21 and pten in 16 paired eec tumor tissues an... | 1 |
micrornas (mirnas) are short noncoding regulatory rna molecules that modulate protein expression by inhibiting mrna translation or promoting mrna degradation. however, little is understood about the roles of mirnas in alzheimer's disease. during a research for mirnas that are differentially expressed in cerebral cortex... | 1 |
microrna-145 (mir-145) expression is downregulated in several human cancers, but its clinical and functional relevance to ovarian carcinoma has not yet been elucidated. this study addressed the hypothesis that mir-145 serves as a prognostic biomarker and a tumor suppressor that regulates the expression of high-mobility... | 1 |
previously, aimp3 (aminoacyl-trnasynthetase-interacting multifunctional protein-3) was shown to be involved in the macromolecular trna synthetase complex or to act as a tumor suppressor. in this study, we report a novel role of aimp3/p18 in the cellular aging of human mesenchymal stem cells (hmscs). we found that aimp3... | 1 |
micrornas are important regulators of gene expression, yet the functional outputs of most microrna-target interactions remain elusive. here we introduce the drosophila melanogaster microrna sponge (mir-sp) as a powerful transgenic technology to dissect the function of every microrna with precise spatiotemporal resoluti... | 1 |
the male-specific lethal (msl) complex regulates dosage compensation of the male x chromosome in drosophila. here, we report the crystal structure of its msl1/msl2 core, where two msl2 subunits bind to a dimer formed by two molecules of msl1. analysis of structure-based mutants revealed that msl2 can only interact with... | 1 |
micrornas (mirnas) are small regulatory rnas that are between 21 and 25 nucleotides in length and repress gene function through interactions with target mrnas. the genomes of metazoans encode on the order of several hundred mirnas, but the processes they regulate have been defined for only two in c. elegans. we searche... | 1 |
bacterial ribonuclease iii (rnase iii) is a highly conserved endonuclease, which plays pivotal roles in rna maturation and decay pathways by cleaving double-stranded structure of rnas. here we cloned rncs gene from the genomic dna of brucella melitensis, and analyzed the cleavage properties of rnase iii from brucella. ... | 1 |
purpose the purpose of this study was to investigate the clinicopathologic significance and potential role of mir-200b and mir-200c in the development and progression of gastric cancer. experimental design we examined mir-200b and mir-200c expression in 36 paired normal and stomach tumor specimens, as well as gastric c... | 1 |
microrna (mirna)-133b has been revealed to be downregulated in head and neck/oral, bladder, human non-small cell lung, colorectal and esophageal squamous cell cancer. the present study examined the expression of mir-133b in renal cell carcinoma (rcc) cell lines and the effects of mirna-133b on rcc cell proliferation, m... | 1 |
aberrant overexpression of the mir-17-92 polycistron is strongly associated with b-cell lymphomagenesis. recent studies have shown that mir-17-92 down-regulates the proapoptotic protein bim, leading to overexpression of bcl2, which likely plays a key role in lymphomagenesis. however, the fact that jeko-1 cells derived ... | 1 |
small noncoding rna (srna) molecules are integral components of the regulatory machinery for many bacterial species and are known to posttranscriptionally regulate metabolic and stress-response pathways, quorum sensing, virulence factors, and more. the yop-ysc type iii secretion system (t3ss) is a critical virulence co... | 1 |
small nucleolar rnas (snornas) are an abundant group of noncoding rnas mainly involved in the post-transcriptional modifications of rrnas in eukaryotes. in this study, a large-scale genome-wide analysis of the two major families of snorna genes in the fruit fly drosophila melanogaster has been performed using experimen... | 1 |
menin, the product of the men1 gene, functions as a tumor suppressor and was first identified in 1997 due to its causative role in the endocrine tumor disorder multiple endocrine neoplasia, type 1 (men1). more recently, menin has been identified as a key player in pancreatic islet biology with the observation of an inv... | 1 |
micrornas (mirnas) can influence lineage choice or affect critical developmental checkpoints during hematopoiesis. we examined the role of the p53-induced microrna mir-34a in hematopoiesis by gain-of-function analysis in murine bone marrow. constitutive expression of mir-34a led to a block in b cell development at the ... | 1 |
some micrornas (mirnas) have been implicated in hepatocellular carcinoma (hcc) development and progression. however, the roles and mechanisms of several mirnas in hcc remain poorly understood. here, we report that mir-379-5p, which is down-regulated in hcc tissues and cell lines, is associated with advanced tnm stage a... | 1 |
