Dataset Preview
The full dataset viewer is not available (click to read why). Only showing a preview of the rows.
The dataset generation failed because of a cast error
Error code: DatasetGenerationCastError
Exception: DatasetGenerationCastError
Message: An error occurred while generating the dataset
All the data files must have the same columns, but at some point there are 7 new columns ({'_format_kwargs', '_format_type', '_data_files', '_format_columns', '_fingerprint', '_output_all_columns', '_split'}) and 2 missing columns ({'article', 'article_id'}).
This happened while the json dataset builder was generating data using
hf://datasets/RayDu0010/scifact_validation/scifact_validation/klora_validation/state.json (at revision 628685c93925395e2393eef1122d8519022105f6)
Please either edit the data files to have matching columns, or separate them into different configurations (see docs at https://hf.co/docs/hub/datasets-manual-configuration#multiple-configurations)
Traceback: Traceback (most recent call last):
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1871, in _prepare_split_single
writer.write_table(table)
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/arrow_writer.py", line 623, in write_table
pa_table = table_cast(pa_table, self._schema)
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/table.py", line 2293, in table_cast
return cast_table_to_schema(table, schema)
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/table.py", line 2241, in cast_table_to_schema
raise CastError(
datasets.table.CastError: Couldn't cast
_data_files: list<item: struct<filename: string>>
child 0, item: struct<filename: string>
child 0, filename: string
_fingerprint: string
_format_columns: null
_format_kwargs: struct<>
_format_type: null
_output_all_columns: bool
_split: null
to
{'article_id': Value(dtype='int64', id=None), 'article': Value(dtype='string', id=None)}
because column names don't match
During handling of the above exception, another exception occurred:
Traceback (most recent call last):
File "/src/services/worker/src/worker/job_runners/config/parquet_and_info.py", line 1438, in compute_config_parquet_and_info_response
parquet_operations = convert_to_parquet(builder)
File "/src/services/worker/src/worker/job_runners/config/parquet_and_info.py", line 1050, in convert_to_parquet
builder.download_and_prepare(
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 925, in download_and_prepare
self._download_and_prepare(
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1001, in _download_and_prepare
self._prepare_split(split_generator, **prepare_split_kwargs)
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1742, in _prepare_split
for job_id, done, content in self._prepare_split_single(
File "/src/services/worker/.venv/lib/python3.9/site-packages/datasets/builder.py", line 1873, in _prepare_split_single
raise DatasetGenerationCastError.from_cast_error(
datasets.exceptions.DatasetGenerationCastError: An error occurred while generating the dataset
All the data files must have the same columns, but at some point there are 7 new columns ({'_format_kwargs', '_format_type', '_data_files', '_format_columns', '_fingerprint', '_output_all_columns', '_split'}) and 2 missing columns ({'article', 'article_id'}).
This happened while the json dataset builder was generating data using
hf://datasets/RayDu0010/scifact_validation/scifact_validation/klora_validation/state.json (at revision 628685c93925395e2393eef1122d8519022105f6)
Please either edit the data files to have matching columns, or separate them into different configurations (see docs at https://hf.co/docs/hub/datasets-manual-configuration#multiple-configurations)Need help to make the dataset viewer work? Make sure to review how to configure the dataset viewer, and open a discussion for direct support.
article_id int64 | article string |
|---|---|
5,824,985 | BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity.Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large populations treated in routine clinical practice is lacking.The objective of this study was to measure the association b... |
6,540,064 | BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB).Although studies in mice and cells have identified increased hepatic LDL receptors as the basis for LDL lowering by PCSK9 inhibito... |
8,551,160 | Mitochondria are the primary energy-generating system in most eukaryotic cells.Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis.Given these well-established functions, it might be expected that mitochondrial dysfunction would give rise to a simple and predictable set of defect... |
2,078,658 | Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-renewal, pluripotency, and somatic cell reprogramming.However, limited information is available on Oct4-associated protein complexes and their intrinsic protein-protein interactions that dictate Oct4's critical regulatory activitie... |
30,507,607 | Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent cell identity.Whereas the genomic locations of several pluripotency transcription factors have been reported, the spectrum of their interaction partners is underexplored.Here, we use an improved affinity protocol to purify Oc... |
9,745,001 | OBJECTIVE To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre.