adenosine to inosine (a-to-i) pre-mrna editing by the adar enzyme family has the potential to increase the variety of the proteome. this editing by adenosine deamination is essential in mammals for a functional brain. to detect novel substrates for a-to-i editing we have used an experimental method to find selectively ... | 1 |
in many adult stem cell lineages, the continuous production of functional differentiated cells depends on the maintenance of progenitor cells in an undifferentiated and proliferative state, as well as the subsequent commitment to proper terminal differentiation. in the drosophila male germline stem cell (gsc) lineage, ... | 1 |
uncontrolled fibrosis in multiple organs is the main cause of death in systemic sclerosis (ssc), and transforming growth factor-β (tgf-β) activation plays a fundamental role in the process. our previous study demonstrated that mir-21 was significantly up-regulated in ssc fibroblasts. here, we found that tgf-β regulated... | 1 |
background colorectal carcinoma (crc) is a major cause of cancer mortality. the aberrant expression of several micrornas is associated with crc progression; however, the molecular mechanisms underlying this phenomenon are unclear. methods mir-638 and sry-box 2 (sox2) expression levels were detected in 36 tumor samples ... | 1 |
background neurotrophins and their receptors are key molecules in the regulation of neuronal differentiation and survival. they mediate the survival of neurons during development and adulthood and are implicated in synaptic plasticity. the human neurotrophin-3 receptor gene ntrk3 yields two major isoforms, a full-lengt... | 1 |
cellular senescence of normal human cells has by now far exceeded its initial role as a model system for aging research. many reports show the accumulation of senescent cells in vivo, their effect on their microenvironment and its double-edged role as tumour suppressor and promoter. importantly, removal of senescent ce... | 1 |
hypoxia-inducible factor 1 (hif-1) is a crucial transcription factor for the cellular adaptive response to hypoxia, which contributes to multiple events in cancer biology. micrornas (mirnas) are involved in almost all cellular activities such as differentiation, proliferation, and apoptosis. in this work, we use mirna ... | 1 |
epstein-barr virus (ebv) is a tumorigenic human γ-herpesvirus, which produces several known structured rnas with functional importance: two are implicated in latency maintenance and tumorigenic phenotypes, eber1 and eber2; a viral small nucleolar rna (v-snorna1) that may generate a small regulatory rna; and an internal... | 1 |
homeostasis of the intestine is maintained by dynamic regulation of a pool of intestinal stem cells. the balance between stem cell self-renewal and differentiation is regulated by the notch and insulin signaling pathways. dependence on the insulin pathway places the stem cell pool under nutritional control, allowing gu... | 1 |
neural progenitors self-renew and generate neurons throughout the central nervous system. here, we uncover an unexpected regional specificity in the properties of neural progenitor cells, revealed by the function of a microrna--mir-9. mir-9 is expressed in neural progenitors, and its knockdown results in an inhibition ... | 1 |
background vascular hyperproliferative disorders are characterized by excessive smooth muscle cell (smc) proliferation leading to vessel remodeling and occlusion. in pulmonary arterial hypertension (pah), smc phenotype switching from a terminally differentiated contractile to synthetic state is gaining traction as our ... | 1 |
genetic and functional data indicate that variation in the expression of the neurotrophin-3 receptor gene (ntrk3) may have an impact on neuronal plasticity, suggesting a role for ntrk3 in the pathophysiology of anxiety disorders. microrna (mirna) posttranscriptional gene regulators act by base-pairing to specific seque... | 1 |
alzheimer's disease (ad) is the most common form of dementia worldwide, characterized by progressive memory impairment, behavioral changes, and, ultimately, loss of consciousness and death. recently, microrna (mirna) dysfunction has been associated with increased production and impaired clearance of amyloid-β (aβ) pept... | 1 |
micrornas (mirnas) are endogenous noncoding rnas, about 22 nucleotides in length, that mediate post-transcriptional gene silencing by annealing to inexactly complementary sequences in the 3'-untranslated regions of target mrnas. our current understanding of the functions of mirnas relies mainly on their tissue-specific... | 1 |
rationale micrornas (mirnas), in particular mir-29b and mir-30c, have been implicated as important regulators of cardiac fibrosis. objective to perform a proteomics comparison of mirna effects on extracellular matrix secretion by cardiac fibroblasts. methods and results mouse cardiac fibroblasts were transfected with p... | 1 |