DESIGN Consecutive patients with multinodular non-toxic goitre selected for radioactive iodine treatment and followed for a minimum of 12 months (median 48 months) after an... |
6,710,713 | OBJECTIVE To determine whether there are risk factors in a doctor's time at medical school that are associated with subsequent professional misconduct.
DESIGN Matched case-control study.Setting Records from medical schools and the General Medical Council (GMC).
PARTICIPANTS 59 doctors who had graduated from any o... |
4,200,695 | OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder function and pain more than unspecific exercises in patients with subacromial impingement syndrome, thereby decreasing the need for arthroscopic subacromial decompression.
DESIGN Randomised, p... |
19,912,367 | Age-related changes in the niche have long been postulated to impair the function of somatic stem cells.Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduced levels of fibronectin (FN), leading to detrimental consequences for the function and maintenance of muscle stem cell... |
19,205,437 | Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear.Here we report a robust UCP1-independent thermogenic mechanism in beige fat that involves enhanced ATP-dependent Ca2+ cycling by sarco/endoplasmic reticulum Ca2+-ATPase 2b (SERCA2b... |
6,309,659 | CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women.A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized but not studied.
OBJECTIVE To determine whether a longer reproductive period, as an indicator of longer exposure to endogenou... |
12,810,152 | CONTEXT Hyperhomocysteinemia is caused by genetic and lifestyle influences, including low intakes of folate and vitamin B6.However, prospective data relating intake of these vitamins to risk of coronary heart disease (CHD) are not available.
OBJECTIVE To examine intakes of folate and vitamin B6 in relation to the in... |
3,355,397 | IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers.
OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers.
DESIGN, SETTING, AND PARTICIPANTS Cohort and nested case-control analyses among persons with diabetes.A bladder cancer ... |
21,239,672 | OBJECTIVE To assess the association between use of macrolide antibiotics in mothers and infants from pregnancy onset until 120 days after birth and infantile hypertrophic pyloric stenosis (IHPS).
DESIGN Nationwide register based cohort study.
SETTING Denmark, 1996-2011.
PARTICIPANTS 999,378 liveborn singletons... |
16,066,726 | Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells.Loss of TNF signaling causes progression of tuberculosis in humans, and the increased mortality of Mycobacterium tuberc... |
15,928,989 | Successful pregnancy requires coordination of an array of signals and factors from multiple tissues.One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis.It is strongly expressed in granulosa cells of ovarian follicles and in the corpus luteum ... |
15,319,019 | Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains.Almost all known RT inhibitor resistance mutations identified to date map to the polymerase domain of the enzyme.H... |
597,790 | Although mast cell functions have classically been related to allergic responses, recent studies indicate that these cells contribute to other common diseases such as multiple sclerosis, rheumatoid arthritis, atherosclerosis, aortic aneurysm and cancer.This study presents evidence that mast cells also contribute to die... |
34,071,621 | Vascular disease progression is associated with marked changes in vascular smooth muscle cell (SMC) phenotype and function.SMC contractile gene expression and, thus differentiation, is under direct transcriptional control by the transcription factor, serum response factor (SRF); however, the mechanisms dynamically regu... |
11,614,737 | IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence.
OBJECTIVE To determine efficacy and safety of varenicline and bupropion sustained-release (SR; combination therapy) compared with varenicline (monotherapy) in cigarette smokers.
DESIGN, SETTING, AND PARTICIPAN... |
12,584,053 | OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three years.