micrornas are important regulators of the pathogenesis of b-cell acute lymphoblastic leukaemia (b-all). in this study, we identified mir-3173 and its predicted target gene ptk2 were correspondingly differentially expressed in b-all patients. in b-all cell lines, cck-8 proliferation assay revealed that mir-3173 could in... | 1 |
myasthenia gravis (mg) is a t cell-dependent and b cell-mediated autoimmune disease of neuromuscular junctions and cytokines may play a crucial role in the pathogenesis and perpetuation of mg. micrornas (mirnas) have been implicated as fine-tuning regulators controlling diverse biological processes at the level of post... | 1 |
micrornas (mirna) are small rna molecules of approximately 20 to 22 nucleotides that reduce expression of proteins through mrna degradation and/or translational silencing. each known mirna has a large number of predicted targets. members of the let-7/mir-98 family of mirnas are up-regulated at the end of embryonic deve... | 1 |
mammalian genomes include many maternally and paternally imprinted genes. most of these are also expressed in the brain, and several have been implicated in regulating specific behavioral traits. here, we have used a knockout approach to study the function of peg13 , a gene that codes for a fast-evolving lncrna (long n... | 1 |
this study was designed to evaluate the effects of strontium on the expression levels of micrornas (mirnas) and to explore their effects on skeletal cell proliferation, differentiation, adhesion, and apoptosis. the targets of these mirnas were also studied. molecular cloning, cell proliferation assay, cell apoptosis as... | 1 |
transforming growth factor-β (tgfβ) promotes glomerular hypertrophy and matrix expansion, leading to glomerulosclerosis. micrornas are well suited to promote fibrosis because they can repress gene expression, which negatively regulate the fibrotic process. recent cellular and animal studies have revealed enhanced expre... | 1 |
genome-encoded micrornas (mirnas) provide a post-transcriptional regulatory layer that is important for pancreas development. however, how specific mirnas are intertwined into the transcriptional network, which controls endocrine differentiation, is not well understood. here, we show that microrna-7 (mir-7) is specific... | 1 |
while the immunological dysfunction in combat veterans with post-traumatic stress disorder (ptsd) has been well documented, the precise mechanisms remain unclear. the current study evaluated the role of microrna (mir) in immunological dysfunction associated with ptsd. the presence of peripheral blood mononuclear cells ... | 1 |
here, we show that mir-515-5p inhibits cancer cell migration and metastasis. rna-seq analyses of both oestrogen receptor receptor-positive and receptor-negative breast cancer cells overexpressing mir-515-5p reveal down-regulation of nras, fzd4, cdc42bpa, pik3c2b and mark4 mrnas. we demonstrate that mir-515-5p inhibits ... | 1 |
thermo-chemotherapy has been proven to reduce the invasion capability of cancer cells. however, the molecular mechanism underlying this anti-invasion effect is still unclear. in this study, the role of thermo-chemotherapy in the inhibition of tumor invasion was studied. the results demonstrated that expression of mir-2... | 1 |
to investigate whether the effect of maternal dietary protein on offspring lipid metabolism is mediated by microrna (mirna), fourteen meishan sows were fed either low-protein (lp, half of standard protein (sp) level, n 7) or sp (n 7) diets throughout gestation and lactation periods. ppar-γ and ccaat/enhancer-binding pr... | 1 |
the discovery that micrornas (mirnas) play important roles in regulating gene expression via posttranscriptional repression has revealed a previously unsuspected mechanism controlling development and progenitor-cell function (reviewed in ); however, little is known of mirna functions in mammalian organogenesis. process... | 1 |
the dpp and fat-hippo signaling pathways both regulate growth in drosophila. dpp is a bmp family ligand and acts via a smad family dna-binding transcription factor, mad. fat-hippo signaling acts via a non-dna-binding transcriptional coactivator protein, yorkie. here, we show that these pathways are directly interlinked... | 1 |
to define a complete catalog of the genes that are activated during mouse sclerotome formation, we sequenced rna from embryonic mouse tissue directed to form sclerotome in culture. in addition to well-known early markers of sclerotome, such as pax1, pax9, and the bapx2/nkx3-2 homolog nkx3-1, the long-noncoding rna peat... | 1 |
a new paradigm of gene expression regulation has emerged recently with the discovery of micrornas (mirnas). most, if not all, mirnas are thought to control gene expression, mostly by base pairing with mirna-recognition elements (mres) found in their messenger rna (mrna) targets. although a large number of human mirnas ... | 1 |
background the acvr1/alk-2 gene, encoding a bmp type i receptor, is mutated in fibrodysplasia ossificans progressiva, a severe form of heterotopic ossification. regulation of acvr1/alk-2 expression, still poorly understood, is likely to be controlled by transcriptional and post-transcriptional mechanisms. in our work, ... | 1 |
background micrornas play important roles in various biological processes involving fairly complex mechanism. analysis of genome-wide mirna microarray demonstrate that a single mirna can regulate hundreds of genes, but the regulative extent on most individual genes is surprisingly mild so that it is difficult to unders... | 1 |
objective it has been reported that microrna-195 (mir-195) protects against chronic brain injury induced by chronic brain hypoperfusion. however, neither the expression profile of mir-195 nor its potential role during acute ischemic stroke has been investigated. in this study, the authors' aim was to verify the mechani... | 1 |
the virulence gene icsa of shigella flexneri encodes an invasion protein crucial for host colonization by pathogenic bacteria. within the intergenic region vira-icsa, we have discovered a new gene that encodes a non-translated antisense rna (named rnag), transcribed in cis on the complementary strand of icsa. in vitro ... | 1 |
micrornas have been implicated in regulating diverse cellular pathways. although there is emerging evidence that some micrornas can function as oncogenes or tumour suppressors, the role of micrornas in mediating cancer metastasis remains unexplored. here we show, using a combination of mouse and human cells, that micro... | 1 |
reverse transcription of hepatitis b virus (hbv) pregenomic rna is essential for virus replication. in the first step of this process, hbv reverse transcriptase binds to the highly conserved encapsidation signal, epsilon (epsilon), situated near the 5' end of the pregenome. epsilon has been predicted to form a bulged s... | 1 |
eukaryotic translation initiation factor 2 (eif2) is a g-protein that functions as a central switch in the initiation of protein synthesis. in its gtp-bound state it delivers the methionyl initiator trna (met-trna(i)) to the small ribosomal subunit and releases it upon gtp hydrolysis following the recognition of the in... | 1 |
the selection of sites for pseudouridylation in eukaryotic cytoplasmic rrna occurs by the base pairing of the rrna with specific guide sequences within the rna components of box h/aca small nucleolar ribonucleoproteins (snornps). forty-four of the 46 pseudouridines (psis) in the cytoplasmic rrna of saccharomyces cerevi... | 1 |
pten is a tumor-suppressor gene that has been shown to be under the regulatory control of a pten pseudogene expressed noncoding rna, ptenpg1. here, we characterize a previously unidentified ptenpg1-encoded antisense rna (asrna), which regulates pten transcription and pten mrna stability. we find two ptenpg1 asrna isofo... | 1 |
insect development and metamorphosis are regulated by the coordination of ecdysone and juvenile hormones. insect micrornas (mirnas) also act in insect development and metamorphosis by regulating genes in the ecdysone cascade. although hundreds of insect mirnas have been identified, the physiological functions of most r... | 1 |
background micrornas (mirnas) regulate a lot of physiological and pathological processes, including myocardial ischemia/reperfusion. recent studies reported that knockdown of mir-92a could attenuate ischemia/reperfusion-induced myocardial injury. in the present study, we examined the potential anti-apoptotic effects of... | 1 |
angiogenesis is important in pathophysiological processes, including the pathogenesis of acute monocytic leukemia (aml). microrna‑21 (mir‑21) is overexpressed and exhibits oncogenic activity in cancer. however, the biological mechanism underlying the effect of mir‑21 in aml remains to be fully elucidated. in the presen... | 1 |
mirna cluster mir-17-92 is known as oncomir-1 due to its potent oncogenic function. mir-17-92 is a polycistronic cluster that encodes 6 mirnas, and can both facilitate and inhibit cell proliferation. known targets of mirnas encoded by this cluster are largely regulators of cell cycle progression and apoptosis. here, we... | 1 |
objective the purpose of this study was to investigate the role of mir-130b in the development of multidrug-resistant ovarian cancer. methods the expression of mir-130b was assessed in ovarian tissues and cell lines by qrt-pcr. in vitro, mir-130b level was manipulated by transfection with mimics or inhibitors. methylat... | 1 |
background esophageal squamous cell carcinoma (escc) is the major histological type of esophageal cancer in developing countries. the prognosis and survival rate of escc are very poor. recently, micrornas (mirnas) have emerged as important regulators of cancer cell biological processes. to better understanding the mole... | 1 |
the covr/s two-component system regulates the transcription of many genes that are crucial for the virulence of streptococcus pyogenes (group a streptococcus, gas). previously, we demonstrated that one gene repressed directly by covr is rivr, which encodes a member of the rofa-like family of transcriptional regulators.... | 1 |