DESIGN Three year follow-up of a multicentre cluster randomised controlled trial in primary care, with randomisation at pract... |
13,513,790 | Haploid cells are amenable for genetic analysis.Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells.However, successful generation of live animals from these haESCs, which is needed to extend the genetic analysis to the org... |
2,177,022 | Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induce cell adhesion.Analyzing dendritic cell (DC) migration, we showed that these distinct cellular responses depended on the mode of chemokine presentation within tissues.The surface... |
10,984,005 | CONTEXT More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity disorder (ADHD).These agents can increase heart rate and blood pressure, raising concerns about their cardiovascular safety.
OBJECTIVE To examine whether current use of medications pr... |
11,705,328 | BACKGROUND Lowering serum homocysteine levels with folic acid is expected to reduce mortality from ischemic heart disease.Homocysteine reduction is known to be maximal at a folic acid dosage of 1 mg/d, but the effect of lower doses (relevant to food fortification) is unclear.
METHODS We randomized 151 patients with ... |
14,376,683 | The non-enveloped bacilliform viruses are the second group of plant viruses known to possess a genome consisting of circular double-stranded DNA.We have characterized the viral transcript and determined the complete sequence of the genome of Commelina mellow mottle virus (CoYMV), a member of this group.Analysis of the ... |
16,256,507 | CONTEXT Adequate vitamin D status for optimum bone health has received increased recognition in recent years; however, the ideal intake is not known.Serum 25-hydroxyvitamin D is the generally accepted indicator of vitamin D status, but no universal reference level has been reached.
OBJECTIVE To investigate the relat... |
5,172,048 | Exuberant fibroproliferation is a common complication after injury for reasons that are not well understood.One key component of wound repair that is often overlooked is mechanical force, which regulates cell-matrix interactions through intracellular focal adhesion components, including focal adhesion kinase (FAK).Here... |
28,369,117 | Axons and dendrites differ in both microtubule organization and in the organelles and proteins they contain.Here we show that the microtubule motor dynein has a crucial role in polarized transport and in controlling the orientation of axonal microtubules in Drosophila melanogaster dendritic arborization (da) neurons.Ch... |
5,323,845 | BACKGROUND Direct recordings from peripheral sympathetic nerves have shown an increased sympathetic drive in pregnancy-induced hypertension (PIH) and preeclampsia (PE).It is unknown whether sympathetic drive is altered in normal pregnancy, when arterial blood pressure can be normal or relatively low.The aim of this stu... |
18,997,216 | Muscle sympathetic nerve activity is increased during normotensive pregnancy while mean arterial pressure is maintained or reduced, suggesting baroreflex resetting.We hypothesized spontaneous sympathetic baroreflex gain would be reduced in normotensive pregnant women relative to nonpregnant matched controls.Integrated ... |
13,907,928 | Baseline neurovascular transduction is reduced in normotensive pregnancy; however, little is known about changes to neurovascular transduction during periods of heightened sympathetic activation.We tested the hypothesis that, despite an exacerbated muscle sympathetic nerve activity (microneurography) response to cold p... |
16,056,514 | Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks.In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic sodium lac... |
14,606,752 | OBJECTIVE To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headaches.
DESIGN Meta-analysis.
DATA SOURCES Medline, Embase, the Cochrane Trials Registry, and PsycLIT.Studies reviewed Randomised trials of adults receiving tricycl... |
20,033,112 | Recent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic cell types, but to date stem or progenitor cells have only been reprogrammed for the blood and neuronal lineages.We previously reported generation of induced hepatocyte-like (iHep) cells by transduction of Gata4, Hnf1α, and Fox... |
15,041,758 | OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of life.
DESIGN A randomised controlled trial of multi-condition collaborative care for depression and poorly controlled diabetes and/or risk factors for coronary heart... |
21,003,930 | BACKGROUND Long-term exposure to pollution can lead to an increase in the rate of decline of lung function, especially in older individuals and in those with chronic obstructive pulmonary disease (COPD), whereas shorter-term exposure at higher pollution levels has been implicated in causing excess deaths from ischaemic... |
5,956,380 | Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect.To determine the genetic and epigenetic landscape of these tumors, we performed exomic sequencing of 14 brainstem gliomas (BSGs) and 12 thalamic gliomas.We also performed targeted mutational analysis of an addit... |
4,414,547 | Improved sequencing technologies offer unprecedented opportunities for investigating the role of rare genetic variation in common disease.However, there are considerable challenges with respect to study design, data analysis and replication.Using pooled next-generation sequencing of 507 genes implicated in the repair o... |
5,531,479 | Neutrophils rapidly undergo polarization and directional movement to infiltrate the sites of infection and inflammation.Here, we show that an inhibitory MHC I receptor, Ly49Q, was crucial for the swift polarization of and tissue infiltration by neutrophils.During the steady state, Ly49Q inhibited neutrophil adhesion by... |
18,174,210 | BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb).Individuals homozygous for alpha(+)-thalassaemia have microcytosis and an increased erythrocyte count.Alpha(+)-thalassaemia homozygosity confers cons... |
4,883,040 | BACKGROUND Human immunodeficiency virus (HIV) infection is the strongest risk factor for developing tuberculosis and has fuelled its resurgence, especially in sub-Saharan Africa.In 2010, there were an estimated 1.1 million incident cases of tuberculosis among the 34 million people living with HIV worldwide.Antiretrovir... |
2,052,720 | OBJECTIVE To investigate the association between gastric cancer and prior infection with Helicobacter pylori.
DESIGN Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases.Presence of H pylori antibody (greater tha... |
13,794,374 | Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis.Although little is known about lipid droplet formation and regulation, it is clear that members of the PAT (perilipin, adipocyte differentiation related protein, tail interacting prote... |
13,764,090 | Both rectal and vaginal mucosal surfaces serve as transmission routes for pathogenic microorganisms.Vaccination through large intestinal mucosa, previously proven protective for both of these mucosal sites in animal studies, can be achieved successfully by direct intracolorectal (i.c.r.) administration, but this route ... |
6,796,297 | Osteogenesis during bone modeling and remodeling is coupled with angiogenesis.A recent study showed that a specific vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), couples angiogenesis and osteogenesis.Here, we found that platelet-derived growth factor-BB (PDGF-BB) secreted by preosteoclasts in... |
24,241,932 | OBJECTIVE To examine the effect of ethnicity on the relation between tuberculosis and deprivation.
DESIGN Retrospective ecological study comparing incidence of tuberculosis in white and south Asian residents of the 39 electoral wards in Birmingham with ethnic specific indices of deprivation.
SETTING Birmingham, 1... |
22,194,407 | This paper seeks to establish the strength of association between contemporary tuberculosis (TB) in England and Wales and several potential aetiological factors.It presents an ecological analysis of standardised annual TB mortality rates for the 403 local authority districts between 1982 and 1992, disaggregated by age ... |
13,900,610 | BACKGROUND Self-harm and suicide are common in prisoners, yet robust information on the full extent and characteristics of people at risk of self-harm is scant.Furthermore, understanding how frequently self-harm is followed by suicide, and in which prisoners this progression is most likely to happen, is important.We di... |
9,394,119 | IMPORTANCE Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists.
OBJECTIVE To identify mutation-specific cancer risks for carriers of BRCA1/2.