cardiovascular disease has been the biggest killer in the united states for decades, with almost a million new cases each year. even though mammalian rodent neonatal cardiomyocytes show proliferative potential for up to 5 days, adult cardiomyocytes lose this ability. insufficient cardiomyocyte proliferation is one of t... | 1 |
bombyx mori cytoplasmic polyhedrosis virus (bmcpv) is a major viral pathogen of silkworm and remains a big challenge to the sericultural industry. insulin-related peptide binding protein 2 (ibp2) gene, induced by bmcpv infection may play an important role in b. mori immune response. micrornas (mirnas) are small noncodi... | 1 |
neuronal gene expression is tightly regulated in developing cns. here, we demonstrate the anti-neural function of phosphatase scp1 (small c-terminal domain phosphatase 1) during development. we further show that the neuron-enriched microrna mir-124 directly targets scp1-3' untranslated region (utr) to suppress scp1 exp... | 1 |
deregulated proliferation is a hallmark of cancer cells. here, we show that microrna-10b* is a master regulator of breast cancer cell proliferation and is downregulated in tumoural samples versus matched peritumoural counterparts. two canonical cpg islands (5 kb) upstream from the precursor sequence are hypermethylated... | 1 |
background the genus alphavirus includes several potentially lethal human viruses. additionally, species such as sindbis virus and semliki forest virus are important vectors for gene therapy, vaccination and cancer research, and important models for virion assembly and structural analyses. the genome encodes nine known... | 1 |
micrornas (mirnas) have been implicated in regulating various aspects of animal development, but their functions in neurogenesis are largely unknown. here we report that loss of mir-9a function in the drosophila peripheral nervous system leads to ectopic production of sensory organ precursors (sops), whereas overexpres... | 1 |
epithelial-mesenchymal interaction has critical roles for organ development including teeth, during which epithelial thickening and mesenchymal condensation are initiated by precise regulation of the signaling pathway. in teeth, neural crest-derived mesenchymal cells expressed pdgf receptors migrate and become condense... | 1 |
background micrornas are small non-coding rnas that regulate post-transcriptional mrna expression by binding to 3' untranslated region (3'-utr) of the complementary mrna sequence resulting in translational repression and gene silencing. they act as negative regulators of gene expression and play a pivotal role in regul... | 1 |
unlabelled growing evidence indicates that deregulation of micrornas (mirnas) contributes to tumorigenesis. down-regulation of mir-195 has been observed in various types of cancers. however, the biological function of mir-195 is still largely unknown. in this study we aimed to elucidate the pathophysiologic role of mir... | 1 |
the aberrant expression of micrornas is associated with development and progression of cancers. down-regulation of mir-124 has been demonstrated in the hepatocellular carcinoma (hcc), but the underlying mechanism by which mir-124 suppresses tumorigenesis in hcc remains elusive. in this study, we found that mir-124 supp... | 1 |
micrornas (mirnas) are highly expressed in vertebrate neural tissues, but the contribution of specific mirnas to the development and function of different neuronal populations is still largely unknown. we report that mirnas are required for terminal differentiation of olfactory precursors in both mouse and zebrafish bu... | 1 |
rna binding proteins and messenger rnas (mrnas) assemble into ribonucleoprotein granules that regulate mrna trafficking, local translation, and turnover. the dysregulation of rna-protein condensation disturbs synaptic plasticity and neuron survival and has been widely associated with human neurological disease. neurona... | 1 |
the variable clinical course in chronic lymphocytic leukaemia (cll) largely depends on p53 functionality and b-cell receptor (bcr) signalling propensity; however, it is unclear if there is any crosstalk between these pathways. we show that dna damage response (ddr) activation leads to down-modulating the transcriptiona... | 1 |
objective micrornas (mirs) regulate angiogenesis by posttranscriptional silencing of target genes. the significance of angiostatic mir-200b in switching on skin wound angiogenesis was tested. methods and results wounding caused imminent and transient downregulation of mir-200b in dermal wound-edge endothelial cells. de... | 1 |
the european large subunit ribosomal rna database compiles all complete or nearly complete large subunit ribosomal rna sequences available from public sequence databases. these are provided in aligned format and the secondary structure, as derived by comparative sequence analysis, is included. additional information ab... | 1 |