DESIGN, SETTING, AND PARTICIPANTS Observational study of women who were ascertained between 1937 and 20... |
19,688,024 | Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP).Other putative DNA receptors have been described, but whether their functions are redundant, tissue-specific or integrate... |
1,456,068 | BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premature death, little is known about the combined impact on mortality outcomes, in particular among Chinese ... |
7,209,559 | CONTEXT The incidence of distal forearm fractures in children peaks around the time of the pubertal growth spurt, possibly because physical activity increases at the time of a transient deficit in cortical bone mass due to the increased calcium demand during maximal skeletal growth.Changes in physical activity or diet ... |
22,405,338 | Kinetochores attach the replicated chromosomes to the mitotic spindle and orchestrate their transmission to the daughter cells.Kinetochore–spindle binding and chromosome segregation are mediated by the multi-copy KNL1Spc105, MIS12Mtw1 and NDC80Ndc80 complexes that form the so-called KMN network.KMN–spindle attachment i... |
4,709,641 | Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems.Using human neurons derived from induced pluripotent stem cells that expressed apolipoprotein E4 (ApoE4), a variant of the APOE gene pro... |
3,654,468 | Importance Glucagon-like peptide-1 (GLP-1) receptor agonists are effective therapies for the treatment of type 2 diabetes and are all currently available as an injection.Objectives To compare the effects of oral semaglutide with placebo (primary) and open-label subcutaneous semaglutide (secondary) on glycemic control i... |
19,736,671 | Human tumors show a high level of genetic heterogeneity, but the processes that influence the timing and route of metastatic dissemination of the subclones are unknown.Here we have used whole-exome sequencing of 103 matched benign, malignant and metastatic skin tumors from genetically heterogeneous mice to demonstrate ... |
10,546,779 | Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition.In this study, we report the derivation of a pluripotent embryonic stem (ES) cell line (SCNT-hES-1) from a cloned human blastocyst.The SCNT-hES-1 cells displayed typical ES cell morphology and ce... |
25,413,327 | Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture.Here we describe the clonal derivation of two human ES cell lines, H9.1 and H9.2.At the time of the clonal derivation of the H9.1 and H9.2 ES... |
36,651,210 | Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers.These cells have, therefore, potential for in vitro differentiation studies, gene function, and so on.The aim of thi... |
87,610,599 | Objective To explore the in vitro maintenance and characterization of human embryonic stem cells(hESCs).Methods hESCs were cultured on feeder layer with ES culture medium,which consists of 20% Knockout Serum Replacement,Knockout DMEM and 10 ng/mL bFGF.Undifferentiated status of hESCs was identified by cell morphology,a... |
37,549,932 | Resistance to apoptosis, often achieved by the overexpression of antiapoptotic proteins, is common and perhaps required in the genesis of cancer.However, it remains uncertain whether apoptotic defects are essential for tumor maintenance.To test this, we generated mice expressing a conditional BCL-2 gene and constitutiv... |
14,803,797 | Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO).We demonstrate here that metabolism by intestinal microbiota of dietary L-carnitine, a trimethylamine abundant in red meat, also prod... |
12,258,338 | CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug costs.However, whether pharmacist participation in the ICU at the time of drug prescribing reduces adverse events has not been studied.
OBJECTIVE To measure t... |
16,728,949 | The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism.Several recent studies indicate that FoxO-dependent signaling is required for long-term regenerative potential of t... |
21,414,718 | Trefoil factor family 1 (TFF1) is a member of the TFF-domain peptide family involved in epithelial restitution and cell motility.Recently, we screened Piezo1 as a candidate TFF1-binding protein.We aimed to confirm Piezo1 as a novel TFF1 binding protein and to assess the role of this interaction in mediating gastric can... |
44,048,701 | IMPORTANCE The need for surgery for the majority of patients with displaced proximal humeral fractures is unclear, but its use is increasing.