the aim of the present study was to measure the expression of microrna (mir)-146a in liver tissues, peripheral blood mononuclear cells (pmbc) and serum from patients with hepatitis b and either liver fibrosis or cirrhosis, as well as to determine the regulatory mechanism of mir-146a. a total of 36 patients with hepatit... | 1 |
glioblastoma is the most common and lethal primary brain tumor. tumor initiation and recurrence are likely caused by a sub-population of glioblastoma stem cells, which may derive from mutated neural stem and precursor cells. since cd133 is a stem cell marker for both normal brain and glioblastoma, and to better underst... | 1 |
in many mouse models of skin cancer, only a few tumors typically form even though many cells competent for tumorigenesis receive the same oncogenic stimuli. these observations suggest an active selection process for tumor-initiating cells. here, we use quantitative mrna- and mir-seq to determine the impact of hras(g12v... | 1 |
seven complete and two partial copies of is1221 variants from mycoplasma hyorhinis and mycoplasma hyopneumoniae characterized to date have established a consensus is1221 as a 1513 bp element with unique structural characteristics resembling the is3 family of bacterial insertion sequences. each is1221 copy contains high... | 1 |
the physiological role of escherichia coli spot 42 rna has remained obscure, even though the 109-nucleotide rna was discovered almost three decades ago. structural features of spot 42 rna and previous work suggested to us that the rna might be a regulator of discoordinate gene expression of the galactose operon, a cont... | 1 |
background in our previous paper, we demonstrated that connexin 43 (cx43) was highly expressed in bladder cancer (bc) tissues. but the molecular mechanism about micrornas (mirnas) regulation upstream of cx43 in bc has not been well elucidated and remains to be further studied. microrna-139-5p (mir-139-5p) is a tumor su... | 1 |
the genomic rna of human astrovirus was sequenced and found to contain 6797 nt organized into three open reading frames (1a, 1b, and 2). a potential ribosomal frameshift site identified in the overlap region of open reading frames 1a and 1b consists of a "shifty" heptanucleotide and an rna stem-loop structure that clos... | 1 |
currently, multiple myeloma (mm) patients are broadly grouped into a non-hyperdiploid (nh-mm) group, highly enriched for igh translocations, or into a hyperdiploid (h-mm) group, which is typically characterized by trisomies of some odd-numbered chromosomes. we compared the micro rna (mirna) expression profiles of these... | 1 |
we screened for new structural non-coding rnas (ncrnas) in the genome sequence of the yeast saccharomyces cerevisiae using computational comparative analysis of genome sequences from five related species of saccharomyces. the screen identified 92 candidate ncrna genes. thirteen showed discrete transcripts when assayed ... | 1 |
objectives the present study aimed to explore the role of microribonucleic acid (mirna) let-7g in regulating endothelial functions. background derangement of mirnas is implicated in the pathogenesis of cardiovascular diseases. because the transforming growth factor (tgf)-β pathway plays a regulatory role in endothelial... | 1 |
microrna-122, an abundant and conserved liver-specific mirna, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of the mir-122 target network remains incomplete. to this end, we performed argonaute crosslinking immunoprecipitation (argonaute -clip) seque... | 1 |
micrornas (mirnas) are non-coding rnas regulating gene expression post-transcriptionally. we have characterized the role of mirnas in regulating the human epidermal growth factor receptor 2 (her2)-pathway in breast cancer. we performed mirna gain-of-function assays by screening two her2 amplified cell lines (kpl-4 and ... | 1 |
the large nucleus limited noncoding hsromega-n rna of drosophila melanogaster is known to associate with a variety of heterogeneous nuclear rna-binding proteins (hnrnps) and certain other rna-binding proteins to assemble the nucleoplasmic omega speckles. in this article, we show that rnai-mediated depletion of this non... | 1 |
in recent years, a number of small rna molecules derived from snornas have been observed. findings concerning the functions of snorna-derived small rnas (sdrnas) in cells are limited primarily to their involvement in microrna pathways. however, similar molecules have been observed in saccharomyces cerevisiae, which is ... | 1 |
telomerase is a specialized reverse transcriptase containing an intrinsic telomerase rna (tr) which provides the template for telomeric dna synthesis. distinct from conventional reverse transcriptases, telomerase has evolved a unique tr-binding domain (trbd) in the catalytic telomerase reverse transcriptase (tert) prot... | 1 |
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