OBJECTIVE To evaluate the clinical effectiveness of surgical vs nonsurgical treatment for adults with displaced fractures of the proximal humerus involving the surgical neck. ... |
8,533,245 | The ER-associated degradation (ERAD) pathway serves as an important cellular safeguard by directing incorrectly folded and unassembled proteins from the ER to the proteasome.Still, however, little is known about the components mediating ERAD of membrane proteins.Here we show that the evolutionary conserved rhomboid fam... |
1,522,647 | BACKGROUND Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate immune system.However, mtDNA level has not been tested for its role as a biomarker in the intensive care unit (ICU).We hypothesized that circulating cell-free mtDNA levels would be associated with mortality and improve risk pred... |
26,064,662 | Importance Hemoglobin A1c (HbA1c) reflects past glucose concentrations, but this relationship may differ between those with sickle cell trait (SCT) and those without it.Objective To evaluate the association between SCT and HbA1c for given levels of fasting or 2-hour glucose levels among African Americans.Design, Settin... |
12,670,680 | In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality.We report that activation of basophils by autoreactive IgE causes their homing to lymph nodes, promoting T helper type 2 (T(H)2) cell differentiation and enhancin... |
20,333,864 | The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression.Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors.Progression to invasion wa... |
14,340,571 | Background Celiac disease is a small intestinal inflammatory disorder characterized by malabsorption, nutrient deficiency, and a range of clinical manifestations.It is caused by an inappropriate immune response to dietary gluten and is treated with a gluten-free diet.Recent feeding studies have indicated oats to be sa... |
17,587,795 | Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes.Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines.Here, we extensively survey diverse species lacking Dnmt1 and show that, surprisingly, symmetrical CG methylation is nonetheles... |
16,737,210 | CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant.Kidney paired donation (KPD) offers incompatible donor/recipient pairs the opportunity to match for compatible transplants.Despite its increasing popularity, very few trans... |
21,009,874 | CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear.
OBJECTIVE To assess whether immunosuppressive drugs increase mortality.
DESIGN Retrospective cohort study evaluating overall and cancer mortality in relation to immunosuppressive drug exposure among patients with ocular inflammator... |
11,902,109 | The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and differentiate into three types of mature cell--plasmatocytes, crystal cells and lamellocytes--the functions of which are reminiscent of mammalian myeloid cells... |
27,099,731 | IMPORTANCE There is currently no consensus for the screening and treatment of patent ductus arteriosus (PDA) in extremely preterm infants.Less pharmacological closure and more supportive management have been observed without evidence to support these changes.
OBJECTIVE To evaluate the association between early scree... |
3,475,317 | Granulomas are the pathological hallmark of tuberculosis (TB).However, their function and mechanisms of formation remain poorly understood.To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from subjects with tuberculosis in an unbiased manner.Using laser-capture microdissection, mass s... |
27,446,873 | OBJECTIVE To assess the performance and impact of primary human papillomavirus (HPV) DNA screening with cytology triage compared with conventional cytology on cervical cancer and severe pre-cancerous lesions.
DESIGN Randomised trial.
SETTING Population based screening programme for cervical cancer in southern Fin... |
27,873,158 | BACKGROUND Human papillomavirus (HPV) testing is known to be more sensitive, but less specific than cytology for detecting cervical intraepithelial neoplasia (CIN).We assessed the efficacy of cervical-cancer screening policies that are based on HPV testing.
METHODS Between March, 2004, and December, 2004, in two sep... |
28,617,573 | More than ever, clinicians need regularly updated reviews given the continuously increasing amount of new information regarding innovative cervical cancer prevention methods.A summary is given from recent meta-analyses and systematic reviews on 3 possible clinical applications of human papillomavirus (HPV) testing: tri... |
9,764,256 | BACKGROUND Human papillomavirus (HPV) testing is more sensitive for the detection of high-grade cervical lesions than is cytology, but detection of HPV by DNA screening in two screening rounds 5 years apart has not been assessed.The aim of this study was to assess whether HPV DNA testing in the first screen decreases d... |
46,695,481 | BACKGROUND Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade cervical epithelial neoplasia or cervica... |
13,910,150 | Blimp1 (Prdm1), the key determinant of primordial germ cells (PGCs), plays a combinatorial role with Prdm14 during PGC specification from postimplantation epiblast cells.They together initiate epigenetic reprogramming in early germ cells toward an underlying pluripotent state, which is equivalent to embryonic stem cell... |
24,922,825 | Traditionally, vaccine development involves tradeoffs between immunogenicity and safety.Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when compared to inactivated vaccines.In contrast, the inability of inactivated vaccines to replicate enhances safety at the expense of immu... |
22,080,671 | Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for clearly identifying each of these cell types.Here, using Myh11-CreERT2 ROSA floxed STOP eYFP Apoe−/− mice to perform... |
56,893,404 | Background Macrosomia is associated with considerable neonatal and maternal morbidity.Factors that predict macrosomia are poorly understood.The increased rate of macrosomia in the offspring of pregnant women with diabetes and in congenital hyperinsulinaemia is mediated by increased foetal insulin secretion.We assessed... |
12,428,497 | BACKGROUND Adoption of new and underutilized vaccines by national immunization programs is an essential step towards reducing child mortality.Policy decisions to adopt new vaccines in high mortality countries often lag behind decisions in high-income countries.Using the case of Haemophilus influenzae type b (Hib) vacci... |
9,669,099 | Binding within or nearby target genes involved in cell proliferation and survival enables the p53 tumor suppressor gene to regulate their transcription and cell-cycle progression.Using genome-wide chromatin-binding profiles, we describe binding of p53 also to regions located distantly from any known p53 target gene.Int... |
15,663,829 | BACKGROUND Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) levels in blood and risk of type 2 diabetes (T2D), but the prospective association of BNP with T2D is uncertain, and it is unclear whether the association is confounded.
METHODS AND FINDINGS We an... |
23,460,562 | It is unclear how the immune response in early life becomes appropriately stimulated to provide protection while also avoiding excessive activation as a result of diverse new antigens.T cells are integral to adaptive immunity; mouse studies indicate that tissue localization of T cell subsets is important for both prote... |
3,944,632 | CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone.
OBJECTIVE To determine if WBRT combined with SRS results in improvements in surv... |
5,912,283 | CONTEXT Insomnia is a common condition in older adults and is associated with a number of adverse medical, social, and psychological consequences.Previous research has suggested beneficial outcomes of both psychological and pharmacological treatments, but blinded placebo-controlled trials comparing the effects of these... |
31,554,917 | Circadian rhythm sleep disorders are characterized by complaints of insomnia and excessive sleepiness that are primarily due to alterations in the internal circadian timing system or a misalignment between the timing of sleep and the 24-h social and physical environment.In addition to physiological and environmental fa... |
1,982,286 | The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL).Here we used reverse engineering of global transcriptional networks to decipher the oncogenic regulatory circuit controlled by TLX1 and TLX3.This systems biology analysis defined T cell le... |
16,390,264 | OBJECTIVES To determine the extent to which type of hospital admission (emergency compared with elective) and surgical procedure varied by socioeconomic circumstances, age, sex, and year of admission for colorectal, breast, and lung cancer.
DESIGN Repeated cross sectional study with data from individual patients, 1 ... |
5,099,266 | Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1.Once bacterial molecules are sensed within the macrophage, the inflammasome is assembled, mediating the activation of caspase-1.Caspase-11 mediates caspase-1 activatio... |
26,973,393 | All patients with metastatic lung, colorectal, pancreatic or head and neck cancers who initially benefit from epidermal growth factor receptor (EGFR)-targeted therapies eventually develop resistance.An increasing understanding of the number and complexity of resistance mechanisms highlights the Herculean challenge of k... |
23,078,022 | Nuclear factor-κB (NF-κB) is constitutively activated in diverse human malignancies by mechanisms that are not understood.The MUC1 oncoprotein is aberrantly overexpressed by most human carcinomas and, similarly to NF-κB, blocks apoptosis and induces transformation.This study demonstrates that overexpression of MUC1 in ... |
End of preview.
No dataset card yet
- Downloads last month
- 1